[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: copy
Target surface form: copies
Context:
It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring. Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both <t>copies</t> of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop.

Candidate senses:
1. sense_key=copy%1:10:00:: | definition=a reproduction of a written record (e.g. of a legal or school record) | synonyms=transcript
2. sense_key=copy%1:06:00:: | definition=a thing made to be similar or identical to another thing | examples=she made a copy of the designer dress; the clone was a copy of its ancestor
3. sense_key=copy%1:10:01:: | definition=matter to be printed; exclusive of graphical materials | synonyms=written matter
4. sense_key=copy%1:10:02:: | definition=material suitable for a journalistic account | examples=catastrophes make good copy

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The context discusses genetic material and gene deletions, specifically referring to "copies of a certain gene" and "copies of a second gene." This usage aligns with the idea of multiple instances or versions of a gene, which is best captured by the sense of "a thing made to be similar or identical to another thing." Therefore, the most appropriate sense is:

**Sense 2: a thing made to be similar or identical to another thing (synonyms: clone).**

Thus, the best indexed sense is:

```json
{"sense_index": 2}
```


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: second
Target surface form: second
Context:
It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring. Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a <t>second</t> gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop.

Candidate senses:
1. sense_key=second%5:00:00:ordinal:00 | definition=coming next after the first in position in space or time or degree or magnitude | synonyms=2nd, 2d
2. sense_key=second%3:00:00:: | definition=a part or voice or instrument or orchestra section lower in pitch than or subordinate to the first | examples=second flute; the second violins

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The context describes a biological process where the loss of both copies of a "second gene" leads to the progression of benign polyps to malignancy. This usage clearly refers to the ordinal sense of "second," indicating the next gene in a sequence after the first gene. The other sense related to musical instruments does not fit the biological context.

Therefore, the best indexed sense is the ordinal sense.

{"sense_index": 1}

finish_reason: stop

role: assistant

currency: USD

source: unavailable


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: then
Target surface form: then
Context:
It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring. Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were <t>then</t> deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop.

Candidate senses:
1. sense_key=then%4:02:00:: | definition=subsequently or soon afterward (often used as sentence connectors) | synonyms=so, and so, and then | examples=then he left; go left first, then right
2. sense_key=then%4:02:02:: | definition=in that case or as a consequence | examples=if he didn't take it, then who did?; keep it then if you want to
3. sense_key=then%4:02:01:: | definition=at that time | examples=I was young then; prices were lower back then

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The word "then" in the sentence "If both copies of a second gene were <t>then</t> deleted, the polyps would progress to malignancy." is used to indicate a consequence or result of the preceding condition. This aligns with the definition "in that case or as a consequence." Therefore, the best indexed sense is the second sense listed.

The appropriate JSON response is:

```json
{"sense_index": 2}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: delete
Target surface form: deleted
Context:
It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring. Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then <t>deleted</t>, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop.

Candidate senses:
1. sense_key=delete%2:35:00:: | definition=remove or make invisible | synonyms=cancel | examples=Please delete my name from your list
2. sense_key=delete%2:32:00:: | definition=wipe out digitally or magnetically recorded information | synonyms=erase | examples=Who erased the files form my hard disk?
3. sense_key=delete%2:30:00:: | definition=cut or eliminate | synonyms=edit, blue-pencil | examples=she edited the juiciest scenes

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The context describes genetic deletions in polyps and malignant cells, specifically mentioning that "if both copies of a second gene were then **deleted**, the polyps would progress to malignancy." This usage refers to the removal or elimination of genetic material, aligning with the definition of "cut or eliminate" and the synonym "edit" (as in editing out parts of a text or sequence). Therefore, the best sense is:

```json
{"sense_index": 3}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: polyp
Target surface form: polyps
Context:
It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring. Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the <t>polyps</t> would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop.

Candidate senses:
1. sense_key=polyp%1:26:00:: | definition=a small vascular growth on the surface of a mucous membrane | synonyms=polypus
2. sense_key=polyp%1:05:00:: | definition=one of two forms that coelenterates take (e.g. a hydra or coral): usually sedentary with a hollow cylindrical body usually with a ring of tentacles around the mouth | examples=in some species of coelenterate, polyps are a phase in the life cycle that alternates with a medusoid phase

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The context describes "polyps" in the context of bowel development, genetic damage, and cancer progression. This clearly refers to the medical/colorectal sense of polyps as small growths on mucous membranes, not the biological sense of coelenterates. Therefore, the best indexed sense is the first one.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: malignancy
Target surface form: malignancy
Context:
It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring. Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to <t>malignancy</t>. It was clear that more than one gene had to be damaged for colon cancer to develop.

Candidate senses:
1. sense_key=malignancy%1:26:00:: | definition=(medicine) a malignant state; progressive and resistant to treatment and tending to cause death | synonyms=malignance
2. sense_key=malignancy%1:07:00:: | definition=quality of being disposed to evil; intense ill will | synonyms=malignity, malignance

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The context describes the progression of polyps to a state that is "progressive and resistant to treatment and tending to cause death," which aligns with the medical definition of malignancy. The synonyms "malignance" and the medical context further confirm this interpretation. Therefore, the best indexed sense is the medical one.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: clear
Target surface form: clear
Context:
Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was <t>clear</t> that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists.

Candidate senses:
1. sense_key=clear%3:00:00:: | definition=readily apparent to the mind | examples=a clear and present danger; a clear explanation
2. sense_key=clear%5:00:00:clearheaded:00 | definition=free from confusion or doubt | examples=a complex problem requiring a clear head; not clear about what is expected of us
3. sense_key=clear%5:00:00:unobstructed:00 | definition=affording free passage or view | synonyms=open | examples=a clear view; a clear path to victory
4. sense_key=clear%3:00:02:: | definition=allowing light to pass through | examples=clear water; clear plastic bags
5. sense_key=clear%5:00:02:free:00 | definition=free from contact or proximity or connection | examples=we were clear of the danger; the ship was clear of the reef
6. sense_key=clear%5:00:00:untroubled:00 | definition=characterized by freedom from troubling thoughts (especially guilt) | examples=a clear conscience; regarded her questioner with clear untroubled eyes
7. sense_key=clear%5:00:01:pure:02 | definition=(of sound or color) free from anything that dulls or dims | synonyms=clean, light, unclouded | examples=efforts to obtain a clean bass in orchestral recordings; clear laughter like a waterfall
8. sense_key=clear%5:00:00:unencumbered:00 | definition=(especially of a title) free from any encumbrance or limitation that presents a question of fact or law | synonyms=unmortgaged | examples=I have clear title to this property
9. sense_key=clear%5:00:00:distinct:00 | definition=clear and distinct to the senses; easily perceptible | synonyms=clean-cut, clear-cut | examples=as clear as a whistle; clear footprints in the snow
10. sense_key=clear%3:00:04:: | definition=accurately stated or described | synonyms=well-defined | examples=a set of well-defined values
11. sense_key=clear%3:00:03:: | definition=free from clouds or mist or haze | examples=on a clear day
12. sense_key=clear%5:00:00:unqualified:02 | definition=free of restrictions or qualifications | synonyms=clean | examples=a clean bill of health; a clear winner
13. sense_key=clear%5:00:00:perfect:00 | definition=free from flaw or blemish or impurity | examples=a clear perfect diamond; the clear complexion of a healthy young woman
14. sense_key=clear%5:00:00:net:00 | definition=clear of charges or deductions | examples=a clear profit
15. sense_key=clear%5:00:00:legible:00 | definition=easily deciphered | synonyms=decipherable, readable
16. sense_key=clear%5:00:00:innocent:00 | definition=freed from any question of guilt | synonyms=absolved, cleared, exculpated, exonerated, vindicated | examples=is absolved from all blame; was now clear of the charge of cowardice
17. sense_key=clear%5:00:00:discerning:00 | definition=characterized by ease and quickness in perceiving | synonyms=percipient | examples=clear mind; a percipient author

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The sentence "It was **clear** that more than one gene had to be damaged for colon cancer to develop." uses "clear" to mean "readily apparent to the mind" or "free from confusion or doubt." The context indicates that the conclusion about the necessity of multiple gene damages is evident and understood, fitting the sense of something being obvious or easily perceived.

Among the candidate senses, the one that best captures this meaning is:

- **sense_key=clear%3:00:00::** – definition: readily apparent to the mind; examples: a clear and present danger; a clear explanation.

This sense aligns with the idea that the relationship between gene damage and cancer development is evident and understood.

Therefore, the best indexed sense is:

```json
{"sense_index": 3}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: damage
Target surface form: damaged
Context:
Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be <t>damaged</t> for colon cancer to develop. Their report galvanized other molecular biologists.

Candidate senses:
1. sense_key=damage%2:30:00:: | definition=inflict damage upon | examples=The snow damaged the roof; She damaged the car when she hit the tree
2. sense_key=damage%2:30:01:: | definition=suffer or be susceptible to damage | examples=These fine china cups damage easily

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best sense for "damaged" in the given context, we analyze the surrounding text:

- The sentence discusses "genetic damage" and "signs of genetic damage."
- The phrase "more than one gene had to be <t>damaged</t> for colon cancer to develop" implies that the genes are affected or harmed in some way.
- The context is about genetic alterations leading to cancer, not about physical objects being harmed by external forces.

Given this, the appropriate sense is one where "damage" refers to the act of harming or altering something, specifically in a genetic context. This aligns with:

**sense_key=damage%2:30:00:: | definition=inflict damage upon | examples=The snow damaged the roof; She damaged the car when she hit the tree**

This sense captures the idea of genes being harmed or altered, which fits the context of genetic damage leading to cancer development.

Therefore, the best indexed sense is:

```json
{"sense_index": 1}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: develop
Target surface form: develop
Context:
Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to <t>develop</t>. Their report galvanized other molecular biologists.

Candidate senses:
1. sense_key=develop%2:36:01:: | definition=make something new, such as a product or a mental or artistic creation | examples=Her company developed a new kind of building material that withstands all kinds of weather; They developed a new technique
2. sense_key=develop%2:36:00:: | definition=work out | synonyms=evolve, germinate | examples=We have developed a new theory of evolution
3. sense_key=develop%2:30:06:: | definition=gain through experience | synonyms=acquire, evolve | examples=I acquired a strong aversion to television; Children must develop a sense of right and wrong
4. sense_key=develop%2:29:00:: | definition=come to have or undergo a change of (physical features and attributes) | synonyms=grow, produce, get, acquire | examples=He grew a beard; The patient developed abdominal pains
5. sense_key=develop%2:42:00:: | definition=come into existence; take on form or shape | synonyms=originate, arise, rise, uprise, spring up, grow | examples=A new religious movement originated in that country; a love that sprang up from friendship
6. sense_key=develop%2:30:04:: | definition=change the use of and make available or usable | synonyms=build up | examples=develop land; The country developed its natural resources
7. sense_key=develop%2:32:00:: | definition=elaborate, as of theories and hypotheses | synonyms=explicate, formulate | examples=Could you develop the ideas in your thesis
8. sense_key=develop%2:31:00:: | definition=create by training and teaching | synonyms=train, prepare, educate | examples=The old master is training world-class violinists; we develop the leaders for the future
9. sense_key=develop%2:30:05:: | definition=be gradually disclosed or unfolded; become manifest | examples=The plot developed slowly
10. sense_key=develop%2:30:00:: | definition=grow, progress, unfold, or evolve through a process of evolution, natural growth, differentiation, or a conducive environment | examples=A flower developed on the branch; The country developed into a mighty superpower
11. sense_key=develop%2:30:09:: | definition=become technologically advanced | synonyms=modernize, modernise | examples=Many countries in Asia are now developing at a very fast pace; Viet Nam is modernizing rapidly
12. sense_key=develop%2:30:01:: | definition=cause to grow and differentiate in ways conforming to its natural development | synonyms=make grow | examples=The perfect climate here develops the grain; He developed a new kind of apple
13. sense_key=develop%2:36:09:: | definition=generate gradually | examples=We must develop more potential customers; develop a market for the new mobile phone
14. sense_key=develop%2:30:10:: | definition=grow emotionally or mature | synonyms=grow | examples=The child developed beautifully in her new kindergarten; When he spent a summer at camp, the boy grew noticeably and no longer showed some of his old adolescent behavior
15. sense_key=develop%2:39:00:: | definition=make visible by means of chemical solutions | examples=Please develop this roll of film for me
16. sense_key=develop%2:35:04:: | definition=superimpose a three-dimensional surface on a plane without stretching, in geometry
17. sense_key=develop%2:33:03:: | definition=move one's pieces into strategically more advantageous positions | examples=Spassky developed quickly
18. sense_key=develop%2:33:02:: | definition=move into a strategically more advantageous position | examples=develop the rook
19. sense_key=develop%2:30:13:: | definition=elaborate by the unfolding of a musical idea and by the working out of the rhythmic and harmonic changes in the theme | examples=develop the melody and change the key
20. sense_key=develop%2:30:03:: | definition=happen | synonyms=break, recrudesce | examples=Report the news as it develops; These political movements recrudesce from time to time
21. sense_key=develop%2:30:12:: | definition=expand in the form of a series | examples=Develop the function in the following form

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The sentence discusses the process by which colon cancer emerges through genetic changes in polyps and malignant cells. The phrase "a coherent picture of cancer **development** emerged" refers to the process of cancer coming into being through genetic alterations. This aligns with the sense of "develop" meaning **to come into existence; to undergo a change of physical features and attributes**. The context of genetic damage leading to the formation of cancer best fits this sense.

Therefore, the best indexed sense is:

```json
{"sense_index": 4}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: report
Target surface form: report
Context:
They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their <t>report</t> galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City.

Candidate senses:
1. sense_key=report%1:10:03:: | definition=a written document describing the findings of some individual or group | synonyms=study, written report | examples=this accords with the recent study by Hill and Dale
2. sense_key=report%1:10:01:: | definition=the act of informing by verbal report | synonyms=account | examples=he heard reports that they were causing trouble; by all accounts they were a happy couple
3. sense_key=report%1:10:00:: | definition=a short account of the news | synonyms=news report, story, account, write up | examples=the report of his speech; the story was on the 11 o'clock news
4. sense_key=report%1:11:00:: | definition=a sharp explosive sound (especially the sound of a gun firing) | examples=they heard a violent report followed by silence
5. sense_key=report%1:10:04:: | definition=a written evaluation of a student's scholarship and deportment | synonyms=report card | examples=his father signed his report card
6. sense_key=report%1:10:02:: | definition=an essay (especially one written as an assignment) | synonyms=composition, paper, theme | examples=he got an A on his composition
7. sense_key=report%1:09:00:: | definition=the general estimation that the public has for a person | synonyms=reputation | examples=he acquired a reputation as an actor before he started writing; he was a person of bad report

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The context describes a scientific study or paper that provided crucial evidence for understanding cancer development, leading to other molecular biologists being motivated by its findings. This aligns with the sense of a "written document describing the findings of some individual or group," which is a study or written report. Therefore, the best indexed sense is:

```json
{"sense_index": 1}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: galvanize
Target surface form: galvanized
Context:
They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report <t>galvanized</t> other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City.

Candidate senses:
1. sense_key=galvanize%2:37:00:: | definition=to stimulate to action | synonyms=startle, galvanise | examples=..startled him awake; galvanized into action
2. sense_key=galvanize%2:35:00:: | definition=cover with zinc | synonyms=galvanise | examples=galvanize steel
3. sense_key=galvanize%2:29:02:: | definition=stimulate (muscles) by administering a shock | synonyms=galvanise

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The context describes how a scientific report "galvanized" other molecular biologists, meaning it stimulated them to action. This aligns with the definition "to stimulate to action" and the synonym "galvanise" used in the examples "galvanized into action." The other senses (covering with zinc or stimulating muscles) do not fit the context. Therefore, the best indexed sense is the first one.

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: other
Target surface form: other
Context:
They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized <t>other</t> molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City.

Candidate senses:
1. sense_key=other%3:00:00:: | definition=not the same one or ones already mentioned or implied; - the White Queen | examples=today isn't any other day; the construction of highways and other public works
2. sense_key=other%5:00:00:past:00 | definition=recently past | examples=the other evening
3. sense_key=other%5:00:02:past:00 | definition=belonging to the distant past | synonyms=early, former | examples=the early inhabitants of Europe; former generations
4. sense_key=other%5:00:00:strange:00 | definition=very unusual; different in character or quality from the normal or expected; - Lance Morrow | examples=a strange, other dimension...where his powers seemed to fail

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best sense for "other" in the given context, let's analyze the sentence:

"They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized **other** molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City."

### Contextual Analysis:
- The word "other" is used to refer to **additional molecular biologists** who were similarly affected or inspired by the report.
- The phrase "galvanized other molecular biologists" implies that the report influenced **more than the ones already mentioned** (presumably the researchers who conducted the study).

### Sense Evaluation:
1. **Sense 1**: "not the same one or ones already mentioned or implied; - the White Queen"
   - This sense fits well because "other" is referring to **additional individuals** (molecular biologists) who were not part of the initial group mentioned.
   - Examples like "today isn't any other day" and "the construction of highways and other public works" align with this usage.

2. **Sense 2**: "recently past"
   - This sense is about time and does not fit the context, as "other" is not referring to a time period.

3. **Sense 3**: "belonging to the distant past"
   - This sense also pertains to time and is irrelevant here, as the context is about contemporary scientists.

4. **Sense 4**: "very unusual; different in character or quality from the normal or expected; - Lance Morrow"
   - This sense suggests a quality or characteristic, which does not match the context where "other" is used to denote **additional entities**.

### Conclusion:
The best-fitting sense is **Sense 1**, which describes "other" as referring to additional individuals not already mentioned. Therefore, the correct indexed sense is:

```json
{"sense_index": 1}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: confirming
Target surface form: confirming
Context:
Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the <t>confirming</t> evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy.

Candidate senses:
1. sense_key=confirming%3:00:02:: | definition=indicating existence or presence of a suspected condition or pathogen | synonyms=positive | examples=a positive pregnancy test
2. sense_key=confirming%5:00:00:supportive:00 | definition=serving to support or corroborate | synonyms=collateral, confirmative, confirmatory, corroborative, corroboratory, substantiating | examples=collateral evidence

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The context describes evidence that "confirms" the critical role of gene losses in colon cancer development, aligning with the idea of supporting or corroborating a hypothesis. The synonyms like "confirmative," "confirmatory," and "corroborative" further support this interpretation. Therefore, the best sense is the one defined as "serving to support or corroborate."

The appropriate sense index is 2.

```json
{"sense_index": 2}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: evidence
Target surface form: evidence
Context:
Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming <t>evidence</t> we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy.

Candidate senses:
1. sense_key=evidence%1:09:00:: | definition=your basis for belief or disbelief; knowledge on which to base belief | synonyms=grounds | examples=the evidence that smoking causes lung cancer is very compelling
2. sense_key=evidence%1:10:01:: | definition=an indication that makes something evident | examples=his trembling was evidence of his fear
3. sense_key=evidence%1:10:00:: | definition=(law) all the means by which any alleged matter of fact whose truth is investigated at judicial trial is established or disproved

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The sentence "It was the confirming <t>evidence</t> we all needed that gene losses were critical to the development of a common tumor" uses "evidence" to refer to the supporting information or data that confirms a hypothesis or belief. This aligns with the definition of "evidence" as "your basis for belief or disbelief; knowledge on which to base belief," which is captured by the first candidate sense. The context is about scientific confirmation of a biological mechanism, not a legal proceeding or a direct observable sign of a state.

Therefore, the best indexed sense is:

```json
{"sense_index": 1}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: need
Target surface form: needed
Context:
Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all <t>needed</t> that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy.

Candidate senses:
1. sense_key=need%2:42:00:: | definition=require as useful, just, or proper | synonyms=necessitate, ask, postulate, require, take, involve | examples=It takes nerve to do what she did; success usually requires hard work
2. sense_key=need%2:34:00:: | definition=have need of | synonyms=want, require | examples=This piano wants the attention of a competent tuner
3. sense_key=need%2:34:01:: | definition=have or feel a need for | examples=always needing friends and money

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The sentence "It was the confirming evidence we all <t>needed</t> that gene losses were critical to the development of a common tumor" uses "needed" to express a requirement or necessity for the evidence to be considered confirming. This aligns with the sense of "require as useful, just, or proper," which is captured by the definition "require as useful, just, or proper" and its synonyms such as "require" and "necessitate." Therefore, the best indexed sense is the one defined as "require as useful, just, or proper."

The corresponding sense index in the provided list is 1.

Thus, the answer is:

```json
{"sense_index": 1}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: loss
Target surface form: losses
Context:
Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene <t>losses</t> were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy.

Candidate senses:
1. sense_key=loss%1:21:01:: | definition=something that is lost | examples=the car was a total loss; loss of livestock left the rancher bankrupt
2. sense_key=loss%1:22:00:: | definition=gradual decline in amount or activity | examples=weight loss; a serious loss of business
3. sense_key=loss%1:04:00:: | definition=the act of losing someone or something | examples=everyone expected him to win so his loss was a shock
4. sense_key=loss%1:07:00:: | definition=the disadvantage that results from losing something | synonyms=deprivation | examples=his loss of credibility led to his resignation; losing him is no great deprivation
5. sense_key=loss%1:11:01:: | definition=the experience of losing a loved one | examples=he sympathized on the loss of their grandfather
6. sense_key=loss%1:21:00:: | definition=the amount by which the cost of a business exceeds its revenue | synonyms=red ink, red | examples=the company operated at a loss last year; the company operated in the red last year
7. sense_key=loss%1:11:00:: | definition=military personnel lost by death or capture | synonyms=personnel casualty
8. sense_key=loss%1:11:02:: | definition=euphemistic expressions for death | synonyms=passing, departure, exit, expiration, going, release | examples=thousands mourned his passing

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The context discusses gene "losses" in relation to the development of colon cancer, emphasizing that the loss of certain genes is critical for the progression to malignancy. This aligns with the sense of "loss" referring to the act or process of losing something, specifically the loss of gene function leading to a biological change. Therefore, the best sense is:

```json
{"sense_index": 3}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: critical
Target surface form: critical
Context:
Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were <t>critical</t> to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy.

Candidate senses:
1. sense_key=critical%3:00:01:: | definition=marked by a tendency to find and call attention to errors and flaws | examples=a critical attitude
2. sense_key=critical%3:00:04:: | definition=at or of a point at which a property or phenomenon suffers an abrupt change especially having enough mass to sustain a chain reaction | examples=a critical temperature of water is 100 degrees C--its boiling point at standard atmospheric pressure; critical mass
3. sense_key=critical%3:00:02:: | definition=characterized by careful evaluation and judgment | examples=a critical reading; a critical dissertation
4. sense_key=critical%5:00:00:indispensable:00 | definition=urgently needed; absolutely necessary | synonyms=vital | examples=a critical element of the plan; critical medical supplies
5. sense_key=critical%5:00:00:crucial:00 | definition=forming or having the nature of a turning point or crisis | synonyms=decisive | examples=a critical point in the campaign; the critical test
6. sense_key=critical%3:00:03:: | definition=being in or verging on a state of crisis or emergency | examples=a critical shortage of food; a critical illness
7. sense_key=critical%3:01:00:: | definition=of or involving or characteristic of critics or criticism | examples=critical acclaim

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The sentence discusses the necessity of gene loss for the development of colon cancer, emphasizing that such gene losses are "critical" to this process. The context implies that these gene losses are **absolutely necessary** for the cancer to develop, aligning with the sense of "critical" meaning "urgently needed; absolutely necessary." This matches the definition and examples provided for sense_key `critical%5:00:00:indispensable:00`, which includes the synonym "vital" and examples like "a critical element of the plan; critical medical supplies."

Therefore, the best indexed sense is:

```json
{"sense_index": 3}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: development
Target surface form: development
Context:
Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the <t>development</t> of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy.

Candidate senses:
1. sense_key=development%1:04:01:: | definition=act of improving by expanding or enlarging or refining | examples=he congratulated them on their development of a plan to meet the emergency; they funded research and development
2. sense_key=development%1:22:02:: | definition=a process in which something passes by degrees to a different stage (especially a more advanced or mature stage) | synonyms=evolution | examples=the development of his ideas took many years; the evolution of Greek civilization
3. sense_key=development%1:22:01:: | definition=(biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level | synonyms=growth, growing, maturation, ontogeny, ontogenesis | examples=he proposed an indicator of osseous development in children
4. sense_key=development%1:11:01:: | definition=a recent event that has some relevance for the present situation | examples=recent developments in Iraq; what a revolting development!
5. sense_key=development%1:04:02:: | definition=the act of making some area of land or water more profitable or productive or useful | synonyms=exploitation | examples=the development of Alaskan resources; the exploitation of copper deposits
6. sense_key=development%1:15:00:: | definition=a district that has been developed to serve some purpose | examples=such land is practical for small park developments
7. sense_key=development%1:26:00:: | definition=a state in which things are improving; the result of developing (as in the early part of a game of chess) | examples=after he saw the latest development he changed his mind and became a supporter; in chess your should take care of your development before moving your queen
8. sense_key=development%1:22:00:: | definition=processing a photosensitive material in order to make an image visible | synonyms=developing | examples=the development and printing of his pictures took only two hours
9. sense_key=development%1:10:00:: | definition=(music) the section of a composition or movement (especially in sonata form) where the major musical themes are developed and elaborated

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The context discusses the biological progression of benign polyps to malignancy in colon cancer, emphasizing the role of gene damage in this process. This aligns with the sense of "development" that refers to a biological unfolding from a simple to a more complex stage, specifically the growth and transformation of cells. Therefore, the best sense is:

```json
{"sense_index": 3}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: common
Target surface form: common
Context:
Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a <t>common</t> tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy.

Candidate senses:
1. sense_key=common%3:00:02:: | definition=belonging to or participated in by a community as a whole; public | examples=for the common good; common lands are set aside for use by all members of a community
2. sense_key=common%3:00:01:: | definition=having no special distinction or quality; widely known or commonly encountered; average or ordinary or usual | examples=the common man; a common sailor
3. sense_key=common%5:00:00:shared:00 | definition=common to or shared by two or more parties | synonyms=mutual | examples=a common friend; the mutual interests of management and labor
4. sense_key=common%5:00:00:familiar:02 | definition=commonly encountered | synonyms=usual | examples=a common (or familiar) complaint; the usual greeting
5. sense_key=common%5:00:00:informal:02 | definition=being or characteristic of or appropriate to everyday language | synonyms=vernacular, vulgar | examples=common parlance; a vernacular term
6. sense_key=common%5:00:00:lowborn:00 | definition=of or associated with the great masses of people | synonyms=plebeian, vulgar, unwashed | examples=the common people in those days suffered greatly; behavior that branded him as common
7. sense_key=common%5:00:00:inferior:02 | definition=of low or inferior quality or value; - Shakespeare | synonyms=coarse | examples=of what coarse metal ye are molded; produced...the common cloths used by the poorer population
8. sense_key=common%5:00:00:unrefined:01 | definition=lacking refinement or cultivation or taste | synonyms=coarse, rough-cut, uncouth, vulgar | examples=he had coarse manners but a first-rate mind; behavior that branded him as common
9. sense_key=common%5:00:00:ordinary:00 | definition=to be expected; standard | examples=common decency

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The sentence context discusses the development of colon cancer and mentions that the polyps would progress to malignancy, emphasizing that gene losses were critical to the development of a **common tumor**. The term "common" here refers to a tumor that is shared or experienced by multiple individuals or cases, indicating a widespread occurrence across different patients. This aligns with the sense of something being **common to or shared by two or more parties**.

Therefore, the best indexed sense is:

```json
{"sense_index": 3}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: say
Target surface form: says
Context:
Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "<t>says</t> Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy.

Candidate senses:
1. sense_key=say%2:32:00:: | definition=express in words | synonyms=state, tell | examples=He said that he wanted to marry her; tell me what is bothering you
2. sense_key=say%2:32:01:: | definition=report or maintain | synonyms=allege, aver | examples=He alleged that he was the victim of a crime; He said it was too late to intervene in the war
3. sense_key=say%2:32:03:: | definition=express a supposition | synonyms=suppose | examples=Let us say that he did not tell the truth; Let's say you had a lot of money--what would you do?
4. sense_key=say%2:42:00:: | definition=have or contain a certain wording or form | synonyms=read | examples=The passage reads as follows; What does the law say?
5. sense_key=say%2:32:04:: | definition=give instructions to or direct somebody to do something with authority | synonyms=order, tell, enjoin | examples=I said to him to go home; She ordered him to do the shopping
6. sense_key=say%2:32:02:: | definition=speak, pronounce, or utter in a certain way | synonyms=pronounce, articulate, enounce, sound out, enunciate | examples=She pronounces French words in a funny way; I cannot say `zip wire'
7. sense_key=say%2:32:07:: | definition=communicate or express nonverbally | examples=What does this painting say?; Did his face say anything about how he felt?
8. sense_key=say%2:32:15:: | definition=utter aloud | examples=She said `Hello' to everyone in the office
9. sense_key=say%2:32:13:: | definition=state as one's opinion or judgement; declare | examples=I say let's forget this whole business
10. sense_key=say%2:32:08:: | definition=recite or repeat a fixed text | examples=Say grace; She said her `Hail Mary'
11. sense_key=say%2:32:09:: | definition=indicate | examples=The clock says noon

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The sentence "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "<t>says</t> Ray White at Howard Hughes Medical Institute in Salt Lake City." uses "says" to quote Ray White's statement about the significance of gene losses in tumor development. This aligns with the sense of reporting or maintaining a claim, i.e., "report or maintain." Therefore, the best indexed sense is:

```json
{"sense_index": 2}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: yet
Target surface form: yet
Context:
If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had <t>yet</t> to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy. They focused on chromosome 17.

Candidate senses:
1. sense_key=yet%4:02:02:: | definition=up to the present time | examples=I have yet to see the results; details are yet to be worked out
2. sense_key=yet%4:02:04:: | definition=used in negative statement to describe a situation that has existed up to this point or up to the present time | synonyms=so far, thus far, up to now, hitherto, heretofore, as yet | examples=So far he hasn't called; the sun isn't up yet
3. sense_key=yet%4:02:03:: | definition=to a greater degree or extent; used with comparisons | synonyms=even, still | examples=looked sick and felt even worse; an even (or still) more interesting problem
4. sense_key=yet%4:02:00:: | definition=within an indefinite time or at an unspecified future time | synonyms=in time | examples=he longed for the flowers that were yet to show themselves; sooner or later you will have to face the facts
5. sense_key=yet%4:02:05:: | definition=used after a superlative | synonyms=so far | examples=this is the best so far; the largest drug bust yet
6. sense_key=yet%4:02:06:: | definition=despite anything to the contrary (usually following a concession) | synonyms=however, nevertheless, withal, still, all the same, even so | examples=although I'm a little afraid, however I'd like to try it; while we disliked each other, nevertheless we agreed

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The sentence "But Dr. Vogelstein had <t>yet</t> to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy." uses "yet" to indicate that up to this point, the identity of the gene had not been determined. This aligns with the definition "used in negative statement to describe a situation that has existed up to this point or up to the present time," which is captured by sense_key yet%4:02:04::. Therefore, the best indexed sense is:

```json
{"sense_index": 2}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: nail
Target surface form: nail
Context:
If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to <t>nail</t> the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy. They focused on chromosome 17.

Candidate senses:
1. sense_key=nail%2:35:00:: | definition=attach something somewhere by means of nails | examples=nail the board onto the wall
2. sense_key=nail%2:35:01:: | definition=take into custody | synonyms=collar, apprehend, arrest, pick up, nab, cop | examples=the police nabbed the suspected criminals
3. sense_key=nail%2:35:02:: | definition=hit hard | synonyms=smash, boom, blast | examples=He smashed a 3-run homer
4. sense_key=nail%2:41:01:: | definition=succeed in obtaining a position | synonyms=nail down, peg | examples=He nailed down a spot at Harvard
5. sense_key=nail%2:41:00:: | definition=succeed at easily | synonyms=breeze through, ace, pass with flying colors, sweep through, sail through | examples=She sailed through her exams; You will pass with flying colors
6. sense_key=nail%2:40:00:: | definition=locate exactly | synonyms=pinpoint | examples=can you pinpoint the position of the enemy?; The chemists could not nail the identity of the chromosome
7. sense_key=nail%2:33:00:: | definition=complete a pass | synonyms=complete

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The context describes Dr. Vogelstein's effort to determine the specific gene responsible for transforming a colon cell into full-blown malignancy. The phrase "nail the identity of the gene" implies a precise determination or pinpointing of the gene's role, akin to securing or locating something exactly. Among the candidate senses, sense_key=nail%2:40:00:: ("locate exactly"; synonyms: pinpoint) best matches this usage, as it involves identifying or determining something with precision.

Therefore, the best indexed sense is:

```json
{"sense_index": 6}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: identity
Target surface form: identity
Context:
If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the <t>identity</t> of the gene that, if damaged, flipped a colon cell into full-blown malignancy. They focused on chromosome 17.

Candidate senses:
1. sense_key=identity%1:07:00:: | definition=the distinct personality of an individual regarded as a persisting entity | synonyms=personal identity, individuality | examples=you can lose your identity when you join the army
2. sense_key=identity%1:09:00:: | definition=the individual characteristics by which a thing or person is recognized or known | examples=geneticists only recently discovered the identity of the gene that causes it; it was too dark to determine his identity
3. sense_key=identity%1:24:01:: | definition=an operator that leaves unchanged the element on which it operates | synonyms=identity element, identity operator | examples=the identity under numerical multiplication is 1
4. sense_key=identity%1:07:02:: | definition=exact sameness | synonyms=identicalness, indistinguishability | examples=they shared an identity of interests

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The context discusses determining "the <t>identity</t> of the gene" that, when damaged, leads to colon cancer. This usage aligns with the sense of "identity" meaning "the individual characteristics by which a thing or person is recognized or known," specifically in the context of identifying a specific gene. Therefore, the best indexed sense is the second one.

```json
{"sense_index": 2}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: damage
Target surface form: damaged
Context:
If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if <t>damaged</t>, flipped a colon cell into full-blown malignancy. They focused on chromosome 17.

Candidate senses:
1. sense_key=damage%2:30:00:: | definition=inflict damage upon | examples=The snow damaged the roof; She damaged the car when she hit the tree
2. sense_key=damage%2:30:01:: | definition=suffer or be susceptible to damage | examples=These fine china cups damage easily

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best sense for "damaged" in the given context, we analyze the sentence:

*"But Dr. Vogelstein had yet to nail the identity of the gene that, if <t>damaged</t>, flipped a colon cell into full-blown malignancy."*

**Contextual Analysis:**
- The sentence discusses genetic mutations leading to cancer.
- "Damaged" refers to a gene being altered or mutated, which is a biological process rather than physical harm to an object.
- The phrase "if <t>damaged</t>" implies that the gene's integrity is compromised, affecting its function.

**Sense Comparison:**
1. **Sense 1: "inflict damage upon"**
   - Definition: To cause harm or injury to something.
   - Example: "The snow damaged the roof."
   - This sense implies an external action causing harm, which doesn't fit the genetic context where the gene itself is being altered.

2. **Sense 2: "suffer or be susceptible to damage"**
   - Definition: To experience or be prone to harm or alteration.
   - Example: "These fine china cups damage easily."
   - This sense aligns with the idea of a gene being altered or mutated, making it susceptible to loss of function, which directly relates to the context of gene loss leading to malignancy.

**Conclusion:**
The context of a gene being "damaged" in a biological sense, where the gene's integrity is compromised, matches **Sense 2** ("suffer or be susceptible to damage"). Therefore, the best indexed sense is:

```json
{"sense_index": 2}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: flip
Target surface form: flipped
Context:
If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, <t>flipped</t> a colon cell into full-blown malignancy. They focused on chromosome 17.

Candidate senses:
1. sense_key=flip%2:38:00:: | definition=lightly throw to see which side comes up | synonyms=toss | examples=I don't know what to do--I may as well flip a coin!
2. sense_key=flip%2:35:01:: | definition=cause to go on or to be engaged or set in operation | synonyms=throw, switch | examples=switch on the light; throw the lever
3. sense_key=flip%2:39:10:: | definition=look through a book or other written material | synonyms=flick, thumb, riffle, leaf, riff | examples=He thumbed through the report; She leafed through the volume
4. sense_key=flip%2:38:02:: | definition=toss with a sharp movement so as to cause to turn over in the air | synonyms=twitch
5. sense_key=flip%2:38:01:: | definition=cause to move with a flick | synonyms=flick | examples=he flicked his Bic
6. sense_key=flip%2:35:00:: | definition=throw or toss with a light motion | synonyms=toss, sky, pitch | examples=flip me the beachball; toss me newspaper
7. sense_key=flip%2:35:05:: | definition=move with a flick or light motion
8. sense_key=flip%2:35:03:: | definition=turn upside down, or throw so as to reverse | synonyms=flip over, turn over | examples=flip over the pork chop; turn over the pancakes
9. sense_key=flip%2:31:00:: | definition=react in an excited, delighted, or surprised way | synonyms=flip out | examples=he flipped when he heard that he was accepted into Princeton University
10. sense_key=flip%2:30:13:: | definition=go mad, go crazy | synonyms=flip out | examples=He flipped when he heard that he was being laid off
11. sense_key=flip%2:30:00:: | definition=reverse (a direction, attitude, or course of action) | synonyms=interchange, tack, switch, alternate, flip-flop

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The sentence "But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, <t>flipped</t> a colon cell into full-blown malignancy." uses "flipped" to describe a transformation or reversal of a cell's state from benign to malignant due to gene damage. This aligns with the sense of causing a change or reversal in state, which is captured by:

**sense_key=flip%2:35:03::** definition=turn upside down, or throw so as to reverse | synonyms=flip over, turn over | examples=flip over the pork chop; turn over the pancakes

Thus, the best indexed sense is:

```json
{"sense_index": 8}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: colon
Target surface form: colon
Context:
If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a <t>colon</t> cell into full-blown malignancy. They focused on chromosome 17.

Candidate senses:
1. sense_key=colon%1:08:00:: | definition=the part of the large intestine between the cecum and the rectum; it extracts moisture from food residues before they are excreted
2. sense_key=colon%1:23:01:: | definition=the basic unit of money in El Salvador; equal to 100 centavos | synonyms=El Salvadoran colon
3. sense_key=colon%1:23:00:: | definition=the basic unit of money in Costa Rica; equal to 100 centimos | synonyms=Costa Rican colon
4. sense_key=colon%1:15:00:: | definition=a port city at the Caribbean entrance to the Panama Canal | synonyms=Aspinwall
5. sense_key=colon%1:10:00:: | definition=a punctuation mark (:) used after a word introducing a series or an example or an explanation (or after the salutation of a business letter)

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The context discusses gene damage leading to the development of colon cancer, specifically focusing on the colon as a part of the human anatomy involved in digestion. This clearly refers to the anatomical sense of "colon" rather than any monetary or geographical meanings. Therefore, the best indexed sense is the one describing the anatomical part of the large intestine.

The appropriate sense key is `colon%1:08:00::`, which corresponds to:

> "the part of the large intestine between the cecum and the rectum; it extracts moisture from food residues before they are excreted"

Thus, the correct sense index is 1.

```json
{"sense_index": 1}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cell
Context:
If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon <t>cell</t> into full-blown malignancy. They focused on chromosome 17.

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The context discusses gene knockouts and the development of malignancy in colon cancer, specifically mentioning a "colon <t>cell</t>." This clearly refers to a biological cell within a colon, not a compartment, electric device, political unit, mobile phone, monastery room, or prison. Therefore, the most appropriate sense is the biological definition of a cell.

The best indexed sense is:

```json
{"sense_index": 2}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: full-blown
Target surface form: full-blown
Context:
If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into <t>full-blown</t> malignancy. They focused on chromosome 17.

Candidate senses:
1. sense_key=full-blown%5:00:00:mature:01 | definition=fully ripe; at the height of bloom | synonyms=matured | examples=a full-blown rose
2. sense_key=full-blown%5:00:00:complete:00 | definition=having or displaying all the characteristics necessary for completeness | examples=a full-blown financial crisis

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The context describes the progression of benign polyps to malignancy when multiple genes are damaged, and specifically mentions that the colon cell "flipped into <t>full-blown</t> malignancy." This usage emphasizes the complete and advanced stage of malignancy, indicating that the cancer has fully developed all necessary characteristics for being a full, mature malignancy. The synonym "complete" and the example "a full-blown financial crisis" both support the idea of something being entirely realized or fully developed, rather than merely mature or at the height of bloom. Therefore, the best sense is the one that conveys completeness and full development.

The appropriate sense is:

**sense_key=full-blown%5:00:00:complete:00 | definition=having or displaying all the characteristics necessary for completeness | examples=a full-blown financial crisis**

Thus, the best indexed sense is the second one.

```json
{"sense_index": 2}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: malignancy
Target surface form: malignancy
Context:
If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown <t>malignancy</t>. They focused on chromosome 17.

Candidate senses:
1. sense_key=malignancy%1:26:00:: | definition=(medicine) a malignant state; progressive and resistant to treatment and tending to cause death | synonyms=malignance
2. sense_key=malignancy%1:07:00:: | definition=quality of being disposed to evil; intense ill will | synonyms=malignity, malignance

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The context describes the progression of polyps to "malignancy" in the context of gene deletions and cancer development. This clearly refers to the medical definition of malignancy as a malignant state associated with cancer, rather than the moral sense of ill will. Therefore, the best indexed sense is the medical one.

The appropriate sense index for this medical definition is 1.

Thus, the answer is:

```json
{"sense_index": 1}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: month
Target surface form: months
Context:
It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy. They focused on chromosome 17. For <t>months</t> the Johns Hopkins researchers, using gene probes, experimentally crawled down the length of chromosome 17, looking for the smallest common bit of genetic material lost in all tumor cells. Such a piece of DNA would probably constitute a gene.

Candidate senses:
1. sense_key=month%1:28:01:: | definition=one of the twelve divisions of the calendar year | synonyms=calendar month | examples=he paid the bill last month
2. sense_key=month%1:28:00:: | definition=a time unit of approximately 30 days | examples=he was given a month to pay the bill

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The context describes a period of time during which researchers conducted experiments, specifically "for months the Johns Hopkins researchers...". This usage refers to an extended period of time, not a specific division of the calendar year. Therefore, the most appropriate sense is the one that denotes a time unit of approximately 30 days.

**Chosen sense:** a time unit of approximately 30 days.

**Corresponding sense key:** month%1:28:00::

**JSON response:** {"sense_index": 2}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: using
Context:
It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy. They focused on chromosome 17. For months the Johns Hopkins researchers, <t>using</t> gene probes, experimentally crawled down the length of chromosome 17, looking for the smallest common bit of genetic material lost in all tumor cells. Such a piece of DNA would probably constitute a gene.

Candidate senses:
1. sense_key=use%2:34:01:: | definition=put into service; make work or employ for a particular purpose or for its inherent or natural purpose | synonyms=utilize, utilise, apply, employ | examples=use your head!; we only use Spanish at home
2. sense_key=use%2:34:02:: | definition=take or consume (regularly or habitually) | synonyms=habituate | examples=She uses drugs rarely
3. sense_key=use%2:34:00:: | definition=use up, consume fully | synonyms=expend | examples=The legislature expended its time on school questions
4. sense_key=use%2:41:14:: | definition=seek or achieve an end by using to one's advantage | examples=She uses her influential friends to get jobs; The president's wife used her good connections
5. sense_key=use%2:41:04:: | definition=avail oneself to | synonyms=practice, apply | examples=apply a principle; practice a religion
6. sense_key=use%2:41:03:: | definition=habitually do something (use only in the past tense) | examples=She used to call her mother every week but now she calls only occasionally; I used to get sick when I ate in that dining hall

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
To determine the best sense for "using" in the given context, let's analyze the sentence:

"It was clear that more than one gene had to be damaged for colon cancer to develop. ... the Johns Hopkins researchers, **using** gene probes, experimentally crawled down the length of chromosome 17, looking for the smallest common bit of genetic material lost in all tumor cells."

**Contextual Analysis:**
- The phrase "using gene probes" indicates that the researchers are employing gene probes as a tool or method in their experimental process.
- The purpose is to "experimentally crawl down the length of chromosome 17," which suggests a systematic application of the probes to investigate the chromosome.

**Synonym and Example Matching:**
- **Sense 1:** "put into service; make work or employ for a particular purpose or for its inherent or natural purpose" with synonyms like "utilize," "apply," and "employ."
  - Example: "use your head!" or "we only use Spanish at home."
  - This aligns well with the context where gene probes are being employed as a tool for a specific scientific purpose.

- **Sense 2:** "take or consume (regularly or habitually)" with synonym "habituate."
  - Example: "She uses drugs rarely."
  - This does not fit the context, as the sentence is not about habitual consumption.

- **Sense 3:** "use up, consume fully" with synonym "expend."
  - Example: "The legislature expended its time on school questions."
  - This does not fit, as the context is about employing a tool, not depleting resources.

- **Sense 4:** "seek or achieve an end by using to one's advantage."
  - Example: "She uses her influential friends to get jobs."
  - This implies a strategic advantage, which is not the primary focus here.

- **Sense 5:** "avail oneself to" with synonyms "practice" and "apply."
  - Example: "apply a principle; practice a religion."
  - While "apply" is a close synonym, the context is more about employing a tool (gene probes) rather than applying a principle or practicing a religion.

- **Sense 6:** "habitually do something (use only in the past tense)."
  - Example: "She used to call her mother every week."
  - This does not fit, as the context is about a current experimental method, not a habitual past action.

**Conclusion:**
The context clearly indicates the employment of gene probes as a methodological tool in an experiment, which best matches **Sense 1**: "put into service; make work or employ for a particular purpose or for its inherent or natural purpose."

Therefore, the best indexed sense is:

```json
{"sense_index": 3}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: down
Target surface form: down
Context:
It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy. They focused on chromosome 17. For months the Johns Hopkins researchers, using gene probes, experimentally crawled <t>down</t> the length of chromosome 17, looking for the smallest common bit of genetic material lost in all tumor cells. Such a piece of DNA would probably constitute a gene.

Candidate senses:
1. sense_key=down%4:02:00:: | definition=spatially or metaphorically from a higher to a lower level or position | synonyms=downwards, downward, downwardly | examples=don't fall down; rode the lift up and skied down
2. sense_key=down%4:02:02:: | definition=away from a more central or a more northerly place | examples=was sent down to work at the regional office; worked down on the farm
3. sense_key=down%4:02:03:: | definition=paid in cash at time of purchase | examples=put ten dollars down on the necklace
4. sense_key=down%4:02:06:: | definition=from an earlier time | examples=the story was passed down from father to son
5. sense_key=down%4:02:05:: | definition=to a lower intensity | examples=he slowly phased down the light until the stage was completely black
6. sense_key=down%4:02:04:: | definition=in an inactive or inoperative state | examples=the factory went down during the strike; the computer went down again

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The context describes researchers "experimentally crawled down the length of chromosome 17," which implies moving along the chromosome from one end to the other, i.e., progressing along its length in a spatial or metaphorical direction from a higher to a lower position. This aligns with the definition of "down" as "spatially or metaphorically from a higher to a lower level or position." Therefore, the best sense is the first one.

The sense key for this is down%4:02:00::, but the instruction is to return only the sense index without the key. The sense index for this is 1.

Thus, the answer is:

{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: length
Target surface form: length
Context:
It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy. They focused on chromosome 17. For months the Johns Hopkins researchers, using gene probes, experimentally crawled down the <t>length</t> of chromosome 17, looking for the smallest common bit of genetic material lost in all tumor cells. Such a piece of DNA would probably constitute a gene.

Candidate senses:
1. sense_key=length%1:07:00:: | definition=the linear extent in space from one end to the other; the longest dimension of something that is fixed in place | examples=the length of the table was 5 feet
2. sense_key=length%1:07:01:: | definition=continuance in time | synonyms=duration | examples=the ceremony was of short duration; he complained about the length of time required
3. sense_key=length%1:07:02:: | definition=the property of being the extent of something from beginning to end | examples=the editor limited the length of my article to 500 words
4. sense_key=length%1:07:03:: | definition=size of the gap between two places | synonyms=distance | examples=the distance from New York to Chicago; he determined the length of the shortest line segment joining the two points
5. sense_key=length%1:06:00:: | definition=a section of something that is long and narrow | examples=a length of timber; a length of tubing

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
The context refers to "experimentally crawled down the <t>length</t> of chromosome 17," which implies moving along the linear extent of the chromosome. This aligns with the definition of "length" as the linear extent in space from one end to the other. Therefore, the best sense is:

```json
{"sense_index": 1}
```