[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: see
Target surface form: see
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=see%2:39:00:: | definition=perceive by sight or have the power to perceive by sight | examples=You have to be a good observer to see all the details; Can you see the bird in that tree?
2. sense_key=see%2:31:01:: | definition=perceive (an idea or situation) mentally | synonyms=understand, realize, realise | examples=Now I see!; I just can't see your point
3. sense_key=see%2:39:02:: | definition=perceive or be contemporaneous with | synonyms=witness, find | examples=We found Republicans winning the offices; You'll see a lot of cheating in this school
4. sense_key=see%2:36:00:: | definition=imagine; conceive of; see in one's mind | synonyms=visualize, visualise, envision, project, fancy, figure | examples=I can't see him on horseback!; I can see what will happen
5. sense_key=see%2:31:00:: | definition=deem to be | synonyms=consider, reckon, view, regard | examples=She views this quite differently from me; I consider her to be shallow
6. sense_key=see%2:31:02:: | definition=get to know or become aware of, usually accidentally | synonyms=learn, hear, get word, get wind, pick up, find out | examples=I learned that she has two grown-up children; I see that you have been promoted
7. sense_key=see%2:39:03:: | definition=see or watch | synonyms=watch, view, catch, take in | examples=view a show on television; This program will be seen all over the world
8. sense_key=see%2:38:00:: | definition=come together | synonyms=meet, run into, encounter, run across, come across | examples=I'll probably see you at the meeting; How nice to see you again!
9. sense_key=see%2:32:00:: | definition=find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, find out, ascertain, watch, learn | examples=I want to see whether she speaks French; See whether it works
10. sense_key=see%2:31:03:: | definition=be careful or certain to do something; make certain of something | synonyms=check, insure, see to it, ensure, control, ascertain | examples=He verified that the valves were closed; See that the curtains are closed
11. sense_key=see%2:41:11:: | definition=go to see for professional or business reasons | examples=You should see a lawyer; We had to see a psychiatrist
12. sense_key=see%2:41:12:: | definition=go to see for a social visit | examples=I went to see my friend Mary the other day
13. sense_key=see%2:41:10:: | definition=go to see a place, as for entertainment | synonyms=visit | examples=We went to see the Eiffel Tower in the morning
14. sense_key=see%2:41:14:: | definition=take charge of or deal with | synonyms=attend, take care, look | examples=Could you see about lunch?; I must attend to this matter
15. sense_key=see%2:35:09:: | definition=receive as a specified guest | examples=the doctor will see you now; The minister doesn't see anybody before noon
16. sense_key=see%2:41:00:: | definition=date regularly; have a steady relationship with | synonyms=go steady, go out, date | examples=Did you know that she is seeing an older man?; He is dating his former wife again!
17. sense_key=see%2:39:05:: | definition=see and understand, have a good eye | examples=The artist must first learn to see
18. sense_key=see%2:31:08:: | definition=deliberate or decide | examples=See whether you can come tomorrow; let's see--which movie should we see tonight?
19. sense_key=see%2:39:11:: | definition=observe as if with an eye | examples=The camera saw the burglary and recorded it
20. sense_key=see%2:39:13:: | definition=observe, check out, and look over carefully or inspect | synonyms=examine | examples=The customs agent examined the baggage; I must see your passport before you can enter the country
21. sense_key=see%2:39:12:: | definition=go or live through | synonyms=experience, go through | examples=We had many trials to go through; he saw action in Viet Nam
22. sense_key=see%2:38:03:: | definition=accompany or escort | synonyms=escort | examples=I'll see you to the door
23. sense_key=see%2:33:00:: | definition=match or meet | examples=I saw the bet of one of my fellow players
24. sense_key=see%2:31:13:: | definition=make sense of; assign a meaning to | synonyms=interpret, construe | examples=What message do you see in this letter?; How do you interpret his behavior?

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "see" in the given context.

Context: "For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?"

The word "see" is used here in the imperative form, instructing the reader where to find more information. This usage typically means "refer to" or "look at."

Let's examine the candidate senses:

1. sense_key=see%2:39:00:: | definition=perceive by sight or have the power to perceive by sight | (Literal sight) - Unlikely in this context.
2. sense_key=see%2:31:01:: | definition=perceive (an idea or situation) mentally | (Understand) - Not about understanding, but about locating information.
3. sense_key=see%2:39:02:: | definition=perceive or be contemporaneous with | (Witness/Find) - Less likely.
4. sense_key=see%2:36:00:: | definition=imagine; conceive of; see in one's mind | (Visualize) - Incorrect.
5. sense_key=see%2:31:00:: | definition=deem to be | (Consider) - Incorrect.
6. sense_key=see%2:31:02:: | definition=get to know or become aware of, usually accidentally | (Find out) - Possible, but usually used as "I see that..."
7. sense_key=see%2:39:03:: | definition=see or watch | (Watch) - Possible, but "refer to" is more precise.
8. sense_key=see%2:38:00:: | definition=come together | (Meet) - Incorrect.
9. sense_key=see%2:32:00:: | definition=find out, learn, or determine with certainty, usually by making an inquiry or other effort | (Determine/Check) - This sense relates to finding information, which aligns with "refer to."
10. sense_key=see%2:31:03:: | definition=be careful or certain to do something; make certain of something | (Ensure) - Incorrect.
11. sense_key=see%2:41:11:: | definition=go to see for professional or business reasons | (Visit professional) - Incorrect.
12. sense_key=see%2:41:12:: | definition=go to see for a social visit | (Visit social) - Incorrect.
13. sense_key=see%2:41:10:: | definition=go to see a place, as for entertainment | (Visit place) - Incorrect.
14. sense_key=see%2:41:14:: | definition=take charge of or deal with | (Attend to) - Incorrect.
15. sense_key=see%2:35:09:: | definition=receive as a specified guest | (Receive patient) - Incorrect.
16. sense_key=see%2:41:00:: | definition=date regularly; have a steady relationship with | (Date) - Incorrect.
17. sense_key=see%2:39:05:: | definition=see and understand, have a good eye | (Perceive/Understand) - Incorrect.
18. sense_key=see%2:31:08:: | definition=deliberate or decide | (Decide) - Incorrect.
19. sense_key=see%2:39:11:: | definition=observe as if with an eye | (Observe) - Incorrect.
20. sense_key=see%2:39:13:: | definition=observe, check out, and look over carefully or inspect | (Inspect) - Possible, but "refer to" is broader.
21. sense_key=see%2:39:12:: | definition=go or live through | (Experience) - Incorrect.
22. sense_key=see%2:38:03:: | definition=accompany or escort | (Escort) - Incorrect.
23. sense_key=see%2:33:00:: | definition=match or meet | (Match) - Incorrect.
24. sense_key=see%2:31:13:: | definition=make sense of; assign a meaning to | (Interpret) - Incorrect.

The usage "see [document/section]" is a common phrasal instruction meaning "refer to" or "consult."

Sense 9: "find out, learn, or determine with certainty, usually by making an inquiry or other effort." This captures the essence of consulting a document to find information.

While there isn't a perfect "refer to" sense, Sense 9 is the closest functional match for directing the reader to a source of information to learn or determine something.

Let's re-evaluate Sense 7: "see or watch" (synonyms: watch, view, catch, take in). If the reader is told to "see the Summary," it implies viewing/reading it. This is also a strong candidate.

However, in technical/instructional writing, "see" often functions as a directive to *consult* or *check* (Sense 9).

If I must choose the single best fit:
"For more information, see the Summary..." -> This means "Consult the Summary to find out more."

Sense 9: "find out, learn, or determine with certainty, usually by making an inquiry or other effort." (This aligns perfectly with consulting a document for information.)

I will choose Sense 9.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: product
Target surface form: Product
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=product%1:06:01:: | definition=commodities offered for sale | synonyms=merchandise, ware | examples=good business depends on having good merchandise; that store offers a variety of products
2. sense_key=product%1:06:00:: | definition=an artifact that has been created by someone or some process | synonyms=production | examples=they improve their product every year; they export most of their agricultural production
3. sense_key=product%1:09:00:: | definition=a quantity obtained by multiplication | synonyms=mathematical product | examples=the product of 2 and 3 is 6
4. sense_key=product%1:27:00:: | definition=a chemical substance formed as a result of a chemical reaction | examples=a product of lime and nitric acid
5. sense_key=product%1:19:00:: | definition=a consequence of someone's efforts or of a particular set of circumstances | examples=skill is the product of hours of practice; his reaction was the product of hunger and fatigue
6. sense_key=product%1:14:00:: | definition=the set of elements common to two or more sets | synonyms=intersection, Cartesian product | examples=the set of red hats is the intersection of the set of hats and the set of red things

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

finish_reason: stop

role: assistant

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "Product" in the given context.

Context: "It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR). How does Alimta work?"

The target word is "Product" in the phrase "Summary of Product Characteristics (also part of the EPAR)".

EPAR stands for European Public Assessment Report, which is a document detailing the characteristics and usage of a medicinal product (drug).

Let's analyze the candidate senses:

1. **sense_key=product%1:06:01:: | definition=commodities offered for sale | synonyms=merchandise, ware** (Refers to goods/merchandise.) - Unlikely, as the context is a drug/medical treatment.
2. **sense_key=product%1:06:00:: | definition=an artifact that has been created by someone or some process | synonyms=production** (Refers to a manufactured item or output.) - This fits well. A drug is a manufactured item/artifact.
3. **sense_key=product%1:09:00:: | definition=a quantity obtained by multiplication | synonyms=mathematical product** (Mathematical term.) - Incorrect.
4. **sense_key=product%1:27:00:: | definition=a chemical substance formed as a result of a chemical reaction** (Chemical output.) - While drugs are chemical substances, this sense usually refers to reaction byproducts, not the finished pharmaceutical item itself, especially in the context of a regulatory document (EPAR).
5. **sense_key=product%1:19:00:: | definition=a consequence of someone's efforts or of a particular set of circumstances** (Result/outcome.) - Incorrect.
6. **sense_key=product%1:14:00:: | definition=the set of elements common to two or more sets** (Set theory term.) - Incorrect.

The context refers to "Alimta" (a drug) and the "Summary of Product Characteristics (EPAR)". In pharmaceutical terminology, a "product" refers to the finished medicinal item itself.

Sense 2: "an artifact that has been created by someone or some process" (synonyms: production) is the best fit for a finished pharmaceutical item.

Therefore, sense_key=product%1:06:00 is the correct choice.

currency: USD

source: unavailable


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: part
Target surface form: part
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=part%1:24:00:: | definition=something determined in relation to something that includes it | synonyms=portion, component part, component, constituent | examples=he wanted to feel a part of something bigger than himself; I read a portion of the manuscript
2. sense_key=part%1:06:00:: | definition=something less than the whole of a human artifact | synonyms=portion | examples=the rear part of the house; glue the two parts together
3. sense_key=part%1:17:00:: | definition=a portion of a natural object | synonyms=piece | examples=they analyzed the river into three parts; he needed a piece of granite
4. sense_key=part%1:09:02:: | definition=that which concerns a person with regard to a particular role or situation | examples=it requires vigilance on our part; they resisted every effort on his part
5. sense_key=part%1:15:00:: | definition=the extended spatial location of something | synonyms=region | examples=the farming regions of France; religions in all parts of the world
6. sense_key=part%1:04:01:: | definition=the actions and activities assigned to or required or expected of a person or group | synonyms=function, office, role | examples=the function of a teacher; the government must do its part
7. sense_key=part%1:09:01:: | definition=an actor's portrayal of someone in a play | synonyms=character, role, theatrical role, persona | examples=she played the part of Desdemona
8. sense_key=part%1:21:00:: | definition=assets belonging to or due to or contributed by an individual person or group | synonyms=share, portion, percentage | examples=he wanted his share in cash
9. sense_key=part%1:09:00:: | definition=one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division | examples=the written part of the exam; the finance section of the company
10. sense_key=part%1:08:01:: | definition=a line of scalp that can be seen when sections of hair are combed in opposite directions | synonyms=parting | examples=his part was right in the middle
11. sense_key=part%1:10:00:: | definition=the melody carried by a particular voice or instrument in polyphonic music | synonyms=voice | examples=he tried to sing the tenor part
12. sense_key=part%1:04:03:: | definition=the part played by a person in bringing about a result | synonyms=contribution, share | examples=I am proud of my contribution in advancing the project; they all did their share of the work

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the context:** The target word is "part," and the context is: "For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR)."
2.  **Determine the meaning in context:** The phrase "Summary of Product Characteristics (also part of the EPAR)" indicates that the "Summary of Product Characteristics" is a component or section *within* the larger document, the "EPAR" (European Public Assessment Report, likely).
3.  **Examine the candidate senses:** I need a sense that means a component, section, or division of a whole document/report.

    *   1. something determined in relation to something that includes it (portion, component part, constituent). *Fits well (component).*
    *   2. something less than the whole of a human artifact (portion). *Fits, but perhaps too general.*
    *   3. a portion of a natural object (piece). *Irrelevant (natural objects).*
    *   4. that which concerns a person with regard to a particular role or situation (role). *Irrelevant (roles).*
    *   5. the extended spatial location of something (region). *Irrelevant (location).*
    *   6. the actions and activities assigned to or required or expected of a person or group (role). *Irrelevant (roles/functions).*
    *   7. an actor's portrayal of someone in a play (role). *Irrelevant (acting).*
    *   8. assets belonging to or due to or contributed by an individual person or group (share). *Irrelevant (finance/assets).*
    *   9. one of the portions into which something is regarded as divided and which together constitute a whole (section, division). *Fits extremely well (section/division of a document).*
    *   10. a line of scalp... (parting). *Irrelevant (hair).*
    *   11. the melody carried by a particular voice or instrument (voice). *Irrelevant (music).*
    *   12. the part played by a person in bringing about a result (contribution). *Irrelevant (contribution/role).*

4.  **Compare the best candidates (1 and 9):**
    *   Sense 1: "something determined in relation to something that includes it" (component, constituent).
    *   Sense 9: "one of the portions into which something is regarded as divided and which together constitute a whole" (section, division).

    In the context of technical/regulatory documents (EPAR, Summary of Product Characteristics), the term "part" almost always refers to a distinct, labeled section or division. Sense 9, with synonyms like "section" and "division," is the most precise fit for describing a structural component of a document.

5.  **Select the final sense:** Sense 9.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
7. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
13. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the context:** The sentence is: "The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

2.  **Identify the target word and its role:** The target word is "active." It modifies "substance" (pemetrexed).

3.  **Determine the meaning of "active" in this context:** Pemetrexed is a drug. The text refers to the "active substance" and later mentions it is converted into an "active form" that performs a biological function (blocking enzyme activity). In pharmacology, the "active substance" is the component of a drug that produces the intended therapeutic effect.

4.  **Examine the candidate senses:**

    *   1. tending to become more severe or wider in scope (e.g., active tuberculosis) -> Incorrect.
    *   2. engaged in or ready for military or naval operations -> Incorrect.
    *   3. disposed to take action or effectuate change -> Plausible, but perhaps too general.
    *   4. taking part in an activity -> Incorrect.
    *   5. characterized by energetic activity (e.g., an active toddler) -> Incorrect (refers to energy/movement).
    *   6. exerting influence or producing a change or effect (e.g., an active ingredient) -> Highly relevant. This matches the concept of a substance that *works* or *has an effect*.
    *   7. full of activity or engaged in continuous activity (e.g., an active seaport) -> Incorrect.
    *   8. in operation (e.g., keep hope alive) -> Incorrect.
    *   9. (of the sun) characterized by an increased occurrence of sunspots and flares -> Incorrect.
    *   10. expressing that the subject of the sentence has the semantic function of actor -> Grammatical/Linguistic sense. Incorrect.
    *   11. expressing action rather than a state of being (e.g., running water) -> Grammatical/Linguistic sense. Incorrect.
    *   12. (of e.g. volcanos) capable of erupting -> Incorrect.
    *   13. (of e.g. volcanos) erupting or liable to erupt -> Incorrect.
    *   14. engaged in full-time work -> Incorrect.

5.  **Compare the best candidates (3 and 6):**
    *   Sense 3: "disposed to take action or effectuate change."
    *   Sense 6: "exerting influence or producing a change or effect" (Example: an active ingredient).

    The context explicitly uses the phrase "The active substance." In chemistry and medicine, the term "active ingredient" (Sense 6) is the standard technical term for the substance that produces the effect. Sense 6 perfectly captures the meaning of a substance that *exerts influence* or *produces a change* (i.e., the therapeutic effect).

6.  **Conclusion:** Sense 6 is the best fit.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: substance
Target surface form: substance
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=substance%1:03:00:: | definition=the real physical matter of which a person or thing consists | examples=DNA is the substance of our genes
2. sense_key=substance%1:09:01:: | definition=the choicest or most essential or most vital part of some idea or experience | synonyms=kernel, core, center, centre, essence, gist | examples=the gist of the prosecutor's argument; the heart and soul of the Republican Party
3. sense_key=substance%1:09:00:: | definition=the idea that is intended | synonyms=meaning | examples=What is the meaning of this proverb?
4. sense_key=substance%1:27:00:: | definition=material of a particular kind or constitution | examples=the immune response recognizes invading substances
5. sense_key=substance%1:21:00:: | definition=considerable capital (wealth or income) | synonyms=means | examples=he is a man of means
6. sense_key=substance%1:10:00:: | definition=what a communication that is about something is about | synonyms=message, content, subject matter
7. sense_key=substance%1:03:01:: | definition=a particular kind or species of matter with uniform properties | examples=shigella is one of the most toxic substances known to man

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the context:** The sentence is: "The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites."
2.  **Determine the meaning of 'substance' in context:** Here, 'substance' refers to the active chemical component (pemetrexed) within the drug (Alimta). It is a physical, chemical entity that has specific properties (cytotoxic medicine, antimetabolite).
3.  **Examine the candidate senses:**
    *   1. `substance%1:03:00`: "the real physical matter of which a person or thing consists." (Relates to physical composition/matter).
    *   2. `substance%1:09:01`: "the choicest or most essential or most vital part of some idea or experience." (Abstract essence/core).
    *   3. `substance%1:09:00`: "the idea that is intended." (Meaning/intent).
    *   4. `substance%1:27:00`: "material of a particular kind or constitution." (Material/composition).
    *   5. `substance%1:21:00`: "considerable capital (wealth or income)." (Wealth/money).
    *   6. `substance%1:10:00`: "what a communication that is about something is about." (Topic/content).
    *   7. `substance%1:03:01`: "a particular kind or species of matter with uniform properties." (Chemical/physical type of matter).
4.  **Match the context to the senses:**
    *   The context is about a chemical component (pemetrexed) of a medicine.
    *   Sense 1 (physical matter) is plausible, but perhaps too broad.
    *   Sense 2 & 3 (abstract ideas) are incorrect.
    *   Sense 4 (material of a particular kind or constitution) is very close, referring to the chemical nature.
    *   Sense 5 & 6 (wealth/topic) are incorrect.
    *   Sense 7 (a particular kind or species of matter with uniform properties) is highly specific and perfectly describes a chemical compound like pemetrexed.

5.  **Refine the choice between 1, 4, and 7:**
    *   Sense 1: General physical matter (e.g., "water is a substance").
    *   Sense 4: Material of a particular kind (e.g., "wood is a substance").
    *   Sense 7: A particular kind or species of matter with uniform properties (e.g., "pemetrexed is a substance").
    *   Since the context specifies a chemical entity (pemetrexed) that belongs to a specific group (antimetabolites) and has uniform properties, Sense 7 is the most precise fit for a chemical/pharmaceutical context.

6.  **Final Selection:** Sense 7.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "medicine" in the provided context.

Context:
"How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

The target word is "medicine" (the second instance, which is glossed as "a medicine that kills cells that are dividing, such as cancer cells").

Let's analyze the candidate senses:

1. `sense_key=medicine%1:09:00`: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty. (Refers to a field of study/practice, e.g., internal medicine).
2. `sense_key=medicine%1:06:00`: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug. (Refers to a substance/drug).
3. `sense_key=medicine%1:04:00`: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard. (Refers to the profession/field of study).
4. `sense_key=medicine%1:04:02`: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine. (Refers to punishment/remedy).

The context describes pemetrexed as a "cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells)".
Pemetrexed is a substance (a drug/chemical) used in cancer treatment.

*   Sense 1 (Medical specialty): Incorrect. Pemetrexed is not a specialty.
*   Sense 2 (Substance/Drug): Correct. Pemetrexed is a drug/medication. The definition matches: "something that treats or prevents or alleviates the symptoms of disease."
*   Sense 3 (Profession): Incorrect. Pemetrexed is not a profession.
*   Sense 4 (Punishment): Incorrect.

The best fit is Sense 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "medicine" in the provided context.

Context:
"When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

Target word: medicine (specifically the second instance: "a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells)")

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Analysis:
The target phrase is "a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells)".
The definition provided in the context ("that kills cells that are dividing, such as cancer cells") describes a substance used to treat disease (specifically cancer).

Let's evaluate the senses:
1. sense_key=medicine%1:09:00: Refers to a branch of medical science (e.g., cardiology). This is incorrect; the target is a substance.
2. sense_key=medicine%1:06:00: Definition is "something that treats or prevents or alleviates the symptoms of disease." Synonyms include "medication, medicament, medicinal drug." This perfectly matches the description of a cytotoxic substance used in cancer treatment.
3. sense_key=medicine%1:04:00: Refers to the profession/study of medicine (e.g., "studying medicine"). This is incorrect; the target is a substance.
4. sense_key=medicine%1:04:02: Refers to punishment. This is incorrect.

The best fit is sense_key=medicine%1:06:00.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: kill
Target surface form: kills
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=kill%2:35:00:: | definition=cause to die; put to death, usually intentionally or knowingly | examples=This man killed several people when he tried to rob a bank; The farmer killed a pig for the holidays
2. sense_key=kill%2:41:01:: | definition=thwart the passage of | synonyms=shoot down, defeat, vote down, vote out | examples=kill a motion; he shot down the student's proposal
3. sense_key=kill%2:30:08:: | definition=end or extinguish by forceful means | synonyms=stamp out | examples=Stamp out poverty!
4. sense_key=kill%2:42:00:: | definition=be fatal | examples=cigarettes kill; drunken driving kills
5. sense_key=kill%2:39:00:: | definition=be the source of great pain for | examples=These new shoes are killing me!
6. sense_key=kill%2:37:00:: | definition=overwhelm with hilarity, pleasure, or admiration | examples=The comedian was so funny, he was killing me!
7. sense_key=kill%2:35:06:: | definition=hit with so much force as to make a return impossible, in racket games | examples=She killed the ball
8. sense_key=kill%2:35:05:: | definition=hit with great force | examples=He killed the ball
9. sense_key=kill%2:35:02:: | definition=deprive of life | examples=AIDS has killed thousands in Africa
10. sense_key=kill%2:35:01:: | definition=cause the death of, without intention | examples=She was killed in the collision of three cars
11. sense_key=kill%2:34:00:: | definition=drink down entirely | synonyms=toss off, pop, bolt down, belt down, pour down, down | examples=He downed three martinis before dinner; She killed a bottle of brandy that night
12. sense_key=kill%2:30:00:: | definition=mark for deletion, rub off, or erase | synonyms=obliterate, wipe out | examples=kill these lines in the President's speech
13. sense_key=kill%2:30:04:: | definition=tire out completely | examples=The daily stress of her work is killing her
14. sense_key=kill%2:30:03:: | definition=cause to cease operating | examples=kill the engine
15. sense_key=kill%2:30:02:: | definition=destroy a vitally essential quality of or in | examples=Eating artichokes kills the taste of all other foods

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the context:** The sentence is: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells), which belongs to the group antimetabolites."
2.  **Identify the target word and its usage:** The target word is "kills" (from "cytotoxic medicine (a medicine that kills cells...)"). The action is performed by a medicine (pemetrexed) upon cells.
3.  **Determine the meaning of "kills" in this context:** A cytotoxic medicine kills cells. This means it causes the cells to die.
4.  **Examine the candidate senses:**
    *   1. cause to die; put to death, usually intentionally or knowingly (General killing, often intentional).
    *   2. thwart the passage of (Defeat, stop). (Incorrect)
    *   3. end or extinguish by forceful means (Stamp out). (Incorrect)
    *   4. be fatal (Cause death, often passively). (Possible, but usually used with subjects like "cigarettes kill").
    *   5. be the source of great pain for (Annoy). (Incorrect)
    *   6. overwhelm with hilarity, pleasure, or admiration (Amuse). (Incorrect)
    *   7. hit with so much force as to make a return impossible (Racket games). (Incorrect)
    *   8. hit with great force (Sports). (Incorrect)
    *   9. deprive of life (Cause death). (Strong candidate, focuses on the result).
    *   10. cause the death of, without intention (Accidental death). (Incorrect, this is a biological mechanism, not an accident).
    *   11. drink down entirely (Consume). (Incorrect)
    *   12. mark for deletion, rub off, or erase (Delete). (Incorrect)
    *   13. tire out completely (Exhaust). (Incorrect)
    *   14. cause to cease operating (Stop). (Incorrect)
    *   15. destroy a vitally essential quality of or in (Spoil). (Incorrect)
5.  **Compare the best candidates (1, 9, 10):**
    *   The context is biological/medical: a medicine *causes* cells to die.
    *   Sense 1: "cause to die; put to death, usually intentionally or knowingly." This fits the mechanism of a cytotoxic drug.
    *   Sense 9: "deprive of life." This is a very precise description of what a cytotoxic agent does to a cell.
    *   Sense 10: "cause the death of, without intention." While the drug doesn't *intend* to kill the cell, the mechanism is active and targeted, making Sense 1 or 9 more appropriate than the passive/accidental connotation of 10.
6.  **Select the best fit:** Sense 9 ("deprive of life") is highly accurate for describing a substance that causes cells to die. Sense 1 ("cause to die") is also very strong. However, Sense 9 is often used in scientific contexts to describe the action of a substance on a biological entity. Let's re-evaluate the definitions.
    *   Sense 1: Focuses on the act of putting something to death.
    *   Sense 9: Focuses on the result—depriving of life.
    *   Given the context of a *cytotoxic* medicine, the action is fundamentally about causing cellular death. Sense 9 captures this biological outcome most directly.

7.  **Final Check:** "a medicine that kills cells" -> "a medicine that deprives cells of life." This is a perfect match.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cells
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the target word and context:**
    *   Target lemma: cell
    *   Target surface form: cells
    *   Context snippet: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

2.  **Determine the meaning of 'cells' in context:**
    *   The context discusses a "cytotoxic medicine" (a medicine that kills cells).
    *   It specifically mentions "cancer cells."
    *   It later discusses "nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."
    *   The meaning is clearly biological, referring to the fundamental units of life.

3.  **Evaluate the candidate senses:**
    *   1. `cell%1:06:03`: any small compartment (Too general, doesn't fit the biological context of cancer/DNA).
    *   2. `cell%1:03:00`: (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life... (This perfectly matches the biological context: cancer cells, DNA/RNA building blocks).
    *   3. `cell%1:06:00`: a device that delivers an electric current... (Incorrect - electrical/physics).
    *   4. `cell%1:14:00`: a small unit serving as part of or as the nucleus of a larger political movement (Incorrect - political).
    *   5. `cell%1:06:04`: a hand-held mobile radiotelephone... (Incorrect - technology).
    *   6. `cell%1:06:02`: small room in which a monk or nun lives (Incorrect - architectural/religious).
    *   7. `cell%1:06:01`: a room where a prisoner is kept (Incorrect - architectural/legal).

4.  **Select the best sense:**
    *   Sense 2 (`cell%1:03:00`) is the definitive match for the biological usage described (cytotoxic medicine, cancer cells, DNA/RNA).

5.  **Format the output:**
    *   The required output is a JSON object containing the single best sense index.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: divide
Target surface form: dividing
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=divide%2:41:00:: | definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire after World War I
2. sense_key=divide%2:31:00:: | definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven?
3. sense_key=divide%2:42:00:: | definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries
4. sense_key=divide%2:35:00:: | definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated
5. sense_key=divide%2:38:00:: | definition=make a division or separation | synonyms=separate
6. sense_key=divide%2:35:01:: | definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "dividing" (a present participle of "divide") based on the provided context.

Context: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells), which belongs to the group antimetabolites."

Target word: dividing (from divide)

Analysis of the context:
The medicine (pemetrexed) is cytotoxic, meaning it kills cells. It specifically targets cells that are "dividing," such as cancer cells. This refers to the biological process of cell division (mitosis/proliferation).

Analysis of candidate senses:
1. sense_key=divide%2:41:00:: | definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | (Physical separation) - Unlikely.
2. sense_key=divide%2:31:00:: | definition=perform a division | synonyms=fraction | (Mathematical division) - Unlikely.
3. sense_key=divide%2:42:00:: | definition=act as a barrier between; stand between | synonyms=separate | (Separation/barrier) - Unlikely.
4. sense_key=divide%2:35:00:: | definition=come apart | synonyms=separate, part | (Self-separation) - Unlikely.
5. sense_key=divide%2:38:00:: | definition=make a division or separation | synonyms=separate | (Action of separating) - Unlikely.
6. sense_key=divide%2:35:01:: | definition=force, take, or pull apart | synonyms=separate, disunite, part | (Forced separation) - Unlikely.

Wait, none of the provided senses explicitly cover the biological process of cell division (proliferation/replication).

Let's re-examine the relationship between the context and the senses.
The context uses "dividing" in the biological sense: cells that are undergoing division.

If I must choose the *best* fit from the given options, I need to see if any of them can be interpreted metaphorically or broadly enough to cover biological division.

The provided senses are all related to physical or mathematical separation.

*   Sense 1: Separate into parts or portions (e.g., dividing a cake).
*   Sense 2: Perform a division (e.g., 49/7).
*   Sense 3: Act as a barrier.
*   Sense 4: Come apart.
*   Sense 5: Make a division or separation.
*   Sense 6: Force apart.

Since the target word is used in a highly specialized scientific context (cytotoxic medicine targeting proliferating cells), and none of the senses capture "replicate" or "proliferate," there might be an issue with the provided candidate list relative to the context.

However, if I am forced to choose the *closest* sense, I must consider if "cell division" is conceptually related to "separation into parts."

Cell division (mitosis) is fundamentally the process where one cell separates into two (or more) daughter cells. This is a form of separation.

Sense 1: "separate into parts or portions." This is the most general sense of separation/splitting. While it usually implies physical objects (cake, empire), it is the closest conceptual match to the biological process of separation into daughter cells.

Let's assume the intended sense for biological division (proliferation) maps onto the general concept of separation (Sense 1).

If I strictly adhere to the provided definitions and examples, Sense 1 is the only one dealing with splitting into multiple parts.

Conclusion: Sense 1 is the most plausible fit, despite the poor fit of the provided sense list for this specific scientific context.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: body
Target surface form: body
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=body%1:08:00:: | definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
2. sense_key=body%1:14:00:: | definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium; the student body
3. sense_key=body%1:08:02:: | definition=a natural object consisting of a dead animal or person | synonyms=dead body | examples=they found the body in the lake
4. sense_key=body%1:17:00:: | definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. sense_key=body%1:08:01:: | definition=the body excluding the head and neck and limbs | synonyms=torso, trunk | examples=they moved their arms and legs and bodies
6. sense_key=body%1:14:02:: | definition=a collection of particulars considered as a system | examples=a body of law; a body of doctrine
7. sense_key=body%1:07:00:: | definition=the property of holding together and retaining its shape | synonyms=consistency, consistence, eubstance | examples=wool has more body than rayon; when the dough has enough consistency it is ready to bake
8. sense_key=body%1:10:00:: | definition=the central message of a communication | examples=the body of the message was short
9. sense_key=body%1:07:01:: | definition=the main mass of a thing
10. sense_key=body%1:06:01:: | definition=a resonating chamber in a musical instrument (as the body of a violin) | synonyms=soundbox
11. sense_key=body%1:06:00:: | definition=the external structure of a vehicle | examples=the body of the car was badly rusted

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "body" in the given context.

Context: "In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

Target word: body

Analysis of the context:
The sentence discusses a chemical process: "pemetrexed is converted into an active form... in the body." Pemetrexed is a cytotoxic medicine (mentioned earlier in the text) that acts on cells and enzymes involved in DNA/RNA production. This strongly suggests the context is biological/physiological.

Analysis of candidate senses:
1. sense_key=body%1:08:00:: | definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
2. sense_key=body%1:14:00:: | definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium; the student body
3. sense_key=body%1:08:02:: | definition=a natural object consisting of a dead animal or person | synonyms=dead body | examples=they found the body in the lake
4. sense_key=body%1:17:00:: | definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. sense_key=body%1:08:01:: | definition=the body excluding the head and neck and limbs | synonyms=torso, trunk | examples=they moved their arms and legs and bodies
6. sense_key=body%1:14:02:: | definition=a collection of particulars considered as a system | examples=a body of law; a body of doctrine
7. sense_key=body%1:07:00:: | definition=the property of holding together and retaining its shape | synonyms=consistency, consistence, eubstance | examples=wool has more body than rayon; when the dough has enough consistency it is ready to bake
8. sense_key=body%1:10:00:: | definition=the central message of a communication | examples=the body of the message was short
9. sense_key=body%1:07:01:: | definition=the main mass of a thing
10. sense_key=body%1:06:01:: | definition=a resonating chamber in a musical instrument (as the body of a violin) | synonyms=soundbox
11. sense_key=body%1:06:00:: | definition=the external structure of a vehicle | examples=the body of the car was badly rusted

Matching the context ("pemetrexed is converted... in the body") to the senses:
The context refers to the biological system where the drug acts.
Sense 1: "the entire structure of an organism (an animal, plant, or human being)". This perfectly matches the biological context of drug metabolism and action.
Sense 5: "the body excluding the head and neck and limbs". While part of the organism, Sense 1 is the more general and accurate fit for the location of metabolic conversion.

Conclusion: Sense 1 is the best fit.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: convert
Target surface form: converted
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=convert%2:30:00:: | definition=change from one system to another or to a new plan or policy | synonyms=change over | examples=We converted from 220 to 110 Volt
2. sense_key=convert%2:30:03:: | definition=change the nature, purpose, or function of something | examples=convert lead into gold; convert hotels into jails
3. sense_key=convert%2:30:01:: | definition=change religious beliefs, or adopt a religious belief | examples=She converted to Buddhism
4. sense_key=convert%2:30:02:: | definition=exchange or replace with another, usually of the same kind or category | synonyms=change, exchange, commute | examples=Could you convert my dollars into pounds?; He changed his name
5. sense_key=convert%2:30:07:: | definition=cause to adopt a new or different faith | examples=The missionaries converted the Indian population
6. sense_key=convert%2:33:02:: | definition=score an extra point or points after touchdown by kicking the ball through the uprights or advancing the ball into the end zone | examples=Smith converted and his team won
7. sense_key=convert%2:33:01:: | definition=complete successfully | examples=score a penalty shot or free throw
8. sense_key=convert%2:33:00:: | definition=score (a spare)
9. sense_key=convert%2:32:00:: | definition=make (someone) agree, understand, or realize the truth or validity of something | synonyms=win over, convince | examples=He had finally convinced several customers of the advantages of his product
10. sense_key=convert%2:30:09:: | definition=exchange a penalty for a less severe one | synonyms=commute, exchange
11. sense_key=convert%2:30:04:: | definition=change in nature, purpose, or function; undergo a chemical change | examples=The substance converts to an acid

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "converted" (lemma: convert) based on the provided context.

Context: "In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

The word "converted" here describes a chemical process where the substance "pemetrexed" changes into another form ("an active form").

Let's examine the candidate senses:

1. `sense_key=convert%2:30:00`: change from one system to another or to a new plan or policy. (Irrelevant - system/policy change)
2. `sense_key=convert%2:30:03`: change the nature, purpose, or function of something. (Plausible, but perhaps too general)
3. `sense_key=convert%2:30:01`: change religious beliefs, or adopt a religious belief. (Irrelevant - religion)
4. `sense_key=convert%2:30:02`: exchange or replace with another, usually of the same kind or category. (Less likely - implies substitution, not necessarily chemical transformation)
5. `sense_key=convert%2:30:07`: cause to adopt a new or different faith. (Irrelevant - religion)
6. `sense_key=convert%2:33:02`: score an extra point or points after touchdown... (Irrelevant - sports)
7. `sense_key=convert%2:33:01`: complete successfully. (Irrelevant - achievement)
8. `sense_key=convert%2:33:00`: score (a spare). (Irrelevant - sports)
9. `sense_key=convert%2:32:00`: make (someone) agree, understand, or realize the truth or validity of something. (Irrelevant - persuasion)
10. `sense_key=convert%2:30:09`: exchange a penalty for a less severe one. (Irrelevant - legal/sports)
11. `sense_key=convert%2:30:04`: change in nature, purpose, or function; undergo a chemical change. (Highly relevant - describes a chemical transformation, which matches the context: "pemetrexed is converted into an active form").

Sense 11 is the most precise fit, specifically mentioning "undergo a chemical change."

I must return the JSON object with the sense index.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
7. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
13. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the context:** The sentence is: "In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."
2.  **Identify the target word and its role:** The target word is "active." It modifies "form." The form is a chemical entity (a metabolite of pemetrexed).
3.  **Determine the meaning required:** The form is "active" because it performs a function—it "blocks the activity of the enzymes." This implies the form itself possesses functional capability or potency.
4.  **Examine the candidate senses:**
    *   1. tending to become more severe or wider in scope (e.g., active tuberculosis) -> Incorrect.
    *   2. engaged in or ready for military or naval operations -> Incorrect.
    *   3. disposed to take action or effectuate change -> Plausible, relates to capability/function.
    *   4. taking part in an activity -> Incorrect (usually for people/groups).
    *   5. characterized by energetic activity -> Possible, but usually describes living things or processes, not necessarily the chemical potency of a molecule.
    *   6. exerting influence or producing a change or effect (examples: an active ingredient) -> Highly relevant. A drug metabolite that blocks enzymes is an "active ingredient" or has "active" properties.
    *   7. full of activity or engaged in continuous activity -> Incorrect (describes state/busyness).
    *   8. in operation -> Incorrect (usually for systems/machinery).
    *   9. (of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions -> Incorrect.
    *   10. expressing that the subject of the sentence has the semantic function of actor -> Grammatical/linguistic sense. Incorrect.
    *   11. expressing action rather than a state of being -> Grammatical/linguistic sense. Incorrect.
    *   12. (of e.g. volcanos) capable of erupting -> Incorrect.
    *   13. (of e.g. volcanos) erupting or liable to erupt -> Incorrect.
    *   14. engaged in full-time work -> Incorrect.
5.  **Compare the best candidates (3 and 6):**
    *   Sense 3: "disposed to take action or effectuate change." (General capability)
    *   Sense 6: "exerting influence or producing a change or effect" (Specific functional potency, exemplified by "active ingredient").
6.  **Select the best fit:** In pharmacology, when a substance is described as "active," it means it has biological potency—it exerts a specific effect (blocking enzymes). Sense 6, "exerting influence or producing a change or effect," perfectly captures this pharmacological meaning, especially given the example "an active ingredient."
7.  **Final check:** "Pemetrexed is converted into an active form [Sense 6] that blocks the activity of the enzymes." This fits perfectly.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: form
Target surface form: form
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=form%1:10:00:: | definition=the phonological or orthographic sound or appearance of a word that can be used to describe or identify something | synonyms=word form, signifier, descriptor | examples=the inflected forms of a word can be represented by a stem and a list of inflections to be attached
2. sense_key=form%1:09:01:: | definition=a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety | examples=sculpture is a form of art; what kinds of desserts are there?
3. sense_key=form%1:09:00:: | definition=a perceptual structure | synonyms=shape, pattern | examples=the composition presents problems for students of musical form; a visual pattern must include not only objects but the spaces between them
4. sense_key=form%1:07:01:: | definition=any spatial attributes (especially as defined by outline) | synonyms=shape, configuration, contour, conformation | examples=he could barely make out their shapes
5. sense_key=form%1:08:00:: | definition=alternative names for the body of a human being | synonyms=human body, physical body, material body, soma, build, figure | examples=Leonardo studied the human body; he has a strong physique
6. sense_key=form%1:03:00:: | definition=the spatial arrangement of something as distinct from its substance | synonyms=shape | examples=geometry is the mathematical science of shape
7. sense_key=form%1:07:00:: | definition=the visual appearance of something or someone | synonyms=shape, cast | examples=the delicate cast of his features
8. sense_key=form%1:10:01:: | definition=a printed document with spaces in which to write | examples=he filled out his tax form
9. sense_key=form%1:14:02:: | definition=(biology) a group of organisms within a species that differ in trivial ways from similar groups | synonyms=variant, strain, var. | examples=a new strain of microorganisms
10. sense_key=form%1:10:02:: | definition=an arrangement of the elements in a composition or discourse | examples=the essay was in the form of a dialogue; he first sketches the plot in outline form
11. sense_key=form%1:07:03:: | definition=a particular mode in which something is manifested | examples=his resentment took the form of extreme hostility
12. sense_key=form%1:26:00:: | definition=(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary | synonyms=phase | examples=the reaction occurs in the liquid phase of the system
13. sense_key=form%1:14:00:: | definition=a body of students who are taught together | synonyms=class, grade, course | examples=early morning classes are always sleepy
14. sense_key=form%1:07:02:: | definition=an ability to perform well | examples=he was at the top of his form; the team was off form last night
15. sense_key=form%1:06:00:: | definition=a life-size dummy used to display clothes | synonyms=mannequin, manikin, mannikin, manakin
16. sense_key=form%1:06:01:: | definition=a mold for setting concrete | examples=they built elaborate forms for pouring the foundation

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "form" in the given context.

Context: "In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

Target word: form

Analysis of the context:
The context describes a chemical process: a substance (pemetrexed) is converted into an "active form." This active form then interacts biologically (blocks enzyme activity). This suggests a chemical or biological state/structure resulting from a transformation.

Reviewing the candidate senses:

1. sense_key=form%1:10:00:: (phonological/orthographic sound/appearance) - Unlikely in a biological/chemical context.
2. sense_key=form%1:09:01:: (category of things) - Too general.
3. sense_key=form%1:09:00:: (perceptual structure/shape/pattern) - Relates to physical shape, less likely for a chemical state.
4. sense_key=form%1:07:01:: (spatial attributes/shape) - Physical shape, unlikely for a chemical state.
5. sense_key=form%1:08:00:: (alternative names for the body) - Irrelevant.
6. sense_key=form%1:03:00:: (spatial arrangement/shape) - Physical shape, unlikely.
7. sense_key=form%1:07:00:: (visual appearance) - Visual, unlikely for a chemical state.
8. sense_key=form%1:10:01:: (printed document) - Irrelevant.
9. sense_key=form%1:14:02:: (biological group/strain) - Refers to populations of organisms, not a chemical conversion product.
10. sense_key=form%1:10:02:: (arrangement of elements in composition/discourse) - Abstract structure, irrelevant.
11. sense_key=form%1:07:03:: (particular mode in which something is manifested) - This relates to how something appears or exists (e.g., "resentment took the form of hostility"). This is a possibility, referring to a manifestation or state.
12. sense_key=form%1:26:00:: (physical chemistry: distinct state of matter/phase) - This is highly relevant. Chemical conversion often results in a different chemical state or phase (e.g., active metabolite vs. inactive precursor).
13. sense_key=form%1:14:00:: (body of students) - Irrelevant.
14. sense_key=form%1:07:02:: (ability to perform well) - Irrelevant.
15. sense_key=form%1:06:00:: (life-size dummy) - Irrelevant.
16. sense_key=form%1:06:01:: (mold for setting concrete) - Irrelevant.

Comparing Sense 11 and Sense 12:
Sense 11: "a particular mode in which something is manifested" (e.g., abstract concept manifesting as a physical action).
Sense 12: "(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary" (i.e., a chemical/physical state).

In the context, "pemetrexed is converted into an active form." Since pemetrexed is a cytotoxic medicine and the process involves chemical conversion leading to an active biological agent, the term "form" most accurately refers to a specific chemical state or metabolite (a distinct chemical entity/state). Sense 12, relating to physical chemistry and distinct states of matter/substances, is the most precise fit for a chemical conversion product in a biological context.

Therefore, sense_key=form%1:26:00 is the best choice.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: block
Target surface form: blocks
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=block%2:35:00:: | definition=render unsuitable for passage | synonyms=barricade, blockade, stop, block off, block up, bar | examples=block the way; barricade the streets
2. sense_key=block%2:41:00:: | definition=hinder or prevent the progress or accomplishment of | synonyms=obstruct, blockade, hinder, stymie, stymy, embarrass | examples=His brother blocked him at every turn
3. sense_key=block%2:41:01:: | definition=stop from happening or developing | synonyms=stop, halt, kibosh | examples=Block his election; Halt the process
4. sense_key=block%2:32:00:: | definition=interfere with or prevent the reception of signals | synonyms=jam | examples=Jam the Voice of America; block the signals emitted by this station
5. sense_key=block%2:41:03:: | definition=run on a block system | examples=block trains
6. sense_key=block%2:39:05:: | definition=interrupt the normal function of by means of anesthesia | examples=block a nerve; block a muscle
7. sense_key=block%2:39:00:: | definition=shut out from view or get in the way so as to hide from sight | synonyms=obstruct | examples=The thick curtain blocked the action on the stage; The trees obstruct my view of the mountains
8. sense_key=block%2:35:03:: | definition=stamp or emboss a title or design on a book with a block | examples=block the book cover
9. sense_key=block%2:35:02:: | definition=obstruct | synonyms=stuff, lug, choke up | examples=My nose is all stuffed; Her arteries are blocked
10. sense_key=block%2:35:12:: | definition=block passage through | synonyms=obstruct, obturate, impede, occlude, jam, close up | examples=obstruct the path
11. sense_key=block%2:35:06:: | definition=support, secure, or raise with a block | examples=block a plate for printing; block the wheels of a car
12. sense_key=block%2:33:00:: | definition=impede the movement of (an opponent or a ball) | synonyms=parry, deflect | examples=block an attack
13. sense_key=block%2:31:00:: | definition=be unable to remember | synonyms=forget, blank out, draw a blank | examples=I'm drawing a blank; You are blocking the name of your first wife!
14. sense_key=block%2:30:01:: | definition=shape by using a block | examples=Block a hat; block a garment
15. sense_key=block%2:30:00:: | definition=shape into a block or blocks | examples=block the graphs so one can see the results clearly
16. sense_key=block%2:30:02:: | definition=prohibit the conversion or use of (assets) | synonyms=freeze, immobilize, immobilise | examples=Blocked funds; Freeze the assets of this hostile government

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the context:** The sentence is: "In the body, pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."
2.  **Determine the meaning of 'blocks' in this context:** Pemetrexed (a cytotoxic medicine) acts on enzymes. It "blocks the activity" of these enzymes. This means it prevents the enzymes from functioning or carrying out their normal process (producing nucleotides).
3.  **Examine the candidate senses for relevance:**

    *   1. render unsuitable for passage (barricade, stop, block off) - Focuses on physical passage. Less relevant to enzyme activity.
    *   2. hinder or prevent the progress or accomplishment of (obstruct, hinder, stymie) - Highly relevant. Preventing enzyme activity is hindering its progress/accomplishment.
    *   3. stop from happening or developing (stop, halt, kibosh) - Highly relevant. Preventing a chemical process (nucleotide production) from happening.
    *   4. interfere with or prevent the reception of signals (jam) - Specific to signals/radio waves. Not relevant.
    *   5. run on a block system - Irrelevant.
    *   6. interrupt the normal function of by means of anesthesia - Specific to medical/anesthesia context. While related to function, the context is chemical inhibition, not nerve blocking.
    *   7. shut out from view or get in the way so as to hide from sight (obstruct) - Focuses on visual obstruction. Not relevant.
    *   8. stamp or emboss a title or design on a book - Irrelevant.
    *   9. obstruct (stuff, lug, choke up) - Often related to physical blockage (e.g., arteries). Possible, but perhaps too physical for enzyme inhibition.
    *   10. block passage through (obstruct, obturate, impede, occlude, jam, close up) - Focuses on physical passage/flow. Relevant if the enzyme activity is viewed as a flow, but perhaps too narrow.
    *   11. support, secure, or raise with a block - Irrelevant.
    *   12. impede the movement of (an opponent or a ball) - Specific to sports/physical movement. Not relevant.
    *   13. be unable to remember - Irrelevant.
    *   14. shape by using a block - Irrelevant.
    *   15. shape into a block or blocks - Irrelevant.
    *   16. prohibit the conversion or use of (assets) - Financial/legal context. Not relevant.

4.  **Compare the best candidates (2 and 3):**
    *   Sense 2: "hinder or prevent the progress or accomplishment of" (Synonyms: obstruct, hinder, stymie). This fits well with inhibiting a biological process.
    *   Sense 3: "stop from happening or developing" (Synonyms: stop, halt, kibosh). This is also a very strong fit, as the drug stops the production of nucleotides.

5.  **Refine the choice:** The drug *blocks the activity* of the enzymes. This is a functional inhibition.
    *   Sense 2 emphasizes *hindering progress*.
    *   Sense 3 emphasizes *stopping from happening*.
    In biochemistry, inhibiting an enzyme's activity is fundamentally stopping the reaction from proceeding or developing. Sense 3 ("stop from happening or developing") captures this cessation of function most directly and broadly, encompassing the idea of preventing the process (nucleotide production) from occurring. Sense 2 is slightly more focused on the *process* being hindered, while Sense 3 focuses on the *outcome* being stopped. Given the context of chemical inhibition, Sense 3 is the most precise description of the mechanism.

6.  **Final Selection:** Sense 3.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: involved
Target surface form: involved
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=involved%3:00:00:: | definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved; the problems involved
2. sense_key=involved%5:00:00:encumbered:00 | definition=entangled or hindered as if e.g. in mire | synonyms=mired | examples=the difficulties in which the question is involved; brilliant leadership mired in details and confusion
3. sense_key=involved%5:00:00:attached:01 | definition=emotionally involved
4. sense_key=involved%5:00:00:complex:00 | definition=highly complex or intricate and occasionally devious; ; ; ; ; ; ; ; - Sir Walter Scott | synonyms=Byzantine, convoluted, knotty, tangled, tortuous | examples=the Byzantine tax structure; Byzantine methods for holding on to his chairmanship
5. sense_key=involved%5:00:00:enclosed:00 | definition=enveloped | examples=a castle involved in mist; the difficulties in which the question is involved

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{
  "sense_index": 1
}
```

content:
```json
{
  "sense_index": 1
}
```

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "involved" in the given context.

Context: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

Target word: involved

Candidate senses:
1. sense_key=involved%3:00:00:: | definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved; the problems involved
2. sense_key=involved%5:00:00:encumbered:00 | definition=entangled or hindered as if e.g. in mire | synonyms=mired | examples=the difficulties in which the question is involved; brilliant leadership mired in details and confusion
3. sense_key=involved%5:00:00:attached:01 | definition=emotionally involved
4. sense_key=involved%5:00:00:complex:00 | definition=highly complex or intricate and occasionally devious; ; ; ; ; ; ; ; - Sir Walter Scott | synonyms=Byzantine, convoluted, knotty, tangled, tortuous | examples=the Byzantine tax structure; Byzantine methods for holding on to his chairmanship
5. sense_key=involved%5:00:00:enclosed:00 | definition=enveloped | examples=a castle involved in mist; the difficulties in which the question is involved

Analysis:
The sentence states that pemetrexed blocks the activity of enzymes that are "involved in producing nucleotides."
Enzymes are biological catalysts. When an enzyme is "involved in producing nucleotides," it means the enzyme participates in the biochemical process of nucleotide synthesis.

Let's evaluate the senses:

1. **sense_key=involved%3:00:00::** definition=connected by participation or association or use. This perfectly matches the idea of an enzyme participating in a chemical process (producing nucleotides).
2. **sense_key=involved%5:00:00:encumbered:00** definition=entangled or hindered. This suggests difficulty or being stuck, which is irrelevant to an enzyme's function.
3. **sense_key=involved%5:00:00:attached:01** definition=emotionally involved. This is clearly incorrect in a biological/chemical context.
4. **sense_key=involved%5:00:00:complex:00** definition=highly complex or intricate. While the process might be complex, the word "involved" here describes the enzyme's role, not the complexity of the enzyme itself or the process (though it relates to the process). Sense 1 is a much more direct fit for describing a functional role.
5. **sense_key=involved%5:00:00:enclosed:00** definition=enveloped. This is incorrect.

Conclusion: Sense 1, meaning "connected by participation or association or use," is the most accurate description of an enzyme that is part of a metabolic pathway.

The required output format is a JSON object with the sense index. Sense 1 corresponds to index 1 in the list provided.