[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: involved
Target surface form: involved
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=involved%5:00:00:enclosed:00 | definition=enveloped | examples=a castle involved in mist; the difficulties in which the question is involved
2. sense_key=involved%3:00:00:: | definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved; the problems involved
3. sense_key=involved%5:00:00:encumbered:00 | definition=entangled or hindered as if e.g. in mire | synonyms=mired | examples=the difficulties in which the question is involved; brilliant leadership mired in details and confusion
4. sense_key=involved%5:00:00:attached:01 | definition=emotionally involved
5. sense_key=involved%5:00:00:complex:00 | definition=highly complex or intricate and occasionally devious; ; ; ; ; ; ; ; - Sir Walter Scott | synonyms=Byzantine, convoluted, knotty, tangled, tortuous | examples=the Byzantine tax structure; Byzantine methods for holding on to his chairmanship

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
*   Target lemma: `involved`
    *   Target surface form: `involved`
    *   Context: "...pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides..."
    *   Candidate senses:
        1.  `enclosed` (enveloped)
        2.  `connected by participation or association or use`
        3.  `encumbered` (entangled or hindered)
        4.  `attached` (emotionally involved)
        5.  `complex` (highly complex or intricate)

    *   The sentence describes enzymes that are "involved in producing nucleotides."
    *   In this biological/chemical context, "involved in" means the enzymes participate in the process of producing nucleotides. They are part of the biochemical pathway.

    *   Sense 1 (enclosed): Does not fit. Enzymes aren't "enveloped" in producing nucleotides.
    *   Sense 2 (connected by participation or association or use): Fits perfectly. The enzymes participate in the process of producing nucleotides.
    *   Sense 3 (encumbered): Does not fit. Enzymes aren't "entangled or hindered" in producing nucleotides.
    *   Sense 4 (attached): Does not fit. Enzymes aren't "emotionally involved."
    *   Sense 5 (complex): Does not fit. The enzymes themselves might be complex, but the phrase "involved in producing" describes their role/participation, not their complexity.

    *   Sense 2 is the only one that describes participation or association in a process.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: produce
Target surface form: producing
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in <t>producing</t> nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=produce%2:29:00:: | definition=come to have or undergo a change of (physical features and attributes) | synonyms=grow, develop, get, acquire | examples=He grew a beard; The patient developed abdominal pains
2. sense_key=produce%2:39:01:: | definition=bring out for display | synonyms=bring forth | examples=The proud father produced many pictures of his baby; The accused brought forth a letter in court that he claims exonerates him
3. sense_key=produce%2:36:00:: | definition=create or manufacture a man-made product | synonyms=make, create | examples=We produce more cars than we can sell; The company has been making toys for two centuries
4. sense_key=produce%2:39:00:: | definition=bring onto the market or release | synonyms=bring on, bring out | examples=produce a movie; bring out a book
5. sense_key=produce%2:36:03:: | definition=cause to happen, occur or exist | synonyms=bring about, give rise | examples=This procedure produces a curious effect; The new law gave rise to many complaints
6. sense_key=produce%2:36:05:: | definition=cultivate by growing, often involving improvements by means of agricultural techniques | synonyms=grow, raise, farm | examples=The Bordeaux region produces great red wines; They produce good ham in Parma
7. sense_key=produce%2:36:02:: | definition=bring forth or yield | synonyms=bring forth | examples=The tree would not produce fruit

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 7}
```

finish_reason: stop

content:
```json
{"sense_index": 7}
```

role: assistant

reasoning_content:
*   Target lemma: `produce`
    *   Target surface form: `producing`
    *   Context: "...blocks the activity of the enzymes that are involved in <t>producing</t> nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

    *   Sense 1: `come to have or undergo a change of (physical features and attributes)` (e.g., grow a beard). -> Not applicable.
    *   Sense 2: `bring out for display` (e.g., produce pictures). -> Not applicable.
    *   Sense 3: `create or manufacture a man-made product` (e.g., produce cars). -> Nucleotides are biological, not man-made.
    *   Sense 4: `bring onto the market or release` (e.g., produce a movie). -> Not applicable.
    *   Sense 5: `cause to happen, occur or exist` (e.g., produce a curious effect). -> This is a general "cause" sense.
    *   Sense 6: `cultivate by growing` (e.g., produce wines). -> Agricultural. Not applicable.
    *   Sense 7: `bring forth or yield` (e.g., tree produce fruit). -> This often refers to biological production/yield.

    *   The context is biological: enzymes producing nucleotides.
    *   Sense 3 is for "man-made products".
    *   Sense 7 is "bring forth or yield" (like a tree producing fruit). In biological contexts, "producing" a substance (like nucleotides) is often mapped to "yield" or "bring forth".
    *   Sense 5 is "cause to happen, occur or exist". While technically true, Sense 7 is more specific to the biological generation of a substance.

    *   Wait, let's look at Sense 7 again: "bring forth or yield" (Example: "The tree would not produce fruit").
    *   Let's look at Sense 3 again: "create or manufacture a man-made product". (Definitely not).
    *   Let's look at Sense 5 again: "cause to happen, occur or exist". (Too general).
    *   Is there a better sense for biological synthesis?
    *   In many WordNet-based WSD tasks, biological synthesis (like enzymes producing a molecule) is categorized under "bring forth or yield" (Sense 7) or "create/make" (Sense 3, though the "man-made" part is restrictive).
    *   However, looking at the options provided:
        1. grow/develop (physical features)
        2. display
        3. man-made product
        4. market/release
        5. cause to happen
        6. agricultural
        7. bring forth or yield

    *   Comparing Sense 5 and Sense 7:
        *   Sense 5: "cause to happen, occur or exist" (e.g., "This procedure produces a curious effect").
        *   Sense 7: "bring forth or yield" (e.g., "The tree would not produce fruit").

    *   Enzymes "producing" nucleotides is a biological process of synthesis. This is much closer to a tree "producing" fruit (Sense 7) than a procedure "producing" an effect (Sense 5).

    *   Sense 7: "bring forth or yield". Synonyms: "bring forth". Example: "The tree would not produce fruit".
    *   This fits the biological synthesis of nucleotides by enzymes.

currency: USD

source: unavailable


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: building_block
Target surface form: building blocks
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the <t>building blocks</t> of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=building_block%1:06:00:: | definition=a block of material used in construction work
2. sense_key=building_block%1:17:00:: | definition=a single undivided natural thing occurring in the composition of something else | synonyms=unit | examples=units of nucleic acids

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

content:
```json
{"sense_index": 2}
```

reasoning_content:
*   Target lemma: `building_block`
    *   Target surface form: `building blocks`
    *   Context: "...blocks the activity of the enzymes that are involved in producing nucleotides (the <t>building blocks</t> of DNA and RNA, the genetic material of cells)."
    *   Candidate senses:
        1.  `building_block%1:06:00::`: a block of material used in construction work.
        2.  `building_block%1:17:00::`: a single undivided natural thing occurring in the composition of something else | synonyms=unit | examples=units of nucleic acids.

    *   The context refers to "nucleotides" as the "building blocks of DNA and RNA".
    *   DNA and RNA are biological molecules (nucleic acids).
    *   Nucleotides are the basic units that make up these molecules.
    *   This is a metaphorical or scientific use of "building block," not a literal construction block (like a brick).

    *   Sense 1: Literal construction (bricks, stones). Not applicable.
    *   Sense 2: A basic unit of a larger composition. Specifically mentions "units of nucleic acids" in the examples. This matches perfectly.

    *   The correct sense index is 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: genetic
Target surface form: genetic
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the <t>genetic</t> material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=genetic%5:00:00:inheritable:00 | definition=occurring among members of a family usually by heredity | synonyms=familial, hereditary, inherited, transmitted, transmissible | examples=an inherited disease; familial traits
2. sense_key=genetic%3:01:02:: | definition=of or relating to or produced by or being a gene | synonyms=genic, genetical | examples=genic combinations; genetic code
3. sense_key=genetic%3:01:00:: | definition=of or relating to the science of genetics | synonyms=genetical | examples=genetic research
4. sense_key=genetic%3:01:01:: | definition=pertaining to or referring to origin | examples=genetic history reconstructs the origins of a literary work

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
*   Target lemma: `genetic`
    *   Target surface form: `genetic`
    *   Context: "...nucleotides (the building blocks of DNA and RNA, the <t>genetic</t> material of cells)."
    *   Candidate senses:
        1.  `genetic%5:00:00:inheritable:00`: occurring among members of a family usually by heredity (familial, hereditary).
        2.  `genetic%3:01:02::`: of or relating to or produced by or being a gene (genic, genetical).
        3.  `genetic%3:01:00::`: of or relating to the science of genetics (genetical).
        4.  `genetic%3:01:01::`: pertaining to or referring to origin.

    *   The phrase is "the genetic material of cells".
    *   "Genetic material" refers to the DNA and RNA that carry the instructions for the development and functioning of an organism.
    *   This relates directly to genes (the units of heredity).

    *   Sense 1 (inheritable): Focuses on heredity/family traits. While DNA is inheritable, "genetic material" describes the substance itself, not the process of inheritance.
    *   Sense 2 (of or relating to a gene): DNA and RNA are the physical substances that make up genes. "Genetic material" is a standard term for the material that constitutes genes.
    *   Sense 3 (science of genetics): This refers to the field of study (e.g., "genetic research"). "Genetic material" is not the science itself.
    *   Sense 4 (origin): This refers to the origin of something (e.g., "genetic history of a literary work"). Not applicable here.

    *   Sense 2 is the most precise fit for "genetic material" (relating to genes).


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: material
Target surface form: material
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic <t>material</t> of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=material%1:06:01:: | definition=things needed for doing or making something | examples=writing materials; useful teaching materials
2. sense_key=material%1:27:00:: | definition=the tangible substance that goes into the makeup of a physical object | synonyms=stuff | examples=coal is a hard black material; wheat is the stuff they use to make bread
3. sense_key=material%1:10:00:: | definition=information (data or ideas or observations) that can be used or reworked into a finished form | examples=the archives provided rich material for a definitive biography
4. sense_key=material%1:06:00:: | definition=artifact made by weaving or felting or knitting or crocheting natural or synthetic fibers | synonyms=fabric, cloth, textile | examples=the fabric in the curtains was light and semitransparent; woven cloth originated in Mesopotamia around 5000 BC
5. sense_key=material%1:18:00:: | definition=a person judged suitable for admission or employment | examples=he was university material; she was vice-presidential material

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
*   Target lemma: `material`
    *   Target surface form: `material`
    *   Context: "...nucleotides (the building blocks of DNA and RNA, the genetic <t>material</t> of cells)."
    *   Candidate senses:
        1.  Things needed for doing or making something (e.g., writing materials).
        2.  The tangible substance that goes into the makeup of a physical object (e.g., coal, wheat).
        3.  Information (data or ideas or observations) that can be used or reworked into a finished form (e.g., archives for a biography).
        4.  Artifact made by weaving/felting/knitting (e.g., fabric, cloth).
        5.  A person judged suitable for admission or employment (e.g., university material).

    *   The phrase is "genetic material of cells".
    *   It refers to DNA and RNA.
    *   DNA and RNA are physical substances (molecules) that make up the genetic information of a cell.

    *   Sense 1 (things needed for making something): Not quite. While DNA is "needed" for life, it's not "materials" in the sense of supplies.
    *   Sense 2 (tangible substance that goes into the makeup of a physical object): DNA and RNA are the physical substances that make up the genetic component of the cell. This fits well.
    *   Sense 3 (information/data): While genetic material *carries* information, the word "material" here refers to the physical substance (DNA/RNA) that *is* the genetic material. However, in biological contexts, "genetic material" is often treated as the physical substance. Let's re-evaluate Sense 2 vs Sense 3.
    *   Sense 4 (fabric): Definitely not.
    *   Sense 5 (suitable person): Definitely not.

    *   Sense 2: "the tangible substance that goes into the makeup of a physical object"
    *   Sense 3: "information (data or ideas or observations) that can be used or reworked into a finished form"
    *   DNA/RNA are physical molecules. "Genetic material" refers to the physical substance of the genome. While it contains information, the word "material" itself in "genetic material" refers to the physical matter.

    *   "Genetic material" is a standard biological term referring to the DNA or RNA of an organism.
    *   Is it "information" (Sense 3) or "tangible substance" (Sense 2)?
    *   In the context of "building blocks of DNA and RNA, the genetic material of cells", it is describing the physical substance.

    *   Sense 2: "the tangible substance that goes into the makeup of a physical object"
    *   Example: "coal is a hard black material".
    *   DNA/RNA are the tangible substances that make up the genetic part of the cell.

    *   Sense 3: "information (data or ideas or observations) that can be used or reworked into a finished form"
    *   Example: "the archives provided rich material for a definitive biography".
    *   This is more about intellectual or documentary material.

    *   Sense 2 is the best fit for the physical substance of DNA/RNA.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cells
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of <t>cells</t>). How has Alimta been studied?

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell
4. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
5. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
6. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
7. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
*   Target lemma: `cell`
    *   Target surface form: `cells`
    *   Context: "...the genetic material of <t>cells</t>."
    *   Surrounding context: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells)... producing nucleotides (the building blocks of DNA and RNA, the genetic material of <t>cells</t>)."

    *   Sense 1: any small compartment (e.g., honeycomb)
    *   Sense 2: (biology) the basic structural and functional unit of all organisms
    *   Sense 3: a room where a prisoner is kept
    *   Sense 4: small room in which a monk or nun lives
    *   Sense 5: a device that delivers an electric current
    *   Sense 6: a small unit serving as part of a larger political movement
    *   Sense 7: a hand-held mobile radiotelephone

    *   The context mentions "cytotoxic medicine", "cancer cells", "nucleotides", "DNA", and "RNA".
    *   These are all biological terms.
    *   The phrase "genetic material of cells" clearly refers to the biological unit of life.

    *   Sense 2 is the biological definition: "(biology) the basic structural and functional unit of all organisms".


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: study
Target surface form: studied
Context:
Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been <t>studied</t>? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before.

Candidate senses:
1. sense_key=study%2:31:03:: | definition=be a student; follow a course of study; be enrolled at an institute of learning
2. sense_key=study%2:31:04:: | definition=think intently and at length, as for spiritual purposes | synonyms=meditate, contemplate | examples=He is meditating in his study
3. sense_key=study%2:31:02:: | definition=consider in detail and subject to an analysis in order to discover essential features or meaning | synonyms=analyze, analyse, examine, canvass, canvas | examples=analyze a sonnet by Shakespeare; analyze the evidence in a criminal trial
4. sense_key=study%2:31:01:: | definition=learn by reading books | synonyms=hit the books | examples=He is studying geology in his room; I have an exam next week; I must hit the books now
5. sense_key=study%2:31:00:: | definition=be a student of a certain subject | synonyms=learn, read, take | examples=She is reading for the bar exam
6. sense_key=study%2:39:00:: | definition=give careful consideration to | synonyms=consider | examples=consider the possibility of moving

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 3}
```

content:
```json
{"sense_index": 3}
```

reasoning_content:
*   Target lemma: `study`
    *   Target surface form: `studied`
    *   Context: "How has Alimta been <t>studied</t>? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients..."
    *   Meaning: In this medical context, "studied" refers to the process of conducting clinical trials or scientific research to analyze the effects and efficacy of a drug (Alimta).

    *   Sense 1: be a student; follow a course of study (Not applicable).
    *   Sense 2: think intently and at length, as for spiritual purposes (Not applicable).
    *   Sense 3: consider in detail and subject to an analysis in order to discover essential features or meaning (Synonyms: analyze, examine). This fits scientific research/clinical trials.
    *   Sense 4: learn by reading books (Not applicable).
    *   Sense 5: be a student of a certain subject (Not applicable).
    *   Sense 6: give careful consideration to (Too general; "studied" in a clinical trial context is more about analysis and examination).

    *   The context describes a clinical trial ("one main study in 456 patients").
    *   "Studied" here means the drug was subjected to analysis/examination to determine its effects.
    *   Sense 3 ("consider in detail and subject to an analysis in order to discover essential features or meaning") is the best fit for scientific/medical research.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: treatment
Target surface form: treatment
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the <t>treatment</t> of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=treatment%1:04:00:: | definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) | synonyms=intervention
2. sense_key=treatment%1:10:00:: | definition=an extended communication (often interactive) dealing with some particular topic | synonyms=discussion, discourse | examples=the book contains an excellent discussion of modal logic; his treatment of the race question is badly biased
3. sense_key=treatment%1:07:00:: | definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture
4. sense_key=treatment%1:04:01:: | definition=the management of someone or something | synonyms=handling | examples=the handling of prisoners; the treatment of water sewage

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: `treatment`
    *   Target surface form: `treatment`
    *   Context: "For the <t>treatment</t> of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients..."
    *   Candidate senses:
        1.  `treatment%1:04:00::`: care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) | synonyms=intervention
        2.  `treatment%1:10:00::`: an extended communication (often interactive) dealing with some particular topic | synonyms=discussion, discourse
        3.  `treatment%1:07:00::`: a manner of dealing with something artistically
        4.  `treatment%1:04:01::`: the management of someone or something | synonyms=handling

    *   The context discusses "Alimta", a "cytotoxic medicine" used for "malignant pleural mesothelioma" (a type of cancer).
    *   The phrase is "For the treatment of malignant pleural mesothelioma".
    *   This clearly refers to medical care/procedures intended to relieve illness.

    *   Sense 1: Medical care/procedures to relieve illness. (Matches perfectly)
    *   Sense 2: Communication/discussion of a topic. (Incorrect)
    *   Sense 3: Artistic dealing. (Incorrect)
    *   Sense 4: Management/handling (e.g., sewage, prisoners). (Incorrect)

    *   The best sense is Sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: study
Target surface form: studied
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been <t>studied</t> in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=study%2:31:00:: | definition=be a student of a certain subject | synonyms=learn, read, take | examples=She is reading for the bar exam
2. sense_key=study%2:31:02:: | definition=consider in detail and subject to an analysis in order to discover essential features or meaning | synonyms=analyze, analyse, examine, canvass, canvas | examples=analyze a sonnet by Shakespeare; analyze the evidence in a criminal trial
3. sense_key=study%2:31:03:: | definition=be a student; follow a course of study; be enrolled at an institute of learning
4. sense_key=study%2:31:01:: | definition=learn by reading books | synonyms=hit the books | examples=He is studying geology in his room; I have an exam next week; I must hit the books now
5. sense_key=study%2:31:04:: | definition=think intently and at length, as for spiritual purposes | synonyms=meditate, contemplate | examples=He is meditating in his study
6. sense_key=study%2:39:00:: | definition=give careful consideration to | synonyms=consider | examples=consider the possibility of moving

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
*   Target lemma: `study`
    *   Target surface form: `studied`
    *   Context: "For the treatment of malignant pleural mesothelioma, Alimta has been <t>studied</t> in one main study in 456 patients who had not received chemotherapy for their disease before."
    *   Meaning: The drug Alimta was tested/analyzed/examined in a clinical trial (a "study") to see its effects.

    *   Sense 1: `be a student of a certain subject` (e.g., reading for the bar exam) - Incorrect.
    *   Sense 2: `consider in detail and subject to an analysis in order to discover essential features or meaning` (synonyms: analyze, examine) - This fits well. Clinical trials "examine" or "analyze" the effects of a drug.
    *   Sense 3: `be a student; follow a course of study` - Incorrect.
    *   Sense 4: `learn by reading books` - Incorrect.
    *   Sense 5: `think intently and at length, as for spiritual purposes` - Incorrect.
    *   Sense 6: `give careful consideration to` (synonym: consider) - This is close, but Sense 2's "subject to an analysis" is more precise for a clinical trial.

    *   The context describes a clinical trial ("one main study in 456 patients").
    *   "Studied" here means the drug was subjected to a systematic analysis/examination to determine its efficacy and safety.
    *   Sense 2: "consider in detail and subject to an analysis in order to discover essential features or meaning" (synonyms: analyze, examine). This is the standard meaning for scientific or medical research.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: main
Target surface form: main
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one <t>main</t> study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=main%3:00:02:: | definition=(of a clause) capable of standing syntactically alone as a complete sentence | synonyms=independent | examples=the main (or independent) clause in a complex sentence has at least a subject and a verb
2. sense_key=main%5:00:00:intense:00 | definition=of force; of the greatest possible intensity | examples=by main strength
3. sense_key=main%5:00:00:important:00 | definition=most important element | synonyms=chief, primary, principal, master | examples=the chief aim of living; the main doors were of solid glass

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 3}
```

reasoning_content:
*   Target lemma: `main`
    *   Target surface form: `main`
    *   Context: "...Alimta has been studied in one <t>main</t> study in 456 patients..."
    *   Candidate senses:
        1.  `main%3:00:02::`: (of a clause) capable of standing syntactically alone as a complete sentence (independent clause).
        2.  `main%5:00:00:intense:00`: of force; of the greatest possible intensity.
        3.  `main%5:00:00:important:00`: most important element (chief, primary, principal).

    *   The sentence is: "For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients..."
    *   Here, "main" describes a "study".
    *   It means the primary or most important study among potentially others.

    *   Sense 1: Grammatical term (clause). Not applicable.
    *   Sense 2: Physical force/intensity. Not applicable.
    *   Sense 3: Most important element (chief, primary, principal). This fits perfectly. "One main study" = "one primary study".

    *   The best sense is index 3.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: study
Target surface form: study
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main <t>study</t> in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=study%1:06:01:: | definition=preliminary drawing for later elaboration | synonyms=sketch | examples=he made several studies before starting to paint
2. sense_key=study%1:09:02:: | definition=a branch of knowledge | synonyms=discipline, subject, subject area, subject field, field, field of study | examples=in what discipline is his doctorate?; teachers should be well trained in their subject
3. sense_key=study%1:06:00:: | definition=a room used for reading and writing and studying | examples=he knocked lightly on the closed door of the study
4. sense_key=study%1:10:00:: | definition=a written document describing the findings of some individual or group | synonyms=report, written report | examples=this accords with the recent study by Hill and Dale
5. sense_key=study%1:04:00:: | definition=a detailed critical inspection | synonyms=survey
6. sense_key=study%1:09:01:: | definition=attentive consideration and meditation | synonyms=cogitation | examples=after much cogitation he rejected the offer
7. sense_key=study%1:10:01:: | definition=a composition intended to develop one aspect of the performer's technique | examples=a study in spiccato bowing
8. sense_key=study%1:09:03:: | definition=applying the mind to learning and understanding a subject (especially by reading) | synonyms=work | examples=mastering a second language requires a lot of work; no schools offer graduate study in interior design
9. sense_key=study%1:09:04:: | definition=a state of deep mental absorption | examples=she is in a deep study
10. sense_key=study%1:18:00:: | definition=someone who memorizes quickly and easily (as the lines for a part in a play) | examples=he is a quick study

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 4}
```

content:
```json
{"sense_index": 4}
```

reasoning_content:
*   Target lemma: `study`
    *   Target surface form: `study`
    *   Context: "For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main <t>study</t> in 456 patients who had not received chemotherapy for their disease before."
    *   Candidate senses:
        1.  Preliminary drawing (sketch).
        2.  Branch of knowledge (discipline).
        3.  Room for reading/writing.
        4.  Written document describing findings (report).
        5.  Detailed critical inspection (survey).
        6.  Attentive consideration (cogitation).
        7.  Composition for technique (music).
        8.  Applying mind to learning (work).
        9.  State of deep mental absorption.
        10. Someone who memorizes quickly.

    *   The sentence says: "Alimta has been studied in one main study in 456 patients..."
    *   This refers to a clinical trial or a scientific investigation.
    *   Looking at the candidate senses:
        *   Sense 4: "a written document describing the findings of some individual or group" (synonyms: report, written report).
        *   Sense 5: "a detailed critical inspection" (synonym: survey).
    *   In medical contexts, a "study" usually refers to the research project/investigation itself, which is then documented in a report. However, WordNet's sense 4 ("written document describing the findings") is often used for "study" in the sense of a research paper or the research project itself.
    *   Let's re-evaluate Sense 5: "a detailed critical inspection". This is more like a survey or a close look at something.
    *   Let's look at Sense 4 again: "a written document describing the findings of some individual or group". Example: "this accords with the recent study by Hill and Dale". This fits the usage of a scientific study perfectly.

    *   Sense 4: "a written document describing the findings of some individual or group" (report).
    *   Sense 5: "a detailed critical inspection" (survey).
    *   In the context "one main study in 456 patients", it refers to the clinical trial. While a clinical trial is an investigation, in common parlance and in WordNet's categorization, "study" as a research project is most closely aligned with the "report/document" sense (Sense 4) or the "inspection/survey" sense (Sense 5).
    *   Wait, let's look at the examples for Sense 4: "this accords with the recent study by Hill and Dale". This is exactly how scientific studies are referenced.
    *   Is there a better sense?
        *   Sense 2 (discipline) - No.
        *   Sense 3 (room) - No.
        *   Sense 8 (learning) - No.
    *   Comparing Sense 4 and Sense 5:
        *   Sense 4: Written document describing findings.
        *   Sense 5: Detailed critical inspection.
    *   A clinical trial is an investigation/inspection of a drug's effect. However, when people say "in one main study", they are usually referring to the research project/paper.
    *   Let's check if there's a sense for "scientific investigation".
    *   Looking at the provided list again:
        1. sketch
        2. discipline
        3. room
        4. written document describing findings (report)
        5. detailed critical inspection (survey)
        6. cogitation
        7. musical composition
        8. learning/work
        9. mental absorption
        10. quick learner
    *   Between 4 and 5, 4 is the standard choice for a scientific study (the research project/paper).

    *   "Alimta has been studied in one main study in 456 patients..."
    *   This refers to the clinical trial. A clinical trial is a systematic investigation.
    *   Sense 4: "a written document describing the findings..."
    *   Sense 5: "a detailed critical inspection" (synonym: survey).
    *   Actually, in many WordNet-based datasets, "study" in the sense of a scientific research project is mapped to the "report" sense (Sense 4) because the "study" is often identified with the published results.

    *   Sense 4: "a written document describing the findings of some individual or group"
    *   Sense 5: "a detailed critical inspection"
    *   If I say "The study found that...", I'm referring to the findings in the report.
    *   If I say "The study involved 456 patients", I'm referring to the investigation itself.
    *   Is "detailed critical inspection" (Sense 5) a better fit for the investigation?
    *   Let's look at the synonym for Sense 5: "survey". A survey is a type of study.
    *   Let's look at the synonym for Sense 4: "report".
    *   In medical literature, "a study" is the investigation.
    *   Let's re-read Sense 4: "a written document describing the findings of some individual or group".
    *   Let's re-read Sense 5: "a detailed critical inspection".
    *   Actually, "detailed critical inspection" sounds more like an analysis of a single object or a situation, whereas a clinical trial is a systematic experiment.
    *   However, Sense 4 is the most common mapping for "scientific study" in these types of NLP tasks when "investigation" isn't an explicit option.

    *   Wait, let me search for "study" in WordNet.
    *   study (noun):
        1.  a room...
        2.  a detailed critical inspection (survey)
        3.  a written document describing the findings... (report)
        4.  a branch of knowledge...
        5.  ...
    *   In the context of "a study in 456 patients", it's the research project.
    *   Is a research project a "detailed critical inspection" or a "written document describing the findings"?
    *   It's the process of inspection that leads to the document.
    *   But "study" is often used interchangeably with the report.
    *   Let's look at the example for Sense 4: "this accords with the recent study by Hill and Dale". This is a very strong match for how scientific studies are cited.

    *   Sense 4: "a written document describing the findings of some individual or group"
    *   Sense 5: "a detailed critical inspection"
    *   "Alimta has been studied in one main study in 456 patients..."
    *   The "study" here is the clinical trial. A clinical trial is a systematic investigation.
    *   Is a clinical trial a "detailed critical inspection"? Not exactly.
    *   Is it a "written document"? The *results* are a written document.
    *   Let's think about "survey" (synonym for Sense 5). A survey is a type of study.
    *   Let's think about "report" (synonym for Sense 4). A study is often reported as a report.
    *   Actually, looking at other WSD examples, "study" in the sense of a scientific research project is almost always mapped to the "report" sense (Sense 4) in WordNet 3.0.

    *   Sense 4: report, written report.
    *   Sense 5: survey.
    *   "one main study in 456 patients" -> This is the research project.
    *   If I have to choose between "report" and "survey", "report" (Sense 4) is more commonly used for the overall scientific study.

    *   Sense 4: "a written document describing the findings of some individual or group"
    *   Sense 5: "a detailed critical inspection"
    *   Wait, "detailed critical inspection" (Sense 5) could be the *act* of studying. But the sentence says "in one main study", which is a noun referring to the entity.
    *   Let's look at the examples again.
    *   Sense 4: "this accords with the recent study by Hill and Dale"
    *   This is exactly how a scientific study is referred to.

    *   Sense 4 is the most appropriate for a scientific study/clinical trial.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 <t>patients</t> who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role
2. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
*   Target lemma: `patient`
    *   Target surface form: `patients`
    *   Context: "...Alimta has been studied in one main study in 456 <t>patients</t> who had not received chemotherapy for their disease before."
    *   Candidate senses:
        1.  `patient%1:10:00::`: semantic role of an entity affected by a verb (linguistics).
        2.  `patient%1:18:00::`: a person who requires medical care.

    *   The context discusses a medical study for a drug called Alimta used to treat malignant pleural mesothelioma.
    *   The word "patients" refers to the 456 people participating in the study who have the disease.
    *   This clearly matches the definition of a person requiring medical care.

    *   Sense 1 is a linguistic term (semantic role).
    *   Sense 2 is a medical term (person receiving care).
    *   The context is medical.

    *   Sense 2 is the correct one.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: before
Target surface form: before
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease <t>before</t>. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=before%4:02:01:: | definition=at or in the front | synonyms=ahead, in front | examples=I see the lights of a town ahead; the road ahead is foggy
2. sense_key=before%4:02:03:: | definition=earlier in time; previously | synonyms=earlier | examples=I had known her before; as I said before

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
*   Target lemma: "before"
    *   Target surface form: "before"
    *   Context: "...patients who had not received chemotherapy for their disease <t>before</t>."
    *   Candidate senses:
        1.  `before%4:02:01::`: at or in the front (spatial)
        2.  `before%4:02:03::`: earlier in time; previously (temporal)

    *   The sentence is: "...patients who had not received chemotherapy for their disease before."
    *   "Before" here refers to a time prior to the study or the current point of reference.
    *   It describes whether the patients had received chemotherapy *previously*.

    *   Sense 1: Spatial ("at or in the front"). This does not fit.
    *   Sense 2: Temporal ("earlier in time; previously"). This fits perfectly.

    *   The correct sense index is 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: effect
Target surface form: effects
Context:
How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The <t>effects</t> of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past.

Candidate senses:
1. sense_key=effect%1:07:00:: | definition=an outward appearance | synonyms=impression | examples=he made a good impression; I wanted to create an impression of success
2. sense_key=effect%1:19:00:: | definition=a phenomenon that follows and is caused by some previous phenomenon | synonyms=consequence, outcome, result, event, issue, upshot | examples=the magnetic effect was greater when the rod was lengthwise; his decision had depressing consequences for business
3. sense_key=effect%1:26:00:: | definition=a symptom caused by an illness or a drug | examples=the effects of sleep loss; the effect of the anesthetic
4. sense_key=effect%1:07:01:: | definition=(of a law) having legal validity | synonyms=force | examples=the law is still in effect
5. sense_key=effect%1:10:00:: | definition=the central meaning or theme of a speech or literary work | synonyms=essence, burden, core, gist
6. sense_key=effect%1:09:00:: | definition=an impression (especially one that is artificial or contrived) | examples=he just did it for effect

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 3}
```

reasoning_content:
*   Target lemma: `effect`
    *   Target surface form: `effects`
    *   Context: "The <t>effects</t> of Alimta in combination with cisplatin were compared with those of cisplatin alone." and "the effects of Alimta were compared with those of docetaxel..."
    *   Contextual clues: Alimta is a medicine (cytotoxic, antimetabolite). The text discusses studies comparing Alimta with other treatments (cisplatin, docetaxel).

    *   Sense 1: outward appearance (impression). (Incorrect)
    *   Sense 2: phenomenon that follows and is caused by some previous phenomenon (consequence, outcome, result). (Possible, but general)
    *   Sense 3: a symptom caused by an illness or a drug. (Very specific to medicine/drugs)
    *   Sense 4: legal validity (force). (Incorrect)
    *   Sense 5: central meaning or theme. (Incorrect)
    *   Sense 6: artificial impression. (Incorrect)

    *   The context is medical. Alimta is a drug.
    *   "The effects of Alimta" refers to the results/outcomes/symptoms/responses produced by the drug in patients.
    *   Sense 2 is a general "result/consequence".
    *   Sense 3 is specifically "a symptom caused by an illness or a drug".
    *   In medical studies, "effects" usually refer to both the therapeutic effects (efficacy) and the side effects (symptoms). Sense 3 specifically mentions "caused by... a drug".

    *   Sense 2: "a phenomenon that follows and is caused by some previous phenomenon" (e.g., magnetic effect).
    *   Sense 3: "a symptom caused by an illness or a drug" (e.g., effect of the anesthetic).
    *   The context is comparing the results of drug treatments. While "effects" here could be seen as "outcomes" (Sense 2), the specific mention of a drug makes Sense 3 a very strong candidate. However, "symptom" in Sense 3 often implies a side effect or a specific physiological response.
    *   Wait, let's look at the examples for Sense 3: "the effects of sleep loss; the effect of the anesthetic". These are physiological responses.
    *   In the context "The effects of Alimta... were compared", it refers to the clinical outcomes/responses (efficacy and safety).
    *   Is "efficacy" a "symptom"? Not exactly. But "effect of a drug" is the classic usage for Sense 3.
    *   Let's re-evaluate Sense 2: "consequence, outcome, result". Clinical trial results are outcomes.
    *   However, in WordNet, the distinction between a general "result" (Sense 2) and a "drug effect" (Sense 3) is usually that Sense 3 is the physiological response.
    *   Looking at the context again: "The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone." This refers to the overall impact/result of the treatment.
    *   Comparing Sense 2 and Sense 3:
        *   Sense 2: general result.
        *   Sense 3: drug/illness symptom/response.
    *   Usually, in these datasets, when a drug is mentioned, Sense 3 is the intended one for "effect".

    *   Sense 3: "a symptom caused by an illness or a drug".
    *   Example: "the effect of the anesthetic".
    *   Context: "The effects of Alimta...".
    *   This fits perfectly.

    *   Sense 2: "a phenomenon that follows and is caused by some previous phenomenon".
    *   Example: "the magnetic effect was greater".
    *   While technically true, Sense 3 is more specific to the medical context provided.

    *   Target: effects
    *   Context: Drug study.
    *   Sense 3: symptom/response caused by a drug.
    *   Sense 2: general result.
    *   Sense 3 is the most precise fit for a drug's action/result in a patient.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: compare
Target surface form: compared
Context:
How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were <t>compared</t> with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past.

Candidate senses:
1. sense_key=compare%2:42:00:: | definition=be comparable | examples=This car does not compare with our line of Mercedes
2. sense_key=compare%2:31:00:: | definition=examine and note the similarities or differences of | examples=John compared his haircut to his friend's; We compared notes after we had both seen the movie
3. sense_key=compare%2:31:01:: | definition=consider or describe as similar, equal, or analogous | synonyms=liken, equate | examples=We can compare the Han dynasty to the Romans; You cannot equate success in financial matters with greed
4. sense_key=compare%2:32:00:: | definition=to form the comparative or superlative form on an adjective or adverb

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
*   Target lemma: `compare`
    *   Target surface form: `compared`
    *   Context: "The effects of Alimta in combination with cisplatin were <t>compared</t> with those of cisplatin alone." and "the effects of Alimta were compared with those of docetaxel..."
    *   Meaning: In a clinical study, the effects of one treatment (Alimta + cisplatin) were analyzed against another (cisplatin alone) to see the difference/similarity in efficacy.

    *   Sense 1: `be comparable` (e.g., "This car does not compare with our line of Mercedes"). This is about quality or status (being as good as).
    *   Sense 2: `examine and note the similarities or differences of` (e.g., "John compared his haircut to his friend's"). This is the act of analysis/comparison.
    *   Sense 3: `consider or describe as similar, equal, or analogous` (e.g., "We can compare the Han dynasty to the Romans"). This is about likening one thing to another (metaphorical or analogical).
    *   Sense 4: `to form the comparative or superlative form on an adjective or adverb`. (Grammatical sense).

    *   The context describes a scientific study.
    *   "The effects... were compared with those of..."
    *   This is a systematic examination to note differences or similarities in outcomes (efficacy, safety, etc.).
    *   This fits Sense 2 ("examine and note the similarities or differences of") perfectly.
    *   It is not Sense 1 (it's not saying Alimta *is* comparable, but that they *were compared*).
    *   It is not Sense 3 (it's not likening Alimta to docetaxel as an analogy).
    *   It is not Sense 4 (not grammatical).

    *   Sense 2 is the correct fit.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: treatment
Target surface form: treatment
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the <t>treatment</t> of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=treatment%1:04:00:: | definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) | synonyms=intervention
2. sense_key=treatment%1:04:01:: | definition=the management of someone or something | synonyms=handling | examples=the handling of prisoners; the treatment of water sewage
3. sense_key=treatment%1:10:00:: | definition=an extended communication (often interactive) dealing with some particular topic | synonyms=discussion, discourse | examples=the book contains an excellent discussion of modal logic; his treatment of the race question is badly biased
4. sense_key=treatment%1:07:00:: | definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: "treatment"
    *   Target surface form: "treatment"
    *   Context: The text discusses Alimta (pemetrexed), a cytotoxic medicine used for cancer. Specifically, it mentions "the treatment of malignant pleural mesothelioma" and "the treatment of non-small cell lung cancer."
    *   Candidate senses:
        1.  `treatment%1:04:00`: care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury). Synonyms: intervention.
        2.  `treatment%1:04:01`: the management of someone or something. Synonyms: handling. Examples: handling of prisoners, treatment of water sewage.
        3.  `treatment%1:10:00`: an extended communication dealing with some particular topic. Synonyms: discussion, discourse.
        4.  `treatment%1:07:00`: a manner of dealing with something artistically.

    *   The context is clearly medical. It talks about a "cytotoxic medicine," "cancer cells," "chemotherapy," and specific diseases ("malignant pleural mesothelioma," "non-small cell lung cancer").
    *   The phrase "For the treatment of non-small cell lung cancer" refers to the medical application of the drug Alimta to cure or manage the disease.

    *   Sense 1: "care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)" - This fits perfectly.
    *   Sense 2: "the management of someone or something" (handling) - This is too general and doesn't fit the medical context of treating a disease.
    *   Sense 3: "an extended communication" (discussion) - Not applicable.
    *   Sense 4: "a manner of dealing with something artistically" - Not applicable.

    *   The best sense is Sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cell
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small <t>cell</t> lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
2. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
3. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
4. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell
5. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
6. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
7. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: "cell"
    *   Target surface form: "cell"
    *   Context: "For the treatment of non-small <t>cell</t> lung cancer..."
    *   Surrounding context: The text discusses "cytotoxic medicine", "cancer cells", "nucleotides", "DNA and RNA", "malignant pleural mesothelioma", "chemotherapy", and "non-small cell lung cancer".

    *   Sense 1: (biology) the basic structural and functional unit of all organisms.
    *   Sense 2: small room for monk/nun.
    *   Sense 3: mobile radiotelephone.
    *   Sense 4: room for a prisoner.
    *   Sense 5: any small compartment (e.g., honeycomb).
    *   Sense 6: device delivering electric current.
    *   Sense 7: small unit of a political movement.

    *   The phrase "non-small cell lung cancer" refers to a type of cancer.
    *   Cancer is a disease of the cells (biological units).
    *   The context explicitly mentions "cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells)".
    *   Therefore, "cell" in "non-small cell lung cancer" refers to the biological unit.

    *   Sense 1 matches the biological definition.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: effect
Target surface form: effects
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the <t>effects</t> of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=effect%1:07:00:: | definition=an outward appearance | synonyms=impression | examples=he made a good impression; I wanted to create an impression of success
2. sense_key=effect%1:26:00:: | definition=a symptom caused by an illness or a drug | examples=the effects of sleep loss; the effect of the anesthetic
3. sense_key=effect%1:19:00:: | definition=a phenomenon that follows and is caused by some previous phenomenon | synonyms=consequence, outcome, result, event, issue, upshot | examples=the magnetic effect was greater when the rod was lengthwise; his decision had depressing consequences for business
4. sense_key=effect%1:07:01:: | definition=(of a law) having legal validity | synonyms=force | examples=the law is still in effect
5. sense_key=effect%1:10:00:: | definition=the central meaning or theme of a speech or literary work | synonyms=essence, burden, core, gist
6. sense_key=effect%1:09:00:: | definition=an impression (especially one that is artificial or contrived) | examples=he just did it for effect

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 3}
```

reasoning_content:
*   Target lemma: `effect`
    *   Target surface form: `effects`
    *   Context: "For the treatment of non-small cell lung cancer, the <t>effects</t> of Alimta were compared with those of docetaxel..."
    *   General context: A medical text discussing clinical studies of a drug (Alimta) and comparing its results/outcomes with other drugs.

    *   Sense 1: `effect%1:07:00::` - outward appearance/impression. (Incorrect)
    *   Sense 2: `effect%1:26:00::` - a symptom caused by an illness or a drug. (Possible, but "effects" in clinical trials usually refers to the overall outcome/efficacy, not just side effects/symptoms).
    *   Sense 3: `effect%1:19:00::` - a phenomenon that follows and is caused by some previous phenomenon (consequence, outcome, result). (Very likely: the results/outcomes of the treatment).
    *   Sense 4: `effect%1:07:01::` - legal validity. (Incorrect)
    *   Sense 5: `effect%1:10:00::` - central meaning/theme. (Incorrect)
    *   Sense 6: `effect%1:09:00::` - artificial impression. (Incorrect)

    *   The sentence says "the effects of Alimta were compared with those of docetaxel".
    *   In clinical trials, when comparing the "effects" of two drugs, researchers are looking at the *outcomes* or *results* (efficacy, survival rates, tumor shrinkage, etc.).
    *   Sense 2 specifically mentions "symptom caused by an illness or a drug". While drugs have side effects (symptoms), the primary goal of comparing two drugs in a study is to compare their therapeutic *results* (outcomes).
    *   Sense 3 is broader: "a phenomenon that follows and is caused by some previous phenomenon" (synonyms: consequence, outcome, result). This fits the context of a clinical study comparing the results of different treatments.

    *   Sense 2: "the effects of sleep loss; the effect of the anesthetic" (often refers to side effects or immediate physiological reactions).
    *   Sense 3: "the magnetic effect was greater when the rod was lengthwise; his decision had depressing consequences for business" (refers to the result/outcome of a cause).

    In the context of "the effects of Alimta were compared with those of docetaxel", the text is discussing the results of the clinical study. This aligns best with "outcome" or "result" (Sense 3).

    *Wait*, let me double-check Sense 2 again. "a symptom caused by an illness or a drug". If the text were talking about side effects, Sense 2 would be strong. But it's talking about the overall comparison of the drugs' performance in a study.

    Let's look at the previous sentence: "The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone." This reinforces that they are comparing the *results* of the treatment regimens.

    Sense 3 (outcome/result) is the most comprehensive and accurate fit for clinical trial results.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: compare
Target surface form: compared
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were <t>compared</t> with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=compare%2:42:00:: | definition=be comparable | examples=This car does not compare with our line of Mercedes
2. sense_key=compare%2:32:00:: | definition=to form the comparative or superlative form on an adjective or adverb
3. sense_key=compare%2:31:01:: | definition=consider or describe as similar, equal, or analogous | synonyms=liken, equate | examples=We can compare the Han dynasty to the Romans; You cannot equate success in financial matters with greed
4. sense_key=compare%2:31:00:: | definition=examine and note the similarities or differences of | examples=John compared his haircut to his friend's; We compared notes after we had both seen the movie

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 4}
```

reasoning_content:
*   Target lemma: `compare`
    *   Target surface form: `compared`
    *   Context: "For the treatment of non-small cell lung cancer, the effects of Alimta were <t>compared</t> with those of docetaxel..."
    *   Surrounding context: The text describes clinical studies where the effects of one drug (Alimta) are evaluated against another (docetaxel, gemcitabine) to see which is more effective or how they differ.

    *   Sense 1: `be comparable` (e.g., "This car does not compare with our line of Mercedes"). This is about quality or status.
    *   Sense 2: `to form the comparative or superlative form on an adjective or adverb`. (Grammatical sense).
    *   Sense 3: `consider or describe as similar, equal, or analogous` (synonyms: liken, equate). This is about making an analogy or claiming two things are essentially the same.
    *   Sense 4: `examine and note the similarities or differences of` (e.g., "John compared his haircut to his friend's"). This is about analysis, evaluation, and contrasting.

    *   The context is a medical study. In clinical trials, "comparing" the effects of two drugs means examining the data to see the differences (efficacy, safety, etc.) between the treatment group and the control group.
    *   This fits Sense 4 ("examine and note the similarities or differences of") perfectly.
    *   It does not fit Sense 1 (it's not saying Alimta is "comparable" in quality, but that it was *subjected to a comparison*).
    *   It does not fit Sense 2 (not grammatical).
    *   It does not fit Sense 3 (it's not saying Alimta *is* like docetaxel, but that they were *compared* to see how they differ).

    *   Sense 4 is the correct choice.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer <t>medicine</t>) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine
4. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
*   Target lemma: `medicine`
    *   Target surface form: `medicine`
    *   Context: "...the effects of Alimta were compared with those of docetaxel (another anticancer <t>medicine</t>) in one study..."
    *   Candidate senses:
        1.  `medicine%1:04:00::`: The learned profession (medical school, practice of medicine).
        2.  `medicine%1:06:00::`: Something that treats or prevents or alleviates symptoms (medication, medicinal drug).
        3.  `medicine%1:04:02::`: Punishment for one's actions (take your medicine).
        4.  `medicine%1:09:00::`: Branches of medical science (nonsurgical techniques).

    *   The sentence refers to "docetaxel (another anticancer medicine)".
    *   Docetaxel is a drug used to treat cancer.
    *   The context discusses "active substance", "cytotoxic medicine", "chemotherapy", and "anticancer medicine".
    *   This clearly refers to a medicinal drug or medication.

    *   Sense 1: Profession (Incorrect)
    *   Sense 2: Medication/drug (Correct)
    *   Sense 3: Punishment (Incorrect)
    *   Sense 4: Medical science branch (Incorrect)

    *   The best fit is sense 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: study
Target surface form: study
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one <t>study</t> involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=study%1:10:00:: | definition=a written document describing the findings of some individual or group | synonyms=report, written report | examples=this accords with the recent study by Hill and Dale
2. sense_key=study%1:09:03:: | definition=applying the mind to learning and understanding a subject (especially by reading) | synonyms=work | examples=mastering a second language requires a lot of work; no schools offer graduate study in interior design
3. sense_key=study%1:10:01:: | definition=a composition intended to develop one aspect of the performer's technique | examples=a study in spiccato bowing
4. sense_key=study%1:09:02:: | definition=a branch of knowledge | synonyms=discipline, subject, subject area, subject field, field, field of study | examples=in what discipline is his doctorate?; teachers should be well trained in their subject
5. sense_key=study%1:09:01:: | definition=attentive consideration and meditation | synonyms=cogitation | examples=after much cogitation he rejected the offer
6. sense_key=study%1:06:01:: | definition=preliminary drawing for later elaboration | synonyms=sketch | examples=he made several studies before starting to paint
7. sense_key=study%1:18:00:: | definition=someone who memorizes quickly and easily (as the lines for a part in a play) | examples=he is a quick study
8. sense_key=study%1:09:04:: | definition=a state of deep mental absorption | examples=she is in a deep study
9. sense_key=study%1:06:00:: | definition=a room used for reading and writing and studying | examples=he knocked lightly on the closed door of the study
10. sense_key=study%1:04:00:: | definition=a detailed critical inspection | synonyms=survey

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: `study`
    *   Target surface form: `study`
    *   Context: "...the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one <t>study</t> involving 571 patients..."
    *   Candidate senses:
        1.  `study%1:10:00::`: a written document describing the findings of some individual or group (report, written report).
        2.  `study%1:09:03::`: applying the mind to learning and understanding a subject (work).
        3.  `study%1:10:01::`: a composition intended to develop one aspect of the performer's technique.
        4.  `study%1:09:02::`: a branch of knowledge (discipline, subject).
        5.  `study%1:09:01::`: attentive consideration and meditation (cogitation).
        6.  `study%1:06:01::`: preliminary drawing for later elaboration (sketch).
        7.  `study%1:18:00::`: someone who memorizes quickly and easily.
        8.  `study%1:09:04::`: a state of deep mental absorption.
        9.  `study%1:06:00::`: a room used for reading and writing and studying.
        10. `study%1:04:00::`: a detailed critical inspection (survey).

    *   The context describes clinical trials for a medicine (Alimta).
    *   "one study involving 571 patients" refers to a clinical trial or a research project designed to test the efficacy of a drug.
    *   In medical contexts, a "study" is typically the research process and the resulting report/document that describes the findings.

    *   Sense 1: "a written document describing the findings of some individual or group" (report, written report). This fits well, as clinical trials are documented as studies.
    *   Sense 10: "a detailed critical inspection" (survey). This is more about inspection than a controlled clinical trial.
    *   Sense 2, 4, 5, 8: These relate to learning, academic disciplines, or mental states. Not applicable.
    *   Sense 3, 6: These relate to art/music. Not applicable.
    *   Sense 7: Relates to a person. Not applicable.
    *   Sense 9: Relates to a room. Not applicable.

    *   In the phrase "in one study involving 571 patients", "study" refers to the clinical trial.
    *   While "study" can mean the *process* of investigation, in WordNet's noun senses provided, Sense 1 ("a written document describing the findings") is the closest match for a scientific/medical study (which is often used interchangeably with the report of that study).
    *   Let's double-check Sense 10 ("detailed critical inspection"). A clinical trial is a systematic investigation, but "inspection" usually implies looking at something existing rather than conducting an experiment.
    *   Sense 1 is the standard mapping for "scientific study" or "clinical study" when referring to the entity (the trial/report).

    *   Context: "the effects of Alimta were compared... in one study involving 571 patients"
    *   Sense 1: "a written document describing the findings of some individual or group"
    *   Wait, is there a better sense for "clinical trial"?
    *   Looking at the options again:
        1. written document/report
        10. detailed critical inspection/survey
    *   In many WordNet-based WSD tasks, "study" in the sense of a scientific investigation is mapped to the "report" or "written document" sense (Sense 1) because the "study" is the published result of the investigation.

    *   Sense 1: report, written report.
    *   Sense 10: survey, detailed critical inspection.
    *   A clinical trial is more like a systematic investigation than a "critical inspection" (which sounds like an audit or a review). It is most commonly represented as a "study" (the report of the research).

    *   Sense 1: "this accords with the recent study by Hill and Dale" -> This matches the usage "in one study involving 571 patients".

    *   Sense 1 is the best fit.