[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: see
Target surface form: see
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=see%2:41:12:: | definition=go to see for a social visit | examples=I went to see my friend Mary the other day
2. sense_key=see%2:39:02:: | definition=perceive or be contemporaneous with | synonyms=witness, find | examples=We found Republicans winning the offices; You'll see a lot of cheating in this school
3. sense_key=see%2:38:03:: | definition=accompany or escort | synonyms=escort | examples=I'll see you to the door
4. sense_key=see%2:39:03:: | definition=see or watch | synonyms=watch, view, catch, take in | examples=view a show on television; This program will be seen all over the world
5. sense_key=see%2:39:12:: | definition=go or live through | synonyms=experience, go through | examples=We had many trials to go through; he saw action in Viet Nam
6. sense_key=see%2:31:00:: | definition=deem to be | synonyms=consider, reckon, view, regard | examples=She views this quite differently from me; I consider her to be shallow
7. sense_key=see%2:35:09:: | definition=receive as a specified guest | examples=the doctor will see you now; The minister doesn't see anybody before noon
8. sense_key=see%2:39:05:: | definition=see and understand, have a good eye | examples=The artist must first learn to see
9. sense_key=see%2:41:14:: | definition=take charge of or deal with | synonyms=attend, take care, look | examples=Could you see about lunch?; I must attend to this matter
10. sense_key=see%2:39:11:: | definition=observe as if with an eye | examples=The camera saw the burglary and recorded it
11. sense_key=see%2:33:00:: | definition=match or meet | examples=I saw the bet of one of my fellow players
12. sense_key=see%2:41:00:: | definition=date regularly; have a steady relationship with | synonyms=go steady, go out, date | examples=Did you know that she is seeing an older man?; He is dating his former wife again!
13. sense_key=see%2:31:01:: | definition=perceive (an idea or situation) mentally | synonyms=understand, realize, realise | examples=Now I see!; I just can't see your point
14. sense_key=see%2:38:00:: | definition=come together | synonyms=meet, run into, encounter, run across, come across | examples=I'll probably see you at the meeting; How nice to see you again!
15. sense_key=see%2:39:13:: | definition=observe, check out, and look over carefully or inspect | synonyms=examine | examples=The customs agent examined the baggage; I must see your passport before you can enter the country
16. sense_key=see%2:31:02:: | definition=get to know or become aware of, usually accidentally | synonyms=learn, hear, get word, get wind, pick up, find out | examples=I learned that she has two grown-up children; I see that you have been promoted
17. sense_key=see%2:31:03:: | definition=be careful or certain to do something; make certain of something | synonyms=check, insure, see to it, ensure, control, ascertain | examples=He verified that the valves were closed; See that the curtains are closed
18. sense_key=see%2:39:00:: | definition=perceive by sight or have the power to perceive by sight | examples=You have to be a good observer to see all the details; Can you see the bird in that tree?
19. sense_key=see%2:36:00:: | definition=imagine; conceive of; see in one's mind | synonyms=visualize, visualise, envision, project, fancy, figure | examples=I can't see him on horseback!; I can see what will happen
20. sense_key=see%2:41:11:: | definition=go to see for professional or business reasons | examples=You should see a lawyer; We had to see a psychiatrist
21. sense_key=see%2:41:10:: | definition=go to see a place, as for entertainment | synonyms=visit | examples=We went to see the Eiffel Tower in the morning
22. sense_key=see%2:31:13:: | definition=make sense of; assign a meaning to | synonyms=interpret, construe | examples=What message do you see in this letter?; How do you interpret his behavior?
23. sense_key=see%2:31:08:: | definition=deliberate or decide | examples=See whether you can come tomorrow; let's see--which movie should we see tonight?
24. sense_key=see%2:32:00:: | definition=find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, find out, ascertain, watch, learn | examples=I want to see whether she speaks French; See whether it works

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 15}
```

content:
```json
{"sense_index": 15}
```

reasoning_content:
*   Target lemma: `see`
    *   Target surface form: `see`
    *   Context: "For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR)."
    *   Meaning: In this context, "see" is used as an imperative directing the reader to refer to or consult another document for more information.

    *   1: social visit (No)
    *   2: perceive/contemporaneous (No)
    *   3: accompany/escort (No)
    *   4: watch/view (No)
    *   5: experience (No)
    *   6: deem to be (No)
    *   7: receive as guest (No)
    *   8: see and understand (No)
    *   9: take charge of/deal with (No)
    *   10: observe as if with an eye (No)
    *   11: match or meet (No)
    *   12: date regularly (No)
    *   13: perceive mentally/understand (No)
    *   14: come together/meet (No)
    *   15: observe, check out, look over carefully or inspect (examine) (Possible, but usually implies a physical inspection)
    *   16: get to know/become aware of (No)
    *   17: be careful/certain to do something (No)
    *   18: perceive by sight (No)
    *   19: imagine/conceive (No)
    *   20: professional/business reasons (No)
    *   21: visit a place (No)
    *   22: make sense of/interpret (No)
    *   23: deliberate or decide (No)
    *   24: find out, learn, or determine with certainty, usually by making an inquiry or other effort (synonyms: determine, check, find out, ascertain, watch, learn) (Possible)

    *   The phrase "For more information, see [document]" is a standard way to tell someone to refer to or consult a source.
    *   Looking at the candidate senses again, none of them explicitly say "refer to a text."
    *   Let's re-examine Sense 15: "observe, check out, and look over carefully or inspect | synonyms=examine".
    *   Let's re-examine Sense 24: "find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, find out, ascertain, watch, learn".
    *   Let's re-examine Sense 18: "perceive by sight". (Too literal).
    *   Let's re-examine Sense 4: "see or watch". (Too literal).

    Wait, let me look closer at the senses provided. Is there a "refer to" sense?
    Looking through the list again:
    1. social visit
    2. perceive/contemporaneous
    3. escort
    4. watch/view
    5. experience
    6. deem
    7. receive guest
    8. see and understand
    9. take charge of
    10. observe as if with an eye
    11. match
    12. date
    13. understand
    14. meet
    15. examine (observe, check out, and look over carefully)
    16. learn/hear
    17. ensure
    18. perceive by sight
    19. imagine
    20. professional visit
    21. visit place
    22. interpret
    23. deliberate
    24. find out/determine

    In many WordNet-based datasets, "see [document]" is often mapped to a sense like "examine" or "look at" or "refer to".
    Sense 15: "observe, check out, and look over carefully or inspect | synonyms=examine".
    Sense 24: "find out, learn, or determine with certainty... usually by making an inquiry".

    Comparing "see the Summary of Product Characteristics" with "examine the Summary of Product Characteristics" vs "find out the Summary of Product Characteristics". "Examine" or "look at" fits better.

    Let's check if there's any other sense.
    Sense 18 is "perceive by sight". While you do use your eyes to read, "see" in "see page 10" is more about referring to it.

    Wait, let me look at Sense 15 again: "observe, check out, and look over carefully or inspect".
    And Sense 4: "see or watch".
    And Sense 18: "perceive by sight".

    Actually, in many contexts of "see [reference]", it's treated as "look at" or "examine".
    Let's look at Sense 15's example: "I must see your passport before you can enter the country". This is very similar to "see the Summary of Product Characteristics". You are being asked to look at/examine a document.

    Let's double-check Sense 24: "I want to see whether she speaks French". This is "find out". "See the Summary" isn't "find out the Summary", it's "refer to the Summary to find out more information".

    Is there any other sense?
    Sense 16: "get to know or become aware of... I see that you have been promoted". (No).

    Let's re-evaluate Sense 15: "observe, check out, and look over carefully or inspect | synonyms=examine".
    If you "see the Summary of Product Characteristics", you are checking it out or examining it for information.

    Let's look at Sense 18 again: "perceive by sight". This is the most basic meaning. Sometimes "see" in references is just mapped to the basic "look at" sense. But Sense 15 is more specific to "checking out" a document.

    Wait, let me search for "see" in WordNet for the meaning "refer to".
    In some versions of WordNet, "see" (refer to) is a separate sense. But it's not explicitly listed here as "refer to".
    Let's look at the options again.
    Sense 15: "observe, check out, and look over carefully or inspect | synonyms=examine".
    Sense 18: "perceive by sight".

    If I have to choose the *best* one from this list:
    "For more information, see the Summary..."
    This means "refer to" or "consult".
    "Consult" is similar to "examine" (Sense 15) or "find out" (Sense 24).
    However, "examine" (Sense 15) fits the action of looking at a document better than "find out" (Sense 24).

    Let's re-read Sense 15: "observe, check out, and look over carefully or inspect".
    Example: "I must see your passport".
    This is very close to "see the Summary of Product Characteristics".

    Let's check Sense 4: "see or watch | synonyms=watch, view, catch, take in".
    Example: "view a show on television". (Less likely).

    Let's check Sense 18: "perceive by sight".
    Example: "Can you see the bird in that tree?". (Too simple).

    Sense 15 seems the most plausible among the choices for "refer to a document".

    Wait, let me think about Sense 24 again: "find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, find out, ascertain, watch, learn".
    "For more information, see [document]" -> "For more information, [find out/check] [document]".
    Actually, "check the Summary" is a very common way to say "see the Summary".

    Let's compare:
    Sense 15: "examine the Summary"
    Sense 24: "check the Summary"

    In the context of "For more information, see...", the goal is to *find out* more information. The action is to *check* the document.
    Sense 24 synonyms: "determine, check, find out, ascertain, watch, learn".
    Sense 15 synonyms: "examine".

    "Check" (Sense 24) often fits "see" when it means "verify" or "find out".
    "Examine" (Sense 15) often fits "see" when it means "inspect".

    "See the Summary of Product Characteristics" is more about referring to it to find information than inspecting it for flaws.

    Let's look at Sense 24's example: "See whether it works".
    This is "find out whether it works".
    "See the Summary" is not "find out the Summary".

    Let's look at Sense 15's example: "I must see your passport".
    This is "I must examine/look at your passport".
    "See the Summary" is "look at/examine the Summary".

    This feels closer.

    Wait, let me search for this specific WordNet sense mapping for "see" meaning "refer to".
    Often, "see" in the sense of "refer to" is mapped to "perceive by sight" (Sense 18) or "examine" (Sense 15).
    But let's look at the options again. Is there anything else?
    Sense 16: "get to know or become aware of... I see that you have been promoted".
    Sense 24: "find out, learn, or determine with certainty... See whether it works".

    Let's try to see if "see" as "refer to" is a common sense in WordNet.
    In some WordNet versions, "see" (refer to) is listed as "consult".
    If "consult" isn't here, "examine" (15) or "perceive by sight" (18) are the closest.
    Between "examine" and "perceive by sight", "examine" (15) is more active and fits the context of looking for information in a document.

    Let's double-check Sense 15 again: "observe, check out, and look over carefully or inspect".
    "Check out" is a very good synonym for "see" in "see the Summary".

    Let's double-check Sense 18: "perceive by sight".
    This is very general.

    Let's double-check Sense 4: "see or watch".
    This is more for entertainment or observing an event.

    Final check of Sense 15: "observe, check out, and look over carefully or inspect | synonyms=examine | examples=The customs agent examined the baggage; I must see your passport before you can enter the country".
    This matches the usage of "see" when referring to a document for verification or information.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: product
Target surface form: Product
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=product%1:06:01:: | definition=commodities offered for sale | synonyms=merchandise, ware | examples=good business depends on having good merchandise; that store offers a variety of products
2. sense_key=product%1:27:00:: | definition=a chemical substance formed as a result of a chemical reaction | examples=a product of lime and nitric acid
3. sense_key=product%1:09:00:: | definition=a quantity obtained by multiplication | synonyms=mathematical product | examples=the product of 2 and 3 is 6
4. sense_key=product%1:14:00:: | definition=the set of elements common to two or more sets | synonyms=intersection, Cartesian product | examples=the set of red hats is the intersection of the set of hats and the set of red things
5. sense_key=product%1:06:00:: | definition=an artifact that has been created by someone or some process | synonyms=production | examples=they improve their product every year; they export most of their agricultural production
6. sense_key=product%1:19:00:: | definition=a consequence of someone's efforts or of a particular set of circumstances | examples=skill is the product of hours of practice; his reaction was the product of hunger and fatigue

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

finish_reason: stop

content:
```json
{"sense_index": 1}
```

role: assistant

reasoning_content:
*   Target lemma: "product"
    *   Target surface form: "Product"
    *   Context: "For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR)."
    *   Surrounding context: The text discusses a medication called Alimta, its administration, side effects, and contraindications. "EPAR" likely stands for European Public Assessment Report. "Summary of Product Characteristics" (SmPC) is a standard regulatory document for medicines.

    *   Sense 1: commodities offered for sale (merchandise, ware).
    *   Sense 2: a chemical substance formed as a result of a chemical reaction.
    *   Sense 3: a quantity obtained by multiplication (mathematical product).
    *   Sense 4: the set of elements common to two or more sets (intersection, Cartesian product).
    *   Sense 5: an artifact that has been created by someone or some process (production).
    *   Sense 6: a consequence of someone's efforts or of a particular set of circumstances.

    *   The phrase "Summary of Product Characteristics" refers to the pharmaceutical product (the drug Alimta).
    *   Is it a "commodity offered for sale" (Sense 1)? Yes, medicines are sold.
    *   Is it a "chemical substance formed as a result of a chemical reaction" (Sense 2)? While the drug is a chemical substance, the "Product" in "Summary of Product Characteristics" refers to the commercial drug product as a whole (the branded medicine), not just the chemical reaction result.
    *   Is it an "artifact that has been created by someone or some process" (Sense 5)? A drug is an artifact/production.
    *   Comparing Sense 1 and Sense 5: "Summary of Product Characteristics" is a regulatory term. In this context, "product" refers to the commercialized medicine. Sense 1 (commodities offered for sale) fits well for a commercial drug. Sense 5 (artifact created by a process) is more general.

    *   In pharmaceutical regulatory contexts, "Product" refers to the medicinal product.
    *   Sense 1: "commodities offered for sale" (merchandise, ware).
    *   Sense 5: "an artifact that has been created by someone or some process" (production).
    *   Looking at the examples for Sense 1: "that store offers a variety of products".
    *   Looking at the examples for Sense 5: "they improve their product every year".
    *   Actually, in many WSD datasets (like SemCor), "product" in the sense of a commercial item is often mapped to the "commodity" sense.

    *   Sense 1: commodities offered for sale.
    *   Sense 5: an artifact that has been created by someone or some process.
    *   A medicinal product is a commodity sold on the market. The "Summary of Product Characteristics" describes the commercial drug.

    *   Sense 1: merchandise, ware.
    *   Sense 5: production.
    *   "Product Characteristics" usually refers to the properties of the commercial item.

    *   Sense 1 is the most specific for a commercial item like a drug.

    *   Wait, let me re-read Sense 5: "an artifact that has been created by someone or some process".
    *   Let me re-read Sense 1: "commodities offered for sale".
    *   A drug is both. However, "Summary of Product Characteristics" is a formal term for the commercial drug product. Sense 1 is generally used for commercial goods.

    *   Sense 1: product%1:06:01:: (commodities offered for sale)
    *   Sense 5: product%1:06:00:: (an artifact that has been created by someone or some process)
    *   In WordNet, 06:01 is a hyponym of 06:00. 06:00 is the general "artifact", and 06:01 is the specific "commodity". Since a medicine is a commercial commodity, 06:01 is the more precise sense.

    *   Context: "Summary of Product Characteristics"
    *   Sense 1: commodities offered for sale.
    *   This fits perfectly.

currency: USD

source: unavailable


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: part
Target surface form: part
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=part%1:04:03:: | definition=the part played by a person in bringing about a result | synonyms=contribution, share | examples=I am proud of my contribution in advancing the project; they all did their share of the work
2. sense_key=part%1:08:01:: | definition=a line of scalp that can be seen when sections of hair are combed in opposite directions | synonyms=parting | examples=his part was right in the middle
3. sense_key=part%1:09:00:: | definition=one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division | examples=the written part of the exam; the finance section of the company
4. sense_key=part%1:21:00:: | definition=assets belonging to or due to or contributed by an individual person or group | synonyms=share, portion, percentage | examples=he wanted his share in cash
5. sense_key=part%1:09:02:: | definition=that which concerns a person with regard to a particular role or situation | examples=it requires vigilance on our part; they resisted every effort on his part
6. sense_key=part%1:10:00:: | definition=the melody carried by a particular voice or instrument in polyphonic music | synonyms=voice | examples=he tried to sing the tenor part
7. sense_key=part%1:06:00:: | definition=something less than the whole of a human artifact | synonyms=portion | examples=the rear part of the house; glue the two parts together
8. sense_key=part%1:24:00:: | definition=something determined in relation to something that includes it | synonyms=portion, component part, component, constituent | examples=he wanted to feel a part of something bigger than himself; I read a portion of the manuscript
9. sense_key=part%1:15:00:: | definition=the extended spatial location of something | synonyms=region | examples=the farming regions of France; religions in all parts of the world
10. sense_key=part%1:17:00:: | definition=a portion of a natural object | synonyms=piece | examples=they analyzed the river into three parts; he needed a piece of granite
11. sense_key=part%1:04:01:: | definition=the actions and activities assigned to or required or expected of a person or group | synonyms=function, office, role | examples=the function of a teacher; the government must do its part
12. sense_key=part%1:09:01:: | definition=an actor's portrayal of someone in a play | synonyms=character, role, theatrical role, persona | examples=she played the part of Desdemona

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 3}
```

content:
```json
{"sense_index": 3}
```

reasoning_content:
*   Target lemma: "part"
    *   Target surface form: "part"
    *   Context: "For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR)."
    *   Meaning: The "Summary of Product Characteristics" is a section or a component of the "EPAR" (European Public Assessment Report).

    *   1: contribution/share (bringing about a result) - No.
    *   2: hair parting - No.
    *   3: one of the portions into which something is regarded as divided and which together constitute a whole (section, division) - Yes, a document section.
    *   4: assets/share - No.
    *   5: concern/role (vigilance on our part) - No.
    *   6: musical melody/voice - No.
    *   7: something less than the whole of a human artifact (portion) - Possible, but "section" (sense 3) is more specific for documents.
    *   8: something determined in relation to something that includes it (component part) - Possible, but sense 3 fits "section of a document" better.
    *   9: spatial location/region - No.
    *   10: portion of a natural object - No.
    *   11: actions/activities/role - No.
    *   12: actor's role - No.

    *   Sense 3: "one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division | examples=the written part of the exam; the finance section of the company"
    *   Sense 7: "something less than the whole of a human artifact | synonyms=portion | examples=the rear part of the house; glue the two parts together"
    *   Sense 8: "something determined in relation to something that includes it | synonyms=portion, component part, component, constituent | examples=he wanted to feel a part of something bigger than himself; I read a portion of the manuscript"

    The "Summary of Product Characteristics" is a specific *section* or *division* of the EPAR document. Sense 3 explicitly lists "section" and "division" as synonyms and provides an example ("the written part of the exam") that mirrors a part of a larger structured document/assessment.

    *   Sense 3: section, division. (Fits perfectly for a document part).
    *   Sense 7: physical part of an artifact. (Less fitting for a document section).
    *   Sense 8: component part. (More general, often used for membership or abstract components).

    Sense 3 is the most precise fit for a section of a report.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
2. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
3. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
4. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
5. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
6. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
7. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
8. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
12. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession
13. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
14. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 14}
```

content:
```json
{"sense_index": 14}
```

reasoning_content:
*   Target word: "active"
    *   Context: "The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine..."
    *   Meaning: In the context of medicine/pharmacology, an "active substance" (or active ingredient) is the component of a drug that produces the intended biological effect.

    *   1: energetic activity (toddler) - No.
    *   2: in operation/alive (hope) - No.
    *   3: erupting (volcanoes) - No.
    *   4: disposed to take action (director) - No.
    *   5: military operations (combat-ready) - No.
    *   6: full of activity (seaport) - No.
    *   7: taking part in an activity (member) - No.
    *   8: grammar (verbs) - No.
    *   9: sunspots (sun) - No.
    *   10: grammar (subject as actor) - No.
    *   11: becoming more severe (tuberculosis) - No.
    *   12: full-time work (profession) - No.
    *   13: capable of erupting (volcanoes) - No.
    *   14: exerting influence or producing a change or effect (example: "an active ingredient") - Yes.

    *   The context "active substance in Alimta" is synonymous with "active ingredient".
    *   Sense 14 specifically lists "an active ingredient" as an example and defines it as "exerting influence or producing a change or effect". This fits perfectly.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: substance
Target surface form: substance
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=substance%1:03:01:: | definition=a particular kind or species of matter with uniform properties | examples=shigella is one of the most toxic substances known to man
2. sense_key=substance%1:09:01:: | definition=the choicest or most essential or most vital part of some idea or experience | synonyms=kernel, core, center, centre, essence, gist | examples=the gist of the prosecutor's argument; the heart and soul of the Republican Party
3. sense_key=substance%1:03:00:: | definition=the real physical matter of which a person or thing consists | examples=DNA is the substance of our genes
4. sense_key=substance%1:21:00:: | definition=considerable capital (wealth or income) | synonyms=means | examples=he is a man of means
5. sense_key=substance%1:09:00:: | definition=the idea that is intended | synonyms=meaning | examples=What is the meaning of this proverb?
6. sense_key=substance%1:10:00:: | definition=what a communication that is about something is about | synonyms=message, content, subject matter
7. sense_key=substance%1:27:00:: | definition=material of a particular kind or constitution | examples=the immune response recognizes invading substances

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: `substance`
    *   Target surface form: `substance`
    *   Context: "The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine..."
    *   Candidate senses:
        1.  `substance%1:03:01::`: a particular kind or species of matter with uniform properties (e.g., shigella is one of the most toxic substances).
        2.  `substance%1:09:01::`: the choicest or most essential or most vital part of some idea or experience (kernel, core, essence).
        3.  `substance%1:03:00::`: the real physical matter of which a person or thing consists (e.g., DNA is the substance of our genes).
        4.  `substance%1:21:00::`: considerable capital (wealth or income).
        5.  `substance%1:09:00::`: the idea that is intended (meaning).
        6.  `substance%1:10:00::`: what a communication that is about something is about (message, content).
        7.  `substance%1:27:00::`: material of a particular kind or constitution (e.g., the immune response recognizes invading substances).

    *   The sentence is: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine..."
    *   "Alimta" is a drug.
    *   "Pemetrexed" is the specific chemical/drug component that performs the action.
    *   "Active substance" is a common pharmaceutical term referring to the active pharmaceutical ingredient (API).

    *   Sense 1: "a particular kind or species of matter with uniform properties". This fits well. Pemetrexed is a specific chemical substance.
    *   Sense 2: "choicest or most essential part of some idea". (Incorrect - not an idea).
    *   Sense 3: "the real physical matter of which a person or thing consists". (Incorrect - Alimta consists of pemetrexed and other excipients, but "active substance" refers to the specific chemical species).
    *   Sense 4: "considerable capital". (Incorrect).
    *   Sense 5: "the idea that is intended". (Incorrect).
    *   Sense 6: "what a communication... is about". (Incorrect).
    *   Sense 7: "material of a particular kind or constitution". (Similar to Sense 1, but Sense 1's "particular kind or species of matter with uniform properties" is a more precise fit for a chemical compound like pemetrexed).

    *   Sense 1: "a particular kind or species of matter with uniform properties" (Example: "shigella is one of the most toxic substances known to man").
    *   Sense 7: "material of a particular kind or constitution" (Example: "the immune response recognizes invading substances").
    *   In pharmaceutical contexts, "active substance" refers to the specific chemical entity (the species of matter). Sense 1 is the standard definition for a chemical substance.

    *   Sense 1 is the most accurate description of a chemical compound/API.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine
2. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
3. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
4. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 3}
```

reasoning_content:
*   Target lemma: `medicine`
    *   Target surface form: `medicine`
    *   Context: "...The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites."
    *   Candidate senses:
        1.  `medicine%1:04:02::`: punishment for one's actions (e.g., "take your medicine").
        2.  `medicine%1:09:00::`: branches of medical science (nonsurgical techniques).
        3.  `medicine%1:06:00::`: something that treats or prevents or alleviates the symptoms of disease (medication, medicinal drug).
        4.  `medicine%1:04:00::`: the learned profession (medical school, practice of medicine).

    *   The context describes "Alimta" and its active substance "pemetrexed" as a "cytotoxic medicine".
    *   It further explains it as "a medicine that kills cells that are dividing, such as cancer cells".
    *   This clearly refers to a drug or medication used for treatment.

    *   Sense 1: Punishment (Incorrect)
    *   Sense 2: Medical science branch (Incorrect)
    *   Sense 3: Medication/medicinal drug (Correct)
    *   Sense 4: Medical profession (Incorrect)

    *   The target word "medicine" in "cytotoxic medicine" refers to a medicinal drug. This matches sense 3.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

content:
```json
{"sense_index": 2}
```

reasoning_content:
*   Target lemma: "medicine"
    *   Target surface form: "medicine"
    *   Context: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells)..."
    *   Other occurrences in context: "an anti-emetic medicine (to prevent vomiting)"

    *   Sense 1: punishment for one's actions (e.g., "take your medicine").
    *   Sense 2: something that treats or prevents or alleviates the symptoms of disease (synonyms: medication, medicament, medicinal drug).
    *   Sense 3: the learned profession mastered by graduate training in a medical school (e.g., "studied medicine").
    *   Sense 4: branches of medical science dealing with nonsurgical techniques.

    *   The context refers to "Alimta", "pemetrexed", "anti-emetic medicine", and "cytotoxic medicine".
    *   These are all drugs/medications used to treat cancer or prevent side effects of cancer treatment.
    *   This aligns perfectly with Sense 2: "something that treats or prevents or alleviates the symptoms of disease".

    *   Sense 1: Not a punishment.
    *   Sense 3: Not a profession/study.
    *   Sense 4: Not a branch of medical science.
    *   Sense 2: Correct.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: kill
Target surface form: kills
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=kill%2:35:02:: | definition=deprive of life | examples=AIDS has killed thousands in Africa
2. sense_key=kill%2:30:03:: | definition=cause to cease operating | examples=kill the engine
3. sense_key=kill%2:42:00:: | definition=be fatal | examples=cigarettes kill; drunken driving kills
4. sense_key=kill%2:35:00:: | definition=cause to die; put to death, usually intentionally or knowingly | examples=This man killed several people when he tried to rob a bank; The farmer killed a pig for the holidays
5. sense_key=kill%2:30:02:: | definition=destroy a vitally essential quality of or in | examples=Eating artichokes kills the taste of all other foods
6. sense_key=kill%2:30:04:: | definition=tire out completely | examples=The daily stress of her work is killing her
7. sense_key=kill%2:30:00:: | definition=mark for deletion, rub off, or erase | synonyms=obliterate, wipe out | examples=kill these lines in the President's speech
8. sense_key=kill%2:39:00:: | definition=be the source of great pain for | examples=These new shoes are killing me!
9. sense_key=kill%2:30:08:: | definition=end or extinguish by forceful means | synonyms=stamp out | examples=Stamp out poverty!
10. sense_key=kill%2:35:05:: | definition=hit with great force | examples=He killed the ball
11. sense_key=kill%2:35:01:: | definition=cause the death of, without intention | examples=She was killed in the collision of three cars
12. sense_key=kill%2:41:01:: | definition=thwart the passage of | synonyms=shoot down, defeat, vote down, vote out | examples=kill a motion; he shot down the student's proposal
13. sense_key=kill%2:35:06:: | definition=hit with so much force as to make a return impossible, in racket games | examples=She killed the ball
14. sense_key=kill%2:37:00:: | definition=overwhelm with hilarity, pleasure, or admiration | examples=The comedian was so funny, he was killing me!
15. sense_key=kill%2:34:00:: | definition=drink down entirely | synonyms=toss off, pop, bolt down, belt down, pour down, down | examples=He downed three martinis before dinner; She killed a bottle of brandy that night

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: `kill`
    *   Target surface form: `kills`
    *   Context: "...a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells)..."
    *   Candidate senses:
        1.  `deprive of life` (e.g., AIDS has killed thousands)
        2.  `cause to cease operating` (e.g., kill the engine)
        3.  `be fatal` (e.g., cigarettes kill)
        4.  `cause to die; put to death, usually intentionally or knowingly` (e.g., man killed several people)
        5.  `destroy a vitally essential quality of or in` (e.g., artichokes kill the taste)
        6.  `tire out completely` (e.g., stress is killing her)
        7.  `mark for deletion, rub off, or erase` (e.g., kill these lines)
        8.  `be the source of great pain for` (e.g., shoes are killing me)
        9.  `end or extinguish by forceful means` (e.g., stamp out poverty)
        10. `hit with great force` (e.g., killed the ball)
        11. `cause the death of, without intention` (e.g., killed in collision)
        12. `thwart the passage of` (e.g., kill a motion)
        13. `hit with so much force as to make a return impossible` (racket games)
        14. `overwhelm with hilarity, pleasure, or admiration` (e.g., comedian was killing me)
        15. `drink down entirely` (e.g., killed a bottle of brandy)

    *   The context is medical/biological: "a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells)".
    *   "Cytotoxic" literally means "toxic to cells".
    *   The action is the destruction/death of cells.

    *   Sense 1: `deprive of life`. This is a general definition of killing.
    *   Sense 4: `cause to die; put to death, usually intentionally or knowingly`. This often refers to organisms (people, animals).
    *   Sense 3: `be fatal`. This describes the property of the agent (e.g., "cigarettes kill").
    *   Sense 11: `cause the death of, without intention`. Not applicable here.

    *   Sense 1 (`deprive of life`) is very broad.
    *   Sense 4 (`cause to die; put to death`) is also common for intentional killing.
    *   In biological contexts, "killing cells" means causing them to die.
    *   Let's look at Sense 1 again: "deprive of life". Cells are living units.
    *   Let's look at Sense 4 again: "cause to die; put to death, usually intentionally or knowingly". The medicine is designed to cause the cells to die.

    *Wait*, let's re-evaluate Sense 1 vs Sense 4.
    Sense 1: `deprive of life` (Example: AIDS has killed thousands in Africa).
    Sense 4: `cause to die; put to death, usually intentionally or knowingly` (Example: This man killed several people...).

    Actually, in many WordNet-based datasets, "killing cells" or "killing bacteria" is often mapped to the most basic sense of causing death.

    Let's check if there's a better fit.
    Sense 3: `be fatal`. "Cigarettes kill". This is an intransitive use (or a general property). In the sentence "a medicine that kills cells", "kills" is transitive.

    Comparing Sense 1 and Sense 4:
    Sense 1: `deprive of life`
    Sense 4: `cause to die; put to death, usually intentionally or knowingly`

    Usually, "deprive of life" (Sense 1) is the most general sense of causing death. Sense 4 adds the nuance of "intentionally or knowingly," which applies to the *designer* of the medicine, but the medicine itself is the agent.

    Let's look at the examples again.
    Sense 1: "AIDS has killed thousands in Africa" (Disease killing people).
    Sense 4: "This man killed several people" (Person killing people).

    The medicine killing cells is more similar to a disease killing people (Sense 1) than a person killing people (Sense 4).

    *   Sense 1: `deprive of life`
    *   Sense 4: `cause to die; put to death, usually intentionally or knowingly`

    In the context of "cytotoxic medicine kills cells", the medicine is the agent causing the death of the cells. This is a biological process. Sense 1 is the most general and fits best for biological agents (like diseases or toxins) causing death.

    Wait, let me double-check if "deprive of life" is strictly for organisms. Cells are the basic unit of life.

    Let's look at Sense 4 again: "cause to die; put to death". This is also very close. However, "put to death" often implies a more active, execution-style or slaughter-style killing.

    Let's re-examine Sense 1: "deprive of life". This is the most fundamental definition of kill.

    Let's check other options one more time.
    Sense 3: "be fatal". "Cigarettes kill". This is used when the subject is the cause of death in a general sense. "A medicine that kills cells" - here "kills" is used transitively with "cells" as the object. Sense 3 is often used intransitively.

    Comparing Sense 1 and Sense 4 again:
    Sense 1: `deprive of life`
    Sense 4: `cause to die; put to death, usually intentionally or knowingly`

    If I have to choose the *best* one:
    "AIDS has killed thousands" (Sense 1)
    "A medicine kills cells" (Sense 1)
    Both describe a biological agent causing death.

    "This man killed several people" (Sense 4)
    "The farmer killed a pig" (Sense 4)
    Both describe a conscious agent killing.

    Therefore, Sense 1 is the better fit.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cells
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
3. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
4. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
7. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 6}
```

content:
```json
{"sense_index": 6}
```

reasoning_content:
*   Target lemma: `cell`
    *   Target surface form: `cells`
    *   Context: "...a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells)..." and "...the genetic material of cells)."
    *   Candidate senses:
        1.  Small compartment (honeycomb).
        2.  Electric cell.
        3.  Monk/nun room.
        4.  Prison cell.
        5.  Mobile phone.
        6.  (Biology) basic structural and functional unit of all organisms.
        7.  Political movement unit.

    *   The context mentions "cytotoxic medicine", "cancer cells", "dividing", "DNA and RNA", and "genetic material".
    *   This is clearly referring to biological cells.

    *   Sense 6: "(biology) the basic structural and functional unit of all organisms..." matches perfectly.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: divide
Target surface form: dividing
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=divide%2:42:00:: | definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries
2. sense_key=divide%2:35:01:: | definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea
3. sense_key=divide%2:38:00:: | definition=make a division or separation | synonyms=separate
4. sense_key=divide%2:41:00:: | definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire after World War I
5. sense_key=divide%2:31:00:: | definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven?
6. sense_key=divide%2:35:00:: | definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 4}
```

content:
```json
{"sense_index": 4}
```

reasoning_content:
*   Target lemma: `divide`
    *   Target surface form: `dividing`
    *   Context: "...a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells)..."
    *   Meaning: In biology, cells "divide" to reproduce (mitosis/meiosis). This involves one cell splitting into two daughter cells.

    *   Sense 1: act as a barrier between; stand between (e.g., mountain range divides countries). -> Incorrect.
    *   Sense 2: force, take, or pull apart (e.g., separated fighting children). -> Incorrect.
    *   Sense 3: make a division or separation. -> Too general, but possible.
    *   Sense 4: separate into parts or portions (e.g., divide the cake). -> This describes the process of splitting one thing into multiple parts.
    *   Sense 5: perform a division (mathematical). -> Incorrect.
    *   Sense 6: come apart (e.g., glued pieces separated). -> Incorrect.

    *   Cell division is the process by which a parent cell divides into two or more daughter cells.
    *   Sense 4 ("separate into parts or portions") fits the biological process of a cell splitting into two.
    *   Sense 3 ("make a division or separation") is very vague.
    *   Sense 6 ("come apart") implies a failure of adhesion or a break, whereas cell division is a controlled biological process of splitting.

    *   Wait, let me look at the senses again. Is there a specific biological sense? No, these are general senses.
    *   "Cells that are dividing" means cells undergoing mitosis.
    *   Mitosis is the act of one cell splitting into two.
    *   Sense 4: "separate into parts or portions" (synonyms: split, split up). This is the closest description of cell division among the choices.

    *   Sense 1: Barrier. (No)
    *   Sense 2: Force apart. (No)
    *   Sense 3: Make a division. (Too vague)
    *   Sense 4: Separate into parts or portions. (Yes, splitting one cell into two)
    *   Sense 5: Math. (No)
    *   Sense 6: Come apart. (No)

    *   Sense 4 is the most accurate description of the physical process of cell division (splitting one entity into multiple entities).


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: body
Target surface form: body
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=body%1:14:02:: | definition=a collection of particulars considered as a system | examples=a body of law; a body of doctrine
2. sense_key=body%1:07:00:: | definition=the property of holding together and retaining its shape | synonyms=consistency, consistence, eubstance | examples=wool has more body than rayon; when the dough has enough consistency it is ready to bake
3. sense_key=body%1:06:01:: | definition=a resonating chamber in a musical instrument (as the body of a violin) | synonyms=soundbox
4. sense_key=body%1:17:00:: | definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. sense_key=body%1:10:00:: | definition=the central message of a communication | examples=the body of the message was short
6. sense_key=body%1:08:02:: | definition=a natural object consisting of a dead animal or person | synonyms=dead body | examples=they found the body in the lake
7. sense_key=body%1:06:00:: | definition=the external structure of a vehicle | examples=the body of the car was badly rusted
8. sense_key=body%1:08:00:: | definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
9. sense_key=body%1:08:01:: | definition=the body excluding the head and neck and limbs | synonyms=torso, trunk | examples=they moved their arms and legs and bodies
10. sense_key=body%1:07:01:: | definition=the main mass of a thing
11. sense_key=body%1:14:00:: | definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium; the student body

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 8}
```

content:
```json
{"sense_index": 8}
```

reasoning_content:
*   Target lemma: "body"
    *   Target surface form: "body"
    *   Context: "In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes..."
    *   Meaning: The context describes a medical process where a drug (pemetrexed) is converted into an active form within the human/animal organism.

    *   1: collection of particulars (e.g., body of law) - No.
    *   2: property of holding together (consistency) - No.
    *   3: resonating chamber (musical instrument) - No.
    *   4: 3D object with mass (heavenly body) - No.
    *   5: central message of communication - No.
    *   6: dead animal or person - No.
    *   7: external structure of a vehicle - No.
    *   8: entire structure of an organism (animal, plant, or human being) - Yes.
    *   9: body excluding head, neck, limbs (torso) - No.
    *   10: main mass of a thing - No.
    *   11: group of persons (student body) - No.

    *   The sentence "In the body, pemetrexed is converted..." clearly refers to the biological organism of the patient.
    *   Sense 8: "the entire structure of an organism (an animal, plant, or human being)" fits perfectly.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: convert
Target surface form: converted
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=convert%2:33:01:: | definition=complete successfully | examples=score a penalty shot or free throw
2. sense_key=convert%2:30:07:: | definition=cause to adopt a new or different faith | examples=The missionaries converted the Indian population
3. sense_key=convert%2:32:00:: | definition=make (someone) agree, understand, or realize the truth or validity of something | synonyms=win over, convince | examples=He had finally convinced several customers of the advantages of his product
4. sense_key=convert%2:30:04:: | definition=change in nature, purpose, or function; undergo a chemical change | examples=The substance converts to an acid
5. sense_key=convert%2:33:02:: | definition=score an extra point or points after touchdown by kicking the ball through the uprights or advancing the ball into the end zone | examples=Smith converted and his team won
6. sense_key=convert%2:30:09:: | definition=exchange a penalty for a less severe one | synonyms=commute, exchange
7. sense_key=convert%2:30:03:: | definition=change the nature, purpose, or function of something | examples=convert lead into gold; convert hotels into jails
8. sense_key=convert%2:30:00:: | definition=change from one system to another or to a new plan or policy | synonyms=change over | examples=We converted from 220 to 110 Volt
9. sense_key=convert%2:30:01:: | definition=change religious beliefs, or adopt a religious belief | examples=She converted to Buddhism
10. sense_key=convert%2:30:02:: | definition=exchange or replace with another, usually of the same kind or category | synonyms=change, exchange, commute | examples=Could you convert my dollars into pounds?; He changed his name
11. sense_key=convert%2:33:00:: | definition=score (a spare)

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 4}
```

reasoning_content:
*   Target lemma: `convert`
    *   Target surface form: `converted`
    *   Context: "In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes..."
    *   Meaning: Pemetrexed (a chemical substance/medicine) changes into another form (an active form) within the body. This is a chemical transformation.

    *   1: complete successfully (sports) - No.
    *   2: cause to adopt a new faith - No.
    *   3: make someone agree/understand - No.
    *   4: change in nature, purpose, or function; undergo a chemical change (Example: "The substance converts to an acid") - Yes, this fits perfectly.
    *   5: score extra points (sports) - No.
    *   6: exchange a penalty - No.
    *   7: change the nature, purpose, or function of something (Example: "convert lead into gold") - This is the transitive version (changing *something else*). The context is "pemetrexed is converted" (passive voice, meaning pemetrexed undergoes the change).
    *   8: change from one system to another - No.
    *   9: change religious beliefs - No.
    *   10: exchange or replace with another (currency/name) - No.
    *   11: score (a spare) - No.

    *   Sense 4: "change in nature, purpose, or function; undergo a chemical change" (Intransitive/Passive use: "The substance converts to an acid").
    *   Sense 7: "change the nature, purpose, or function of something" (Transitive use: "convert lead into gold").
    *   The sentence "pemetrexed is converted into an active form" is the passive form of "the body converts pemetrexed into an active form" or "pemetrexed converts into an active form".
    *   Looking at the examples: Sense 4's example "The substance converts to an acid" matches the chemical transformation context perfectly.

    *   Sense 4 is the best fit for a chemical change.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
4. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
5. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession
6. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
7. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
11. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
12. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
13. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
14. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 13}
```

content:
```json
{"sense_index": 13}
```

reasoning_content:
*   Target lemma: `active`
    *   Target surface form: `active`
    *   Context: "In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes..."
    *   Meaning: The drug (pemetrexed) is converted into a form that is chemically capable of producing a biological effect (blocking enzymes).

    *   1: full of activity (seaport, bond market) - No.
    *   2: military operations (combat-ready) - No.
    *   3: volcanoes erupting - No.
    *   4: becoming more severe (tuberculosis) - No.
    *   5: full-time work - No.
    *   6: disposed to take action (director) - No.
    *   7: grammar (subject as actor) - No.
    *   8: in operation (hope alive) - No.
    *   9: sunspots/flares - No.
    *   10: energetic activity (toddler) - No.
    *   11: volcanoes capable of erupting - No.
    *   12: taking part in an activity (member of club) - No.
    *   13: exerting influence or producing a change or effect (example: "an active ingredient") - Yes.
    *   14: verbs expressing action rather than state - No.

    *   The context describes a drug being converted into a form that "blocks the activity of the enzymes". This is exactly what an "active ingredient" or an "active form" of a drug does—it produces a biological effect.
    *   Sense 13: "exerting influence or producing a change or effect" with the example "an active ingredient". This fits perfectly.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: form
Target surface form: form
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=form%1:09:01:: | definition=a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety | examples=sculpture is a form of art; what kinds of desserts are there?
2. sense_key=form%1:07:00:: | definition=the visual appearance of something or someone | synonyms=shape, cast | examples=the delicate cast of his features
3. sense_key=form%1:07:03:: | definition=a particular mode in which something is manifested | examples=his resentment took the form of extreme hostility
4. sense_key=form%1:10:02:: | definition=an arrangement of the elements in a composition or discourse | examples=the essay was in the form of a dialogue; he first sketches the plot in outline form
5. sense_key=form%1:08:00:: | definition=alternative names for the body of a human being | synonyms=human body, physical body, material body, soma, build, figure | examples=Leonardo studied the human body; he has a strong physique
6. sense_key=form%1:14:02:: | definition=(biology) a group of organisms within a species that differ in trivial ways from similar groups | synonyms=variant, strain, var. | examples=a new strain of microorganisms
7. sense_key=form%1:06:01:: | definition=a mold for setting concrete | examples=they built elaborate forms for pouring the foundation
8. sense_key=form%1:03:00:: | definition=the spatial arrangement of something as distinct from its substance | synonyms=shape | examples=geometry is the mathematical science of shape
9. sense_key=form%1:26:00:: | definition=(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary | synonyms=phase | examples=the reaction occurs in the liquid phase of the system
10. sense_key=form%1:10:00:: | definition=the phonological or orthographic sound or appearance of a word that can be used to describe or identify something | synonyms=word form, signifier, descriptor | examples=the inflected forms of a word can be represented by a stem and a list of inflections to be attached
11. sense_key=form%1:07:02:: | definition=an ability to perform well | examples=he was at the top of his form; the team was off form last night
12. sense_key=form%1:07:01:: | definition=any spatial attributes (especially as defined by outline) | synonyms=shape, configuration, contour, conformation | examples=he could barely make out their shapes
13. sense_key=form%1:06:00:: | definition=a life-size dummy used to display clothes | synonyms=mannequin, manikin, mannikin, manakin
14. sense_key=form%1:14:00:: | definition=a body of students who are taught together | synonyms=class, grade, course | examples=early morning classes are always sleepy
15. sense_key=form%1:09:00:: | definition=a perceptual structure | synonyms=shape, pattern | examples=the composition presents problems for students of musical form; a visual pattern must include not only objects but the spaces between them
16. sense_key=form%1:10:01:: | definition=a printed document with spaces in which to write | examples=he filled out his tax form

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target word: "form"
    *   Context: "In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes..."
    *   Meaning: Pemetrexed (a drug) is converted into a specific version or state (active form) that performs a biological function.

    *   1: category of things (kind, sort, variety) - "sculpture is a form of art"
    *   2: visual appearance (shape, cast) - "delicate cast of his features"
    *   3: particular mode in which something is manifested - "resentment took the form of extreme hostility"
    *   4: arrangement of elements in composition/discourse - "essay was in the form of a dialogue"
    *   5: human body (physique) - "Leonardo studied the human body"
    *   6: (biology) group of organisms within a species (variant, strain) - "new strain of microorganisms"
    *   7: mold for concrete - "forms for pouring the foundation"
    *   8: spatial arrangement vs substance (shape) - "geometry is the mathematical science of shape"
    *   9: (physical chemistry) distinct state of matter/phase - "liquid phase of the system"
    *   10: phonological/orthographic sound/appearance of a word - "inflected forms of a word"
    *   11: ability to perform well - "top of his form"
    *   12: spatial attributes/outline (shape, configuration) - "barely make out their shapes"
    *   13: mannequin - "life-size dummy"
    *   14: body of students (class, grade) - "early morning classes"
    *   15: perceptual structure (shape, pattern) - "musical form"
    *   16: printed document - "tax form"

    *   The context describes a chemical/biological conversion: "pemetrexed is converted into an active form".
    *   This isn't a "category" (Sense 1), a "visual shape" (Sense 2, 8, 12), a "phase of matter" (Sense 9 - though close, "active form" in pharmacology usually refers to the active metabolite or a specific chemical manifestation), or a "strain of organism" (Sense 6).
    *   Sense 3: "a particular mode in which something is manifested". This fits well. The drug manifests as an "active form" (the active metabolite).
    *   Let's re-evaluate Sense 1: "a category of things distinguished by some common characteristic or quality". "Active form" could be seen as a "kind" of pemetrexed.
    *   Let's re-evaluate Sense 9: "a distinct state of matter in a system... identical in chemical composition and physical state". This is too specific to physical chemistry phases (solid, liquid, gas).
    *   Comparing Sense 1 and Sense 3:
        *   Sense 1: "sculpture is a form of art" (category).
        *   Sense 3: "resentment took the form of extreme hostility" (manifestation).
    *   In pharmacology, "active form" refers to the specific chemical structure/state that is biologically active. This is a manifestation of the drug's activity.
    *   Wait, let's look at Sense 1 again: "kind, sort, variety". "An active form" = "an active kind/variety" of the substance.
    *   Let's look at Sense 3 again: "a particular mode in which something is manifested".
    *   Actually, in many medical contexts, "active form" is treated as a "type" or "kind" (Sense 1). However, "manifested" (Sense 3) also works.
    *   Let's check if there's a better fit.
    *   Sense 1: "a category of things distinguished by some common characteristic or quality".
    *   Sense 3: "a particular mode in which something is manifested".
    *   If we say "the active form of the drug", we mean the specific chemical version that is active. This is more of a "kind" or "variety" (Sense 1) than a "mode of manifestation" (Sense 3).
    *   Wait, let's look at Sense 1 examples: "sculpture is a form of art".
    *   Let's look at Sense 3 examples: "his resentment took the form of extreme hostility".
    *   "Pemetrexed is converted into an active form" -> Pemetrexed becomes a specific version of itself.
    *   Is it a "category" (Sense 1) or a "mode of manifestation" (Sense 3)?
    *   Usually, "active form" in chemistry/pharmacology refers to the specific molecular structure. This is a "kind" or "variety" of the substance.
    *   Let's double-check Sense 1 synonyms: kind, sort, variety. "An active variety of pemetrexed."
    *   Let's double-check Sense 3: "a particular mode in which something is manifested."
    *   Actually, looking at how these are often tagged in WSD datasets (like SemCor), "form" in "active form of a drug" often maps to the sense of "kind" or "type".

    *   Sense 1: category, kind, sort, variety.
    *   Sense 3: particular mode in which something is manifested.
    *   "Active form" = "Active version/kind".
    *   If I say "The drug exists in two forms: active and inactive," I am talking about two kinds/varieties.

    *   Sense 1: "a category of things distinguished by some common characteristic or quality"
    *   Sense 3: "a particular mode in which something is manifested"
    *   In "converted into an active form", the drug changes its chemical structure to become the active version. This is a specific "kind" of the molecule.

    *   Sense 1: sculpture is a form of art. (Category)
    *   Sense 3: resentment took the form of hostility. (Manifestation)
    *   "Active form" is more like "active kind" than "active manifestation".

    *   Sense 1: kind, sort, variety.
    *   Sense 3: (no synonyms provided).
    *   "Active form" -> "Active variety". This fits well.

    *   Sense 9: "a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary".
    *   This is definitely not it, as the chemical composition changes (pemetrexed is converted/metabolized).

    *   Sense 1 is the most general and fits "kind/variety" of a chemical substance.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: block
Target surface form: blocks
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=block%2:35:00:: | definition=render unsuitable for passage | synonyms=barricade, blockade, stop, block off, block up, bar | examples=block the way; barricade the streets
2. sense_key=block%2:35:06:: | definition=support, secure, or raise with a block | examples=block a plate for printing; block the wheels of a car
3. sense_key=block%2:39:05:: | definition=interrupt the normal function of by means of anesthesia | examples=block a nerve; block a muscle
4. sense_key=block%2:35:03:: | definition=stamp or emboss a title or design on a book with a block | examples=block the book cover
5. sense_key=block%2:30:01:: | definition=shape by using a block | examples=Block a hat; block a garment
6. sense_key=block%2:41:01:: | definition=stop from happening or developing | synonyms=stop, halt, kibosh | examples=Block his election; Halt the process
7. sense_key=block%2:39:00:: | definition=shut out from view or get in the way so as to hide from sight | synonyms=obstruct | examples=The thick curtain blocked the action on the stage; The trees obstruct my view of the mountains
8. sense_key=block%2:35:12:: | definition=block passage through | synonyms=obstruct, obturate, impede, occlude, jam, close up | examples=obstruct the path
9. sense_key=block%2:31:00:: | definition=be unable to remember | synonyms=forget, blank out, draw a blank | examples=I'm drawing a blank; You are blocking the name of your first wife!
10. sense_key=block%2:41:00:: | definition=hinder or prevent the progress or accomplishment of | synonyms=obstruct, blockade, hinder, stymie, stymy, embarrass | examples=His brother blocked him at every turn
11. sense_key=block%2:41:03:: | definition=run on a block system | examples=block trains
12. sense_key=block%2:35:02:: | definition=obstruct | synonyms=stuff, lug, choke up | examples=My nose is all stuffed; Her arteries are blocked
13. sense_key=block%2:30:00:: | definition=shape into a block or blocks | examples=block the graphs so one can see the results clearly
14. sense_key=block%2:30:02:: | definition=prohibit the conversion or use of (assets) | synonyms=freeze, immobilize, immobilise | examples=Blocked funds; Freeze the assets of this hostile government
15. sense_key=block%2:33:00:: | definition=impede the movement of (an opponent or a ball) | synonyms=parry, deflect | examples=block an attack
16. sense_key=block%2:32:00:: | definition=interfere with or prevent the reception of signals | synonyms=jam | examples=Jam the Voice of America; block the signals emitted by this station

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 6}
```

reasoning_content:
*   Target lemma: `block`
    *   Target surface form: `blocks`
    *   Context: "...pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides..."
    *   Meaning: In this biological/chemical context, "blocks" means to inhibit or stop the activity of enzymes.

    *   1: render unsuitable for passage (physical barrier)
    *   2: support, secure, or raise with a block (physical support)
    *   3: interrupt the normal function of by means of anesthesia (medical, but specific to anesthesia)
    *   4: stamp or emboss (printing)
    *   5: shape by using a block (clothing/hats)
    *   6: stop from happening or developing (general process/event)
    *   7: shut out from view (visual)
    *   8: block passage through (physical obstruction)
    *   9: be unable to remember (mental)
    *   10: hinder or prevent the progress or accomplishment of (general hindrance)
    *   11: run on a block system (trains)
    *   12: obstruct (physical blockage, e.g., arteries)
    *   13: shape into a block (formatting)
    *   14: prohibit the conversion or use of assets (financial)
    *   15: impede movement of opponent/ball (sports/combat)
    *   16: interfere with signals (electronic)

    *   The context is "blocks the activity of the enzymes".
    *   This is a biological inhibition.
    *   Sense 6: "stop from happening or developing" (e.g., "Halt the process").
    *   Sense 10: "hinder or prevent the progress or accomplishment of".
    *   Sense 8/12: Physical obstruction.
    *   Sense 3: Anesthesia (too specific).

    Let's re-evaluate Sense 6 vs Sense 10.
    Sense 6: "stop from happening or developing" (synonyms: stop, halt, kibosh).
    Sense 10: "hinder or prevent the progress or accomplishment of" (synonyms: obstruct, blockade, hinder, stymie).

    Wait, is there a better sense? Let's look at the options again.
    "blocks the activity of the enzymes"
    In biochemistry, "blocking an enzyme" means inhibiting its function.
    Sense 6 ("stop from happening or developing") fits "the activity of the enzymes" (stopping the activity).
    Sense 10 ("hinder or prevent the progress or accomplishment of") fits "the activity" (preventing the accomplishment of the enzyme's function).

    Let's look at Sense 6 examples: "Block his election; Halt the process".
    Let's look at Sense 10 examples: "His brother blocked him at every turn".

    Actually, looking at the list again, is there a sense for "inhibit"?
    Sense 6: "stop from happening or developing" -> "stop the activity".
    Sense 10: "hinder or prevent the progress or accomplishment of".

    Let's compare with Sense 8/12. Sense 12 mentions "arteries are blocked", which is physical. Enzyme blocking is often conceptualized as physical (blocking the active site), but the result is stopping the activity.

    Let's re-read Sense 6: "stop from happening or developing".
    Let's re-read Sense 10: "hinder or prevent the progress or accomplishment of".

    In the context of "blocks the activity of the enzymes", the activity is being stopped or prevented.
    Sense 6 seems slightly more aligned with "stopping a process" (the activity of the enzyme is a process).

    Wait, let me check if there's a more specific sense I missed.
    Sense 3: "interrupt the normal function of by means of anesthesia". (No)
    Sense 8: "block passage through". (No)
    Sense 12: "obstruct" (e.g., arteries). (No)

    Let's look at Sense 6 again: "stop from happening or developing".
    If you block the activity of an enzyme, you stop that activity from happening.

    Let's look at Sense 10 again: "hinder or prevent the progress or accomplishment of".
    This is often used for people or goals.

    Let's consider if "block" in "block the activity" is closer to "stop" (Sense 6) or "hinder" (Sense 10).
    In medical/scientific texts, "block" usually means to inhibit completely or significantly. "Stop" is a closer synonym for "inhibit" in this context than "hinder".

    Let's double-check Sense 6 synonyms: stop, halt, kibosh.
    Let's double-check Sense 10 synonyms: obstruct, blockade, hinder, stymie.

    "Stop the activity" vs "Hinder the activity".
    "Stop" is a very common way to describe enzyme inhibition.

    Wait, let me look at Sense 6 again. "Block his election; Halt the process".
    "Halt the process" is very similar to "block the activity of the enzymes".

    Let's check if any other sense fits better.
    Sense 1: "render unsuitable for passage" (No)
    Sense 8: "block passage through" (No)
    Sense 12: "obstruct" (No)

    Comparing 6 and 10 again:
    6: stop from happening or developing.
    10: hinder or prevent the progress or accomplishment of.

    "Activity of the enzymes" is a process. Stopping a process is Sense 6.

    Let's think about "block" in a biological sense. It often means the drug binds to the enzyme, preventing the substrate from binding. This is a physical obstruction of the active site.
    Does Sense 8 ("block passage through") or Sense 12 ("obstruct") fit?
    Sense 8: "block passage through" (e.g., obstruct the path).
    Sense 12: "obstruct" (e.g., arteries are blocked).

    However, the target is "blocks the activity", not "blocks the enzyme".
    You don't "block passage through the activity". You "stop the activity".

    Therefore, Sense 6 ("stop from happening or developing") is the most logical fit for "blocks the activity".

    Wait, let me re-read Sense 10 one more time. "hinder or prevent the progress or accomplishment of".
    If the "activity" is seen as the "accomplishment" of the enzyme's function, Sense 10 could work. But "stop from happening" (Sense 6) is more direct for "blocking activity".

    Let's search for "block the activity of" in a corpus or dictionary.
    Usually, "block" in this context means "to inhibit".
    Inhibiting an enzyme means stopping its activity.

    Let's look at the examples for Sense 6 again: "Halt the process".
    The activity of an enzyme is a biological process.

    Let's look at Sense 10 again: "His brother blocked him at every turn". (This is more about interpersonal obstruction).

    Conclusion: Sense 6 is the best fit.