[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: treatment
Target surface form: Treatment
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. <t>Treatment</t> should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=treatment%1:04:00:: | definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) | synonyms=intervention
2. sense_key=treatment%1:04:01:: | definition=the management of someone or something | synonyms=handling | examples=the handling of prisoners; the treatment of water sewage
3. sense_key=treatment%1:07:00:: | definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture
4. sense_key=treatment%1:10:00:: | definition=an extended communication (often interactive) dealing with some particular topic | synonyms=discussion, discourse | examples=the book contains an excellent discussion of modal logic; his treatment of the race question is badly biased

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "Treatment" based on the provided context.

Context analysis:
The text discusses a drug (Alimta), its administration (intravenous infusion, dose calculation), side effects, and medical protocols (corticosteroid, folic acid, cisplatin, anti-emetic medicine).
The specific sentence containing the target word is: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects."

The context is entirely medical, focusing on the administration and management of chemotherapy (Alimta).

Candidate senses:
1. sense_key=treatment%1:04:00:: | definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) | synonyms=intervention
2. sense_key=treatment%1:04:01:: | definition=the management of someone or something | synonyms=handling | examples=the handling of prisoners; the treatment of water sewage
3. sense_key=treatment%1:07:00:: | definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture
4. sense_key=treatment%1:10:00:: | definition=an extended communication (often interactive) dealing with some particular topic | synonyms=discussion, discourse | examples=the book contains an excellent discussion of modal logic; his treatment of the race question is badly biased

Evaluation:
*   Sense 3 (artistic manner) and Sense 4 (communication/discussion) are clearly irrelevant as the context is medical.
*   Sense 1 (care provided to improve a situation, especially medical procedures) fits perfectly. The context discusses delaying or discontinuing the medical care/procedure (Alimta administration) if the patient's condition (abnormal blood counts) is poor.
*   Sense 2 (the management of someone or something) is broader. While medical treatment is a form of management, Sense 1 is more specific and precise, focusing on the *care provided* (the medical intervention itself), which aligns better with the discussion of drug administration and side effects.

Conclusion: Sense 1 is the best fit.

Mapping to the required output format:
Sense 1 corresponds to index 1.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: delay
Target surface form: delayed
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be <t>delayed</t> or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=delay%2:30:00:: | definition=cause to be slowed down or delayed | synonyms=detain, hold up | examples=Traffic was delayed by the bad weather; she delayed the work that she didn't want to perform
2. sense_key=delay%2:42:00:: | definition=act later than planned, scheduled, or required | examples=Don't delay your application to graduate school or else it won't be considered
3. sense_key=delay%2:30:01:: | definition=stop or halt | synonyms=stay, detain | examples=Please stay the bloodshed!
4. sense_key=delay%2:30:05:: | definition=slow the growth or development of | synonyms=check, retard | examples=The brain damage will retard the child's language development

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{
  "sense_index": 2
}
```

finish_reason: stop

content:
```json
{
  "sense_index": 2
}
```

role: assistant

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "delayed" (past participle of "delay") based on the provided context.

Context: "Treatment should be <t>delayed</t> or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects."

Target word: delayed (adjective/past participle modifying "Treatment")

Candidate senses:
1. sense_key=delay%2:30:00:: | definition=cause to be slowed down or delayed | synonyms=detain, hold up | examples=Traffic was delayed by the bad weather; she delayed the work that she didn't want to perform
2. sense_key=delay%2:42:00:: | definition=act later than planned, scheduled, or required | examples=Don't delay your application to graduate school or else it won't be considered
3. sense_key=delay%2:30:01:: | definition=stop or halt | synonyms=stay, detain | examples=Please stay the bloodshed!
4. sense_key=delay%2:30:05:: | definition=slow the growth or development of | synonyms=check, retard | examples=The brain damage will retard the child's language development

Analysis of the context:
The context discusses medical treatment (Alimta) and conditions under which the treatment should be modified: "in patients whose blood counts are abnormal or who have certain other side effects."
The options for modification are: "delayed," "discontinued," or "the dose reduced."

If treatment is delayed, it means it is postponed until the patient's condition improves or the side effects are managed. This aligns with the idea of being held up or postponed from the original schedule.

Evaluating the senses:
1. sense_key=delay%2:30:00: "cause to be slowed down or delayed." This fits perfectly. If the treatment is delayed, it is slowed down from its intended schedule due to adverse effects. Synonyms: detain, hold up.
2. sense_key=delay%2:42:00: "act later than planned, scheduled, or required." This is also a very strong fit, focusing on the temporal aspect of postponement.
3. sense_key=delay%2:30:01: "stop or halt." While delaying can lead to stopping, the context offers "discontinued" as a separate option. Delaying is less absolute than halting/stopping.
4. sense_key=delay%2:30:05: "slow the growth or development of." This is clearly about biological/developmental processes (like growth or learning) and does not fit the context of postponing a medical procedure.

Comparing Sense 1 and Sense 2:
Sense 1: "cause to be slowed down or delayed." (Focus on the process of slowing/holding up)
Sense 2: "act later than planned, scheduled, or required." (Focus on the temporal outcome of postponement)

In the medical context ("Treatment should be delayed... in patients whose blood counts are abnormal"), the meaning is that the scheduled treatment must be postponed until the patient is stable. Both senses capture this. However, Sense 1's definition ("cause to be slowed down or delayed") is broader and encompasses the idea of postponement due to an external factor (the abnormal blood counts/side effects), which is the core meaning here. Sense 2 is very specific to scheduling/planning.

Let's re-examine the provided examples for Sense 1: "Traffic was delayed by the bad weather; she delayed the work that she didn't want to perform." This covers both external forces (weather) and internal reluctance (work).
Let's re-examine the provided examples for Sense 2: "Don't delay your application to graduate school or else it won't be considered." This is purely about missing a deadline.

The context is about a medical necessity causing a postponement. Sense 1 ("cause to be slowed down or delayed") seems the most robust fit for a medical intervention being held up due to patient status.

Wait, I must choose the single best indexed sense. Let's look closely at the definitions again.
Sense 1: cause to be slowed down or delayed.
Sense 2: act later than planned, scheduled, or required.

When a medical treatment is delayed because of abnormal blood counts, it is being postponed from its scheduled time. This is precisely what Sense 2 describes ("act later than planned, scheduled, or required"). While Sense 1 is technically correct, Sense 2 captures the specific temporal nature of the decision (postponing a scheduled event) most accurately in this clinical setting.

Let's stick with Sense 2 as the most precise description of postponing a scheduled medical procedure.

Final check:
Context: Treatment should be delayed (postponed) due to side effects.
Sense 2: act later than planned, scheduled, or required. (Perfect match for postponing a scheduled treatment).

The required output format is a JSON object with the sense index.
Sense 2 corresponds to index 2.

currency: USD

source: unavailable


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: discontinue
Target surface form: discontinued
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or <t>discontinued</t>, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=discontinue%2:42:00:: | definition=put an end to a state or an activity | synonyms=stop, cease, give up, quit, lay off | examples=Quit teasing your little brother
2. sense_key=discontinue%2:42:01:: | definition=come to or be at an end | examples=the support from our sponsoring agency will discontinue after March 31
3. sense_key=discontinue%2:30:00:: | definition=prevent completion | synonyms=break, break off, stop | examples=stop the project; break off the negotiations

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the word "discontinued" (past participle of "discontinue") based on the provided context.

Context: "Treatment should be delayed or <t>discontinued</t>, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects."

Target word: discontinued (meaning the treatment was stopped/ended).

Candidate Senses:
1. sense_key=discontinue%2:42:00:: | definition=put an end to a state or an activity | synonyms=stop, cease, give up, quit, lay off | examples=Quit teasing your little brother
2. sense_key=discontinue%2:42:01:: | definition=come to or be at an end | examples=the support from our sponsoring agency will discontinue after March 31
3. sense_key=discontinue%2:30:00:: | definition=prevent completion | synonyms=break, break off, stop | examples=stop the project; break off the negotiations

Analysis:
The context discusses medical treatment ("Treatment should be delayed or discontinued..."). The action of discontinuing refers to stopping the ongoing treatment due to adverse effects (abnormal blood counts or side effects).

1. sense_key=discontinue%2:42:00: "put an end to a state or an activity" (synonyms: stop, cease, give up, quit). This fits perfectly. Stopping a treatment is putting an end to an activity.
2. sense_key=discontinue%2:42:01: "come to or be at an end." This usually applies to things that naturally finish (like support ending after a date). While treatment ends, the active choice here is to *stop* it prematurely due to medical reasons, making sense 1 a better fit for the active decision/action.
3. sense_key=discontinue%2:30:00: "prevent completion" (synonyms: break, break off, stop). This is also relevant, as the treatment is prevented from completing. However, sense 1 ("put an end to a state or an activity") is a broader and more direct description of the action taken (stopping the activity/treatment).

Comparing 1 and 3:
Sense 1: Put an end to an activity (Treatment -> activity).
Sense 3: Prevent completion (Treatment -> activity that fails to complete).

In the context of medical protocols, "discontinued" means the activity (treatment) is stopped. Sense 1 captures this cessation of activity most accurately.

Therefore, sense_key=discontinue%2:42:00 is the best fit.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: dose
Target surface form: dose
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the <t>dose</t> reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=dose%1:06:00:: | definition=a measured portion of medicine taken at any one time | synonyms=dosage
2. sense_key=dose%1:23:00:: | definition=the quantity of an active agent (substance or radiation) taken in or absorbed at any one time | synonyms=dosage
3. sense_key=dose%1:26:00:: | definition=a communicable infection transmitted by sexual intercourse or genital contact | synonyms=venereal disease, VD, venereal infection, social disease, Cupid's itch, Cupid's disease
4. sense_key=dose%1:06:01:: | definition=street name for lysergic acid diethylamide | synonyms=acid, back breaker, battery-acid, dot, Elvis, loony toons

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the context:** The text discusses a chemotherapy drug (Alimta), its administration, side effects, and treatment protocols. Key phrases include: "anticancer chemotherapy," "recommended dose of Alimta is 500 mg," "intravenous infusion," "cisplatin dose," and "the <t>dose</t> reduced."

2.  **Analyze the target word:** The target word is "dose."

3.  **Evaluate the candidate senses:**
    *   **Sense 1 (dose%1:06:00):** "a measured portion of medicine taken at any one time." Synonyms: dosage. This fits the context perfectly (e.g., "recommended dose of Alimta," "cisplatin dose").
    *   **Sense 2 (dose%1:23:00):** "the quantity of an active agent (substance or radiation) taken in or absorbed at any one time." Synonyms: dosage. This is highly specific and technical, but essentially synonymous with Sense 1 in this medical context.
    *   **Sense 3 (dose%1:26:00):** "a communicable infection transmitted by sexual intercourse or genital contact." Synonyms: venereal disease, VD. This is irrelevant to the medical treatment context.
    *   **Sense 4 (dose%1:06:01):** "street name for lysergic acid diethylamide." Synonyms: acid, back breaker. This is irrelevant to the medical treatment context.

4.  **Compare relevant senses (1 and 2):** Both Sense 1 and Sense 2 refer to the quantity of medicine taken.
    *   Sense 1: "a measured portion of medicine taken at any one time." (General definition)
    *   Sense 2: "the quantity of an active agent (substance or radiation) taken in or absorbed at any one time." (More technical, focusing on active agents/radiation)

    The context deals with chemotherapy (active agents) and specific measurements (500 mg). Sense 2 is slightly more precise for the scientific/medical context of chemotherapy, but Sense 1 is also extremely accurate and perhaps more accessible. Since the context is highly technical (chemotherapy, mg, active agent), Sense 2 captures the nuance of "active agent" better than the general "medicine" in Sense 1. However, let's re-examine the relationship. Sense 1 is a subset or a common usage of Sense 2. Given the options, both are strong.

    Let's check the provided glosses again.
    Sense 1: "a measured portion of medicine taken at any one time"
    Sense 2: "the quantity of an active agent (substance or radiation) taken in or absorbed at any one time"

    Since Alimta is an anticancer chemotherapy drug, it is an "active agent." Sense 2 is the most precise fit for the scientific nature of the text.

5.  **Final Selection:** Sense 2 is the best fit.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: reduce
Target surface form: reduced
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose <t>reduced</t>, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=reduce%2:30:00:: | definition=cut down on; make a reduction in | synonyms=cut down, cut back, trim, trim down, trim back, cut | examples=reduce your daily fat intake; The employer wants to cut back health benefits
2. sense_key=reduce%2:30:06:: | definition=make less complex | examples=reduce a problem to a single question
3. sense_key=reduce%2:41:00:: | definition=bring to humbler or weaker state or condition | examples=He reduced the population to slavery
4. sense_key=reduce%2:40:04:: | definition=simplify the form of a mathematical equation of expression by substituting one term for another
5. sense_key=reduce%2:37:00:: | definition=lower in grade or rank or force somebody into an undignified situation | examples=She reduced her niece to a servant
6. sense_key=reduce%2:30:11:: | definition=be the essential element | synonyms=come down, boil down | examples=The proposal boils down to a compromise
7. sense_key=reduce%2:30:05:: | definition=reduce in size; reduce physically | synonyms=shrink | examples=Hot water will shrink the sweater; Can you shrink this image?
8. sense_key=reduce%2:40:00:: | definition=lessen and make more modest | examples=reduce one's standard of living
9. sense_key=reduce%2:30:04:: | definition=make smaller | synonyms=scale down | examples=reduce an image
10. sense_key=reduce%2:30:03:: | definition=to remove oxygen from a compound, or cause to react with hydrogen or form a hydride, or to undergo an increase in the number of electrons | synonyms=deoxidize, deoxidise
11. sense_key=reduce%2:30:01:: | definition=narrow or limit | synonyms=tighten | examples=reduce the influx of foreigners
12. sense_key=reduce%2:41:03:: | definition=put down by force or intimidation | synonyms=repress, quash, keep down, subdue, subjugate | examples=The government quashes any attempt of an uprising; China keeps down her dissidents very efficiently
13. sense_key=reduce%2:35:00:: | definition=undergo meiosis | examples=The cells reduce
14. sense_key=reduce%2:35:01:: | definition=reposition (a broken bone after surgery) back to its normal site
15. sense_key=reduce%2:30:12:: | definition=destress and thus weaken a sound when pronouncing it
16. sense_key=reduce%2:30:08:: | definition=reduce in scope while retaining essential elements | synonyms=abridge, foreshorten, abbreviate, shorten, cut, contract | examples=The manuscript must be shortened
17. sense_key=reduce%2:30:10:: | definition=be cooked until very little liquid is left | synonyms=boil down, decoct, concentrate | examples=The sauce should reduce to one cup
18. sense_key=reduce%2:30:02:: | definition=cook until very little liquid is left | synonyms=boil down, concentrate | examples=The cook reduced the sauce by boiling it for a long time
19. sense_key=reduce%2:30:09:: | definition=lessen the strength or flavor of a solution or mixture | synonyms=dilute, thin, thin out, cut | examples=cut bourbon
20. sense_key=reduce%2:29:00:: | definition=take off weight | synonyms=melt off, lose weight, slim, slenderize, thin, slim down

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "reduced" (past participle of "reduce") based on the provided context.

Context: "Treatment should be delayed or discontinued, or the dose <t>reduced</t>, in patients whose blood counts are abnormal or who have certain other side effects."

Target word: reduced (dose reduced)
Lemma: reduce

The context indicates that the dose of the drug (Alimta) might be lowered if the patient experiences adverse effects (abnormal blood counts or side effects).

I need to examine the candidate senses for "reduce" and find the one that matches "reducing a dose."

1. sense_key=reduce%2:30:00:: | definition=cut down on; make a reduction in | synonyms=cut down, cut back, trim, trim down, trim back, cut | examples=reduce your daily fat intake; The employer wants to cut back health benefits
    * This sense relates to making a reduction in quantity or amount. This fits perfectly with reducing a dose.

2. sense_key=reduce%2:30:06:: | definition=make less complex | examples=reduce a problem to a single question
    * Not relevant (complexity).

3. sense_key=reduce%2:41:00:: | definition=bring to humbler or weaker state or condition | examples=He reduced the population to slavery
    * Too strong/social context.

4. sense_key=reduce%2:40:04:: | definition=simplify the form of a mathematical equation of expression by substituting one term for another
    * Not relevant (math).

5. sense_key=reduce%2:37:00:: | definition=lower in grade or rank or force somebody into an undignified situation | examples=She reduced her niece to a servant
    * Not relevant (social status).

6. sense_key=reduce%2:30:11:: | definition=be the essential element | synonyms=come down, boil down | examples=The proposal boils down to a compromise
    * Not relevant (essence).

7. sense_key=reduce%2:30:05:: | definition=reduce in size; reduce physically | synonyms=shrink | examples=Hot water will shrink the sweater; Can you shrink this image?
    * Possible, but sense 1 is more general and fits "dose" better than just physical size.

8. sense_key=reduce%2:40:00:: | definition=lessen and make more modest | examples=reduce one's standard of living
    * More about lifestyle/standards, less about dosage.

9. sense_key=reduce%2:30:04:: | definition=make smaller | synonyms=scale down | examples=reduce an image
    * Similar to 7, but sense 1 is better for abstract quantities like doses.

10. sense_key=reduce%2:30:03:: | definition=to remove oxygen from a compound, or cause to react with hydrogen or form a hydride, or to undergo an increase in the number of electrons | synonyms=deoxidize, deoxidise
    * Not relevant (chemistry).

11. sense_key=reduce%2:30:01:: | definition=narrow or limit | synonyms=tighten | examples=reduce the influx of foreigners
    * Related to limiting, but sense 1 (cut down on) is a better fit for dosage adjustment.

12. sense_key=reduce%2:41:03:: | definition=put down by force or intimidation | synonyms=repress, quash, keep down, subdue, subjugate | examples=The government quashes any attempt of an uprising; China keeps down her dissidents very efficiently
    * Not relevant (force).

13. sense_key=reduce%2:35:00:: | definition=undergo meiosis | examples=The cells reduce
    * Not relevant (biology).

14. sense_key=reduce%2:35:01:: | definition=reposition (a broken bone after surgery) back to its normal site
    * Not relevant (medical procedure, but not dose reduction).

15. sense_key=reduce%2:30:12:: | definition=destress and thus weaken a sound when pronouncing it
    * Not relevant (phonetics).

16. sense_key=reduce%2:30:08:: | definition=reduce in scope while retaining essential elements | synonyms=abridge, foreshorten, abbreviate, shorten, cut, contract | examples=The manuscript must be shortened
    * This is about shortening content (like a manuscript), not necessarily lowering the quantity of a dose.

17. sense_key=reduce%2:30:10:: | definition=be cooked until very little liquid is left | synonyms=boil down, decoct, concentrate | examples=The sauce should reduce to one cup
    * Not relevant (cooking).

18. sense_key=reduce%2:30:02:: | definition=cook until very little liquid is left | synonyms=boil down, concentrate | examples=The cook reduced the sauce by boiling it for a long time
    * Not relevant (cooking).

19. sense_key=reduce%2:30:09:: | definition=lessen the strength or flavor of a solution or mixture | synonyms=dilute, thin, thin out, cut | examples=cut bourbon
    * This is about dilution/weakening, which is a type of reduction, but sense 1 is broader and covers the general concept of lowering the amount/dose.

20. sense_key=reduce%2:29:00:: | definition=take off weight | synonyms=melt off, lose weight, slim, slenderize, thin, slim down
    * Not relevant (weight loss).

The most appropriate sense is Sense 1: "cut down on; make a reduction in." This perfectly describes reducing a drug dose.

Sense 1: reduce%2:30:00:: | definition=cut down on; make a reduction in | synonyms=cut down, cut back, trim, trim down, trim back, cut | examples=reduce your daily fat intake; The employer wants to cut back health benefits


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in <t>patients</t> whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{
  "sense_index": 1
}
```

content:
```json
{
  "sense_index": 1
}
```

reasoning_content:
The user wants me to perform Word Sense Disambiguation (WSD) for the target word "patients" (plural of "patient") based on the provided context.

Context analysis:
The text discusses the administration and use of a drug (Alimta) for cancer treatment. It mentions:
1. Dosage calculation based on patient's height and weight.
2. Patients taking corticosteroids and folic acid.
3. Treatment being delayed or discontinued in patients whose blood counts are abnormal or who have certain other side effects.
4. Alimta not being recommended for use in patients with moderate or severe kidney problems.

The word "patients" clearly refers to individuals receiving medical treatment for cancer.

Candidate senses:
1. `sense_key=patient%1:18:00`: definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. `sense_key=patient%1:10:00`: definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Evaluation:
Sense 1 defines "patient" as "a person who requires medical care." This perfectly matches the context (people undergoing chemotherapy treatment).
Sense 2 defines "patient" as a grammatical/semantic role (the recipient of an action). While the patients *are* the semantic patients in the sentences, the intended meaning of the *word* "patient" in this context is the person, not the grammatical role itself.

Conclusion: Sense 1 is the correct sense.

The required output format is a JSON object with the sense index. Since the provided senses are numbered 1 and 2, I must choose the index corresponding to Sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: blood_count
Target surface form: blood counts
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose <t>blood counts</t> are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=blood_count%1:23:00:: | definition=the number of red and white corpuscles in a blood sample
2. sense_key=blood_count%1:04:00:: | definition=the act of estimating the number of red and white corpuscles in a blood sample

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{
  "sense_index": 1
}
```

reasoning_content:
The user wants me to perform Word Sense Disambiguation (WSD) for the phrase "blood counts" in the given context.
The target lemma is `blood_count`.
The context is: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose <t>blood counts</t> are abnormal or who have certain other side effects."

Candidate senses:
1. `sense_key=blood_count%1:23:00`: definition=the number of red and white corpuscles in a blood sample
2. `sense_key=blood_count%1:04:00`: definition=the act of estimating the number of red and white corpuscles in a blood sample

Analysis of the context:
The sentence discusses when treatment should be delayed or discontinued. This is based on patients whose "blood counts are abnormal."
When medical professionals refer to "abnormal blood counts," they are referring to the *results* of a blood test—specifically, the measured levels (numbers) of different blood components (like red and white corpuscles).

Comparing the senses:
Sense 1: "the number of red and white corpuscles in a blood sample." This refers to the measured quantity/result.
Sense 2: "the act of estimating the number of red and white corpuscles in a blood sample." This refers to the procedure (the counting itself).

In the phrase "blood counts are abnormal," the subject ("blood counts") must be a measurable quantity or state, not the action of measuring. If the *act* of counting were abnormal, the phrasing would likely be different (e.g., "abnormal counting procedure"). Since the abnormality relates to the patient's health status requiring treatment modification, it must refer to the measured values.

Therefore, Sense 1 is the correct interpretation.

The required output format is a JSON object with the sense index.
Sense 1 corresponds to index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: abnormal
Target surface form: abnormal
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are <t>abnormal</t> or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=abnormal%3:00:00:: | definition=not normal; not typical or usual or regular or conforming to a norm | synonyms=unnatural | examples=abnormal powers of concentration; abnormal amounts of rain
2. sense_key=abnormal%3:00:03:: | definition=departing from the normal in e.g. intelligence and development | examples=they were heartbroken when they learned their child was abnormal; an abnormal personality
3. sense_key=abnormal%5:00:00:immoderate:00 | definition=much greater than the normal | examples=abnormal profits; abnormal ambition

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{
  "sense_index": 1
}
```

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "abnormal" in the given context.

Context: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are <t>abnormal</t> or who have certain other side effects."

Target word: abnormal
Candidate senses:
1. sense_key=abnormal%3:00:00:: | definition=not normal; not typical or usual or regular or conforming to a norm | synonyms=unnatural | examples=abnormal powers of concentration; abnormal amounts of rain
2. sense_key=abnormal%3:00:03:: | definition=departing from the normal in e.g. intelligence and development | examples=they were heartbroken when they learned their child was abnormal; an abnormal personality
3. sense_key=abnormal%5:00:00:immoderate:00 | definition=much greater than the normal | examples=abnormal profits; abnormal ambition

Analysis:
The word "abnormal" modifies "blood counts". Blood counts (like white blood cell count, hemoglobin level, etc.) are measured values that are expected to fall within a normal range.
If the blood counts are "abnormal," it means they are outside the expected, typical, or normal range.

Let's evaluate the senses:
1. sense_key=abnormal%3:00:00: Definition is "not normal; not typical or usual or regular or conforming to a norm." This perfectly matches the context of medical test results (blood counts).
2. sense_key=abnormal%3:00:03: Definition relates to intelligence and development (e.g., a child). This is irrelevant to blood counts.
3. sense_key=abnormal%5:00:00:immoderate:00: Definition is "much greater than the normal." While some abnormal counts might be too high, this sense is too specific (immoderate/excessive) and doesn't cover the general meaning of being outside the normal range (which could be too low or too high). Sense 1 is broader and more accurate for general medical deviation.

Conclusion: Sense 1 is the best fit, as it means "not normal" or "not typical," which is exactly what an abnormal blood count signifies.

The required output format is a JSON object with the sense index. Sense 1 corresponds to index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: have
Target surface form: have
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who <t>have</t> certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=have%2:40:00:: | definition=have or possess, either in a concrete or an abstract sense | synonyms=have got, hold | examples=She has $1,000 in the bank; He has got two beautiful daughters
2. sense_key=have%2:42:00:: | definition=have as a feature | synonyms=feature | examples=This restaurant features the most famous chefs in France
3. sense_key=have%2:39:06:: | definition=go through (mental or physical states or experiences) | synonyms=experience, receive, get | examples=get an idea; experience vertigo
4. sense_key=have%2:40:04:: | definition=have ownership or possession of | synonyms=own, possess | examples=He owns three houses in Florida; How many cars does she have?
5. sense_key=have%2:30:00:: | definition=cause to move; cause to be in a certain position or condition | synonyms=get, let | examples=He got his squad on the ball; This let me in for a big surprise
6. sense_key=have%2:34:00:: | definition=serve oneself to, or consume regularly | synonyms=consume, ingest, take in, take | examples=Have another bowl of chicken soup!; I don't take sugar in my coffee
7. sense_key=have%2:41:00:: | definition=have a personal or business relationship with someone | examples=have a postdoc; have an assistant
8. sense_key=have%2:36:00:: | definition=organize or be responsible for | synonyms=hold, throw, make, give | examples=hold a reception; have, throw, or make a party
9. sense_key=have%2:40:01:: | definition=have left | examples=I have two years left; I don't have any money left
10. sense_key=have%2:42:12:: | definition=be confronted with | examples=What do we have here?; Now we have a fine mess
11. sense_key=have%2:30:01:: | definition=undergo | synonyms=experience | examples=The stocks had a fast run-up
12. sense_key=have%2:29:02:: | definition=suffer from; be ill with | examples=She has arthritis
13. sense_key=have%2:32:00:: | definition=cause to do; cause to act in a specified manner | synonyms=induce, stimulate, cause, get, make | examples=The ads induced me to buy a VCR; My children finally got me to buy a computer
14. sense_key=have%2:40:05:: | definition=receive willingly something given or offered | synonyms=accept, take | examples=The only girl who would have him was the miller's daughter; I won't have this dog in my house!
15. sense_key=have%2:40:03:: | definition=get something; come into possession of | synonyms=receive | examples=receive payment; receive a gift
16. sense_key=have%2:29:05:: | definition=undergo (as of injuries and illnesses) | synonyms=suffer, sustain, get | examples=She suffered a fracture in the accident; He had an insulin shock after eating three candy bars
17. sense_key=have%2:40:02:: | definition=achieve a point or goal | synonyms=get, make | examples=Nicklaus had a 70; The Brazilian team got 4 goals
18. sense_key=have%2:29:00:: | definition=cause to be born | synonyms=give birth, deliver, bear, birth | examples=My wife had twins yesterday!
19. sense_key=have%2:35:00:: | definition=have sex with; archaic use | synonyms=take | examples=He had taken this woman when she was most vulnerable

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the context:** The sentence is: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects."
2.  **Identify the target word and its usage:** The target word is "have," used in the structure "who have certain other side effects."
3.  **Determine the meaning in context:** In this medical context, "having side effects" means experiencing or suffering from those effects.
4.  **Examine the candidate senses for relevance:**

    *   1. have or possess (concrete/abstract): Possible, but usually too general.
    *   2. have as a feature: Not relevant.
    *   3. go through (mental or physical states or experiences): Highly relevant. Side effects are experiences/states the patient goes through. Synonyms: experience, receive, get.
    *   4. have ownership or possession of: Not relevant.
    *   5. cause to move/be in a certain position: Not relevant.
    *   6. serve oneself to, or consume regularly: Not relevant (unless referring to consuming the side effect, which is unlikely).
    *   7. have a personal or business relationship with someone: Not relevant.
    *   8. organize or be responsible for: Not relevant.
    *   9. have left: Not relevant.
    *   10. be confronted with: Relevant, but perhaps less precise than 'experience' or 'suffer from'.
    *   11. undergo: Highly relevant. Synonyms: experience.
    *   12. suffer from; be ill with: Extremely relevant. This is the standard medical phrasing for having side effects.
    *   13. cause to do: Not relevant.
    *   14. receive willingly something given or offered: Not relevant.
    *   15. get something; come into possession of: Not relevant.
    *   16. undergo (as of injuries and illnesses): Extremely relevant. Synonyms: suffer, sustain, get.
    *   17. achieve a point or goal: Not relevant.
    *   18. cause to be born: Not relevant.
    *   19. have sex with: Not relevant.

5.  **Compare the best candidates (3, 11, 12, 16):**
    *   Sense 3 (go through/experience): Good fit.
    *   Sense 11 (undergo): Good fit.
    *   Sense 12 (suffer from; be ill with): Excellent fit. This directly addresses the concept of negative medical conditions (side effects).
    *   Sense 16 (undergo (as of injuries and illnesses)): Excellent fit. This is specific to physical ailments, which side effects are.

6.  **Select the single best fit:** While 3, 11, and 16 are strong, Sense 12 ("suffer from; be ill with") is the most idiomatic and precise way to describe the state of having negative medical symptoms (side effects) in a clinical context. Sense 16 is also very strong, but Sense 12 captures the meaning of *experiencing* the negative condition most directly.

7.  **Final check:** "who have certain other side effects" = "who suffer from certain other side effects." This matches Sense 12.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: certain
Target surface form: certain
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have <t>certain</t> other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=certain%5:00:00:definite:00 | definition=definite but not specified or identified | examples=set aside a certain sum each week; to a certain degree
2. sense_key=certain%3:00:02:: | definition=having or feeling no doubt or uncertainty; confident and assured | synonyms=sure | examples=felt certain of success; was sure (or certain) she had seen it
3. sense_key=certain%3:00:01:: | definition=established beyond doubt or question; definitely known | examples=what is certain is that every effect must have a cause; it is certain that they were on the bus
4. sense_key=certain%3:00:03:: | definition=certain to occur; destined or inevitable; ; ; - Benjamin Franklin | synonyms=sure | examples=he was certain to fail; his fate is certain
5. sense_key=certain%3:00:05:: | definition=established irrevocably | synonyms=sealed | examples=his fate is sealed
6. sense_key=certain%5:00:00:reliable:00 | definition=reliable in operation or effect | synonyms=sure | examples=a quick and certain remedy; a sure way to distinguish the two
7. sense_key=certain%5:00:00:careful:00 | definition=exercising or taking care great enough to bring assurance | synonyms=sure | examples=be certain to disconnect the iron when you are through; be sure to lock the doors

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "certain" in the provided context.

Context: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have <t>certain</t> other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems."

The phrase is "certain other side effects." This suggests a quantity or type of side effects that are not specified, but are present.

Let's analyze the candidate senses:

1. **sense_key=certain%5:00:00:definite:00 | definition=definite but not specified or identified | examples=set aside a certain sum each week; to a certain degree**
   * This sense relates to something being definite but unspecified (e.g., "a certain sum," "to a certain degree"). This fits the context of "certain other side effects," meaning some unspecified number or type of other side effects.

2. **sense_key=certain%3:00:02:: | definition=having or feeling no doubt or uncertainty; confident and assured | synonyms=sure | examples=felt certain of success; was sure (or certain) she had seen it**
   * This relates to certainty/confidence (e.g., "I am certain"). Does not fit "certain other side effects."

3. **sense_key=certain%3:00:01:: | definition=established beyond doubt or question; definitely known | examples=what is certain is that every effect must have a cause; it is certain that they were on the bus**
   * This relates to established facts (e.g., "It is certain that..."). Does not fit "certain other side effects."

4. **sense_key=certain%3:00:03:: | definition=certain to occur; destined or inevitable; ; ; - Benjamin Franklin | synonyms=sure | examples=he was certain to fail; his fate is certain**
   * This relates to inevitability (e.g., "It is certain to rain"). Does not fit "certain other side effects."

5. **sense_key=certain%3:00:05:: | definition=established irrevocably | synonyms=sealed | examples=his fate is sealed**
   * This relates to finality/irrevocability. Does not fit "certain other side effects."

6. **sense_key=certain%5:00:00:reliable:00 | definition=reliable in operation or effect | synonyms=sure | examples=a quick and certain remedy; a sure way to distinguish the two**
   * This relates to reliability (e.g., "a certain remedy"). Does not fit "certain other side effects."

7. **sense_key=certain%5:00:00:careful:00 | definition=exercising or taking care great enough to bring assurance | synonyms=sure | examples=be certain to disconnect the iron when you are through; be sure to lock the doors**
   * This relates to caution (e.g., "Be certain to..."). Does not fit "certain other side effects."

The phrase "certain other side effects" functions as a quantifier or an indefinite descriptor, meaning "some other side effects" or "a certain number of other side effects."

Sense 1: "definite but not specified or identified" aligns perfectly with this usage (e.g., "a certain amount," "a certain number").

Therefore, sense 1 is the best fit.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: other
Target surface form: other
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain <t>other</t> side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=other%3:00:00:: | definition=not the same one or ones already mentioned or implied; - the White Queen | examples=today isn't any other day; the construction of highways and other public works
2. sense_key=other%5:00:00:past:00 | definition=recently past | examples=the other evening
3. sense_key=other%5:00:02:past:00 | definition=belonging to the distant past | synonyms=early, former | examples=the early inhabitants of Europe; former generations
4. sense_key=other%5:00:00:strange:00 | definition=very unusual; different in character or quality from the normal or expected; - Lance Morrow | examples=a strange, other dimension...where his powers seemed to fail

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "other" in the given context.

Context: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain <t>other</t> side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems."

Target word: "other"

Candidate senses:
1. sense_key=other%3:00:00:: | definition=not the same one or ones already mentioned or implied; - the White Queen | examples=today isn't any other day; the construction of highways and other public works
2. sense_key=other%5:00:02:past:00 | definition=belonging to the distant past | synonyms=early, former | examples=the early inhabitants of Europe; former generations
3. sense_key=other%5:00:00:strange:00 | definition=very unusual; different in character or quality from the normal or expected; - Lance Morrow | examples=a strange, other dimension...where his powers seemed to fail
4. sense_key=other%5:00:00:past:00 | definition=recently past | examples=the other evening

Analysis of the context:
The sentence reads: "...or who have certain other side effects."
"Side effects" are adverse reactions to the drug Alimta.
The phrase "certain other side effects" implies side effects that are not the ones already known, mentioned, or expected/implied in the context of the treatment (or perhaps side effects that are not the primary ones being discussed).

Evaluation of candidate senses:

1. sense_key=other%3:00:00:: | definition=not the same one or ones already mentioned or implied;
This sense perfectly matches the usage. "Other" here means additional, different from those already known or discussed.

2. sense_key=other%5:00:02:past:00 | definition=belonging to the distant past
Irrelevant. The context is about current medical conditions/side effects.

3. sense_key=other%5:00:00:strange:00 | definition=very unusual; different in character or quality from the normal or expected;
While "other" can sometimes imply unusualness, the primary function here is to indicate *additional* or *unspecified* types of side effects, not necessarily that they are bizarre or strange (though they might be). Sense 1 is a much more precise fit for the grammatical and semantic role of "other" in this construction ("certain other X").

4. sense_key=other%5:00:00:past:00 | definition=recently past
Irrelevant.

Conclusion: Sense 1, defined as "not the same one or ones already mentioned or implied," is the best fit for "certain other side effects."


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: side_effect
Target surface form: side effects
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other <t>side effects</t>. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=side_effect%1:26:00:: | definition=a secondary and usually adverse effect of a drug or therapy | examples=severe headaches are one of the side effects of the drug
2. sense_key=side_effect%1:19:00:: | definition=any adverse and unwanted secondary effect | synonyms=fallout | examples=a strategy to contain the fallout from the accounting scandal

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{
  "sense_index": 1
}
```

reasoning_content:
Thinking Process:

1.  **Analyze the Target and Context:**
    *   Target lemma: `side_effect`
    *   Target surface form: `side effects`
    *   Context snippet: "...or who have certain other <t>side effects</t>." (The context is discussing chemotherapy treatment (Alimta, cisplatin), dosage, and managing adverse reactions like vomiting and dehydration.)

2.  **Analyze the Candidate Senses:**

    *   **Sense 1:**
        *   `sense_key=side_effect%1:26:00`
        *   Definition: "a secondary and usually adverse effect of a drug or therapy"
        *   Examples: "severe headaches are one of the side effects of the drug"
        *   *Relevance Check:* The context is explicitly about drug therapy (Alimta, cisplatin) and managing adverse outcomes. This definition fits perfectly.

    *   **Sense 2:**
        *   `sense_key=side_effect%1:19:00`
        *   Definition: "any adverse and unwanted secondary effect"
        *   Synonyms: "fallout"
        *   Examples: "a strategy to contain the fallout from the accounting scandal"
        *   *Relevance Check:* The inclusion of "fallout" and the example about an "accounting scandal" strongly suggest a metaphorical or political/consequential meaning (e.g., negative consequences of an event), not a biological/medical reaction to a drug.

3.  **Compare and Select:**
    *   The context is purely medical/pharmacological.
    *   Sense 1 defines `side effects` specifically in the context of drugs/therapy and adverse outcomes (e.g., headaches from a drug).
    *   Sense 2 is general and heavily skewed towards metaphorical consequences (fallout).
    *   Sense 1 is the clear and precise match for the usage in the provided text.

4.  **Final Output Generation:** (Must be a JSON object with the sense index.)
    *   Sense 1 corresponds to index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: use
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for <t>use</t> in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=use%1:04:00:: | definition=the act of using | synonyms=usage, utilization, utilisation, employment, exercise | examples=he warned against the use of narcotic drugs; skilled in the utilization of computers
2. sense_key=use%1:07:00:: | definition=what something is used for | synonyms=function, purpose, role | examples=the function of an auger is to bore holes; ballet is beautiful but what use is it?
3. sense_key=use%1:07:02:: | definition=a particular service | examples=he put his knowledge to good use; patrons have their uses
4. sense_key=use%1:22:00:: | definition=(economics) the utilization of economic goods to satisfy needs or in manufacturing | synonyms=consumption, economic consumption, usance, use of goods and services | examples=the consumption of energy has increased steadily
5. sense_key=use%1:04:01:: | definition=(psychology) an automatic pattern of behavior in reaction to a specific situation; may be inherited or acquired through frequent repetition | synonyms=habit | examples=owls have nocturnal habits; she had a habit twirling the ends of her hair
6. sense_key=use%1:04:02:: | definition=exerting shrewd or devious influence especially for one's own advantage | synonyms=manipulation | examples=his manipulation of his friends was scandalous
7. sense_key=use%1:07:03:: | definition=(law) the exercise of the legal right to enjoy the benefits of owning property | synonyms=enjoyment | examples=we were given the use of his boat

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "use" in the given context.
The context is: "Alimta is not recommended for <t>use</t> in patients with moderate or severe kidney problems."

The target word "use" here refers to the application or administration of the drug Alimta in patients with kidney problems.

Let's analyze the candidate senses:

1. **sense_key=use%1:04:00:: | definition=the act of using | synonyms=usage, utilization, utilisation, employment, exercise | examples=he warned against the use of narcotic drugs; skilled in the utilization of computers**
   * This sense relates to the act of utilizing something (the drug). This fits well with "not recommended for use."

2. **sense_key=use%1:07:00:: | definition=what something is used for | synonyms=function, purpose, role | examples=the function of an auger is to bore holes; ballet is beautiful but what use is it?**
   * This refers to purpose/function. While related, the context is about whether the drug *should* be administered, not what its purpose is.

3. **sense_key=use%1:07:02:: | definition=a particular service | examples=he put his knowledge to good use; patrons have their uses**
   * This sense is about a service or benefit derived from something. "Not recommended for use" doesn't strongly align with "a particular service."

4. **sense_key=use%1:22:00:: | definition=(economics) the utilization of economic goods to satisfy needs or in manufacturing | synonyms=consumption, economic consumption, usance, use of goods and services | examples=the consumption of energy has increased steadily**
   * This is specifically economic utilization. While drugs are goods, the context is medical recommendation, not economic consumption patterns.

5. **sense_key=use%1:04:01:: | definition=(psychology) an automatic pattern of behavior in reaction to a specific situation; may be inherited or acquired through frequent repetition | synonyms=habit | examples=owls have nocturnal habits; she had a habit twirling the ends of her hair**
   * This is "habit." Irrelevant.

6. **sense_key=use%1:04:02:: | definition=exerting shrewd or devious influence especially for one's own advantage | synonyms=manipulation | examples=his manipulation of his friends was scandalous**
   * This is manipulation. Irrelevant.

7. **sense_key=use%1:07:03:: | definition=(law) the exercise of the legal right to enjoy the benefits of owning property | synonyms=enjoyment | examples=we were given the use of his boat**
   * This is legal usage/enjoyment. Irrelevant.

Comparing Sense 1 and Sense 3:
Sense 1: "the act of using" (usage, utilization). This perfectly captures the meaning of "not recommended for [the act of] using Alimta."
Sense 3: "a particular service." This is too narrow and doesn't fit the medical context of administration/application.

Sense 1 is the best fit.

The required output format is a JSON object with the sense index.
Sense 1 corresponds to index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in <t>patients</t> with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{
  "sense_index": 1
}
```

reasoning_content:
The user wants me to perform Word Sense Disambiguation (WSD) for the target word "patients" (plural of "patient") based on the provided context.

Context analysis:
The text discusses a drug (Alimta) treatment regimen. It mentions:
1. Dosage calculation based on patient's height and weight.
2. Treatment procedures (intravenous infusion, injections).
3. Side effects and necessary supplements (corticosteroid, folic acid, B12).
4. Treatment adjustments based on patient's blood counts or side effects.
5. Contraindications: "Alimta is not recommended for use in <t>patients</t> with moderate or severe kidney problems."

The word "patients" refers to individuals receiving medical treatment.

Candidate senses:
1. `sense_key=patient%1:18:00`: definition=a person who requires medical care. Example: the number of emergency patients has grown rapidly.
2. `sense_key=patient%1:10:00`: definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause. Synonyms=affected role, patient role.

Evaluation:
Sense 1 clearly defines "patient" as a person needing medical care. This aligns perfectly with the context (receiving Alimta treatment, having kidney problems, etc.).
Sense 2 defines "patient" as a grammatical/semantic role (the patient role in linguistics/semantics). This is an abstract concept and does not fit the usage in the sentence ("Alimta is not recommended for use in patients...").

Conclusion: Sense 1 is the correct interpretation.

The required output format is a JSON object with the sense index. Since the candidates are numbered 1 and 2, I must choose the index corresponding to Sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: moderate
Target surface form: moderate
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with <t>moderate</t> or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=moderate%3:00:00:: | definition=being within reasonable or average limits; not excessive or extreme | examples=moderate prices; a moderate income
2. sense_key=moderate%5:00:00:mild:00 | definition=not extreme | synonyms=temperate | examples=a moderate penalty; temperate in his response to criticism
3. sense_key=moderate%5:00:00:temperate:00 | definition=marked by avoidance of extravagance or extremes | synonyms=restrained | examples=moderate in his demands; restrained in his response

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "moderate" in the given context.

Context: "Alimta is not recommended for use in patients with <t>moderate</t> or severe kidney problems."

Target word: moderate (adjective, modifying "kidney problems").

Candidate senses:
1. sense_key=moderate%3:00:00:: | definition=being within reasonable or average limits; not excessive or extreme | examples=moderate prices; a moderate income
2. sense_key=moderate%5:00:00:mild:00 | definition=not extreme | synonyms=temperate | examples=a moderate penalty; temperate in his response to criticism
3. sense_key=moderate%5:00:00:temperate:00 | definition=marked by avoidance of extravagance or extremes | synonyms=restrained | examples=moderate in his demands; restrained in his response

Analysis:
The context discusses kidney problems. The phrase is "moderate or severe kidney problems." This implies a scale of severity. "Moderate" here means of an intermediate level, not mild, but also not severe.

Let's evaluate the senses:

1. **sense_key=moderate%3:00:00::** Definition: "being within reasonable or average limits; not excessive or extreme." This fits the idea of a level of severity that is neither mild nor severe, but average or within a defined range.
2. **sense_key=moderate%5:00:00:mild:00** Definition: "not extreme." This is a general definition of low intensity. While applicable, it is less specific than sense 1 regarding a measurable level.
3. **sense_key=moderate%5:00:00:temperate:00** Definition: "marked by avoidance of extravagance or extremes." This sense usually relates to behavior, temperament, or style (e.g., a temperate climate, a temperate person). It is less suitable for describing the *degree* of a medical condition like kidney problems.

Comparing 1 and 2:
Sense 1 ("being within reasonable or average limits; not excessive or extreme") is the most precise fit for describing the degree of a medical condition (kidney problems) when contrasted with "severe." It implies a measurable, intermediate level.

Therefore, sense 1 is the best choice.

Wait, the instructions require me to return the JSON object with the *sense_index*. I need to map the chosen sense (Sense 1) to its index.

Sense 1 -> index 1.
Sense 2 -> index 2.
Sense 3 -> index 3.

The best sense is Sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: severe
Target surface form: severe
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or <t>severe</t> kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=severe%5:00:00:intense:00 | definition=intensely or extremely bad or unpleasant in degree or quality | synonyms=terrible, wicked | examples=severe pain; a severe case of flu
2. sense_key=severe%5:00:00:strong:00 | definition=very strong or vigorous | synonyms=hard, knockout | examples=strong winds; a hard left to the chin
3. sense_key=severe%5:00:00:plain:01 | definition=severely simple | synonyms=austere, stark, stern | examples=a stark interior
4. sense_key=severe%5:00:02:nonindulgent:00 | definition=unsparing and uncompromising in discipline or judgment; - H.G.Wells | synonyms=spartan | examples=a parent severe to the pitch of hostility; a hefty six-footer with a rather severe mien
5. sense_key=severe%5:00:00:critical:03 | definition=causing fear or anxiety by threatening great harm | synonyms=dangerous, grave, grievous, serious, life-threatening | examples=a dangerous operation; a grave situation
6. sense_key=severe%5:00:01:bad:00 | definition=very bad in degree or extent | examples=a severe worldwide depression; the house suffered severe damage

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "severe" in the given context.

Context: "Alimta is not recommended for use in patients with moderate or <t>severe</t> kidney problems."

Target word: severe
Candidate senses:
1. sense_key=severe%5:00:00:intense:00 | definition=intensely or extremely bad or unpleasant in degree or quality | synonyms=terrible, wicked | examples=severe pain; a severe case of flu
2. sense_key=severe%5:00:00:strong:00 | definition=very strong or vigorous | synonyms=hard, knockout | examples=strong winds; a hard left to the chin
3. sense_key=severe%5:00:01:bad:00 | definition=very bad in degree or extent | examples=a severe worldwide depression; the house suffered severe damage
4. sense_key=severe%5:00:02:nonindulgent:00 | definition=unsparing and uncompromising in discipline or judgment; - H.G.Wells | synonyms=spartan | examples=a parent severe to the pitch of hostility; a hefty six-footer with a rather severe mien
5. sense_key=severe%5:00:00:critical:03 | definition=causing fear or anxiety by threatening great harm | synonyms=dangerous, grave, grievous, serious, life-threatening | examples=a dangerous operation; a grave situation
6. sense_key=severe%5:00:00:intense:00 | definition=intensely or extremely bad or unpleasant in degree or quality | synonyms=terrible, wicked | examples=severe pain; a severe case of flu (Wait, sense 1 and sense 6 seem identical in the provided list, but I must treat them as distinct if they are indexed differently. Let's check the provided list again. Sense 1 and Sense 6 are identical in definition and synonyms, but I will evaluate based on the meaning.)

The context relates "severe" to "kidney problems" and is used in a medical/clinical setting to describe the degree of the condition.

Let's evaluate the candidates:

1. **intense/extremely bad in degree or quality:** Fits well with describing a medical condition (kidney problems).
2. **very strong or vigorous:** Does not fit the context of a disease state.
3. **very bad in degree or extent:** Fits well with describing the severity of a medical condition.
4. **unsparing and uncompromising (discipline):** Irrelevant to kidney problems.
5. **causing fear or anxiety by threatening great harm (critical):** This sense often overlaps with "serious" or "grave," which is highly relevant to medical conditions.
6. **intensely or extremely bad in degree or quality:** Same as 1.

Comparing 1, 3, and 5:

*   **Sense 1/6 (intense/extremely bad):** General description of high degree/quality.
*   **Sense 3 (very bad in degree or extent):** Focuses specifically on the extent/degree of something negative.
*   **Sense 5 (critical/threatening great harm):** Focuses on the potential danger or seriousness of the condition.

In medical terminology, when describing the degree of a disease (like kidney problems), terms like "severe," "moderate," "mild," etc., usually refer to the *extent* or *intensity* of the impairment.

Sense 3 ("very bad in degree or extent") is a very direct match for describing the level of kidney problems.
Sense 5 ("causing fear or anxiety by threatening great harm") is also plausible, as severe kidney problems are dangerous, but Sense 3 captures the quantitative/qualitative description of the *problem itself* better than the *consequence* (threat of harm).

Let's look at the synonyms for Sense 5: dangerous, grave, grievous, serious, life-threatening. "Serious" is a very common descriptor for medical conditions.
Let's look at the synonyms for Sense 3: (None listed, but the definition is clear: very bad in degree or extent).

Given the pairing with "moderate," the word "severe" is functioning as a graded adjective describing the level of the kidney problem. Both Sense 3 and Sense 5 are strong contenders.

However, Sense 3, "very bad in degree or extent," is the most precise fit for describing the *level* of a physical condition (kidney problems) when contrasted with "moderate."

I will choose Sense 3.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: problem
Target surface form: problems
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney <t>problems</t>. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=problem%1:26:00:: | definition=a state of difficulty that needs to be resolved | synonyms=job | examples=she and her husband are having problems; it is always a job to contact him
2. sense_key=problem%1:10:00:: | definition=a question raised for consideration or solution | examples=our homework consisted of ten problems to solve
3. sense_key=problem%1:09:00:: | definition=a source of difficulty | synonyms=trouble | examples=one trouble after another delayed the job; what's the problem?

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation (WSD) for the word "problems" in the given context.
The target lemma is "problem".
The target surface form is "problems".
The context is: "Alimta is not recommended for use in patients with moderate or severe kidney <t>problems</t>."

I need to evaluate the three candidate senses:

1. **sense_key=problem%1:26:00:** definition=a state of difficulty that needs to be resolved; synonyms=job. (Focuses on a state of difficulty/issue).
2. **sense_key=problem%1:10:00:** definition=a question raised for consideration or solution; examples=our homework consisted of ten problems to solve. (Focuses on academic/logical questions).
3. **sense_key=problem%1:09:00:** definition=a source of difficulty; synonyms=trouble; examples=one trouble after another delayed the job; what's the problem? (Focuses on a source or instance of difficulty/trouble).

**Analysis of the context:**
"Alimta is not recommended for use in patients with moderate or severe kidney problems."
Here, "kidney problems" refers to issues or difficulties related to the kidneys, specifically conditions that affect kidney function (e.g., kidney disease, kidney failure).

**Evaluation of senses:**

*   **Sense 2 (Question/Solution):** This is clearly incorrect. The context is medical, not academic.
*   **Sense 1 (State of difficulty):** "A state of difficulty that needs to be resolved." This fits well. Kidney problems are states of difficulty in kidney function.
*   **Sense 3 (Source of difficulty/Trouble):** "A source of difficulty." This also fits very well. Kidney problems are sources of difficulty for the patient.

**Distinguishing between Sense 1 and Sense 3:**
Sense 1: "a state of difficulty that needs to be resolved"
Sense 3: "a source of difficulty"

In medical terminology, "kidney problems" usually refers to the underlying condition or set of symptoms/dysfunctions (the source/state of difficulty). Both definitions are very close.

Let's look at the synonyms provided:
Sense 1 synonyms: job (less relevant here)
Sense 3 synonyms: trouble (highly relevant here)

The phrase "kidney problems" is a common collocation for medical conditions or issues. Sense 3, defined as "a source of difficulty" and associated with "trouble," captures the nature of a medical ailment better than Sense 1, which emphasizes the *need* for resolution (though that is implied).

Given the strong synonym match ("trouble") and the general usage in medical contexts (where a condition *is* the source of difficulty), Sense 3 seems the most precise fit for describing a pathological state like kidney dysfunction.

Therefore, Sense 3 is the best choice.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: more
Target surface form: more
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For <t>more</t> information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=more%3:00:01:: | definition=(comparative of `much' used with mass nouns) a quantifier meaning greater in size or amount or extent or degree | synonyms=more than | examples=more land; more support
2. sense_key=more%3:00:02:: | definition=(comparative of `many' used with count nouns) quantifier meaning greater in number | examples=a hall with more seats; we have no more bananas

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{
  "sense_index": 1
}
```

reasoning_content:
1.  **Analyze the target word and context:**
    *   Target word: "more"
    *   Context sentence: "For <t>more</t> information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?"
    *   The phrase is "For more information".

2.  **Analyze the candidate senses:**
    *   Sense 1: `more%3:00:01` | definition=(comparative of `much' used with mass nouns) a quantifier meaning greater in size or amount or extent or degree | synonyms=more than | examples=more land; more support. (Focuses on quantity/amount, often abstract or uncountable.)
    *   Sense 2: `more%3:00:02` | definition=(comparative of `many' used with count nouns) quantifier meaning greater in number | examples=a hall with more seats; we have no more bananas. (Focuses on number/count.)

3.  **Determine the usage in context:**
    *   "Information" is an uncountable (mass) noun.
    *   The phrase "more information" means a greater amount or extent of information.
    *   This usage aligns with the function of "more" as a comparative quantifier for mass nouns.

4.  **Match context usage to senses:**
    *   Sense 1 deals with mass nouns and extent/amount (e.g., more land, more support, more information). This is a strong match.
    *   Sense 2 deals with count nouns (e.g., more seats, more bananas). This is incorrect.

5.  **Select the best sense:** Sense 1 is the best fit.

6.  **Format the output:** The instruction requires returning a JSON object with the sense index. Since the provided candidates are numbered 1 and 2, and Sense 1 is the correct choice, the index is 1. (Wait, the prompt structure implies the final output should be based on the provided list, and the instruction says "Return only a JSON object exactly like {"sense_index": 3}". I must ensure I use the correct index from the provided list, which is 1.)

*Self-Correction/Review:* The provided candidates are indexed 1 and 2. I chose Sense 1. I must output `{"sense_index": 1}`.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: information
Target surface form: information
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more <t>information</t>, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=information%1:10:00:: | definition=a message received and understood | synonyms=info
2. sense_key=information%1:09:00:: | definition=knowledge acquired through study or experience or instruction
3. sense_key=information%1:10:02:: | definition=formal accusation of a crime
4. sense_key=information%1:14:00:: | definition=a collection of facts from which conclusions may be drawn | synonyms=data | examples=statistical data
5. sense_key=information%1:07:00:: | definition=(communication theory) a numerical measure of the uncertainty of an outcome | synonyms=selective information, entropy | examples=the signal contained thousands of bits of information

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "information" in the given context.

Context: "For more <t>information</t>, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?"

Candidate Senses:
1. sense_key=information%1:10:00:: | definition=a message received and understood | synonyms=info
2. sense_key=information%1:09:00:: | definition=knowledge acquired through study or experience or instruction
3. sense_key=information%1:10:02:: | definition=formal accusation of a crime
4. sense_key=information%1:14:00:: | definition=a collection of facts from which conclusions may be drawn | synonyms=data | examples=statistical data
5. sense_key=information%1:07:00:: | definition=(communication theory) a numerical measure of the uncertainty of an outcome | synonyms=selective information, entropy | examples=the signal contained thousands of bits of information

Analysis:
The phrase is "For more information, see the Summary of Product Characteristics (also part of the EPAR)."
The context is medical/pharmaceutical (Alimta, cisplatin, EPAR, Summary of Product Characteristics).
When a document refers the reader to a source for "more information," it means they want more details, knowledge, or facts about the topic (Alimta/treatment).

Let's evaluate the senses:
1. "a message received and understood": Plausible, but perhaps too narrow.
2. "knowledge acquired through study or experience or instruction": This fits perfectly. The Summary of Product Characteristics is a document providing detailed knowledge about the drug.
3. "formal accusation of a crime": Irrelevant.
4. "a collection of facts from which conclusions may be drawn": Plausible, as the document contains facts/data, but "knowledge" (Sense 2) is a better fit for the general request for "more information" in this context.
5. "a numerical measure of the uncertainty of an outcome": Irrelevant (technical/communication theory).

Comparing Sense 1 and Sense 2:
Sense 1 (a message received and understood) is a component of knowledge.
Sense 2 (knowledge acquired through study or experience or instruction) captures the comprehensive nature of the information provided in a formal document like the Summary of Product Characteristics.

Sense 2 is the most appropriate interpretation for a request to read a detailed document for "more information."

Conclusion: Sense 2 is the best fit.