[User]
Which numbered sense of "more" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: For <t>more</t> information, see the Summary of Product Characteristics (also part of the EPAR).

Senses:
1. definition=(comparative of `much' used with mass nouns) a quantifier meaning greater in size or amount or extent or degree | examples=more land
2. definition=(comparative of `many' used with count nouns) quantifier meaning greater in number | examples=a hall with more seats

reasoning_content:
1.  **Analyze the request:** The user wants to identify which numbered sense of "more" is used in the sentence: "For more information, see the Summary of Product Characteristics (also part of the EPAR)." The output must be only the number.

2.  **Analyze the target word and context:**
    *   Word: "more"
    *   Context: "For more information"
    *   Noun modified: "information"

3.  **Determine the nature of the noun "information":**
    *   "Information" is an uncountable (mass) noun.

4.  **Analyze the senses provided:**
    *   Sense 1: (comparative of `much' used with mass nouns) a quantifier meaning greater in size or amount or extent or degree | examples=more land
    *   Sense 2: (comparative of `many' used with count nouns) quantifier meaning greater in number | examples=a hall with more seats

5.  **Match the usage to the sense:**
    *   The usage is "more information."
    *   "Information" is a mass noun.
    *   Sense 1 deals with mass nouns (comparative of 'much').
    *   Sense 2 deals with count nouns (comparative of 'many').

6.  **Conclusion:** Sense 1 is the correct sense.

7.  **Format the output:** Return only the number.


attempt_kind: initial

status: success

[User]
Which numbered sense of "information" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: For more <t>information</t>, see the Summary of Product Characteristics (also part of the EPAR).

Senses:
1. definition=a message received and understood
2. definition=knowledge acquired through study or experience or instruction
3. definition=formal accusation of a crime
4. definition=a collection of facts from which conclusions may be drawn | examples=statistical data
5. definition=(communication theory) a numerical measure of the uncertainty of an outcome | examples=the signal contained thousands of bits of information

finish_reason: stop

role: assistant

reasoning_content:
1.  **Analyze the request:** The user wants to identify which numbered sense of the word "information" (marked with `<t>`) is used in the given sentence. The output must be *only* the number.

2.  **Analyze the sentence:** "For more <t>information</t>, see the Summary of Product Characteristics (also part of the EPAR)."

3.  **Determine the context of "information":** In this context (a medical/product document reference), "information" refers to details, facts, or knowledge provided to the reader about the product.

4.  **Evaluate the senses:**

    *   **Sense 1:** definition=a message received and understood. (This fits, as the document provides a message/details.)
    *   **Sense 2:** definition=knowledge acquired through study or experience or instruction. (This also fits, as the reader is acquiring knowledge/details about the product.)
    *   **Sense 3:** definition=formal accusation of a crime. (Incorrect. This is "information" in a legal sense, e.g., "information against him.")
    *   **Sense 4:** definition=a collection of facts from which conclusions may be drawn | examples=statistical data. (This fits well. The Summary of Product Characteristics is a collection of facts/data.)
    *   **Sense 5:** definition=(communication theory) a numerical measure of the uncertainty of an outcome | examples=the signal contained thousands of bits of information. (Incorrect. This is technical/mathematical.)

5.  **Refine the choice (1, 2, or 4):**
    *   The phrase "For more information" is a common request for *details* or *facts*.
    *   Sense 4 ("a collection of facts...") is the most precise fit for what a "Summary of Product Characteristics" *is*. It is a structured collection of facts.
    *   Sense 2 ("knowledge acquired...") describes the *result* of reading the information.
    *   Sense 1 ("a message received...") describes the *delivery* of the information.

    In common usage, when referring to documentation or data, Sense 4 (collection of facts/data) is the strongest and most encompassing definition.

6.  **Final Selection:** Sense 4.

7.  **Format the output:** Return only the number.

currency: USD

source: unavailable


[User]
Which numbered sense of "see" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR).

Senses:
1. definition=perceive by sight or have the power to perceive by sight | examples=You have to be a good observer to see all the details
2. definition=perceive (an idea or situation) mentally | examples=Now I see!
3. definition=perceive or be contemporaneous with | examples=We found Republicans winning the offices
4. definition=imagine; conceive of; see in one's mind | examples=I can't see him on horseback!
5. definition=deem to be | examples=She views this quite differently from me
6. definition=get to know or become aware of, usually accidentally | examples=I learned that she has two grown-up children
7. definition=see or watch | examples=view a show on television
8. definition=come together | examples=I'll probably see you at the meeting
9. definition=find out, learn, or determine with certainty, usually by making an inquiry or other effort | examples=I want to see whether she speaks French
10. definition=be careful or certain to do something; make certain of something | examples=He verified that the valves were closed
11. definition=go to see for professional or business reasons | examples=You should see a lawyer
12. definition=go to see for a social visit | examples=I went to see my friend Mary the other day
13. definition=go to see a place, as for entertainment | examples=We went to see the Eiffel Tower in the morning
14. definition=take charge of or deal with | examples=Could you see about lunch?
15. definition=receive as a specified guest | examples=the doctor will see you now
16. definition=date regularly; have a steady relationship with | examples=Did you know that she is seeing an older man?
17. definition=see and understand, have a good eye | examples=The artist must first learn to see
18. definition=deliberate or decide | examples=See whether you can come tomorrow
19. definition=observe as if with an eye | examples=The camera saw the burglary and recorded it
20. definition=observe, check out, and look over carefully or inspect | examples=The customs agent examined the baggage
21. definition=go or live through | examples=We had many trials to go through
22. definition=accompany or escort | examples=I'll see you to the door
23. definition=match or meet | examples=I saw the bet of one of my fellow players
24. definition=make sense of; assign a meaning to | examples=What message do you see in this letter?

reasoning_content:
1.  **Analyze the sentence:** "For more information, see the Summary of Product Characteristics (also part of the EPAR)."
2.  **Identify the usage of "see":** In this context, "see" is an imperative verb instructing the reader to look at or consult the specified document (the Summary of Product Characteristics).
3.  **Examine the definitions provided:** I need to find a definition that matches the meaning of "consult" or "refer to."
    *   1. perceive by sight (No, it's an instruction, not a description of perception).
    *   2. perceive mentally (No).
    *   3. perceive or be contemporaneous with (No).
    *   4. imagine (No).
    *   5. deem to be (No).
    *   6. get to know or become aware of (Possible, but usually implies accidental discovery).
    *   7. see or watch (Too general, usually implies visual observation).
    *   8. come together (No).
    *   9. find out, learn, or determine with certainty, usually by making an inquiry or other effort (This fits the context of consulting a document for information).
    *   10. be careful or certain to do something (No).
    *   11. go to see for professional or business reasons (This is close, as consulting a document is a professional action, but 9 is more precise for the *action* of the reader).
    *   12. go to see for a social visit (No).
    *   13. go to see a place (No).
    *   14. take charge of or deal with (No).
    *   15. receive as a specified guest (No).
    *   16. date regularly (No).
    *   17. see and understand (No).
    *   18. deliberate or decide (No).
    *   19. observe as if with an eye (No).
    *   20. observe, check out, and look over carefully or inspect (This is also a strong candidate, as reading a document is a form of inspection/checking).
    *   21. go or live through (No).
    *   22. accompany or escort (No).
    *   23. match or meet (No).
    *   24. make sense of; assign a meaning to (No).
4.  **Compare the best candidates (9, 11, 20):**
    *   *9. find out, learn, or determine with certainty, usually by making an inquiry or other effort.* (The reader is making an effort (reading/consulting) to find out information.)
    *   *11. go to see for professional or business reasons.* (This describes the *purpose* of the action, but 9 describes the *cognitive outcome* of the action.)
    *   *20. observe, check out, and look over carefully or inspect.* (This describes the *method* of the action—reading/inspecting the document.)

5.  **Refine the choice:** When a text says "see [document]," it is instructing the reader to *consult* the document to *obtain* information. Definition 9 ("find out, learn, or determine with certainty...") captures the goal and function of this instruction most accurately. Definition 20 is also plausible (inspecting the document), but 9 focuses on the informational purpose, which is the primary function of this instruction in technical writing.

6.  **Final Selection:** Sense 9.


[User]
Which numbered sense of "product" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR).

Senses:
1. definition=commodities offered for sale | examples=good business depends on having good merchandise
2. definition=an artifact that has been created by someone or some process | examples=they improve their product every year
3. definition=a quantity obtained by multiplication | examples=the product of 2 and 3 is 6
4. definition=a chemical substance formed as a result of a chemical reaction | examples=a product of lime and nitric acid
5. definition=a consequence of someone's efforts or of a particular set of circumstances | examples=skill is the product of hours of practice
6. definition=the set of elements common to two or more sets | examples=the set of red hats is the intersection of the set of hats and the set of red things

reasoning_content:
1.  **Analyze the request:** The user wants to identify which numbered sense of the word "Product" is used in the given sentence. The output must be only the number.

2.  **Analyze the sentence:** "For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR)."

3.  **Analyze the context:** The word "Product" is modified by "Characteristics" and is related to "EPAR" (likely a technical or business document, like an Environmental Product Assessment Report). This strongly suggests a manufactured item or a service offered.

4.  **Evaluate the senses:**

    *   **1. definition=commodities offered for sale | examples=good business depends on having good merchandise:** This fits the context of a business/technical document describing items for sale.
    *   **2. definition=an artifact that has been created by someone or some process | examples=they improve their product every year:** This is a general definition of a manufactured item. It is highly relevant.
    *   **3. definition=a quantity obtained by multiplication | examples=the product of 2 and 3 is 6:** (Mathematical product). Does not fit.
    *   **4. definition=a chemical substance formed as a result of a chemical reaction | examples=a product of lime and nitric acid:** (Chemical product). Does not fit.
    *   **5. definition=a consequence of someone's efforts or of a particular set of circumstances | examples=skill is the product of hours of practice:** (Result/Outcome). Does not fit.
    *   **6. definition=the set of elements common to two or more sets | examples=the set of red hats is the intersection of the set of hats and the set of red things:** (Set theory/Intersection). Does not fit.

5.  **Compare relevant senses (1 and 2):**
    *   Sense 2 ("an artifact that has been created by someone or some process") is the most general definition of a manufactured item.
    *   Sense 1 ("commodities offered for sale") is a specific application of Sense 2, often used in commercial contexts.

    In the context of "Product Characteristics" within a technical/business document (EPAR), the item being described is a tangible or defined entity that has been created. Both 1 and 2 are plausible, but Sense 2 is the fundamental definition of the *thing* whose characteristics are being summarized. Sense 1 focuses on the *commercial status* of the thing. Since the sentence is about summarizing the *characteristics* of the item itself, Sense 2 is the most accurate and encompassing definition.

6.  **Final Selection:** Sense 2.


[User]
Which numbered sense of "part" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR).

Senses:
1. definition=something determined in relation to something that includes it | examples=he wanted to feel a part of something bigger than himself
2. definition=something less than the whole of a human artifact | examples=the rear part of the house
3. definition=a portion of a natural object | examples=they analyzed the river into three parts
4. definition=that which concerns a person with regard to a particular role or situation | examples=it requires vigilance on our part
5. definition=the extended spatial location of something | examples=the farming regions of France
6. definition=the actions and activities assigned to or required or expected of a person or group | examples=the function of a teacher
7. definition=an actor's portrayal of someone in a play | examples=she played the part of Desdemona
8. definition=assets belonging to or due to or contributed by an individual person or group | examples=he wanted his share in cash
9. definition=one of the portions into which something is regarded as divided and which together constitute a whole | examples=the written part of the exam
10. definition=a line of scalp that can be seen when sections of hair are combed in opposite directions | examples=his part was right in the middle
11. definition=the melody carried by a particular voice or instrument in polyphonic music | examples=he tried to sing the tenor part
12. definition=the part played by a person in bringing about a result | examples=I am proud of my contribution in advancing the project

reasoning_content:
1.  **Analyze the sentence:** "For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR)."
2.  **Identify the target word and context:** The word is "part," and the context is "Summary of Product Characteristics... of the EPAR."
3.  **Determine the relationship between the two nouns:** A "Summary of Product Characteristics" is a component or section *of* the "EPAR" (European Public Assessment Report, presumably).
4.  **Evaluate the senses provided:** I need a sense that describes a component or section of a larger whole document/artifact.

    *   1. something determined in relation to something that includes it (e.g., feeling a part of something bigger). (No)
    *   2. something less than the whole of a human artifact (e.g., the rear part of the house). (Plausible, as a document is a human artifact, and the summary is a section.)
    *   3. a portion of a natural object (e.g., river into three parts). (No, EPAR is not a natural object.)
    *   4. that which concerns a person (e.g., on our part). (No)
    *   5. the extended spatial location of something (e.g., farming regions). (No)
    *   6. the actions and activities assigned to or required (e.g., function of a teacher). (No)
    *   7. an actor's portrayal (e.g., played the part of Desdemona). (No)
    *   8. assets belonging to or due to (e.g., his share in cash). (No)
    *   9. one of the portions into which something is regarded as divided and which together constitute a whole (e.g., the written part of the exam). (Highly plausible. The Summary is a division/section of the EPAR.)
    *   10. a line of scalp (e.g., his part was right in the middle). (No)
    *   11. the melody (e.g., tenor part). (No)
    *   12. the part played by a person in bringing about a result (e.g., my contribution). (No)

5.  **Compare Senses 2 and 9:**
    *   Sense 2: "something less than the whole of a human artifact" (Focuses on physical/structural location within the artifact).
    *   Sense 9: "one of the portions into which something is regarded as divided and which together constitute a whole" (Focuses on conceptual division or composition).

    In the context of a document (EPAR), the Summary of Product Characteristics is a conceptual division or section that makes up the whole document. Sense 9 is the most precise and standard definition for a component section of a larger work (like a chapter, section, or summary).

6.  **Conclusion:** Sense 9 fits the context best.


[User]
Which numbered sense of "active" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites.

Senses:
1. definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. definition=engaged in or ready for military or naval operations | examples=on active duty
3. definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations
4. definition=taking part in an activity | examples=an active member of the club
5. definition=characterized by energetic activity | examples=an active toddler
6. definition=exerting influence or producing a change or effect | examples=an active ingredient
7. definition=full of activity or engaged in continuous activity | examples=an active seaport
8. definition=in operation | examples=keep hope alive
9. definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being
12. definition=(of e.g. volcanos) capable of erupting
13. definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. definition=engaged in full-time work | examples=active duty

reasoning_content:
1.  **Analyze the target word and sentence:** The word is "active" in the sentence: "The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine..."

2.  **Determine the meaning of "active" in this context:** The sentence describes a substance (Alimta/pemetrexed) that is a "cytotoxic medicine" (a medicine that kills cells). For a medicine to be cytotoxic, it must *do* something—it must exert a chemical effect or influence on the cells.

3.  **Examine the provided senses:** I need to find the sense that relates to a substance having a functional effect or influence.

    *   1. tending to become more severe or wider in scope (e.g., active tuberculosis) -> No.
    *   2. engaged in or ready for military or naval operations (e.g., on active duty) -> No.
    *   3. disposed to take action or effectuate change (e.g., a director who takes an active interest) -> Possible, but usually applied to people/agents.
    *   4. taking part in an activity (e.g., an active member) -> No.
    *   5. characterized by energetic activity (e.g., an active toddler) -> No.
    *   6. exerting influence or producing a change or effect (e.g., an active ingredient) -> **Strong match.** A medicine is an "active ingredient" that exerts a cytotoxic effect.
    *   7. full of activity or engaged in continuous activity (e.g., an active seaport) -> No.
    *   8. in operation (e.g., keep hope alive) -> No.
    *   9. (of the sun) characterized by an increased occurrence of sunspots and flares -> No.
    *   10. expressing that the subject of the sentence has the semantic function of actor (linguistic sense) -> No.
    *   11. (used of verbs...) expressing action rather than a state of being (linguistic sense) -> No.
    *   12. (of e.g. volcanos) capable of erupting -> No.
    *   13. (of e.g. volcanos) erupting or liable to erupt (e.g., active volcanos) -> No.
    *   14. engaged in full-time work (e.g., active duty) -> No.

4.  **Confirm the best fit:** Sense 6, "exerting influence or producing a change or effect," perfectly describes the function of a cytotoxic medicine or an "active substance" (i.e., the active ingredient).

5.  **Final Answer Formulation:** Return only the number 6.


[User]
Which numbered sense of "substance" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites.

Senses:
1. definition=the real physical matter of which a person or thing consists | examples=DNA is the substance of our genes
2. definition=the choicest or most essential or most vital part of some idea or experience | examples=the gist of the prosecutor's argument
3. definition=the idea that is intended | examples=What is the meaning of this proverb?
4. definition=material of a particular kind or constitution | examples=the immune response recognizes invading substances
5. definition=considerable capital (wealth or income) | examples=he is a man of means
6. definition=what a communication that is about something is about
7. definition=a particular kind or species of matter with uniform properties | examples=shigella is one of the most toxic substances known to man

reasoning_content:
1.  **Analyze the target word and context:** The word is "substance," and the context is: "The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine... which belongs to the group antimetabolites."

2.  **Determine the meaning of "substance" in this context:**
    *   Alimta/pemetrexed is a chemical compound (a drug).
    *   It is described as an "active" component.
    *   It is classified as a "cytotoxic medicine" and belongs to the group "antimetabolites."
    *   This refers to the chemical nature or composition of the drug itself.

3.  **Evaluate the provided senses against the determined meaning:**

    *   **1. definition=the real physical matter of which a person or thing consists | examples=DNA is the substance of our genes.** (Relates to fundamental composition/matter. Plausible, but maybe too broad.)
    *   **2. definition=the choicest or most essential or most vital part of some idea or experience | examples=the gist of the prosecutor's argument.** (Refers to essence/idea, not chemical matter. Incorrect.)
    *   **3. definition=the idea that is intended | examples=What is the meaning of this proverb?** (Refers to intent/meaning. Incorrect.)
    *   **4. definition=material of a particular kind or constitution | examples=the immune response recognizes invading substances.** (Refers to material/composition, often used in scientific/biological contexts. Very strong candidate.)
    *   **5. definition=considerable capital (wealth or income) | examples=he is a man of means.** (Refers to money/wealth. Incorrect.)
    *   **6. definition=what a communication that is about something is about.** (Refers to topic/subject matter. Incorrect.)
    *   **7. definition=a particular kind or species of matter with uniform properties | examples=shigella is one of the most toxic substances known to man.** (Refers to a specific type of matter/chemical entity. Extremely strong candidate, especially given the chemical/pharmacological context.)

4.  **Compare the strongest candidates (4 and 7):**

    *   Sense 4: "material of a particular kind or constitution." (General chemical/material description.)
    *   Sense 7: "a particular kind or species of matter with uniform properties." (Specific chemical/scientific description, emphasizing uniformity and classification.)

    The context ("Alimta, pemetrexed," "cytotoxic medicine," "antimetabolites") is highly specific to chemistry and pharmacology. Sense 7, which defines a substance as a specific type of matter with uniform properties, perfectly captures the scientific classification of a drug compound. Sense 4 is also relevant, but Sense 7 is the most precise fit for classifying a chemical entity like a drug.

5.  **Conclusion:** Sense 7 is the most accurate fit.


[User]
Which numbered sense of "medicine" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites.

Senses:
1. definition=the branches of medical science that deal with nonsurgical techniques
2. definition=(medicine) something that treats or prevents or alleviates the symptoms of disease
3. definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | examples=he studied medicine at Harvard
4. definition=punishment for one's actions | examples=you have to face the music

reasoning_content:
1.  **Analyze the request:** The user wants to identify which numbered sense of the word "medicine" is used in the provided sentence. The output must be only the number.

2.  **Analyze the sentence:** "The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites."

3.  **Analyze the context of "medicine" in the sentence:**
    *   Pemetrexed is an active substance.
    *   It is described as "cytotoxic."
    *   The parenthetical explanation clarifies: "(a medicine that kills cells that are dividing, such as cancer cells)."
    *   This usage refers to a *substance* or *drug* that has a therapeutic (or cytotoxic) effect on disease/cells.

4.  **Analyze the provided senses:**
    *   **Sense 1:** "the branches of medical science that deal with nonsurgical techniques." (Refers to a field of study/practice, e.g., internal medicine). *Does not fit.*
    *   **Sense 2:** "(medicine) something that treats or prevents or alleviates the symptoms of disease." (Refers to a drug/substance). *Fits perfectly.* Pemetrexed is a substance that treats cancer (by killing dividing cells).
    *   **Sense 3:** "the learned profession that is mastered by graduate training in a medical school..." (Refers to the profession/study, e.g., "He studied medicine"). *Does not fit.*
    *   **Sense 4:** "punishment for one's actions." (Refers to penalty). *Does not fit.*

5.  **Conclusion:** Sense 2 is the correct usage.

6.  **Format the output:** Return only the number.


[User]
Which numbered sense of "medicine" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites.

Senses:
1. definition=the branches of medical science that deal with nonsurgical techniques
2. definition=(medicine) something that treats or prevents or alleviates the symptoms of disease
3. definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | examples=he studied medicine at Harvard
4. definition=punishment for one's actions | examples=you have to face the music

reasoning_content:
1.  **Analyze the request:** The user wants to identify which numbered sense of the word "medicine" is used in the provided sentence. The output must be *only* the number.

2.  **Analyze the sentence:** "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites."

3.  **Analyze the context of "medicine" in the sentence:**
    *   Pemetrexed is an active substance.
    *   It is described as a "cytotoxic medicine."
    *   The parenthetical explanation clarifies what this "medicine" is: "a medicine that kills cells that are dividing, such as cancer cells."
    *   Pemetrexed is an antimetabolite (a type of drug/chemical).

4.  **Evaluate the senses:**
    *   **Sense 1:** "the branches of medical science that deal with nonsurgical techniques." (Refers to the field/discipline, e.g., internal medicine). *Does not fit.*
    *   **Sense 2:** "(medicine) something that treats or prevents or alleviates the symptoms of disease." (Refers to a substance/drug). *Fits perfectly.* Pemetrexed is a substance used to treat cancer (a disease).
    *   **Sense 3:** "the learned profession that is mastered by graduate training in a medical school..." (Refers to the profession/study, e.g., "He studied medicine"). *Does not fit.*
    *   **Sense 4:** "punishment for one's actions." (Refers to penalty). *Does not fit.*

5.  **Conclusion:** Sense 2 is the correct sense.

6.  **Format the output:** Return only the number.


[User]
Which numbered sense of "kill" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells), which belongs to the group antimetabolites.

Senses:
1. definition=cause to die; put to death, usually intentionally or knowingly | examples=This man killed several people when he tried to rob a bank
2. definition=thwart the passage of | examples=kill a motion
3. definition=end or extinguish by forceful means | examples=Stamp out poverty!
4. definition=be fatal | examples=cigarettes kill
5. definition=be the source of great pain for | examples=These new shoes are killing me!
6. definition=overwhelm with hilarity, pleasure, or admiration | examples=The comedian was so funny, he was killing me!
7. definition=hit with so much force as to make a return impossible, in racket games | examples=She killed the ball
8. definition=hit with great force | examples=He killed the ball
9. definition=deprive of life | examples=AIDS has killed thousands in Africa
10. definition=cause the death of, without intention | examples=She was killed in the collision of three cars
11. definition=drink down entirely | examples=He downed three martinis before dinner
12. definition=mark for deletion, rub off, or erase | examples=kill these lines in the President's speech
13. definition=tire out completely | examples=The daily stress of her work is killing her
14. definition=cause to cease operating | examples=kill the engine
15. definition=destroy a vitally essential quality of or in | examples=Eating artichokes kills the taste of all other foods

reasoning_content:
1.  **Analyze the sentence:** "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells), which belongs to the group antimetabolites."
2.  **Identify the context of "kills":** The verb "kills" is used in the phrase "a medicine that kills cells that are dividing."
3.  **Determine the meaning of "kills" in this context:** The medicine is causing the cells to die.
4.  **Examine the provided senses:**
    *   1. cause to die; put to death, usually intentionally or knowingly (Examples: killing people). *Fits the general idea of causing death.*
    *   2. thwart the passage of (Examples: kill a motion). *Incorrect.*
    *   3. end or extinguish by forceful means (Examples: Stamp out poverty!). *Incorrect.*
    *   4. be fatal (Examples: cigarettes kill). *This is a state of being, not an action performed by the medicine on the cells, though related.*
    *   5. be the source of great pain for (Examples: These new shoes are killing me!). *Incorrect.*
    *   6. overwhelm with hilarity, pleasure, or admiration (Examples: he was killing me!). *Incorrect.*
    *   7. hit with so much force as to make a return impossible, in racket games (Examples: She killed the ball). *Incorrect.*
    *   8. hit with great force (Examples: He killed the ball). *Incorrect.*
    *   9. deprive of life (Examples: AIDS has killed thousands in Africa). *This is a very strong match. The medicine deprives the cells of life.*
    *   10. cause the death of, without intention (Examples: She was killed in the collision...). *This implies an accidental death of a person, not the intended action of a cytotoxic drug.*
    *   11. drink down entirely (Examples: He downed three martinis...). *Incorrect.*
    *   12. mark for deletion, rub off, or erase (Examples: kill these lines...). *Incorrect.*
    *   13. tire out completely (Examples: The daily stress... is killing her). *Incorrect.*
    *   14. cause to cease operating (Examples: kill the engine). *Possible, but "deprive of life" (9) is more precise for biological cells.*
    *   15. destroy a vitally essential quality of or in (Examples: Eating artichokes kills the taste...). *This is about destroying a quality, not causing biological death.*

5.  **Compare the best candidates (1, 9, 10):**
    *   The medicine *causes* the cells to die.
    *   Sense 1: "cause to die; put to death, usually intentionally or knowingly." (The medicine is intentionally designed to do this.)
    *   Sense 9: "deprive of life." (This is the most precise biological description of what a cytotoxic agent does to a cell.)
    *   Sense 10: "cause the death of, without intention." (Incorrect, the drug is intended to kill the cancer cells.)

6.  **Select the most accurate sense:** While Sense 1 is technically correct, Sense 9 ("deprive of life") is the most precise and technical definition for a cytotoxic agent acting on cells. However, let's re-evaluate the provided examples and definitions to see if one is a better fit for the general usage.

    *   Sense 1: "cause to die; put to death, usually intentionally or knowingly." (The drug is intentionally designed to cause the death of cancer cells.)
    *   Sense 9: "deprive of life." (This is a perfect synonym for causing death in a biological context.)

    Since both 1 and 9 are very close, I must choose the one that best captures the action of a cytotoxic agent. "Deprive of life" (9) is the most specific biological term for this action.

7.  **Final check:** The medicine kills cells by depriving them of the ability to live/divide. Sense 9 is the best fit.


[User]
Which numbered sense of "cell" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells), which belongs to the group antimetabolites.

Senses:
1. definition=any small compartment | examples=the cells of a honeycomb
2. definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. definition=a device that delivers an electric current as the result of a chemical reaction
4. definition=a small unit serving as part of or as the nucleus of a larger political movement
5. definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver
6. definition=small room in which a monk or nun lives
7. definition=a room where a prisoner is kept

reasoning_content:
1.  **Analyze the request:** The user wants to identify which numbered sense of the word "cells" (marked with `<t>cells</t>`) is used in the provided sentence. The output must be only the number.

2.  **Analyze the sentence:** "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells), which belongs to the group antimetabolites."

3.  **Analyze the context of "cells":**
    *   The context is "cytotoxic medicine" and "antimetabolites."
    *   The target of the medicine is "cells that are dividing," specifically "cancer cells."
    *   This clearly relates to biological units of life.

4.  **Evaluate the senses:**
    *   1. definition=any small compartment | examples=the cells of a honeycomb (Incorrect - not about biological units.)
    *   2. definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life... (Correct - this is the definition of biological cells, matching "cancer cells" and "cytotoxic medicine.")
    *   3. definition=a device that delivers an electric current... (Incorrect - technical/electrical.)
    *   4. definition=a small unit serving as part of or as the nucleus of a larger political movement (Incorrect - political.)
    *   5. definition=a hand-held mobile radiotelephone... (Incorrect - technology/telecom.)
    *   6. definition=small room in which a monk or nun lives (Incorrect - architectural/religious.)
    *   7. definition=a room where a prisoner is kept (Incorrect - architectural/legal.)

5.  **Conclusion:** Sense 2 is the correct sense.

6.  **Format the output:** Return only the number.


[User]
Which numbered sense of "divide" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells), which belongs to the group antimetabolites.

Senses:
1. definition=separate into parts or portions | examples=divide the cake into three equal parts
2. definition=perform a division | examples=Can you divide 49 by seven?
3. definition=act as a barrier between; stand between | examples=The mountain range divides the two countries
4. definition=come apart | examples=The two pieces that we had glued separated
5. definition=make a division or separation
6. definition=force, take, or pull apart | examples=He separated the fighting children

reasoning_content:
1.  **Analyze the request:** The user wants to identify which numbered sense of the word "divide" (specifically, the form "dividing") is used in the provided sentence. The output must be only the number.

2.  **Analyze the sentence:** "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells), which belongs to the group antimetabolites."

3.  **Analyze the context of "dividing":** The word "dividing" modifies "cells." The cells are being killed because they are in the process of dividing.

4.  **Evaluate the senses of "divide":**

    *   1. definition=separate into parts or portions | examples=divide the cake into three equal parts (This relates to physical separation/splitting.)
    *   2. definition=perform a division | examples=Can you divide 49 by seven? (This relates to mathematical operation.)
    *   3. definition=act as a barrier between; stand between | examples=The mountain range divides the two countries (This relates to spatial separation/partitioning.)
    *   4. definition=come apart | examples=The two pieces that we had glued separated (This is intransitive, meaning the object separates itself.)
    *   5. definition=make a division or separation (This is a general sense, often related to the process of splitting or separating.)
    *   6. definition=force, take, or pull apart | examples=He separated the fighting children (This relates to forceful physical separation.)

5.  **Match the context to the senses:**
    *   When cells are "dividing," they are undergoing cell division (mitosis or meiosis). This process involves the cell splitting into two or more daughter cells.
    *   This process is fundamentally about separating into parts or portions.

6.  **Select the best fit:**
    *   Sense 1 ("separate into parts or portions") perfectly describes cell division.
    *   Sense 5 ("make a division or separation") is also plausible, but Sense 1 is more specific to the biological action described.

7.  **Final check:** "Cells that are dividing" means cells that are splitting into two. This matches Sense 1.

8.  **Format the output:** Return only the number. (1)


[User]
Which numbered sense of "body" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=the entire structure of an organism (an animal, plant, or human being) | examples=he felt as if his whole body were on fire
2. definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium
3. definition=a natural object consisting of a dead animal or person | examples=they found the body in the lake
4. definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. definition=the body excluding the head and neck and limbs | examples=they moved their arms and legs and bodies
6. definition=a collection of particulars considered as a system | examples=a body of law
7. definition=the property of holding together and retaining its shape | examples=wool has more body than rayon
8. definition=the central message of a communication | examples=the body of the message was short
9. definition=the main mass of a thing
10. definition=a resonating chamber in a musical instrument (as the body of a violin)
11. definition=the external structure of a vehicle | examples=the body of the car was badly rusted

reasoning_content:
1.  **Analyze the sentence:** "In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."
2.  **Identify the context of "body":** The sentence discusses a chemical process (conversion of pemetrexed) happening within a biological system (enzymes, nucleotides, DNA, RNA, cells).
3.  **Determine the meaning of "body" in this context:** It refers to the physical structure of the organism (the human or cellular body) where the drug is metabolized.
4.  **Examine the provided senses:**
    *   1. definition=the entire structure of an organism (an animal, plant, or human being) | examples=he felt as if his whole body were on fire
    *   2. definition=a group of persons...
    *   3. definition=a natural object consisting of a dead animal or person
    *   4. definition=an individual 3-dimensional object that has mass...
    *   5. definition=the body excluding the head and neck and limbs
    *   6. definition=a collection of particulars considered as a system
    *   7. definition=the property of holding together and retaining its shape
    *   8. definition=the central message of a communication
    *   9. definition=the main mass of a thing
    *   10. definition=a resonating chamber in a musical instrument
    *   11. definition=the external structure of a vehicle
5.  **Match the meaning to the senses:** The meaning (the entire structure of an organism) perfectly matches Sense 1.
6.  **Select the corresponding number:** 1.


[User]
Which numbered sense of "convert" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=change from one system to another or to a new plan or policy | examples=We converted from 220 to 110 Volt
2. definition=change the nature, purpose, or function of something | examples=convert lead into gold
3. definition=change religious beliefs, or adopt a religious belief | examples=She converted to Buddhism
4. definition=exchange or replace with another, usually of the same kind or category | examples=Could you convert my dollars into pounds?
5. definition=cause to adopt a new or different faith | examples=The missionaries converted the Indian population
6. definition=score an extra point or points after touchdown by kicking the ball through the uprights or advancing the ball into the end zone | examples=Smith converted and his team won
7. definition=complete successfully | examples=score a penalty shot or free throw
8. definition=score (a spare)
9. definition=make (someone) agree, understand, or realize the truth or validity of something | examples=He had finally convinced several customers of the advantages of his product
10. definition=exchange a penalty for a less severe one
11. definition=change in nature, purpose, or function; undergo a chemical change | examples=The substance converts to an acid

reasoning_content:
1.  **Analyze the sentence:** "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes..."
2.  **Identify the core action:** The drug (pemetrexed) is changing its state/form (being converted) into a different, active form.
3.  **Analyze the context:** The context is biological/chemical (drug metabolism, active form, enzymes, nucleotides, DNA, RNA).
4.  **Examine the senses of "convert":**
    *   1. System/plan change (Electrical voltage). (No)
    *   2. Change nature/purpose/function (Lead into gold). (Possible, but usually implies a fundamental change in identity, not just chemical transformation.)
    *   3. Change religious beliefs. (No)
    *   4. Exchange/replace (Dollars into pounds). (No)
    *   5. Cause to adopt a new faith. (No)
    *   6. Score extra point (Sports). (No)
    *   7. Complete successfully (Score a penalty). (No)
    *   8. Score a spare (Bowling). (No)
    *   9. Make someone agree/realize. (No)
    *   10. Exchange penalty. (No)
    *   11. Change in nature, purpose, or function; undergo a chemical change (The substance converts to an acid). (This perfectly matches the biological/chemical transformation described: pemetrexed -> active form.)
5.  **Select the best fit:** Sense 11 describes a chemical transformation, which is exactly what happens when a drug is metabolized into an active form in the body.

6.  **Final check:** The sentence describes a chemical change (pemetrexed to active form). Sense 11 is "undergo a chemical change." This is the correct sense.


[User]
Which numbered sense of "active" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. definition=engaged in or ready for military or naval operations | examples=on active duty
3. definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations
4. definition=taking part in an activity | examples=an active member of the club
5. definition=characterized by energetic activity | examples=an active toddler
6. definition=exerting influence or producing a change or effect | examples=an active ingredient
7. definition=full of activity or engaged in continuous activity | examples=an active seaport
8. definition=in operation | examples=keep hope alive
9. definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being
12. definition=(of e.g. volcanos) capable of erupting
13. definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. definition=engaged in full-time work | examples=active duty

reasoning_content:
1.  **Analyze the target word and context:** The word is "active" in the sentence: "In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes..."

2.  **Determine the meaning of "active" in this context:**
    *   Pemetrexed is a drug.
    *   It is converted into a form that *blocks* enzymes.
    *   In pharmacology, an "active form" means the form that performs the intended biological function (i.e., the form that has a chemical effect).

3.  **Evaluate the provided senses against the determined meaning:**

    *   1. tending to become more severe or wider in scope (e.g., active tuberculosis) -> *Not applicable.*
    *   2. engaged in or ready for military or naval operations (e.g., on active duty) -> *Not applicable.*
    *   3. disposed to take action or effectuate change (e.g., a director who takes an active interest) -> *Possible, but too general. It relates to capability/effect.*
    *   4. taking part in an activity (e.g., an active member of the club) -> *Not applicable (it's a chemical state, not participation).*
    *   5. characterized by energetic activity (e.g., an active toddler) -> *Not applicable (it's a chemical state, not physical energy).*
    *   6. exerting influence or producing a change or effect (e.g., an active ingredient) -> *This fits perfectly. The "active form" is the ingredient/molecule that exerts the biological effect (blocking enzymes).*
    *   7. full of activity or engaged in continuous activity (e.g., an active seaport) -> *Not applicable.*
    *   8. in operation (e.g., keep hope alive) -> *Not applicable (though related to function, sense 6 is more precise for chemical function).*
    *   9. (of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions -> *Not applicable.*
    *   10. expressing that the subject of the sentence has the semantic function of actor -> *Grammatical/Linguistic sense, not the meaning of the adjective.*
    *   11. (used of verbs... and participial adjectives...) expressing action rather than a state of being -> *Grammatical/Linguistic sense, not the meaning of the adjective.*
    *   12. (of e.g. volcanos) capable of erupting -> *Not applicable.*
    *   13. (of e.g. volcanos) erupting or liable to erupt (e.g., active volcanos) -> *Not applicable.*
    *   14. engaged in full-time work (e.g., active duty) -> *Not applicable.*

4.  **Conclusion:** Sense 6 ("exerting influence or producing a change or effect") is the correct sense, as the "active form" is the biologically effective ingredient.

5.  **Final Output Generation:** Return only the number 6.


[User]
Which numbered sense of "form" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=the phonological or orthographic sound or appearance of a word that can be used to describe or identify something | examples=the inflected forms of a word can be represented by a stem and a list of inflections to be attached
2. definition=a category of things distinguished by some common characteristic or quality | examples=sculpture is a form of art
3. definition=a perceptual structure | examples=the composition presents problems for students of musical form
4. definition=any spatial attributes (especially as defined by outline) | examples=he could barely make out their shapes
5. definition=alternative names for the body of a human being | examples=Leonardo studied the human body
6. definition=the spatial arrangement of something as distinct from its substance | examples=geometry is the mathematical science of shape
7. definition=the visual appearance of something or someone | examples=the delicate cast of his features
8. definition=a printed document with spaces in which to write | examples=he filled out his tax form
9. definition=(biology) a group of organisms within a species that differ in trivial ways from similar groups | examples=a new strain of microorganisms
10. definition=an arrangement of the elements in a composition or discourse | examples=the essay was in the form of a dialogue
11. definition=a particular mode in which something is manifested | examples=his resentment took the form of extreme hostility
12. definition=(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary | examples=the reaction occurs in the liquid phase of the system
13. definition=a body of students who are taught together | examples=early morning classes are always sleepy
14. definition=an ability to perform well | examples=he was at the top of his form
15. definition=a life-size dummy used to display clothes
16. definition=a mold for setting concrete | examples=they built elaborate forms for pouring the foundation

reasoning_content:
1.  **Analyze the sentence:** "In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."
2.  **Identify the target word:** "form".
3.  **Determine the context:** The context is biological/chemical. Pemetrexed (a drug) is converted into an "active form." This implies a change in the substance's state or structure that makes it biologically effective.
4.  **Evaluate the senses provided:**
    *   1. Phonological/orthographic sound (No).
    *   2. Category of things (No, it's a specific state/type of the substance).
    *   3. Perceptual structure (No, not about perception).
    *   4. Spatial attributes/outline (No, not about shape in space).
    *   5. Alternative names for the human body (No).
    *   6. Spatial arrangement/shape (No, not about geometry).
    *   7. Visual appearance (No).
    *   8. Printed document (No).
    *   9. Group of organisms (No).
    *   10. Arrangement of elements in discourse (No).
    *   11. A particular mode in which something is manifested (Possible, but usually refers to how an abstract concept appears, e.g., "resentment took the form of hostility").
    *   12. (Physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary (Highly relevant. Chemical conversion often results in a new chemical state or compound/form).
    *   13. Group of students (No).
    *   14. Ability to perform well (No).
    *   15. Dummy for clothes (No).
    *   16. Mold for concrete (No).
5.  **Compare the context to the best fit:** The conversion of a drug (pemetrexed) into an "active form" strongly suggests a change in its chemical state or structure, making sense 12 (a distinct state of matter/chemical state) the most accurate fit, especially given the biological/chemical context. While "form" can sometimes mean "type" (like sense 2), sense 12 specifically addresses the chemical/physical change implied by "converted into an active form" in a scientific text.

6.  **Conclusion:** Sense 12 is the correct fit.


[User]
Which numbered sense of "block" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the body, pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=render unsuitable for passage | examples=block the way
2. definition=hinder or prevent the progress or accomplishment of | examples=His brother blocked him at every turn
3. definition=stop from happening or developing | examples=Block his election
4. definition=interfere with or prevent the reception of signals | examples=Jam the Voice of America
5. definition=run on a block system | examples=block trains
6. definition=interrupt the normal function of by means of anesthesia | examples=block a nerve
7. definition=shut out from view or get in the way so as to hide from sight | examples=The thick curtain blocked the action on the stage
8. definition=stamp or emboss a title or design on a book with a block | examples=block the book cover
9. definition=obstruct | examples=My nose is all stuffed
10. definition=block passage through | examples=obstruct the path
11. definition=support, secure, or raise with a block | examples=block a plate for printing
12. definition=impede the movement of (an opponent or a ball) | examples=block an attack
13. definition=be unable to remember | examples=I'm drawing a blank
14. definition=shape by using a block | examples=Block a hat
15. definition=shape into a block or blocks | examples=block the graphs so one can see the results clearly
16. definition=prohibit the conversion or use of (assets) | examples=Blocked funds

reasoning_content:
1.  **Analyze the sentence:** "In the body, pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides..."
2.  **Identify the context:** The context is biological/chemical (drugs, enzymes, nucleotides, DNA/RNA).
3.  **Determine the meaning of "blocks" in this context:** The active form of pemetrexed is stopping or inhibiting the function (activity) of specific enzymes.
4.  **Examine the senses provided:**
    *   1. render unsuitable for passage (Physical obstruction) - No.
    *   2. hinder or prevent the progress or accomplishment of (General prevention/impediment) - Plausible.
    *   3. stop from happening or developing (Cessation of process) - Plausible.
    *   4. interfere with or prevent the reception of signals (Signal interference) - Too specific (radio/electronics).
    *   5. run on a block system (System/Logistics) - No.
    *   6. interrupt the normal function of by means of anesthesia (Biological/Medical inhibition) - Highly specific and relevant to enzyme activity.
    *   7. shut out from view (Visual obstruction) - No.
    *   8. stamp or emboss (Printing/Design) - No.
    *   9. obstruct (General physical obstruction) - Less precise than biological inhibition.
    *   10. block passage through (Physical obstruction) - No.
    *   11. support, secure, or raise (Construction) - No.
    *   12. impede the movement of (Physical movement) - Less precise than biological inhibition.
    *   13. be unable to remember (Cognitive) - No.
    *   14. shape by using a block (Sculpting) - No.
    *   15. shape into a block or blocks (Sculpting) - No.
    *   16. prohibit the conversion or use of (Financial/Legal) - No.
5.  **Compare the most relevant senses (2, 3, 6):**
    *   Sense 2: "hinder or prevent the progress or accomplishment of." (General inhibition)
    *   Sense 3: "stop from happening or developing." (General cessation)
    *   Sense 6: "interrupt the normal function of by means of anesthesia." (Specific biological/pharmacological inhibition)
6.  **Select the best fit:** Since the sentence specifically refers to inhibiting the *activity of enzymes* (a biological function), Sense 6, which deals with interrupting normal function in a biological/medical context, is the most precise and accurate definition. While Sense 2 is technically correct, Sense 6 captures the specialized meaning used in pharmacology/biology.

7.  **Final check:** The drug "blocks the activity of the enzymes." This is a classic example of enzyme inhibition, which aligns perfectly with Sense 6.


[User]
Which numbered sense of "involved" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved
2. definition=entangled or hindered as if e.g. in mire | examples=the difficulties in which the question is involved
3. definition=emotionally involved
4. definition=highly complex or intricate and occasionally devious; ; ; ; ; ; ; ; - Sir Walter Scott | examples=the Byzantine tax structure
5. definition=enveloped | examples=a castle involved in mist

reasoning_content:
1.  **Analyze the sentence:** "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides..."
2.  **Identify the context of "involved":** The enzymes are "involved in producing nucleotides." This means the enzymes participate in or are part of the process of nucleotide production.
3.  **Analyze the senses provided:**
    *   1. definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved
    *   2. definition=entangled or hindered as if e.g. in mire | examples=the difficulties in which the question is involved
    *   3. definition=emotionally involved
    *   4. definition=highly complex or intricate and occasionally devious; | examples=the Byzantine tax structure
    *   5. definition=enveloped | examples=a castle involved in mist
4.  **Match the context to the senses:**
    *   The enzymes *participate* in the production process.
    *   Sense 1 ("connected by participation or association or use") perfectly matches this meaning.
    *   Sense 2 (entangled/hindered) does not fit.
    *   Sense 3 (emotionally) does not fit.
    *   Sense 4 (complex/intricate) does not fit.
    *   Sense 5 (enveloped) does not fit.
5.  **Conclusion:** The correct sense is 1.
6.  **Format the output:** Return only the number.


[User]
Which numbered sense of "produce" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in <t>producing</t> nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=bring forth or yield | examples=The tree would not produce fruit
2. definition=create or manufacture a man-made product | examples=We produce more cars than we can sell
3. definition=cause to happen, occur or exist | examples=This procedure produces a curious effect
4. definition=bring out for display | examples=The proud father produced many pictures of his baby
5. definition=cultivate by growing, often involving improvements by means of agricultural techniques | examples=The Bordeaux region produces great red wines
6. definition=bring onto the market or release | examples=produce a movie
7. definition=come to have or undergo a change of (physical features and attributes) | examples=He grew a beard

reasoning_content:
1.  **Analyze the sentence:** "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in <t>producing</t> nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."
2.  **Identify the word in question:** "producing" (the gerund/participle form of "produce").
3.  **Determine the context:** The context is biological/chemical. Enzymes are involved in the process of making nucleotides (building blocks of DNA/RNA).
4.  **Analyze the meaning of "producing" in this context:** It means the enzymes are causing or facilitating the creation/generation of nucleotides.
5.  **Evaluate the provided senses:**
    *   1. bring forth or yield (e.g., tree producing fruit). *Fits the idea of yielding a product.*
    *   2. create or manufacture a man-made product (e.g., producing cars). *Too specific (man-made).*
    *   3. cause to happen, occur or exist (e.g., procedure produces an effect). *Fits the idea of causing the nucleotides to exist/be formed.*
    *   4. bring out for display (e.g., producing pictures). *Incorrect.*
    *   5. cultivate by growing (e.g., Bordeaux producing wines). *Incorrect (agricultural).*
    *   6. bring onto the market or release (e.g., produce a movie). *Incorrect.*
    *   7. come to have or undergo a change (e.g., He grew a beard). *Incorrect (this is usually "grow," not "produce" in this sense).*
6.  **Compare the best fits (1 and 3):**
    *   Sense 1 (bring forth or yield): Enzymes yield nucleotides. This is accurate.
    *   Sense 3 (cause to happen, occur or exist): Enzymes cause the nucleotides to be formed/exist. This is also accurate.
7.  **Select the most precise fit for biological synthesis:** When enzymes are involved in synthesis, they are *causing* the formation of the product. Sense 3 ("cause to happen, occur or exist") is a very strong fit for biological processes of creation/synthesis. Sense 1 ("bring forth or yield") is also applicable, but Sense 3 captures the active role of the enzyme (the cause).

8.  **Re-evaluating the relationship between 1 and 3:**
    *   If the enzyme *yields* nucleotides (Sense 1), it is *causing* them to be formed (Sense 3).
    *   In the context of biological synthesis, "producing" means the process *results* in the formation of the product. Both 1 and 3 are plausible. However, Sense 3, "cause to happen, occur or exist," is the most general and accurate description of a chemical reaction leading to a new substance.

9.  **Final check:** The enzymes are *causing* the nucleotides to be *produced* (formed). Sense 3 is the best match.


[User]
Which numbered sense of "building_block" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the <t>building blocks</t> of DNA and RNA, the genetic material of cells).

Senses:
1. definition=a single undivided natural thing occurring in the composition of something else | examples=units of nucleic acids
2. definition=a block of material used in construction work

reasoning_content:
1.  **Analyze the request:** The user wants to identify which numbered sense of the word "building_block" (marked as `<t>building blocks</t>`) is used in the provided sentence. The output must be *only* the number.

2.  **Analyze the sentence context:** "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the <t>building blocks</t> of DNA and RNA, the genetic material of cells)."

3.  **Analyze the specific phrase:** "building blocks of DNA and RNA."

4.  **Analyze the candidates (Senses):**
    *   **Sense 1:** definition=a single undivided natural thing occurring in the composition of something else | examples=units of nucleic acids
    *   **Sense 2:** definition=a block of material used in construction work

5.  **Match the context to the senses:**
    *   The context refers to "nucleotides" which are the components of DNA and RNA.
    *   Sense 1 explicitly defines the concept as "units of nucleic acids" and describes them as "a single undivided natural thing occurring in the composition of something else." This is a perfect match.
    *   Sense 2 refers to physical construction materials (like bricks or wooden blocks), which is irrelevant to biological molecules (nucleotides).

6.  **Determine the correct number:** Sense 1 is the correct sense.

7.  **Format the output:** Return only the number.


[User]
Which numbered sense of "genetic" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the <t>genetic</t> material of cells).

Senses:
1. definition=occurring among members of a family usually by heredity | examples=an inherited disease
2. definition=of or relating to or produced by or being a gene | examples=genic combinations
3. definition=pertaining to or referring to origin | examples=genetic history reconstructs the origins of a literary work
4. definition=of or relating to the science of genetics | examples=genetic research

reasoning_content:
1.  **Analyze the request:** The user wants to identify which numbered sense of the word "genetic" is used in the provided sentence. The output must be only the number.

2.  **Analyze the sentence:** "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the <t>genetic</t> material of cells)."

3.  **Analyze the context of "genetic":** The word "genetic" modifies "material." The material is described as "the building blocks of DNA and RNA." DNA and RNA are the primary carriers of genetic information.

4.  **Evaluate the senses:**
    *   **Sense 1:** occurring among members of a family usually by heredity (e.g., inherited disease). *Does "material" refer to a family trait? No.*
    *   **Sense 2:** of or relating to or produced by or being a gene (e.g., genic combinations). *DNA/RNA are made of genes and carry genetic information. This fits perfectly.*
    *   **Sense 3:** pertaining to or referring to origin (e.g., genetic history reconstructs the origins...). *While DNA relates to origin, the primary meaning here is the *nature* of the material (being gene-based), not just its origin.*
    *   **Sense 4:** of or relating to the science of genetics (e.g., genetic research). *This refers to the field of study, not the material itself.*

5.  **Conclusion:** The phrase "genetic material" refers to the substance (DNA/RNA) that contains the genes. This aligns directly with Sense 2: "of or relating to or produced by or being a gene."

6.  **Final Output Generation:** Return only the number 2.


[User]
Which numbered sense of "material" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic <t>material</t> of cells).

Senses:
1. definition=the tangible substance that goes into the makeup of a physical object | examples=coal is a hard black material
2. definition=information (data or ideas or observations) that can be used or reworked into a finished form | examples=the archives provided rich material for a definitive biography
3. definition=artifact made by weaving or felting or knitting or crocheting natural or synthetic fibers | examples=the fabric in the curtains was light and semitransparent
4. definition=things needed for doing or making something | examples=writing materials
5. definition=a person judged suitable for admission or employment | examples=he was university material

reasoning_content:
1.  **Analyze the request:** The user wants to identify which numbered sense of the word "material" (marked with `<t>material</t>`) is used in the provided sentence. The output must be only the number.

2.  **Analyze the sentence and context:**
    *   Sentence: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic <t>material</t> of cells)."
    *   The phrase is "the genetic material of cells."
    *   "Genetic material" refers to DNA and RNA, which carry the instructions (information) for the cell.

3.  **Evaluate the senses of "material":**

    *   **Sense 1:** definition=the tangible substance that goes into the makeup of a physical object | examples=coal is a hard black material. (Focuses on physical substance/matter.)
    *   **Sense 2:** definition=information (data or ideas or observations) that can be used or reworked into a finished form | examples=the archives provided rich material for a definitive biography. (Focuses on information/data.)
    *   **Sense 3:** definition=artifact made by weaving or felting or knitting or crocheting natural or synthetic fibers | examples=the fabric in the curtains was light and semitransparent. (Focuses on textile/fiber.)
    *   **Sense 4:** definition=things needed for doing or making something | examples=writing materials. (Focuses on supplies/resources.)
    *   **Sense 5:** definition=a person judged suitable for admission or employment | examples=he was university material. (Focuses on suitability/person.)

4.  **Match the context to the sense:**
    *   "Genetic material" refers to the genetic code (DNA/RNA). This is fundamentally information.
    *   Sense 2 defines "material" as "information (data or ideas or observations) that can be used or reworked into a finished form."

5.  **Conclusion:** Sense 2 is the correct fit.

6.  **Format the output:** Return only the number.


[User]
Which numbered sense of "cell" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of <t>cells</t>).

Senses:
1. definition=any small compartment | examples=the cells of a honeycomb
2. definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. definition=a device that delivers an electric current as the result of a chemical reaction
4. definition=a small unit serving as part of or as the nucleus of a larger political movement
5. definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver
6. definition=small room in which a monk or nun lives
7. definition=a room where a prisoner is kept

reasoning_content:
1.  **Analyze the request:** The user wants to identify which numbered sense of the word "cells" (marked with `<t>cells</t>`) is used in the provided sentence. The output must be *only* the number.

2.  **Analyze the sentence context:** "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of <t>cells</t>)."

3.  **Determine the meaning of "cells" in context:** The sentence discusses DNA, RNA, nucleotides, enzymes, and the body. These are all biological concepts. "Cells" here refers to the fundamental units of life (biological cells).

4.  **Evaluate the provided senses:**
    *   1. any small compartment (e.g., honeycomb cells) - *Incorrect.*
    *   2. (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life... - *Correct.* This matches the biological context (DNA, RNA, body).
    *   3. a device that delivers an electric current (battery cell) - *Incorrect.*
    *   4. a small unit serving as part of or as the nucleus of a larger political movement - *Incorrect.*
    *   5. a hand-held mobile radiotelephone (cell phone) - *Incorrect.*
    *   6. small room in which a monk or nun lives (cell) - *Incorrect.*
    *   7. a room where a prisoner is kept (cell) - *Incorrect.*

5.  **Select the corresponding number:** Sense 2 is the correct meaning.

6.  **Format the output:** Return only the number.


[User]
Which numbered sense of "study" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: How has Alimta been <t>studied</t>?

Senses:
1. definition=consider in detail and subject to an analysis in order to discover essential features or meaning | examples=analyze a sonnet by Shakespeare
2. definition=be a student; follow a course of study; be enrolled at an institute of learning
3. definition=give careful consideration to | examples=consider the possibility of moving
4. definition=be a student of a certain subject | examples=She is reading for the bar exam
5. definition=learn by reading books | examples=He is studying geology in his room
6. definition=think intently and at length, as for spiritual purposes | examples=He is meditating in his study

reasoning_content:
1.  **Analyze the sentence:** "How has Alimta been studied?"
2.  **Identify the target word:** "studied" (past participle of "study").
3.  **Determine the grammatical role:** "studied" is part of the passive voice ("has been studied").
4.  **Analyze the meaning in context:** The sentence asks about the *manner* or *method* by which Alimta has been examined, analyzed, or researched. Alimta is the object of the action (the one being studied).
5.  **Evaluate the senses:**

    *   1. definition=consider in detail and subject to an analysis in order to discover essential features or meaning | examples=analyze a sonnet by Shakespeare. (This fits the idea of being analyzed or examined.)
    *   2. definition=be a student; follow a course of study; be enrolled at an institute of learning. (This is active/intransitive, meaning Alimta is the student. Incorrect.)
    *   3. definition=give careful consideration to | examples=consider the possibility of moving. (This is usually active, meaning someone is considering something. While related to analysis, Sense 1 is a much stronger fit for the action of *being* studied.)
    *   4. definition=be a student of a certain subject | examples=She is reading for the bar exam. (This is a state of being, not the action of being examined. Incorrect.)
    *   5. definition=learn by reading books | examples=He is studying geology in his room. (This is active, meaning Alimta is doing the studying. Incorrect.)
    *   6. definition=think intently and at length, as for spiritual purposes | examples=He is meditating in his study. (This is related to the noun "study" or the act of deep thought, not the passive action of being examined. Incorrect.)

6.  **Select the best fit:** Sense 1 ("consider in detail and subject to an analysis...") perfectly matches the meaning of being subjected to an examination or analysis.

7.  **Final Answer Formulation:** Return only the number.


[User]
Which numbered sense of "treatment" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: For the <t>treatment</t> of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before.

Senses:
1. definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)
2. definition=the management of someone or something | examples=the handling of prisoners
3. definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture
4. definition=an extended communication (often interactive) dealing with some particular topic | examples=the book contains an excellent discussion of modal logic

reasoning_content:
1.  **Analyze the request:** The user wants to identify which numbered sense of the word "treatment" (<t>treatment</t>) is used in the provided sentence. The output must be *only* the number.

2.  **Analyze the sentence:** "For the <t>treatment</t> of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before."

3.  **Determine the context of "treatment":** The context is "malignant pleural mesothelioma" (a disease) and "Alimta" (a drug/medical intervention). The sentence discusses how Alimta is used to manage or cure this disease.

4.  **Evaluate the senses:**
    *   **Sense 1:** definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury).
        *   *Match?* Yes. Medical care/procedures for a disease (mesothelioma) is the definition of medical treatment.
    *   **Sense 2:** definition=the management of someone or something | examples=the handling of prisoners.
        *   *Match?* Plausible, as medical care is a form of management, but Sense 1 is much more specific and accurate for the medical context.
    *   **Sense 3:** definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture.
        *   *Match?* No. This is an artistic/stylistic context.
    *   **Sense 4:** definition=an extended communication (often interactive) dealing with some particular topic | examples=the book contains an excellent discussion of modal logic.
        *   *Match?* No. This is a communication/discussion context.

5.  **Select the best fit:** Sense 1 ("care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)") is the precise meaning of "treatment" when referring to a medical intervention for a disease.

6.  **Final Output Generation:** Return only the number 1.


[User]
Which numbered sense of "study" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: For the treatment of malignant pleural mesothelioma, Alimta has been <t>studied</t> in one main study in 456 patients who had not received chemotherapy for their disease before.

Senses:
1. definition=consider in detail and subject to an analysis in order to discover essential features or meaning | examples=analyze a sonnet by Shakespeare
2. definition=be a student; follow a course of study; be enrolled at an institute of learning
3. definition=give careful consideration to | examples=consider the possibility of moving
4. definition=be a student of a certain subject | examples=She is reading for the bar exam
5. definition=learn by reading books | examples=He is studying geology in his room
6. definition=think intently and at length, as for spiritual purposes | examples=He is meditating in his study

reasoning_content:
1.  **Analyze the sentence:** "For the treatment of malignant pleural mesothelioma, Alimta has been <t>studied</t> in one main study in 456 patients who had not received chemotherapy for their disease before."
2.  **Identify the target word and context:** The word is "studied," and the context is a medical/scientific trial ("treatment of malignant pleural mesothelioma," "one main study," "456 patients").
3.  **Determine the meaning of "studied" in this context:** It means that the drug (Alimta) has been investigated, analyzed, and tested in a formal research setting (a clinical trial).
4.  **Evaluate the provided senses:**
    *   1. definition=consider in detail and subject to an analysis in order to discover essential features or meaning | examples=analyze a sonnet by Shakespeare. (This matches the idea of scientific investigation/analysis.)
    *   2. definition=be a student; follow a course of study; be enrolled at an institute of learning. (Incorrect - refers to people learning.)
    *   3. definition=give careful consideration to | examples=consider the possibility of moving. (Incorrect - refers to mental consideration, not scientific testing.)
    *   4. definition=be a student of a certain subject | examples=She is reading for the bar exam. (Incorrect - refers to people learning.)
    *   5. definition=learn by reading books | examples=He is studying geology in his room. (Incorrect - refers to self-education.)
    *   6. definition=think intently and at length, as for spiritual purposes | examples=He is meditating in his study. (Incorrect - refers to deep contemplation.)
5.  **Match the context to the best sense:** The context requires the meaning of "analyzed/investigated in detail," which corresponds to Sense 1.
6.  **Final check:** "Alimta has been studied in one main study" means "Alimta has been analyzed/tested in one main study." This aligns perfectly with Sense 1.
7.  **Return the number:** 1.


[User]
Which numbered sense of "main" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: For the treatment of malignant pleural mesothelioma, Alimta has been studied in one <t>main</t> study in 456 patients who had not received chemotherapy for their disease before.

Senses:
1. definition=most important element | examples=the chief aim of living
2. definition=(of a clause) capable of standing syntactically alone as a complete sentence | examples=the main (or independent) clause in a complex sentence has at least a subject and a verb
3. definition=of force; of the greatest possible intensity | examples=by main strength

reasoning_content:
1.  **Analyze the request:** The user wants to identify which numbered sense of the word "main" is used in the provided sentence. The output must be *only* the number.

2.  **Analyze the sentence:** "For the treatment of malignant pleural mesothelioma, Alimta has been studied in one <t>main</t> study in 456 patients who had not received chemotherapy for their disease before."

3.  **Analyze the context of "main":** "one main study". Here, "main" modifies "study." It is describing the *type* or *importance* of the study.

4.  **Analyze the senses provided:**
    *   Sense 1: definition=most important element | examples=the chief aim of living. (Relates to importance/chief element.)
    *   Sense 2: definition=(of a clause) capable of standing syntactically alone as a complete sentence | examples=the main (or independent) clause in a complex sentence has at least a subject and a verb. (Relates to grammar/syntax.)
    *   Sense 3: definition=of force; of the greatest possible intensity | examples=by main strength. (Relates to intensity/force.)

5.  **Match the context to the senses:**
    *   Is "main study" referring to a grammatical structure? No (Sense 2).
    *   Is "main study" referring to intensity/force? No (Sense 3).
    *   Is "main study" referring to the most important or chief study? Yes. The study being referenced is the primary, most significant, or chief study. This aligns with Sense 1 (most important element).

6.  **Conclusion:** Sense 1 is the correct sense.

7.  **Format the output:** Return only the number.


[User]
Which numbered sense of "study" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main <t>study</t> in 456 patients who had not received chemotherapy for their disease before.

Senses:
1. definition=a detailed critical inspection
2. definition=applying the mind to learning and understanding a subject (especially by reading) | examples=mastering a second language requires a lot of work
3. definition=a written document describing the findings of some individual or group | examples=this accords with the recent study by Hill and Dale
4. definition=a state of deep mental absorption | examples=she is in a deep study
5. definition=a room used for reading and writing and studying | examples=he knocked lightly on the closed door of the study
6. definition=a branch of knowledge | examples=in what discipline is his doctorate?
7. definition=preliminary drawing for later elaboration | examples=he made several studies before starting to paint
8. definition=attentive consideration and meditation | examples=after much cogitation he rejected the offer
9. definition=someone who memorizes quickly and easily (as the lines for a part in a play) | examples=he is a quick study
10. definition=a composition intended to develop one aspect of the performer's technique | examples=a study in spiccato bowing

reasoning_content:
1.  **Analyze the sentence:** "For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main <t>study</t> in 456 patients who had not received chemotherapy for their disease before."
2.  **Identify the target word:** "study" (in the context of the sentence).
3.  **Determine the meaning of "study" in the sentence:** The sentence refers to a piece of research or an investigation conducted on a group of patients (456 patients) regarding the effectiveness of Alimta.
4.  **Examine the provided senses:**
    *   1. a detailed critical inspection (Possible, but usually refers to the *act* of inspecting, not the resulting document/trial.)
    *   2. applying the mind to learning and understanding a subject (Incorrect - this is the verb sense.)
    *   3. a written document describing the findings of some individual or group | examples=this accords with the recent study by Hill and Dale (This perfectly matches a clinical trial or research paper.)
    *   4. a state of deep mental absorption (Incorrect - abstract noun.)
    *   5. a room used for reading and writing and studying (Incorrect - place.)
    *   6. a branch of knowledge (Incorrect - field of science.)
    *   7. preliminary drawing for later elaboration (Incorrect - art/design.)
    *   8. attentive consideration and meditation (Incorrect - abstract noun/act.)
    *   9. someone who memorizes quickly and easily (Incorrect - person.)
    *   10. a composition intended to develop one aspect of the performer's technique (Incorrect - music/art.)
5.  **Match the meaning to the best sense:** The context (medical treatment, patients, research) strongly points to a formal piece of research or clinical trial. Sense 3 ("a written document describing the findings of some individual or group") is the correct fit.
6.  **Formulate the final answer:** Return only the number 3.


[User]
Which numbered sense of "patient" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 <t>patients</t> who had not received chemotherapy for their disease before.

Senses:
1. definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause

reasoning_content:
1.  **Analyze the Request:** The user wants to identify which numbered sense of the word "patients" (marked with `<t>`) is used in the provided sentence. The output must be *only* the number.

2.  **Analyze the Sentence:** "For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 <t>patients</t> who had not received chemotherapy for their disease before."

3.  **Analyze the Context of "patients":**
    *   The word refers to 456 individuals.
    *   These individuals are receiving (or are the subject of a study regarding) "treatment of malignant pleural mesothelioma."
    *   They are involved in a medical study/treatment process.

4.  **Analyze the Senses:**
    *   **Sense 1:** `definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly`
    *   **Sense 2:** `definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause` (This is a highly technical, abstract definition, likely referring to the grammatical/semantic role of a patient/theme/experiencer, not the concrete meaning of the noun itself.)

5.  **Match the Context to the Senses:**
    *   The individuals (patients) are people requiring medical care (treatment for mesothelioma). This perfectly matches the definition of **Sense 1**.
    *   Sense 2 describes a *role* (like 'theme' or 'experiencer') and is too abstract for the concrete usage in the sentence.

6.  **Conclusion:** Sense 1 is the correct usage.

7.  **Format the Output:** Return only the number.


[User]
Which numbered sense of "before" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease <t>before</t>.

Senses:
1. definition=earlier in time; previously | examples=I had known her before
2. definition=at or in the front | examples=I see the lights of a town ahead

reasoning_content:
1.  **Analyze the request:** The user wants to identify which numbered sense of the word "before" is used in the given sentence. The output must be only the number.

2.  **Analyze the sentence:** "For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease <t>before</t>."

3.  **Analyze the context of "before":** The phrase is "had not received chemotherapy for their disease before." This refers to a time point in the past relative to the study/treatment.

4.  **Analyze the senses provided:**
    *   Sense 1: definition=earlier in time; previously | examples=I had known her before
    *   Sense 2: definition=at or in the front | examples=I see the lights of a town ahead

5.  **Match the context to the senses:**
    *   The context ("had not received chemotherapy... before") clearly indicates a temporal relationship (earlier in time).
    *   Sense 1 matches this meaning ("earlier in time; previously").
    *   Sense 2 relates to spatial position ("at or in the front") and does not fit.

6.  **Determine the correct number:** The correct sense is 1.

7.  **Format the output:** Return only the number.


[User]
Which numbered sense of "effect" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: The <t>effects</t> of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Senses:
1. definition=a phenomenon that follows and is caused by some previous phenomenon | examples=the magnetic effect was greater when the rod was lengthwise
2. definition=an outward appearance | examples=he made a good impression
3. definition=an impression (especially one that is artificial or contrived) | examples=he just did it for effect
4. definition=the central meaning or theme of a speech or literary work
5. definition=(of a law) having legal validity | examples=the law is still in effect
6. definition=a symptom caused by an illness or a drug | examples=the effects of sleep loss

reasoning_content:
1.  **Analyze the sentence:** "The <t>effects</t> of Alimta in combination with cisplatin were compared with those of cisplatin alone."
2.  **Identify the key term:** "effects."
3.  **Determine the context:** The sentence discusses two substances (Alimta and cisplatin) and compares their "effects." Since Alimta and cisplatin are drugs/chemicals, their "effects" must refer to how they act on the body or the outcome of their use.
4.  **Evaluate the senses:**
    *   1. a phenomenon that follows and is caused by some previous phenomenon (Causality/Result). *This fits the context of drugs causing biological changes.*
    *   2. an outward appearance (Appearance). *Does not fit.*
    *   3. an impression (Artificial/Contrived). *Does not fit.*
    *   4. the central meaning or theme (Theme). *Does not fit.*
    *   5. having legal validity (Legal status). *Does not fit.*
    *   6. a symptom caused by an illness or a drug (Medical symptom/Result of drug). *This is a very specific type of result/phenomenon caused by a drug.*
5.  **Compare Senses 1 and 6:**
    *   Sense 1 is broad: "a phenomenon that follows and is caused by some previous phenomenon." (General scientific/causal result).
    *   Sense 6 is specific: "a symptom caused by an illness or a drug." (Medical/Pharmacological result).
6.  **Refine the choice:** Since the sentence explicitly mentions "Alimta" and "cisplatin" (drugs), the most precise and contextually appropriate meaning is the pharmacological result or symptom caused by the drug. Sense 6 captures this perfectly. While Sense 1 is technically correct (the drug causes a phenomenon), Sense 6 is the specialized meaning used in medical/scientific writing when discussing drug action.
7.  **Final selection:** Sense 6.