[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: team
Target surface form: teams
Context:
It was the first time anyone had showed that the loss of both copies of the same gene could lead to the eruption of a cancer. "It was extraordinarily satisfying, "says Dr. Knudson, now at Fox Chase Cancer Research Center in Philadelphia. "I was convinced that what was true of retinoblastoma would be true for all cancers. "It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research <t>teams</t> in 1984 to report dual chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer.

Candidate senses:
1. sense_key=team%1:14:00:: | definition=a cooperative unit (especially in sports) | synonyms=squad
2. sense_key=team%1:14:01:: | definition=two or more draft animals that work together to pull something

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: report
Target surface form: report
Context:
It was the first time anyone had showed that the loss of both copies of the same gene could lead to the eruption of a cancer. "It was extraordinarily satisfying, "says Dr. Knudson, now at Fox Chase Cancer Research Center in Philadelphia. "I was convinced that what was true of retinoblastoma would be true for all cancers. "It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to <t>report</t> dual chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer.

Candidate senses:
1. sense_key=report%2:32:00:: | definition=to give an account or representation of in words | synonyms=describe, account | examples=Discreet Italian police described it in a manner typically continental
2. sense_key=report%2:32:04:: | definition=announce as the result of an investigation or experience or finding | examples=Dozens of incidents of wife beatings are reported daily in this city; The team reported significant advances in their research
3. sense_key=report%2:32:03:: | definition=announce one's presence | examples=I report to work every day at 9 o'clock
4. sense_key=report%2:32:01:: | definition=make known to the authorities | examples=One student reported the other to the principal
5. sense_key=report%2:32:13:: | definition=be responsible for reporting the details of, as in journalism | synonyms=cover | examples=Snow reported on China in the 1950's; The cub reporter covered New York City
6. sense_key=report%2:32:02:: | definition=complain about; make a charge against | examples=I reported her to the supervisor

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "report" in the given context, let's analyze the context and the provided candidate senses.

The context is about Dr. Vogelstein and his research team announcing or publishing their findings regarding dual chromosome losses for a rare childhood cancer. The sentence specifically mentions, "His was one of two research teams in 1984 to report dual chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor."

Let's examine the candidate senses:

1. The first sense involves giving an account or representation of something in words. While this is a broad definition that could encompass reporting findings, the specific action of announcing the result of an investigation fits more precisely with another sense.

2. The second sense is to announce as the result of an investigation or experience or finding. The examples provided, such as "Dozens of incidents of wife beatings are reported daily in this city; The team reported significant advances in their research," closely match the context of Dr. Vogelstein's team announcing their research findings.

3. The third sense involves announcing one's presence, which doesn't fit the context of reporting research findings.

4. The fourth sense is to make known to the authorities, which also doesn't directly fit the context since reporting research findings is not necessarily about informing authorities.

5. The fifth sense involves being responsible for reporting the details of something, as in journalism. While this involves reporting, the context is more about scientific research than journalistic reporting.

6. The sixth sense is to complain about or make a charge against someone, which doesn't fit the context at all.

Given the context and the examples provided for the candidate senses, the second sense ("announce as the result of an investigation or experience or finding") is the most appropriate. This corresponds to the indexed sense associated with the definition and examples that match the usage of "report" in the given context.

Thus, the best indexed sense for "report" in this context is the one that matches the action of announcing research findings.

{"sense_index": 2}

finish_reason: stop

role: assistant

currency: USD

source: unavailable


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: dual
Target surface form: dual
Context:
It was the first time anyone had showed that the loss of both copies of the same gene could lead to the eruption of a cancer. "It was extraordinarily satisfying, "says Dr. Knudson, now at Fox Chase Cancer Research Center in Philadelphia. "I was convinced that what was true of retinoblastoma would be true for all cancers. "It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report <t>dual</t> chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer.

Candidate senses:
1. sense_key=dual%5:00:00:multiple:00 | definition=consisting of or involving two parts or components usually in pairs | synonyms=double, duple | examples=an egg with a double yolk; a double (binary) star
2. sense_key=dual%5:00:02:multiple:00 | definition=having more than one decidedly dissimilar aspects or qualities; ; - R.W.Emerson; -Frederick Harrison | synonyms=double, twofold, treble, threefold | examples=a double (or dual) role for an actor; the office of a clergyman is twofold; public preaching and private influence
3. sense_key=dual%5:00:00:plural:00 | definition=a grammatical number category referring to two items or units as opposed to one item (singular) or more than two items (plural) | examples=ancient Greek had the dual form but it has merged with the plural form in modern Greek

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "dual" in the given context, let's analyze the provided information step by step.

1. **Context Analysis**: The passage discusses genetic research related to cancer, specifically mentioning "dual chromosome losses" in the context of a rare childhood cancer called Wilm's tumor. The term "dual" here refers to the loss of two copies (or parts) of chromosomes.

2. **Candidate Senses Analysis**:
   - **Sense 1**: "consisting of or involving two parts or components usually in pairs." The synonyms provided are "double, duple," and an example is given as "an egg with a double yolk; a double (binary) star." This sense aligns with the context of "dual chromosome losses," indicating the involvement of two parts or components (in this case, chromosome copies).
   - **Sense 2**: "having more than one decidedly dissimilar aspects or qualities." The synonyms are "double, twofold, treble, threefold," with examples like "a double (or dual) role for an actor." While this sense also involves the concept of "two," it implies dissimilar aspects or qualities, which isn't directly relevant to the context of chromosome losses.
   - **Sense 3**: Refers to a "grammatical number category referring to two items or units." This is unrelated to the context of genetic or biological discussion.

3. **Choosing the Best Indexed Sense**:
   - The context clearly discusses a scientific finding related to genetics and chromosome losses.
   - "Dual chromosome losses" directly implies the involvement of two chromosome copies or parts, aligning with the first sense.
   - The first sense ("consisting of or involving two parts or components usually in pairs") is the most relevant because it directly relates to the concept of having or involving two parts (chromosome copies in this context).

4. **Conclusion**: The most appropriate sense for "dual" in the given context is the first sense, which corresponds to the concept of involving two parts or components.

Therefore, the best indexed sense is: {"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: loss
Target surface form: losses
Context:
It was the first time anyone had showed that the loss of both copies of the same gene could lead to the eruption of a cancer. "It was extraordinarily satisfying, "says Dr. Knudson, now at Fox Chase Cancer Research Center in Philadelphia. "I was convinced that what was true of retinoblastoma would be true for all cancers. "It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome <t>losses</t> for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer.

Candidate senses:
1. sense_key=loss%1:21:01:: | definition=something that is lost | examples=the car was a total loss; loss of livestock left the rancher bankrupt
2. sense_key=loss%1:22:00:: | definition=gradual decline in amount or activity | examples=weight loss; a serious loss of business
3. sense_key=loss%1:04:00:: | definition=the act of losing someone or something | examples=everyone expected him to win so his loss was a shock
4. sense_key=loss%1:07:00:: | definition=the disadvantage that results from losing something | synonyms=deprivation | examples=his loss of credibility led to his resignation; losing him is no great deprivation
5. sense_key=loss%1:11:01:: | definition=the experience of losing a loved one | examples=he sympathized on the loss of their grandfather
6. sense_key=loss%1:21:00:: | definition=the amount by which the cost of a business exceeds its revenue | synonyms=red ink, red | examples=the company operated at a loss last year; the company operated in the red last year
7. sense_key=loss%1:11:00:: | definition=military personnel lost by death or capture | synonyms=personnel casualty
8. sense_key=loss%1:11:02:: | definition=euphemistic expressions for death | synonyms=passing, departure, exit, expiration, going, release | examples=thousands mourned his passing

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: childhood
Target surface form: childhood
Context:
It was the first time anyone had showed that the loss of both copies of the same gene could lead to the eruption of a cancer. "It was extraordinarily satisfying, "says Dr. Knudson, now at Fox Chase Cancer Research Center in Philadelphia. "I was convinced that what was true of retinoblastoma would be true for all cancers. "It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome losses for a rare <t>childhood</t> cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer.

Candidate senses:
1. sense_key=childhood%1:28:00:: | definition=the time of person's life when they are a child
2. sense_key=childhood%1:26:00:: | definition=the state of a child between infancy and adolescence | synonyms=puerility

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "childhood" in the given context, let's analyze the provided information.

The context discusses medical research related to cancers, specifically mentioning "a rare childhood cancer of the kidney called Wilm's tumor." Here, "childhood" is used to describe the type of cancer, indicating it occurs in children.

The two candidate senses for "childhood" are:
1. the time of a person's life when they are a child
2. the state of a child between infancy and adolescence

The first sense, "the time of a person's life when they are a child," fits well in the context because it describes a period or stage of life. When saying "childhood cancer," it implies a cancer that occurs during the period of life known as childhood.

The second sense, "the state of a child between infancy and adolescence," refers more to the condition or status of being a child, which is less directly related to the concept of a specific period or stage of life in this context.

In the given sentence, "childhood" is used as an adjective to describe the type of cancer (Wilm's tumor), indicating it is a cancer that occurs during the time of life when individuals are children. Thus, the most appropriate sense is the one that refers to the time or period of being a child.

Given the definitions and the context, the first sense ("the time of a person's life when they are a child") is the most appropriate.

Therefore, the best indexed sense for "childhood" is: {"sense_index": 1}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
It was the first time anyone had showed that the loss of both copies of the same gene could lead to the eruption of a cancer. "It was extraordinarily satisfying, "says Dr. Knudson, now at Fox Chase Cancer Research Center in Philadelphia. "I was convinced that what was true of retinoblastoma would be true for all cancers. "It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome losses for a rare childhood <t>cancer</t> of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: call
Target surface form: called
Context:
It was the first time anyone had showed that the loss of both copies of the same gene could lead to the eruption of a cancer. "It was extraordinarily satisfying, "says Dr. Knudson, now at Fox Chase Cancer Research Center in Philadelphia. "I was convinced that what was true of retinoblastoma would be true for all cancers. "It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome losses for a rare childhood cancer of the kidney <t>called</t> Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer.

Candidate senses:
1. sense_key=call%2:32:02:: | definition=assign a specified (usually proper) proper name to | synonyms=name | examples=They named their son David; The new school was named after the famous Civil Rights leader
2. sense_key=call%2:32:00:: | definition=ascribe a quality to or give a name of a common noun that reflects a quality | examples=He called me a bastard; She called her children lazy and ungrateful
3. sense_key=call%2:32:01:: | definition=get or try to get into communication (with someone) by telephone | synonyms=telephone, call up, phone, ring | examples=I tried to call you all night; Take two aspirin and call me in the morning
4. sense_key=call%2:32:09:: | definition=utter a sudden loud cry | synonyms=shout, shout out, cry, yell, scream, holler | examples=she cried with pain when the doctor inserted the needle; I yelled to her from the window but she couldn't hear me
5. sense_key=call%2:32:05:: | definition=order, request, or command to come | synonyms=send for | examples=She was called into the director's office; Call the police!
6. sense_key=call%2:41:00:: | definition=pay a brief visit | synonyms=visit, call in | examples=The mayor likes to call on some of the prominent citizens
7. sense_key=call%2:41:04:: | definition=call a meeting; invite or command to meet | examples=The Wannsee Conference was called to discuss the `Final Solution'; The new dean calls meetings every week
8. sense_key=call%2:32:13:: | definition=read aloud to check for omissions or absentees | examples=Call roll
9. sense_key=call%2:32:04:: | definition=send a message or attempt to reach someone by radio, phone, etc.; make a signal to in order to transmit a message | examples=Hawaii is calling!; A transmitter in Samoa was heard calling
10. sense_key=call%2:32:03:: | definition=utter a characteristic note or cry | examples=bluejays called to one another
11. sense_key=call%2:42:09:: | definition=stop or postpone because of adverse conditions, such as bad weather | examples=call a football game
12. sense_key=call%2:41:14:: | definition=greet, as with a prescribed form, title, or name | synonyms=address | examples=He always addresses me with `Sir'; Call me Mister
13. sense_key=call%2:41:12:: | definition=make a stop in a harbour | examples=The ship will call in Honolulu tomorrow
14. sense_key=call%2:40:09:: | definition=demand payment of (a loan) | synonyms=call in | examples=Call a loan
15. sense_key=call%2:40:05:: | definition=make a demand, as for a card or a suit or a show of hands | synonyms=bid | examples=He called his trump
16. sense_key=call%2:38:00:: | definition=give the calls (to the dancers) for a square dance | synonyms=call off
17. sense_key=call%2:32:06:: | definition=indicate a decision in regard to | examples=call balls and strikes behind the plate
18. sense_key=call%2:32:10:: | definition=make a prediction about; tell in advance | synonyms=predict, foretell, prognosticate, forebode, anticipate, promise | examples=Call the outcome of an election
19. sense_key=call%2:32:12:: | definition=require the presentation of for redemption before maturation | examples=Call a bond
20. sense_key=call%2:32:07:: | definition=challenge (somebody) to make good on a statement; charge with or censure for an offense | examples=He deserves to be called on that
21. sense_key=call%2:32:08:: | definition=declare in the capacity of an umpire or referee | examples=call a runner out
22. sense_key=call%2:32:11:: | definition=lure by imitating the characteristic call of an animal | examples=Call ducks
23. sense_key=call%2:32:15:: | definition=order or request or give a command for | examples=The unions called a general strike for Sunday
24. sense_key=call%2:32:14:: | definition=order, summon, or request for a specific duty or activity, work, role | examples=He was already called 4 times for jury duty; They called him to active military duty
25. sense_key=call%2:31:13:: | definition=utter in a loud voice or announce | examples=He called my name; The auctioneer called the bids
26. sense_key=call%2:31:00:: | definition=challenge the sincerity or truthfulness of | examples=call the speaker on a question of fact
27. sense_key=call%2:31:05:: | definition=consider or regard as being | examples=I would not call her beautiful
28. sense_key=call%2:29:05:: | definition=rouse somebody from sleep with a call | examples=I was called at 5 A.M. this morning

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: turn_to
Target surface form: turned
Context:
"It was extraordinarily satisfying, "says Dr. Knudson, now at Fox Chase Cancer Research Center in Philadelphia. "I was convinced that what was true of retinoblastoma would be true for all cancers. "It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next <t>turned</t> his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer. He believed colon cancer might also arise from multiple "hits "on cancer suppressor genes, because it often seems to develop in stages.

Candidate senses:
1. sense_key=turn_to%2:32:01:: | definition=speak to | synonyms=address | examples=He addressed the crowd outside the window
2. sense_key=turn_to%2:30:00:: | definition=direct one's interest or attention towards; go into | examples=The pedophile turned to boys for satisfaction; People turn to mysticism at the turn of a millennium

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "turned" in the given context, let's analyze the provided information step by step.

1. **Context Analysis**: The sentence where "turned" appears is: "Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer." The context is about Dr. Vogelstein shifting his focus towards colon cancer after his work on another type of cancer.

2. **Understanding the Target Lemma**: The target lemma is "turn_to," and its surface form in the context is "turned." The phrase "turned his attention" is an idiomatic expression indicating a shift in focus or direction of one's interest.

3. **Examining Candidate Senses**:
   - **Sense 1**: "speak to" with the definition "speak to" and synonyms like "address." The example given is "He addressed the crowd outside the window." This sense does not fit the context because "turned his attention" does not mean speaking to someone or something.
   - **Sense 2**: "direct one's interest or attention towards; go into" with examples like "The pedophile turned to boys for satisfaction; People turn to mysticism at the turn of a millennium." This sense matches the context because "turned his attention" means directing his interest or focus towards colon cancer.

4. **Choosing the Best Indexed Sense**: Based on the analysis, the context matches **Sense 2** because it involves directing one's attention or interest towards something (in this case, colon cancer). The examples and the definition provided for Sense 2 align with the usage of "turned his attention" in the given sentence.

5. **Returning the Answer**: Since Sense 2 is the correct interpretation and it is listed as the second candidate sense, and given that indexing starts at 1, the correct index is 2.

{"sense_index": 2}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: second
Target surface form: second
Context:
"It was extraordinarily satisfying, "says Dr. Knudson, now at Fox Chase Cancer Research Center in Philadelphia. "I was convinced that what was true of retinoblastoma would be true for all cancers. "It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the <t>second</t> biggest cancer killer in the U.S. after lung cancer. He believed colon cancer might also arise from multiple "hits "on cancer suppressor genes, because it often seems to develop in stages.

Candidate senses:
1. sense_key=second%5:00:00:ordinal:00 | definition=coming next after the first in position in space or time or degree or magnitude | synonyms=2nd, 2d
2. sense_key=second%3:00:00:: | definition=a part or voice or instrument or orchestra section lower in pitch than or subordinate to the first | examples=second flute; the second violins

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: big
Target surface form: biggest
Context:
"It was extraordinarily satisfying, "says Dr. Knudson, now at Fox Chase Cancer Research Center in Philadelphia. "I was convinced that what was true of retinoblastoma would be true for all cancers. "It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second <t>biggest</t> cancer killer in the U.S. after lung cancer. He believed colon cancer might also arise from multiple "hits "on cancer suppressor genes, because it often seems to develop in stages.

Candidate senses:
1. sense_key=big%3:00:01:: | definition=above average in size or number or quantity or magnitude or extent | synonyms=large | examples=a large city; set out for the big city
2. sense_key=big%5:00:00:important:00 | definition=significant | examples=graduation was a big day in his life
3. sense_key=big%5:00:00:intense:00 | definition=very intense | synonyms=bad | examples=a bad headache; in a big rage
4. sense_key=big%5:00:00:loud:00 | definition=loud and firm | examples=a big voice; big bold piano sounds
5. sense_key=big%5:00:00:conspicuous:00 | definition=conspicuous in position or importance | synonyms=large, prominent | examples=a big figure in the movement; big man on campus
6. sense_key=big%5:00:00:intemperate:00 | definition=prodigious | synonyms=heavy | examples=big spender; big eater
7. sense_key=big%5:00:02:proud:00 | definition=exhibiting self-importance | synonyms=boastful, braggart, bragging, braggy, cock-a-hoop, crowing | examples=big talk
8. sense_key=big%5:00:00:proud:00 | definition=feeling self-importance | synonyms=swelled, vainglorious | examples=too big for his britches; had a swelled head
9. sense_key=big%5:00:00:mature:01 | definition=(of animals) fully developed | synonyms=adult, full-grown, fully grown, grown, grownup | examples=an adult animal; a grown woman
10. sense_key=big%5:00:00:heavy:08 | definition=marked by intense physical force | examples=a big wind
11. sense_key=big%5:00:00:generous:02 | definition=generous and understanding and tolerant | synonyms=large, magnanimous | examples=a heart big enough to hold no grudges; that's very big of you to be so forgiving
12. sense_key=big%5:00:00:generous:01 | definition=given or giving freely | synonyms=bighearted, bounteous, bountiful, freehanded, handsome, giving | examples=was a big tipper; the bounteous goodness of God
13. sense_key=big%5:00:00:pregnant:00 | definition=in an advanced stage of pregnancy | synonyms=enceinte, expectant, gravid, great, large, heavy | examples=was big with child; was great with child

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "biggest" in the given context, let's analyze the sentence and the provided candidate senses.

The sentence is: "Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer."

Here, "biggest" is used to describe the magnitude or extent of colon cancer as a killer in the U.S., comparing it to lung cancer.

Let's examine the candidate senses:

1. above average in size or number or quantity or magnitude or extent
   - This sense fits well because "biggest" is comparing the magnitude (in terms of the number of deaths caused) of colon cancer to lung cancer.

2. significant
   - While "biggest" does imply significance, the primary comparison here is in terms of quantity (number of deaths), not just significance.

3. very intense
   - This doesn't directly apply to the context of being a "cancer killer," which is more about the number of deaths than the intensity of the disease.

4. loud and firm
   - This doesn't fit the context as "biggest cancer killer" refers to the quantity or magnitude, not the loudness or firmness.

5. conspicuous in position or importance
   - While being the second biggest killer is important, the term "biggest" here primarily refers to the magnitude or extent (number of deaths).

6. prodigious
   - This could potentially fit, as it implies something is large or considerable in amount or degree. However, it's not as directly related to the simple comparison of magnitude as sense 1.

7. exhibiting self-importance
   - This doesn't fit the context as "biggest" is not describing a behavior or attitude of self-importance.

8. feeling self-importance
   - Similar to sense 7, this doesn't apply as the context is not about feelings or attitudes.

9. (of animals) fully developed
   - This doesn't fit as "biggest" is not describing the developmental stage of cancer or any animals.

10. marked by intense physical force
    - This doesn't directly apply as the context is about the number of deaths caused by a cancer, not the physical force associated with it.

11. generous and understanding and tolerant
    - This doesn't fit the context as "biggest" is not describing a personal trait or attitude.

12. given or giving freely
    - This doesn't apply as the context is not about generosity.

13. in an advanced stage of pregnancy
    - This is unrelated to the context.

Given the context and the analysis, the best fit for "biggest" is sense 1, as it refers to "above average in size or number or quantity or magnitude or extent," which aligns with comparing the magnitude (number of deaths caused) of colon cancer to lung cancer.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
"It was extraordinarily satisfying, "says Dr. Knudson, now at Fox Chase Cancer Research Center in Philadelphia. "I was convinced that what was true of retinoblastoma would be true for all cancers. "It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest <t>cancer</t> killer in the U.S. after lung cancer. He believed colon cancer might also arise from multiple "hits "on cancer suppressor genes, because it often seems to develop in stages.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: killer
Target surface form: killer
Context:
"It was extraordinarily satisfying, "says Dr. Knudson, now at Fox Chase Cancer Research Center in Philadelphia. "I was convinced that what was true of retinoblastoma would be true for all cancers. "It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer <t>killer</t> in the U.S. after lung cancer. He believed colon cancer might also arise from multiple "hits "on cancer suppressor genes, because it often seems to develop in stages.

Candidate senses:
1. sense_key=killer%1:18:00:: | definition=someone who causes the death of a person or animal | synonyms=slayer
2. sense_key=killer%1:26:00:: | definition=the causal agent resulting in death | synonyms=cause of death | examples=heart disease is the biggest killer in the United States
3. sense_key=killer%1:09:00:: | definition=a difficulty that is hard to deal with | examples=that exam was a real killer
4. sense_key=killer%1:05:00:: | definition=predatory black-and-white toothed whale with large dorsal fin; common in cold seas | synonyms=killer whale, orca, grampus, sea wolf, Orcinus orca

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: u.s.
Target surface form: U.S.
Context:
"It was extraordinarily satisfying, "says Dr. Knudson, now at Fox Chase Cancer Research Center in Philadelphia. "I was convinced that what was true of retinoblastoma would be true for all cancers. "It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the <t>U.S.</t> after lung cancer. He believed colon cancer might also arise from multiple "hits "on cancer suppressor genes, because it often seems to develop in stages.

Candidate senses:
1. sense_key=u.s.%1:14:00:: | definition=the executive and legislative and judicial branches of the federal government of the United States | synonyms=United States government, United States, U.S. government
2. sense_key=us%1:15:00:: | definition=North American republic containing 50 states - 48 conterminous states in North America plus Alaska in northwest North America and the Hawaiian Islands in the Pacific Ocean; achieved independence in 1776 | synonyms=United States, United States of America, America, the States, USA

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "U.S." in the given context, let's analyze the information provided.

The context discusses cancer research, specifically mentioning Dr. Vogelstein's work at Johns Hopkins Medical School and his focus on colon cancer, which is noted as the second biggest cancer killer in the U.S. after lung cancer. The sentence is referring to a geographical or national entity in relation to cancer statistics.

The two candidate senses provided are:
1. The United States government.
2. The United States of America as a geographical and political entity.

Let's examine the context and the candidate senses:
- The context is discussing a national statistic regarding cancer, which implies a reference to a country or nation.
- The phrase "the second biggest cancer killer in the U.S." is used to provide a statistic about the prevalence of colon cancer relative to other cancers within a specific geographical or national boundary.

Using the context, examples, and synonyms:
- Sense 1 refers to the U.S. government, which doesn't directly fit the context of discussing cancer statistics across the population.
- Sense 2 refers to the United States of America, which aligns with discussing national health statistics.

Therefore, the best sense for "U.S." in this context is the one referring to the country, which is the second candidate sense.

{"sense_index": 2}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: believe
Target surface form: believed
Context:
"I was convinced that what was true of retinoblastoma would be true for all cancers. "It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer. He <t>believed</t> colon cancer might also arise from multiple "hits "on cancer suppressor genes, because it often seems to develop in stages. It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring.

Candidate senses:
1. sense_key=believe%2:31:00:: | definition=accept as true; take to be true | examples=I believed his report; We didn't believe his stories from the War
2. sense_key=believe%2:31:04:: | definition=judge or regard; look upon; judge | synonyms=think, consider, conceive | examples=I think he is very smart; I believe her to be very smart
3. sense_key=believe%2:31:03:: | definition=be confident about something | synonyms=trust | examples=I believe that he will come back from the war
4. sense_key=believe%2:31:01:: | definition=follow a credo; have a faith; be a believer | examples=When you hear his sermons, you will be able to believe, too
5. sense_key=believe%2:31:02:: | definition=credit with veracity | examples=You cannot believe this man; Should we believe a publication like the National Enquirer?

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "believed" in the given context, let's analyze the provided information step by step.

1. **Context Analysis**: The passage discusses Dr. Vogelstein's research and his thoughts on the relationship between certain genetic factors and the development of various cancers. It mentions that Dr. Vogelstein "believed Dr. Knudson was right" and later that "He believed colon cancer might also arise from multiple 'hits' on cancer suppressor genes."

2. **Understanding the Target Word**: The target word is "believed," which is a form of the lemma "believe." The task is to identify the sense in which "believed" is used in the given context.

3. **Examining Candidate Senses**:
   - **1. accept as true; take to be true**: This involves accepting something as factual or true without necessarily having absolute proof. The example given is "I believed his report."
   - **2. judge or regard; look upon; judge**: This involves having an opinion or conception about something or someone. The synonyms provided are "think," "consider," and "conceive," with an example being "I believe her to be very smart."
   - **3. be confident about something**: This sense is about having confidence or faith in something happening or being true. The synonym given is "trust," and an example is "I believe that he will come back from the war."
   - **4. follow a credo; have a faith; be a believer**: This involves having a religious faith or belief. An example is "When you hear his sermons, you will be able to believe, too."
   - **5. credit with veracity**: This means to believe someone or something because you think they are honest or truthful. An example given is "You cannot believe this man."

4. **Applying Context to Candidate Senses**:
   - The first instance, "Dr. Vogelstein believed Dr. Knudson was right," suggests that Dr. Vogelstein accepted Dr. Knudson's views or findings as true.
   - The second instance, "He believed colon cancer might also arise from multiple 'hits' on cancer suppressor genes," indicates Dr. Vogelstein's opinion or hypothesis about the potential cause of colon cancer.

5. **Choosing the Best Indexed Sense**:
   - Both instances of "believed" in the passage relate to Dr. Vogelstein's acceptance or consideration of certain scientific hypotheses or findings as true or plausible.
   - Sense 1 ("accept as true; take to be true") fits the first instance well because it involves accepting Dr. Knudson's views as true.
   - Sense 2 ("judge or regard; look upon; judge") is also relevant, especially for the second instance, as it involves Dr. Vogelstein's opinion or hypothesis about colon cancer.

6. **Decision**:
   - Upon closer inspection, both instances of "believed" are more aligned with having an opinion or hypothesis based on available information rather than merely accepting something as true without question. Dr. Vogelstein is forming a judgment or hypothesis about the causes of colon cancer based on his understanding and research.
   - The use of "might also arise" in the second instance indicates a considered opinion or hypothesis rather than a statement of fact or an expression of faith.

7. **Conclusion**:
   - The best fit for the usage of "believed" in the given context is **Sense 2: judge or regard; look upon; judge**, as it involves Dr. Vogelstein's considered opinion or hypothesis about scientific matters.

Therefore, the JSON response is: {"sense_index": 2}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: arise
Target surface form: arise
Context:
"I was convinced that what was true of retinoblastoma would be true for all cancers. "It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer. He believed colon cancer might also <t>arise</t> from multiple "hits "on cancer suppressor genes, because it often seems to develop in stages. It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring.

Candidate senses:
1. sense_key=arise%2:42:00:: | definition=come into existence; take on form or shape | synonyms=originate, rise, develop, uprise, spring up, grow | examples=A new religious movement originated in that country; a love that sprang up from friendship
2. sense_key=arise%2:42:01:: | definition=originate or come into being | synonyms=come up, bob up | examples=a question arose
3. sense_key=arise%2:38:00:: | definition=rise to one's feet | synonyms=rise, uprise, get up, stand up | examples=The audience got up and applauded
4. sense_key=arise%2:30:00:: | definition=result or issue | synonyms=come up | examples=A slight unpleasantness arose from this discussion
5. sense_key=arise%2:38:04:: | definition=move upward | synonyms=rise, lift, move up, go up, come up, uprise | examples=The fog lifted; The smoke arose from the forest fire
6. sense_key=arise%2:41:00:: | definition=take part in a rebellion; renounce a former allegiance | synonyms=rebel, rise, rise up
7. sense_key=arise%2:29:00:: | definition=get up and out of bed | synonyms=get up, turn out, uprise, rise | examples=I get up at 7 A.M. every day; They rose early

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "arise" in the given context, let's analyze the sentence and the provided candidate senses.

The sentence is: "He believed colon cancer might also arise from multiple 'hits 'on cancer suppressor genes, because it often seems to develop in stages."

Here, "arise" is used in the context of colon cancer developing or originating from certain genetic conditions.

Let's examine the candidate senses:

1. The first sense is "come into existence; take on form or shape" with synonyms like "originate, rise, develop, uprise, spring up, grow." The example given is "A new religious movement originated in that country; a love that sprang up from friendship." This sense fits the context as it talks about something coming into existence or developing.

2. The second sense is "originate or come into being" with the example "a question arose." While this could potentially fit, it's more about a specific issue or question coming up rather than a condition or disease developing.

3. The third sense is "rise to one's feet" which doesn't fit the context as it relates to physical movement.

4. The fourth sense is "result or issue" with the example "A slight unpleasantness arose from this discussion." This could potentially fit as it implies something resulting from a particular cause or situation.

5. The fifth sense is "move upward" which is more about physical movement and doesn't directly relate to the development of a disease.

6. The sixth sense is "take part in a rebellion; renounce a former allegiance" which is unrelated to the context.

7. The seventh sense is "get up and out of bed" which is also unrelated to the context.

Given the context, the most suitable sense is the first one: "come into existence; take on form or shape." The sentence discusses the belief that colon cancer might develop or originate from multiple genetic "hits" on cancer suppressor genes. This aligns with the idea of something (in this case, colon cancer) coming into existence or developing.

Therefore, the best indexed sense for "arise" in this context is the first one.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
"I was convinced that what was true of retinoblastoma would be true for all cancers. "It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer. He believed colon cancer might also arise from multiple "hits "on <t>cancer</t> suppressor genes, because it often seems to develop in stages. It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: often
Target surface form: often
Context:
"I was convinced that what was true of retinoblastoma would be true for all cancers. "It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer. He believed colon cancer might also arise from multiple "hits "on cancer suppressor genes, because it <t>often</t> seems to develop in stages. It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring.

Candidate senses:
1. sense_key=often%4:02:00:: | definition=many times at short intervals | synonyms=frequently, oftentimes, oft, ofttimes | examples=we often met over a cup of coffee
2. sense_key=often%4:02:01:: | definition=frequently or in great quantities | synonyms=much, a great deal | examples=I don't drink much; I don't travel much
3. sense_key=often%4:02:02:: | definition=in many cases or instances

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "often" in the given context, let's analyze the provided information step by step.

1. **Context Analysis**: The passage discusses the development of colon cancer and how it seems to progress in stages, often being preceded by the development of polyps in the bowel. The use of "often" here indicates a frequency or commonality of occurrence regarding the development stages of colon cancer.

2. **Candidate Senses Analysis**:
   - **Sense 1**: "many times at short intervals" with synonyms like "frequently, oftentimes, oft, ofttimes" and an example "we often met over a cup of coffee". This sense implies a repetition or recurrence at short intervals.
   - **Sense 2**: "frequently or in great quantities" with synonyms "much, a great deal" and examples "I don't drink much; I don't travel much". This sense is more about the quantity or degree rather than frequency of events.
   - **Sense 3**: "in many cases or instances". This sense indicates a general or common occurrence without specifying the interval or quantity.

3. **Applying Context to Candidate Senses**:
   - The context suggests that colon cancer "often seems to develop in stages" and is "often preceded by the development of polyps." Here, "often" is used to indicate that this is a common or general pattern observed in many cases, rather than specifying that it happens at short intervals or in great quantities.
   - **Sense 1** could potentially apply if the context implied that the development or the preceding condition happens repeatedly at short intervals for the same subject, but the passage is more focused on the general pattern across different instances or cases.
   - **Sense 2** doesn't fit well as the context is not discussing the quantity or degree of something but rather the frequency or commonality of a pattern or condition.
   - **Sense 3** ("in many cases or instances") fits the context best because it indicates that in many observed cases, colon cancer develops in stages and is preceded by polyps, aligning with the general or common occurrence interpretation.

4. **Conclusion**: Based on the analysis, the best indexed sense for "often" in the given context is **Sense 3**, as it correctly captures the notion of "in many cases or instances."

Therefore, the response in the required JSON format is: {"sense_index": 3}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: seem
Target surface form: seems
Context:
"I was convinced that what was true of retinoblastoma would be true for all cancers. "It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer. He believed colon cancer might also arise from multiple "hits "on cancer suppressor genes, because it often <t>seems</t> to develop in stages. It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring.

Candidate senses:
1. sense_key=seem%2:39:00:: | definition=give a certain impression or have a certain outward aspect | synonyms=look, appear | examples=She seems to be sleeping; This appears to be a very difficult problem
2. sense_key=seem%2:39:01:: | definition=seem to be true, probable, or apparent | synonyms=appear | examples=It seems that he is very gifted; It appears that the weather in California is very bad
3. sense_key=seem%2:42:00:: | definition=appear to exist | examples=There seems no reason to go ahead with the project now
4. sense_key=seem%2:39:02:: | definition=appear to one's own mind or opinion | examples=I seem to be misunderstood by everyone; I can't seem to learn these Chinese characters

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "seems" in the given context, let's analyze the sentence and the provided candidate senses.

The sentence is: "He believed colon cancer might also arise from multiple 'hits 'on cancer suppressor genes, because it often seems to develop in stages."

1. The first sense is defined as "give a certain impression or have a certain outward aspect" with synonyms "look, appear". The example given is "She seems to be sleeping; This appears to be a very difficult problem". This sense fits the context because "seems to develop in stages" implies that based on observation or evidence, colon cancer appears to progress in stages.

2. The second sense is "seem to be true, probable, or apparent" with the synonym "appear". Examples include "It seems that he is very gifted; It appears that the weather in California is very bad". This sense typically involves a clause following "it seems/appears that", which is not the structure used in the given sentence.

3. The third sense is "appear to exist" with the example "There seems no reason to go ahead with the project now". This sense is used in a specific construction ("There seems...") that doesn't match the sentence structure in question.

4. The fourth sense is "appear to one's own mind or opinion" with examples "I seem to be misunderstood by everyone; I can't seem to learn these Chinese characters". This involves a more subjective or personal perception, often with the subject being the speaker.

Given the context, "seems to develop in stages" best aligns with the first sense because it describes an observation or impression based on evidence (the development of polyps and their progression). The structure and usage fit the definition of giving a certain impression or having a certain outward aspect.

Therefore, the best indexed sense for "seems" in the given context is the first sense.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: develop
Target surface form: develop
Context:
"I was convinced that what was true of retinoblastoma would be true for all cancers. "It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer. He believed colon cancer might also arise from multiple "hits "on cancer suppressor genes, because it often seems to <t>develop</t> in stages. It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring.

Candidate senses:
1. sense_key=develop%2:36:01:: | definition=make something new, such as a product or a mental or artistic creation | examples=Her company developed a new kind of building material that withstands all kinds of weather; They developed a new technique
2. sense_key=develop%2:36:00:: | definition=work out | synonyms=evolve, germinate | examples=We have developed a new theory of evolution
3. sense_key=develop%2:30:06:: | definition=gain through experience | synonyms=acquire, evolve | examples=I acquired a strong aversion to television; Children must develop a sense of right and wrong
4. sense_key=develop%2:29:00:: | definition=come to have or undergo a change of (physical features and attributes) | synonyms=grow, produce, get, acquire | examples=He grew a beard; The patient developed abdominal pains
5. sense_key=develop%2:42:00:: | definition=come into existence; take on form or shape | synonyms=originate, arise, rise, uprise, spring up, grow | examples=A new religious movement originated in that country; a love that sprang up from friendship
6. sense_key=develop%2:30:04:: | definition=change the use of and make available or usable | synonyms=build up | examples=develop land; The country developed its natural resources
7. sense_key=develop%2:32:00:: | definition=elaborate, as of theories and hypotheses | synonyms=explicate, formulate | examples=Could you develop the ideas in your thesis
8. sense_key=develop%2:31:00:: | definition=create by training and teaching | synonyms=train, prepare, educate | examples=The old master is training world-class violinists; we develop the leaders for the future
9. sense_key=develop%2:30:05:: | definition=be gradually disclosed or unfolded; become manifest | examples=The plot developed slowly
10. sense_key=develop%2:30:00:: | definition=grow, progress, unfold, or evolve through a process of evolution, natural growth, differentiation, or a conducive environment | examples=A flower developed on the branch; The country developed into a mighty superpower
11. sense_key=develop%2:30:09:: | definition=become technologically advanced | synonyms=modernize, modernise | examples=Many countries in Asia are now developing at a very fast pace; Viet Nam is modernizing rapidly
12. sense_key=develop%2:30:01:: | definition=cause to grow and differentiate in ways conforming to its natural development | synonyms=make grow | examples=The perfect climate here develops the grain; He developed a new kind of apple
13. sense_key=develop%2:36:09:: | definition=generate gradually | examples=We must develop more potential customers; develop a market for the new mobile phone
14. sense_key=develop%2:30:10:: | definition=grow emotionally or mature | synonyms=grow | examples=The child developed beautifully in her new kindergarten; When he spent a summer at camp, the boy grew noticeably and no longer showed some of his old adolescent behavior
15. sense_key=develop%2:39:00:: | definition=make visible by means of chemical solutions | examples=Please develop this roll of film for me
16. sense_key=develop%2:35:04:: | definition=superimpose a three-dimensional surface on a plane without stretching, in geometry
17. sense_key=develop%2:33:03:: | definition=move one's pieces into strategically more advantageous positions | examples=Spassky developed quickly
18. sense_key=develop%2:33:02:: | definition=move into a strategically more advantageous position | examples=develop the rook
19. sense_key=develop%2:30:13:: | definition=elaborate by the unfolding of a musical idea and by the working out of the rhythmic and harmonic changes in the theme | examples=develop the melody and change the key
20. sense_key=develop%2:30:03:: | definition=happen | synonyms=break, recrudesce | examples=Report the news as it develops; These political movements recrudesce from time to time
21. sense_key=develop%2:30:12:: | definition=expand in the form of a series | examples=Develop the function in the following form

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "develop" in the given context, let's analyze the sentence and the provided candidate senses.

The sentence is: "He believed colon cancer might also arise from multiple 'hits 'on cancer suppressor genes, because it often seems to develop in stages."

The context is discussing the progression or evolution of colon cancer. The word "develop" here is related to the idea of something progressing or evolving over time, particularly in stages.

Let's examine the relevant candidate senses:

- Sense 1 refers to making something new, which doesn't directly fit the context of cancer progression.
- Sense 2 (work out) and Sense 3 (gain through experience) are plausible but not directly related to the context of physical or biological progression.
- Sense 4 (come to have or undergo a change of physical features and attributes) and Sense 10 (grow, progress, unfold, or evolve through a process of evolution, natural growth, differentiation, or a conducive environment) both relate to the idea of something changing or progressing over time, which fits the context.
- Sense 5 (come into existence; take on form or shape) is also a possibility but is more about the initial formation rather than progression in stages.
- Sense 9 (be gradually disclosed or unfolded; become manifest) and Sense 20 (happen) could fit in a broad sense but are not as directly related to the biological or physical progression as some other senses.

Given the context that colon cancer "often seems to develop in stages" and is "preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages," the most relevant sense is related to the progression or evolution of a condition over time.

Sense 10 directly corresponds to this idea, as it involves growing, progressing, unfolding, or evolving through a process, which aligns with the context of colon cancer developing in stages.

Therefore, the best indexed sense for "develop" in this context is Sense 10.

{"sense_index": 10}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: stage
Target surface form: stages
Context:
"I was convinced that what was true of retinoblastoma would be true for all cancers. "It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer. He believed colon cancer might also arise from multiple "hits "on cancer suppressor genes, because it often seems to develop in <t>stages</t>. It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring.

Candidate senses:
1. sense_key=stage%1:28:00:: | definition=any distinct time period in a sequence of events | synonyms=phase | examples=we are in a transitional stage in which many former ideas must be revised or rejected
2. sense_key=stage%1:26:00:: | definition=a specific identifiable position in a continuum or series or especially in a process | synonyms=degree, level, point | examples=a remarkable degree of frankness; at what stage are the social sciences?
3. sense_key=stage%1:06:00:: | definition=a large platform on which people can stand and can be seen by an audience | examples=he clambered up onto the stage and got the actors to help him into the box
4. sense_key=stage%1:10:00:: | definition=the theater as a profession (usually `the stage') | examples=an early movie simply showed a long kiss by two actors of the contemporary stage
5. sense_key=stage%1:06:01:: | definition=a large coach-and-four formerly used to carry passengers and mail on regular routes between towns | synonyms=stagecoach | examples=we went out of town together by stage about ten or twelve miles
6. sense_key=stage%1:04:00:: | definition=a section or portion of a journey or course | synonyms=leg | examples=then we embarked on the second stage of our Caribbean cruise
7. sense_key=stage%1:15:00:: | definition=any scene regarded as a setting for exhibiting or doing something; --Shakespeare | examples=All the world's a stage; it set the stage for peaceful negotiations
8. sense_key=stage%1:06:02:: | definition=a small platform on a microscope where the specimen is mounted for examination | synonyms=microscope stage

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: often
Target surface form: often
Context:
It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer. He believed colon cancer might also arise from multiple "hits "on cancer suppressor genes, because it often seems to develop in stages. It <t>often</t> is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring. Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage.

Candidate senses:
1. sense_key=often%4:02:00:: | definition=many times at short intervals | synonyms=frequently, oftentimes, oft, ofttimes | examples=we often met over a cup of coffee
2. sense_key=often%4:02:01:: | definition=frequently or in great quantities | synonyms=much, a great deal | examples=I don't drink much; I don't travel much
3. sense_key=often%4:02:02:: | definition=in many cases or instances

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "often" in the given context, let's analyze the provided information step by step.

1. **Context Analysis**: The passage discusses Dr. Vogelstein's research on colon cancer, suggesting that it develops in stages and is often preceded by the development of polyps in the bowel. The target sentence is: "It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages..."

2. **Understanding the Target Word**: The word "often" is used to describe the frequency of an event related to colon cancer, specifically that it is preceded by the development of polyps.

3. **Examining Candidate Senses**:
   - **1. often%4:02:00::**: This sense is defined as "many times at short intervals" with synonyms like "frequently, oftentimes, oft, ofttimes." An example given is "we often met over a cup of coffee." This implies a recurring event happening within a relatively short timeframe.
   - **2. often%4:02:01::**: Defined as "frequently or in great quantities" with synonyms "much, a great deal." Examples include "I don't drink much; I don't travel much." This sense seems to relate more to quantity rather than frequency of events.
   - **3. often%4:02:02::**: This is defined as "in many cases or instances." This sense focuses on the general occurrence or prevalence of something across various instances.

4. **Applying Context to Candidate Senses**:
   - The context suggests that colon cancer is frequently preceded by the development of polyps. This is a statement about the general tendency or common instances where colon cancer develops.
   - Sense 1 implies a frequency over short intervals, which isn't directly relevant to the general statement about colon cancer and polyps.
   - Sense 2 relates to quantity, which doesn't fit the context of discussing the frequency of an event (colon cancer being preceded by polyps).
   - Sense 3, "in many cases or instances," fits well as it describes a general tendency or common occurrence, aligning with the statement that colon cancer is often preceded by polyps.

5. **Conclusion**: Based on the context and the definitions provided, the best sense for "often" is the one that describes a general or common occurrence.

Therefore, the best indexed sense is: {"sense_index": 3}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: precede
Target surface form: preceded
Context:
It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer. He believed colon cancer might also arise from multiple "hits "on cancer suppressor genes, because it often seems to develop in stages. It often is <t>preceded</t> by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring. Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage.

Candidate senses:
1. sense_key=precede%2:42:00:: | definition=be earlier in time; go back further | synonyms=predate, forego, forgo, antecede, antedate | examples=Stone tools precede bronze tools
2. sense_key=precede%2:42:01:: | definition=come before | synonyms=predate | examples=Most English adjectives precede the noun they modify
3. sense_key=precede%2:41:00:: | definition=be the predecessor of | synonyms=come before | examples=Bill preceded John in the long line of Susan's husbands
4. sense_key=precede%2:38:00:: | definition=move ahead (of others) in time or space | synonyms=lead
5. sense_key=precede%2:32:03:: | definition=furnish with a preface or introduction | synonyms=preface, premise, introduce | examples=She always precedes her lectures with a joke; He prefaced his lecture with a critical remark about the institution

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "preceded" in the given context, let's analyze the provided information step by step.

1. **Context Analysis**: The passage discusses Dr. Vogelstein's research on colon cancer and mentions that it "often is preceded by the development of polyps in the bowel." This indicates a temporal or causal relationship where one event (development of polyps) happens before another (colon cancer).

2. **Understanding the Target Word**: The word "preceded" is used in the context of one condition (development of polyps) occurring before another (colon cancer).

3. **Examining Candidate Senses**:
   - **1. be earlier in time; go back further**: This sense is about something happening before something else in time, often with a connotation of going back further in history or time. Example: "Stone tools precede bronze tools."
   - **2. come before**: This is a more general sense indicating that something comes before something else, often in a sequence or order. Example: "Most English adjectives precede the noun they modify."
   - **3. be the predecessor of**: This implies a more direct succession or replacement, often used in contexts like a job or a position. Example: "Bill preceded John in the long line of Susan's husbands."
   - **4. move ahead (of others) in time or space**: This sense is about leading or being ahead of others, either in time or spatially. Example is not directly relevant but implies a sense of progression or movement.
   - **5. furnish with a preface or introduction**: This involves adding an introductory section or comment before the main content. Example: "She always precedes her lectures with a joke."

4. **Choosing the Best Sense**:
   - The context indicates that the development of colon cancer is often preceded by the development of polyps, suggesting a temporal relationship.
   - Sense 1 ("be earlier in time; go back further") fits this context as it describes a situation where one event (development of polyps) is earlier in time than another (colon cancer).
   - Sense 2 ("come before") is also a potential fit because it generally indicates that something comes before something else, which applies to the development of polyps before colon cancer.

5. **Decision**:
   - Between senses 1 and 2, both could potentially fit. However, sense 1 specifically mentions being "earlier in time; go back further," which aligns well with the temporal progression described (polyps developing before colon cancer). Sense 2 is more general and can apply to various sequences, not just temporal ones.
   - The context emphasizes a temporal relationship rather than a general sequence or order, making sense 1 a more appropriate choice.

6. **Conclusion**: The best indexed sense for "preceded" in the given context is **1**.

The final answer is: {"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: development
Target surface form: development
Context:
It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer. He believed colon cancer might also arise from multiple "hits "on cancer suppressor genes, because it often seems to develop in stages. It often is preceded by the <t>development</t> of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring. Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage.

Candidate senses:
1. sense_key=development%1:04:01:: | definition=act of improving by expanding or enlarging or refining | examples=he congratulated them on their development of a plan to meet the emergency; they funded research and development
2. sense_key=development%1:22:02:: | definition=a process in which something passes by degrees to a different stage (especially a more advanced or mature stage) | synonyms=evolution | examples=the development of his ideas took many years; the evolution of Greek civilization
3. sense_key=development%1:22:01:: | definition=(biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level | synonyms=growth, growing, maturation, ontogeny, ontogenesis | examples=he proposed an indicator of osseous development in children
4. sense_key=development%1:11:01:: | definition=a recent event that has some relevance for the present situation | examples=recent developments in Iraq; what a revolting development!
5. sense_key=development%1:04:02:: | definition=the act of making some area of land or water more profitable or productive or useful | synonyms=exploitation | examples=the development of Alaskan resources; the exploitation of copper deposits
6. sense_key=development%1:15:00:: | definition=a district that has been developed to serve some purpose | examples=such land is practical for small park developments
7. sense_key=development%1:26:00:: | definition=a state in which things are improving; the result of developing (as in the early part of a game of chess) | examples=after he saw the latest development he changed his mind and became a supporter; in chess your should take care of your development before moving your queen
8. sense_key=development%1:22:00:: | definition=processing a photosensitive material in order to make an image visible | synonyms=developing | examples=the development and printing of his pictures took only two hours
9. sense_key=development%1:10:00:: | definition=(music) the section of a composition or movement (especially in sonata form) where the major musical themes are developed and elaborated

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best indexed sense for the target word "development" in the given context, let's analyze the context and the provided candidate senses.

The context discusses the progression of colon cancer, mentioning that it often seems to develop in stages and is preceded by the development of polyps in the bowel, which can become increasingly malignant. This context suggests a biological process involving the growth or progression of a condition (colon cancer and polyps) within an organism.

Let's examine the candidate senses:

1. **Act of improving by expanding or enlarging or refining**: This doesn't directly relate to the biological progression described.
2. **A process in which something passes by degrees to a different stage**: This is a broad definition that could apply, as it mentions progression through stages, similar to the "evolution" synonym provided.
3. **(Biology) the process of an individual organism growing organically**: This directly relates to the context, as it involves the biological unfolding of events in an organism, such as the growth or development of polyps.
4. **A recent event that has some relevance for the present situation**: This doesn't fit the context, as "development" here refers to a process rather than an event.
5. **The act of making some area of land or water more profitable or productive or useful**: This is unrelated to the biological context.
6. **A district that has been developed to serve some purpose**: This refers to a geographical or spatial development, not relevant here.
7. **A state in which things are improving; the result of developing**: While this involves improvement or progression, it's more abstract and not specifically biological.
8. **Processing a photosensitive material in order to make an image visible**: This is unrelated to the context, as it pertains to photography.
9. **(Music) the section of a composition or movement where the major musical themes are developed and elaborated**: This is specific to music and not relevant.

Given the context and the definitions, the most appropriate sense is **3. (Biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level**. This matches the discussion of the development of polyps in the bowel and their potential to become malignant, indicating a biological process.

Therefore, the best indexed sense for "development" in this context is sense index 3.

{"sense_index": 3}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: polyp
Target surface form: polyps
Context:
It was an audacious claim. But in Baltimore, Dr. Vogelstein, a young molecular biologist at Johns Hopkins Medical School, believed Dr. Knudson was right, and set out to repeat the Cavenee experiment in cells from other cancers. His was one of two research teams in 1984 to report dual chromosome losses for a rare childhood cancer of the kidney called Wilm's tumor. Dr. Vogelstein next turned his attention colon cancer, the second biggest cancer killer in the U.S. after lung cancer. He believed colon cancer might also arise from multiple "hits "on cancer suppressor genes, because it often seems to develop in stages. It often is preceded by the development of <t>polyps</t> in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring. Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage.

Candidate senses:
1. sense_key=polyp%1:26:00:: | definition=a small vascular growth on the surface of a mucous membrane | synonyms=polypus
2. sense_key=polyp%1:05:00:: | definition=one of two forms that coelenterates take (e.g. a hydra or coral): usually sedentary with a hollow cylindrical body usually with a ring of tentacles around the mouth | examples=in some species of coelenterate, polyps are a phase in the life cycle that alternates with a medusoid phase

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the correct sense of the word "polyps" in the given context, let's analyze the information provided.

1. The context is about cancer research, specifically focusing on colon cancer.
2. It mentions that colon cancer often seems to develop in stages and is preceded by the development of polyps in the bowel.
3. The development of polyps is associated with becoming increasingly malignant in identifiable stages.

Given this context, we need to consider the two candidate senses provided for "polyp":

1. A small vascular growth on the surface of a mucous membrane.
2. One of two forms that coelenterates take, usually sedentary with a hollow cylindrical body, often with a ring of tentacles around the mouth.

The context clearly relates to medical or biological discussions about colon cancer and the bowel. The mention of "the bowel" and the process of becoming "increasingly malignant" strongly suggests that the polyps in question are related to health issues within the human body, specifically within the colon.

The first sense, "a small vascular growth on the surface of a mucous membrane," aligns with the medical context of colon cancer and the development of growths within the bowel. Colon polyps are known to be growths on the inner lining of the colon or rectum and can be precancerous.

The second sense refers to a form of coelenterate (like a hydra or coral), which is unrelated to the context of human cancer or bowel health.

Therefore, the most appropriate sense for "polyps" in this context is the first one, which describes a type of growth associated with mucous membranes, such as those found in the colon.

{"sense_index": 1}