[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: birth
Target surface form: births
Context:
Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 <t>births</t>. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby.

Candidate senses:
1. sense_key=birth%1:28:00:: | definition=the time when something begins (especially life) | examples=they divorced after the birth of the child; his election signaled the birth of a new age
2. sense_key=birth%1:11:00:: | definition=the event of being born | synonyms=nativity, nascency, nascence | examples=they celebrated the birth of their first child
3. sense_key=birth%1:22:00:: | definition=the process of giving birth | synonyms=parturition, giving birth, birthing
4. sense_key=birth%1:24:00:: | definition=the kinship relation of an offspring to the parents | synonyms=parentage
5. sense_key=birth%1:18:00:: | definition=a baby born; an offspring | examples=the overall rate of incidence of Down's syndrome is one in every 800 births

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "births" in the given context, let's analyze the provided information step by step.

1. **Context Analysis**: The passage discusses the occurrence of retinoblastoma, an eye cancer, in relation to the number of births. The specific sentence mentions that retinoblastoma "occurs about once every 20,000 births."

2. **Understanding the Target Word**: The word "births" is the plural form of "birth." We need to understand how it is used in the given context to choose the correct sense.

3. **Examining Candidate Senses**:
   - **1. sense_key=birth%1:28:00::**: This sense refers to the beginning of something, especially life. While related to the concept of birth, the example given ("they divorced after the birth of the child") indicates it's more about the event or time of being born rather than the count or rate.
   - **2. sense_key=birth%1:11:00::**: This is about the event of being born. The example ("they celebrated the birth of their first child") shows it's used for a specific occurrence of birth, not a statistical rate.
   - **3. sense_key=birth%1:22:00::**: This refers to the process of giving birth. While related, the context provided doesn't directly discuss the process.
   - **4. sense_key=birth%1:24:00::**: This sense is about the kinship relation of an offspring to the parents. The context doesn't directly relate to this meaning.
   - **5. sense_key=birth%1:18:00::**: This defines a baby born or an offspring. The example ("the overall rate of incidence of Down's syndrome is one in every 800 births") directly relates to counting or rate of births, similar to the context given.

4. **Choosing the Best Indexed Sense**:
   - The context is discussing the frequency of retinoblastoma "once every 20,000 births," which implies a statistical rate or count of births.
   - The example given for sense **5. birth%1:18:00::** ("one in every 800 births") matches this usage, indicating it's about counting births or a rate related to births.

5. **Conclusion**: The best indexed sense for "births" in the given context is **5**, as it correctly corresponds to the usage of "births" in a statistical context, referring to the count or rate of babies born.

{"sense_index": 5}


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: know
Target surface form: knew
Context:
Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, <t>knew</t> he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby. Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible last January to find out what threat the Quinlan baby faced.

Candidate senses:
1. sense_key=know%2:31:01:: | definition=be cognizant or aware of a fact or a specific piece of information; possess knowledge or information about | synonyms=cognize, cognise | examples=I know that the President lied to the people; I want to know who is winning the game!
2. sense_key=know%2:31:03:: | definition=know how to do or perform something | examples=She knows how to knit; Does your husband know how to cook?
3. sense_key=know%2:31:02:: | definition=be aware of the truth of something; have a belief or faith in something; regard as true beyond any doubt | examples=I know that I left the key on the table; Galileo knew that the earth moves around the sun
4. sense_key=know%2:31:00:: | definition=be familiar or acquainted with a person or an object | examples=She doesn't know this composer; Do you know my sister?
5. sense_key=know%2:31:04:: | definition=have firsthand knowledge of states, situations, emotions, or sensations | synonyms=experience, live | examples=I know the feeling!; have you ever known hunger?
6. sense_key=know%2:31:06:: | definition=accept (someone) to be what is claimed or accept his power and authority | synonyms=acknowledge, recognize, recognise | examples=The Crown Prince was acknowledged as the true heir to the throne; We do not recognize your gods
7. sense_key=know%2:31:15:: | definition=have fixed in the mind | examples=I know Latin; This student knows her irregular verbs
8. sense_key=know%2:35:00:: | definition=have sexual intercourse with | synonyms=sleep together, roll in the hay, love, make out, make love, sleep with | examples=This student sleeps with everyone in her dorm; Adam knew Eve
9. sense_key=know%2:31:11:: | definition=know the nature or character of | examples=we all knew her as a big show-off
10. sense_key=know%2:31:12:: | definition=be able to distinguish, recognize as being different | examples=The child knows right from wrong
11. sense_key=know%2:31:14:: | definition=perceive as familiar | examples=I know this voice!

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

finish_reason: stop

role: assistant

currency: USD

source: unavailable


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: carry
Target surface form: carried
Context:
Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he <t>carried</t> a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby. Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible last January to find out what threat the Quinlan baby faced.

Candidate senses:
1. sense_key=carry%2:35:02:: | definition=move while supporting, either in a vehicle or in one's hands or on one's body | synonyms=transport | examples=You must carry your camping gear; carry the suitcases to the car
2. sense_key=carry%2:42:01:: | definition=have with oneself; have on one's person | synonyms=pack, take | examples=She always takes an umbrella; I always carry money
3. sense_key=carry%2:38:03:: | definition=transmit or serve as the medium for transmission | synonyms=impart, conduct, transmit, convey, channel | examples=Sound carries well over water; The airwaves carry the sound
4. sense_key=carry%2:32:02:: | definition=serve as a means for expressing something | synonyms=convey, express | examples=The painting of Mary carries motherly love; His voice carried a lot of anger
5. sense_key=carry%2:35:09:: | definition=bear or be able to bear the weight, pressure,or responsibility of | examples=His efforts carried the entire project; How many credits is this student carrying?
6. sense_key=carry%2:35:01:: | definition=support or hold in a certain manner | synonyms=hold, bear | examples=She holds her head high; He carried himself upright
7. sense_key=carry%2:42:03:: | definition=contain or hold; have within | synonyms=hold, bear, contain | examples=The jar carries wine; The canteen holds fresh water
8. sense_key=carry%2:41:00:: | definition=extend to a certain degree | examples=carry too far; She carries her ideas to the extreme
9. sense_key=carry%2:30:05:: | definition=continue or extend | synonyms=extend | examples=The civil war carried into the neighboring province; The disease extended into the remote mountain provinces
10. sense_key=carry%2:42:02:: | definition=be necessarily associated with or result in or involve | examples=This crime carries a penalty of five years in prison
11. sense_key=carry%2:33:01:: | definition=win in an election | examples=The senator carried his home state
12. sense_key=carry%2:31:12:: | definition=include, as on a list | examples=How many people are carried on the payroll?
13. sense_key=carry%2:41:01:: | definition=behave in a certain manner | synonyms=behave, acquit, bear, deport, conduct, comport | examples=She carried herself well; he bore himself with dignity
14. sense_key=carry%2:40:00:: | definition=have on hand | synonyms=stock, stockpile | examples=Do you carry kerosene heaters?
15. sense_key=carry%2:36:00:: | definition=include as the content; broadcast or publicize | synonyms=run | examples=We ran the ad three times; This paper carries a restaurant review
16. sense_key=carry%2:35:08:: | definition=propel, | synonyms=dribble | examples=Carry the ball; dribble the ball
17. sense_key=carry%2:32:07:: | definition=pass on a communication | examples=The news was carried to every village in the province
18. sense_key=carry%2:42:13:: | definition=have as an inherent or characteristic feature or have as a consequence | examples=This new washer carries a two year guarantee; The loan carries a high interest rate
19. sense_key=carry%2:42:15:: | definition=be conveyed over a certain distance | examples=Her voice carries very well in this big opera house
20. sense_key=carry%2:42:14:: | definition=keep up with financial support | examples=The Federal Government carried the province for many years
21. sense_key=carry%2:42:12:: | definition=have or possess something abstract | examples=I carry her image in my mind's eye; I will carry the secret to my grave
22. sense_key=carry%2:42:08:: | definition=be equipped with (a mast or sail) | examples=This boat can only carry a small sail
23. sense_key=carry%2:41:02:: | definition=win approval or support for | synonyms=persuade, sway | examples=Carry all before one; His speech did not sway the voters
24. sense_key=carry%2:41:06:: | definition=compensate for a weaker partner or member by one's own performance | examples=I resent having to carry her all the time
25. sense_key=carry%2:41:12:: | definition=take further or advance | examples=carry a cause
26. sense_key=carry%2:40:10:: | definition=have on the surface or on the skin | examples=carry scars
27. sense_key=carry%2:40:04:: | definition=capture after a fight | examples=The troops carried the town after a brief fight
28. sense_key=carry%2:40:13:: | definition=transfer (entries) from one account book to another | synonyms=post
29. sense_key=carry%2:38:10:: | definition=transfer (a number, cipher, or remainder) to the next column or unit's place before or after, in addition or multiplication | examples=put down 5 and carry 2
30. sense_key=carry%2:38:07:: | definition=pursue a line of scent or be a bearer | examples=the dog was taught to fetch and carry
31. sense_key=carry%2:36:08:: | definition=bear (a crop) | examples=this land does not carry olives
32. sense_key=carry%2:35:12:: | definition=propel or give impetus to | examples=The sudden gust of air propelled the ball to the other side of the fence
33. sense_key=carry%2:34:00:: | definition=drink alcohol without showing ill effects | synonyms=hold | examples=He can hold his liquor; he had drunk more than he could carry
34. sense_key=carry%2:34:01:: | definition=be able to feed | examples=This land will carry ten cows to the acre
35. sense_key=carry%2:33:04:: | definition=have a certain range | examples=This rifle carries for 3,000 feet
36. sense_key=carry%2:33:03:: | definition=cover a certain distance or advance beyond | examples=The drive carried to the green
37. sense_key=carry%2:33:02:: | definition=secure the passage or adoption (of bills and motions) | examples=The motion carried easily
38. sense_key=carry%2:33:12:: | definition=be successful in | examples=She lost the game but carried the match
39. sense_key=carry%2:32:00:: | definition=sing or play against other voices or parts | examples=He cannot carry a tune
40. sense_key=carry%2:29:00:: | definition=be pregnant with | synonyms=have a bun in the oven, bear, gestate, expect | examples=She is bearing his child; The are expecting another child in January

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "carried" in the given context, let's analyze the sentence and the provided candidate senses.

The sentence is: "Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby."

The word "carried" here is used in the context of genetics and inheritance. Mr. Quinlan is said to "carry" a damaged gene, which implies that he has or possesses this gene within his genetic makeup.

Let's examine the candidate senses:

1. The first sense (carry%2:35:02::) involves moving while supporting something, which doesn't fit the context.
2. The second sense (carry%2:42:01::) is about having something with oneself or on one's person, which is closer but not exactly what is meant by "carrying a gene."
3. The third sense (carry%2:38:03::) involves transmitting or serving as a medium for transmission, which could relate to genetics but is more about the action of transmission rather than the state of having a gene.
4. Other senses relate to various meanings such as expressing something, bearing weight or responsibility, containing or holding something, and more.

The most relevant sense here is related to having or possessing something abstract or genetic. Sense 21 (carry%2:42:12::) is defined as "have or possess something abstract" with examples like "I carry her image in my mind's eye." This sense aligns with the idea of "carrying a gene," meaning to have or possess a particular gene.

Thus, the best indexed sense for "carried" in this context is 21.

{"sense_index": 21}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: damaged
Target surface form: damaged
Context:
Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a <t>damaged</t> gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby. Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible last January to find out what threat the Quinlan baby faced.

Candidate senses:
1. sense_key=damaged%3:00:00:: | definition=harmed or injured or spoiled | examples=I won't buy damaged goods; the storm left a wake of badly damaged buildings
2. sense_key=damaged%5:00:00:disreputable:00 | definition=being unjustly brought into disrepute | synonyms=discredited | examples=a discredited politician; her damaged reputation

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "damaged" in the given context, let's analyze the provided information step by step.

1. **Context Analysis**: The passage discusses the genetic basis of cancer, specifically focusing on the role of tumor-suppressor genes and the risk of retinoblastoma, an eye cancer. It mentions that a person born with or acquiring a defective copy of a suppressor gene is more prone to cancer. The term "damaged" is used in the context of a gene being impaired or defective.

2. **Understanding the Target Word**: The word "damaged" is used to describe a gene that Bill Quinlan carries, which is associated with his having lost an eye to retinoblastoma at a young age.

3. **Examining Candidate Senses**:
   - **Sense 1**: This sense is defined as "harmed or injured or spoiled" with examples like "I won't buy damaged goods; the storm left a wake of badly damaged buildings." The usage here relates to something being physically or functionally impaired.
   - **Sense 2**: This sense is defined as "being unjustly brought into disrepute" with synonyms like "discredited" and examples such as "a discredited politician; her damaged reputation." This implies a negative impact on someone's or something's reputation.

4. **Applying Context to Candidate Senses**:
   - The context is about genetic impairment and its relation to cancer. The term "damaged" is used to describe a gene that is functionally impaired or defective, not about reputation.
   - The first sense ("harmed or injured or spoiled") can be metaphorically applied to a gene being impaired or defective, fitting the context of genetic damage or malfunction.

5. **Choosing the Best Indexed Sense**:
   - Given that the context is about genetic impairment and not about reputation, **Sense 1** is the most appropriate. The gene is "damaged" in the sense that it is not functioning correctly due to some form of genetic impairment.

6. **Returning the Answer**:
   - The sense keys provided are indexed starting from 1. Since we've identified that Sense 1 is the most appropriate, the index is 1.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: lose
Target surface form: lost
Context:
Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having <t>lost</t> an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby. Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible last January to find out what threat the Quinlan baby faced.

Candidate senses:
1. sense_key=lose%2:40:02:: | definition=fail to keep or to maintain; cease to have, either physically or in an abstract sense | examples=She lost her purse when she left it unattended on her seat
2. sense_key=lose%2:33:00:: | definition=fail to win | examples=We lost the battle but we won the war
3. sense_key=lose%2:37:00:: | definition=suffer the loss of a person through death or removal | examples=She lost her husband in the war; The couple that wanted to adopt the child lost her when the biological parents claimed her
4. sense_key=lose%2:35:00:: | definition=place (something) where one cannot find it again | synonyms=misplace, mislay | examples=I misplaced my eyeglasses
5. sense_key=lose%2:40:01:: | definition=miss from one's possessions; lose sight of | examples=I've lost my glasses again!
6. sense_key=lose%2:39:00:: | definition=allow to go out of sight | examples=The detective lost the man he was shadowing after he had to stop at a red light
7. sense_key=lose%2:40:06:: | definition=fail to make money in a business; make a loss or fail to profit | synonyms=turn a loss | examples=I lost thousands of dollars on that bad investment!; The company turned a loss after the first year
8. sense_key=lose%2:40:00:: | definition=fail to get or obtain | examples=I lost the opportunity to spend a year abroad
9. sense_key=lose%2:33:01:: | definition=retreat | synonyms=fall back, drop off, fall behind, recede
10. sense_key=lose%2:39:01:: | definition=fail to perceive or to catch with the senses or the mind | synonyms=miss | examples=I missed that remark; She missed his point
11. sense_key=lose%2:30:03:: | definition=be set at a disadvantage | synonyms=suffer | examples=This author really suffers in translation

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "lost" in the given context, let's analyze the sentence and the provided candidate senses.

The sentence is: "Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby."

Here, "lost" is used in the context of losing a body part (an eye) due to a medical condition (a rare tumor). The phrase "lost an eye" is idiomatic and means to have an eye removed or to lose the use of an eye.

Let's examine the candidate senses:

1. Fail to keep or to maintain; cease to have, either physically or in an abstract sense. (Examples: She lost her purse when she left it unattended on her seat)
2. Fail to win. (Examples: We lost the battle but we won the war)
3. Suffer the loss of a person through death or removal. (Examples: She lost her husband in the war; The couple that wanted to adopt the child lost her when the biological parents claimed her)
4. Place (something) where one cannot find it again. (Synonyms: misplace, mislay; Examples: I misplaced my eyeglasses)
5. Miss from one's possessions; lose sight of. (Examples: I've lost my glasses again!)
6. Allow to go out of sight. (Examples: The detective lost the man he was shadowing after he had to stop at a red light)
7. Fail to make money in a business; make a loss or fail to profit. (Synonyms: turn a loss; Examples: I lost thousands of dollars on that bad investment!; The company turned a loss after the first year)
8. Fail to get or obtain. (Examples: I lost the opportunity to spend a year abroad)
9. Retreat. (Synonyms: fall back, drop off, fall behind, recede)
10. Fail to perceive or to catch with the senses or the mind. (Synonyms: miss; Examples: I missed that remark; She missed his point)
11. Be set at a disadvantage. (Synonyms: suffer; Examples: This author really suffers in translation)

The usage of "lost" in the given context best aligns with sense 1: "fail to keep or to maintain; cease to have, either physically or in an abstract sense." The sentence implies that Mr. Quinlan ceased to have the use of an eye due to a tumor, which fits the definition of losing something physically.

Therefore, the best indexed sense for "lost" in the context is sense 1.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: eye
Target surface form: eye
Context:
Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an <t>eye</t> to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby. Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible last January to find out what threat the Quinlan baby faced.

Candidate senses:
1. sense_key=eye%1:08:00:: | definition=the organ of sight | synonyms=oculus, optic
2. sense_key=eye%1:09:00:: | definition=good discernment (either visually or as if visually) | examples=she has an eye for fresh talent; he has an artist's eye
3. sense_key=eye%1:09:01:: | definition=attention to what is seen | examples=he tried to catch her eye
4. sense_key=eye%1:15:00:: | definition=an area that is approximately central within some larger region | synonyms=center, centre, middle, heart | examples=it is in the center of town; they ran forward into the heart of the struggle
5. sense_key=eye%1:06:00:: | definition=a small hole or loop (as in a needle) | examples=the thread wouldn't go through the eye

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: only
Target surface form: only
Context:
Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was <t>only</t> two months old -- after his mother had suffered the same fate when she was a baby. Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible last January to find out what threat the Quinlan baby faced.

Candidate senses:
1. sense_key=only%4:02:02:: | definition=and nothing more | synonyms=merely, simply, just, but | examples=I was merely asking; it is simply a matter of time
2. sense_key=only%4:02:01:: | definition=without any others being included or involved | synonyms=entirely, exclusively, solely, alone | examples=was entirely to blame; a school devoted entirely to the needs of problem children
3. sense_key=only%4:02:00:: | definition=with nevertheless the final result | examples=He arrived only to find his wife dead; We won only to lose again in the next round
4. sense_key=only%4:02:04:: | definition=in the final outcome | examples=These news will only make you more upset
5. sense_key=only%4:02:06:: | definition=except that | examples=It was the same story; only this time she came out better
6. sense_key=only%4:02:03:: | definition=never except when | synonyms=only if, only when | examples=call me only if your cold gets worse
7. sense_key=only%4:02:05:: | definition=as recently as | examples=I spoke to him only an hour ago

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "only" in the given context, let's analyze the sentence and the provided candidate senses.

The sentence is: "Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby."

Here, "only" is used to indicate that Mr. Quinlan was merely or just two months old when he lost an eye to the tumor. The context suggests that the focus is on the young age at which this event occurred.

Let's examine the candidate senses:

1. "and nothing more" - This sense aligns with the idea that Mr. Quinlan was just or merely two months old, emphasizing the young age.
2. "without any others being included or involved" - This doesn't directly fit as the context isn't about excluding other ages or involving only this age exclusively.
3. "with nevertheless the final result" - This doesn't fit the context as there's no contrast or unexpected outcome related to his age.
4. "in the final outcome" - This sense doesn't apply as the sentence isn't discussing a final outcome related to "only."
5. "except that" - This is not relevant as the sentence isn't setting up a contrast with "except that."
6. "never except when" - This doesn't fit as the context isn't about a condition or exception related to "only."
7. "as recently as" - This sense fits well because it indicates that losing an eye happened as recently as two months old, relative to the time of speaking or the context's reference point.

The use of "only" here indicates that the event (losing an eye) occurred at a very young age, "two months old," which can be interpreted as "as recently as" in the context of a person's lifetime, highlighting how early in life it happened.

Therefore, the best indexed sense for "only" in this context is related to indicating a recent or early occurrence in a person's life.

The best answer is: {"sense_index": 7}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: mother
Target surface form: mother
Context:
Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his <t>mother</t> had suffered the same fate when she was a baby. Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible last January to find out what threat the Quinlan baby faced.

Candidate senses:
1. sense_key=mother%1:18:00:: | definition=a woman who has given birth to a child (also used as a term of address to your mother) | synonyms=female parent | examples=the mother of three children
2. sense_key=mother%1:27:00:: | definition=a stringy slimy substance consisting of yeast cells and bacteria; forms during fermentation and is added to cider or wine to produce vinegar
3. sense_key=mother%1:18:02:: | definition=a term of address for an elderly woman
4. sense_key=mother%1:18:01:: | definition=a term of address for a mother superior
5. sense_key=mother%1:09:00:: | definition=a condition that is the inspiration for an activity or situation | examples=necessity is the mother of invention

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: suffer
Target surface form: suffered
Context:
Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had <t>suffered</t> the same fate when she was a baby. Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible last January to find out what threat the Quinlan baby faced.

Candidate senses:
1. sense_key=suffer%2:39:01:: | definition=undergo or be subjected to | synonyms=endure | examples=He suffered the penalty; Many saints suffered martyrdom
2. sense_key=suffer%2:29:01:: | definition=undergo (as of injuries and illnesses) | synonyms=sustain, have, get | examples=She suffered a fracture in the accident; He had an insulin shock after eating three candy bars
3. sense_key=suffer%2:37:00:: | definition=experience (emotional) pain | examples=Every time her husband gets drunk, she suffers
4. sense_key=suffer%2:31:00:: | definition=put up with something or somebody unpleasant | synonyms=digest, endure, stick out, stomach, bear, stand | examples=I cannot bear his constant criticism; The new secretary had to endure a lot of unprofessional remarks
5. sense_key=suffer%2:30:00:: | definition=get worse | examples=His grades suffered
6. sense_key=suffer%2:29:00:: | definition=feel pain or be in pain | synonyms=hurt
7. sense_key=suffer%2:39:00:: | definition=feel physical pain | synonyms=hurt, ache | examples=Were you hurting after the accident?
8. sense_key=suffer%2:29:03:: | definition=feel unwell or uncomfortable | examples=She is suffering from the hot weather
9. sense_key=suffer%2:42:04:: | definition=be given to | examples=She suffers from a tendency to talk too much
10. sense_key=suffer%2:39:02:: | definition=undergo or suffer | synonyms=meet | examples=meet a violent death; suffer a terrible fate
11. sense_key=suffer%2:30:02:: | definition=be set at a disadvantage | synonyms=lose | examples=This author really suffers in translation

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "suffered" in the given context, let's analyze the sentence and the provided candidate senses.

The sentence is: "...after his mother had suffered the same fate when she was a baby."

Here, "suffered the same fate" implies undergoing or experiencing the same unfortunate event or condition, which in this context is losing an eye to retinoblastoma.

Let's examine the candidate senses:

1. Undergo or be subjected to - This sense fits the context as "suffered the same fate" means undergoing the same unfortunate event.
2. Undergo (as of injuries and illnesses) - While this could potentially fit, it's more specific to injuries and illnesses, and "fate" is broader.
3. Experience (emotional) pain - The context doesn't specifically indicate emotional pain; it's about undergoing a specific fate.
4. Put up with something or somebody unpleasant - This doesn't fit as "suffered the same fate" doesn't mean tolerating something unpleasant but rather experiencing the same event.
5. Get worse - This doesn't apply to the context.
6. Feel pain or be in pain - Too general and doesn't directly relate to "fate."
7. Feel physical pain - Similar to 6, it's about pain, not directly about "fate."
8. Feel unwell or uncomfortable - Not directly relevant to "suffered the same fate."
9. Be given to - This sense doesn't fit the context.
10. Undergo or suffer - This is a good fit as it directly relates to experiencing or undergoing something, in this case, "the same fate."
11. Be set at a disadvantage - While related to negative outcomes, it's not the best fit for "suffered the same fate."

The phrase "suffered the same fate" aligns closely with sense 1 ("undergo or be subjected to") and sense 10 ("undergo or suffer"). However, "suffered the same fate" is a more idiomatic expression that aligns with sense 10, which is about undergoing or suffering something, and is directly related to the example given ("suffer a terrible fate").

Thus, the best sense for "suffered" in the given context is sense 10.

{"sense_index": 10}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: same
Target surface form: same
Context:
Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the <t>same</t> fate when she was a baby. Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible last January to find out what threat the Quinlan baby faced.

Candidate senses:
1. sense_key=same%3:00:02:: | definition=same in identity | examples=the same man I saw yesterday; never wore the same dress twice
2. sense_key=same%3:00:00:: | definition=closely similar or comparable in kind or quality or quantity or degree | examples=curtains the same color as the walls; two girls of the same age
3. sense_key=same%3:00:04:: | definition=equal in amount or value | synonyms=like | examples=like amounts; equivalent amounts
4. sense_key=same%5:00:00:unchanged:00 | definition=unchanged in character or nature | examples=the village stayed the same; his attitude is the same as ever

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "same" in the given context, let's analyze the sentence and the provided candidate senses.

The sentence is: "...after his mother had suffered the same fate when she was a baby."

Here, "same" is used to indicate that Bill Quinlan and his mother experienced the same event or condition, which is losing an eye to the rare tumor retinoblastoma.

1. The first sense suggests "same in identity," with examples like "the same man I saw yesterday." This implies an identical entity, not just a similar event or condition.

2. The second sense is "closely similar or comparable in kind or quality or quantity or degree." An example given is "curtains the same color as the walls." This sense implies a similarity rather than an exact identity.

3. The third sense refers to being "equal in amount or value," with synonyms like "like" or "equivalent." This is not directly relevant to the context of experiencing a condition or event.

4. The fourth sense is "unchanged in character or nature," as in "the village stayed the same." This implies a lack of change over time, not similarity between two different entities' experiences.

In the given context, "same fate" refers to Bill Quinlan and his mother both losing an eye to retinoblastoma. This is not about the exact same event in terms of time or identity but rather about the similarity in the kind of event or condition they experienced.

Therefore, the best sense is the one that indicates a close similarity or comparability in kind or quality, which is the second sense.

{"sense_index": 2}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: fate
Target surface form: fate
Context:
Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same <t>fate</t> when she was a baby. Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible last January to find out what threat the Quinlan baby faced.

Candidate senses:
1. sense_key=fate%1:11:00:: | definition=an event (or a course of events) that will inevitably happen in the future | synonyms=destiny
2. sense_key=fate%1:18:00:: | definition=the ultimate agency regarded as predetermining the course of events (often personified as a woman) | synonyms=destiny | examples=we are helpless in the face of destiny
3. sense_key=fate%1:26:00:: | definition=your overall circumstances or condition in life (including everything that happens to you) | synonyms=fortune, destiny, luck, lot, circumstances, portion | examples=whatever my fortune may be; deserved a better fate

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "fate" in the given context, let's analyze the context and the provided candidate senses.

The context is about a family's history with a specific type of cancer, retinoblastoma, and how genetic testing can predict the risk of this cancer in their offspring. The sentence where "fate" appears is: "...after his mother had suffered the same fate when she was a baby." Here, "fate" refers to the event of losing an eye to the rare tumor.

Let's examine the candidate senses:

1. The first sense defines "fate" as "an event (or a course of events) that will inevitably happen in the future." The synonym given is "destiny." The context suggests that the mother's experience (losing an eye to the tumor) is being referenced as something that happened, not necessarily as something inevitable for the future, although it implies a shared risk or condition.

2. The second sense regards "fate" as "the ultimate agency regarded as predetermining the course of events (often personified as a woman)." While this sense also involves destiny, it implies a more abstract, personified force controlling events. The context doesn't directly suggest that "fate" is being used to refer to such an agency; rather, it focuses on a specific event.

3. The third sense defines "fate" as "your overall circumstances or condition in life (including everything that happens to you)." The synonyms include "fortune, destiny, luck, lot, circumstances, portion." The example given is "deserved a better fate," indicating a broader condition or outcome in life.

In the given sentence, "fate" refers to the specific event of losing an eye to retinoblastoma, which happened to both Bill Quinlan and his mother. This usage aligns most closely with the first sense, as it refers to a specific event (or course of events) that has occurred, rather than the overall condition or an abstract predetermining agency. The event (losing an eye to the tumor) is a significant and specific occurrence that has befallen both Bill and his mother, making it an "event that will inevitably happen" in the context of their shared genetic condition, or more accurately, an event that has happened due to their condition.

Therefore, the best indexed sense for "fate" in this context is the first one.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: baby
Target surface form: baby
Context:
Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a <t>baby</t>. Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible last January to find out what threat the Quinlan baby faced.

Candidate senses:
1. sense_key=baby%1:18:00:: | definition=a very young child (birth to 1 year) who has not yet begun to walk or talk | synonyms=babe, infant | examples=the baby began to cry again; she held the baby in her arms
2. sense_key=baby%1:18:01:: | definition=the youngest member of a group (not necessarily young) | examples=the baby of the family; the baby of the Supreme Court
3. sense_key=baby%1:18:03:: | definition=an immature childish person | synonyms=child | examples=he remained a child in practical matters as long as he lived; stop being a baby!
4. sense_key=baby%1:18:04:: | definition=an unborn child; a human fetus | examples=I felt healthy and very feminine carrying the baby; it was great to feel my baby moving about inside
5. sense_key=baby%1:18:02:: | definition=(slang) sometimes used as a term of address for attractive young women | synonyms=babe, sister
6. sense_key=baby%1:05:00:: | definition=a very young mammal | examples=baby rabbits
7. sense_key=baby%1:04:00:: | definition=a project of personal concern to someone | examples=this project is his baby

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: isolation
Target surface form: isolation
Context:
A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby. Because of the <t>isolation</t> of the retinoblastoma tumor-suppressor gene, it became possible last January to find out what threat the Quinlan baby faced. A test using new "genetic probes "showed that little Will Quinlan had not inherited a damaged retinoblastoma supressor gene and, therefore, faced no more risk than other children of developing the rare cancer.

Candidate senses:
1. sense_key=isolation%1:26:00:: | definition=a state of separation between persons or groups
2. sense_key=isolation%1:12:00:: | definition=a feeling of being disliked and alone
3. sense_key=isolation%1:04:00:: | definition=the act of isolating something; setting something apart from others | synonyms=closing off
4. sense_key=isolation%1:22:00:: | definition=(psychiatry) a defense mechanism in which memory of an unacceptable act or impulse is separated from the emotion originally associated with it
5. sense_key=isolation%1:04:01:: | definition=a country's withdrawal from international politics | examples=he opposed a policy of American isolation

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "isolation" in the given context, let's analyze the provided information step by step.

1. **Context Analysis**: The passage discusses the identification of a gene related to retinoblastoma, an eye cancer, and how genetic testing can determine if a child has inherited a damaged gene that increases the risk of this cancer. It mentions the "isolation of the retinoblastoma tumor-suppressor gene" as a crucial step that made it possible to assess the risk for the Quinlan baby.

2. **Understanding the Target Word**: The word "isolation" here is used in the context of genetic research and the identification of a specific gene.

3. **Examining Candidate Senses**:
   - **1. a state of separation between persons or groups**: This doesn't directly relate to genetic research or gene identification.
   - **2. a feeling of being disliked and alone**: This is more related to emotional or social isolation, not relevant to the context.
   - **3. the act of isolating something; setting something apart from others**: This sense is relevant because "isolation" in genetics often refers to the process of identifying and separating a specific gene from others, making it a potential candidate.
   - **4. (psychiatry) a defense mechanism**: This is unrelated to the context of genetics and gene identification.
   - **5. a country's withdrawal from international politics**: This is also unrelated to the context.

4. **Relating to Synonyms and Examples**: The synonym "closing off" for sense 3 supports the idea that isolating a gene involves separating or identifying it distinctly from other genes, which fits the context.

5. **Choosing the Best Indexed Sense**: Given the context is about genetic research and the identification of a specific gene, the most appropriate sense is **3. the act of isolating something; setting something apart from others**.

Therefore, the best indexed sense for "isolation" in the given context is {"sense_index": 3}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: become
Target surface form: became
Context:
A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby. Because of the isolation of the retinoblastoma tumor-suppressor gene, it <t>became</t> possible last January to find out what threat the Quinlan baby faced. A test using new "genetic probes "showed that little Will Quinlan had not inherited a damaged retinoblastoma supressor gene and, therefore, faced no more risk than other children of developing the rare cancer.

Candidate senses:
1. sense_key=become%2:30:00:: | definition=enter or assume a certain state or condition | synonyms=go, get | examples=He became annoyed when he heard the bad news; It must be getting more serious
2. sense_key=become%2:42:01:: | definition=undergo a change or development | synonyms=turn | examples=The water turned into ice; Her former friend became her worst enemy
3. sense_key=become%2:42:00:: | definition=come into existence | examples=What becomes has duration
4. sense_key=become%2:42:03:: | definition=enhance the appearance of | synonyms=suit | examples=Mourning becomes Electra; This behavior doesn't suit you!

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: possible
Target surface form: possible
Context:
A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby. Because of the isolation of the retinoblastoma tumor-suppressor gene, it became <t>possible</t> last January to find out what threat the Quinlan baby faced. A test using new "genetic probes "showed that little Will Quinlan had not inherited a damaged retinoblastoma supressor gene and, therefore, faced no more risk than other children of developing the rare cancer.

Candidate senses:
1. sense_key=possible%3:00:00:: | definition=capable of happening or existing | examples=a breakthrough may be possible next year; anything is possible
2. sense_key=possible%3:00:04:: | definition=existing in possibility | synonyms=potential | examples=a potential problem; possible uses of nuclear power

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "possible" in the given context, let's analyze the provided information step by step.

1. **Context Analysis**: The passage discusses the advancements in genetic testing for cancer susceptibility, specifically focusing on retinoblastoma, an eye cancer. It mentions that due to the isolation of the retinoblastoma tumor-suppressor gene, it became possible to assess the risk for the Quinlan baby.

2. **Understanding the Target Word**: The word "possible" is used in the sentence, "Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible last January to find out what threat the Quinlan baby faced." Here, "possible" refers to the feasibility or capability of determining the threat or risk faced by the Quinlan baby.

3. **Examining Candidate Senses**:
   - **Sense 1**: "capable of happening or existing" with examples like "a breakthrough may be possible next year; anything is possible." This sense aligns with the context of something being feasible or capable of being done, in this case, determining the risk faced by the Quinlan baby.
   - **Sense 2**: "existing in possibility" with synonyms like "potential" and examples such as "a potential problem; possible uses of nuclear power." This sense refers to something that might exist or happen in the future.

4. **Choosing the Best Indexed Sense**:
   - The context indicates that the isolation of the gene made it feasible or capable of being done to determine the risk for the Quinlan baby. This aligns with the first sense, which is about capability or feasibility.
   - The use of "became possible" directly relates to the capability of performing an action (assessing the risk) that was not possible before.

5. **Conclusion**: The best indexed sense for "possible" in the given context is the first one, as it correctly captures the notion of something being feasible or capable of being done due to certain advancements or conditions.

Therefore, the response should be: {"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: last
Target surface form: last
Context:
A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby. Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible <t>last</t> January to find out what threat the Quinlan baby faced. A test using new "genetic probes "showed that little Will Quinlan had not inherited a damaged retinoblastoma supressor gene and, therefore, faced no more risk than other children of developing the rare cancer.

Candidate senses:
1. sense_key=last%5:00:00:past:00 | definition=immediately past | examples=last Thursday; the last chapter we read
2. sense_key=last%3:00:00:: | definition=coming after all others in time or space or degree or being the only one remaining | examples=the last time I saw Paris; the last day of the month
3. sense_key=last%5:00:00:closing:00 | definition=occurring at or forming an end or termination | synonyms=concluding, final, terminal | examples=his concluding words came as a surprise; the final chapter
4. sense_key=last%5:00:00:unlikely:00 | definition=most unlikely or unsuitable | examples=the last person we would have suspected; the last man they would have chosen for the job
5. sense_key=last%5:00:00:dying:00 | definition=occurring at the time of death | examples=his last words; the last rites
6. sense_key=last%5:00:00:ultimate:00 | definition=conclusive in a process or progression | synonyms=final, net | examples=the final answer; a last resort
7. sense_key=last%5:00:00:high:02 | definition=highest in extent or degree | synonyms=utmost | examples=to the last measure of human endurance; whether they were accomplices in the last degree or a lesser one was...to be determined individually
8. sense_key=last%5:00:00:unalterable:00 | definition=not to be altered or undone | synonyms=final | examples=the judge's decision is final; the arbiter will have the last say
9. sense_key=last%5:00:00:worst:00 | definition=lowest in rank or importance | synonyms=last-place, lowest | examples=last prize; in last place

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: find_out
Target surface form: find out
Context:
A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby. Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible last January to <t>find out</t> what threat the Quinlan baby faced. A test using new "genetic probes "showed that little Will Quinlan had not inherited a damaged retinoblastoma supressor gene and, therefore, faced no more risk than other children of developing the rare cancer.

Candidate senses:
1. sense_key=find_out%2:32:00:: | definition=establish after a calculation, investigation, experiment, survey, or study | synonyms=determine, find, ascertain | examples=find the product of two numbers; The physicist who found the elusive particle won the Nobel Prize
2. sense_key=find_out%2:31:00:: | definition=get to know or become aware of, usually accidentally | synonyms=learn, hear, get word, get wind, pick up, get a line | examples=I learned that she has two grown-up children; I see that you have been promoted
3. sense_key=find_out%2:32:01:: | definition=find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, see, ascertain, watch, learn | examples=I want to see whether she speaks French; See whether it works
4. sense_key=find_out%2:31:01:: | definition=trap; especially in an error or in a reprehensible act | synonyms=catch out | examples=He was caught out; She was found out when she tried to cash the stolen checks

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for "find out" in the given context, let's analyze the sentence and the provided candidate senses.

The context is about Bill and Bonnie Quinlan, whose child, Will Quinlan, underwent a test to determine if he had inherited a damaged retinoblastoma suppressor gene. The sentence of interest is: "Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible last January to find out what threat the Quinlan baby faced."

1. The first sense is related to establishing something after a calculation, investigation, etc. While this involves investigation, it's more about concluding a process with a specific result.

2. The second sense involves getting to know or becoming aware of something, usually accidentally. The context doesn't indicate that the information was obtained accidentally.

3. The third sense is about finding out, learning, or determining with certainty, usually by making an inquiry or other effort. The context involves a test using "genetic probes" to determine the risk faced by the Quinlan baby, indicating an active effort to discover or determine something.

4. The fourth sense is related to trapping someone in an error or reprehensible act, which doesn't fit the context.

Given the context, where a test was conducted to determine the risk faced by the Quinlan baby, the most appropriate sense is the third one. It involves determining or finding out with certainty through an effort (the genetic test), which aligns with the provided context.

{"sense_index": 3}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: threat
Target surface form: threat
Context:
A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby. Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible last January to find out what <t>threat</t> the Quinlan baby faced. A test using new "genetic probes "showed that little Will Quinlan had not inherited a damaged retinoblastoma supressor gene and, therefore, faced no more risk than other children of developing the rare cancer.

Candidate senses:
1. sense_key=threat%1:26:00:: | definition=something that is a source of danger | synonyms=menace | examples=earthquakes are a constant threat in Japan
2. sense_key=threat%1:10:00:: | definition=a warning that something unpleasant is imminent | examples=they were under threat of arrest
3. sense_key=threat%1:10:01:: | definition=declaration of an intention or a determination to inflict harm on another | examples=his threat to kill me was quite explicit
4. sense_key=threat%1:18:00:: | definition=a person who inspires fear or dread | synonyms=terror, scourge | examples=he was the terror of the neighborhood

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "threat" in the given context, let's analyze the context and the provided candidate senses.

The context discusses the risk of a child inheriting a damaged gene that could lead to retinoblastoma, an eye cancer. The text mentions that due to genetic testing, it became possible to determine what "threat" the Quinlan baby faced regarding this cancer.

1. The first sense defines "threat" as "something that is a source of danger" with the synonym "menace" and an example related to natural disasters being a danger. This sense is plausible because the damaged gene is a source of danger or risk for cancer.

2. The second sense defines "threat" as "a warning that something unpleasant is imminent." The context does not directly imply that a warning was given; rather, it discusses the risk or danger posed by a genetic condition.

3. The third sense defines "threat" as "declaration of an intention or a determination to inflict harm on another." This does not fit the context because there's no declaration of intention to harm.

4. The fourth sense defines "threat" as "a person who inspires fear or dread" with synonyms like "terror" or "scourge." The context is not describing a person as the threat but rather the risk or danger posed by a genetic condition.

Given the context, the word "threat" refers to the danger or risk posed by the possibility of having inherited a damaged retinoblastoma suppressor gene. The closest definition is the first sense: "something that is a source of danger." The Quinlan baby's risk of developing retinoblastoma due to potentially inheriting a damaged gene is the "threat" being discussed. Thus, the best fit is the first sense.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: baby
Target surface form: baby
Context:
A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby. Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible last January to find out what threat the Quinlan <t>baby</t> faced. A test using new "genetic probes "showed that little Will Quinlan had not inherited a damaged retinoblastoma supressor gene and, therefore, faced no more risk than other children of developing the rare cancer.

Candidate senses:
1. sense_key=baby%1:18:00:: | definition=a very young child (birth to 1 year) who has not yet begun to walk or talk | synonyms=babe, infant | examples=the baby began to cry again; she held the baby in her arms
2. sense_key=baby%1:18:01:: | definition=the youngest member of a group (not necessarily young) | examples=the baby of the family; the baby of the Supreme Court
3. sense_key=baby%1:18:03:: | definition=an immature childish person | synonyms=child | examples=he remained a child in practical matters as long as he lived; stop being a baby!
4. sense_key=baby%1:18:04:: | definition=an unborn child; a human fetus | examples=I felt healthy and very feminine carrying the baby; it was great to feel my baby moving about inside
5. sense_key=baby%1:18:02:: | definition=(slang) sometimes used as a term of address for attractive young women | synonyms=babe, sister
6. sense_key=baby%1:05:00:: | definition=a very young mammal | examples=baby rabbits
7. sense_key=baby%1:04:00:: | definition=a project of personal concern to someone | examples=this project is his baby

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: face
Target surface form: faced
Context:
A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby. Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible last January to find out what threat the Quinlan baby <t>faced</t>. A test using new "genetic probes "showed that little Will Quinlan had not inherited a damaged retinoblastoma supressor gene and, therefore, faced no more risk than other children of developing the rare cancer.

Candidate senses:
1. sense_key=face%2:32:00:: | definition=deal with (something unpleasant) head on | synonyms=confront, face up | examples=You must confront your problems; He faced the terrible consequences of his mistakes
2. sense_key=face%2:33:00:: | definition=oppose, as in hostility or a competition | synonyms=confront | examples=You must confront your opponent; Jackson faced Smith in the boxing ring
3. sense_key=face%2:42:00:: | definition=be oriented in a certain direction, often with respect to another reference point; be opposite to | synonyms=front, look | examples=The house looks north; My backyard look onto the pond
4. sense_key=face%2:42:02:: | definition=be opposite | examples=the facing page; the two sofas face each other
5. sense_key=face%2:38:00:: | definition=turn so as to face; turn the face in a certain direction | examples=Turn and face your partner now
6. sense_key=face%2:32:03:: | definition=present somebody with something, usually to accuse or criticize | synonyms=confront, present | examples=We confronted him with the evidence; He was faced with all the evidence and could no longer deny his actions
7. sense_key=face%2:39:04:: | definition=turn so as to expose the face | examples=face a playing card
8. sense_key=face%2:35:00:: | definition=line the edge (of a garment) with a different material | examples=face the lapels of the jacket
9. sense_key=face%2:35:01:: | definition=cover the front or surface of | examples=The building was faced with beautiful stones

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "faced" in the given context, let's analyze the provided information step by step.

1. **Context Analysis**: The passage discusses genetic testing for cancer susceptibility, specifically retinoblastoma, an eye cancer. It mentions a couple, Bill and Bonnie Quinlan, and their concern about their child inheriting a damaged gene that could lead to this cancer. The text states that due to the isolation of the retinoblastoma tumor-suppressor gene, it became possible to determine the threat their baby faced.

2. **Understanding the Target Word**: The target word is "faced," which is a form of the lemma "face." We need to understand how "faced" is used in the context. The sentence is: "it became possible last January to find out what threat the Quinlan baby faced."

3. **Analyzing Candidate Senses**:
   - **1. deal with (something unpleasant) head on**: This involves confronting a problem directly. The example given is "You must confront your problems; He faced the terrible consequences of his mistakes." The usage in the context ("what threat the Quinlan baby faced") suggests that the baby is confronting or dealing with a potential problem (the risk of cancer), which aligns with this sense.
   - **2. oppose, as in hostility or a competition**: This involves being in opposition to someone or something, often in a competitive or hostile manner. The context doesn't suggest a direct opposition or competition.
   - **3. be oriented in a certain direction**: This involves being positioned or directed towards something. While this is a possible meaning of "face," it doesn't directly fit the context of confronting a threat.
   - **4. be opposite**: This involves being directly across from something. It doesn't fit the context of the sentence.
   - **5. turn so as to face; turn the face in a certain direction**: This involves changing direction to face something or someone. It doesn't directly apply to the context.
   - **6. present somebody with something, usually to accuse or criticize**: This involves presenting someone with evidence or a situation, often negatively. While it involves confrontation, the context is more about assessing a risk than presenting evidence.
   - Other senses (7, 8, 9) relate to turning something to expose its face, lining edges of garments, or covering surfaces, which are not relevant to the context.

4. **Choosing the Best Indexed Sense**:
   - The sentence "it became possible last January to find out what threat the Quinlan baby faced" implies understanding or confronting a potential problem (the risk of cancer).
   - Sense 1 ("deal with (something unpleasant) head on") fits this context as it involves confronting or dealing with a problem (the threat of cancer).
   - Sense 6 ("present somebody with something, usually to accuse or criticize") is also a possibility because it involves being faced with a situation (a threat), but the primary focus is on the baby being at risk, not being presented with evidence.

Given the context and the examples, **Sense 1** is the most appropriate. It correctly captures the idea of confronting or dealing with a potential problem or threat.

Therefore, the best indexed sense for "faced" in the given context is **1**.

The response should be in the format: {"sense_index": 1}.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: face
Target surface form: faced
Context:
A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby. Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible last January to find out what threat the Quinlan baby <t>faced</t>. A test using new "genetic probes "showed that little Will Quinlan had not inherited a damaged retinoblastoma supressor gene and, therefore, faced no more risk than other children of developing the rare cancer.

Candidate senses:
1. sense_key=face%2:32:00:: | definition=deal with (something unpleasant) head on | synonyms=confront, face up | examples=You must confront your problems; He faced the terrible consequences of his mistakes
2. sense_key=face%2:33:00:: | definition=oppose, as in hostility or a competition | synonyms=confront | examples=You must confront your opponent; Jackson faced Smith in the boxing ring
3. sense_key=face%2:42:00:: | definition=be oriented in a certain direction, often with respect to another reference point; be opposite to | synonyms=front, look | examples=The house looks north; My backyard look onto the pond
4. sense_key=face%2:42:02:: | definition=be opposite | examples=the facing page; the two sofas face each other
5. sense_key=face%2:38:00:: | definition=turn so as to face; turn the face in a certain direction | examples=Turn and face your partner now
6. sense_key=face%2:32:03:: | definition=present somebody with something, usually to accuse or criticize | synonyms=confront, present | examples=We confronted him with the evidence; He was faced with all the evidence and could no longer deny his actions
7. sense_key=face%2:39:04:: | definition=turn so as to expose the face | examples=face a playing card
8. sense_key=face%2:35:00:: | definition=line the edge (of a garment) with a different material | examples=face the lapels of the jacket
9. sense_key=face%2:35:01:: | definition=cover the front or surface of | examples=The building was faced with beautiful stones

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

[Assistant]
To determine the best indexed sense for the target word "faced" in the given context, let's analyze the provided information step by step.

1. **Context Analysis**: The passage discusses genetic testing for cancer susceptibility, specifically retinoblastoma, an eye cancer. It mentions a couple, Bill and Bonnie Quinlan, and their concern about their child inheriting a damaged gene that could lead to this cancer. The text states that due to the isolation of the retinoblastoma tumor-suppressor gene, it became possible to determine the threat their baby faced.

2. **Understanding the Target Word**: The target word is "faced," which is a form of the lemma "face." We need to understand how "faced" is used in the context. The sentence is: "it became possible last January to find out what threat the Quinlan baby faced."

3. **Analyzing Candidate Senses**:
   - **1. deal with (something unpleasant) head on**: This involves confronting a problem directly. The example given is "You must confront your problems; He faced the terrible consequences of his mistakes." The usage in the context ("what threat the Quinlan baby faced") suggests that the baby is confronting or dealing with a potential problem (the risk of cancer), which aligns with this sense.
   - **2. oppose, as in hostility or a competition**: This involves being in opposition to someone or something, often in a competitive or hostile manner. The context doesn't suggest a direct opposition or competition.
   - **3. be oriented in a certain direction**: This involves being positioned or directed towards something. While this is a possible meaning of "face," it doesn't directly fit the context of confronting a threat.
   - **4. be opposite**: This involves being directly across from something. It doesn't fit the context of the sentence.
   - **5. turn so as to face; turn the face in a certain direction**: This involves changing direction to face something or someone. It doesn't directly apply to the context.
   - **6. present somebody with something, usually to accuse or criticize**: This involves presenting someone with evidence or a situation, often negatively. While it involves confrontation, the context is more about assessing a risk than presenting evidence.
   - Other senses (7, 8, 9) relate to turning something to expose its face, lining edges of garments, or covering surfaces, which are not relevant to the context.

4. **Choosing the Best Indexed Sense**:
   - The sentence "it became possible last January to find out what threat the Quinlan baby faced" implies understanding or confronting a potential problem (the risk of cancer).
   - Sense 1 ("deal with (something unpleasant) head on") fits this context as it involves confronting or dealing with a problem (the threat of cancer).
   - Sense 6 ("present somebody with something, usually to accuse or criticize") is also a possibility because it involves being faced with a situation (a threat), but the primary focus is on the baby being at risk, not being presented with evidence.

Given the context and the examples, **Sense 1** is the most appropriate. It correctly captures the idea of confronting or dealing with a potential problem or threat.

Therefore, the best indexed sense for "faced" in the given context is **1**.

The response should be in the format: {"sense_index": 1}.

{"sense_index": 1}

[User] Your previous answer was invalid. Choose one candidate index between 1 and 9. Return only valid JSON exactly like {"sense_index": 1}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: using
Context:
Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby. Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible last January to find out what threat the Quinlan baby faced. A test <t>using</t> new "genetic probes "showed that little Will Quinlan had not inherited a damaged retinoblastoma supressor gene and, therefore, faced no more risk than other children of developing the rare cancer. "It made our New Year, "says Mr. Quinlan.

Candidate senses:
1. sense_key=use%2:34:01:: | definition=put into service; make work or employ for a particular purpose or for its inherent or natural purpose | synonyms=utilize, utilise, apply, employ | examples=use your head!; we only use Spanish at home
2. sense_key=use%2:34:02:: | definition=take or consume (regularly or habitually) | synonyms=habituate | examples=She uses drugs rarely
3. sense_key=use%2:34:00:: | definition=use up, consume fully | synonyms=expend | examples=The legislature expended its time on school questions
4. sense_key=use%2:41:14:: | definition=seek or achieve an end by using to one's advantage | examples=She uses her influential friends to get jobs; The president's wife used her good connections
5. sense_key=use%2:41:04:: | definition=avail oneself to | synonyms=practice, apply | examples=apply a principle; practice a religion
6. sense_key=use%2:41:03:: | definition=habitually do something (use only in the past tense) | examples=She used to call her mother every week but now she calls only occasionally; I used to get sick when I ate in that dining hall

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "using" in the given context, let's analyze the sentence and the provided candidate senses.

The sentence is: "A test using new 'genetic probes' showed that little Will Quinlan had not inherited a damaged retinoblastoma supressor gene..."

Here, "using" is related to the employment or application of "new genetic probes" in a test. The context suggests that the test was conducted or performed by employing or utilizing these genetic probes.

Let's examine the candidate senses:

1. The first sense is defined as "put into service; make work or employ for a particular purpose or for its inherent or natural purpose." The synonyms include "utilize," "utilise," "apply," and "employ." The example given is "use your head!"; "we only use Spanish at home." This sense aligns with employing something for a particular purpose, which fits the context of using genetic probes in a test.

2. The second sense involves "tak[ing] or consum[ing] (regularly or habitually)" and is related to habituating. The example provided is "She uses drugs rarely." This doesn't fit the context of using genetic probes.

3. The third sense is about "us[ing] up, consum[ing] fully" with the synonym "expend." The example is "The legislature expended its time on school questions." This doesn't directly relate to the application or employment of genetic probes in a test.

4. The fourth sense is "seek or achieve an end by using to one's advantage." The examples given are "She uses her influential friends to get jobs; The president's wife used her good connections." This involves using something or someone to gain an advantage, which is not directly related to the context.

5. The fifth sense is "avail oneself to" with synonyms "practice" and "apply." The example is "apply a principle; practice a religion." While "apply" is a relevant synonym, the context is more about the employment of genetic probes rather than availing oneself to a principle or practice.

6. The sixth sense is about "habitually do[ing] something" and is used only in the past tense. The examples are "She used to call her mother every week but now she calls only occasionally; I used to get sick when I ate in that dining hall." This doesn't fit the context.

Given the context and the definitions, the most appropriate sense is the first one, as it involves employing or utilizing something (genetic probes) for a particular purpose (the test).

Therefore, the best indexed sense for "using" in the given context is the first sense.

{"sense_index": 1}