[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: dehydration
Target surface form: dehydration
Context:
How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent <t>dehydration</t>) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects.

Candidate senses:
1. sense_key=dehydration%1:26:00:: | definition=dryness resulting from the removal of water | synonyms=desiccation
2. sense_key=dehydration%1:26:01:: | definition=depletion of bodily fluids
3. sense_key=dehydration%1:22:00:: | definition=the process of extracting moisture | synonyms=desiccation, drying up, evaporation

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "dehydration" in the given context, let's analyze the provided information step by step.

1. **Context Analysis**: The passage discusses the usage and administration guidelines for a drug named Alimta, which is used in chemotherapy. It mentions various precautions and supplementary treatments to be given alongside Alimta, such as corticosteroids, folic acid, vitamin B12, anti-emetic medicine, and fluids. The specific mention related to "dehydration" is in the context of administering fluids to prevent it when Alimta is given with cisplatin.

2. **Understanding the Term "Dehydration"**: The term "dehydration" generally refers to the loss of water. In a medical context, it often relates to the loss of bodily fluids.

3. **Examining the Candidate Senses**:
   - **1. dryness resulting from the removal of water**: This definition is more related to the desiccation of objects or materials rather than a medical condition related to bodily fluids.
   - **2. depletion of bodily fluids**: This directly relates to a medical condition where the body loses more fluids than it takes in, which can be a side effect of certain medical treatments.
   - **3. the process of extracting moisture**: While related to dehydration, this definition is more about a process and is synonymous with desiccation and drying up, which doesn't directly fit the context of preventing a medical condition as a side effect.

4. **Relating the Context to the Candidate Senses**: The context is about preventing a medical condition (dehydration) as a side effect of a chemotherapy treatment by administering fluids. Thus, the most relevant definition is related to the depletion of bodily fluids, which is a direct concern in the medical treatment context.

5. **Choosing the Best Indexed Sense**: Based on the context and the definitions provided, the best sense for "dehydration" is the one that refers to the "depletion of bodily fluids."

Given the definitions:
- Sense 1 refers to dryness resulting from water removal, not directly related to bodily fluids.
- Sense 2 is about the depletion of bodily fluids, directly relevant to the medical context provided.
- Sense 3 talks about the process of extracting moisture, which is not the focus in the given context.

Therefore, the correct sense is the one that corresponds to the depletion of bodily fluids.

{"sense_index": 2}


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: give
Target surface form: given
Context:
How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be <t>given</t> before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects.

Candidate senses:
1. sense_key=give%2:40:03:: | definition=cause to have, in the abstract sense or physical sense | examples=She gave him a black eye; The draft gave me a cold
2. sense_key=give%2:40:05:: | definition=be the cause or source of | synonyms=yield, afford | examples=He gave me a lot of trouble; Our meeting afforded much interesting information
3. sense_key=give%2:40:00:: | definition=transfer possession of something concrete or abstract to somebody | examples=I gave her my money; can you give me lessons?
4. sense_key=give%2:40:07:: | definition=convey or reveal information | examples=Give one's name
5. sense_key=give%2:32:01:: | definition=convey, as of a compliment, regards, attention, etc.; bestow | synonyms=pay | examples=Don't pay him any mind; give the orders
6. sense_key=give%2:36:02:: | definition=organize or be responsible for | synonyms=hold, throw, have, make | examples=hold a reception; have, throw, or make a party
7. sense_key=give%2:32:00:: | definition=convey or communicate; of a smile, a look, a physical gesture | synonyms=throw | examples=Throw a glance; She gave me a dirty look
8. sense_key=give%2:40:01:: | definition=give as a present; make a gift of | synonyms=gift, present | examples=What will you give her for her birthday?
9. sense_key=give%2:36:03:: | definition=cause to happen or be responsible for | synonyms=yield | examples=His two singles gave the team the victory
10. sense_key=give%2:31:02:: | definition=dedicate | synonyms=pay, devote | examples=give thought to; give priority to
11. sense_key=give%2:36:00:: | definition=give or supply | synonyms=render, yield, return, generate | examples=The cow brings in 5 liters of milk; This year's crop yielded 1,000 bushels of corn
12. sense_key=give%2:40:09:: | definition=transmit (knowledge or skills) | synonyms=impart, leave, pass on | examples=give a secret to the Russians; leave your name and address here
13. sense_key=give%2:36:01:: | definition=bring about | synonyms=establish | examples=The trompe l'oeil-illusion establishes depth
14. sense_key=give%2:40:02:: | definition=leave with; give temporarily | examples=Can I give you my keys while I go in the pool?; Can I give you the children for the weekend?
15. sense_key=give%2:41:00:: | definition=emit or utter | examples=Give a gulp; give a yelp
16. sense_key=give%2:40:10:: | definition=endure the loss of | synonyms=sacrifice | examples=He gave his life for his children; I gave two sons to the war
17. sense_key=give%2:40:06:: | definition=place into the hands or custody of | synonyms=pass, hand, reach, pass on, turn over | examples=hand me the spoon, please; Turn the files over to me, please
18. sense_key=give%2:32:03:: | definition=give entirely to a specific person, activity, or cause | synonyms=dedicate, consecrate, commit, devote | examples=She committed herself to the work of God; give one's talents to a good cause
19. sense_key=give%2:40:13:: | definition=give (as medicine) | examples=I gave him the drug
20. sense_key=give%2:40:14:: | definition=give or convey physically | synonyms=apply | examples=She gave him First Aid; I gave him a punch in the nose
21. sense_key=give%2:32:02:: | definition=bestow | synonyms=render | examples=give homage; render thanks
22. sense_key=give%2:40:11:: | definition=bestow, especially officially | synonyms=grant | examples=grant a degree; give a divorce
23. sense_key=give%2:38:00:: | definition=move in order to make room for someone for something | synonyms=move over, give way, ease up, yield | examples=The park gave way to a supermarket; `Move over,' he told the crowd
24. sense_key=give%2:34:00:: | definition=give food to | synonyms=feed | examples=Feed the starving children in India; don't give the child this tough meat
25. sense_key=give%2:40:08:: | definition=contribute to some cause | synonyms=contribute, chip in, kick in | examples=I gave at the office
26. sense_key=give%2:38:13:: | definition=break down, literally or metaphorically | synonyms=collapse, fall in, cave in, give way, break, founder | examples=The wall collapsed; The business collapsed
27. sense_key=give%2:31:00:: | definition=estimate the duration or outcome of something | examples=He gave the patient three months to live; I gave him a very good chance at success
28. sense_key=give%2:41:10:: | definition=execute and deliver | examples=Give bond
29. sense_key=give%2:40:12:: | definition=deliver in exchange or recompense | examples=I'll give you three books for four CDs
30. sense_key=give%2:40:15:: | definition=afford access to | synonyms=afford, open | examples=the door opens to the patio; The French doors give onto a terrace
31. sense_key=give%2:36:13:: | definition=present to view | examples=He gave the sign to start
32. sense_key=give%2:36:12:: | definition=perform for an audience | examples=Pollini is giving another concert in New York
33. sense_key=give%2:35:00:: | definition=be flexible under stress of physical force | synonyms=yield | examples=This material doesn't give
34. sense_key=give%2:34:10:: | definition=propose | examples=He gave the first of many toasts at the birthday party
35. sense_key=give%2:32:11:: | definition=accord by verdict | examples=give a decision for the plaintiff
36. sense_key=give%2:32:08:: | definition=manifest or show | examples=This student gives promise of real creativity; The office gave evidence of tampering
37. sense_key=give%2:32:15:: | definition=offer in good faith | examples=He gave her his word
38. sense_key=give%2:32:14:: | definition=submit for consideration, judgment, or use | examples=give one's opinion; give an excuse
39. sense_key=give%2:32:09:: | definition=guide or direct, as by behavior of persuasion | examples=You gave me to think that you agreed with me
40. sense_key=give%2:32:07:: | definition=allow to have or take | examples=I give you two minutes to respond
41. sense_key=give%2:32:10:: | definition=inflict as a punishment | examples=She gave the boy a good spanking; The judge gave me 10 years
42. sense_key=give%2:30:13:: | definition=occur | examples=what gives?
43. sense_key=give%2:29:11:: | definition=consent to engage in sexual intercourse with a man | examples=She gave herself to many men
44. sense_key=give%2:29:10:: | definition=proffer (a body part) | examples=She gave her hand to her little sister

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "given" in the provided context, let's analyze the given information and the candidate senses.

The context is about the usage and administration of a drug called Alimta, which is used in anticancer chemotherapy. The text discusses how Alimta should be administered, its recommended dose, and the necessary precautions and supplementary treatments.

The target sentence is: "When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be <t>given</t> before or after the cisplatin dose."

Here, "given" is used in the context of administering drugs or medical treatments. The relevant candidate senses related to this context are:

- sense_key=give%2:40:19:: | definition=give (as medicine) | examples=I gave him the drug
- Other senses related to "give" in various contexts, but not directly related to administering medicine.

The usage of "given" in the context clearly refers to the administration of medical substances (Alimta, cisplatin, anti-emetic medicine, and fluids). The most relevant definition is "give (as medicine)" which directly corresponds to the administration of drugs.

The sense index corresponding to "give (as medicine)" is 19.

Therefore, the best indexed sense for the target word "given" in the context is: {"sense_index": 19}.

finish_reason: stop

role: assistant

currency: USD

source: unavailable


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: before
Target surface form: before
Context:
How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given <t>before</t> or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects.

Candidate senses:
1. sense_key=before%4:02:03:: | definition=earlier in time; previously | synonyms=earlier | examples=I had known her before; as I said before
2. sense_key=before%4:02:01:: | definition=at or in the front | synonyms=ahead, in front | examples=I see the lights of a town ahead; the road ahead is foggy

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the correct sense of "before" in the given context, let's analyze the sentence and the provided candidate senses.

The sentence is: "...an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose."

Here, "before" is used in relation to the timing of administering an anti-emetic medicine and fluids relative to the cisplatin dose. It indicates that these should be given earlier in time than the cisplatin dose.

Let's examine the candidate senses:

1. The first sense is defined as "earlier in time; previously" with synonyms like "earlier" and examples such as "I had known her before; as I said before." This sense aligns with the usage in the given context, where "before" indicates that something should be done earlier in time relative to the cisplatin dose.

2. The second sense is defined as "at or in the front" with synonyms like "ahead" and "in front" and examples such as "I see the lights of a town ahead; the road ahead is foggy." This sense refers to a spatial or positional relationship rather than a temporal one, which doesn't fit the context of timing the administration of medicines.

Given the context and the definitions, the usage of "before" clearly refers to something happening earlier in time relative to another event (the administration of the cisplatin dose). Thus, it matches the first sense provided.

Therefore, the best indexed sense for "before" in this context is the first one.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: after
Target surface form: after
Context:
How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or <t>after</t> the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects.

Candidate senses:
1. sense_key=after%4:02:01:: | definition=happening at a time subsequent to a reference time | synonyms=subsequently, later, afterwards, afterward, later on | examples=he apologized subsequently; he's going to the store but he'll be back here later
2. sense_key=after%4:02:00:: | definition=behind or in the rear | examples=and Jill came tumbling after

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the correct sense of the word "after" in the given context, let's analyze the sentence and the provided candidate senses.

The sentence in question is: "...an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose."

Here, "after" is used to indicate a time subsequent to the administration of the cisplatin dose. The context is about the timing of giving certain medicines or fluids relative to the cisplatin dose.

Let's examine the candidate senses:

1. The first sense is defined as "happening at a time subsequent to a reference time" with synonyms like "subsequently, later, afterwards, afterward, later on." The example given is "he apologized subsequently; he's going to the store but he'll be back here later." This sense fits the context because "after" is used to indicate that something happens at a time subsequent to the cisplatin dose.

2. The second sense is defined as "behind or in the rear" with an example "and Jill came tumbling after." This sense does not fit the context because "after" is not used to indicate a physical position or order but rather a temporal relationship.

Given the context and the definitions, the use of "after" in the sentence aligns with the first sense, which is about something happening at a time subsequent to a reference time.

Therefore, the best indexed sense for "after" in the given context is the first one.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: dose
Target surface form: dose
Context:
How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin <t>dose</t>. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects.

Candidate senses:
1. sense_key=dose%1:06:00:: | definition=a measured portion of medicine taken at any one time | synonyms=dosage
2. sense_key=dose%1:23:00:: | definition=the quantity of an active agent (substance or radiation) taken in or absorbed at any one time | synonyms=dosage
3. sense_key=dose%1:26:00:: | definition=a communicable infection transmitted by sexual intercourse or genital contact | synonyms=venereal disease, VD, venereal infection, social disease, Cupid's itch, Cupid's disease
4. sense_key=dose%1:06:01:: | definition=street name for lysergic acid diethylamide | synonyms=acid, back breaker, battery-acid, dot, Elvis, loony toons

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "dose" in the given context, let's analyze the provided information step by step.

1. **Context Analysis**: The passage discusses the usage of a drug named Alimta, including its recommended dosage, administration method, and how to manage its side effects. It also mentions another drug, cisplatin, and the administration of various supplements and anti-emetic medicines.

2. **Target Word Context**: The target word "dose" appears in the phrase "before or after the cisplatin dose." This indicates that "dose" refers to a quantity of a drug (cisplatin, in this case) administered at one time.

3. **Candidate Senses Analysis**:
   - **1. sense_key=dose%1:06:00::**: This sense defines "dose" as "a measured portion of medicine taken at any one time" with a synonym "dosage." This aligns with the context where "dose" refers to the quantity of cisplatin given.
   - **2. sense_key=dose%1:23:00::**: This defines "dose" as "the quantity of an active agent (substance or radiation) taken in or absorbed at any one time," also with a synonym "dosage." While this is somewhat relevant, the context specifically talks about medicine, making the first sense more directly applicable.
   - **3. sense_key=dose%1:26:00::**: This sense is unrelated to the context as it refers to a venereal disease, which is not relevant to the discussion about drug administration.
   - **4. sense_key=dose%1:06:01::**: This refers to "lysergic acid diethylamide" (LSD), which is not relevant to the context.

4. **Choosing the Best Indexed Sense**: Given the context is about the administration of a specific quantity of a drug (cisplatin), the most relevant definition is "a measured portion of medicine taken at any one time." This matches the first candidate sense.

5. **Response**: The first sense is indexed as "1." Therefore, the best response is {"sense_index": 1}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: treatment
Target surface form: Treatment
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. <t>Treatment</t> should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=treatment%1:04:00:: | definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) | synonyms=intervention
2. sense_key=treatment%1:04:01:: | definition=the management of someone or something | synonyms=handling | examples=the handling of prisoners; the treatment of water sewage
3. sense_key=treatment%1:07:00:: | definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture
4. sense_key=treatment%1:10:00:: | definition=an extended communication (often interactive) dealing with some particular topic | synonyms=discussion, discourse | examples=the book contains an excellent discussion of modal logic; his treatment of the race question is badly biased

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "Treatment" in the given context, let's analyze the provided information step by step.

1. **Context Analysis**: The passage discusses the administration of a drug named Alimta, including its recommended dosage, method of administration, and measures to reduce side effects. It also mentions conditions under which the treatment should be delayed, discontinued, or the dose reduced.

2. **Understanding the Target Word**: The word "Treatment" is used in the context of administering Alimta to patients. The relevant sentence is: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects."

3. **Examining Candidate Senses**:
   - **1. care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)**: This sense is related to medical care or intervention, which aligns with the context of administering a drug to patients.
   - **2. the management of someone or something**: While this is a broad definition that could encompass medical management, it's more general and not limited to medical contexts.
   - **3. a manner of dealing with something artistically**: This sense is related to artistic or creative handling of a subject, which doesn't fit the medical context provided.
   - **4. an extended communication (often interactive) dealing with some particular topic**: This refers to a discussion or discourse on a particular subject, not relevant to the administration of a medical treatment.

4. **Choosing the Best Indexed Sense**:
   - The context is clearly medical, focusing on the administration of a drug and its management.
   - Sense 1 directly relates to medical procedures or applications intended to relieve illness or injury, fitting the context of administering Alimta.
   - Sense 2, while potentially applicable in a broad sense, is less specific to the medical context than Sense 1.

Given the context and the definitions provided, the most appropriate sense for "Treatment" is Sense 1, as it directly pertains to medical care and intervention.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: delay
Target surface form: delayed
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be <t>delayed</t> or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=delay%2:30:00:: | definition=cause to be slowed down or delayed | synonyms=detain, hold up | examples=Traffic was delayed by the bad weather; she delayed the work that she didn't want to perform
2. sense_key=delay%2:42:00:: | definition=act later than planned, scheduled, or required | examples=Don't delay your application to graduate school or else it won't be considered
3. sense_key=delay%2:30:01:: | definition=stop or halt | synonyms=stay, detain | examples=Please stay the bloodshed!
4. sense_key=delay%2:30:05:: | definition=slow the growth or development of | synonyms=check, retard | examples=The brain damage will retard the child's language development

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the word "delayed" in the given context, let's analyze the context and the provided candidate senses.

The context is about the administration of a drug called Alimta, used in anticancer chemotherapy, and the conditions under which its treatment should be adjusted, specifically when it should be "delayed or discontinued, or the dose reduced." The relevant sentence is: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects."

Let's examine the candidate senses:

1. The first sense is defined as "cause to be slowed down or delayed" with synonyms "detain, hold up." The examples given are "Traffic was delayed by the bad weather; she delayed the work that she didn't want to perform." This sense implies an external cause that results in a delay.

2. The second sense is "act later than planned, scheduled, or required." An example is "Don't delay your application to graduate school or else it won't be considered." This involves a decision or action to postpone something.

3. The third sense is "stop or halt" with synonyms "stay, detain." The example is "Please stay the bloodshed!" This implies a more immediate or decisive action to halt something.

4. The fourth sense is "slow the growth or development of" with synonyms "check, retard." An example is "The brain damage will retard the child's language development." This involves an impact on the rate of development or growth.

In the given context, "Treatment should be delayed" implies that the administration of the treatment is to be postponed or put off until a later time, likely due to certain conditions (abnormal blood counts or other side effects). This aligns with the idea of acting later than planned or scheduled, which is related to the second sense.

Therefore, the best indexed sense for "delayed" in this context is the second sense, which corresponds to sense_index = 2.

{"sense_index": 2}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: discontinue
Target surface form: discontinued
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or <t>discontinued</t>, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=discontinue%2:42:00:: | definition=put an end to a state or an activity | synonyms=stop, cease, give up, quit, lay off | examples=Quit teasing your little brother
2. sense_key=discontinue%2:42:01:: | definition=come to or be at an end | examples=the support from our sponsoring agency will discontinue after March 31
3. sense_key=discontinue%2:30:00:: | definition=prevent completion | synonyms=break, break off, stop | examples=stop the project; break off the negotiations

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the word "discontinued" in the given context, let's analyze the context and the provided candidate senses.

The context is about the administration of a medicine called Alimta, including its dosage, potential side effects, and conditions under which its treatment should be adjusted. The sentence containing "discontinued" states that treatment should be delayed or discontinued, or the dose reduced, in patients with certain health issues.

Let's examine the candidate senses:

1. The first sense is defined as "put an end to a state or an activity" with synonyms like "stop, cease, give up, quit, lay off." The example given is "Quit teasing your little brother." This sense implies an action taken to end something. In the context, "discontinued" refers to the action taken regarding the treatment with Alimta, implying that the treatment is being stopped due to certain conditions.

2. The second sense is "come to or be at an end," with an example related to support from a sponsoring agency ending after a specific date. This sense implies something reaching its end naturally or as a result of a condition being met.

3. The third sense is "prevent completion" with synonyms "break, break off, stop," and examples like "stop the project; break off the negotiations." This implies an action that interrupts or halts something before it is completed.

In the given context, "discontinued" refers to the decision to stop the treatment with Alimta under certain conditions (e.g., abnormal blood counts or certain side effects). This action is taken by a medical professional, indicating an intentional decision to end the treatment, rather than the treatment naturally coming to an end.

The first sense ("put an end to a state or an activity") fits this context best because it involves an intentional action (by the doctor) to stop the treatment. The synonyms provided ("stop, cease, give up, quit, lay off") all convey the idea of intentionally ending an activity or state, which aligns with the decision to discontinue Alimta treatment based on patient conditions.

Therefore, the best indexed sense for "discontinued" in this context is the first one.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: dose
Target surface form: dose
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the <t>dose</t> reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=dose%1:06:00:: | definition=a measured portion of medicine taken at any one time | synonyms=dosage
2. sense_key=dose%1:23:00:: | definition=the quantity of an active agent (substance or radiation) taken in or absorbed at any one time | synonyms=dosage
3. sense_key=dose%1:26:00:: | definition=a communicable infection transmitted by sexual intercourse or genital contact | synonyms=venereal disease, VD, venereal infection, social disease, Cupid's itch, Cupid's disease
4. sense_key=dose%1:06:01:: | definition=street name for lysergic acid diethylamide | synonyms=acid, back breaker, battery-acid, dot, Elvis, loony toons

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "dose" in the given context, let's analyze the provided information step by step.

1. **Context Analysis**: The passage discusses the administration of a drug named Alimta, which is used in anticancer chemotherapy. It provides details about the recommended quantity of Alimta to be administered, the frequency of administration, and how the treatment should be adjusted based on the patient's condition.

2. **Understanding the Target Word**: The target word is "dose," and it appears in the context of administering Alimta and adjusting the quantity based on patient conditions.

3. **Examining Candidate Senses**:
   - **1. sense_key=dose%1:06:00::**: This sense defines "dose" as a measured portion of medicine taken at any one time. The synonym provided is "dosage."
   - **2. sense_key=dose%1:23:00::**: This sense defines "dose" as the quantity of an active agent (substance or radiation) taken in or absorbed at any one time. Again, "dosage" is a synonym.
   - **3. sense_key=dose%1:26:00::**: This defines "dose" as a communicable infection transmitted by sexual intercourse or genital contact, with synonyms like "venereal disease" and others.
   - **4. sense_key=dose%1:06:01::**: This sense refers to "dose" as a street name for lysergic acid diethylamide (LSD), with various slang terms as synonyms.

4. **Choosing the Best Indexed Sense**:
   - The context is medical, focusing on the administration of a chemotherapy drug.
   - Both senses 1 and 2 relate to the quantity of a substance (medicine or an active agent) administered.
   - Sense 1 specifically mentions "medicine," which aligns closely with the context of administering Alimta.
   - Sense 2 is broader, encompassing not just medicine but any active agent, including radiation.

Given the context is about administering a specific quantity of a chemotherapy drug (Alimta) and adjusting it based on patient conditions, both senses 1 and 2 seem relevant. However, sense 2 is broader and encompasses the concept of an "active agent," which could include drugs like Alimta.

Upon closer inspection, the distinction between senses 1 and 2 is subtle, with both being relevant. However, the context emphasizes the quantity of the drug administered ("500 mg per square metre of body surface area"), which aligns with the definition of sense 2 as "the quantity of an active agent... taken in or absorbed at any one time." The use of "dosage" as a synonym for both senses also indicates a close relationship between the two.

Since the context is about the quantity of a drug (an active agent) and not just any medicine, and given that "dosage" is a synonym for both relevant senses, the most appropriate choice leans towards the broader definition that encompasses the concept of an active agent.

Therefore, the best indexed sense for "dose" in this context is **2**.

The final answer is: {"sense_index": 2}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: reduce
Target surface form: reduced
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose <t>reduced</t>, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=reduce%2:30:00:: | definition=cut down on; make a reduction in | synonyms=cut down, cut back, trim, trim down, trim back, cut | examples=reduce your daily fat intake; The employer wants to cut back health benefits
2. sense_key=reduce%2:30:06:: | definition=make less complex | examples=reduce a problem to a single question
3. sense_key=reduce%2:41:00:: | definition=bring to humbler or weaker state or condition | examples=He reduced the population to slavery
4. sense_key=reduce%2:40:04:: | definition=simplify the form of a mathematical equation of expression by substituting one term for another
5. sense_key=reduce%2:37:00:: | definition=lower in grade or rank or force somebody into an undignified situation | examples=She reduced her niece to a servant
6. sense_key=reduce%2:30:11:: | definition=be the essential element | synonyms=come down, boil down | examples=The proposal boils down to a compromise
7. sense_key=reduce%2:30:05:: | definition=reduce in size; reduce physically | synonyms=shrink | examples=Hot water will shrink the sweater; Can you shrink this image?
8. sense_key=reduce%2:40:00:: | definition=lessen and make more modest | examples=reduce one's standard of living
9. sense_key=reduce%2:30:04:: | definition=make smaller | synonyms=scale down | examples=reduce an image
10. sense_key=reduce%2:30:03:: | definition=to remove oxygen from a compound, or cause to react with hydrogen or form a hydride, or to undergo an increase in the number of electrons | synonyms=deoxidize, deoxidise
11. sense_key=reduce%2:30:01:: | definition=narrow or limit | synonyms=tighten | examples=reduce the influx of foreigners
12. sense_key=reduce%2:41:03:: | definition=put down by force or intimidation | synonyms=repress, quash, keep down, subdue, subjugate | examples=The government quashes any attempt of an uprising; China keeps down her dissidents very efficiently
13. sense_key=reduce%2:35:00:: | definition=undergo meiosis | examples=The cells reduce
14. sense_key=reduce%2:35:01:: | definition=reposition (a broken bone after surgery) back to its normal site
15. sense_key=reduce%2:30:12:: | definition=destress and thus weaken a sound when pronouncing it
16. sense_key=reduce%2:30:08:: | definition=reduce in scope while retaining essential elements | synonyms=abridge, foreshorten, abbreviate, shorten, cut, contract | examples=The manuscript must be shortened
17. sense_key=reduce%2:30:10:: | definition=be cooked until very little liquid is left | synonyms=boil down, decoct, concentrate | examples=The sauce should reduce to one cup
18. sense_key=reduce%2:30:02:: | definition=cook until very little liquid is left | synonyms=boil down, concentrate | examples=The cook reduced the sauce by boiling it for a long time
19. sense_key=reduce%2:30:09:: | definition=lessen the strength or flavor of a solution or mixture | synonyms=dilute, thin, thin out, cut | examples=cut bourbon
20. sense_key=reduce%2:29:00:: | definition=take off weight | synonyms=melt off, lose weight, slim, slenderize, thin, slim down

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "reduced" in the given context, let's analyze the sentence and the provided candidate senses.

The sentence is: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects."

The context is about adjusting the dose of a medication (Alimta) based on the patient's condition. The word "reduced" here refers to decreasing the amount or quantity of the dose.

Let's examine the candidate senses:

1. "cut down on; make a reduction in" - This sense fits the context as it involves making a reduction, which aligns with decreasing the dose.
2. Other senses relate to various meanings such as simplifying, bringing to a weaker state, lowering in grade, etc., which don't directly fit the context of adjusting a medication dose.

The synonyms provided for sense 1 are "cut down, cut back, trim, trim down, trim back, cut," which all relate to the idea of reducing something, in this case, the dose of a medication.

Given the context and the examples, the most appropriate sense is the one that involves making a reduction in something, which is sense 1.

Therefore, the best indexed sense for "reduced" in the given context is: {"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in <t>patients</t> whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "patients" in the given context, let's analyze the provided information.

The context revolves around medical treatment, specifically the administration of a drug called Alimta, its dosage, and the management of its side effects. The term "patients" is used in relation to individuals undergoing this treatment.

The candidate senses provided are:
1. A person who requires medical care.
2. The semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause.

Let's examine the context and the examples given for the candidate senses.

The sentence context clearly indicates that "patients" refers to individuals receiving medical treatment, specifically Alimta. The examples given for the first sense ("the number of emergency patients has grown rapidly") align with this usage, as it refers to individuals requiring medical care.

The second sense refers to a semantic role in a clause, which doesn't directly relate to the context of individuals receiving medical treatment. It's more about the grammatical or semantic function of a noun in a sentence rather than the noun's meaning.

Given the context and the examples, the term "patients" is used to denote individuals who are receiving or are candidates for medical treatment with Alimta. This aligns with the first sense: "a person who requires medical care."

Therefore, the best indexed sense for "patients" in the given context is the first one.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: blood_count
Target surface form: blood counts
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose <t>blood counts</t> are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=blood_count%1:23:00:: | definition=the number of red and white corpuscles in a blood sample
2. sense_key=blood_count%1:04:00:: | definition=the act of estimating the number of red and white corpuscles in a blood sample

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for "blood counts" in the given context, let's analyze the information provided.

The context discusses the administration of Alimta, a chemotherapy drug, and the conditions under which its treatment should be adjusted or stopped. It mentions that "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects."

The two candidate senses for "blood count" are:
1. The number of red and white corpuscles in a blood sample.
2. The act of estimating the number of red and white corpuscles in a blood sample.

The sentence implies that the "blood counts" are being measured or evaluated for being "abnormal." This suggests that "blood counts" refers to the result of a measurement or count rather than the act of counting itself.

Using the context and the definitions provided:
- The first sense refers to "the number of red and white corpuscles in a blood sample," which aligns with the idea of a result or a value (the count) being abnormal.
- The second sense refers to "the act of estimating the number of red and white corpuscles in a blood sample," which is the process of counting.

Given that the context discusses the outcome (being abnormal) rather than the process, the most appropriate sense is the one referring to the result or the count itself.

Therefore, the best indexed sense for "blood counts" in this context is the first one, which corresponds to the definition related to the number or count.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: abnormal
Target surface form: abnormal
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are <t>abnormal</t> or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=abnormal%3:00:00:: | definition=not normal; not typical or usual or regular or conforming to a norm | synonyms=unnatural | examples=abnormal powers of concentration; abnormal amounts of rain
2. sense_key=abnormal%3:00:03:: | definition=departing from the normal in e.g. intelligence and development | examples=they were heartbroken when they learned their child was abnormal; an abnormal personality
3. sense_key=abnormal%5:00:00:immoderate:00 | definition=much greater than the normal | examples=abnormal profits; abnormal ambition

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the word "abnormal" in the given context, let's analyze the context and the provided candidate senses.

The context is a medical description of the usage and administration guidelines for a drug named Alimta. The specific sentence where "abnormal" is used is: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects."

1. The first sense defines "abnormal" as not normal; not typical or usual or regular or conforming to a norm, with examples like "abnormal powers of concentration" and "abnormal amounts of rain." The synonym given is "unnatural." This sense is quite general and could apply to various contexts where something deviates from the norm.

2. The second sense focuses on departing from the normal in aspects such as intelligence and development, with examples like "they were heartbroken when they learned their child was abnormal" and "an abnormal personality." This sense leans more towards developmental or psychological aspects.

3. The third sense defines "abnormal" as much greater than the normal, with examples like "abnormal profits" and "abnormal ambition." This sense implies an excess or a significant deviation in a quantitative sense.

Given the context, "abnormal" is used to describe "blood counts." Blood counts are a medical measurement, and being "abnormal" here means that the counts are not within the normal or expected range, which could imply either higher or lower than normal counts. The usage here is more about a deviation from a standard or norm rather than implying something is unnatural, excessively high, or related to developmental issues.

The most fitting definition is the first one, as it generally covers the notion of something not being within the normal range without specifying the direction of the deviation (higher or lower). "Abnormal blood counts" can mean counts that are either significantly higher or lower than the normal range, and this usage aligns with the first sense.

Therefore, the best indexed sense for "abnormal" in this context is the first one.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: have
Target surface form: have
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who <t>have</t> certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=have%2:40:00:: | definition=have or possess, either in a concrete or an abstract sense | synonyms=have got, hold | examples=She has $1,000 in the bank; He has got two beautiful daughters
2. sense_key=have%2:42:00:: | definition=have as a feature | synonyms=feature | examples=This restaurant features the most famous chefs in France
3. sense_key=have%2:39:06:: | definition=go through (mental or physical states or experiences) | synonyms=experience, receive, get | examples=get an idea; experience vertigo
4. sense_key=have%2:40:04:: | definition=have ownership or possession of | synonyms=own, possess | examples=He owns three houses in Florida; How many cars does she have?
5. sense_key=have%2:30:00:: | definition=cause to move; cause to be in a certain position or condition | synonyms=get, let | examples=He got his squad on the ball; This let me in for a big surprise
6. sense_key=have%2:34:00:: | definition=serve oneself to, or consume regularly | synonyms=consume, ingest, take in, take | examples=Have another bowl of chicken soup!; I don't take sugar in my coffee
7. sense_key=have%2:41:00:: | definition=have a personal or business relationship with someone | examples=have a postdoc; have an assistant
8. sense_key=have%2:36:00:: | definition=organize or be responsible for | synonyms=hold, throw, make, give | examples=hold a reception; have, throw, or make a party
9. sense_key=have%2:40:01:: | definition=have left | examples=I have two years left; I don't have any money left
10. sense_key=have%2:42:12:: | definition=be confronted with | examples=What do we have here?; Now we have a fine mess
11. sense_key=have%2:30:01:: | definition=undergo | synonyms=experience | examples=The stocks had a fast run-up
12. sense_key=have%2:29:02:: | definition=suffer from; be ill with | examples=She has arthritis
13. sense_key=have%2:32:00:: | definition=cause to do; cause to act in a specified manner | synonyms=induce, stimulate, cause, get, make | examples=The ads induced me to buy a VCR; My children finally got me to buy a computer
14. sense_key=have%2:40:05:: | definition=receive willingly something given or offered | synonyms=accept, take | examples=The only girl who would have him was the miller's daughter; I won't have this dog in my house!
15. sense_key=have%2:40:03:: | definition=get something; come into possession of | synonyms=receive | examples=receive payment; receive a gift
16. sense_key=have%2:29:05:: | definition=undergo (as of injuries and illnesses) | synonyms=suffer, sustain, get | examples=She suffered a fracture in the accident; He had an insulin shock after eating three candy bars
17. sense_key=have%2:40:02:: | definition=achieve a point or goal | synonyms=get, make | examples=Nicklaus had a 70; The Brazilian team got 4 goals
18. sense_key=have%2:29:00:: | definition=cause to be born | synonyms=give birth, deliver, bear, birth | examples=My wife had twins yesterday!
19. sense_key=have%2:35:00:: | definition=have sex with; archaic use | synonyms=take | examples=He had taken this woman when she was most vulnerable

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "have" in the given context, let's analyze the sentence and the provided candidate senses.

The sentence is: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects."

Here, "have" is used in the context of patients experiencing or suffering from certain side effects. The relevant candidate senses that could fit this context are those related to experiencing, suffering, or undergoing something.

Let's examine the relevant senses:
- Sense 3: "go through (mental or physical states or experiences)" with synonyms "experience, receive, get" and examples like "get an idea; experience vertigo." This sense is plausible because it involves experiencing or going through certain states or conditions.
- Sense 12: "suffer from; be ill with" with the example "She has arthritis." This directly relates to having or suffering from a condition or illness.
- Sense 16: "undergo (as of injuries and illnesses)" with synonyms "suffer, sustain, get" and examples like "She suffered a fracture in the accident; He had an insulin shock after eating three candy bars." This sense is also relevant as it involves undergoing or suffering from certain health issues.

Given the context, "have certain other side effects" implies that the patients are experiencing or suffering from these side effects. The most fitting sense here is related to experiencing or suffering from certain conditions.

Sense 12 directly corresponds to suffering from or being ill with a condition, which aligns with the context of having side effects.

Therefore, the best indexed sense for "have" in this context is Sense 12.

{"sense_index": 12}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: certain
Target surface form: certain
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have <t>certain</t> other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=certain%5:00:00:definite:00 | definition=definite but not specified or identified | examples=set aside a certain sum each week; to a certain degree
2. sense_key=certain%3:00:02:: | definition=having or feeling no doubt or uncertainty; confident and assured | synonyms=sure | examples=felt certain of success; was sure (or certain) she had seen it
3. sense_key=certain%3:00:01:: | definition=established beyond doubt or question; definitely known | examples=what is certain is that every effect must have a cause; it is certain that they were on the bus
4. sense_key=certain%3:00:03:: | definition=certain to occur; destined or inevitable; ; ; - Benjamin Franklin | synonyms=sure | examples=he was certain to fail; his fate is certain
5. sense_key=certain%3:00:05:: | definition=established irrevocably | synonyms=sealed | examples=his fate is sealed
6. sense_key=certain%5:00:00:reliable:00 | definition=reliable in operation or effect | synonyms=sure | examples=a quick and certain remedy; a sure way to distinguish the two
7. sense_key=certain%5:00:00:careful:00 | definition=exercising or taking care great enough to bring assurance | synonyms=sure | examples=be certain to disconnect the iron when you are through; be sure to lock the doors

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "certain" in the given context, let's analyze the context and the provided candidate senses.

The context is a medical instruction regarding the administration of a drug called Alimta, including its dosage, method of administration, and management of side effects. The sentence containing "certain" is: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects."

Let's examine the candidate senses:

1. **definite but not specified or identified** - This sense fits the context because "certain other side effects" refers to side effects that are not specified but are definite or particular in nature.
2. **having or feeling no doubt or uncertainty; confident and assured** - This doesn't fit because the subject is not a person feeling doubt or certainty.
3. **established beyond doubt or question; definitely known** - While this implies a level of certainty, it doesn't directly apply to the context of "certain other side effects" as it more commonly describes facts or states of being known.
4. **certain to occur; destined or inevitable** - This doesn't directly apply because the context doesn't discuss the inevitability of side effects.
5. **established irrevocably** - This sense doesn't fit the context as it refers to something being sealed or decided, which isn't the case with "certain other side effects."
6. **reliable in operation or effect** - This doesn't apply to the context as it describes the reliability of something, not the nature of side effects.
7. **exercising or taking care great enough to bring assurance** - This sense is about being careful or sure in one's actions, which doesn't fit the context.

The use of "certain" in "certain other side effects" implies that there are specific, though unspecified, side effects that warrant a change in treatment. This aligns with the first sense: "definite but not specified or identified."

Therefore, the best indexed sense for "certain" in this context is the first one.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: other
Target surface form: other
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain <t>other</t> side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=other%3:00:00:: | definition=not the same one or ones already mentioned or implied; - the White Queen | examples=today isn't any other day; the construction of highways and other public works
2. sense_key=other%5:00:00:past:00 | definition=recently past | examples=the other evening
3. sense_key=other%5:00:02:past:00 | definition=belonging to the distant past | synonyms=early, former | examples=the early inhabitants of Europe; former generations
4. sense_key=other%5:00:00:strange:00 | definition=very unusual; different in character or quality from the normal or expected; - Lance Morrow | examples=a strange, other dimension...where his powers seemed to fail

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: side_effect
Target surface form: side effects
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other <t>side effects</t>. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=side_effect%1:26:00:: | definition=a secondary and usually adverse effect of a drug or therapy | examples=severe headaches are one of the side effects of the drug
2. sense_key=side_effect%1:19:00:: | definition=any adverse and unwanted secondary effect | synonyms=fallout | examples=a strategy to contain the fallout from the accounting scandal

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "side effects" in the given context, let's analyze the provided information step by step.

1. **Context Analysis**: The text discusses the administration of a drug named Alimta, its dosage, and measures to mitigate its adverse effects. The term "side effects" is used in relation to the drug's administration and its impact on patients.

2. **Candidate Senses Analysis**:
   - **Sense 1**: `side_effect%1:26:00::` is defined as "a secondary and usually adverse effect of a drug or therapy." The example given is "severe headaches are one of the side effects of the drug." This sense directly relates to the adverse effects of medical treatments or drugs.
   - **Sense 2**: `side_effect%1:19:00::` is defined as "any adverse and unwanted secondary effect." It is exemplified by "a strategy to contain the fallout from the accounting scandal," with "fallout" given as a synonym. This sense is broader and not limited to medical contexts.

3. **Choosing the Best Indexed Sense**:
   - The context is clearly medical, discussing a drug (Alimta), its administration, and measures to reduce its adverse effects.
   - The term "side effects" is used in relation to the drug and its management, directly aligning with the first sense, which pertains to the adverse effects of drugs or therapy.
   - The example provided for the first sense ("severe headaches are one of the side effects of the drug") closely matches the context in which "side effects" is used in the given text.

Given the above analysis, the best indexed sense for "side effects" in the provided context is the first sense.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: use
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for <t>use</t> in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=use%1:04:00:: | definition=the act of using | synonyms=usage, utilization, utilisation, employment, exercise | examples=he warned against the use of narcotic drugs; skilled in the utilization of computers
2. sense_key=use%1:07:00:: | definition=what something is used for | synonyms=function, purpose, role | examples=the function of an auger is to bore holes; ballet is beautiful but what use is it?
3. sense_key=use%1:07:02:: | definition=a particular service | examples=he put his knowledge to good use; patrons have their uses
4. sense_key=use%1:22:00:: | definition=(economics) the utilization of economic goods to satisfy needs or in manufacturing | synonyms=consumption, economic consumption, usance, use of goods and services | examples=the consumption of energy has increased steadily
5. sense_key=use%1:04:01:: | definition=(psychology) an automatic pattern of behavior in reaction to a specific situation; may be inherited or acquired through frequent repetition | synonyms=habit | examples=owls have nocturnal habits; she had a habit twirling the ends of her hair
6. sense_key=use%1:04:02:: | definition=exerting shrewd or devious influence especially for one's own advantage | synonyms=manipulation | examples=his manipulation of his friends was scandalous
7. sense_key=use%1:07:03:: | definition=(law) the exercise of the legal right to enjoy the benefits of owning property | synonyms=enjoyment | examples=we were given the use of his boat

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in <t>patients</t> with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "patients" in the given context, let's analyze the provided information.

The context is about medical treatment, specifically the administration of a drug called Alimta, including dosage, potential side effects, and conditions under which it should or should not be used. The term "patients" is used multiple times in relation to receiving the drug, undergoing treatment, and having certain medical conditions or side effects.

The candidate senses are:
1. A person who requires medical care.
2. The semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause.

Let's examine the context and the examples provided for the candidate senses.

The context clearly refers to individuals receiving medical treatment, specifically the drug Alimta. The examples given for the first sense ("the number of emergency patients has grown rapidly") directly relate to individuals requiring medical care.

The second sense refers to a semantic role in a clause, which is more related to grammatical analysis rather than the direct meaning of "patient" in a medical context.

Given the context is about medical treatment and the individuals undergoing this treatment, the most relevant definition is the first one: "a person who requires medical care." This directly corresponds to the usage of "patients" in the provided text.

The first sense is indexed as "1," so the best indexed sense for "patients" in the given context is "1."

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: moderate
Target surface form: moderate
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with <t>moderate</t> or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=moderate%3:00:00:: | definition=being within reasonable or average limits; not excessive or extreme | examples=moderate prices; a moderate income
2. sense_key=moderate%5:00:00:mild:00 | definition=not extreme | synonyms=temperate | examples=a moderate penalty; temperate in his response to criticism
3. sense_key=moderate%5:00:00:temperate:00 | definition=marked by avoidance of extravagance or extremes | synonyms=restrained | examples=moderate in his demands; restrained in his response

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "moderate" in the given context, let's analyze the context and the provided candidate senses.

The context is a medical text discussing the administration and precautions related to the drug Alimta. Specifically, it mentions that Alimta is not recommended for patients with "moderate or severe kidney problems."

Let's examine the candidate senses:

1. The first sense defines "moderate" as being within reasonable or average limits; not excessive or extreme. Examples given include "moderate prices" and "a moderate income." This sense generally refers to something that is average or not extreme in a broad sense.

2. The second sense defines "moderate" as not extreme, with "temperate" given as a synonym. An example is "a moderate penalty." This sense leans towards the idea of something not being at the extremes.

3. The third sense is very similar to the second, defining "moderate" as marked by avoidance of extravagance or extremes, with "restrained" as a synonym. Examples include being "moderate in his demands" or "restrained in his response." This sense also conveys a sense of not being extreme.

In the context provided, "moderate" is used to describe kidney problems, which implies a medical condition. The term "moderate kidney problems" is likely referring to kidney problems that are not mild but also not severe, thus being somewhere in between. This usage aligns with the general idea of being "within reasonable or average limits; not excessive or extreme" as it describes a condition that is not at the extremes (either mild or severe) but rather somewhere in between.

Given the context and the definitions, the first sense ("being within reasonable or average limits; not excessive or extreme") best captures the intended meaning of "moderate" as it is used to describe a middle ground between mild and severe kidney problems.

Therefore, the best indexed sense for "moderate" in this context is the first one.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: severe
Target surface form: severe
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or <t>severe</t> kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=severe%5:00:00:intense:00 | definition=intensely or extremely bad or unpleasant in degree or quality | synonyms=terrible, wicked | examples=severe pain; a severe case of flu
2. sense_key=severe%5:00:00:strong:00 | definition=very strong or vigorous | synonyms=hard, knockout | examples=strong winds; a hard left to the chin
3. sense_key=severe%5:00:00:plain:01 | definition=severely simple | synonyms=austere, stark, stern | examples=a stark interior
4. sense_key=severe%5:00:02:nonindulgent:00 | definition=unsparing and uncompromising in discipline or judgment; - H.G.Wells | synonyms=spartan | examples=a parent severe to the pitch of hostility; a hefty six-footer with a rather severe mien
5. sense_key=severe%5:00:00:critical:03 | definition=causing fear or anxiety by threatening great harm | synonyms=dangerous, grave, grievous, serious, life-threatening | examples=a dangerous operation; a grave situation
6. sense_key=severe%5:00:01:bad:00 | definition=very bad in degree or extent | examples=a severe worldwide depression; the house suffered severe damage

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "severe" in the given context, let's analyze the provided information step by step.

1. **Context Analysis**: The text discusses the usage and administration guidelines for a drug named Alimta, including dosage, potential side effects, and conditions under which its use is not recommended. Specifically, it mentions that Alimta is not recommended for patients with moderate or severe kidney problems.

2. **Understanding the Target Word**: The word "severe" is used to describe the condition of kidney problems.

3. **Examining Candidate Senses**:
   - **1. intense or extremely bad/unpleasant**: This sense is often used to describe conditions or experiences that are very bad or of a high degree (e.g., severe pain, a severe case of flu).
   - **2. very strong or vigorous**: This sense is more about the intensity of something in terms of strength or vigor (e.g., strong winds, a hard left to the chin).
   - **3. severely simple**: This describes something as austere or stark, often in terms of design or simplicity (e.g., a stark interior).
   - **4. unsparing and uncompromising**: This sense relates to being strict or harsh in judgment or discipline (e.g., a parent severe to the pitch of hostility).
   - **5. causing fear/anxiety by threatening great harm**: This is about situations or conditions that are dangerous or serious (e.g., a dangerous operation, a grave situation).
   - **6. very bad in degree or extent**: This describes something as being of a very bad nature or to a significant extent (e.g., a severe worldwide depression, severe damage).

4. **Relating Candidate Senses to the Context**: The context is about medical treatment and the condition of patients, specifically kidney problems. The term "severe" here is used to describe the extent or degree of kidney problems.

5. **Choosing the Best Indexed Sense**:
   - The use of "severe" to describe kidney problems aligns most closely with describing the degree or extent of a medical condition.
   - Senses 1 and 6 both relate to the degree or extent of something being bad or unpleasant.
   - Sense 1 ("intensely or extremely bad or unpleasant in degree or quality") is particularly relevant as it is used to describe medical conditions (e.g., "severe pain", "a severe case of flu").

6. **Decision**: The most appropriate sense for "severe" in the context of describing kidney problems is Sense 1, as it accurately reflects the usage of "severe" to indicate a high degree or intensity of a medical condition.

Therefore, the best indexed sense for "severe" is **1**.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: problem
Target surface form: problems
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney <t>problems</t>. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=problem%1:26:00:: | definition=a state of difficulty that needs to be resolved | synonyms=job | examples=she and her husband are having problems; it is always a job to contact him
2. sense_key=problem%1:10:00:: | definition=a question raised for consideration or solution | examples=our homework consisted of ten problems to solve
3. sense_key=problem%1:09:00:: | definition=a source of difficulty | synonyms=trouble | examples=one trouble after another delayed the job; what's the problem?

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "problems" in the given context, let's analyze the provided information step by step.

1. **Context Analysis**: The text discusses the usage and administration guidelines for a drug named Alimta, including its dosage, potential side effects, and conditions under which its use is not recommended. Specifically, it mentions that Alimta is not recommended for patients with moderate or severe kidney problems.

2. **Understanding the Target Word**: The target word is "problems," which is related to the lemma "problem." The context in which "problems" is used is medical, referring to issues or difficulties related to kidney function.

3. **Examining Candidate Senses**:
   - **Sense 1**: "a state of difficulty that needs to be resolved" with synonyms like "job" and examples such as "she and her husband are having problems." This sense implies a condition or situation that is challenging and needs a solution.
   - **Sense 2**: "a question raised for consideration or solution" with examples like "our homework consisted of ten problems to solve." This sense is more related to mathematical or logical questions to be solved.
   - **Sense 3**: "a source of difficulty" with synonyms like "trouble" and examples such as "one trouble after another delayed the job; what's the problem?" This sense refers to something that causes difficulty or trouble.

4. **Choosing the Best Indexed Sense**:
   - The context is medical and refers to kidney issues or difficulties, which aligns more closely with a condition or state of difficulty rather than a mathematical or logical question.
   - "Kidney problems" is a common medical term used to describe issues or dysfunctions related to the kidneys.
   - Both Sense 1 and Sense 3 seem plausible because they both relate to a state or source of difficulty. However, Sense 3 is more directly related to the concept of "trouble" or a "source of difficulty," which fits well with the medical context of describing kidney issues as a source of trouble or difficulty for patients.

5. **Decision**: Given the context and the definitions, Sense 3 ("a source of difficulty") is the most appropriate. It directly relates to the idea of kidney issues being a source of trouble or difficulty, aligning with the medical context provided.

Therefore, the best indexed sense for "problems" in the given context is Sense 3.

{"sense_index": 3}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: more
Target surface form: more
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For <t>more</t> information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=more%3:00:01:: | definition=(comparative of `much' used with mass nouns) a quantifier meaning greater in size or amount or extent or degree | synonyms=more than | examples=more land; more support
2. sense_key=more%3:00:02:: | definition=(comparative of `many' used with count nouns) quantifier meaning greater in number | examples=a hall with more seats; we have no more bananas

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "more" in the given context, let's analyze the provided information.

The context is: "For more information, see the Summary of Product Characteristics (also part of the EPAR)."

The two candidate senses are:
1. more%3:00:01:: - (comparative of `much' used with mass nouns) a quantifier meaning greater in size or amount or extent or degree. Example: "more land; more support"
2. more%3:00:02:: - (comparative of `many' used with count nouns) quantifier meaning greater in number. Example: "a hall with more seats; we have no more bananas"

The sentence "For more information, see the Summary of Product Characteristics" implies that the reader should refer to the Summary of Product Characteristics for additional or further information. Here, "information" is considered an uncountable or mass noun because it refers to knowledge or facts in a general sense, not to specific, countable pieces of information.

The use of "more" with "information" aligns with the first candidate sense, which involves a comparative of 'much' used with mass nouns, indicating a greater amount or extent.

Therefore, the best indexed sense for "more" in this context is the first one.

{"sense_index": 1}