[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: contain
Target surface form: contains
Context:
It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the studies performed, to reach their recommendations on how to use the medicine. If you need more information about your medical condition or your treatment, read the Package Leaflet (also part of the EPAR) or contact your doctor or pharmacist. If you want more information on the basis of the CHMP recommendations, read the Scientific Discussion (also part of the EPAR). What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It <t>contains</t> the active substance pemetrexed. What is Alimta used for?

Candidate senses:
1. sense_key=contain%2:42:00:: | definition=include or contain; have as a component | synonyms=incorporate, comprise | examples=A totally new idea is comprised in this paper; The record contains many old songs from the 1930's
2. sense_key=contain%2:42:13:: | definition=contain or hold; have within | synonyms=hold, bear, carry | examples=The jar carries wine; The canteen holds fresh water
3. sense_key=contain%2:41:00:: | definition=lessen the intensity of; temper; hold in restraint; hold or keep within limits | synonyms=control, hold in, hold, check, curb, moderate | examples=moderate your alcohol intake; hold your tongue
4. sense_key=contain%2:42:06:: | definition=be divisible by | examples=24 contains 6
5. sense_key=contain%2:42:14:: | definition=be capable of holding or containing | synonyms=take, hold | examples=This box won't take all the items; The flask holds one gallon
6. sense_key=contain%2:33:00:: | definition=hold back, as of a danger or an enemy; check the expansion or influence of | synonyms=check, turn back, arrest, stop, hold back | examples=Arrest the downward trend; Check the growth of communism in South East Asia

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the word "contains" in the given context.

Context: "Alimta is a powder that is made up into a solution for infusion (drip into a vein). It <t>contains</t> the active substance pemetrexed."

Target word: contains

Candidate senses:
1. sense_key=contain%2:42:00:: | definition=include or contain; have as a component | synonyms=incorporate, comprise | examples=A totally new idea is comprised in this paper; The record contains many old songs from the 1930's
2. sense_key=contain%2:42:13:: | definition=contain or hold; have within | synonyms=hold, bear, carry | examples=The jar carries wine; The canteen holds fresh water
3. sense_key=contain%2:41:00:: | definition=lessen the intensity of; temper; hold in restraint; hold or keep within limits | synonyms=control, hold in, hold, check, curb, moderate | examples=moderate your alcohol intake; hold your tongue
4. sense_key=contain%2:42:06:: | definition=be divisible by | examples=24 contains 6
5. sense_key=contain%2:42:14:: | definition=be capable of holding or containing | synonyms=take, hold | examples=This box won't take all the items; The flask holds one gallon
6. sense_key=contain%2:33:00:: | definition=hold back, as of a danger or an enemy; check the expansion or influence of | synonyms=check, turn back, arrest, stop, hold back | examples=Arrest the downward trend; Check the growth of communism in South East Asia

Analysis:
The sentence states: "Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed."
Alimta (the solution) is a mixture, and pemetrexed is a component (the active substance) within that mixture.

Let's evaluate the senses:
1. sense_key=contain%2:42:00: Definition is "include or contain; have as a component". Synonyms: incorporate, comprise. This perfectly matches the idea of a substance being a component of a mixture.
2. sense_key=contain%2:42:13: Definition is "contain or hold; have within". This is general, but sense 1 is more specific to composition.
3. sense_key=contain%2:41:00: Definition relates to restraint/moderation. Irrelevant.
4. sense_key=contain%2:42:06: Definition relates to divisibility. Irrelevant.
5. sense_key=contain%2:42:14: Definition relates to capacity (being capable of holding). While related to physical containment, the focus here is on *what* is inside (the substance), not the capacity of the solution itself.
6. sense_key=contain%2:33:00: Definition relates to stopping/checking influence. Irrelevant.

Sense 1 ("include or contain; have as a component") is the most precise fit for describing a chemical substance (pemetrexed) being part of a pharmaceutical solution (Alimta).

The best sense is 1.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the studies performed, to reach their recommendations on how to use the medicine. If you need more information about your medical condition or your treatment, read the Package Leaflet (also part of the EPAR) or contact your doctor or pharmacist. If you want more information on the basis of the CHMP recommendations, read the Scientific Discussion (also part of the EPAR). What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the <t>active</t> substance pemetrexed. What is Alimta used for?

Candidate senses:
1. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
7. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
13. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

finish_reason: stop

role: assistant

reasoning_content:
1.  **Analyze the context:** The sentence is: "It contains the <t>active</t> substance pemetrexed."
2.  **Identify the target word and its role:** The target word is "active." It modifies "substance" (pemetrexed).
3.  **Determine the meaning required:** In the context of medicine/pharmaceuticals, an "active substance" refers to the component of a drug that produces the intended therapeutic effect.
4.  **Examine the candidate senses for relevance:**

    *   1. tending to become more severe or wider in scope (e.g., active tuberculosis) -> Not relevant.
    *   2. engaged in or ready for military or naval operations -> Not relevant.
    *   3. disposed to take action or effectuate change -> Possible, but too general.
    *   4. taking part in an activity -> Not relevant.
    *   5. characterized by energetic activity -> Not relevant (describes a person/animal).
    *   6. exerting influence or producing a change or effect (examples=an active ingredient) -> Highly relevant. This directly matches the concept of a drug's therapeutic component.
    *   7. full of activity or engaged in continuous activity -> Not relevant (describes a place/market).
    *   8. in operation -> Not relevant.
    *   9. (of the sun) characterized by an increased occurrence of sunspots and flares -> Not relevant.
    *   10. expressing that the subject of the sentence has the semantic function of actor -> Grammatical/linguistic sense, not relevant.
    *   11. expressing action rather than a state of being -> Grammatical/linguistic sense, not relevant.
    *   12. (of e.g. volcanos) capable of erupting -> Not relevant.
    *   13. (of e.g. volcanos) erupting or liable to erupt -> Not relevant.
    *   14. engaged in full-time work -> Not relevant.

5.  **Select the best fit:** Sense 6, "exerting influence or producing a change or effect," and its example "an active ingredient," is the precise meaning used when describing the component of a medicine that works.

6.  **Final check:** "Active substance pemetrexed" = "Substance that exerts influence/produces effect (pemetrexed)." This is correct.

currency: USD

source: unavailable


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: substance
Target surface form: substance
Context:
It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the studies performed, to reach their recommendations on how to use the medicine. If you need more information about your medical condition or your treatment, read the Package Leaflet (also part of the EPAR) or contact your doctor or pharmacist. If you want more information on the basis of the CHMP recommendations, read the Scientific Discussion (also part of the EPAR). What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active <t>substance</t> pemetrexed. What is Alimta used for?

Candidate senses:
1. sense_key=substance%1:03:00:: | definition=the real physical matter of which a person or thing consists | examples=DNA is the substance of our genes
2. sense_key=substance%1:09:01:: | definition=the choicest or most essential or most vital part of some idea or experience | synonyms=kernel, core, center, centre, essence, gist | examples=the gist of the prosecutor's argument; the heart and soul of the Republican Party
3. sense_key=substance%1:09:00:: | definition=the idea that is intended | synonyms=meaning | examples=What is the meaning of this proverb?
4. sense_key=substance%1:27:00:: | definition=material of a particular kind or constitution | examples=the immune response recognizes invading substances
5. sense_key=substance%1:21:00:: | definition=considerable capital (wealth or income) | synonyms=means | examples=he is a man of means
6. sense_key=substance%1:10:00:: | definition=what a communication that is about something is about | synonyms=message, content, subject matter
7. sense_key=substance%1:03:01:: | definition=a particular kind or species of matter with uniform properties | examples=shigella is one of the most toxic substances known to man

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "substance" in the given context.

Context: "Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active <t>substance</t> pemetrexed."

Target word: substance

Candidate senses:
1. sense_key=substance%1:03:00:: | definition=the real physical matter of which a person or thing consists | examples=DNA is the substance of our genes
2. sense_key=substance%1:09:01:: | definition=the choicest or most essential or most vital part of some idea or experience | synonyms=kernel, core, center, centre, essence, gist | examples=the gist of the prosecutor's argument; the heart and soul of the Republican Party
3. sense_key=substance%1:09:00:: | definition=the idea that is intended | synonyms=meaning | examples=What is the meaning of this proverb?
4. sense_key=substance%1:27:00:: | definition=material of a particular kind or constitution | examples=the immune response recognizes invading substances
5. sense_key=substance%1:21:00:: | definition=considerable capital (wealth or income) | synonyms=means | examples=he is a man of means
6. sense_key=substance%1:10:00:: | definition=what a communication that is about something is about | synonyms=message, content, subject matter
7. sense_key=substance%1:03:01:: | definition=a particular kind or species of matter with uniform properties | examples=shigella is one of the most toxic substances known to man

Analysis:
The context describes a medicine (Alimta), which is a powder/solution. It states that this medicine "contains the active substance pemetrexed."
Pemetrexed is a chemical compound used as a drug.

Let's evaluate the senses:
1. **the real physical matter of which a person or thing consists:** This fits well. Pemetrexed is the physical matter/component of the drug.
2. **the choicest or most essential or most vital part of some idea or experience:** Abstract, irrelevant.
3. **the idea that is intended:** Abstract, irrelevant.
4. **material of a particular kind or constitution:** This is also very relevant. Pemetrexed is a specific material/chemical type.
5. **considerable capital (wealth or income):** Irrelevant.
6. **what a communication that is about something is about:** Irrelevant.
7. **a particular kind or species of matter with uniform properties:** This is also highly relevant, describing a chemical/physical entity.

Comparing 1, 4, and 7:
*   Sense 1 (real physical matter): General definition of a component.
*   Sense 4 (material of a particular kind or constitution): Focuses on the classification/type of material.
*   Sense 7 (a particular kind or species of matter with uniform properties): Highly specific to chemical/physical entities, which is appropriate for an "active substance" in medicine.

In the context of pharmaceuticals, "active substance" refers to the specific chemical ingredient responsible for the drug's effect. Sense 7, "a particular kind or species of matter with uniform properties," captures this chemical specificity best. Sense 1 is too general, and Sense 4 is slightly less precise than Sense 7 in describing a defined chemical entity.

Therefore, Sense 7 is the best fit.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: used
Context:
If you need more information about your medical condition or your treatment, read the Package Leaflet (also part of the EPAR) or contact your doctor or pharmacist. If you want more information on the basis of the CHMP recommendations, read the Scientific Discussion (also part of the EPAR). What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta <t>used</t> for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos).

Candidate senses:
1. sense_key=use%2:34:01:: | definition=put into service; make work or employ for a particular purpose or for its inherent or natural purpose | synonyms=utilize, utilise, apply, employ | examples=use your head!; we only use Spanish at home
2. sense_key=use%2:34:02:: | definition=take or consume (regularly or habitually) | synonyms=habituate | examples=She uses drugs rarely
3. sense_key=use%2:34:00:: | definition=use up, consume fully | synonyms=expend | examples=The legislature expended its time on school questions
4. sense_key=use%2:41:14:: | definition=seek or achieve an end by using to one's advantage | examples=She uses her influential friends to get jobs; The president's wife used her good connections
5. sense_key=use%2:41:04:: | definition=avail oneself to | synonyms=practice, apply | examples=apply a principle; practice a religion
6. sense_key=use%2:41:03:: | definition=habitually do something (use only in the past tense) | examples=She used to call her mother every week but now she calls only occasionally; I used to get sick when I ate in that dining hall

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
Thinking Process:

1.  **Analyze the Context:** The sentence is: "What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta <t>used</t> for? Alimta is used to treat two types of cancer: pleural mesothelioma..."
2.  **Identify the Target Word and Form:** Target lemma is 'use', surface form is 'used'.
3.  **Determine the Meaning in Context:** The question "What is Alimta used for?" asks about the *purpose* or *function* of the drug Alimta. The answer confirms this: "Alimta is used to treat two types of cancer." This means Alimta is employed or utilized for the specific purpose of treating cancer.
4.  **Evaluate Candidate Senses:**

    *   **1. sense_key=use%2:34:01::** | definition=put into service; make work or employ for a particular purpose or for its inherent or natural purpose | synonyms=utilize, utilise, apply, employ | *Match:* This perfectly matches the idea of employing a substance (Alimta) for a specific purpose (treating cancer).
    *   **2. sense_key=use%2:34:02::** | definition=take or consume (regularly or habitually) | synonyms=habituate | *Mismatch:* While drugs are consumed, the context asks *what it is used for* (its function/purpose), not merely that it is consumed.
    *   **3. sense_key=use%2:34:00::** | definition=use up, consume fully | synonyms=expend | *Mismatch:* This refers to depletion or exhaustion, which is irrelevant here.
    *   **4. sense_key=use%2:41:14::** | definition=seek or achieve an end by using to one's advantage | *Mismatch:* This usually applies to people or resources (e.g., using friends to get jobs), not the function of a medical substance.
    *   **5. sense_key=use%2:41:04::** | definition=avail oneself to | synonyms=practice, apply | *Mismatch:* This means benefiting from something (e.g., applying a principle), not defining the function of the substance itself.
    *   **6. sense_key=use%2:41:03::** | definition=habitually do something (use only in the past tense) | *Mismatch:* This refers to past habits ("used to"), which is not the meaning here.

5.  **Select the Best Sense:** Sense 1 (put into service; employ for a particular purpose) is the most accurate fit for describing the therapeutic function of a drug.

6.  **Format the Output:** Generate the required JSON object.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: used
Context:
If you want more information on the basis of the CHMP recommendations, read the Scientific Discussion (also part of the EPAR). What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is <t>used</t> to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells.

Candidate senses:
1. sense_key=use%2:34:01:: | definition=put into service; make work or employ for a particular purpose or for its inherent or natural purpose | synonyms=utilize, utilise, apply, employ | examples=use your head!; we only use Spanish at home
2. sense_key=use%2:34:02:: | definition=take or consume (regularly or habitually) | synonyms=habituate | examples=She uses drugs rarely
3. sense_key=use%2:34:00:: | definition=use up, consume fully | synonyms=expend | examples=The legislature expended its time on school questions
4. sense_key=use%2:41:14:: | definition=seek or achieve an end by using to one's advantage | examples=She uses her influential friends to get jobs; The president's wife used her good connections
5. sense_key=use%2:41:04:: | definition=avail oneself to | synonyms=practice, apply | examples=apply a principle; practice a religion
6. sense_key=use%2:41:03:: | definition=habitually do something (use only in the past tense) | examples=She used to call her mother every week but now she calls only occasionally; I used to get sick when I ate in that dining hall

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "used" (past tense of "use") based on the provided context.

Context: "What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma..."

Target word: used
Lemma: use

Candidate senses:
1. sense_key=use%2:34:01:: | definition=put into service; make work or employ for a particular purpose or for its inherent or natural purpose | synonyms=utilize, utilise, apply, employ | examples=use your head!; we only use Spanish at home
2. sense_key=use%2:34:02:: | definition=take or consume (regularly or habitually) | synonyms=habituate | examples=She uses drugs rarely
3. sense_key=use%2:34:00:: | definition=use up, consume fully | synonyms=expend | examples=The legislature expended its time on school questions
4. sense_key=use%2:41:14:: | definition=seek or achieve an end by using to one's advantage | examples=She uses her influential friends to get jobs; The president's wife used her good connections
5. sense_key=use%2:41:04:: | definition=avail oneself to | synonyms=practice, apply | examples=apply a principle; practice a religion
6. sense_key=use%2:41:03:: | definition=habitually do something (use only in the past tense) | examples=She used to call her mother every week but now she calls only occasionally; I used to get sick when I ate in that dining hall

Analysis:
The sentence is: "Alimta is used to treat two types of cancer..."
Here, "Alimta" (a powder/solution) is being employed or applied for the specific purpose of treating cancer.

Let's evaluate the senses:
1. sense_key=use%2:34:01: "put into service; make work or employ for a particular purpose..." This perfectly matches the context: Alimta is employed/put into service for the purpose of treating cancer.
2. sense_key=use%2:34:02: "take or consume (regularly or habitually)." This relates to consumption, but the context is about therapeutic application, not consumption in the sense of habituation.
3. sense_key=use%2:34:00: "use up, consume fully." This means depletion, which is incorrect.
4. sense_key=use%2:41:14: "seek or achieve an end by using to one's advantage." This usually refers to using people or resources strategically (e.g., using friends for jobs), not applying a drug for a medical purpose.
5. sense_key=use%2:41:04: "avail oneself to." This is about utilizing a resource or method (e.g., applying a principle), which is close, but sense 1 is more direct regarding the function/purpose of an object/substance.
6. sense_key=use%2:41:03: "habitually do something (use only in the past tense)." This refers to past habits ("used to"), which is not the meaning here.

Sense 1, "put into service; make work or employ for a particular purpose," is the most accurate description of how a medicine is "used" in a medical context.

The best sense is 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: treat
Target surface form: treat
Context:
If you want more information on the basis of the CHMP recommendations, read the Scientific Discussion (also part of the EPAR). What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to <t>treat</t> two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells.

Candidate senses:
1. sense_key=treat%2:41:00:: | definition=interact in a certain way | synonyms=handle, do by | examples=Do right by her; Treat him with caution, please
2. sense_key=treat%2:30:01:: | definition=subject to a process or treatment, with the aim of readying for some purpose, improving, or remedying a condition | synonyms=process | examples=process cheese; process hair
3. sense_key=treat%2:29:00:: | definition=provide treatment for | synonyms=care for | examples=The doctor treated my broken leg; The nurses cared for the bomb victims
4. sense_key=treat%2:32:00:: | definition=act on verbally or in some form of artistic expression | synonyms=cover, handle, plow, deal, address | examples=This book deals with incest; The course covered all of Western Civilization
5. sense_key=treat%2:40:00:: | definition=provide with a gift or entertainment | examples=Grandmother always treated us to the circus; I like to treat myself to a day at a spa when I am depressed
6. sense_key=treat%2:34:00:: | definition=provide with choice or abundant food or drink | synonyms=regale | examples=Don't worry about the expensive wine--I'm treating; She treated her houseguests with good food every night
7. sense_key=treat%2:32:03:: | definition=engage in negotiations in order to reach an agreement | examples=they had to treat with the King
8. sense_key=treat%2:31:00:: | definition=regard or consider in a specific way | examples=I treated his advances as a joke

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "treat" in the given context.

Context: "Alimta is used to <t>treat</t> two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells."

The word "treat" is used in the context of cancer and chemotherapy/medicine.

Let's examine the candidate senses:

1. `sense_key=treat%2:41:00`: interact in a certain way (synonyms=handle, do by). Examples: Do right by her; Treat him with caution. (Not related to medical treatment.)
2. `sense_key=treat%2:30:01`: subject to a process or treatment, with the aim of readying for some purpose, improving, or remedying a condition (synonyms=process). Examples: process cheese; process hair. (This is about being processed, not providing medical care.)
3. `sense_key=treat%2:29:00`: provide treatment for (synonyms=care for). Examples: The doctor treated my broken leg; The nurses cared for the bomb victims. (This perfectly matches the medical context: Alimta is used to provide treatment for cancer.)
4. `sense_key=treat%2:32:00`: act on verbally or in some form of artistic expression (synonyms=cover, handle, plow, deal, address). Examples: This book deals with incest; The course covered all of Western Civilization. (Not related to medical treatment.)
5. `sense_key=treat%2:40:00`: provide with a gift or entertainment. Examples: Grandmother always treated us to the circus. (Not related to medical treatment.)
6. `sense_key=treat%2:34:00`: provide with choice or abundant food or drink (synonyms=regale). Examples: I'm treating. (Not related to medical treatment.)
7. `sense_key=treat%2:32:03`: engage in negotiations in order to reach an agreement. Examples: they had to treat with the King. (Not related to medical treatment.)
8. `sense_key=treat%2:31:00`: regard or consider in a specific way. Examples: I treated his advances as a joke. (Not related to medical treatment.)

Sense 3 (`treat%2:29:00`) is the only sense that fits the context of using a medicine (Alimta) to combat a disease (cancer).

Therefore, the best sense is 3.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: type
Target surface form: types
Context:
If you want more information on the basis of the CHMP recommendations, read the Scientific Discussion (also part of the EPAR). What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two <t>types</t> of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells.

Candidate senses:
1. sense_key=type%1:09:00:: | definition=a subdivision of a particular kind of thing | examples=what type of sculpture do you prefer?
2. sense_key=type%1:18:00:: | definition=a person of a specified kind (usually with many eccentricities) | synonyms=character, eccentric, case | examples=a real character; a strange character
3. sense_key=type%1:14:01:: | definition=(biology) the taxonomic group whose characteristics are used to define the next higher taxon
4. sense_key=type%1:10:01:: | definition=printed characters | examples=small type is hard to read
5. sense_key=type%1:10:00:: | definition=all of the tokens of the same symbol | examples=the word `element' contains five different types of character
6. sense_key=type%1:06:00:: | definition=a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper | examples=he dropped a case of type, so they made him pick them up

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "types" (lemma: type) in the given context.

Context: "Alimta is used to treat two <t>types</t> of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos)."

The word "types" is used here to categorize or classify different kinds of cancer that the drug Alimta is used to treat.

Let's examine the candidate senses:

1. **sense_key=type%1:09:00:: | definition=a subdivision of a particular kind of thing | examples=what type of sculpture do you prefer?**
   * This definition ("a subdivision of a particular kind of thing") perfectly matches the usage: "two types of cancer" means two subdivisions/kinds of cancer.

2. **sense_key=type%1:18:00:: | definition=a person of a specified kind (usually with many eccentricities) | synonyms=character, eccentric, case | examples=a real character; a strange character**
   * This refers to a personality/character. Incorrect.

3. **sense_key=type%1:14:01:: | definition=(biology) the taxonomic group whose characteristics are used to define the next higher taxon**
   * This is a specific biological/taxonomic classification (e.g., species, genus). While cancer is biological, the context is classifying *kinds* of cancer treated by the drug, not defining a formal taxonomic rank. Sense 1 is broader and fits better for general classification.

4. **sense_key=type%1:10:01:: | definition=printed characters | examples=small type is hard to read**
   * Refers to typography. Incorrect.

5. **sense_key=type%1:10:00:: | definition=all of the tokens of the same symbol | examples=the word `element' contains five different types of character**
   * Refers to character sets/symbols. Incorrect.

6. **sense_key=type%1:06:00:: | definition=a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper | examples=he dropped a case of type, so they made him pick them up**
   * Refers to printing blocks/type metal. Incorrect.

The context clearly uses "types" in the sense of "kinds" or "categories." Sense 1, "a subdivision of a particular kind of thing," is the most appropriate fit.

Therefore, the correct sense index is 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
If you want more information on the basis of the CHMP recommendations, read the Scientific Discussion (also part of the EPAR). What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of <t>cancer</t>: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "cancer" in the provided context.

Context analysis:
The text discusses a drug (Alimta) used to treat specific conditions.
"Alimta is used to treat two types of <t>cancer</t>: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos)."
The context immediately links "cancer" to "pleural mesothelioma," which is defined as "cancer of the lining of the lungs."
The text further mentions "anticancer medicine," "malignant," "advanced or metastatic non-small cell lung cancer," and "chemotherapy (medicines for cancer)."

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Evaluation:
Senses 2, 3, 4, and 5 relate to astrology or biology (crabs/genera) and are clearly irrelevant to the medical context.
Sense 1 defines "cancer" as "any malignant growth or tumor caused by abnormal and uncontrolled cell division," which perfectly matches the medical usage in the context (pleural mesothelioma, malignant, chemotherapy, etc.).

Conclusion: Sense 1 is the correct sense.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
If you want more information on the basis of the CHMP recommendations, read the Scientific Discussion (also part of the EPAR). What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (<t>cancer</t> of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the context:** The sentence is: "Alimta is used to treat two types of cancer: pleural mesothelioma (<t>cancer</t> of the lining of the lungs that is usually caused by exposure to asbestos)." The surrounding text discusses Alimta, a drug containing pemetrexed, used to treat various types of cancer (e.g., non-small cell lung cancer, malignant disease).
2.  **Determine the meaning of 'cancer' in context:** Here, 'cancer' refers to a malignant disease or tumor affecting the lining of the lungs (pleural mesothelioma).
3.  **Examine the candidate senses:**
    *   sense_key=cancer%1:26:00: Definition: "any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body..." Synonyms: "malignant neoplastic disease." (This matches the medical context.)
    *   sense_key=cancer%1:18:00: Definition: "(astrology) a person who is born while the sun is in Cancer." (Astrology/Zodiac - Incorrect.)
    *   sense_key=cancer%1:17:00: Definition: "a small zodiacal constellation in the northern hemisphere; between Leo and Gemini." (Astrology/Zodiac - Incorrect.)
    *   sense_key=cancer%1:15:00: Definition: "the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22." (Astrology/Zodiac - Incorrect.)
    *   sense_key=cancer%1:05:00: Definition: "type genus of the family Cancridae." (Biology/Zoology - Incorrect.)
4.  **Select the best sense:** Sense 1 (cancer%1:26:00) is the only sense referring to the medical condition, which perfectly fits the context of treating pleural mesothelioma and being discussed alongside chemotherapy and malignant disease.
5.  **Format the output:** The instruction requires returning only a JSON object with the sense index.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: lining
Target surface form: lining
Context:
If you want more information on the basis of the CHMP recommendations, read the Scientific Discussion (also part of the EPAR). What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the <t>lining</t> of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells.

Candidate senses:
1. sense_key=lining%1:06:00:: | definition=a protective covering that protects an inside surface | synonyms=liner
2. sense_key=lining%1:06:01:: | definition=a piece of cloth that is used as the inside surface of a garment | synonyms=liner
3. sense_key=lining%1:04:01:: | definition=providing something with a surface of a different material | synonyms=facing
4. sense_key=lining%1:04:00:: | definition=the act of attaching an inside lining (to a garment or curtain etc.)

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "lining" in the given context.

Context: "Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the <t>lining</t> of the lungs that is usually caused by exposure to asbestos)."

Target word: lining
Contextual phrase: "lining of the lungs"

Candidate senses:
1. sense_key=lining%1:06:00:: | definition=a protective covering that protects an inside surface | synonyms=liner
2. sense_key=lining%1:06:01:: | definition=a piece of cloth that is used as the inside surface of a garment | synonyms=liner
3. sense_key=lining%1:04:01:: | definition=providing something with a surface of a different material | synonyms=facing
4. sense_key=lining%1:04:00:: | definition=the act of attaching an inside lining (to a garment or curtain etc.)

Analysis:
The context refers to "pleural mesothelioma," which is a cancer of the lining of the lungs. The lungs have internal surfaces (the pleura) that are covered by a protective layer.

Sense 1: "a protective covering that protects an inside surface". This perfectly matches the biological context of the pleura/lining of the lungs.
Sense 2: "a piece of cloth that is used as the inside surface of a garment". This is related to clothing, not lungs.
Sense 3: "providing something with a surface of a different material". This is usually a verb or gerund form (e.g., lining a box), but the context uses "lining" as a noun referring to the structure itself.
Sense 4: "the act of attaching an inside lining". This is the action, not the structure itself.

Conclusion: Sense 1 is the best fit as it describes the anatomical/biological function of the lining of the lungs (a protective covering of an inside surface).


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cause
Target surface form: caused
Context:
If you want more information on the basis of the CHMP recommendations, read the Scientific Discussion (also part of the EPAR). What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually <t>caused</t> by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells.

Candidate senses:
1. sense_key=cause%2:36:00:: | definition=give rise to; cause to happen or occur, not always intentionally | synonyms=do, make | examples=cause a commotion; make a stir
2. sense_key=cause%2:32:00:: | definition=cause to do; cause to act in a specified manner | synonyms=induce, stimulate, have, get, make | examples=The ads induced me to buy a VCR; My children finally got me to buy a computer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the target word and context:**
    *   Target surface form: "caused" (past tense of "cause").
    *   Context sentence: "Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually <t>caused</t> by exposure to asbestos)."
    *   The structure is: [Cancer] is caused by [exposure to asbestos].
    *   The relationship is between the disease (mesothelioma) and the factor leading to it (asbestos exposure).

2.  **Analyze the candidate senses:**

    *   **Sense 1 (cause%2:36:00):**
        *   Definition: give rise to; cause to happen or occur, not always intentionally.
        *   Synonyms: do, make.
        *   Examples: cause a commotion; make a stir.
        *   *Fit check:* Does "mesothelioma is caused by exposure to asbestos" fit "give rise to; cause to happen or occur"? Yes. Asbestos exposure is the agent that gives rise to the cancer.

    *   **Sense 2 (cause%2:32:00):**
        *   Definition: cause to do; cause to act in a specified manner.
        *   Synonyms: induce, stimulate, have, get, make.
        *   Examples: The ads induced me to buy a VCR; My children finally got me to buy a computer.
        *   *Fit check:* Does "mesothelioma is caused by exposure to asbestos" fit "cause to do"? No. This sense implies forcing an action or behavior (e.g., causing someone *to buy* something). The cancer is not performing an action that was caused by the asbestos; the cancer *is* the result of the exposure.

3.  **Determine the best sense:**
    *   Sense 1 perfectly matches the meaning of causation in the context of disease etiology (A causes B).
    *   Sense 2 relates to behavioral or volitional causation (A makes B do C).

4.  **Conclusion:** Sense 1 is the best fit.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: used
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is <t>used</t> together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=use%2:34:01:: | definition=put into service; make work or employ for a particular purpose or for its inherent or natural purpose | synonyms=utilize, utilise, apply, employ | examples=use your head!; we only use Spanish at home
2. sense_key=use%2:34:02:: | definition=take or consume (regularly or habitually) | synonyms=habituate | examples=She uses drugs rarely
3. sense_key=use%2:34:00:: | definition=use up, consume fully | synonyms=expend | examples=The legislature expended its time on school questions
4. sense_key=use%2:41:14:: | definition=seek or achieve an end by using to one's advantage | examples=She uses her influential friends to get jobs; The president's wife used her good connections
5. sense_key=use%2:41:04:: | definition=avail oneself to | synonyms=practice, apply | examples=apply a principle; practice a religion
6. sense_key=use%2:41:03:: | definition=habitually do something (use only in the past tense) | examples=She used to call her mother every week but now she calls only occasionally; I used to get sick when I ate in that dining hall

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "used" in the given context.
The target lemma is "use".
The context is about the drug Alimta and its application in treating cancer.

Context snippet: "Alimta is used to treat two types of cancer: pleural mesothelioma... Alimta is used together with cisplatin (another anticancer medicine)... Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past."

The word "used" here means "applied" or "employed" for the purpose of treating cancer.

Let's analyze the candidate senses:

1. **sense_key=use%2:34:01**: definition=put into service; make work or employ for a particular purpose or for its inherent or natural purpose | synonyms=utilize, utilise, apply, employ | examples=use your head!; we only use Spanish at home
    * This sense perfectly matches the context. Alimta is employed/utilized for the purpose of treating cancer.

2. **sense_key=use%2:34:02**: definition=take or consume (regularly or habitually) | synonyms=habituate | examples=She uses drugs rarely
    * This refers to consumption, which is possible for a drug, but the sentence structure ("Alimta is used to treat...") emphasizes the *purpose* or *application* of the drug, not just the act of taking it. Sense 1 is a better fit for the overall meaning of the sentence.

3. **sense_key=use%2:34:00**: definition=use up, consume fully | synonyms=expend | examples=The legislature expended its time on school questions
    * This means depletion or exhaustion. Not relevant here.

4. **sense_key=use%2:41:14**: definition=seek or achieve an end by using to one's advantage | examples=She uses her influential friends to get jobs; The president's wife used her good connections
    * This relates to leveraging resources or people for personal gain. Not relevant here.

5. **sense_key=use%2:41:04**: definition=avail oneself to | synonyms=practice, apply | examples=apply a principle; practice a religion
    * This means making use of something (like a skill or resource). While related to application, Sense 1 (put into service/employ for a purpose) is a more direct and comprehensive match for medical treatment application.

6. **sense_key=use%2:41:03**: definition=habitually do something (use only in the past tense) | examples=She used to call her mother every week but now she calls only occasionally; I used to get sick when I ate in that dining hall
    * This refers to past habits ("used to"). The context describes the current medical application of the drug.

Conclusion: Sense 1 (put into service; make work or employ for a particular purpose) is the best fit.

The required output format is a JSON object with the sense index.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer <t>medicine</t>) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "medicine" in the provided context.

Context snippet: "Alimta is used together with cisplatin (another anticancer <t>medicine</t>) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells."

The target word is "medicine" (in the phrase "another anticancer medicine").

Let's analyze the candidate senses:

1. **sense_key=medicine%1:09:00**: definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty. (Refers to a field of study/specialty, e.g., internal medicine).
2. **sense_key=medicine%1:06:00**: definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug. (Refers to a drug or treatment).
3. **sense_key=medicine%1:04:00**: definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard. (Refers to the profession/field of study).
4. **sense_key=medicine%1:04:02**: definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine. (Refers to punishment/figurative meaning).

Applying the context:
The phrase is "another anticancer medicine".
"Anticancer" describes something that fights cancer.
The context discusses cancer treatment (Alimta, cisplatin, chemotherapy).
The word "medicine" here refers to a substance or treatment used to fight cancer.

Comparing with senses:
1. Sense 1 (medical specialty): Incorrect. It's a substance, not a field of study.
2. Sense 2 (something that treats or prevents or alleviates the symptoms of disease): Correct. An anticancer drug fits this definition perfectly. Synonyms like "medication" and "medicinal drug" are highly relevant.
3. Sense 3 (the learned profession): Incorrect. It's a drug, not the profession.
4. Sense 4 (punishment): Incorrect.

The best fit is sense_key=medicine%1:06:00.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the <t>cancer</t> is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "cancer" based on the provided context and candidate senses.

Context analysis:
The text discusses a drug (Alimta) used to treat "two types of cancer: pleural mesothelioma (cancer of the lining of the lungs...)" and mentions "anticancer medicine," "chemotherapy (medicines for cancer)," and "advanced or metastatic non-small cell lung cancer."

The target word is `<t>cancer</t>` in the phrase: "...when the <t>cancer</t> is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body)..."

The context clearly refers to a disease, specifically a malignant growth or tumor.

Candidate senses analysis:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Matching the context to the senses:
The context uses "cancer" in a medical/pathological sense (unresectable, malignant, metastatic).
Sense 1 matches this definition perfectly: "any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body..."
Senses 2, 3, 4, and 5 relate to astrology or biology (crabs/genus) and are irrelevant to the medical context.

Therefore, sense 1 is the best fit.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: remove
Target surface form: removed
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be <t>removed</t> by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=remove%2:30:00:: | definition=remove something concrete, as by lifting, pushing, or taking off, or remove something abstract | synonyms=take, take away, withdraw | examples=remove a threat; remove a wrapper
2. sense_key=remove%2:41:00:: | definition=remove from a position or an office
3. sense_key=remove%2:40:00:: | definition=dispose of | synonyms=get rid of | examples=Get rid of these old shoes!; The company got rid of all the dead wood
4. sense_key=remove%2:41:02:: | definition=cause to leave | synonyms=take out, move out | examples=The teacher took the children out of the classroom
5. sense_key=remove%2:38:00:: | definition=shift the position or location of, as for business, legal, educational, or military purposes | synonyms=transfer | examples=He removed his children to the countryside; Remove the troops to the forest surrounding the city
6. sense_key=remove%2:30:01:: | definition=go away or leave | synonyms=absent | examples=He absented himself
7. sense_key=remove%2:41:01:: | definition=kill intentionally and with premeditation | synonyms=murder, slay, hit, dispatch, bump off, off | examples=The mafia boss ordered his enemies murdered
8. sense_key=remove%2:30:02:: | definition=get rid of something abstract | synonyms=take away | examples=The death of her mother removed the last obstacle to their marriage; God takes away your sins

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "removed" (lemma: remove) based on the provided context.

Context: "Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be <t>removed</t> by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body)..."

The target word "removed" is used in the phrase "cannot be removed by surgery alone."
The object being acted upon is "cancer."
The action is "removed by surgery."

This refers to the surgical removal of a tumor or cancerous tissue.

Let's analyze the candidate senses:

1. **sense_key=remove%2:30:00::** | definition=remove something concrete, as by lifting, pushing, or taking off, or remove something abstract | synonyms=take, take away, withdraw | examples=remove a threat; remove a wrapper. (This covers concrete removal, like surgery.)
2. **sense_key=remove%2:41:00::** | definition=remove from a position or an office. (Relates to jobs/positions.)
3. **sense_key=remove%2:40:00::** | definition=dispose of | synonyms=get rid of | examples=Get rid of these old shoes!; The company got rid of all the dead wood. (This is about disposal, which is related, but sense 1 is more precise for surgical removal.)
4. **sense_key=remove%2:41:02::** | definition=cause to leave | synonyms=take out, move out | examples=The teacher took the children out of the classroom. (Relates to movement/exit.)
5. **sense_key=remove%2:38:00::** | definition=shift the position or location of, as for business, legal, educational, or military purposes | synonyms=transfer | examples=He removed his children to the countryside; Remove the troops to the forest surrounding the city. (Relates to relocation.)
6. **sense_key=remove%2:30:01::** | definition=go away or leave | synonyms=absent | examples=He absented himself. (Intransitive, meaning to leave.)
7. **sense_key=remove%2:41:01::** | definition=kill intentionally and with premeditation | synonyms=murder, slay, hit, dispatch, bump off, off | examples=The mafia boss ordered his enemies murdered. (Homicide.)
8. **sense_key=remove%2:30:02::** | definition=get rid of something abstract | synonyms=take away | examples=The death of her mother removed the last obstacle to their marriage; God takes away your sins. (Abstract removal.)

The context describes the physical removal of cancer by surgery.

Sense 1: "remove something concrete, as by lifting, pushing, or taking off, or remove something abstract." This perfectly matches the physical removal of a concrete object (cancer/tumor) via surgery.

Sense 3: "dispose of." While surgery results in disposal, the act described ("cannot be removed by surgery") is the physical extraction, which is better captured by the concrete removal aspect of Sense 1.

Therefore, Sense 1 is the best fit.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: surgery
Target surface form: surgery
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by <t>surgery</t> alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=surgery%1:09:00:: | definition=the branch of medical science that treats disease or injury by operative procedures | examples=he is professor of surgery at the Harvard Medical School
2. sense_key=surgery%1:06:01:: | definition=a room where a doctor or dentist can be consulted | examples=he read the warning in the doctor's surgery
3. sense_key=surgery%1:06:00:: | definition=a room in a hospital equipped for the performance of surgical operations | synonyms=operating room, OR, operating theater, operating theatre | examples=great care is taken to keep the operating rooms aseptic
4. sense_key=surgery%1:04:01:: | definition=a medical procedure involving an incision with instruments; performed to repair damage or arrest disease in a living body | synonyms=operation, surgical operation, surgical procedure, surgical process | examples=they will schedule the operation as soon as an operating room is available; he died while undergoing surgery

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "surgery" in the provided context.

Context:
"Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by <t>surgery</t> alone) and malignant..."

Target word: surgery

Candidate senses:
1. sense_key=surgery%1:09:00:: | definition=the branch of medical science that treats disease or injury by operative procedures | examples=he is professor of surgery at the Harvard Medical School (Refers to the field/discipline)
2. sense_key=surgery%1:06:01:: | definition=a room where a doctor or dentist can be consulted | examples=he read the warning in the doctor's surgery (Refers to a consultation room/office)
3. sense_key=surgery%1:06:00:: | definition=a room in a hospital equipped for the performance of surgical operations | synonyms=operating room, OR, operating theater, operating theatre | examples=great care is taken to keep the operating rooms aseptic (Refers to the physical location/room)
4. sense_key=surgery%1:04:01:: | definition=a medical procedure involving an incision with instruments; performed to repair damage or arrest disease in a living body | synonyms=operation, surgical operation, surgical procedure, surgical process | examples=they will schedule the operation as soon as an operating room is available; he died while undergoing surgery (Refers to the act/procedure itself)

Analysis of the context:
"...the cancer is unresectable (cannot be removed by surgery alone)..."

The phrase "cannot be removed by surgery alone" implies that "surgery" refers to the *act* or *procedure* of removal (surgical operation), not the field of medicine (sense 1), the room (sense 2 or 3), or the general concept of a procedure (though sense 4 is the closest match).

Let's compare sense 4 and sense 1.
Sense 1: The branch of medical science (e.g., "He is a surgeon"). If the context said "He is a surgeon, but the cancer is unresectable by his surgery," it might lean towards sense 1, but here, "surgery" is the method of removal.
Sense 4: A medical procedure involving an incision... (e.g., "The operation was successful"). "Cannot be removed by surgery alone" means the surgical procedure itself is insufficient.

Sense 4 fits perfectly: "surgery" here means the surgical procedure/operation.

Therefore, sense_key=surgery%1:04:01 is the best fit.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: alone
Target surface form: alone
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery <t>alone</t>) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=alone%5:00:00:unsocial:00 | definition=isolated from others | examples=could be alone in a crowded room; was alone with her thoughts
2. sense_key=alone%5:00:00:unaccompanied:00 | definition=lacking companions or companionship | synonyms=lone, lonely, solitary | examples=he was alone when we met him; she is alone much of the time
3. sense_key=alone%5:00:00:exclusive:00 | definition=exclusive of anyone or anything else | synonyms=only | examples=she alone believed him; cannot live by bread alone
4. sense_key=alone%5:00:00:incomparable:00 | definition=radically distinctive and without equal | synonyms=unique, unequaled, unequalled, unparalleled | examples=he is alone in the field of microbiology; this theory is altogether alone in its penetration of the problem

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "alone" in the provided context.

Context snippet: "Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery <t>alone</t>) and malignant..."

The word "alone" modifies "surgery" (cannot be removed by surgery alone).

Let's analyze the candidate senses:

1. **sense_key=alone%5:00:00:unsocial:00 | definition=isolated from others | examples=could be alone in a crowded room; was alone with her thoughts**
   * This relates to social isolation. The context is medical/surgical capability. This sense is unlikely.

2. **sense_key=alone%5:00:00:unaccompanied:00 | definition=lacking companions or companionship | synonyms=lone, lonely, solitary | examples=he was alone when we met him; she is alone much of the time**
   * This also relates to companionship/solitude. The context is medical/surgical capability. This sense is unlikely.

3. **sense_key=alone%5:00:00:exclusive:00 | definition=exclusive of anyone or anything else | synonyms=only | examples=she alone believed him; cannot live by bread alone**
   * Here, "alone" means "by itself" or "without anything else."
   * The phrase is "cannot be removed by surgery alone." This means it cannot be removed *only* by surgery; other methods (like chemotherapy, mentioned earlier) might be needed.
   * This matches the definition "exclusive of anyone or anything else" and the synonym "only."

4. **sense_key=alone%5:00:00:incomparable:00 | definition=radically distinctive and without equal | synonyms=unique, unequaled, unequalled, unparalleled | examples=he is alone in the field of microbiology; this theory is altogether alone in its penetration of the problem**
   * This means unique or unmatched. The context is about the method of removal (surgery), not its uniqueness compared to other surgeries. This sense is unlikely.

Conclusion: Sense 3, meaning "only" or "exclusive of anything else," is the correct fit for "surgery alone."

I must return the JSON object with the sense index.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: spread
Target surface form: spread
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has <t>spread</t>, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=spread%2:35:00:: | definition=distribute or disperse widely | synonyms=distribute | examples=The invaders spread their language all over the country
2. sense_key=spread%2:35:07:: | definition=become distributed or widespread | synonyms=propagate | examples=the infection spread; Optimism spread among the population
3. sense_key=spread%2:42:00:: | definition=spread across or over | synonyms=overspread | examples=A big oil spot spread across the water
4. sense_key=spread%2:35:03:: | definition=spread out or open from a closed or folded state | synonyms=unfold, spread out, open | examples=open the map; spread your arms
5. sense_key=spread%2:32:00:: | definition=cause to become widely known | synonyms=circulate, circularize, circularise, distribute, disseminate, propagate | examples=spread information; circulate a rumor
6. sense_key=spread%2:32:02:: | definition=become widely known and passed on | synonyms=go around, circulate | examples=the rumor spread; the story went around in the office
7. sense_key=spread%2:38:00:: | definition=strew or distribute over an area | synonyms=scatter, spread out | examples=He spread fertilizer over the lawn; scatter cards across the table
8. sense_key=spread%2:38:02:: | definition=move outward | synonyms=diffuse, spread out, fan out | examples=The soldiers fanned out
9. sense_key=spread%2:35:12:: | definition=cover by spreading something over | examples=spread the bread with cheese
10. sense_key=spread%2:35:13:: | definition=distribute over a surface in a layer | examples=spread cheese on a piece of bread

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the context:** The target word is "spread" in the phrase "malignant (has <t>spread</t>, or is likely to spread easily, to other parts of the body)". This phrase is discussing cancer (pleural mesothelioma, non-small cell lung cancer).
2.  **Determine the meaning in context:** In the context of cancer, "spread" refers to the disease moving from its original site to other parts of the body. This is medically known as metastasis.
3.  **Examine the candidate senses:**
    *   1. distribute or disperse widely (General distribution)
    *   2. become distributed or widespread (General propagation, e.g., infection)
    *   3. spread across or over (Physical coverage, e.g., oil spot)
    *   4. spread out or open from a closed or folded state (Physical action, e.g., map)
    *   5. cause to become widely known (Information dissemination)
    *   6. become widely known and passed on (Rumor/information)
    *   7. strew or distribute over an area (Physical scattering, e.g., fertilizer)
    *   8. move outward (Physical movement, e.g., soldiers fanning out)
    *   9. cover by spreading something over (Physical application, e.g., bread)
    *   10. distribute over a surface in a layer (Physical application, e.g., cheese)
4.  **Match the context meaning to the senses:** The context requires a sense related to the physical or biological movement of a disease (cancer) to new locations in the body.
    *   Sense 2 ("become distributed or widespread," synonyms: propagate, examples: the infection spread) is a strong candidate, as cancer is a type of biological propagation/distribution.
    *   Sense 1 ("distribute or disperse widely") is also possible, but Sense 2 emphasizes the *becoming* widespread, which fits the description of cancer progression ("is likely to spread easily").
    *   Sense 3 ("spread across or over") is too focused on a surface/area, not necessarily internal body parts.
5.  **Refine the choice (Cancer/Metastasis):** When cancer spreads, it is propagating or metastasizing. Sense 2, "become distributed or widespread," captures this biological propagation best, especially given the example "the infection spread."
6.  **Final Selection:** Sense 2 is the most appropriate fit for the biological process of cancer spreading to other parts of the body.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: likely
Target surface form: likely
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is <t>likely</t> to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=likely%3:00:00:: | definition=has a good chance of being the case or of coming about | examples=these services are likely to be available to us all before long; she is likely to forget
2. sense_key=likely%3:00:04:: | definition=likely but not certain to be or become true or real | synonyms=probable | examples=a likely result; he foresaw a probable loss
3. sense_key=likely%5:00:00:prospective:00 | definition=expected to become or be; in prospect | synonyms=potential | examples=potential clients
4. sense_key=likely%5:00:00:credible:00 | definition=within the realm of credibility | examples=not a very likely excuse

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "likely" in the provided context.

Context snippet: "...and malignant (has spread, or is <t>likely</t> to spread easily, to other parts of the body)..."

Target word: likely

Candidate senses:
1. sense_key=likely%3:00:00:: | definition=has a good chance of being the case or of coming about | examples=these services are likely to be available to us all before long; she is likely to forget
2. sense_key=likely%3:00:04:: | definition=likely but not certain to be or become true or real | synonyms=probable | examples=a likely result; he foresaw a probable loss
3. sense_key=likely%5:00:00:prospective:00 | definition=expected to become or be; in prospect | synonyms=potential | examples=potential clients
4. sense_key=likely%5:00:00:credible:00 | definition=within the realm of credibility | examples=not a very likely excuse

Analysis:
The phrase is "is likely to spread easily, to other parts of the body."
This describes the nature of the cancer (malignant). The spread is not guaranteed, but it has a high probability of happening.

Let's evaluate the senses:
1. sense_key=likely%3:00:00: "has a good chance of being the case or of coming about." This fits the idea of a high probability of spreading.
2. sense_key=likely%3:00:04: "likely but not certain to be or become true or real." This also fits the idea of probability, emphasizing uncertainty, which is appropriate when describing cancer spread (it might not spread, but it is likely to).
3. sense_key=likely%5:00:00:prospective:00: "expected to become or be; in prospect." This usually refers to future potential or development (e.g., prospective clients). While related to future events, it doesn't capture the probabilistic nature as well as 1 or 2.
4. sense_key=likely%5:00:00:credible:00: "within the realm of credibility." This relates to believability (e.g., a likely excuse). This is irrelevant here.

Comparing Sense 1 and Sense 2:
Sense 1: "has a good chance of being the case or of coming about." (Strong probability)
Sense 2: "likely but not certain to be or become true or real." (Probable, acknowledging uncertainty)

In the medical context of cancer malignancy, stating that it is "likely to spread" means that the probability of metastasis is high, but not 100%. Both senses capture this. However, Sense 2 explicitly includes the nuance of "not certain," which is often the most precise way to describe biological probability in a clinical context. Sense 1 is slightly broader ("has a good chance").

Let's re-examine the examples provided for Sense 2: "a likely result; he foresaw a probable loss." These examples emphasize the prediction based on probability.

Given the context "is likely to spread easily," Sense 2 ("likely but not certain to be or become true or real") seems the most precise fit for describing a probabilistic biological outcome.

I will choose Sense 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: spread
Target surface form: spread
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to <t>spread</t> easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=spread%2:35:00:: | definition=distribute or disperse widely | synonyms=distribute | examples=The invaders spread their language all over the country
2. sense_key=spread%2:35:07:: | definition=become distributed or widespread | synonyms=propagate | examples=the infection spread; Optimism spread among the population
3. sense_key=spread%2:42:00:: | definition=spread across or over | synonyms=overspread | examples=A big oil spot spread across the water
4. sense_key=spread%2:35:03:: | definition=spread out or open from a closed or folded state | synonyms=unfold, spread out, open | examples=open the map; spread your arms
5. sense_key=spread%2:32:00:: | definition=cause to become widely known | synonyms=circulate, circularize, circularise, distribute, disseminate, propagate | examples=spread information; circulate a rumor
6. sense_key=spread%2:32:02:: | definition=become widely known and passed on | synonyms=go around, circulate | examples=the rumor spread; the story went around in the office
7. sense_key=spread%2:38:00:: | definition=strew or distribute over an area | synonyms=scatter, spread out | examples=He spread fertilizer over the lawn; scatter cards across the table
8. sense_key=spread%2:38:02:: | definition=move outward | synonyms=diffuse, spread out, fan out | examples=The soldiers fanned out
9. sense_key=spread%2:35:12:: | definition=cover by spreading something over | examples=spread the bread with cheese
10. sense_key=spread%2:35:13:: | definition=distribute over a surface in a layer | examples=spread cheese on a piece of bread

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "spread" in the given context.

Context snippet: "...and malignant (has spread, or is likely to <t>spread</t> easily, to other parts of the body)..."

The context relates to cancer (malignant) and its progression to "other parts of the body." This refers to the biological process of cancer cells moving from the primary site to distant sites (metastasis).

Let's analyze the candidate senses:

1. **sense_key=spread%2:35:00::** | definition=distribute or disperse widely | synonyms=distribute | examples=The invaders spread their language all over the country. (Focuses on distribution, often abstract/physical objects/ideas).
2. **sense_key=spread%2:35:07::** | definition=become distributed or widespread | synonyms=propagate | examples=the infection spread; Optimism spread among the population. (Focuses on becoming widespread, often abstract/biological/ideas).
3. **sense_key=spread%2:42:00::** | definition=spread across or over | synonyms=overspread | examples=A big oil spot spread across the water. (Focuses on covering a surface).
4. **sense_key=spread%2:35:03::** | definition=spread out or open from a closed or folded state | synonyms=unfold, spread out, open | examples=open the map; spread your arms. (Focuses on physical opening).
5. **sense_key=spread%2:32:00::** | definition=cause to become widely known | synonyms=circulate, circularize, circularise, distribute, disseminate, propagate | examples=spread information; circulate a rumor. (Focuses on information dissemination).
6. **sense_key=spread%2:32:02::** | definition=become widely known and passed on | synonyms=go around, circulate | examples=the rumor spread; the story went around in the office. (Focuses on rumor/story dissemination).
7. **sense_key=spread%2:38:00::** | definition=strew or distribute over an area | synonyms=scatter, spread out | examples=He spread fertilizer over the lawn; scatter cards across the table. (Focuses on scattering physical objects).
8. **sense_key=spread%2:38:02::** | definition=move outward | synonyms=diffuse, spread out, fan out | examples=The soldiers fanned out. (Focuses on physical movement outward).
9. **sense_key=spread%2:35:12::** | definition=cover by spreading something over | examples=spread the bread with cheese. (Focuses on covering a surface).
10. **sense_key=spread%2:35:13::** | definition=distribute over a surface in a layer | examples=spread cheese on a piece of bread. (Focuses on layering on a surface).

The context "is likely to spread easily, to other parts of the body" clearly refers to the biological process of metastasis, where cancer cells move and establish themselves in new locations.

Sense 2: "become distributed or widespread" with synonyms like "propagate" and example "the infection spread" is the closest match for biological/pathological dissemination.
Sense 1: "distribute or disperse widely" is also possible, but Sense 2 captures the *process* of becoming widespread, which fits the biological progression better.

Comparing Sense 2 and Sense 1:
Sense 2: definition=become distributed or widespread; synonyms=propagate; examples=the infection spread. (This perfectly matches the concept of cancer spreading/propagating to other parts of the body).
Sense 1: definition=distribute or disperse widely; synonyms=distribute; examples=The invaders spread their language all over the country. (This is too general and often relates to non-biological distribution).

Therefore, Sense 2 is the best fit.