[User]
Which numbered sense of "certain" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have <t>certain</t> other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Senses:
1. definition=definite but not specified or identified | examples=set aside a certain sum each week; to a certain degree
2. definition=having or feeling no doubt or uncertainty; confident and assured | synonyms=sure | examples=felt certain of success; was sure (or certain) she had seen it
3. definition=established beyond doubt or question; definitely known | examples=what is certain is that every effect must have a cause; it is certain that they were on the bus
4. definition=certain to occur; destined or inevitable; ; ; - Benjamin Franklin | synonyms=sure | examples=he was certain to fail; his fate is certain
5. definition=established irrevocably | synonyms=sealed | examples=his fate is sealed
6. definition=reliable in operation or effect | synonyms=sure | examples=a quick and certain remedy; a sure way to distinguish the two
7. definition=exercising or taking care great enough to bring assurance | synonyms=sure | examples=be certain to disconnect the iron when you are through; be sure to lock the doors

reasoning_content:
1.  **Analyze the Request:** The goal is to identify which numbered sense of "certain" (marked with <t>certain</t>) is used in the provided context.

2.  **Examine the Context:**
    "Alimta is not recommended for use in patients with moderate or severe kidney problems. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have <t>certain</t> other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems."

3.  **Analyze the Target Word Usage:** The phrase is "who have certain other side effects." This implies that the side effects are known, established, or definitely present, leading to a recommendation (delay/discontinue/reduce).

4.  **Evaluate the Senses:**

    *   **Sense 1:** definition=definite but not specified or identified | examples=set aside a certain sum each week; to a certain degree. (Doesn't fit the context of established medical facts/side effects.)
    *   **Sense 2:** definition=having or feeling no doubt or uncertainty; confident and assured | synonyms=sure | examples=felt certain of success; was sure (or certain) she had seen it. (Focuses on personal confidence/lack of doubt. Possible, but usually less formal/definitive than other senses.)
    *   **Sense 3:** definition=established beyond doubt or question; definitely known | examples=what is certain is that every effect must have a cause; it is certain that they were on the bus. (Focuses on established knowledge/fact. This fits the idea that these side effects are known/established.)
    *   **Sense 4:** definition=certain to occur; destined or inevitable; ; ; - Benjamin Franklin | synonyms=sure | examples=he was certain to fail; his fate is certain. (Focuses on inevitability/destiny. Doesn't fit the context of patient symptoms.)
    *   **Sense 5:** definition=established irrevocably | synonyms=sealed | examples=his fate is sealed. (Focuses on finality/irrevocability. Too strong for describing a list of side effects.)
    *   **Sense 6:** definition=reliable in operation or effect | synonyms=sure | examples=a quick and certain remedy; a sure way to distinguish the two. (Focuses on reliability/dependability. Doesn't fit.)
    *   **Sense 7:** definition=exercising or taking care great enough to bring assurance | synonyms=sure | examples=be certain to disconnect the iron when you are through; be sure to lock the doors. (Focuses on taking care/assurance. Doesn't fit.)

5.  **Conclusion:** The context uses "certain" to describe side effects that are known or established facts that warrant caution. Sense 3 ("established beyond doubt or question; definitely known") is the best fit.


attempt_kind: initial

status: success

[User]
Which numbered sense of "other" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain <t>other</t> side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Senses:
1. definition=not the same one or ones already mentioned or implied; - the White Queen | examples=today isn't any other day; the construction of highways and other public works
2. definition=recently past | examples=the other evening
3. definition=belonging to the distant past | synonyms=early, former | examples=the early inhabitants of Europe; former generations
4. definition=very unusual; different in character or quality from the normal or expected; - Lance Morrow | examples=a strange, other dimension...where his powers seemed to fail

finish_reason: stop

role: assistant

reasoning_content:
1.  **Analyze the Request:** The goal is to identify which numbered sense of "other" (marked with <t>other</t>) is used in the provided context.

2.  **Examine the Context:**
    "Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain <t>other</t> side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems."

3.  **Locate the Target Word:** The target is "<t>other</t>".

4.  **Analyze the Usage in Context:** "...patients whose blood counts are abnormal or who have certain other side effects."
    In this context, "other side effects" means side effects that are not the previously mentioned or implied side effects (e.g., vomiting, dehydration, or specific known side effects). It implies something different, unusual, or not specifically listed.

5.  **Evaluate the Senses:**

    *   **Sense 1:** definition=not the same one or ones already mentioned or implied; - the White Queen | examples=today isn't any other day; the construction of highways and other public works
        *   *Match Check:* This definition perfectly aligns with "other side effects" (side effects that are not the ones already mentioned).

    *   **Sense 2:** definition=recently past | examples=the other evening
        *   *Match Check:* No.

    *   **Sense 3:** definition=belonging to the distant past | synonyms=early, former | examples=the early inhabitants of Europe; former generations
        *   *Match Check:* No.

    *   **Sense 4:** definition=very unusual; different in character or quality from the normal or expected; - Lance Morrow | examples=a strange, other dimension...where his powers seemed to fail
        *   *Match Check:* While "other" can mean unusual, the context here is clinical/medical (side effects), referring to things *not mentioned*, rather than things that are inherently strange or dimensionally different. Sense 1 is a much closer fit for distinguishing items from a set.

6.  **Conclusion:** Sense 1 is the correct meaning.

currency: USD

source: unavailable


[User]
Which numbered sense of "side_effect" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other <t>side effects</t>. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Senses:
1. definition=a secondary and usually adverse effect of a drug or therapy | examples=severe headaches are one of the side effects of the drug
2. definition=any adverse and unwanted secondary effect | synonyms=fallout | examples=a strategy to contain the fallout from the accounting scandal

reasoning_content:
1.  **Analyze the Request:** The user wants to identify which numbered sense of "side_effect" (marked with `<t></t>`) is used in the provided context.

2.  **Analyze the Context:**
    "Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other <t>side effects</t>. Alimta is not recommended for use in patients with moderate or severe kidney problems."

3.  **Analyze the Target Phrase:** The phrase is "<t>side effects</t>".

4.  **Analyze the Senses:**
    *   Sense 1: definition=a secondary and usually adverse effect of a drug or therapy | examples=severe headaches are one of the side effects of the drug
    *   Sense 2: definition=any adverse and unwanted secondary effect | synonyms=fallout | examples=a strategy to contain the fallout from the accounting scandal

5.  **Compare Context Usage with Senses:**
    *   The context discusses conditions (abnormal blood counts, certain other side effects) that necessitate delaying or stopping treatment.
    *   Sense 1 focuses on "secondary and usually adverse effect of a drug or therapy."
    *   Sense 2 focuses on "any adverse and unwanted secondary effect."

6.  **Determine the Best Fit:** Both senses describe adverse effects.
    *   Sense 1 is very specific: "secondary and usually adverse effect of a drug or therapy."
    *   Sense 2 is broader: "any adverse and unwanted secondary effect."

    In medical contexts, "side effect" often refers to the adverse effects resulting from a drug. Sense 1 captures the core meaning of a drug's effect (secondary/adverse effect of a drug/therapy). Sense 2 is also accurate but slightly more general (using "any adverse and unwanted").

    Let's re-read the definitions and examples.
    Sense 1: "a secondary and usually adverse effect of a drug or therapy" (Matches the context perfectly, as the context is about drug treatment).
    Sense 2: "any adverse and unwanted secondary effect" (Also fits, but Sense 1 is a more precise definition of what a drug side effect is).

    Since the context is explicitly about the effects of Alimta (a drug), Sense 1 is the most precise and appropriate definition.

7.  **Final Check:** The context uses "certain other side effects" in the context of drug treatment consequences. Sense 1 defines this as a "secondary and usually adverse effect of a drug or therapy." This is the correct sense.

8.  **Return the Number:** 1.


[User]
Which numbered sense of "use" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for <t>use</t> in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Senses:
1. definition=the act of using | synonyms=usage, utilization, utilisation, employment, exercise | examples=he warned against the use of narcotic drugs; skilled in the utilization of computers
2. definition=what something is used for | synonyms=function, purpose, role | examples=the function of an auger is to bore holes; ballet is beautiful but what use is it?
3. definition=a particular service | examples=he put his knowledge to good use; patrons have their uses
4. definition=(economics) the utilization of economic goods to satisfy needs or in manufacturing | synonyms=consumption, economic consumption, usance, use of goods and services | examples=the consumption of energy has increased steadily
5. definition=(psychology) an automatic pattern of behavior in reaction to a specific situation; may be inherited or acquired through frequent repetition | synonyms=habit | examples=owls have nocturnal habits; she had a habit twirling the ends of her hair
6. definition=exerting shrewd or devious influence especially for one's own advantage | synonyms=manipulation | examples=his manipulation of his friends was scandalous
7. definition=(law) the exercise of the legal right to enjoy the benefits of owning property | synonyms=enjoyment | examples=we were given the use of his boat

reasoning_content:
1.  **Analyze the Request:** The user wants to identify the correct numbered sense of the word "use" (marked with <t>use</t>) in the provided context and return only the number.

2.  **Examine the Context:** "Alimta is not recommended for <t>use</t> in patients with moderate or severe kidney problems."

3.  **Determine the Meaning of "use" in Context:** The sentence implies that Alimta should not be employed, applied, or utilized in patients with kidney problems. This points towards the concept of function, purpose, or application.

4.  **Evaluate the Senses:**

    *   **Sense 1:** definition=the act of using | synonyms=usage, utilization, utilisation, employment, exercise. (Example: warned against the use of narcotic drugs; skilled in the utilization of computers). *This focuses on the action/act of using.*
    *   **Sense 2:** definition=what something is used for | synonyms=function, purpose, role. (Example: the function of an auger is to bore holes; ballet is beautiful but what use is it?). *This focuses on the purpose or function.*
    *   **Sense 3:** definition=a particular service. (Example: he put his knowledge to good use; patrons have their uses). *This focuses on a service or benefit.*
    *   **Sense 4:** definition=(economics) the utilization of economic goods to satisfy needs or in manufacturing. (Example: the consumption of energy has increased steadily). *This is an economic definition.*
    *   **Sense 5:** definition=(psychology) an automatic pattern of behavior...; may be inherited or acquired through frequent repetition. (Example: owls have nocturnal habits). *This is a psychological definition (habit).*
    *   **Sense 6:** definition=exerting shrewd or devious influence... (Example: his manipulation of his friends was scandalous). *This is manipulation.*
    *   **Sense 7:** definition=(law) the exercise of the legal right to enjoy the benefits of owning property. (Example: we were given the use of his boat). *This is legal enjoyment.*

5.  **Match Context to Senses:**
    *   The context is about recommending a drug based on a condition (kidney problems). It is asking if the drug is appropriate for that *function* or *application*.
    *   Sense 2: "what something is used for" (function, purpose) fits perfectly: "Alimta is not recommended for [its function/purpose] in patients with moderate or severe kidney problems."
    *   Sense 1: "the act of using" is too broad; Sense 2 is more specific to the *reason* for the restriction.

6.  **Conclusion:** Sense 2 is the most appropriate meaning.


[User]
Which numbered sense of "patient" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in <t>patients</t> with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Senses:
1. definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

reasoning_content:
1.  **Analyze the Request:** The user wants to identify which numbered sense of the word "patient" (<t>patients</t>) is used in the provided context. The answer should be only the number.

2.  **Analyze the Context:**
    "The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR)."

3.  **Analyze the Target Word/Phrase:** The word is "patients" (and "patient" singular).

4.  **Analyze the Senses Provided:**
    *   Sense 1: definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
    *   Sense 2: definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

5.  **Apply Senses to the Context:**

    *   *Context Snippet 1:* "(calculated using the patient s height and weight)." -> Here, "patient" refers to the individual receiving the calculation/dose. This aligns with "a person who requires medical care."
    *   *Context Snippet 2:* "To reduce side effects, patients should take a corticosteroid..." -> Here, "patients" are the individuals receiving the treatment and experiencing side effects. This aligns with "a person who requires medical care."
    *   *Context Snippet 3:* "...in patients whose blood counts are abnormal or who have certain other side effects." -> Here, "patients" are the individuals who are affected by the treatment/condition. This aligns with "the semantic role of an entity that is not the agent but is directly involved in or affected by the happening."

6.  **Determine the Primary/Dominant Sense:** The context uses "patients" primarily to refer to individuals who are receiving medical treatment or are affected by a medical condition (kidney problems, abnormal blood counts, side effects).

    *   Sense 1 (a person who requires medical care) is the core definition.
    *   Sense 2 (affected role) is also relevant, but Sense 1 is the fundamental definition being applied throughout the text (e.g., calculating dose *for* the patient, patients *taking* medication).

7.  **Conclusion:** The context overwhelmingly uses "patient" in the sense of a person requiring medical care.

8.  **Final Check against Options:**
    *   Sense 1: definition=a person who requires medical care. (Matches the usage.)
    *   Sense 2: definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening. (Matches a secondary usage, but Sense 1 is the primary meaning.)

9.  **Return the Number:** 1.


[User]
Which numbered sense of "moderate" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with <t>moderate</t> or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Senses:
1. definition=being within reasonable or average limits; not excessive or extreme | examples=moderate prices; a moderate income
2. definition=not extreme | synonyms=temperate | examples=a moderate penalty; temperate in his response to criticism
3. definition=marked by avoidance of extravagance or extremes | synonyms=restrained | examples=moderate in his demands; restrained in his response

reasoning_content:
1.  **Analyze the Request:** The user wants to identify which numbered sense of "moderate" (marked with `<t></t>`) is used in the provided context. The answer should be only the number.

2.  **Examine the Context:** "Alimta is not recommended for use in patients with <t>moderate</t> or severe kidney problems."

3.  **Analyze the Target Word ("moderate") in Context:** The word "moderate" is used to describe a level of kidney problems that is significant enough to warrant caution or contraindication.

4.  **Evaluate the Senses:**

    *   **Sense 1:** definition=being within reasonable or average limits; not excessive or extreme | examples=moderate prices; a moderate income
    *   **Sense 2:** definition=not extreme | synonyms=temperate | examples=a moderate penalty; temperate in his response to criticism
    *   **Sense 3:** definition=marked by avoidance of extravagance or extremes | synonyms=restrained | examples=moderate in his demands; restrained in his response

5.  **Match Context to Senses:**

    *   The context is about medical conditions (kidney problems).
    *   "Moderate kidney problems" implies a level that is significant but not necessarily the absolute worst (severe). It falls within a range, not an extreme.

    *   *Check Sense 1:* "being within reasonable or average limits; not excessive or extreme." This fits the idea of a level that is within a reasonable range, not extreme.
    *   *Check Sense 2:* "not extreme." This is very close, but Sense 1 emphasizes "reasonable or average limits."
    *   *Check Sense 3:* "marked by avoidance of extravagance or extremes." This relates more to behavior or spending (extravagance), not typically medical conditions, although it could apply metaphorically.

6.  **Determine the Best Fit:** In medical contexts, "moderate" usually means intermediate or average, falling between mild and severe. Sense 1 captures this idea best: "within reasonable or average limits; not excessive or extreme."

7.  **Final Selection:** Sense 1.


[User]
Which numbered sense of "severe" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or <t>severe</t> kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Senses:
1. definition=intensely or extremely bad or unpleasant in degree or quality | synonyms=terrible, wicked | examples=severe pain; a severe case of flu
2. definition=very strong or vigorous | synonyms=hard, knockout | examples=strong winds; a hard left to the chin
3. definition=severely simple | synonyms=austere, stark, stern | examples=a stark interior
4. definition=unsparing and uncompromising in discipline or judgment; - H.G.Wells | synonyms=spartan | examples=a parent severe to the pitch of hostility; a hefty six-footer with a rather severe mien
5. definition=causing fear or anxiety by threatening great harm | synonyms=dangerous, grave, grievous, serious, life-threatening | examples=a dangerous operation; a grave situation
6. definition=very bad in degree or extent | examples=a severe worldwide depression; the house suffered severe damage

reasoning_content:
1.  **Analyze the Request:** The user wants to identify which numbered sense of the word "severe" (marked with `<t></t>`) is used in the provided context.

2.  **Examine the Context:** "Alimta is not recommended for use in patients with moderate or <t>severe</t> kidney problems."

3.  **Determine the Meaning of "severe" in Context:** The context refers to medical conditions (kidney problems) that are serious enough to warrant caution or contraindication for treatment.

4.  **Analyze the Senses Provided:**

    *   **Sense 1:** definition=intensely or extremely bad or unpleasant in degree or quality | synonyms=terrible, wicked | examples=severe pain; a severe case of flu (Focuses on intensity/badness of quality/degree).
    *   **Sense 2:** definition=very strong or vigorous | synonyms=hard, knockout | examples=strong winds; a hard left to the chin (Focuses on strength/vigor).
    *   **Sense 3:** definition=severely simple | synonyms=austere, stark, stern | examples=a stark interior (Focuses on simplicity/starkness).
    *   **Sense 4:** definition=unsparing and uncompromising in discipline or judgment; - H.G.Wells | synonyms=spartan | examples=a parent severe to the pitch of hostility; a hefty six-footer with a rather severe mien (Focuses on strictness/harshness of manner).
    *   **Sense 5:** definition=causing fear or anxiety by threatening great harm | synonyms=dangerous, grave, grievous, serious, life-threatening | examples=a dangerous operation; a grave situation (Focuses on threat/danger/gravity).
    *   **Sense 6:** definition=very bad in degree or extent | examples=a severe worldwide depression; the house suffered severe damage (Focuses on badness/extent/degree).

5.  **Match Context to Senses:**
    *   The context is about kidney problems that are serious enough to be a contraindication.
    *   The phrase "severe kidney problems" means problems of a high degree or extent.

    *   *Check Sense 1:* "intensely or extremely bad or unpleasant in degree or quality." (Fits, but maybe too focused on pain/quality).
    *   *Check Sense 6:* "very bad in degree or extent." (Fits very well, especially when describing a condition like a disease or damage).
    *   *Check Sense 5:* "causing fear or anxiety by threatening great harm." (Possible, but the primary meaning here is the severity of the physical condition, not just the fear it causes).

6.  **Refine the Choice (Comparing 1 and 6):**
    *   "Severe kidney problems" describes the magnitude or extent of the illness.
    *   Sense 6: "very bad in degree or extent." (This is the most direct fit for describing the magnitude of a medical condition).
    *   Sense 1: "intensely or extremely bad or unpleasant in degree or quality." (Also fits, but Sense 6 is more focused on the *extent* of the problem, which is key when discussing medical conditions).

7.  **Conclusion:** Sense 6 is the most appropriate definition for describing the extent/degree of a medical problem.


[User]
Which numbered sense of "problem" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney <t>problems</t>. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Senses:
1. definition=a state of difficulty that needs to be resolved | synonyms=job | examples=she and her husband are having problems; it is always a job to contact him
2. definition=a question raised for consideration or solution | examples=our homework consisted of ten problems to solve
3. definition=a source of difficulty | synonyms=trouble | examples=one trouble after another delayed the job; what's the problem?

reasoning_content:
1.  **Analyze the Request:** The user wants me to identify which numbered sense of "problem" (1, 2, or 3) is used in the context marked by `<t>problems</t>`. I must return only the number.

2.  **Examine the Context:** "Alimta is not recommended for use in patients with moderate or severe kidney problems."

3.  **Analyze the Target Word/Phrase:** "kidney problems".

4.  **Analyze the Senses:**
    *   Sense 1: definition=a state of difficulty that needs to be resolved | synonyms=job | examples=she and her husband are having problems; it is always a job to contact him (Focuses on a state/situation that requires action/resolution).
    *   Sense 2: definition=a question raised for consideration or solution | examples=our homework consisted of ten problems to solve (Focuses on an issue that needs solving/answering).
    *   Sense 3: definition=a source of difficulty | synonyms=trouble | examples=one trouble after another delayed the job; what's the problem? (Focuses on the origin or source of the difficulty/trouble).

5.  **Apply Senses to the Context:**
    *   The context states that patients with kidney problems are not recommended for Alimta. This implies that kidney problems are a *source* or *origin* of difficulty/risk that needs to be managed or avoided.

    *   *Test against Sense 1 (state of difficulty that needs to be resolved):* While kidney problems are a difficulty, the sentence isn't framed as "we need to resolve this problem." It's framed as a contraindication.
    *   *Test against Sense 2 (question raised for consideration or solution):* Not applicable. It's a statement of fact/recommendation, not a question.
    *   *Test against Sense 3 (a source of difficulty):* Kidney problems are the *source* of the contraindication/difficulty regarding the drug's use. This fits the definition of "a source of difficulty" or "trouble."

6.  **Conclusion:** Sense 3 is the most appropriate fit.


[User]
Which numbered sense of "more" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For <t>more</t> information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Senses:
1. definition=(comparative of `much' used with mass nouns) a quantifier meaning greater in size or amount or extent or degree | synonyms=more than | examples=more land; more support
2. definition=(comparative of `many' used with count nouns) quantifier meaning greater in number | examples=a hall with more seats; we have no more bananas

reasoning_content:
1.  **Analyze the Request:** The user wants to know which numbered sense of "more" (marked with <t></t>) is used in the provided context. The answer should be only the number.

2.  **Examine the Context:**
    "It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For <t>more</t> information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?"

3.  **Identify the Target Word:** The target word is "<t>more</t>".

4.  **Analyze the Usage of "more":** The phrase is "For more information".
    *   "Information" is an uncountable (mass) noun.
    *   The structure is "more [uncountable noun]".

5.  **Evaluate the Senses:**

    *   **Sense 1:** definition=(comparative of `much' used with mass nouns) a quantifier meaning greater in size or amount or extent or degree | synonyms=more than | examples=more land; more support
        *   *Check against context:* "more information" fits perfectly. It means a greater amount/extent of information.

    *   **Sense 2:** definition=(comparative of `many' used with count nouns) quantifier meaning greater in number | examples=a hall with more seats; we have no more bananas
        *   *Check against context:* "Information" is not a count noun. This sense does not apply.

6.  **Conclusion:** Sense 1 is the correct usage.

7.  **Final Output Generation:** Return only the number.


[User]
Which numbered sense of "information" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more <t>information</t>, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Senses:
1. definition=a message received and understood | synonyms=info
2. definition=knowledge acquired through study or experience or instruction
3. definition=formal accusation of a crime
4. definition=a collection of facts from which conclusions may be drawn | synonyms=data | examples=statistical data
5. definition=(communication theory) a numerical measure of the uncertainty of an outcome | synonyms=selective information, entropy | examples=the signal contained thousands of bits of information

reasoning_content:
1.  **Analyze the Request:** The user wants to identify which numbered sense of "information" (marked with <t>information</t>) is used in the provided context. The answer should be only the number.

2.  **Examine the Context:**
    "It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?"

3.  **Analyze the Target Word Usage:** The word is "information" in the phrase: "For more information, see the Summary of Product Characteristics..."

4.  **Evaluate the Senses:**

    *   **Sense 1:** definition=a message received and understood | synonyms=info
    *   **Sense 2:** definition=knowledge acquired through study or experience or instruction
    *   **Sense 3:** definition=formal accusation of a crime
    *   **Sense 4:** definition=a collection of facts from which conclusions may be drawn | synonyms=data | examples=statistical data
    *   **Sense 5:** definition=(communication theory) a numerical measure of the uncertainty of an outcome | synonyms=selective information, entropy | examples=the signal contained thousands of bits of information

5.  **Match Usage to Senses:**

    *   The context is a medical/procedural text. The phrase "For more information, see the Summary of Product Characteristics" refers to supplementary details, explanations, and knowledge about the drug.
    *   *Is it Sense 1 (a message received and understood)?* Yes, information is a message.
    *   *Is it Sense 2 (knowledge acquired through study or experience)?* Yes, the Summary of Product Characteristics provides knowledge/instruction.
    *   *Is it Sense 4 (a collection of facts from which conclusions may be drawn)?* While the document contains facts, the *function* of the phrase "For more information" is usually seeking explanatory knowledge or details, not just a raw data set.
    *   *Is it Sense 5 (a numerical measure of uncertainty)?* No, this is clearly not about entropy or bits.

6.  **Refine the Choice between Sense 1 and Sense 2:**
    In common usage, "information" often bridges both definitions. However, when referring to a document or source (like a summary or a report), it usually refers to the content that conveys knowledge or understanding.
    *   Sense 1: Focuses on the *act* of receiving/understanding a message.
    *   Sense 2: Focuses on the *result* (knowledge) gained from that message/study.

    The phrase "For more information, see [document]" is asking for more knowledge/details. Sense 2 ("knowledge acquired through study or experience or instruction") is a very strong fit, as the Summary of Product Characteristics is a source of instruction and knowledge.

7.  **Final Check:** The context is seeking detailed knowledge about a medical treatment. This aligns best with the definition of information as knowledge acquired through study or instruction (Sense 2). (Sense 1 is too general; Sense 4 is too specific to raw data; Sense 5 is entirely wrong.)


[User]
Which numbered sense of "see" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Senses:
1. definition=perceive by sight or have the power to perceive by sight | examples=You have to be a good observer to see all the details; Can you see the bird in that tree?
2. definition=perceive (an idea or situation) mentally | synonyms=understand, realize, realise | examples=Now I see!; I just can't see your point
3. definition=perceive or be contemporaneous with | synonyms=witness, find | examples=We found Republicans winning the offices; You'll see a lot of cheating in this school
4. definition=imagine; conceive of; see in one's mind | synonyms=visualize, visualise, envision, project, fancy, figure | examples=I can't see him on horseback!; I can see what will happen
5. definition=deem to be | synonyms=consider, reckon, view, regard | examples=She views this quite differently from me; I consider her to be shallow
6. definition=get to know or become aware of, usually accidentally | synonyms=learn, hear, get word, get wind, pick up, find out | examples=I learned that she has two grown-up children; I see that you have been promoted
7. definition=see or watch | synonyms=watch, view, catch, take in | examples=view a show on television; This program will be seen all over the world
8. definition=come together | synonyms=meet, run into, encounter, run across, come across | examples=I'll probably see you at the meeting; How nice to see you again!
9. definition=find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, find out, ascertain, watch, learn | examples=I want to see whether she speaks French; See whether it works
10. definition=be careful or certain to do something; make certain of something | synonyms=check, insure, see to it, ensure, control, ascertain | examples=He verified that the valves were closed; See that the curtains are closed
11. definition=go to see for professional or business reasons | examples=You should see a lawyer; We had to see a psychiatrist
12. definition=go to see for a social visit | examples=I went to see my friend Mary the other day
13. definition=go to see a place, as for entertainment | synonyms=visit | examples=We went to see the Eiffel Tower in the morning
14. definition=take charge of or deal with | synonyms=attend, take care, look | examples=Could you see about lunch?; I must attend to this matter
15. definition=receive as a specified guest | examples=the doctor will see you now; The minister doesn't see anybody before noon
16. definition=date regularly; have a steady relationship with | synonyms=go steady, go out, date | examples=Did you know that she is seeing an older man?; He is dating his former wife again!
17. definition=see and understand, have a good eye | examples=The artist must first learn to see
18. definition=deliberate or decide | examples=See whether you can come tomorrow; let's see--which movie should we see tonight?
19. definition=observe as if with an eye | examples=The camera saw the burglary and recorded it
20. definition=observe, check out, and look over carefully or inspect | synonyms=examine | examples=The customs agent examined the baggage; I must see your passport before you can enter the country
21. definition=go or live through | synonyms=experience, go through | examples=We had many trials to go through; he saw action in Viet Nam
22. definition=accompany or escort | synonyms=escort | examples=I'll see you to the door
23. definition=match or meet | examples=I saw the bet of one of my fellow players
24. definition=make sense of; assign a meaning to | synonyms=interpret, construe | examples=What message do you see in this letter?; How do you interpret his behavior?

reasoning_content:
1.  **Analyze the Request:** The goal is to identify which numbered sense of "see" (marked with `<t>see</t>`) is used in the provided context and return only the number.

2.  **Locate the Target Phrase:** The phrase is `<t>see</t>` in the sentence: "For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR)."

3.  **Analyze the Contextual Meaning:** The phrase "see the Summary of Product Characteristics" means to look at, refer to, or consult that document for information.

4.  **Examine the Senses (Focusing on 'see' related to looking/referring):**

    *   1. definition=perceive by sight or have the power to perceive by sight (Physical sight)
    *   7. definition=see or watch (View, catch, take in)
    *   9. definition=find out, learn, or determine with certainty, usually by making an inquiry or other effort (Inquiry/determination)
    *   20. definition=observe, check out, and look over carefully or inspect (Examine)

5.  **Evaluate the Options against the Context:**
    *   The context is directing the reader to a source of information. This is a form of inquiry or finding information.
    *   Sense 9: "find out, learn, or determine with certainty, usually by making an inquiry or other effort." (This fits the function of referring to a document for information.)
    *   Sense 20: "observe, check out, and look over carefully or inspect." (This is also plausible, but Sense 9 emphasizes the *purpose* of the action—to find information.)

6.  **Final Comparison:** When referring to a document or source for information, "see" often functions as a directive to consult or find out. Sense 9 is the strongest fit for "refer to/find information."

    *   *Example check for 9:* "I want to see whether she speaks French; See whether it works." (Here, 'see' means 'check/determine'.)
    *   *Context check:* "For more information, see the Summary..." (Here, 'see' means 'find out/consult' the information.)

7.  **Conclusion:** Sense 9 is the most appropriate definition.


[User]
Which numbered sense of "product" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR). How does Alimta work?

Senses:
1. definition=commodities offered for sale | synonyms=merchandise, ware | examples=good business depends on having good merchandise; that store offers a variety of products
2. definition=an artifact that has been created by someone or some process | synonyms=production | examples=they improve their product every year; they export most of their agricultural production
3. definition=a quantity obtained by multiplication | synonyms=mathematical product | examples=the product of 2 and 3 is 6
4. definition=a chemical substance formed as a result of a chemical reaction | examples=a product of lime and nitric acid
5. definition=a consequence of someone's efforts or of a particular set of circumstances | examples=skill is the product of hours of practice; his reaction was the product of hunger and fatigue
6. definition=the set of elements common to two or more sets | synonyms=intersection, Cartesian product | examples=the set of red hats is the intersection of the set of hats and the set of red things

reasoning_content:
1.  **Analyze the Request:** The goal is to identify which numbered sense of the word "product" (marked with <t>Product</t>) is used in the provided context.

2.  **Examine the Context:**
    "It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR). How does Alimta work?"

3.  **Locate the Target Word:** The target word is "Product" in the phrase "Summary of Product Characteristics".

4.  **Determine the Meaning of "Product" in Context:** In the context of pharmaceuticals (Alimta, cisplatin, side effects, treatment, EPAR), "Product Characteristics" refers to the description, specifications, and details of the drug itself.

5.  **Evaluate the Senses:**

    *   **Sense 1:** definition=commodities offered for sale | synonyms=merchandise, ware | examples=good business depends on having good merchandise; that store offers a variety of products. (Relates to goods/items offered.)
    *   **Sense 2:** definition=an artifact that has been created by someone or some process | synonyms=production | examples=they improve their product every year; they export most of their agricultural production. (Relates to something created/manufactured.)
    *   **Sense 3:** definition=a quantity obtained by multiplication | synonyms=mathematical product | examples=the product of 2 and 3 is 6. (Relates to multiplication.)
    *   **Sense 4:** definition=a chemical substance formed as a result of a chemical reaction | examples=a product of lime and nitric acid. (Relates to a chemical outcome.)
    *   **Sense 5:** definition=a consequence of someone's efforts or of a particular set of circumstances | examples=skill is the product of hours of practice; his reaction was the product of hunger and fatigue. (Relates to an outcome/result.)
    *   **Sense 6:** definition=the set of elements common to two or more sets | synonyms=intersection, Cartesian product | examples=the set of red hats is the intersection of the set of hats and the set of red things. (Relates to set theory.)

6.  **Match Context to Senses:**
    The phrase "Product Characteristics" refers to the characteristics of the manufactured drug (Alimta). This aligns best with the idea of something that has been created or manufactured.

    *   Sense 2: "an artifact that has been created by someone or some process" (Fits the idea of a manufactured drug/item).
    *   Sense 4: "a chemical substance formed as a result of a chemical reaction" (While Alimta is a chemical substance, "Product Characteristics" usually encompasses more than just the chemical formula; it includes usage, safety, etc., making Sense 2 a broader fit for the term "Product").

7.  **Conclusion:** Sense 2 is the most appropriate definition for "product" in the context of a pharmaceutical drug.


[User]
Which numbered sense of "part" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR). How does Alimta work?

Senses:
1. definition=something determined in relation to something that includes it | synonyms=portion, component part, component, constituent | examples=he wanted to feel a part of something bigger than himself; I read a portion of the manuscript
2. definition=something less than the whole of a human artifact | synonyms=portion | examples=the rear part of the house; glue the two parts together
3. definition=a portion of a natural object | synonyms=piece | examples=they analyzed the river into three parts; he needed a piece of granite
4. definition=that which concerns a person with regard to a particular role or situation | examples=it requires vigilance on our part; they resisted every effort on his part
5. definition=the extended spatial location of something | synonyms=region | examples=the farming regions of France; religions in all parts of the world
6. definition=the actions and activities assigned to or required or expected of a person or group | synonyms=function, office, role | examples=the function of a teacher; the government must do its part
7. definition=an actor's portrayal of someone in a play | synonyms=character, role, theatrical role, persona | examples=she played the part of Desdemona
8. definition=assets belonging to or due to or contributed by an individual person or group | synonyms=share, portion, percentage | examples=he wanted his share in cash
9. definition=one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division | examples=the written part of the exam; the finance section of the company
10. definition=a line of scalp that can be seen when sections of hair are combed in opposite directions | synonyms=parting | examples=his part was right in the middle
11. definition=the melody carried by a particular voice or instrument in polyphonic music | synonyms=voice | examples=he tried to sing the tenor part
12. definition=the part played by a person in bringing about a result | synonyms=contribution, share | examples=I am proud of my contribution in advancing the project; they all did their share of the work

reasoning_content:
1.  **Analyze the Request:** The goal is to identify which numbered sense of the word "part" (marked with `<t>part</t>`) is used in the provided context and return only the number.

2.  **Locate the Target Word and Context:**
    The context is: "For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR). How does Alimta work?"

3.  **Analyze the Usage:** The phrase is "part of the EPAR". This usage means a component, a section, or a piece that makes up the whole document (EPAR).

4.  **Examine the Senses:**

    *   **Sense 1:** definition=something determined in relation to something that includes it | synonyms=portion, component part, component, constituent | examples=he wanted to feel a part of something bigger than himself; I read a portion of the manuscript. (Matches the idea of a component/portion.)
    *   **Sense 2:** definition=something less than the whole of a human artifact | synonyms=portion | examples=the rear part of the house; glue the two parts together. (Focuses on a physical section/piece.)
    *   **Sense 3:** definition=a portion of a natural object | synonyms=piece | examples=they analyzed the river into three parts; he needed a piece of granite. (Focuses on a physical section/piece.)
    *   **Sense 4:** definition=that which concerns a person with regard to a particular role or situation. (Focuses on role/function.)
    *   **Sense 5:** definition=the extended spatial location of something | synonyms=region. (Focuses on location.)
    *   **Sense 6:** definition=the actions and activities assigned to or required or expected of a person or group | synonyms=function, office, role. (Focuses on function/role.)
    *   **Sense 7:** definition=an actor's portrayal of someone in a play | synonyms=character, role. (Focuses on acting role.)
    *   **Sense 8:** definition=assets belonging to or due to or contributed by an individual person or group | synonyms=share, portion, percentage. (Focuses on ownership/share.)
    *   **Sense 9:** definition=one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division. (Focuses on a division/section of a whole.)
    *   **Sense 10:** definition=a line of scalp that can be seen when sections of hair are combed in opposite directions | synonyms=parting. (Specific to hair.)
    *   **Sense 11:** definition=the melody carried by a particular voice or instrument in polyphonic music | synonyms=voice. (Specific to music.)
    *   **Sense 12:** definition=the part played by a person in bringing about a result | synonyms=contribution, share. (Focuses on contribution/role in an action.)

5.  **Match Context to Senses:**
    The context uses "part of the EPAR." This implies a section or component of the larger document.

    *   Sense 1: "component," "portion," "constituent." (Strong match.)
    *   Sense 9: "one of the portions into which something is regarded as divided and which together constitute a whole," "section," "division." (Strong match, especially for a document.)

6.  **Refine the Choice (1 vs 9):**
    While Sense 1 (component/portion) is accurate, Sense 9 specifically addresses how a whole (like a document or concept) is divided into constituent sections. In the context of a Summary of Product Characteristics (a formal document), referring to it as a "part" strongly aligns with the meaning of a "section" or "division" that makes up the whole.

    *   Context: Summary of Product Characteristics (EPAR) -> a document.
    *   Sense 9: "one of the portions into which something is regarded as divided and which together constitute a whole."

    Sense 9 is the most precise fit for referring to a section or component of a larger whole (the EPAR).


[User]
Which numbered sense of "active" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. definition=exerting influence or producing a change or effect | examples=an active ingredient
7. definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. definition=(of e.g. volcanos) capable of erupting
13. definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

reasoning_content:
1.  **Analyze the Request:** The goal is to identify which numbered sense of "active" (marked with `<t>active</t>`) is used in the provided context and return only that number.

2.  **Analyze the Context:**
    "The `<t>active</t>` substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

3.  **Examine the Target Word Usage:** The word is "active substance" and "active form."

    *   "The active substance in Alimta..." (Referring to the substance that performs the action/function).
    *   "...converted into an active form that blocks the activity of the enzymes..." (Referring to a form that is functional/doing something).

4.  **Evaluate the Senses against the Context:**

    *   1. definition=tending to become more severe or wider in scope | examples=active tuberculosis (No match)
    *   2. definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready (No match)
    *   3. definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism (Possible, but less direct than others)
    *   4. definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active (No match)
    *   5. definition=characterized by energetic activity | examples=an active toddler; active as a gazelle (Possible, but usually describes a state/characteristic)
    *   6. definition=exerting influence or producing a change or effect | examples=an active ingredient (Strong match: an ingredient that *exerts influence* or *produces a change*.)
    *   7. definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market (Possible, but less specific than 6)
    *   8. definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive (No match)
    *   9. definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions (No match)
    *   10. definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions (No match)
    *   11. definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic (No match)
    *   12. definition=(of e.g. volcanos) capable of erupting (No match)
    *   13. definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos (No match)
    *   14. definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession (No match)

5.  **Conclusion:** Sense 6 ("exerting influence or producing a change or effect") is the best fit, especially when describing an "active ingredient" or a substance that performs a biological function (blocking enzyme activity).


[User]
Which numbered sense of "substance" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=the real physical matter of which a person or thing consists | examples=DNA is the substance of our genes
2. definition=the choicest or most essential or most vital part of some idea or experience | synonyms=kernel, core, center, centre, essence, gist | examples=the gist of the prosecutor's argument; the heart and soul of the Republican Party
3. definition=the idea that is intended | synonyms=meaning | examples=What is the meaning of this proverb?
4. definition=material of a particular kind or constitution | examples=the immune response recognizes invading substances
5. definition=considerable capital (wealth or income) | synonyms=means | examples=he is a man of means
6. definition=what a communication that is about something is about | synonyms=message, content, subject matter
7. definition=a particular kind or species of matter with uniform properties | examples=shigella is one of the most toxic substances known to man

reasoning_content:
1.  **Analyze the Request:** The user wants me to identify which numbered sense of the word "substance" (marked with `<t>substance</t>`) is used in the provided context. I must return only the number.

2.  **Examine the Context:**
    "How does Alimta work? The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

3.  **Determine the Meaning of "substance" in Context:**
    The context discusses a drug (pemetrexed) that is a "cytotoxic medicine." It refers to the active component of the drug that interacts with biological processes (blocking enzymes, affecting DNA/RNA building blocks). Here, "substance" refers to the physical material or chemical entity of the drug.

4.  **Evaluate the Senses:**

    *   **Sense 1:** definition=the real physical matter of which a person or thing consists | examples=DNA is the substance of our genes
        *   *Fit:* This aligns well with referring to the physical matter/chemical entity of a drug (pemetrexed).

    *   **Sense 2:** definition=the choicest or most essential or most vital part of some idea or experience | synonyms=kernel, core, center, essence, gist | examples=the gist of the prosecutor's argument; the heart and soul of the Republican Party
        *   *Fit:* Not applicable. The context is about chemistry/medicine, not abstract ideas.

    *   **Sense 3:** definition=the idea that is intended | synonyms=meaning | examples=What is the meaning of this proverb?
        *   *Fit:* Not applicable.

    *   **Sense 4:** definition=material of a particular kind or constitution | examples=the immune response recognizes invading substances
        *   *Fit:* Possible, but Sense 1 is more direct when referring to a specific chemical compound/medicine.

    *   **Sense 5:** definition=considerable capital (wealth or income) | synonyms=means | examples=he is a man of means
        *   *Fit:* Not applicable.

    *   **Sense 6:** definition=what a communication that is about something is about | synonyms=message, content, subject matter
        *   *Fit:* Not applicable.

    *   **Sense 7:** definition=a particular kind or species of matter with uniform properties | examples=shigella is one of the most toxic substances known to man
        *   *Fit:* This is a strong candidate, as pemetrexed is a specific chemical matter.

5.  **Compare Best Fits (Sense 1 vs. Sense 7):**
    *   Sense 1: "the real physical matter of which a person or thing consists." (Focuses on composition/physical reality.)
    *   Sense 7: "a particular kind or species of matter with uniform properties." (Focuses on classification/chemical type.)

    In the context of pharmacology, when referring to a specific active drug (pemetrexed), both senses apply. However, Sense 1 is the most fundamental definition of "substance" as a physical entity. Sense 7 is also very accurate, describing pemetrexed as a specific type of matter.

    Let's re-read the examples provided for Sense 1: "DNA is the substance of our genes." (DNA is physical matter.)
    Let's re-read the examples provided for Sense 7: "shigella is one of the most toxic substances known to man." (Shigella is a specific type of matter.)

    The context is discussing the *active substance* (pemetrexed). This is a physical chemical entity. Sense 1 is the most general and accurate definition for identifying a chemical compound.

6.  **Final Selection:** Sense 1.


[User]
Which numbered sense of "medicine" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

reasoning_content:
1.  **Analyze the Request:** The user wants to identify which numbered sense of "medicine" (marked with `<t></t>`) is used in the provided context. The answer should be only the number.

2.  **Examine the Context:**
    "The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites."

3.  **Analyze the Target Word/Phrase:** The word is "medicine" used in the phrase "cytotoxic medicine (a medicine that kills cells...)".

4.  **Evaluate the Senses:**

    *   **Sense 1:** definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty. (Focuses on the *science/field*.)
    *   **Sense 2:** definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug. (Focuses on the *substance/treatment*.)
    *   **Sense 3:** definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard. (Focuses on the *profession/practice*.)
    *   **Sense 4:** definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine. (Focuses on *punishment*.)

5.  **Match Context to Senses:**
    The context uses "cytotoxic medicine" and immediately defines it as "a medicine that kills cells." This refers to a substance or treatment used to treat a disease (cancer cells).

    *   Sense 1 (Branches of science) - Incorrect.
    *   Sense 2 (Something that treats or prevents or alleviates the symptoms of disease) - Correct.
    *   Sense 3 (Learned profession) - Incorrect.
    *   Sense 4 (Punishment) - Incorrect.

6.  **Conclusion:** The context uses the sense of medicine as a treatment or medication. This corresponds to sense number 2.


[User]
Which numbered sense of "medicine" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

reasoning_content:
1.  **Analyze the Request:** The user wants to identify which numbered sense of "medicine" (marked with `<t>medicine</t>`) is used in the provided context.

2.  **Locate the Target Word and Context:**
    *   Target word: `<t>medicine</t>`
    *   Context sentence: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites."

3.  **Analyze the Usage of "medicine" in Context:**
    *   The phrase is "a cytotoxic medicine (a medicine that kills cells...)."
    *   Here, "medicine" refers to a substance/drug (pemetrexed/Alimta) that has a specific therapeutic effect (killing cells).

4.  **Evaluate the Senses:**

    *   **Sense 1:** definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty. (Focuses on the *science/field*.)
    *   **Sense 2:** definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug. (Focuses on the *substance/treatment*.)
    *   **Sense 3:** definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard. (Focuses on the *profession/practice*.)
    *   **Sense 4:** definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine. (Focuses on *punishment*.)

5.  **Match Usage to Sense:**
    *   The context uses "cytotoxic medicine" to describe a substance that kills cells. This aligns perfectly with the definition of a substance that treats or prevents disease symptoms (Sense 2: medication, medicinal drug).

6.  **Conclusion:** The correct sense is 2.


[User]
Which numbered sense of "kill" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=cause to die; put to death, usually intentionally or knowingly | examples=This man killed several people when he tried to rob a bank; The farmer killed a pig for the holidays
2. definition=thwart the passage of | synonyms=shoot down, defeat, vote down, vote out | examples=kill a motion; he shot down the student's proposal
3. definition=end or extinguish by forceful means | synonyms=stamp out | examples=Stamp out poverty!
4. definition=be fatal | examples=cigarettes kill; drunken driving kills
5. definition=be the source of great pain for | examples=These new shoes are killing me!
6. definition=overwhelm with hilarity, pleasure, or admiration | examples=The comedian was so funny, he was killing me!
7. definition=hit with so much force as to make a return impossible, in racket games | examples=She killed the ball
8. definition=hit with great force | examples=He killed the ball
9. definition=deprive of life | examples=AIDS has killed thousands in Africa
10. definition=cause the death of, without intention | examples=She was killed in the collision of three cars
11. definition=drink down entirely | synonyms=toss off, pop, bolt down, belt down, pour down, down | examples=He downed three martinis before dinner; She killed a bottle of brandy that night
12. definition=mark for deletion, rub off, or erase | synonyms=obliterate, wipe out | examples=kill these lines in the President's speech
13. definition=tire out completely | examples=The daily stress of her work is killing her
14. definition=cause to cease operating | examples=kill the engine
15. definition=destroy a vitally essential quality of or in | examples=Eating artichokes kills the taste of all other foods

reasoning_content:
1.  **Analyze the Request:** The goal is to identify which numbered sense of the word "kill" (marked with `<t>kills</t>`) is used in the provided context.

2.  **Examine the Context:**
    "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells), which belongs to the group antimetabolites."

3.  **Analyze the Usage in Context:** The sentence describes a medicine (pemetrexed) that acts upon cells, causing them to cease dividing or die. The core meaning here is destruction or causing death/cessation of life for a biological entity (cells).

4.  **Evaluate the Senses:**

    *   **1. definition=cause to die; put to death, usually intentionally or knowingly | examples=This man killed several people when he tried to rob a bank; The farmer killed a pig for the holidays** (This involves causing death. Relevant.)
    *   **2. definition=thwart the passage of | synonyms=shoot down, defeat, vote down, vote out | examples=kill a motion; he shot down the student's proposal** (Not relevant.)
    *   **3. definition=end or extinguish by forceful means | synonyms=stamp out | examples=Stamp out poverty!** (Possible, but usually refers to abstract things or large-scale issues, not typically cellular action.)
    *   **4. definition=be fatal | examples=cigarettes kill; drunken driving kills** (Focuses on the result, not the action of killing.)
    *   **5. definition=be the source of great pain for examples=These new shoes are killing me!** (Not relevant.)
    *   **6. definition=overwhelm with hilarity, pleasure, or admiration examples=The comedian was so funny, he was killing me!** (Not relevant.)
    *   **7. definition=hit with so much force as to make a return impossible, in racket games examples=She killed the ball** (Not relevant.)
    *   **8. definition=hit with great force examples=He killed the ball** (Not relevant.)
    *   **9. definition=deprive of life examples=AIDS has killed thousands in Africa** (Very close to 1, focuses on the removal of life.)
    *   **10. definition=cause the death of, without intention examples=She was killed in the collision of three cars** (Focuses on lack of intention, which is not implied here.)
    *   **11. definition=drink down entirely examples=He downed three martinis before dinner; She killed a bottle of brandy that night** (Not relevant.)
    *   **12. definition=mark for deletion, rub off, or erase examples=kill these lines in the President's speech** (Not relevant.)
    *   **13. definition=tire out completely examples=The daily stress of her work is killing her** (Not relevant.)
    *   **14. definition=cause to cease operating examples=kill the engine** (Not relevant.)
    *   **15. definition=destroy a vitally essential quality of or in examples=Eating artichokes kills the taste of all other foods** (Not relevant.)

5.  **Compare the Best Candidates (1 and 9):**
    *   Context: "kills cells that are dividing" (biological destruction/death).
    *   Sense 1: "cause to die; put to death." (Fits the biological context.)
    *   Sense 9: "deprive of life." (Also fits the biological context.)

    In the context of medicine and cytotoxic agents, "killing cells" is fundamentally about causing death. Sense 1 is the most direct definition of causing death.

6.  **Conclusion:** Sense 1 is the most appropriate fit.


[User]
Which numbered sense of "cell" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=any small compartment | examples=the cells of a honeycomb
2. definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. definition=small room in which a monk or nun lives | synonyms=cubicle
7. definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

reasoning_content:
1.  **Analyze the Request:** The user wants to identify which numbered sense of "cell" (marked with `<t>cells</t>`) is used in the provided context. I must return only the number.

2.  **Analyze the Context:**
    "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

3.  **Analyze the Target Word/Phrase:** The word is "cells".

4.  **Evaluate the Senses:**

    *   **Sense 1:** definition=any small compartment | examples=the cells of a honeycomb
        *   *Relevance:* This is a biological definition of a cell.

    *   **Sense 2:** definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
        *   *Relevance:* This is the formal, comprehensive biological definition of a cell.

    *   **Sense 3:** definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
        *   *Relevance:* Refers to an "electric cell," not a biological cell.

    *   **Sense 4:** definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
        *   *Relevance:* Refers to a political "cell," not a biological cell.

    *   **Sense 5:** definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
        *   *Relevance:* Refers to a "cellular" phone, not a biological cell.

    *   **Sense 6:** definition=small room in which a monk or nun lives | synonyms=cubicle
        *   *Relevance:* Refers to a room, not a biological cell.

    *   **Sense 7:** definition=a room where a prisoner is kept | synonyms=jail cell, prison cell
        *   *Relevance:* Refers to a room, not a biological cell.

5.  **Determine the Best Fit:** The context is discussing chemotherapy (pemetrexed) and its action on dividing cells (cancer cells). This is a biological context. Both Sense 1 and Sense 2 are biological definitions.

    *   Sense 1: "any small compartment" (General, but accurate).
    *   Sense 2: "the basic structural and functional unit of all organisms" (The most precise, formal, and comprehensive definition used in scientific literature).

    Since the text is highly scientific (discussing cytotoxic medicine, nucleotides, DNA, RNA), Sense 2 is the most appropriate and intended meaning.

6.  **Final Check:** The context uses "cells" in the context of biological function (killing dividing cells). Sense 2 defines the biological unit.


[User]
Which numbered sense of "divide" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire after World War I
2. definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven?
3. definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries
4. definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated
5. definition=make a division or separation | synonyms=separate
6. definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea

reasoning_content:
1.  **Analyze the Request:** The user wants to identify which numbered sense of "divide" (marked with `<t>dividing</t>`) is used in the provided context.

2.  **Locate the Target Word/Phrase:** The target is `<t>dividing</t>` in the context: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells)..."

3.  **Analyze the Contextual Meaning:** The phrase is "cells that are dividing." This refers to the biological process where cells are actively splitting or multiplying.

4.  **Examine the Senses:**

    *   **Sense 1:** definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire after World War I (Focus: separating into parts/portions).
    *   **Sense 2:** definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven? (Focus: mathematical division/fraction).
    *   **Sense 3:** definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries (Focus: acting as a barrier/separation).
    *   **Sense 4:** definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated (Focus: physical separation/coming apart).
    *   **Sense 5:** definition=make a division or separation | synonyms=separate (Focus: creating a division/separation).
    *   **Sense 6:** definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea (Focus: forceful separation/pulling apart).

5.  **Match Context to Senses:**
    *   The context is about cells undergoing cell division (mitosis/cell cycle).
    *   Sense 2 is mathematical division. (Incorrect)
    *   Sense 3 is acting as a barrier. (Incorrect)
    *   Sense 4 is coming apart (physical separation). (Less accurate than the biological process).
    *   Sense 5 is making a division or separation. (Plausible, but let's check the core meaning).
    *   Sense 6 is forcing/pulling apart. (Incorrect).
    *   Sense 1 is separating into parts or portions. (This aligns well with the concept of a cell dividing into two parts).

6.  **Refine the Match (Focus on Biological Division):** When we say a cell is "dividing," we are referring to the process of splitting or separating into two or more new cells. Sense 1 ("separate into parts or portions") captures this idea of splitting/partitioning.

7.  **Final Check:** The context states the medicine kills cells that are *dividing*. This is a biological division process. Sense 1 is the best fit among the options provided for the concept of splitting or partitioning.