[User]
Which numbered sense of "patient" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in <t>patients</t> with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Senses:
1. definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

reasoning_content:
1.  **Analyze the Request:** The user wants to identify which numbered sense of the word "patient" (<t>patients</t>) is used in the provided context. The output must be *only* the number.

2.  **Analyze the Context:**
    *   "The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight)." (Here, "patient" refers to the person receiving the treatment.)
    *   "...patients should take a corticosteroid and folic acid..." (Refers to the people receiving the treatment.)
    *   "...Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal..." (Refers to the people receiving the treatment.)
    *   "Alimta is not recommended for use in <t>patients</t> with moderate or severe kidney problems." (Refers to the people receiving the treatment.)

3.  **Analyze the Senses:**
    *   **Sense 1:** definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly. (This is the common, everyday definition of a person receiving care.)
    *   **Sense 2:** definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role. (This is a technical linguistic/semantic role definition, often used in NLP/syntax.)

4.  **Match Context to Sense:**
    *   The word "patients" in the context refers to *people* (individuals) who are receiving medical treatment (Alimta).
    *   This matches the definition of **Sense 1** ("a person who requires medical care").
    *   It does *not* match the technical linguistic definition of **Sense 2**.

5.  **Formulate the Output:** The correct sense is 1. (The instruction requires returning only the number.)


attempt_kind: initial

status: success

[User]
Which numbered sense of "moderate" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with <t>moderate</t> or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Senses:
1. definition=being within reasonable or average limits; not excessive or extreme | examples=moderate prices; a moderate income
2. definition=not extreme | synonyms=temperate | examples=a moderate penalty; temperate in his response to criticism
3. definition=marked by avoidance of extravagance or extremes | synonyms=restrained | examples=moderate in his demands; restrained in his response

finish_reason: stop

role: assistant

reasoning_content:
1.  **Analyze the request:** The user wants to identify which numbered sense of the word "moderate" is used in the provided context. The output must be *only* the number.

2.  **Analyze the context:** The relevant sentence is: "Alimta is not recommended for use in patients with <t>moderate</t> or severe kidney problems."

3.  **Determine the meaning of "moderate" in this context:** "Moderate kidney problems" refers to a level of kidney dysfunction that is significant enough to be a concern but not as severe as "severe kidney problems." It implies a level that is neither minimal/mild nor extreme/severe.

4.  **Evaluate the senses:**

    *   **Sense 1:** definition=being within reasonable or average limits; not excessive or extreme | examples=moderate prices; a moderate income.
        *   *Fit:* "Moderate kidney problems" fits the idea of being within a certain range or not being extreme (i.e., not severe).

    *   **Sense 2:** definition=not extreme | synonyms=temperate | examples=a moderate penalty; temperate in his response to criticism.
        *   *Fit:* This is a general definition of "not extreme." It is very close to Sense 1, but Sense 1 specifically links it to "reasonable or average limits," which is often how medical classifications (mild, moderate, severe) operate.

    *   **Sense 3:** definition=marked by avoidance of extravagance or extremes | synonyms=restrained | examples=moderate in his demands; restrained in his response.
        *   *Fit:* This sense relates to behavior or style (restraint, temperance). It does not apply to a medical condition (kidney problems).

5.  **Compare Sense 1 and Sense 2:**
    *   Sense 2 ("not extreme") is accurate.
    *   Sense 1 ("being within reasonable or average limits; not excessive or extreme") is the most precise fit for medical grading (mild, moderate, severe). When classifying a condition, "moderate" means it falls into a defined, non-extreme category.

6.  **Conclusion:** Sense 1 best captures the meaning of "moderate" when describing the severity of a medical condition.

7.  **Final Output Generation:** Return only the number 1.

currency: USD

source: unavailable


[User]
Which numbered sense of "severe" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or <t>severe</t> kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Senses:
1. definition=intensely or extremely bad or unpleasant in degree or quality | synonyms=terrible, wicked | examples=severe pain; a severe case of flu
2. definition=very strong or vigorous | synonyms=hard, knockout | examples=strong winds; a hard left to the chin
3. definition=severely simple | synonyms=austere, stark, stern | examples=a stark interior
4. definition=unsparing and uncompromising in discipline or judgment; - H.G.Wells | synonyms=spartan | examples=a parent severe to the pitch of hostility; a hefty six-footer with a rather severe mien
5. definition=causing fear or anxiety by threatening great harm | synonyms=dangerous, grave, grievous, serious, life-threatening | examples=a dangerous operation; a grave situation
6. definition=very bad in degree or extent | examples=a severe worldwide depression; the house suffered severe damage

reasoning_content:
1.  **Analyze the context:** The phrase is "Alimta is not recommended for use in patients with moderate or <t>severe</t> kidney problems."
2.  **Determine the meaning of "severe" in this context:** It refers to the *degree* or *extent* of the kidney problems (renal impairment). The problems are not just mild or moderate; they are at a high, critical level.
3.  **Examine the senses provided:**
    *   1. intensely or extremely bad or unpleasant in degree or quality (e.g., severe pain, severe flu). -> Fits the idea of high degree/badness.
    *   2. very strong or vigorous (e.g., strong winds). -> Does not fit kidney problems.
    *   3. severely simple (e.g., stark interior). -> Does not fit kidney problems.
    *   4. unsparing and uncompromising (e.g., severe mien). -> Does not fit kidney problems.
    *   5. causing fear or anxiety by threatening great harm (e.g., grave situation). -> This is related to the *consequence* (threat of harm), but the context is describing the *level* of the problem itself.
    *   6. very bad in degree or extent (e.g., severe worldwide depression, severe damage). -> Directly addresses the concept of high degree or extent of a negative condition (kidney problems).
4.  **Compare the best fits (1 and 6):**
    *   Sense 1: "intensely or extremely bad or unpleasant in degree or quality."
    *   Sense 6: "very bad in degree or extent."
    *   Both are very close. However, Sense 6 specifically uses the phrasing "in degree or extent" and provides examples related to damage/conditions (severe damage, severe depression), which aligns perfectly with describing the *level* of kidney problems. Sense 1 is slightly broader (including "unpleasant quality"), while Sense 6 is focused on the magnitude of the negative state.
5.  **Select the most precise match:** Sense 6 is the most accurate fit for describing the level of a medical condition (kidney problems).


[User]
Which numbered sense of "problem" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney <t>problems</t>. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Senses:
1. definition=a state of difficulty that needs to be resolved | synonyms=job | examples=she and her husband are having problems; it is always a job to contact him
2. definition=a question raised for consideration or solution | examples=our homework consisted of ten problems to solve
3. definition=a source of difficulty | synonyms=trouble | examples=one trouble after another delayed the job; what's the problem?

reasoning_content:
1.  **Analyze the context:** The phrase is "Alimta is not recommended for use in patients with moderate or severe kidney <t>problems</t>."
2.  **Determine the meaning of "problems" in this specific context:** The context refers to a medical condition (kidney issues) that makes the patient unsuitable for the drug. The "problems" are the underlying difficulties or issues with the kidney function.
3.  **Evaluate the senses:**
    *   **Sense 1:** definition=a state of difficulty that needs to be resolved | synonyms=job | examples=she and her husband are having problems; it is always a job to contact him. (This fits the idea of a difficulty/issue.)
    *   **Sense 2:** definition=a question raised for consideration or solution | examples=our homework consisted of ten problems to solve. (This is clearly incorrect; kidney issues are not questions.)
    *   **Sense 3:** definition=a source of difficulty | synonyms=trouble | examples=one trouble after another delayed the job; what's the problem?. (This also fits the idea of a source of difficulty/issue.)
4.  **Distinguish between Sense 1 and Sense 3:**
    *   Sense 1 focuses on the *state* of difficulty (e.g., "They are having problems").
    *   Sense 3 focuses on the *source* of difficulty (e.g., "The kidney problems are the source of difficulty").
5.  **Apply to the context:** "Kidney problems" refers to the existing, problematic condition of the kidneys. This condition *is* the source or manifestation of the difficulty.
6.  **Select the best fit:** Both 1 and 3 are plausible, but Sense 3 ("a source of difficulty") captures the nature of a medical condition (a source of trouble/difficulty) slightly better than Sense 1 ("a state of difficulty that needs to be resolved"), especially when referring to an organ's function. However, in common usage, "kidney problems" functions as a state of difficulty. Let's re-examine the examples.
    *   Sense 1 example: "she and her husband are having problems" (State of difficulty).
    *   Sense 3 example: "one trouble after another delayed the job" (Source/instance of difficulty).
    *   In the medical context, "kidney problems" refers to the *condition* (the state/source) that prevents treatment. Since the options are very close, let's look for the most encompassing definition. A medical condition is fundamentally a source of difficulty.

7.  **Final check:** If the kidneys have "problems," those problems are the *trouble* or *source of difficulty* that makes the patient unsuitable. Sense 3 is the most precise fit for a medical condition being cited as a reason for exclusion.

8.  **Conclusion:** Sense 3.


[User]
Which numbered sense of "more" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For <t>more</t> information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Senses:
1. definition=(comparative of `much' used with mass nouns) a quantifier meaning greater in size or amount or extent or degree | synonyms=more than | examples=more land; more support
2. definition=(comparative of `many' used with count nouns) quantifier meaning greater in number | examples=a hall with more seats; we have no more bananas

reasoning_content:
1.  **Analyze the request:** The user wants to identify which numbered sense of the word "more" is used in the provided context. The output must be only the number.

2.  **Analyze the context:** The phrase containing "more" is: "For <t>more</t> information, see the Summary of Product Characteristics (also part of the EPAR)."

3.  **Analyze the word "information":** "Information" is an uncountable (mass) noun.

4.  **Analyze the usage of "more":** "More information" means a greater amount or extent of information.

5.  **Evaluate Sense 1:**
    *   Definition: (comparative of `much' used with mass nouns) a quantifier meaning greater in size or amount or extent or degree.
    *   Examples: more land; more support.
    *   Match: "Information" is a mass noun, and "more information" means a greater amount/extent. This matches Sense 1.

6.  **Evaluate Sense 2:**
    *   Definition: (comparative of `many' used with count nouns) quantifier meaning greater in number.
    *   Examples: a hall with more seats; we have no more bananas.
    *   Match: "Information" is not a count noun. This does not match Sense 2.

7.  **Conclusion:** Sense 1 is the correct sense.

8.  **Format the output:** Return only the number.


[User]
Which numbered sense of "information" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more <t>information</t>, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Senses:
1. definition=a message received and understood | synonyms=info
2. definition=knowledge acquired through study or experience or instruction
3. definition=formal accusation of a crime
4. definition=a collection of facts from which conclusions may be drawn | synonyms=data | examples=statistical data
5. definition=(communication theory) a numerical measure of the uncertainty of an outcome | synonyms=selective information, entropy | examples=the signal contained thousands of bits of information

reasoning_content:
1.  **Analyze the request:** The user wants to identify which numbered sense of the word "information" (marked with `<t>information</t>`) is used in the provided context. The output must be *only* the number.

2.  **Analyze the context:** The relevant sentence is: "For more <t>information</t>, see the Summary of Product Characteristics (also part of the EPAR)."

3.  **Determine the meaning of "information" in this context:** The context is a medical/drug information leaflet. "For more information" means "for more details," "for more facts," or "for more knowledge/data about the drug." The reader is being directed to a source (Summary of Product Characteristics) to gain more knowledge or details about the drug's properties and usage.

4.  **Evaluate the senses provided:**

    *   **1. definition=a message received and understood | synonyms=info:** This relates to communication (a specific message). While the leaflet *is* a message, the phrase "For more information" here is a general request for *details* or *knowledge*, not necessarily a single, specific message being received at that moment.
    *   **2. definition=knowledge acquired through study or experience or instruction:** This fits well. The Summary of Product Characteristics is a document designed to provide the necessary knowledge/details about the drug. The reader is seeking knowledge.
    *   **3. definition=formal accusation of a crime:** Incorrect (legal context).
    *   **4. definition=a collection of facts from which conclusions may be drawn | synonyms=data | examples=statistical data:** This is also a very strong candidate. The Summary of Product Characteristics is a collection of facts (data) about the drug.
    *   **5. definition=(communication theory) a numerical measure of the uncertainty of an outcome | synonyms=selective information, entropy | examples=the signal contained thousands of bits of information:** Incorrect (highly technical, theoretical context).

5.  **Compare Senses 2 and 4:**
    *   Sense 4 (Data/Collection of facts) is very accurate. The document *is* a collection of facts.
    *   Sense 2 (Knowledge acquired through study/instruction) is also very accurate. The purpose of reading the document is to acquire knowledge.

6.  **Refine the choice based on common usage ("For more information"):** When used in a directive like "For more information, see X," the meaning is generally "For more details/facts/knowledge." In common English usage, this often leans toward the broader concept of *knowledge* or *details* (Sense 2), rather than strictly *raw data* (Sense 4), although the source material (EPAR) is certainly data.

7.  **Re-evaluating the provided definitions:**
    *   Sense 2: "knowledge acquired through study or experience or instruction." (The reader is instructed to look at the document to gain knowledge.)
    *   Sense 4: "a collection of facts from which conclusions may be drawn." (The document *is* this collection of facts.)

    Both are plausible. However, Sense 2 captures the *purpose* of the request ("For more..."), which is the acquisition of knowledge. Sense 4 describes the *nature* of the source material. Given the options, Sense 2 is the most encompassing fit for the phrase "For more information" in a general instructional context.

8.  **Final Selection:** Sense 2. (If Sense 4 were the only option, it would also be acceptable, but Sense 2 is a better fit for the communicative intent.)


[User]
Which numbered sense of "see" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Senses:
1. definition=perceive by sight or have the power to perceive by sight | examples=You have to be a good observer to see all the details; Can you see the bird in that tree?
2. definition=perceive (an idea or situation) mentally | synonyms=understand, realize, realise | examples=Now I see!; I just can't see your point
3. definition=perceive or be contemporaneous with | synonyms=witness, find | examples=We found Republicans winning the offices; You'll see a lot of cheating in this school
4. definition=imagine; conceive of; see in one's mind | synonyms=visualize, visualise, envision, project, fancy, figure | examples=I can't see him on horseback!; I can see what will happen
5. definition=deem to be | synonyms=consider, reckon, view, regard | examples=She views this quite differently from me; I consider her to be shallow
6. definition=get to know or become aware of, usually accidentally | synonyms=learn, hear, get word, get wind, pick up, find out | examples=I learned that she has two grown-up children; I see that you have been promoted
7. definition=see or watch | synonyms=watch, view, catch, take in | examples=view a show on television; This program will be seen all over the world
8. definition=come together | synonyms=meet, run into, encounter, run across, come across | examples=I'll probably see you at the meeting; How nice to see you again!
9. definition=find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, find out, ascertain, watch, learn | examples=I want to see whether she speaks French; See whether it works
10. definition=be careful or certain to do something; make certain of something | synonyms=check, insure, see to it, ensure, control, ascertain | examples=He verified that the valves were closed; See that the curtains are closed
11. definition=go to see for professional or business reasons | examples=You should see a lawyer; We had to see a psychiatrist
12. definition=go to see for a social visit | examples=I went to see my friend Mary the other day
13. definition=go to see a place, as for entertainment | synonyms=visit | examples=We went to see the Eiffel Tower in the morning
14. definition=take charge of or deal with | synonyms=attend, take care, look | examples=Could you see about lunch?; I must attend to this matter
15. definition=receive as a specified guest | examples=the doctor will see you now; The minister doesn't see anybody before noon
16. definition=date regularly; have a steady relationship with | synonyms=go steady, go out, date | examples=Did you know that she is seeing an older man?; He is dating his former wife again!
17. definition=see and understand, have a good eye | examples=The artist must first learn to see
18. definition=deliberate or decide | examples=See whether you can come tomorrow; let's see--which movie should we see tonight?
19. definition=observe as if with an eye | examples=The camera saw the burglary and recorded it
20. definition=observe, check out, and look over carefully or inspect | synonyms=examine | examples=The customs agent examined the baggage; I must see your passport before you can enter the country
21. definition=go or live through | synonyms=experience, go through | examples=We had many trials to go through; he saw action in Viet Nam
22. definition=accompany or escort | synonyms=escort | examples=I'll see you to the door
23. definition=match or meet | examples=I saw the bet of one of my fellow players
24. definition=make sense of; assign a meaning to | synonyms=interpret, construe | examples=What message do you see in this letter?; How do you interpret his behavior?

reasoning_content:
1.  **Analyze the context:** The phrase is "For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR)."
2.  **Determine the meaning of 'see' in this context:** The context is instructing the reader where to find additional information (the Summary of Product Characteristics). This means the reader needs to look at, consult, or refer to that document.
3.  **Examine the senses provided:** I need to find a sense that means 'look at', 'refer to', or 'consult'.

    *   1. perceive by sight (literal sight) - Possible, but usually too narrow for a reference instruction.
    *   2. perceive mentally (understand) - Incorrect.
    *   3. perceive or be contemporaneous with (witness) - Incorrect.
    *   4. imagine (visualize) - Incorrect.
    *   5. deem to be (consider) - Incorrect.
    *   6. get to know (learn, find out) - Possible, but usually used for acquiring knowledge, not directing attention to a document.
    *   7. see or watch (view) - Possible, but often implies active viewing (like a show).
    *   8. come together (meet) - Incorrect.
    *   9. find out, learn, or determine with certainty, usually by making an inquiry or other effort (check, find out) - This fits the idea of consulting a source to gain information.
    *   10. be careful or certain to do something (ensure) - Incorrect.
    *   11. go to see for professional or business reasons - Incorrect (implies visiting a person/place).
    *   12. go to see for a social visit - Incorrect.
    *   13. go to see a place (visit) - Incorrect.
    *   14. take charge of or deal with - Incorrect.
    *   15. receive as a specified guest - Incorrect.
    *   16. date regularly - Incorrect.
    *   17. see and understand, have a good eye - Incorrect.
    *   18. deliberate or decide - Incorrect.
    *   19. observe as if with an eye - Incorrect.
    *   20. observe, check out, and look over carefully or inspect (examine) - This is a very strong candidate, as consulting a document is a form of careful inspection/review.
    *   21. go or live through (experience) - Incorrect.
    *   22. accompany or escort - Incorrect.
    *   23. match or meet - Incorrect.
    *   24. make sense of; assign a meaning to (interpret) - Incorrect.

4.  **Compare the best candidates (9 and 20):**
    *   Sense 9: "I want to see whether she speaks French." (Focus on the outcome/determination).
    *   Sense 20: "I must see your passport before you can enter the country." (Focus on the action of inspection/review).

    In the context "see the Summary of Product Characteristics," the instruction is to *review* or *consult* the document. Both 9 and 20 capture the idea of looking at something to gain information. However, Sense 20 ("observe, check out, and look over carefully or inspect") is the most precise fit for the action of reading and reviewing a detailed document like a Summary of Product Characteristics. Sense 9 is more about the *goal* of the inquiry, while Sense 20 describes the *method* (inspection/review).

5.  **Final Selection:** Sense 20.


[User]
Which numbered sense of "product" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR). How does Alimta work?

Senses:
1. definition=commodities offered for sale | synonyms=merchandise, ware | examples=good business depends on having good merchandise; that store offers a variety of products
2. definition=an artifact that has been created by someone or some process | synonyms=production | examples=they improve their product every year; they export most of their agricultural production
3. definition=a quantity obtained by multiplication | synonyms=mathematical product | examples=the product of 2 and 3 is 6
4. definition=a chemical substance formed as a result of a chemical reaction | examples=a product of lime and nitric acid
5. definition=a consequence of someone's efforts or of a particular set of circumstances | examples=skill is the product of hours of practice; his reaction was the product of hunger and fatigue
6. definition=the set of elements common to two or more sets | synonyms=intersection, Cartesian product | examples=the set of red hats is the intersection of the set of hats and the set of red things

reasoning_content:
1.  **Analyze the context:** The text describes a medical treatment regimen involving Alimta, cisplatin, corticosteroids, folic acid, and vitamin B12. It discusses dosages, side effects, kidney problems, and treatment protocols. The final sentence mentions: "For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR)."

2.  **Analyze the target word:** The word is "Product" in the context of a medical drug (Alimta) and its associated documentation (EPAR - European Public Assessment Report).

3.  **Determine the meaning of "Product" in this specific context:** When referring to a drug or medical treatment in regulatory documentation (like an EPAR), "Product" refers to the specific item being administered or manufactured—the drug itself.

4.  **Evaluate the senses provided:**

    *   1. definition=commodities offered for sale | synonyms=merchandise, ware | examples=good business depends on having good merchandise; that store offers a variety of products. (This relates to commercial goods, but drugs are commodities.)
    *   2. definition=an artifact that has been created by someone or some process | synonyms=production | examples=they improve their product every year; they export most of their agricultural production. (This relates to something manufactured or created, which fits a drug.)
    *   3. definition=a quantity obtained by multiplication | synonyms=mathematical product | examples=the product of 2 and 3 is 6. (Incorrect - mathematical.)
    *   4. definition=a chemical substance formed as a result of a chemical reaction | examples=a product of lime and nitric acid. (Incorrect - refers to chemical synthesis, not the finished drug.)
    *   5. definition=a consequence of someone's efforts or of a particular set of circumstances | examples=skill is the product of hours of practice; his reaction was the product of hunger and fatigue. (Incorrect - abstract consequence.)
    *   6. definition=the set of elements common to two or more sets | synonyms=intersection, Cartesian product. (Incorrect - mathematical set theory.)

5.  **Compare the context meaning to the best fit sense:**
    *   The drug Alimta is a manufactured item (an artifact created by a process).
    *   Sense 2: "an artifact that has been created by someone or some process." This is the most accurate definition for a pharmaceutical drug in a regulatory context. While Sense 1 (commodities) is also technically true, Sense 2 captures the essence of the item being *produced* and *manufactured*, which is the core meaning when discussing drug characteristics in an EPAR.

6.  **Conclusion:** Sense 2 is the correct fit.


[User]
Which numbered sense of "part" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR). How does Alimta work?

Senses:
1. definition=something determined in relation to something that includes it | synonyms=portion, component part, component, constituent | examples=he wanted to feel a part of something bigger than himself; I read a portion of the manuscript
2. definition=something less than the whole of a human artifact | synonyms=portion | examples=the rear part of the house; glue the two parts together
3. definition=a portion of a natural object | synonyms=piece | examples=they analyzed the river into three parts; he needed a piece of granite
4. definition=that which concerns a person with regard to a particular role or situation | examples=it requires vigilance on our part; they resisted every effort on his part
5. definition=the extended spatial location of something | synonyms=region | examples=the farming regions of France; religions in all parts of the world
6. definition=the actions and activities assigned to or required or expected of a person or group | synonyms=function, office, role | examples=the function of a teacher; the government must do its part
7. definition=an actor's portrayal of someone in a play | synonyms=character, role, theatrical role, persona | examples=she played the part of Desdemona
8. definition=assets belonging to or due to or contributed by an individual person or group | synonyms=share, portion, percentage | examples=he wanted his share in cash
9. definition=one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division | examples=the written part of the exam; the finance section of the company
10. definition=a line of scalp that can be seen when sections of hair are combed in opposite directions | synonyms=parting | examples=his part was right in the middle
11. definition=the melody carried by a particular voice or instrument in polyphonic music | synonyms=voice | examples=he tried to sing the tenor part
12. definition=the part played by a person in bringing about a result | synonyms=contribution, share | examples=I am proud of my contribution in advancing the project; they all did their share of the work

reasoning_content:
1.  **Analyze the context:** The phrase is "Summary of Product Characteristics (also <t>part</t> of the EPAR)."
2.  **Identify the meaning of "part" in this context:** The Summary of Product Characteristics (SPC) is a specific document or section that is included within the European Public Assessment Report (EPAR). It is a component or division of the larger document (EPAR).
3.  **Examine the senses provided:** I need to find the sense that describes a component or division of a whole document/artifact.

    *   1. definition=something determined in relation to something that includes it | synonyms=portion, component part, component, constituent | examples=he wanted to feel a part of something bigger than himself; I read a portion of the manuscript (Focuses on being a component/constituent).
    *   2. definition=something less than the whole of a human artifact | synonyms=portion | examples=the rear part of the house; glue the two parts together (Focuses on physical pieces/sections of an object).
    *   3. definition=a portion of a natural object | synonyms=piece | examples=they analyzed the river into three parts; he needed a piece of granite (Focuses on natural objects).
    *   4. definition=that which concerns a person with regard to a particular role or situation | examples=it requires vigilance on our part; they resisted every effort on his part (Focuses on responsibility/involvement).
    *   5. definition=the extended spatial location of something | synonyms=region | examples=the farming regions of France; religions in all parts of the world (Focuses on geography).
    *   6. definition=the actions and activities assigned to or required or expected of a person or group | synonyms=function, office, role | examples=the function of a teacher; the government must do its part (Focuses on duty/role).
    *   7. definition=an actor's portrayal of someone in a play | synonyms=character, role, theatrical role, persona | examples=she played the part of Desdemona (Focuses on acting).
    *   8. definition=assets belonging to or due to or contributed by an individual person or group | synonyms=share, portion, percentage | examples=he wanted his share in cash (Focuses on ownership/entitlement).
    *   9. definition=one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division | examples=the written part of the exam; the finance section of the company (Focuses on structural divisions of a whole).
    *   10. definition=a line of scalp that can be seen when sections of hair are combed in opposite directions | synonyms=parting | examples=his part was right in the middle (Focuses on hair).
    *   11. definition=the melody carried by a particular voice or instrument in polyphonic music | synonyms=voice | examples=he tried to sing the tenor part (Focuses on music).
    *   12. definition=the part played by a person in bringing about a result | synonyms=contribution, share | examples=I am proud of my contribution in advancing the project; they all did their share of the work (Focuses on contribution/role).

4.  **Compare relevant senses (1, 2, 9):**
    *   The SPC is a *section* or *division* of the EPAR.
    *   Sense 1 (component part/constituent): Fits well, as it is a constituent element.
    *   Sense 2 (portion of a human artifact): Fits, but is slightly broader than the specific idea of a defined section.
    *   Sense 9 (one of the portions into which something is regarded as divided and which together constitute a whole): This is the most precise definition for a structural division of a document (like a chapter, section, or part).

5.  **Select the best fit:** Sense 9 perfectly captures the relationship between the SPC and the EPAR—they are distinct, defined sections that make up the whole document. Sense 1 is also plausible but Sense 9 is more specific to the concept of structural division.

6.  **Final check:** "Summary of Product Characteristics (also part of the EPAR)." SPC is a section/division of the EPAR. Sense 9 is correct.


[User]
Which numbered sense of "active" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. definition=exerting influence or producing a change or effect | examples=an active ingredient
7. definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. definition=(of e.g. volcanos) capable of erupting
13. definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

reasoning_content:
1.  **Analyze the context:** The sentence is: "The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine..."
2.  **Determine the meaning of "active" in this context:** The word "active" refers to the substance (pemetrexed) having a function or effect—it is the part of the medicine that actually does the killing (cytotoxic) or blocks the enzymes.
3.  **Examine the senses provided:** I need to find the sense that means "having a function" or "producing an effect," especially when referring to a component of a mixture or medicine.
4.  **Evaluate relevant senses:**
    *   Sense 6: definition=exerting influence or producing a change or effect | examples=an active ingredient.
5.  **Match the meaning:** The substance is the "active ingredient" (or active substance) because it is the part that exerts the therapeutic effect (cytotoxic medicine).
6.  **Select the corresponding number:** Sense 6.


[User]
Which numbered sense of "substance" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=the real physical matter of which a person or thing consists | examples=DNA is the substance of our genes
2. definition=the choicest or most essential or most vital part of some idea or experience | synonyms=kernel, core, center, centre, essence, gist | examples=the gist of the prosecutor's argument; the heart and soul of the Republican Party
3. definition=the idea that is intended | synonyms=meaning | examples=What is the meaning of this proverb?
4. definition=material of a particular kind or constitution | examples=the immune response recognizes invading substances
5. definition=considerable capital (wealth or income) | synonyms=means | examples=he is a man of means
6. definition=what a communication that is about something is about | synonyms=message, content, subject matter
7. definition=a particular kind or species of matter with uniform properties | examples=shigella is one of the most toxic substances known to man

reasoning_content:
1.  **Analyze the context:** The sentence is: "The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine..."
2.  **Identify the role of "substance":** Here, "substance" refers to the specific chemical component (pemetrexed) that is active and functions as a medicine.
3.  **Examine the senses provided:**
    *   1. the real physical matter of which a person or thing consists (e.g., DNA is the substance of our genes). (Focuses on composition/matter).
    *   2. the choicest or most essential or most vital part of some idea or experience (e.g., the gist of the argument). (Focuses on essence/core idea).
    *   3. the idea that is intended (e.g., meaning). (Focuses on intent/meaning).
    *   4. material of a particular kind or constitution (e.g., the immune response recognizes invading substances). (Focuses on material/type).
    *   5. considerable capital (wealth or income). (Focuses on money/wealth).
    *   6. what a communication that is about something is about (e.g., message, content). (Focuses on topic/content).
    *   7. a particular kind or species of matter with uniform properties (e.g., shigella is one of the most toxic substances known to man). (Focuses on chemical/physical type).
4.  **Match the context to the senses:**
    *   The context refers to "pemetrexed," which is a specific chemical compound (a cytotoxic medicine).
    *   Sense 7 defines "substance" as "a particular kind or species of matter with uniform properties." This perfectly describes a chemical compound like pemetrexed.
    *   Sense 1 is close (physical matter), but Sense 7 is more precise, emphasizing the *type* or *species* of matter (a chemical entity).
5.  **Conclusion:** Sense 7 is the most accurate fit.


[User]
Which numbered sense of "medicine" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

reasoning_content:
1.  **Analyze the request:** The user wants to identify which numbered sense of the word "medicine" (marked with `<t>medicine</t>`) is used in the provided context. The output must be only the number.

2.  **Analyze the context:**
    *   The context discusses "Alimta," "cisplatin," "anti-emetic medicine," "fluids," "pemetrexed," and "cytotoxic medicine."
    *   The specific phrase is: "The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells)..."
    *   The definition provided immediately after the word in parentheses is: "(a medicine that kills cells that are dividing, such as cancer cells)."

3.  **Analyze the senses:**
    *   **Sense 1:** "the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty." (Refers to a field of study/specialty, e.g., internal medicine.)
    *   **Sense 2:** "(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug." (Refers to a substance/drug.)
    *   **Sense 3:** "the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard." (Refers to the profession/practice.)
    *   **Sense 4:** "punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine." (Refers to punishment/idiom.)

4.  **Match the context to the senses:**
    *   In the context, "pemetrexed is a cytotoxic medicine." Pemetrexed is a chemical substance (a drug) used to kill cancer cells.
    *   This aligns perfectly with Sense 2: "something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug."

5.  **Conclusion:** The correct sense is 2.


[User]
Which numbered sense of "medicine" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

reasoning_content:
1.  **Analyze the request:** The user wants to identify which numbered sense of the word "medicine" (marked with `<t>medicine</t>`) is used in the provided context. The output must be only the number.

2.  **Examine the context:** The relevant phrase is: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells)..."

3.  **Analyze the specific usage:** In this sentence, "medicine" refers to a substance (pemetrexed) that has a specific biological action (cytotoxic, kills dividing cells).

4.  **Evaluate the senses:**
    *   **Sense 1:** "the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty." (This refers to a field of study, e.g., internal medicine. Incorrect.)
    *   **Sense 2:** "(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug." (This refers to a substance used for therapeutic or preventative purposes. Pemetrexed is a cytotoxic drug/substance. This fits.)
    *   **Sense 3:** "the learned profession that is mastered by graduate training in a medical school..." (This refers to the profession/field of study, e.g., "He studied medicine." Incorrect.)
    *   **Sense 4:** "punishment for one's actions | synonyms=music..." (This is an idiom/punishment. Incorrect.)

5.  **Conclusion:** The usage "a cytotoxic medicine" refers to a drug/substance, which matches Sense 2.

6.  **Final Output Generation:** Return only the number 2.


[User]
Which numbered sense of "kill" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=cause to die; put to death, usually intentionally or knowingly | examples=This man killed several people when he tried to rob a bank; The farmer killed a pig for the holidays
2. definition=thwart the passage of | synonyms=shoot down, defeat, vote down, vote out | examples=kill a motion; he shot down the student's proposal
3. definition=end or extinguish by forceful means | synonyms=stamp out | examples=Stamp out poverty!
4. definition=be fatal | examples=cigarettes kill; drunken driving kills
5. definition=be the source of great pain for | examples=These new shoes are killing me!
6. definition=overwhelm with hilarity, pleasure, or admiration | examples=The comedian was so funny, he was killing me!
7. definition=hit with so much force as to make a return impossible, in racket games | examples=She killed the ball
8. definition=hit with great force | examples=He killed the ball
9. definition=deprive of life | examples=AIDS has killed thousands in Africa
10. definition=cause the death of, without intention | examples=She was killed in the collision of three cars
11. definition=drink down entirely | synonyms=toss off, pop, bolt down, belt down, pour down, down | examples=He downed three martinis before dinner; She killed a bottle of brandy that night
12. definition=mark for deletion, rub off, or erase | synonyms=obliterate, wipe out | examples=kill these lines in the President's speech
13. definition=tire out completely | examples=The daily stress of her work is killing her
14. definition=cause to cease operating | examples=kill the engine
15. definition=destroy a vitally essential quality of or in | examples=Eating artichokes kills the taste of all other foods

reasoning_content:
1.  **Analyze the context:** The phrase is "a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells)".
2.  **Determine the meaning of "kills" in this context:** The medicine (pemetrexed) causes the cells (cancer cells) to die.
3.  **Examine the senses provided:** I need to find the sense that means "to cause something to die" or "to destroy life/function" in a biological context.

    *   1. cause to die; put to death, usually intentionally or knowingly (Applies to living beings, often humans/animals).
    *   2. thwart the passage of (Defeat/stop). (Incorrect)
    *   3. end or extinguish by forceful means (Usually fire/light/abstract concepts). (Less likely)
    *   4. be fatal (The medicine *is* fatal, but the verb "kills" is used actively). (Incorrect usage)
    *   5. be the source of great pain for (Figurative, emotional). (Incorrect)
    *   6. overwhelm with hilarity (Figurative, emotional). (Incorrect)
    *   7. hit with so much force (Sports). (Incorrect)
    *   8. hit with great force (Sports). (Incorrect)
    *   9. deprive of life (Causes death). (Strong candidate)
    *   10. cause the death of, without intention (Accidental death). (Incorrect, this is intentional/therapeutic action)
    *   11. drink down entirely (Consumption). (Incorrect)
    *   12. mark for deletion, rub off, or erase (Deletion). (Incorrect)
    *   13. tire out completely (Figurative, exhaustion). (Incorrect)
    *   14. cause to cease operating (Machine/system). (Possible, but less precise than biological death)
    *   15. destroy a vitally essential quality of or in (Destroying a quality/taste). (Incorrect)

4.  **Compare the best candidates (1, 9, 10):**
    *   The context is about a medicine *causing* cells to die.
    *   Sense 1: "cause to die; put to death, usually intentionally or knowingly." This fits the therapeutic action of a cytotoxic drug.
    *   Sense 9: "deprive of life." This is a very accurate description of what a cytotoxic drug does to cells.
    *   Sense 10: "cause the death of, without intention." This is incorrect because the drug is designed to kill the cancer cells (intentional action).

5.  **Refine the choice between 1 and 9:**
    *   Sense 1 is broad ("put to death").
    *   Sense 9 is specific ("deprive of life").
    *   In the context of biological action (cytotoxicity), "deprive of life" (Sense 9) is the most precise definition for the action of a substance causing cellular death. However, Sense 1 ("cause to die") also applies perfectly.

6.  **Re-evaluating the provided senses and typical usage:** When a drug is described as "killing cells," it means it is causing them to die. Sense 9 ("deprive of life") is the most direct and scientifically accurate match for the action of a cytotoxic agent on cells.

7.  **Final check:** "A medicine that kills cells" = "A medicine that deprives cells of life." (Sense 9).


[User]
Which numbered sense of "cell" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=any small compartment | examples=the cells of a honeycomb
2. definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. definition=small room in which a monk or nun lives | synonyms=cubicle
7. definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

reasoning_content:
1.  **Analyze the context:** The phrase is "a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells)".
2.  **Determine the meaning of "cells" in this context:** The context discusses cancer cells, DNA, RNA, nucleotides, and biological processes (dividing).
3.  **Evaluate the provided senses:**
    *   1. any small compartment (e.g., honeycomb cells) - Too general, not specific to biology/cancer.
    *   2. (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life... - This perfectly matches "cancer cells" and the discussion of DNA/RNA/nucleotides.
    *   3. a device that delivers an electric current (electric cell) - Incorrect (technology/chemistry).
    *   4. a small unit serving as part of or as the nucleus of a larger political movement (cadre) - Incorrect (politics).
    *   5. a hand-held mobile radiotelephone (cellular phone) - Incorrect (technology).
    *   6. small room in which a monk or nun lives (cubicle) - Incorrect (architecture/religious life).
    *   7. a room where a prisoner is kept (jail cell) - Incorrect (architecture/prison).
4.  **Select the correct sense number:** Sense 2 is the correct biological definition.
5.  **Format the output:** Return only the number.


[User]
Which numbered sense of "divide" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire after World War I
2. definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven?
3. definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries
4. definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated
5. definition=make a division or separation | synonyms=separate
6. definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea

reasoning_content:
1.  **Analyze the request:** The user wants to identify which numbered sense of the word "divide" (or a related concept, as the target word is "dividing") is used in the provided context. The output must be only the number.

2.  **Analyze the context:** The relevant phrase is: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells)..."

3.  **Determine the meaning of "dividing" in this context:**
    *   The medicine kills cells that are *dividing*.
    *   Cell division is the process of a cell splitting into two or more daughter cells (mitosis, meiosis, etc.).
    *   Therefore, "dividing" here means undergoing the process of separation or replication into multiple parts.

4.  **Examine the senses of "divide":**

    *   1. definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire after World War I
        *   *Relevance:* This sense relates to splitting into parts. Cell division fits this concept (a cell splits into parts/new cells).

    *   2. definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven?
        *   *Relevance:* Mathematical division. Incorrect.

    *   3. definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries
        *   *Relevance:* Separation by location/barrier. Incorrect.

    *   4. definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated
        *   *Relevance:* Passive action of separating. While cell division involves separation, this sense usually implies things breaking apart naturally, not the active biological process of replication.

    *   5. definition=make a division or separation | synonyms=separate
        *   *Relevance:* General separation. Similar to 1, but 1 is more specific to splitting into parts.

    *   6. definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea
        *   *Relevance:* Forced separation. Incorrect.

5.  **Compare the biological meaning to the senses:**
    *   The biological process of cell division is fundamentally the act of separating into parts (splitting).
    *   Sense 1 ("separate into parts or portions") is the most accurate fit for the biological process of a cell splitting/replicating.

6.  **Final Selection:** Sense 1.


[User]
Which numbered sense of "body" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Senses:
1. definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
2. definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium; the student body
3. definition=a natural object consisting of a dead animal or person | synonyms=dead body | examples=they found the body in the lake
4. definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. definition=the body excluding the head and neck and limbs | synonyms=torso, trunk | examples=they moved their arms and legs and bodies
6. definition=a collection of particulars considered as a system | examples=a body of law; a body of doctrine
7. definition=the property of holding together and retaining its shape | synonyms=consistency, consistence, eubstance | examples=wool has more body than rayon; when the dough has enough consistency it is ready to bake
8. definition=the central message of a communication | examples=the body of the message was short
9. definition=the main mass of a thing
10. definition=a resonating chamber in a musical instrument (as the body of a violin) | synonyms=soundbox
11. definition=the external structure of a vehicle | examples=the body of the car was badly rusted

reasoning_content:
1.  **Analyze the context:** The sentence is: "In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

2.  **Determine the meaning of "body" in this context:** The context is discussing how a drug (pemetrexed) is metabolized (converted) into an active form within a biological system (the human/patient). Metabolism and conversion of substances happen within the physical structure of the organism.

3.  **Evaluate the senses provided:**

    *   1. definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
    *   2. definition=a group of persons...
    *   3. definition=a natural object consisting of a dead animal or person
    *   4. definition=an individual 3-dimensional object that has mass...
    *   5. definition=the body excluding the head and neck and limbs
    *   6. definition=a collection of particulars considered as a system
    *   7. definition=the property of holding together and retaining its shape
    *   8. definition=the central message of a communication
    *   9. definition=the main mass of a thing
    *   10. definition=a resonating chamber in a musical instrument
    *   11. definition=the external structure of a vehicle

4.  **Match the meaning to the best sense:** The conversion of a drug into an active form happens within the living organism. Sense 1, "the entire structure of an organism (an animal, plant, or human being)," perfectly matches this biological context.

5.  **Select the corresponding number:** The number is 1.


[User]
Which numbered sense of "convert" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Senses:
1. definition=change from one system to another or to a new plan or policy | synonyms=change over | examples=We converted from 220 to 110 Volt
2. definition=change the nature, purpose, or function of something | examples=convert lead into gold; convert hotels into jails
3. definition=change religious beliefs, or adopt a religious belief | examples=She converted to Buddhism
4. definition=exchange or replace with another, usually of the same kind or category | synonyms=change, exchange, commute | examples=Could you convert my dollars into pounds?; He changed his name
5. definition=cause to adopt a new or different faith | examples=The missionaries converted the Indian population
6. definition=score an extra point or points after touchdown by kicking the ball through the uprights or advancing the ball into the end zone | examples=Smith converted and his team won
7. definition=complete successfully | examples=score a penalty shot or free throw
8. definition=score (a spare)
9. definition=make (someone) agree, understand, or realize the truth or validity of something | synonyms=win over, convince | examples=He had finally convinced several customers of the advantages of his product
10. definition=exchange a penalty for a less severe one | synonyms=commute, exchange
11. definition=change in nature, purpose, or function; undergo a chemical change | examples=The substance converts to an acid

reasoning_content:
1.  **Analyze the context:** The sentence is: "In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes..."
2.  **Identify the action:** The substance (pemetrexed) is changing into another substance (an active form). This is a chemical process happening within the body.
3.  **Examine the senses provided:** I need to find the sense that describes a chemical change or a change in nature/function of a substance.
    *   1. Change from one system to another (e.g., voltage). (No)
    *   2. Change the nature, purpose, or function of something (e.g., lead into gold). (Possible, but maybe too broad.)
    *   3. Change religious beliefs. (No)
    *   4. Exchange or replace (e.g., dollars into pounds). (No, this is a chemical transformation, not an exchange of items.)
    *   5. Cause to adopt a new faith. (No)
    *   6. Score an extra point (sports). (No)
    *   7. Complete successfully (sports). (No)
    *   8. Score a spare (sports). (No)
    *   9. Make someone agree/convince. (No)
    *   10. Exchange a penalty. (No)
    *   11. Change in nature, purpose, or function; undergo a chemical change (e.g., substance converts to an acid). (This perfectly matches the context of a drug being metabolized/chemically transformed into an active form.)
4.  **Select the best fit:** Sense 11 is the most precise definition for a chemical transformation of a substance in a biological system.
5.  **Final check:** Pemetrexed (substance) -> Active form (new substance) via chemical change. Sense 11: "undergo a chemical change." (Match confirmed).


[User]
Which numbered sense of "active" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Senses:
1. definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. definition=exerting influence or producing a change or effect | examples=an active ingredient
7. definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. definition=(of e.g. volcanos) capable of erupting
13. definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

reasoning_content:
1.  **Analyze the context:** The phrase is "In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes..."
2.  **Determine the meaning of "active" in this specific context:** Here, "active" refers to the form of the drug (pemetrexed) that is biologically functional or effective. It is the form that performs the action (blocking enzyme activity).
3.  **Examine the senses provided:**
    *   1. Tending to become more severe/wider in scope (e.g., active tuberculosis). (No)
    *   2. Engaged in military operations. (No)
    *   3. Disposed to take action or effectuate change (e.g., active antagonism). (Close, but usually refers to intent/disposition, not chemical function.)
    *   4. Taking part in an activity. (No)
    *   5. Characterized by energetic activity (e.g., active toddler). (No)
    *   6. Exerting influence or producing a change or effect (e.g., an active ingredient). (Yes, this perfectly matches the concept of a biologically functional drug form.)
    *   7. Full of activity or engaged in continuous activity (e.g., active seaport). (No)
    *   8. In operation (e.g., keep hope alive). (No)
    *   9. Solar activity. (No)
    *   10. Semantic function of actor (Grammar). (No)
    *   11. Expressing action rather than a state of being (Grammar). (No)
    *   12. Capable of erupting (Volcanoes). (No)
    *   13. Erupting or liable to erupt (Volcanoes). (No)
    *   14. Engaged in full-time work. (No)
4.  **Match the meaning to the best sense:** The context describes a chemical form that *performs* a function (blocks enzyme activity). Sense 6, "exerting influence or producing a change or effect," and its example "an active ingredient," is the precise definition used in pharmacology and chemistry.
5.  **Select the corresponding number:** Sense 6.


[User]
Which numbered sense of "form" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Senses:
1. definition=the phonological or orthographic sound or appearance of a word that can be used to describe or identify something | synonyms=word form, signifier, descriptor | examples=the inflected forms of a word can be represented by a stem and a list of inflections to be attached
2. definition=a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety | examples=sculpture is a form of art; what kinds of desserts are there?
3. definition=a perceptual structure | synonyms=shape, pattern | examples=the composition presents problems for students of musical form; a visual pattern must include not only objects but the spaces between them
4. definition=any spatial attributes (especially as defined by outline) | synonyms=shape, configuration, contour, conformation | examples=he could barely make out their shapes
5. definition=alternative names for the body of a human being | synonyms=human body, physical body, material body, soma, build, figure | examples=Leonardo studied the human body; he has a strong physique
6. definition=the spatial arrangement of something as distinct from its substance | synonyms=shape | examples=geometry is the mathematical science of shape
7. definition=the visual appearance of something or someone | synonyms=shape, cast | examples=the delicate cast of his features
8. definition=a printed document with spaces in which to write | examples=he filled out his tax form
9. definition=(biology) a group of organisms within a species that differ in trivial ways from similar groups | synonyms=variant, strain, var. | examples=a new strain of microorganisms
10. definition=an arrangement of the elements in a composition or discourse | examples=the essay was in the form of a dialogue; he first sketches the plot in outline form
11. definition=a particular mode in which something is manifested | examples=his resentment took the form of extreme hostility
12. definition=(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary | synonyms=phase | examples=the reaction occurs in the liquid phase of the system
13. definition=a body of students who are taught together | synonyms=class, grade, course | examples=early morning classes are always sleepy
14. definition=an ability to perform well | examples=he was at the top of his form; the team was off form last night
15. definition=a life-size dummy used to display clothes | synonyms=mannequin, manikin, mannikin, manakin
16. definition=a mold for setting concrete | examples=they built elaborate forms for pouring the foundation

reasoning_content:
1.  **Analyze the context:** The sentence is: "In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides..."

2.  **Determine the meaning of "form" in this context:** Pemetrexed (the drug) is converted into an *active* form. This refers to a chemical transformation, where the original substance changes into a new, functional chemical entity.

3.  **Evaluate the senses provided:** I need a sense that relates to a specific chemical or functional state/structure resulting from a conversion process.

    *   1. Phonological/orthographic sound/appearance (No, it's chemical).
    *   2. Category/kind (Possible, but usually too broad. It's a specific chemical entity, not just a category).
    *   3. Perceptual structure/shape/pattern (No, this is chemical, not visual/perceptual).
    *   4. Spatial attributes/outline (No, this is chemical, not spatial).
    *   5. Alternative names for the body (No, this is about the drug's structure).
    *   6. Spatial arrangement (No, this is chemical, not spatial).
    *   7. Visual appearance (No, this is chemical, not visual).
    *   8. Printed document (No).
    *   9. Biological group/strain (No, this is a chemical conversion).
    *   10. Arrangement of elements in a composition/discourse (No, this is chemical).
    *   11. A particular mode in which something is manifested (Yes. A chemical conversion results in a specific *mode* or *manifestation* of activity/structure).
    *   12. (Physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary (This is highly relevant. A drug conversion often involves changing its chemical state or structure to become active, which aligns with a distinct chemical/physical state).
    *   13. Group of students (No).
    *   14. Ability to perform well (No).
    *   15. Dummy/mannequin (No).
    *   16. Mold (No).

4.  **Compare the best candidates (11 and 12):**

    *   Sense 11: "a particular mode in which something is manifested." (The drug manifests its activity in this new form.)
    *   Sense 12: "(physical chemistry) a distinct state of matter in a system..." (The conversion creates a new chemical/physical state.)

    In pharmacology, when a drug is converted into an "active form," it is often referred to as a metabolite or an active chemical species. Sense 12, specifically mentioning "physical chemistry" and "distinct state of matter," is the most precise technical definition for a chemical transformation resulting in a new, functional entity. Sense 11 is more general ("mode of manifestation"), while Sense 12 addresses the underlying chemical reality of the conversion.

5.  **Final Selection:** Sense 12 is the most accurate technical fit for a chemical conversion resulting in an active substance.


[User]
Which numbered sense of "block" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Senses:
1. definition=render unsuitable for passage | synonyms=barricade, blockade, stop, block off, block up, bar | examples=block the way; barricade the streets
2. definition=hinder or prevent the progress or accomplishment of | synonyms=obstruct, blockade, hinder, stymie, stymy, embarrass | examples=His brother blocked him at every turn
3. definition=stop from happening or developing | synonyms=stop, halt, kibosh | examples=Block his election; Halt the process
4. definition=interfere with or prevent the reception of signals | synonyms=jam | examples=Jam the Voice of America; block the signals emitted by this station
5. definition=run on a block system | examples=block trains
6. definition=interrupt the normal function of by means of anesthesia | examples=block a nerve; block a muscle
7. definition=shut out from view or get in the way so as to hide from sight | synonyms=obstruct | examples=The thick curtain blocked the action on the stage; The trees obstruct my view of the mountains
8. definition=stamp or emboss a title or design on a book with a block | examples=block the book cover
9. definition=obstruct | synonyms=stuff, lug, choke up | examples=My nose is all stuffed; Her arteries are blocked
10. definition=block passage through | synonyms=obstruct, obturate, impede, occlude, jam, close up | examples=obstruct the path
11. definition=support, secure, or raise with a block | examples=block a plate for printing; block the wheels of a car
12. definition=impede the movement of (an opponent or a ball) | synonyms=parry, deflect | examples=block an attack
13. definition=be unable to remember | synonyms=forget, blank out, draw a blank | examples=I'm drawing a blank; You are blocking the name of your first wife!
14. definition=shape by using a block | examples=Block a hat; block a garment
15. definition=shape into a block or blocks | examples=block the graphs so one can see the results clearly
16. definition=prohibit the conversion or use of (assets) | synonyms=freeze, immobilize, immobilise | examples=Blocked funds; Freeze the assets of this hostile government

reasoning_content:
1.  **Analyze the context:** The sentence is: "In the body, pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides..."
2.  **Determine the meaning of "blocks" in this context:** The active form of the drug (pemetrexed) is interfering with or stopping the function (activity) of specific enzymes.
3.  **Examine the senses provided:** I need to find the sense that means to stop, hinder, or prevent a process or function.

    *   1. render unsuitable for passage (Physical barrier) - No.
    *   2. hinder or prevent the progress or accomplishment of (General obstruction/hindrance) - Plausible.
    *   3. stop from happening or developing (Cessation of a process) - Very plausible.
    *   4. interfere with or prevent the reception of signals (Signal jamming) - No.
    *   5. run on a block system (Specific usage) - No.
    *   6. interrupt the normal function of by means of anesthesia (Medical/Anesthesia specific) - No.
    *   7. shut out from view or get in the way so as to hide from sight (Visual obstruction) - No.
    *   8. stamp or emboss a title or design on a book (Printing/Physical action) - No.
    *   9. obstruct (Stuffing/Arterial blockage) - Plausible, but perhaps too physical.
    *   10. block passage through (Physical blockage/Occlusion) - No (The enzymes are not a physical passage).
    *   11. support, secure, or raise with a block (Construction/Support) - No.
    *   12. impede the movement of (Sports/Physical deflection) - No.
    *   13. be unable to remember (Mental state) - No.
    *   14. shape by using a block (Sculpting) - No.
    *   15. shape into a block or blocks (Molding) - No.
    *   16. prohibit the conversion or use of (Financial/Legal restriction) - No.

4.  **Compare the best candidates (2 and 3):**
    *   Sense 2: "hinder or prevent the progress or accomplishment of" (e.g., hindering a process).
    *   Sense 3: "stop from happening or developing" (e.g., stopping a process).

    In the context of enzyme activity, the drug is *stopping* or *inhibiting* the function. Both 2 and 3 fit the concept of inhibition. However, Sense 3 ("stop from happening or developing") is the most direct and general fit for stopping a biological process (the production of nucleotides). Sense 2 is slightly broader (hinder/prevent progress).

5.  **Final Selection:** Sense 3 captures the meaning of inhibiting or stopping a biological function most accurately.


[User]
Which numbered sense of "involved" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Senses:
1. definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved; the problems involved
2. definition=entangled or hindered as if e.g. in mire | synonyms=mired | examples=the difficulties in which the question is involved; brilliant leadership mired in details and confusion
3. definition=emotionally involved
4. definition=highly complex or intricate and occasionally devious; ; ; ; ; ; ; ; - Sir Walter Scott | synonyms=Byzantine, convoluted, knotty, tangled, tortuous | examples=the Byzantine tax structure; Byzantine methods for holding on to his chairmanship
5. definition=enveloped | examples=a castle involved in mist; the difficulties in which the question is involved

reasoning_content:
1.  **Analyze the context:** The phrase is "the enzymes that are <t>involved</t> in producing nucleotides."
2.  **Determine the meaning of "involved" in this specific context:** Enzymes are participating in a process (producing nucleotides). They are actively taking part in the reaction.
3.  **Examine the senses provided:**
    *   **Sense 1:** definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved; the problems involved. (This matches the idea of participation/association.)
    *   **Sense 2:** definition=entangled or hindered as if e.g. in mire | synonyms=mired | examples=the difficulties in which the question is involved; brilliant leadership mired in details and confusion. (This suggests being stuck or hindered, which doesn't fit enzymes producing nucleotides.)
    *   **Sense 3:** definition=emotionally involved. (Irrelevant to enzymes.)
    *   **Sense 4:** definition=highly complex or intricate and occasionally devious. (Irrelevant to enzymes.)
    *   **Sense 5:** definition=enveloped | examples=a castle involved in mist; the difficulties in which the question is involved. (This suggests being covered or surrounded, which doesn't fit enzymes.)
4.  **Match the context meaning to the best sense:** The enzymes are *participating* in the production of nucleotides. Sense 1, "connected by participation or association or use," is the correct fit.
5.  **Select the corresponding number:** Sense 1.