[User]
Which numbered sense of "have" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who <t>have</t> certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Senses:
1. definition=have or possess, either in a concrete or an abstract sense | synonyms=have got, hold | examples=She has $1,000 in the bank; He has got two beautiful daughters
2. definition=have as a feature | synonyms=feature | examples=This restaurant features the most famous chefs in France
3. definition=go through (mental or physical states or experiences) | synonyms=experience, receive, get | examples=get an idea; experience vertigo
4. definition=have ownership or possession of | synonyms=own, possess | examples=He owns three houses in Florida; How many cars does she have?
5. definition=cause to move; cause to be in a certain position or condition | synonyms=get, let | examples=He got his squad on the ball; This let me in for a big surprise
6. definition=serve oneself to, or consume regularly | synonyms=consume, ingest, take in, take | examples=Have another bowl of chicken soup!; I don't take sugar in my coffee
7. definition=have a personal or business relationship with someone | examples=have a postdoc; have an assistant
8. definition=organize or be responsible for | synonyms=hold, throw, make, give | examples=hold a reception; have, throw, or make a party
9. definition=have left | examples=I have two years left; I don't have any money left
10. definition=be confronted with | examples=What do we have here?; Now we have a fine mess
11. definition=undergo | synonyms=experience | examples=The stocks had a fast run-up
12. definition=suffer from; be ill with | examples=She has arthritis
13. definition=cause to do; cause to act in a specified manner | synonyms=induce, stimulate, cause, get, make | examples=The ads induced me to buy a VCR; My children finally got me to buy a computer
14. definition=receive willingly something given or offered | synonyms=accept, take | examples=The only girl who would have him was the miller's daughter; I won't have this dog in my house!
15. definition=get something; come into possession of | synonyms=receive | examples=receive payment; receive a gift
16. definition=undergo (as of injuries and illnesses) | synonyms=suffer, sustain, get | examples=She suffered a fracture in the accident; He had an insulin shock after eating three candy bars
17. definition=achieve a point or goal | synonyms=get, make | examples=Nicklaus had a 70; The Brazilian team got 4 goals
18. definition=cause to be born | synonyms=give birth, deliver, bear, birth | examples=My wife had twins yesterday!
19. definition=have sex with; archaic use | synonyms=take | examples=He had taken this woman when she was most vulnerable

reasoning_content:
*   Context: "...Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who <t>have</t> certain other side effects."
    *   Target word: "have"
    *   Usage: "who have certain other side effects"

    *   1: possess (concrete/abstract) - "She has $1,000"
    *   2: feature - "This restaurant features..."
    *   3: go through (mental/physical states/experiences) - "experience vertigo"
    *   4: ownership/possession - "He owns three houses"
    *   5: cause to move/position - "He got his squad on the ball"
    *   6: consume - "Have another bowl of soup"
    *   7: relationship - "have a postdoc"
    *   8: organize - "hold a reception"
    *   9: have left - "I have two years left"
    *   10: be confronted with - "What do we have here?"
    *   11: undergo (stocks/trends) - "The stocks had a fast run-up"
    *   12: suffer from; be ill with - "She has arthritis"
    *   13: cause to do - "The ads induced me to buy"
    *   14: receive willingly - "I won't have this dog"
    *   15: get something - "receive payment"
    *   16: undergo (injuries and illnesses) - "She suffered a fracture", "He had an insulin shock"
    *   17: achieve a point/goal - "Nicklaus had a 70"
    *   18: give birth - "My wife had twins"
    *   19: have sex - "He had taken this woman"

    *   The phrase is "have certain other side effects".
    *   Side effects are medical conditions or symptoms resulting from a drug.
    *   Does "have" here mean "possess" (1), "experience" (3), "suffer from" (12), or "undergo" (16)?

    *   Sense 12: "suffer from; be ill with" (Example: "She has arthritis"). Arthritis is a chronic condition.
    *   Sense 16: "undergo (as of injuries and illnesses)" (Example: "She suffered a fracture", "He had an insulin shock"). Side effects are similar to these medical events/conditions.
    *   Sense 3: "go through (mental or physical states or experiences)" (Example: "experience vertigo"). Vertigo is a symptom/side effect.

    *   Sense 12 is often for chronic diseases.
    *   Sense 16 is for specific medical events or injuries.
    *   Sense 3 is for experiences/states.

    Let's look closer at Sense 16: "undergo (as of injuries and illnesses) | synonyms=suffer, sustain, get | examples=She suffered a fracture in the accident; He had an insulin shock after eating three candy bars".
    Side effects are essentially medical conditions or symptoms that a patient "gets" or "suffers" from.

    Let's look at Sense 12: "suffer from; be ill with | examples=She has arthritis".

    Comparing "have side effects" to "have arthritis" vs "have an insulin shock".
    "Side effects" are often temporary or specific reactions.

    Wait, let's look at Sense 3 again: "go through (mental or physical states or experiences) | synonyms=experience, receive, get | examples=get an idea; experience vertigo". Vertigo is a symptom.

    Let's re-evaluate Sense 16: "undergo (as of injuries and illnesses)". Side effects are illnesses/conditions.

    Actually, in many medical contexts, "have [symptom/side effect]" is mapped to "experience" or "suffer".

    Let's check Sense 16 again: "undergo (as of injuries and illnesses) | synonyms=suffer, sustain, get".
    Example: "He had an insulin shock". An insulin shock is a reaction/side effect of too much insulin. This matches "have side effects" very well.

    Let's check Sense 12: "suffer from; be ill with". This is usually for a disease (arthritis, cancer, diabetes).

    Let's check Sense 3: "go through (mental or physical states or experiences)". This is broader.

    Between 3, 12, and 16:
    - 12 is for diseases.
    - 16 is for medical events/injuries/shocks.
    - 3 is for states/experiences.

    "Side effects" are medical conditions/symptoms. "He had an insulin shock" (16) is very similar to "He had side effects".

    Let's double-check if there's a better fit.
    Sense 1: possess (abstract). "He has a cold" is sometimes put here, but usually, medical senses are separate.
    Sense 16 specifically mentions "injuries and illnesses" and gives the example "insulin shock". Side effects are essentially temporary illnesses or adverse reactions.

    Is "side effect" an illness? Yes, in a broad sense. Is it an injury? No. Is it an experience? Yes.

    Let's compare "have side effects" with "have vertigo" (Sense 3) and "have an insulin shock" (Sense 16).
    "Vertigo" is a symptom. "Side effects" are symptoms/conditions.
    "Insulin shock" is a reaction. "Side effects" are reactions.

    Wait, looking at the provided senses again:
    Sense 3: "go through (mental or physical states or experiences) | synonyms=experience, receive, get | examples=get an idea; experience vertigo"
    Sense 16: "undergo (as of injuries and illnesses) | synonyms=suffer, sustain, get | examples=She suffered a fracture in the accident; He had an insulin shock after eating three candy bars"

    "Side effects" are usually described as something a patient *experiences* or *suffers from*.
    If I say "I have a headache", is that Sense 3, 12, or 16?
    Headache is a symptom (like vertigo).
    Insulin shock is a more acute medical event.
    Side effects can be either.

    However, "have side effects" is most commonly synonymous with "experience side effects" or "suffer side effects".
    Sense 16 synonyms: suffer, sustain, get.
    Sense 3 synonyms: experience, receive, get.

    Let's look at the examples again.
    Sense 3: "experience vertigo"
    Sense 16: "had an insulin shock"

    "Side effects" are more like "insulin shock" (a reaction to a drug) than "vertigo" (a state of dizziness), although vertigo can be a side effect.

    Actually, looking at common NLP datasets (like WordNet or similar sense inventories this list seems to be derived from), "have" in the context of symptoms or side effects is often categorized under "experience" or "suffer".

    Let's re-read Sense 16: "undergo (as of injuries and illnesses)".
    Let's re-read Sense 12: "suffer from; be ill with".

    If the patient "has side effects", they are experiencing them.
    If the patient "has arthritis", they suffer from the disease.

    Side effects are not usually a disease you are "ill with" (Sense 12), but rather something you "undergo" or "experience" as a result of treatment.

    Comparing 3 and 16 again:
    3: experience vertigo
    16: had an insulin shock

    "Side effects" is a plural noun referring to the adverse reactions. "He had side effects" is very similar to "He had an insulin shock".

    Let's think about "have a cold". Is that 12 or 16? A cold is an illness.
    "Have a fracture" is 16.
    "Have side effects" feels closer to 16 (undergo/suffer) than 3 (experience a state).

    Wait, let me search for this specific sense list. It looks like it might be from a specific dictionary or dataset (like WordNet or a similar project).
    In many of these, "have" for symptoms/illnesses is split.
    Sense 12: chronic/disease.
    Sense 16: acute/injury/event.

    Side effects are often acute reactions.

    Let's double-check Sense 3: "go through (mental or physical states or experiences)".
    "Experience vertigo" is a physical state.
    "Have side effects" could be "experience side effects".

    Let's look at the context again: "...patients whose blood counts are abnormal or who have certain other side effects."
    This is a medical condition.

    If I have to choose between 3 and 16...
    Sense 16: "undergo (as of injuries and illnesses) | synonyms=suffer, sustain, get | examples=She suffered a fracture in the accident; He had an insulin shock after eating three candy bars"
    Sense 3: "go through (mental or physical states or experiences) | synonyms=experience, receive, get | examples=get an idea; experience vertigo"

    "Side effects" are often listed as "adverse effects" or "adverse reactions". "Insulin shock" is an adverse reaction.

    Let's try to see if "have side effects" fits better in 16.
    "Patients who suffer certain other side effects." (Fits 16)
    "Patients who experience certain other side effects." (Fits 3)

    Both work. But "suffer" is very common for side effects.

    Let's look at Sense 12 again: "suffer from; be ill with | examples=She has arthritis".
    Could "side effects" be "be ill with"? Not really.

    Let's look at Sense 16 again. "undergo (as of injuries and illnesses)".
    Is a side effect an illness? It can be.

    Let's compare "have side effects" with "have a heart attack". A heart attack is an event (Sense 16).
    "Have a fever". A fever is a symptom (Sense 3 or 16?).

    Actually, in many contexts, "have [medical condition]" is Sense 16 if it's an event or a specific ailment, and Sense 12 if it's a disease.

    Let's re-examine Sense 3: "experience vertigo". Vertigo is a symptom. Side effects are symptoms.

    Wait, I just noticed Sense 16 says "undergo (as of injuries and illnesses)".
    And Sense 3 says "go through (mental or physical states or experiences)".

    If "vertigo" (a symptom) is Sense 3, then "side effects" (symptoms) should also be Sense 3.

    Let's re-read:
    Sense 3: experience vertigo
    Sense 16: had an insulin shock

    Is there a difference between vertigo and an insulin shock?
    Vertigo is a sensation/state.
    Insulin shock is a medical emergency/condition.

    Side effects can be sensations (nausea, dizziness) or conditions (low white blood cell count, rash).

    Let's look at the context again: "patients whose blood counts are abnormal or who have certain other side effects."
    The "blood counts are abnormal" part is a condition. The "side effects" are similar.

    Let's think about the most likely answer in a test setting. Usually, "have side effects" is mapped to "experience" or "suffer".
    If "experience vertigo" is Sense 3, and "suffer a fracture/insulin shock" is Sense 16...

    Let's try to find this exact sense list online. It looks like it's from a dataset like WordNet or a similar lexical database.
    Searching for "have" senses...
    (Self-correction): This looks like it might be from the "WordNet" or "Oxford English Dictionary" simplified for a task.

    Let's re-evaluate Sense 16: "undergo (as of injuries and illnesses) | synonyms=suffer, sustain, get".
    "Suffer side effects" is a very common collocation.

    Let's re-evaluate Sense 3: "go through (mental or physical states or experiences) | synonyms=experience, receive, get".
    "Experience side effects" is also a very common collocation.

    Wait, let's look at the examples again.
    Sense 3: "get an idea; experience vertigo"
    Sense 16: "She suffered a fracture in the accident; He had an insulin shock after eating three candy bars"

    "Insulin shock" is a reaction to a substance (insulin).
    "Side effects" are reactions to a substance (Alimta).
    This is a very strong parallel.

    Let's check Sense 12 again: "suffer from; be ill with | examples=She has arthritis".
    Arthritis is a chronic disease. Side effects are usually not chronic diseases.

    So, between 3 and 16, 16 seems more specific to the "reaction to a substance/event" (like insulin shock) than 3 (like vertigo).

    Let's double-check.
    Sense 3: experience vertigo (a symptom)
    Sense 16: had an insulin shock (a reaction/condition)

    Side effects are reactions/conditions.

    Let's think about "have a headache".
    If "have vertigo" is 3, then "have a headache" is probably 3.
    If "have an insulin shock" is 16, then "have side effects" (which are reactions) is probably 16.

    Let's try to see if "side effects" are more like "vertigo" or "insulin shock".
    Side effects *include* vertigo.
    But "side effects" as a general term for adverse reactions to a drug is very similar to "insulin shock" (an adverse reaction to insulin).

    Let's consider Sense 16 again: "undergo (as of injuries and illnesses)".
    Is a side effect an illness? Not always, but it's a medical condition.

    Let's consider Sense 3 again: "go through (mental or physical states or experiences)".
    Is a side effect a physical state or experience? Yes.

    This is tough. Let's look at the synonyms.
    Sense 3: experience, receive, get.
    Sense 16: suffer, sustain, get.

    "Suffer side effects" is more common in medical literature than "receive side effects".
    "Experience side effects" is also very common.

    Let's look at the context: "Treatment should be delayed or discontinued... in patients... who have certain other side effects."
    This sounds like a clinical trial or a drug label. In this formal context, "suffer" or "experience" are both used.

    Wait, let's look at Sense 16's example again: "He had an insulin shock after eating three candy bars".
    This is a direct cause-and-effect: [Action: eating candy bars] -> [Result: insulin shock].
    The context is: [Action: treatment with Alimta] -> [Result: side effects].
    This matches the structure of the example in Sense 16 perfectly.

    Let's check Sense 3's example: "experience vertigo". There is no cause mentioned.

    Therefore, Sense 16 is the most likely fit.


attempt_kind: initial

status: success

[User]
Which numbered sense of "certain" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have <t>certain</t> other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Senses:
1. definition=definite but not specified or identified | examples=set aside a certain sum each week; to a certain degree
2. definition=having or feeling no doubt or uncertainty; confident and assured | synonyms=sure | examples=felt certain of success; was sure (or certain) she had seen it
3. definition=established beyond doubt or question; definitely known | examples=what is certain is that every effect must have a cause; it is certain that they were on the bus
4. definition=certain to occur; destined or inevitable; ; ; - Benjamin Franklin | synonyms=sure | examples=he was certain to fail; his fate is certain
5. definition=established irrevocably | synonyms=sealed | examples=his fate is sealed
6. definition=reliable in operation or effect | synonyms=sure | examples=a quick and certain remedy; a sure way to distinguish the two
7. definition=exercising or taking care great enough to bring assurance | synonyms=sure | examples=be certain to disconnect the iron when you are through; be sure to lock the doors

finish_reason: stop

role: assistant

reasoning_content:
*   Context: "...Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have <t>certain</t> other side effects."
    *   Target word: "certain"

    *   Sense 1: definite but not specified or identified (e.g., "a certain sum", "to a certain degree").
    *   Sense 2: having or feeling no doubt or uncertainty; confident (e.g., "felt certain of success").
    *   Sense 3: established beyond doubt or question; definitely known (e.g., "what is certain is...").
    *   Sense 4: certain to occur; destined or inevitable (e.g., "certain to fail").
    *   Sense 5: established irrevocably (e.g., "fate is sealed").
    *   Sense 6: reliable in operation or effect (e.g., "a quick and certain remedy").
    *   Sense 7: exercising or taking care great enough to bring assurance (e.g., "be certain to disconnect").

    *   The phrase is "certain other side effects".
    *   In this context, "certain" means "some specific" or "particular" side effects, but those side effects are not explicitly listed in this sentence.
    *   This matches the definition "definite but not specified or identified".

    *   Sense 1: "definite but not specified or identified" -> Matches perfectly.
    *   Sense 2: "confident" -> Does not match.
    *   Sense 3: "established beyond doubt" -> Does not match.
    *   Sense 4: "inevitable" -> Does not match.
    *   Sense 5: "irrevocably" -> Does not match.
    *   Sense 6: "reliable" -> Does not match.
    *   Sense 7: "taking care" -> Does not match.

currency: USD

source: unavailable


[User]
Which numbered sense of "other" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain <t>other</t> side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Senses:
1. definition=not the same one or ones already mentioned or implied; - the White Queen | examples=today isn't any other day; the construction of highways and other public works
2. definition=recently past | examples=the other evening
3. definition=belonging to the distant past | synonyms=early, former | examples=the early inhabitants of Europe; former generations
4. definition=very unusual; different in character or quality from the normal or expected; - Lance Morrow | examples=a strange, other dimension...where his powers seemed to fail

reasoning_content:
*   Context: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain <t>other</t> side effects."
    *   Target word: "other"
    *   Senses provided:
        1.  not the same one or ones already mentioned or implied.
        2.  recently past.
        3.  belonging to the distant past.
        4.  very unusual; different in character or quality from the normal or expected.

    *   The sentence discusses conditions under which treatment should be delayed, discontinued, or the dose reduced.
    *   Condition 1: blood counts are abnormal.
    *   Condition 2: certain *other* side effects.
    *   In this context, "other" refers to side effects that are not the "abnormal blood counts" already mentioned (or side effects in general, distinct from the specific blood count issue). It means "additional" or "different from the one(s) already mentioned."

    *   Sense 1: "not the same one or ones already mentioned or implied". This fits perfectly. The "abnormal blood counts" are mentioned, and "other side effects" refers to side effects besides those.
    *   Sense 2: "recently past". Does not fit.
    *   Sense 3: "belonging to the distant past". Does not fit.
    *   Sense 4: "very unusual; different in character or quality from the normal or expected". While side effects can be unusual, the word "other" here is used to distinguish them from the previously mentioned blood counts, not to describe their nature as "strange" or "unusual" in a metaphysical or extreme sense.

    *   The word "other" is used to indicate additional side effects beyond the abnormal blood counts. This aligns with Sense 1.


[User]
Which numbered sense of "side_effect" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other <t>side effects</t>. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Senses:
1. definition=a secondary and usually adverse effect of a drug or therapy | examples=severe headaches are one of the side effects of the drug
2. definition=any adverse and unwanted secondary effect | synonyms=fallout | examples=a strategy to contain the fallout from the accounting scandal

reasoning_content:
*   Context: A medical text about the drug Alimta, discussing dosage, administration, and the need to manage "side effects" (e.g., using corticosteroids, folic acid, anti-emetics). It mentions delaying treatment if patients have abnormal blood counts or "certain other side effects."
    *   Target word: "side effects" (marked with `<t></t>`).
    *   Senses:
        1.  A secondary and usually adverse effect of a drug or therapy.
        2.  Any adverse and unwanted secondary effect (synonym: fallout, e.g., from a scandal).

    *   The context is explicitly about a drug (Alimta) and its administration.
    *   The phrase "side effects" refers to the adverse reactions caused by the chemotherapy drug.
    *   Sense 1 specifically mentions "drug or therapy."
    *   Sense 2 is a more general term for negative consequences (like a scandal).

    *   Sense 1 is the correct fit.


[User]
Which numbered sense of "use" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for <t>use</t> in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Senses:
1. definition=the act of using | synonyms=usage, utilization, utilisation, employment, exercise | examples=he warned against the use of narcotic drugs; skilled in the utilization of computers
2. definition=what something is used for | synonyms=function, purpose, role | examples=the function of an auger is to bore holes; ballet is beautiful but what use is it?
3. definition=a particular service | examples=he put his knowledge to good use; patrons have their uses
4. definition=(economics) the utilization of economic goods to satisfy needs or in manufacturing | synonyms=consumption, economic consumption, usance, use of goods and services | examples=the consumption of energy has increased steadily
5. definition=(psychology) an automatic pattern of behavior in reaction to a specific situation; may be inherited or acquired through frequent repetition | synonyms=habit | examples=owls have nocturnal habits; she had a habit twirling the ends of her hair
6. definition=exerting shrewd or devious influence especially for one's own advantage | synonyms=manipulation | examples=his manipulation of his friends was scandalous
7. definition=(law) the exercise of the legal right to enjoy the benefits of owning property | synonyms=enjoyment | examples=we were given the use of his boat

reasoning_content:
*   Context: "Alimta is not recommended for <t>use</t> in patients with moderate or severe kidney problems."
    *   Target word: "use"

    *   Sense 1: the act of using (usage, utilization, employment). Example: "warned against the use of narcotic drugs".
    *   Sense 2: what something is used for (function, purpose, role). Example: "what use is it?".
    *   Sense 3: a particular service. Example: "put his knowledge to good use".
    *   Sense 4: (economics) utilization of economic goods. Example: "consumption of energy".
    *   Sense 5: (psychology) automatic pattern of behavior (habit). Example: "nocturnal habits".
    *   Sense 6: exerting shrewd or devious influence (manipulation). Example: "manipulation of his friends".
    *   Sense 7: (law) legal right to enjoy property. Example: "use of his boat".

    *   The sentence says "Alimta is not recommended for use in patients...".
    *   This means the *act of using* the drug Alimta is not recommended for these patients.
    *   This aligns perfectly with Sense 1: "the act of using" (synonyms: usage, utilization).

    *   Sense 2 (purpose) doesn't fit.
    *   Sense 3 (service) doesn't fit.
    *   Sense 4 (economics) doesn't fit.
    *   Sense 5 (habit) doesn't fit.
    *   Sense 6 (manipulation) doesn't fit.
    *   Sense 7 (law) doesn't fit.


[User]
Which numbered sense of "patient" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in <t>patients</t> with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Senses:
1. definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

reasoning_content:
*   Context: A medical text describing the dosage and administration of Alimta, mentioning "patients" in several places, specifically focusing on the sentence: "Alimta is not recommended for use in <t>patients</t> with moderate or severe kidney problems."
    *   Target word: "patients"
    *   Senses provided:
        1.  A person who requires medical care.
        2.  The semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause (linguistic term).

    *   The text is about a medication (Alimta), dosage, side effects, and contraindications (kidney problems).
    *   "patients with moderate or severe kidney problems" refers to people receiving medical treatment or being considered for it.

    *   Sense 1: "a person who requires medical care" - This fits perfectly.
    *   Sense 2: "the semantic role of an entity..." - This is a linguistic definition of "patient" (as in agent/patient), which is not applicable here.

    *   The correct sense is 1.


[User]
Which numbered sense of "moderate" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with <t>moderate</t> or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Senses:
1. definition=being within reasonable or average limits; not excessive or extreme | examples=moderate prices; a moderate income
2. definition=not extreme | synonyms=temperate | examples=a moderate penalty; temperate in his response to criticism
3. definition=marked by avoidance of extravagance or extremes | synonyms=restrained | examples=moderate in his demands; restrained in his response

reasoning_content:
*   Context: "Alimta is not recommended for use in patients with <t>moderate</t> or severe kidney problems."
    *   Target word: "moderate"
    *   Senses provided:
        1.  being within reasonable or average limits; not excessive or extreme (e.g., moderate prices, moderate income).
        2.  not extreme (synonym: temperate) (e.g., a moderate penalty, temperate response).
        3.  marked by avoidance of extravagance or extremes (synonym: restrained) (e.g., moderate in demands, restrained response).

    *   The word "moderate" describes "kidney problems."
    *   In a medical context, "moderate" usually refers to the severity of a condition.
    *   It's positioned as a level between "mild" and "severe" (though "mild" isn't explicitly mentioned, "severe" is).
    *   It means the kidney problems are not mild, but not yet severe; they are in the middle range of intensity/severity.

    *   Sense 1: "being within reasonable or average limits; not excessive or extreme." This fits the idea of a "middle" level of severity.
    *   Sense 2: "not extreme." This also fits, as "moderate" kidney problems are not "extreme" (severe).
    *   Sense 3: "marked by avoidance of extravagance or extremes." This refers to behavior or personality (restraint), which doesn't fit a medical condition.

    *   Sense 1 often refers to quantity or amount (prices, income).
    *   Sense 2 often refers to intensity or degree (penalty, response).
    *   Wait, let's look closer at the definitions provided.
    *   Sense 1: "being within reasonable or average limits; not excessive or extreme".
    *   Sense 2: "not extreme" (synonym: temperate).
    *   In medical terminology, "moderate" (as in moderate impairment) means it's not mild and not severe. It's an intermediate level.
    *   Comparing Sense 1 and Sense 2:
        *   Sense 1: "reasonable or average limits; not excessive or extreme".
        *   Sense 2: "not extreme".
    *   Actually, looking at standard dictionary definitions (like Oxford), "moderate" in the context of a condition (like moderate pain or moderate kidney failure) usually falls under the sense of "average in amount, intensity, quality, or degree."
    *   Sense 1 mentions "average limits" and "not excessive or extreme."
    *   Sense 2 mentions "not extreme" and "temperate." "Temperate" usually refers to climate or behavior.
    *   Let's re-evaluate Sense 1: "being within reasonable or average limits; not excessive or extreme". This fits the description of a medical condition's severity (not mild, not severe).

    *   Sense 1: "moderate prices; a moderate income" (Quantity/Amount/Level).
    *   Sense 2: "a moderate penalty; temperate in his response" (Intensity/Degree/Severity).
    *   Wait, "moderate penalty" is very similar to "moderate kidney problems" (degree of severity).
    *   Let's look at Sense 1 again: "reasonable or average limits". Kidney problems aren't "reasonable." They are "average" in the sense of being in the middle of the scale.
    *   Let's look at Sense 2 again: "not extreme". Severe is extreme. Moderate is not extreme.

    *Self-Correction:* Let's look at the provided examples again.
    Sense 1: moderate prices, moderate income. (Amount/Level)
    Sense 2: moderate penalty, temperate response. (Intensity/Degree)
    Sense 3: moderate in demands, restrained response. (Behavior/Restraint)

    "Moderate kidney problems" refers to the *degree* or *intensity* of the problem. This aligns better with Sense 2 ("moderate penalty").

    *Wait*, let me double-check Sense 1 again. "being within reasonable or average limits; not excessive or extreme".
    If we say "moderate kidney problems," we mean the severity is not excessive (not severe).

    Let's compare "moderate penalty" (Sense 2) and "moderate income" (Sense 1).
    A penalty's severity is being described.
    An income's amount is being described.
    Kidney problems' severity is being described.

    Therefore, Sense 2 is the most likely fit.

    *Wait*, let me re-read Sense 1: "being within reasonable or average limits; not excessive or extreme".
    Actually, in many dictionaries, "moderate" meaning "average in amount, intensity, quality, or degree" is one single sense. Here it's split.
    Sense 1: reasonable/average limits (prices, income).
    Sense 2: not extreme (penalty, response).

    "Moderate kidney problems" = not extreme kidney problems.
    "Moderate penalty" = not extreme penalty.

    This points to Sense 2.

    *Wait*, let me look at the examples again.
    Sense 1: moderate prices (not too high), moderate income (not too high).
    Sense 2: moderate penalty (not too harsh), temperate response (not too emotional).
    Sense 3: moderate in demands (not too greedy).

    "Moderate kidney problems" means the severity is not too high (not severe). This is most similar to "moderate penalty" (not too harsh).

    Let's double-check if "moderate" in medical terms is usually categorized as "average" or "not extreme."
    Mild -> Moderate -> Severe.
    Moderate is the middle ground. It is "not extreme."

    Sense 1: "being within reasonable or average limits; not excessive or extreme"
    Sense 2: "not extreme"

    This is a very subtle difference. Let's look at the synonyms.
    Sense 2 synonym: "temperate".
    Sense 3 synonym: "restrained".

    "Temperate" doesn't really fit kidney problems.
    "Reasonable or average limits" (Sense 1) might fit better if we consider the "average" part of the scale (Mild, Moderate, Severe).

    Let's re-read Sense 1: "being within reasonable or average limits; not excessive or extreme".
    Example: "moderate prices". Prices that are not too high or too low.
    Example: "moderate income". Income that is not too high or too low.
    "Moderate kidney problems". Problems that are not too mild or too severe.

    Let's re-read Sense 2: "not extreme".
    Example: "moderate penalty". A penalty that is not too severe.
    Example: "temperate in his response". A response that is not too extreme.

    Actually, "moderate kidney problems" is almost exactly like "moderate penalty" (not severe).

    Let's search for these specific sense definitions. They look like they might come from a specific dictionary (like Oxford).
    Oxford Learner's Dictionary:
    1. (of amount, intensity, quality, etc.) neither small nor large in size, amount, or degree. (moderate prices, moderate income)
    2. (of a person) avoiding extremes of behavior or thinking. (moderate views)
    3. (of a person) not extreme in their opinions or beliefs.

    Wait, the senses provided in the prompt are different. Let's look at them again.
    1. being within reasonable or average limits; not excessive or extreme | examples=moderate prices; a moderate income
    2. not extreme | synonyms=temperate | examples=a moderate penalty; temperate in his response to criticism
    3. marked by avoidance of extravagance or extremes | synonyms=restrained | examples=moderate in his demands; restrained in his response

    Comparing "moderate kidney problems" to the examples:
    - Moderate prices (Sense 1)
    - Moderate income (Sense 1)
    - Moderate penalty (Sense 2)
    - Temperate response (Sense 2)
    - Moderate demands (Sense 3)
    - Restrained response (Sense 3)

    "Moderate kidney problems" is a description of the *severity* of a condition.
    "Moderate penalty" is a description of the *severity* of a punishment.
    "Moderate prices" is a description of the *amount* of money.

    Therefore, Sense 2 is the closest match.

    *Self-Correction again:* Let me think about "moderate" in "moderate kidney problems" one more time.
    Is it "average" (Sense 1) or "not extreme" (Sense 2)?
    In medical terms, "moderate" is a specific grade.
    Mild = Grade 1
    Moderate = Grade 2
    Severe = Grade 3
    It is the middle grade. "Average" (Sense 1) might fit "middle grade."
    But "not extreme" (Sense 2) also fits, as "severe" is the extreme.

    Let's look at the examples again.
    Sense 1: prices, income. (These are quantities/amounts).
    Sense 2: penalty, response to criticism. (These are degrees of intensity/severity).
    Kidney problems (severity) fits better with penalty (severity) than with prices (amount).

    Final check:
    Sense 1: Amount/Quantity.
    Sense 2: Intensity/Severity.
    Sense 3: Behavior/Restraint.
    "Moderate kidney problems" = Intensity/Severity.

    Result: 2.


[User]
Which numbered sense of "severe" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or <t>severe</t> kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Senses:
1. definition=intensely or extremely bad or unpleasant in degree or quality | synonyms=terrible, wicked | examples=severe pain; a severe case of flu
2. definition=very strong or vigorous | synonyms=hard, knockout | examples=strong winds; a hard left to the chin
3. definition=severely simple | synonyms=austere, stark, stern | examples=a stark interior
4. definition=unsparing and uncompromising in discipline or judgment; - H.G.Wells | synonyms=spartan | examples=a parent severe to the pitch of hostility; a hefty six-footer with a rather severe mien
5. definition=causing fear or anxiety by threatening great harm | synonyms=dangerous, grave, grievous, serious, life-threatening | examples=a dangerous operation; a grave situation
6. definition=very bad in degree or extent | examples=a severe worldwide depression; the house suffered severe damage

reasoning_content:
*   Context: "Alimta is not recommended for use in patients with moderate or <t>severe</t> kidney problems."
    *   Target word: "severe"
    *   Contextual meaning: Referring to the degree of kidney problems (medical condition).

    *   Sense 1: "intensely or extremely bad or unpleasant in degree or quality" (e.g., severe pain, severe case of flu).
    *   Sense 2: "very strong or vigorous" (e.g., strong winds).
    *   Sense 3: "severely simple" (e.g., stark interior).
    *   Sense 4: "unsparing and uncompromising in discipline or judgment" (e.g., severe mien).
    *   Sense 5: "causing fear or anxiety by threatening great harm" (e.g., dangerous operation, grave situation).
    *   Sense 6: "very bad in degree or extent" (e.g., severe worldwide depression, severe damage).

    *   "Severe kidney problems" describes the intensity or degree of a medical condition.
    *   Sense 1 specifically mentions "a severe case of flu," which is a medical condition.
    *   Sense 6 mentions "very bad in degree or extent" (e.g., severe damage).
    *   Comparing Sense 1 and Sense 6: Sense 1 focuses on the *quality* or *unpleasantness* of the experience/condition (like pain or flu), while Sense 6 focuses on the *extent* of damage or depression.
    *   In medical terminology, "severe" (as in severe kidney problems) usually refers to the degree of impairment or the intensity of the condition.
    *   Let's look at Sense 1 again: "intensely or extremely bad or unpleasant in degree or quality".
    *   Let's look at Sense 6 again: "very bad in degree or extent".
    *   Actually, in many dictionaries, "severe" for medical conditions falls under the "extreme in degree" category.
    *   Looking at the examples: "severe case of flu" (Sense 1) is very similar to "severe kidney problems".
    *   Sense 6 examples: "severe worldwide depression", "severe damage". These are more about scale or impact on a system/structure.
    *   Sense 1 is the most fitting for a medical condition/symptom.

    *   Sense 1: "intensely or extremely bad or unpleasant in degree or quality" -> "severe case of flu" -> "severe kidney problems".
    *   Sense 6: "very bad in degree or extent" -> "severe damage".
    *   Medical conditions are typically categorized under the "extreme in degree" sense that relates to pain or illness.

    *   Wait, let me re-read Sense 1 and Sense 6 carefully.
    *   Sense 1: "intensely or extremely bad or unpleasant in degree or quality"
    *   Sense 6: "very bad in degree or extent"
    *   "Severe kidney problems" refers to the extent of the dysfunction.
    *   However, "severe case of flu" (Sense 1) is almost identical in usage to "severe kidney problems".

    *   Let's check if there's a better fit.
    *   Sense 5: "causing fear or anxiety by threatening great harm" (grave situation). This is more about the *consequence* than the *degree* of the condition itself.

    *   Comparing 1 and 6 again:
        1: "intensely or extremely bad or unpleasant in degree or quality" (Example: severe pain, severe case of flu)
        6: "very bad in degree or extent" (Example: severe worldwide depression, severe damage)

    *   "Kidney problems" are a medical condition. "Severe case of flu" is a medical condition. Therefore, Sense 1 is the most appropriate.


[User]
Which numbered sense of "problem" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney <t>problems</t>. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Senses:
1. definition=a state of difficulty that needs to be resolved | synonyms=job | examples=she and her husband are having problems; it is always a job to contact him
2. definition=a question raised for consideration or solution | examples=our homework consisted of ten problems to solve
3. definition=a source of difficulty | synonyms=trouble | examples=one trouble after another delayed the job; what's the problem?

reasoning_content:
*   Context: "Alimta is not recommended for use in patients with moderate or severe kidney <t>problems</t>."
    *   Target word: "problems"
    *   Senses provided:
        1.  A state of difficulty that needs to be resolved (e.g., relationship problems, a job).
        2.  A question raised for consideration or solution (e.g., math problems).
        3.  A source of difficulty (e.g., trouble, health issues).

    *   The phrase is "kidney problems".
    *   In a medical context, "kidney problems" refers to kidney dysfunction, diseases, or health issues affecting the kidneys.
    *   This is a "source of difficulty" or a medical condition causing trouble for the patient.

    *   Sense 1: "a state of difficulty that needs to be resolved" (often used for interpersonal or situational struggles).
    *   Sense 2: "a question raised for consideration or solution" (academic/logical problems).
    *   Sense 3: "a source of difficulty" (synonym: trouble).

    *   "Kidney problems" fits best with Sense 3 ("a source of difficulty" / "trouble"). While Sense 1 is similar, Sense 3 is more commonly used for physical ailments or malfunctions (e.g., "engine problems", "health problems").

    *   Sense 1: "she and her husband are having problems" (relational).
    *   Sense 2: "ten problems to solve" (academic).
    *   Sense 3: "one trouble after another delayed the job" (source of difficulty).

    Wait, let me re-evaluate Sense 1 vs Sense 3.
    Sense 1: "a state of difficulty that needs to be resolved"
    Sense 3: "a source of difficulty"

    In "kidney problems", the "problems" are the medical conditions themselves (the source of the difficulty).

    Let's look at common dictionary definitions for "problem" in medical contexts. Usually, it means a condition or disorder.
    Sense 3: "a source of difficulty" (synonym: trouble). "Kidney trouble" is a common synonym for "kidney problems".

    Sense 1 is more about a situation (e.g., "we have a problem here").
    Sense 2 is a puzzle/exercise.
    Sense 3 is a cause of trouble/malfunction.

    Therefore, Sense 3 is the most appropriate.


[User]
Which numbered sense of "more" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For <t>more</t> information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Senses:
1. definition=(comparative of `much' used with mass nouns) a quantifier meaning greater in size or amount or extent or degree | synonyms=more than | examples=more land; more support
2. definition=(comparative of `many' used with count nouns) quantifier meaning greater in number | examples=a hall with more seats; we have no more bananas

reasoning_content:
*   Context: "For <t>more</t> information, see the Summary of Product Characteristics..."
    *   Target word: "more"
    *   Senses provided:
        1.  Comparative of 'much' (mass nouns) - greater in size, amount, extent, or degree.
        2.  Comparative of 'many' (count nouns) - greater in number.

    *   The word "more" modifies "information".
    *   "Information" is an uncountable (mass) noun. You don't say "one information, two informations".

    *   Sense 1: Used with mass nouns (amount/extent).
    *   Sense 2: Used with count nouns (number).

    *   Since "information" is a mass noun, Sense 1 is the correct fit.


[User]
Which numbered sense of "information" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more <t>information</t>, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Senses:
1. definition=a message received and understood | synonyms=info
2. definition=knowledge acquired through study or experience or instruction
3. definition=formal accusation of a crime
4. definition=a collection of facts from which conclusions may be drawn | synonyms=data | examples=statistical data
5. definition=(communication theory) a numerical measure of the uncertainty of an outcome | synonyms=selective information, entropy | examples=the signal contained thousands of bits of information

reasoning_content:
*   Context: A medical text describing the administration, side effects, and precautions for a drug called Alimta. The specific sentence is: "For more <t>information</t>, see the Summary of Product Characteristics (also part of the EPAR)."
    *   Target word: "information"
    *   Senses provided:
        1.  a message received and understood (synonym: info)
        2.  knowledge acquired through study or experience or instruction
        3.  formal accusation of a crime
        4.  a collection of facts from which conclusions may be drawn (synonym: data)
        5.  (communication theory) a numerical measure of the uncertainty of an outcome (synonym: entropy)

    *   The sentence "For more information, see the Summary of Product Characteristics" is a standard phrase used to direct a reader to a source of further knowledge or details about a subject (in this case, a medication).
    *   It refers to facts, details, or knowledge about the drug.

    *   Sense 1: "a message received and understood". This is a bit too narrow/specific to a single instance of communication.
    *   Sense 2: "knowledge acquired through study or experience or instruction". This fits well. The "Summary of Product Characteristics" provides knowledge/facts about the drug.
    *   Sense 3: "formal accusation of a crime". Clearly incorrect.
    *   Sense 4: "a collection of facts from which conclusions may be drawn (data)". While the document contains facts, the phrase "for more information" usually refers to general knowledge/details rather than a dataset for analysis.
    *   Sense 5: "numerical measure of uncertainty". Clearly incorrect.

    *   In common usage, "for more information" refers to seeking further knowledge or details.
    *   Comparing Sense 1 and Sense 2: Sense 1 is often used for a specific piece of news or a message. Sense 2 is broader and covers the general acquisition of knowledge.
    *   Wait, let's look at Sense 1 again: "a message received and understood".
    *   Let's look at Sense 2 again: "knowledge acquired through study or experience or instruction".
    *   Actually, in many dictionaries (like WordNet, which these senses seem to mirror), "information" as in "facts provided or learned about something" is often categorized as knowledge.
    *   Let's re-evaluate Sense 1 vs Sense 2.
        *   Sense 1: "a message received and understood" (e.g., "I have information that the train is late").
        *   Sense 2: "knowledge acquired through study..." (e.g., "He has a lot of information on the subject").
    *   "For more information, see..." is asking the reader to acquire more knowledge/facts.

    *   Sense 1: a message received and understood.
    *   Sense 2: knowledge acquired through study or experience or instruction.
    *   Sense 4: a collection of facts from which conclusions may be drawn (data).

    In the context of "For more information, see [document]", the word "information" refers to the facts/knowledge contained within that document. This aligns best with Sense 2.

    *Self-Correction/Refinement:*
    Is it Sense 1? "For more info..."
    Is it Sense 2? "For more knowledge..."
    Is it Sense 4? "For more data..."

    Usually, "information" in this context means "facts provided or learned about something or someone". Sense 2 ("knowledge acquired through study...") is the closest match among the choices provided.

    Let's double-check Sense 1 again. "a message received and understood". This sounds more like a specific communication event.
    Sense 2 is more about the content of the knowledge.

    Let's look at the provided senses again.
    1. a message received and understood
    2. knowledge acquired through study or experience or instruction
    4. a collection of facts from which conclusions may be drawn

    If I say "I need more information about this drug," I am seeking knowledge.

    Sense 2 is the most appropriate.


[User]
Which numbered sense of "see" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Senses:
1. definition=perceive by sight or have the power to perceive by sight | examples=You have to be a good observer to see all the details; Can you see the bird in that tree?
2. definition=perceive (an idea or situation) mentally | synonyms=understand, realize, realise | examples=Now I see!; I just can't see your point
3. definition=perceive or be contemporaneous with | synonyms=witness, find | examples=We found Republicans winning the offices; You'll see a lot of cheating in this school
4. definition=imagine; conceive of; see in one's mind | synonyms=visualize, visualise, envision, project, fancy, figure | examples=I can't see him on horseback!; I can see what will happen
5. definition=deem to be | synonyms=consider, reckon, view, regard | examples=She views this quite differently from me; I consider her to be shallow
6. definition=get to know or become aware of, usually accidentally | synonyms=learn, hear, get word, get wind, pick up, find out | examples=I learned that she has two grown-up children; I see that you have been promoted
7. definition=see or watch | synonyms=watch, view, catch, take in | examples=view a show on television; This program will be seen all over the world
8. definition=come together | synonyms=meet, run into, encounter, run across, come across | examples=I'll probably see you at the meeting; How nice to see you again!
9. definition=find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, find out, ascertain, watch, learn | examples=I want to see whether she speaks French; See whether it works
10. definition=be careful or certain to do something; make certain of something | synonyms=check, insure, see to it, ensure, control, ascertain | examples=He verified that the valves were closed; See that the curtains are closed
11. definition=go to see for professional or business reasons | examples=You should see a lawyer; We had to see a psychiatrist
12. definition=go to see for a social visit | examples=I went to see my friend Mary the other day
13. definition=go to see a place, as for entertainment | synonyms=visit | examples=We went to see the Eiffel Tower in the morning
14. definition=take charge of or deal with | synonyms=attend, take care, look | examples=Could you see about lunch?; I must attend to this matter
15. definition=receive as a specified guest | examples=the doctor will see you now; The minister doesn't see anybody before noon
16. definition=date regularly; have a steady relationship with | synonyms=go steady, go out, date | examples=Did you know that she is seeing an older man?; He is dating his former wife again!
17. definition=see and understand, have a good eye | examples=The artist must first learn to see
18. definition=deliberate or decide | examples=See whether you can come tomorrow; let's see--which movie should we see tonight?
19. definition=observe as if with an eye | examples=The camera saw the burglary and recorded it
20. definition=observe, check out, and look over carefully or inspect | synonyms=examine | examples=The customs agent examined the baggage; I must see your passport before you can enter the country
21. definition=go or live through | synonyms=experience, go through | examples=We had many trials to go through; he saw action in Viet Nam
22. definition=accompany or escort | synonyms=escort | examples=I'll see you to the door
23. definition=match or meet | examples=I saw the bet of one of my fellow players
24. definition=make sense of; assign a meaning to | synonyms=interpret, construe | examples=What message do you see in this letter?; How do you interpret his behavior?

reasoning_content:
*   Context: "For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR)."
    *   Target word: "see"

    *   1: perceive by sight (literal)
    *   2: perceive mentally (understand)
    *   3: perceive/be contemporaneous with (witness)
    *   4: imagine/conceive
    *   5: deem to be (consider)
    *   6: get to know/become aware of (accidentally)
    *   7: see or watch (view a show)
    *   8: come together (meet)
    *   9: find out, learn, or determine with certainty (by making an inquiry or effort)
    *   10: be careful/certain to do something
    *   11: professional/business visit
    *   12: social visit
    *   13: visit a place
    *   14: take charge of/deal with
    *   15: receive as a guest
    *   16: date regularly
    *   17: see and understand (artistic eye)
    *   18: deliberate or decide
    *   19: observe as if with an eye (camera)
    *   20: observe, check out, look over carefully or inspect (examine)
    *   21: experience/go through
    *   22: accompany/escort
    *   23: match or meet
    *   24: make sense of/interpret

    *   "For more information, see the Summary of Product Characteristics..."
    *   In this context, "see" means "refer to" or "look at for information."
    *   Looking at the senses again:
        *   Sense 1 (perceive by sight) is too literal, though reading involves sight.
        *   Sense 9 (find out, learn, or determine with certainty, usually by making an inquiry or other effort) fits well. "See whether she speaks French" is similar to "See the Summary for more information" (look there to find out).
        *   Sense 20 (observe, check out, and look over carefully or inspect) is close, but "examine" is more about inspection than referring to a document for information.
        *   Wait, let me re-examine Sense 9: "find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, find out, ascertain, watch, learn | examples=I want to see whether she speaks French; See whether it works".
        *   Is there a better one? Let's look at Sense 1 again. "perceive by sight". In many dictionaries, "see" in the sense of "refer to" is listed under a sense related to looking at something to get information.
        *   Let's re-read Sense 9 again. "find out, learn, or determine with certainty... check...". "See the Summary" means "check the Summary".
        *   Let's check Sense 20 again. "observe, check out, and look over carefully or inspect | synonyms=examine".
        *   Let's look at Sense 7. "see or watch | synonyms=watch, view, catch, take in".

    *   "See the Summary of Product Characteristics" is a standard way of saying "Refer to the Summary of Product Characteristics."
    *   Looking at the provided senses, Sense 9 ("find out, learn, or determine with certainty, usually by making an inquiry or other effort") seems the most appropriate because referring to a document is an effort to find out or learn more information.
    *   Let's double-check if any other sense fits better.
    *   Sense 1: Perceive by sight. (Too simple)
    *   Sense 20: Examine. (Too intense)
    *   Sense 9: Find out/check. (Fits well: "Check the Summary for more information.")

    *   Sense 9: "find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, find out, ascertain, watch, learn | examples=I want to see whether she speaks French; See whether it works"
    *   Context: "For more information, see the Summary of Product Characteristics"
    *   This matches the "check" or "find out" aspect of Sense 9.

    *   Wait, let me look at Sense 1 again. Sometimes "see" in "see page 10" is just categorized as "perceive by sight" or a derivative of it. But Sense 9's "check" is a much stronger synonym for "refer to" in this context.
    *   Let's re-evaluate Sense 20: "observe, check out, and look over carefully or inspect | synonyms=examine". "See the Summary" isn't necessarily "examining" it in a critical way, but rather referring to it.
    *   Let's re-evaluate Sense 9: "find out, learn, or determine with certainty... check...". This fits "refer to for information" very well.

    *   Sense 9: "find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, find out, ascertain, watch, learn"
    *   Example: "See whether it works" (Check if it works).
    *   Context: "See the Summary of Product Characteristics" (Check the Summary of Product Characteristics).
    *   This seems the most accurate among the choices.


[User]
Which numbered sense of "product" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR). How does Alimta work?

Senses:
1. definition=commodities offered for sale | synonyms=merchandise, ware | examples=good business depends on having good merchandise; that store offers a variety of products
2. definition=an artifact that has been created by someone or some process | synonyms=production | examples=they improve their product every year; they export most of their agricultural production
3. definition=a quantity obtained by multiplication | synonyms=mathematical product | examples=the product of 2 and 3 is 6
4. definition=a chemical substance formed as a result of a chemical reaction | examples=a product of lime and nitric acid
5. definition=a consequence of someone's efforts or of a particular set of circumstances | examples=skill is the product of hours of practice; his reaction was the product of hunger and fatigue
6. definition=the set of elements common to two or more sets | synonyms=intersection, Cartesian product | examples=the set of red hats is the intersection of the set of hats and the set of red things

reasoning_content:
*   Context: A medical text describing the administration and precautions for a drug called Alimta. It mentions "Summary of <t>Product</t> Characteristics (also part of the EPAR)."
    *   Target word: "Product" (in "Summary of Product Characteristics").
    *   Senses provided:
        1.  Commodities offered for sale (merchandise).
        2.  An artifact created by someone or some process (production).
        3.  Mathematical product (multiplication).
        4.  Chemical substance formed by a reaction.
        5.  Consequence of efforts/circumstances.
        6.  Intersection of sets (Cartesian product).

    *   "Summary of Product Characteristics" (SmPC) is a standard regulatory document for medicines in the EU.
    *   In this context, "Product" refers to the medicinal product (the drug Alimta).
    *   A medicinal product is a commodity offered for sale (Sense 1) or an artifact created by a process (Sense 2).
    *   Let's re-evaluate Sense 1 vs Sense 2.
        *   Sense 1: "commodities offered for sale" (merchandise, ware).
        *   Sense 2: "an artifact that has been created by someone or some process" (production).
    *   In pharmaceutical contexts, a "product" (like a drug) is typically viewed as a commercial item (Sense 1) or the result of a manufacturing process (Sense 2).
    *   However, "Summary of Product Characteristics" is a formal term. The "product" here is the medicine itself.
    *   Looking at the options again:
        *   Sense 1: commodities offered for sale.
        *   Sense 2: an artifact created by someone or some process.
    *   Usually, in these types of NLP tasks (like WordNet-based disambiguation), a commercial drug is categorized as a "product" in the sense of a commodity/merchandise (Sense 1).

    *   Sense 1: merchandise, ware. (A drug is a commercial product).
    *   Sense 2: production, artifact. (A drug is manufactured).
    *   Sense 4: chemical substance formed as a result of a chemical reaction. (A drug is a chemical substance, but "Product Characteristics" refers to the commercial/regulatory entity, not just the chemical result of a reaction).

    *   "Summary of Product Characteristics" (SmPC) is the official document describing the properties of a medicinal *product*.
    *   In the context of pharmaceutical regulation, "product" refers to the medicine as a commercial entity.
    *   Comparing Sense 1 and Sense 2: Sense 1 is more aligned with the commercial/marketed nature of a drug.

    *   Sense 1: commodities offered for sale.
    *   Sense 2: an artifact that has been created by someone or some process.
    *   Sense 4: a chemical substance formed as a result of a chemical reaction.
    *   In the phrase "Summary of Product Characteristics", "Product" refers to the medicinal product. A medicinal product is a commodity sold to the public/hospitals.

    *Self-Correction:* Let's look at how "product" is used in "Summary of Product Characteristics". It refers to the drug as a marketed item. Sense 1 fits best.

    *Wait, let me double-check Sense 2.* "An artifact that has been created by someone or some process." This is very broad.
    *Sense 1* is more specific to things sold.

    Let's look at the examples for Sense 1: "that store offers a variety of products".
    Let's look at the examples for Sense 2: "they improve their product every year".

    In the pharmaceutical industry, the "product" is the drug being sold.

    Let's consider Sense 4 again: "a chemical substance formed as a result of a chemical reaction". While a drug is a chemical, the "Summary of Product Characteristics" covers more than just the chemical reaction; it covers the dosage, side effects, and indications of the commercial drug.

    Therefore, Sense 1 is the most appropriate.


[User]
Which numbered sense of "part" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR). How does Alimta work?

Senses:
1. definition=something determined in relation to something that includes it | synonyms=portion, component part, component, constituent | examples=he wanted to feel a part of something bigger than himself; I read a portion of the manuscript
2. definition=something less than the whole of a human artifact | synonyms=portion | examples=the rear part of the house; glue the two parts together
3. definition=a portion of a natural object | synonyms=piece | examples=they analyzed the river into three parts; he needed a piece of granite
4. definition=that which concerns a person with regard to a particular role or situation | examples=it requires vigilance on our part; they resisted every effort on his part
5. definition=the extended spatial location of something | synonyms=region | examples=the farming regions of France; religions in all parts of the world
6. definition=the actions and activities assigned to or required or expected of a person or group | synonyms=function, office, role | examples=the function of a teacher; the government must do its part
7. definition=an actor's portrayal of someone in a play | synonyms=character, role, theatrical role, persona | examples=she played the part of Desdemona
8. definition=assets belonging to or due to or contributed by an individual person or group | synonyms=share, portion, percentage | examples=he wanted his share in cash
9. definition=one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division | examples=the written part of the exam; the finance section of the company
10. definition=a line of scalp that can be seen when sections of hair are combed in opposite directions | synonyms=parting | examples=his part was right in the middle
11. definition=the melody carried by a particular voice or instrument in polyphonic music | synonyms=voice | examples=he tried to sing the tenor part
12. definition=the part played by a person in bringing about a result | synonyms=contribution, share | examples=I am proud of my contribution in advancing the project; they all did their share of the work

reasoning_content:
*   Context: "For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR)."
    *   Target word: "part"
    *   Meaning in context: The "Summary of Product Characteristics" is a section or a component of a larger document called the "EPAR" (European Public Assessment Report).

    *   Sense 1: something determined in relation to something that includes it (portion, component part, constituent). Example: "feel a part of something bigger".
    *   Sense 2: something less than the whole of a human artifact (portion). Example: "rear part of the house".
    *   Sense 3: a portion of a natural object (piece). Example: "piece of granite".
    *   Sense 4: concerns a person with regard to a role/situation. Example: "vigilance on our part".
    *   Sense 5: extended spatial location (region). Example: "parts of the world".
    *   Sense 6: actions/activities assigned to a person/group (function, role). Example: "do its part".
    *   Sense 7: actor's portrayal (character, role). Example: "part of Desdemona".
    *   Sense 8: assets belonging to a person (share, portion). Example: "share in cash".
    *   Sense 9: one of the portions into which something is regarded as divided and which together constitute a whole (section, division). Example: "the written part of the exam".
    *   Sense 10: line of scalp (parting).
    *   Sense 11: melody carried by a voice/instrument (voice).
    *   Sense 12: part played by a person in bringing about a result (contribution).

    *   The "Summary of Product Characteristics" is a specific *section* or *division* of the EPAR document.
    *   Sense 1 is general ("something determined in relation to something that includes it").
    *   Sense 2 is for "human artifacts" (physical objects like a house).
    *   Sense 9 is for "portions into which something is regarded as divided and which together constitute a whole" (like a section of an exam or a company).

    *   Is a document a "human artifact" (Sense 2)? Yes, but Sense 2 examples are physical ("rear part of the house", "glue the two parts together").
    *   Is a document "regarded as divided" into sections (Sense 9)? Yes. The "Summary of Product Characteristics" is a specific section of the EPAR.
    *   Let's re-evaluate Sense 1 vs Sense 9.
        *   Sense 1: "something determined in relation to something that includes it" (component part).
        *   Sense 9: "one of the portions into which something is regarded as divided and which together constitute a whole" (section, division).
    *   In the context of a document (EPAR), the "Summary of Product Characteristics" is a distinct section. Sense 9 specifically mentions "section, division" and gives the example "the written part of the exam". This fits perfectly.

    *   Context: "Summary of Product Characteristics (also part of the EPAR)"
    *   Sense 9: "one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division | examples=the written part of the exam"
    *   This matches the usage of a section within a larger document.


[User]
Which numbered sense of "active" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. definition=exerting influence or producing a change or effect | examples=an active ingredient
7. definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. definition=(of e.g. volcanos) capable of erupting
13. definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

reasoning_content:
*   Context: "The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine..."
    *   Target word: "active"
    *   Usage: "active substance" (referring to a pharmaceutical ingredient).

    *   1: tending to become more severe (e.g., active tuberculosis) - No.
    *   2: military/naval operations (e.g., active duty) - No.
    *   3: disposed to take action/effectuate change (e.g., active interest) - No.
    *   4: taking part in an activity (e.g., active member) - No.
    *   5: energetic activity (e.g., active toddler) - No.
    *   6: exerting influence or producing a change or effect (e.g., an active ingredient) - Yes. "Active substance" is synonymous with "active ingredient" in pharmacology.
    *   7: full of activity (e.g., active seaport) - No.
    *   8: in operation (e.g., keep hope alive) - No.
    *   9: sunspots/flares - No.
    *   10: semantic function of actor (grammar) - No.
    *   11: verbs expressing action (grammar) - No.
    *   12: volcanoes capable of erupting - No.
    *   13: volcanoes erupting - No.
    *   14: full-time work - No.

    *   The phrase "active substance" in the context of a medicine (Alimta/pemetrexed) refers to the component that produces the therapeutic effect.
    *   Sense 6: "exerting influence or producing a change or effect | examples=an active ingredient".
    *   This matches perfectly.


[User]
Which numbered sense of "substance" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=the real physical matter of which a person or thing consists | examples=DNA is the substance of our genes
2. definition=the choicest or most essential or most vital part of some idea or experience | synonyms=kernel, core, center, centre, essence, gist | examples=the gist of the prosecutor's argument; the heart and soul of the Republican Party
3. definition=the idea that is intended | synonyms=meaning | examples=What is the meaning of this proverb?
4. definition=material of a particular kind or constitution | examples=the immune response recognizes invading substances
5. definition=considerable capital (wealth or income) | synonyms=means | examples=he is a man of means
6. definition=what a communication that is about something is about | synonyms=message, content, subject matter
7. definition=a particular kind or species of matter with uniform properties | examples=shigella is one of the most toxic substances known to man

reasoning_content:
*   Context: "The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine..."
    *   Target word: "substance"
    *   Contextual clues: "active substance", "pemetrexed", "cytotoxic medicine", "medicine that kills cells".

    *   Sense 1: "the real physical matter of which a person or thing consists" (e.g., DNA is the substance of our genes).
    *   Sense 2: "the choicest or most essential or most vital part of some idea or experience" (essence/gist).
    *   Sense 3: "the idea that is intended" (meaning).
    *   Sense 4: "material of a particular kind or constitution" (e.g., invading substances).
    *   Sense 5: "considerable capital (wealth or income)" (means).
    *   Sense 6: "what a communication that is about something is about" (message/content).
    *   Sense 7: "a particular kind or species of matter with uniform properties" (e.g., toxic substances).

    *   In the context of pharmacology/medicine, an "active substance" (or active ingredient) refers to the specific chemical compound that produces the intended biological effect.
    *   Sense 4 ("material of a particular kind or constitution") and Sense 7 ("a particular kind or species of matter with uniform properties") are the closest.
    *   Let's compare 4 and 7:
        *   Sense 4: "material of a particular kind or constitution" (Example: "invading substances"). This is quite general.
        *   Sense 7: "a particular kind or species of matter with uniform properties" (Example: "shigella is one of the most toxic substances known to man"). This fits the description of a chemical compound like pemetrexed perfectly.

    *   Wait, let's look at Sense 4 again: "material of a particular kind or constitution".
    *   Let's look at Sense 7 again: "a particular kind or species of matter with uniform properties".
    *   In chemistry/pharmacology, a "substance" is usually defined as a matter with a constant chemical composition and characteristic properties. This aligns best with Sense 7.
    *   Let's re-evaluate Sense 4. "Invading substances" (like antigens) are often specific chemical entities.
    *   Actually, looking at common dictionary definitions (like WordNet, which these senses seem to be derived from):
        *   Sense 4 (material of a particular kind) vs Sense 7 (particular kind or species of matter with uniform properties).
        *   Pemetrexed is a specific chemical compound. Sense 7 specifically mentions "uniform properties" and "species of matter", which is the definition of a chemical substance.

    *   Context: "The active substance in Alimta, pemetrexed..."
    *   Pemetrexed is a specific chemical.
    *   Sense 7: "a particular kind or species of matter with uniform properties".
    *   Sense 4: "material of a particular kind or constitution".
    *   Usually, "active substance" refers to the chemical entity. Sense 7 is the most precise definition for a chemical compound.

    *   Sense 1: Physical matter of a person/thing (No).
    *   Sense 2: Essence/gist (No).
    *   Sense 3: Meaning (No).
    *   Sense 4: Material of a particular kind (Possible).
    *   Sense 5: Wealth (No).
    *   Sense 6: Content of communication (No).
    *   Sense 7: Particular kind/species of matter with uniform properties (Best fit for a chemical compound).

    *   Sense 4: "the immune response recognizes invading substances" (General materials).
    *   Sense 7: "shigella is one of the most toxic substances known to man" (Specific chemical/biological entities).
    *   Pemetrexed is a specific chemical entity. Sense 7 is the most accurate.


[User]
Which numbered sense of "medicine" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

reasoning_content:
*   Context: "The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells)..."
    *   Target word: "medicine"
    *   Senses provided:
        1.  Branches of medical science (medical specialty).
        2.  Something that treats/prevents/alleviates symptoms (medication, drug).
        3.  The learned profession (practice of medicine).
        4.  Punishment for actions (metaphorical).

    *   The context refers to "Alimta" and "pemetrexed," which are described as "cytotoxic" and "kills cells that are dividing, such as cancer cells."
    *   This clearly refers to a drug or medication used for treatment.

    *   Sense 1: Medical specialty? No.
    *   Sense 2: Medication/drug? Yes.
    *   Sense 3: Profession? No.
    *   Sense 4: Punishment? No.

    *   The correct sense is 2.


[User]
Which numbered sense of "medicine" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

reasoning_content:
*   Context: "...The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells)..."
    *   Target word: "medicine" (marked with <t></t>).
    *   Senses provided:
        1.  Medical science/specialty (nonsurgical).
        2.  Something that treats/prevents/alleviates disease (medication/drug).
        3.  The profession/study of medicine.
        4.  Punishment for actions.

    *   The sentence says: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells)..."
    *   Here, "medicine" refers to "pemetrexed," which is a substance used to treat cancer.
    *   This clearly fits the definition of a medication or medicinal drug.

    *   Sense 1: Medical specialty? No.
    *   Sense 2: Medication/drug? Yes.
    *   Sense 3: Profession/study? No.
    *   Sense 4: Punishment? No.