[User]
Which numbered sense of "kill" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=cause to die; put to death, usually intentionally or knowingly | examples=This man killed several people when he tried to rob a bank; The farmer killed a pig for the holidays
2. definition=thwart the passage of | synonyms=shoot down, defeat, vote down, vote out | examples=kill a motion; he shot down the student's proposal
3. definition=end or extinguish by forceful means | synonyms=stamp out | examples=Stamp out poverty!
4. definition=be fatal | examples=cigarettes kill; drunken driving kills
5. definition=be the source of great pain for | examples=These new shoes are killing me!
6. definition=overwhelm with hilarity, pleasure, or admiration | examples=The comedian was so funny, he was killing me!
7. definition=hit with so much force as to make a return impossible, in racket games | examples=She killed the ball
8. definition=hit with great force | examples=He killed the ball
9. definition=deprive of life | examples=AIDS has killed thousands in Africa
10. definition=cause the death of, without intention | examples=She was killed in the collision of three cars
11. definition=drink down entirely | synonyms=toss off, pop, bolt down, belt down, pour down, down | examples=He downed three martinis before dinner; She killed a bottle of brandy that night
12. definition=mark for deletion, rub off, or erase | synonyms=obliterate, wipe out | examples=kill these lines in the President's speech
13. definition=tire out completely | examples=The daily stress of her work is killing her
14. definition=cause to cease operating | examples=kill the engine
15. definition=destroy a vitally essential quality of or in | examples=Eating artichokes kills the taste of all other foods

reasoning_content:
*   Context: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells)..."
    *   Target word: "kills"
    *   Meaning in context: The medicine causes the death of cells (specifically cancer cells).

    *   1. cause to die; put to death, usually intentionally or knowingly (Examples: killing people, killing a pig).
    *   2. thwart the passage of (Example: kill a motion).
    *   3. end or extinguish by forceful means (Example: stamp out poverty).
    *   4. be fatal (Example: cigarettes kill).
    *   5. be the source of great pain for (Example: shoes are killing me).
    *   6. overwhelm with hilarity, pleasure, or admiration (Example: comedian was killing me).
    *   7. hit with so much force as to make a return impossible (racket games).
    *   8. hit with great force.
    *   9. deprive of life (Example: AIDS has killed thousands).
    *   10. cause the death of, without intention (Example: killed in a collision).
    *   11. drink down entirely.
    *   12. mark for deletion, rub off, or erase.
    *   13. tire out completely.
    *   14. cause to cease operating (Example: kill the engine).
    *   15. destroy a vitally essential quality of or in.

    *   The context describes a medicine (cytotoxic) that causes cells to die.
    *   Sense 1: "cause to die; put to death, usually intentionally or knowingly". This fits well, as the medicine is designed to cause the death of the cells.
    *   Sense 4: "be fatal". This is more about the *result* (e.g., "smoking kills"), whereas the medicine *actively* causes the death of the cells.
    *   Sense 9: "deprive of life". This is very similar to Sense 1. Let's compare.
        *   Sense 1: "cause to die; put to death, usually intentionally or knowingly"
        *   Sense 9: "deprive of life"
    *   In biological/medical contexts, "killing cells" is the act of causing them to die.
    *   Looking at the examples for Sense 1: "This man killed several people... The farmer killed a pig". These are active agents causing death.
    *   Looking at the examples for Sense 9: "AIDS has killed thousands". This is a disease causing death.
    *   Wait, is there a distinction between "put to death" (Sense 1) and "deprive of life" (Sense 9)?
    *   Usually, "kill" in the sense of a drug killing bacteria or cells is the active process of causing death.
    *   Let's re-evaluate Sense 1 vs Sense 9.
        *   Sense 1: cause to die; put to death, usually intentionally or knowingly.
        *   Sense 9: deprive of life.
    *   Actually, Sense 1 is often used for agents (people, animals) and Sense 9 for diseases or general causes. However, a medicine is an agent.
    *   Let's look at the provided senses again.
    *   Sense 1: "cause to die; put to death, usually intentionally or knowingly"
    *   Sense 9: "deprive of life"
    *   In many dictionaries, "kill" meaning "to cause the death of" is the primary sense.
    *   Let's check if "deprive of life" (Sense 9) is more appropriate for biological agents like viruses or diseases.
    *   Example for Sense 9: "AIDS has killed thousands".
    *   Example for Sense 1: "This man killed several people".
    *   The medicine "kills cells". This is an active process of causing death.
    *   Is it "intentional"? The medicine is *designed* to do it.
    *   Let's look at Sense 1 again: "cause to die; put to death, usually intentionally or knowingly".
    *   Let's look at Sense 9 again: "deprive of life".
    *   Actually, in many datasets of this type (like WordNet), "kill" has several nuances.
    *   If I have to choose between 1 and 9:
        *   1: cause to die; put to death (intentional/knowing)
        *   9: deprive of life
    *   "Cytotoxic medicine (a medicine that kills cells)" -> The medicine causes the cells to die.
    *   Comparing "AIDS has killed thousands" (9) and "This man killed several people" (1).
    *   The medicine is more like the "man" (an agent acting on a target) or the "AIDS" (a biological cause)?
    *   Actually, "deprive of life" is a very general definition of killing.
    *   Let's look at the nuances again. Sense 1 mentions "intentionally or knowingly". A medicine doesn't have intentions, but the *design* of the medicine is intentional.
    *   However, "deprive of life" (Sense 9) is often used for diseases, disasters, etc.
    *   Let's search for "kill cells" in a dictionary. It's usually the basic "cause to die" sense.
    *   Between 1 and 9, 1 is "cause to die" and 9 is "deprive of life". They are almost identical.
    *   Let's re-read:
        1. cause to die; put to death, usually intentionally or knowingly
        9. deprive of life
    *   If the distinction is "intentional agent" vs "non-intentional cause", a medicine is a tool used by a doctor (intentional) but the medicine itself is a chemical (non-intentional).
    *   However, "deprive of life" is often used for things like diseases.
    *   Let's look at the examples again.
        1: "This man killed several people", "The farmer killed a pig"
        9: "AIDS has killed thousands"
    *   "Medicine kills cells" is very similar to "AIDS kills people".
    *   Wait, let me look at the senses again. Is there any other?
    *   Sense 4: "be fatal" (cigarettes kill). This is different. "Cigarettes kill" means they are fatal. "Medicine kills cells" means the medicine is the agent that causes the death.
    *   Let's compare 1 and 9 again.
        1. cause to die; put to death, usually intentionally or knowingly
        9. deprive of life
    *   In many contexts, "deprive of life" is the more general, biological sense.
    *   Let's try to see if "kill" in "kill cells" fits "deprive of life" better than "put to death".
    *   "Put to death" often implies a more formal or deliberate execution/slaughter.
    *   "Deprive of life" is a more general term for causing death.
    *   Let's look at the examples again.
        1: "This man killed several people when he tried to rob a bank; The farmer killed a pig for the holidays"
        9: "AIDS has killed thousands in Africa"
    *   "Medicine kills cells" is much closer to "AIDS kills people" than to "A man killed people during a robbery".

    *   Sense 1: Agent (person) -> Action (kill) -> Target (person/animal).
    *   Sense 9: Cause (disease) -> Action (kill) -> Target (people).
    *   Context: Agent/Cause (medicine) -> Action (kill) -> Target (cells).
    *   This fits Sense 9 better.

    *   Sense 1: "cause to die; put to death, usually intentionally or knowingly"
    *   Sense 9: "deprive of life"
    *   Wait, "cause to die" is the first part of Sense 1.
    *   Let's re-read Sense 1: "cause to die; put to death, usually intentionally or knowingly".
    *   Let's re-read Sense 9: "deprive of life".
    *   This is a very subtle difference. Let's think about "kill cells".
    *   If I say "The antibiotic kills bacteria", am I using sense 1 or 9?
    *   It's not "putting them to death" in a judicial or slaughter sense. It's "depriving them of life" (causing their death).
    *   Let's look at the examples again.
        1: Man killed people, farmer killed pig.
        9: AIDS killed thousands.
    *   The medicine is a biological/chemical agent, similar to how AIDS is a biological agent.

    *   Sense 1: cause to die; put to death, usually intentionally or knowingly.
    *   Sense 9: deprive of life.
    *   If the distinction is "intentional agent" vs "non-intentional cause", then 9 is better.
    *   If the distinction is "cause to die" (general) vs "deprive of life" (general), they are the same.
    *   But the examples provided are the key.
    *   Example 1: Man robbing bank, farmer killing pig. (Active, intentional agents)
    *   Example 9: AIDS killing people. (Biological cause)
    *   "Medicine kills cells" fits the "biological cause" pattern of Example 9.

    *   Sense 4: "be fatal" (cigarettes kill).
    *   "Cigarettes kill" means "smoking cigarettes is fatal".
    *   "Medicine kills cells" means "the medicine causes the cells to die".
    *   These are different. In "cigarettes kill", "kill" is used intransitively (or with an implied object). In "medicine kills cells", "kill" is used transitively.
    *   Wait, "cigarettes kill" can also be transitive ("cigarettes kill people"), but the sense "be fatal" is often used for the general statement.
    *   In the context "a medicine that kills cells", "kills" is definitely transitive.

    *   Sense 1: cause to die; put to death, usually intentionally or knowingly.
    *   Sense 9: deprive of life.
    *   Let's look at the examples again.
    *   1: "This man killed several people when he tried to rob a bank; The farmer killed a pig for the holidays"
    *   9: "AIDS has killed thousands in Africa"
    *   The medicine is an agent that causes death to cells. This is very similar to a disease causing death to people.

    *   Is there any other sense?
    *   15: "destroy a vitally essential quality of or in" (Eating artichokes kills the taste). No.
    *   14: "cause to cease operating" (kill the engine). No.
    *   13: "tire out completely". No.
    *   12: "mark for deletion". No.
    *   11: "drink down entirely". No.
    *   10: "cause the death of, without intention". No.
    *   The choice is really between 1 and 9.

    *   Sense 1: "cause to die; put to death, usually intentionally or knowingly"
    *   Sense 9: "deprive of life"
    *   Let's think about the word "cytotoxic". "Cyto" = cell, "toxic" = poisonous.
    *   A cytotoxic medicine is one that is poisonous to cells, causing them to die.
    *   This is a biological process.
    *   Comparing "The farmer killed a pig" (1) and "AIDS has killed thousands" (9).
    *   The medicine killing cells is much more like the disease killing people.

    *   Wait, let me double-check Sense 1 again. "cause to die; put to death, usually intentionally or knowingly".
    *   If "cause to die" is the primary definition, it could be 1.
    *   But "deprive of life" is also a primary definition.
    *   Let's look at the examples one more time.
    *   1: Man robbing bank, farmer killing pig.
    *   9: AIDS killed thousands.
    *   The most similar example to "medicine kills cells" is "AIDS killed thousands".

    *   Sense 1: cause to die; put to death, usually intentionally or knowingly.
    *   Sense 9: deprive of life.
    *   Is there any other difference?
    *   Maybe Sense 1 is for *sentient* beings and Sense 9 is for *any* life?
    *   No, Sense 1 has "a pig".
    *   Maybe Sense 1 is for *active* killing and Sense 9 is for *passive* or *disease-based* killing?
    *   "AIDS has killed thousands" (9) vs "This man killed several people" (1).
    *   A medicine is an active agent, but it's a chemical agent.
    *   Let's search for "deprive of life" in a dictionary. It's often used as a formal definition of "kill".
    *   Let's search for "cause to die". Also a formal definition.
    *   This is tough. Let's re-read the context: "a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells)".
    *   This is a scientific description.
    *   "AIDS has killed thousands" is also a factual, scientific/statistical statement.
    *   "This man killed several people" is a narrative statement about a crime.
    *   The tone of the context matches the tone of Example 9 better.

    *   Sense 1: cause to die; put to death, usually intentionally or knowingly.
    *   Sense 9: deprive of life.
    *   Wait, I just noticed something. Sense 1 says "cause to die; put to death". Sense 9 says "deprive of life".
    *   In many dictionaries, "deprive of life" is the most basic definition of "kill".
    *   Let's look at the examples again.
    *   1: Man killed people, farmer killed pig.
    *   9: AIDS killed thousands.
    *   If I have to choose the *best* fit, 9 seems more appropriate for a biological/medical context.

    *   Wait, let me think about "cause to die" (Sense 1) again.
    *   "a medicine that kills cells" = "a medicine that causes cells to die".
    *   This is exactly what Sense 1 says: "cause to die".
    *   But Sense 1 also says "put to death, usually intentionally or knowingly".
    *   Does a medicine "put cells to death"? Not really. "Put to death" usually implies a process like execution or euthanasia.
    *   Does a medicine "deprive cells of life"? Yes, in a biological sense.
    *   Let's look at Sense 9 again: "deprive of life". Example: "AIDS has killed thousands".
    *   This fits the biological context perfectly.


attempt_kind: initial

status: success

[User]
Which numbered sense of "cell" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=any small compartment | examples=the cells of a honeycomb
2. definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. definition=small room in which a monk or nun lives | synonyms=cubicle
7. definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

finish_reason: stop

role: assistant

reasoning_content:
*   Context: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells)..."
    *   Target word: "cells"
    *   Contextual clues: "cytotoxic medicine", "kills cells that are dividing", "cancer cells", "nucleotides", "DNA and RNA", "genetic material of cells".

    *   Sense 1: any small compartment (e.g., honeycomb).
    *   Sense 2: (biology) the basic structural and functional unit of all organisms.
    *   Sense 3: electric cell (chemical reaction).
    *   Sense 4: political movement unit (cadre).
    *   Sense 5: mobile phone.
    *   Sense 6: monk/nun's room.
    *   Sense 7: prisoner's room.

    *   The context is medical/biological (cancer, cytotoxic medicine, DNA, RNA).
    *   "Cells" refers to the biological units of the body.
    *   This matches Sense 2 perfectly.

currency: USD

source: unavailable


[User]
Which numbered sense of "divide" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire after World War I
2. definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven?
3. definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries
4. definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated
5. definition=make a division or separation | synonyms=separate
6. definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea

reasoning_content:
*   Context: "...a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells)..."
    *   Target word: "dividing" (from "divide").
    *   Meaning in context: In biology, cells "divide" to reproduce (mitosis/meiosis), which involves one cell splitting into two daughter cells.

    *   Sense 1: "separate into parts or portions" (split, split up, separate). Example: "divide the cake into three equal parts".
    *   Sense 2: "perform a division" (mathematical). Example: "divide 49 by seven".
    *   Sense 3: "act as a barrier between; stand between". Example: "mountain range divides the two countries".
    *   Sense 4: "come apart". Example: "two pieces... separated".
    *   Sense 5: "make a division or separation".
    *   Sense 6: "force, take, or pull apart". Example: "separated the fighting children".

    *   Cell division is the process by which a parent cell splits into two or more daughter cells.
    *   This fits best with "separate into parts or portions" (Sense 1) or "make a division or separation" (Sense 5).
    *   Looking closer at Sense 1: "separate into parts or portions | synonyms=split, split up, separate". This describes the physical act of one thing becoming multiple things.
    *   Looking at Sense 5: "make a division or separation". This is very general.
    *   Comparing Sense 1 and Sense 5: Sense 1 is more descriptive of the process of splitting one entity into parts. Cell division is essentially a cell splitting into two.

    *   Sense 1: "separate into parts or portions" (split, split up).
    *   Sense 2: Math. (No)
    *   Sense 3: Barrier. (No)
    *   Sense 4: Come apart (passive/accidental). (No)
    *   Sense 5: Make a division. (Too vague)
    *   Sense 6: Force apart. (No)

    *   In biological contexts, "dividing cells" refers to cells undergoing mitosis/meiosis, which is the process of splitting one cell into two. This aligns most closely with Sense 1 ("separate into parts or portions").

    *   Wait, let me re-read Sense 1 and Sense 5.
    *   Sense 1: "separate into parts or portions"
    *   Sense 5: "make a division or separation"
    *   Usually, in these types of NLP tasks (like WordNet), "divide" in the sense of cell division is mapped to the general sense of splitting one thing into two or more. Sense 1 is the most common general sense for this.

    *   Context: "cells that are dividing"
    *   Sense 1: "separate into parts or portions" -> "cells that are separating into parts/portions" (Correct).


[User]
Which numbered sense of "body" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Senses:
1. definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
2. definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium; the student body
3. definition=a natural object consisting of a dead animal or person | synonyms=dead body | examples=they found the body in the lake
4. definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. definition=the body excluding the head and neck and limbs | synonyms=torso, trunk | examples=they moved their arms and legs and bodies
6. definition=a collection of particulars considered as a system | examples=a body of law; a body of doctrine
7. definition=the property of holding together and retaining its shape | synonyms=consistency, consistence, eubstance | examples=wool has more body than rayon; when the dough has enough consistency it is ready to bake
8. definition=the central message of a communication | examples=the body of the message was short
9. definition=the main mass of a thing
10. definition=a resonating chamber in a musical instrument (as the body of a violin) | synonyms=soundbox
11. definition=the external structure of a vehicle | examples=the body of the car was badly rusted

reasoning_content:
*   Context: "In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes..."
    *   Target word: "body"
    *   Meaning in context: The physical structure of a human/organism where a medicine (pemetrexed) is processed.

    *   Sense 1: the entire structure of an organism (an animal, plant, or human being). (Matches)
    *   Sense 2: a group of persons associated by some common tie. (Doesn't match)
    *   Sense 3: a dead animal or person. (Doesn't match)
    *   Sense 4: an individual 3-dimensional object (e.g., heavenly body). (Doesn't match)
    *   Sense 5: the body excluding head, neck, and limbs (torso). (Doesn't match)
    *   Sense 6: a collection of particulars (e.g., body of law). (Doesn't match)
    *   Sense 7: property of holding together (consistency). (Doesn't match)
    *   Sense 8: central message of a communication. (Doesn't match)
    *   Sense 9: the main mass of a thing. (Doesn't match)
    *   Sense 10: resonating chamber in a musical instrument. (Doesn't match)
    *   Sense 11: external structure of a vehicle. (Doesn't match)

    *   The context refers to the biological process of a drug being converted into an active form within a patient's physical structure. This aligns perfectly with Sense 1.


[User]
Which numbered sense of "convert" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Senses:
1. definition=change from one system to another or to a new plan or policy | synonyms=change over | examples=We converted from 220 to 110 Volt
2. definition=change the nature, purpose, or function of something | examples=convert lead into gold; convert hotels into jails
3. definition=change religious beliefs, or adopt a religious belief | examples=She converted to Buddhism
4. definition=exchange or replace with another, usually of the same kind or category | synonyms=change, exchange, commute | examples=Could you convert my dollars into pounds?; He changed his name
5. definition=cause to adopt a new or different faith | examples=The missionaries converted the Indian population
6. definition=score an extra point or points after touchdown by kicking the ball through the uprights or advancing the ball into the end zone | examples=Smith converted and his team won
7. definition=complete successfully | examples=score a penalty shot or free throw
8. definition=score (a spare)
9. definition=make (someone) agree, understand, or realize the truth or validity of something | synonyms=win over, convince | examples=He had finally convinced several customers of the advantages of his product
10. definition=exchange a penalty for a less severe one | synonyms=commute, exchange
11. definition=change in nature, purpose, or function; undergo a chemical change | examples=The substance converts to an acid

reasoning_content:
*   Context: "In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes..."
    *   Target word: "converted"
    *   Meaning in context: Pemetrexed (a chemical substance/medicine) changes into another form (an active form) within the body. This is a chemical/biological transformation.

    *   Sense 1: Change from one system to another or to a new plan or policy (e.g., 220 to 110 Volt). -> Not applicable.
    *   Sense 2: Change the nature, purpose, or function of something (e.g., lead into gold, hotels into jails). -> Close, but usually refers to physical objects or general nature.
    *   Sense 3: Change religious beliefs. -> Not applicable.
    *   Sense 4: Exchange or replace with another (e.g., dollars into pounds). -> Not applicable.
    *   Sense 5: Cause to adopt a new faith. -> Not applicable.
    *   Sense 6: Score extra points in football. -> Not applicable.
    *   Sense 7: Complete successfully (penalty shot). -> Not applicable.
    *   Sense 8: Score a spare. -> Not applicable.
    *   Sense 9: Make someone agree/convince. -> Not applicable.
    *   Sense 10: Exchange a penalty for a less severe one. -> Not applicable.
    *   Sense 11: Change in nature, purpose, or function; undergo a chemical change (e.g., The substance converts to an acid). -> This fits perfectly. Pemetrexed is a substance undergoing a chemical change in the body.

    *   Sense 2 is "change the nature, purpose, or function of something".
    *   Sense 11 is "change in nature, purpose, or function; undergo a chemical change".
    *   The context specifically describes a drug (chemical substance) changing into an active form in the body. Sense 11 explicitly mentions "undergo a chemical change" and provides an example "The substance converts to an acid", which is almost identical in structure and meaning to "pemetrexed is converted into an active form".


[User]
Which numbered sense of "active" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Senses:
1. definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. definition=exerting influence or producing a change or effect | examples=an active ingredient
7. definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. definition=(of e.g. volcanos) capable of erupting
13. definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

reasoning_content:
*   Context: "In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes..."
    *   Target word: "active"
    *   Meaning in context: The form of the drug (pemetrexed) that is capable of producing the desired pharmacological effect (blocking enzymes).

    *   1: tending to become more severe (e.g., active tuberculosis) - No.
    *   2: military/naval operations - No.
    *   3: disposed to take action/effectuate change (e.g., active interest) - No.
    *   4: taking part in an activity (e.g., active member) - No.
    *   5: energetic activity (e.g., active toddler) - No.
    *   6: exerting influence or producing a change or effect (e.g., an active ingredient) - Yes. This fits perfectly. A drug's "active form" or "active ingredient" is the part that produces the effect.
    *   7: full of activity (e.g., active seaport) - No.
    *   8: in operation/alive - No.
    *   9: sunspots/flares - No.
    *   10: grammar (subject as actor) - No.
    *   11: grammar (verbs expressing action) - No.
    *   12: volcanoes (capable of erupting) - No.
    *   13: volcanoes (erupting) - No.
    *   14: full-time work - No.

    *   The context refers to a chemical/pharmacological substance ("active form") that "blocks the activity of the enzymes". This is exactly what "exerting influence or producing a change or effect" (Sense 6) means, especially as illustrated by the example "an active ingredient".


[User]
Which numbered sense of "form" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Senses:
1. definition=the phonological or orthographic sound or appearance of a word that can be used to describe or identify something | synonyms=word form, signifier, descriptor | examples=the inflected forms of a word can be represented by a stem and a list of inflections to be attached
2. definition=a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety | examples=sculpture is a form of art; what kinds of desserts are there?
3. definition=a perceptual structure | synonyms=shape, pattern | examples=the composition presents problems for students of musical form; a visual pattern must include not only objects but the spaces between them
4. definition=any spatial attributes (especially as defined by outline) | synonyms=shape, configuration, contour, conformation | examples=he could barely make out their shapes
5. definition=alternative names for the body of a human being | synonyms=human body, physical body, material body, soma, build, figure | examples=Leonardo studied the human body; he has a strong physique
6. definition=the spatial arrangement of something as distinct from its substance | synonyms=shape | examples=geometry is the mathematical science of shape
7. definition=the visual appearance of something or someone | synonyms=shape, cast | examples=the delicate cast of his features
8. definition=a printed document with spaces in which to write | examples=he filled out his tax form
9. definition=(biology) a group of organisms within a species that differ in trivial ways from similar groups | synonyms=variant, strain, var. | examples=a new strain of microorganisms
10. definition=an arrangement of the elements in a composition or discourse | examples=the essay was in the form of a dialogue; he first sketches the plot in outline form
11. definition=a particular mode in which something is manifested | examples=his resentment took the form of extreme hostility
12. definition=(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary | synonyms=phase | examples=the reaction occurs in the liquid phase of the system
13. definition=a body of students who are taught together | synonyms=class, grade, course | examples=early morning classes are always sleepy
14. definition=an ability to perform well | examples=he was at the top of his form; the team was off form last night
15. definition=a life-size dummy used to display clothes | synonyms=mannequin, manikin, mannikin, manakin
16. definition=a mold for setting concrete | examples=they built elaborate forms for pouring the foundation

reasoning_content:
*   Context: "In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes..."
    *   Target word: "form"
    *   Meaning in context: Pemetrexed (a drug) is converted into a different chemical state or version of itself (an active metabolite) that performs a specific function.

    *   1: Phonological/orthographic sound/appearance of a word. (Incorrect)
    *   2: A category of things distinguished by some common characteristic (kind, sort, variety). (Possible, but usually refers to broader categories like "form of art").
    *   3: Perceptual structure (shape, pattern). (Incorrect)
    *   4: Spatial attributes (shape, configuration). (Incorrect)
    *   5: Human body. (Incorrect)
    *   6: Spatial arrangement vs. substance. (Incorrect)
    *   7: Visual appearance. (Incorrect)
    *   8: Printed document. (Incorrect)
    *   9: (Biology) Group of organisms within a species (variant, strain). (Incorrect - this is about a chemical substance, not an organism).
    *   10: Arrangement of elements in composition/discourse. (Incorrect)
    *   11: A particular mode in which something is manifested. (Possible: "his resentment took the form of extreme hostility").
    *   12: (Physical chemistry) A distinct state of matter in a system; matter that is identical in chemical composition and physical state... (synonym: phase). (Close, but "active form" in pharmacology usually refers to a metabolite or a specific chemical structure/state, not necessarily a phase like liquid/gas).
    *   13: Body of students. (Incorrect)
    *   14: Ability to perform well. (Incorrect)
    *   15: Life-size dummy. (Incorrect)
    *   16: Mold for concrete. (Incorrect)

    *   Sense 2: "a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety".
    *   Sense 11: "a particular mode in which something is manifested".
    *   Sense 12: "(physical chemistry) a distinct state of matter...".

    Let's re-examine "active form" in a medical/chemical context.
    "Pemetrexed is converted into an active form..."
    This means it's converted into a specific *version* or *kind* of the molecule (the active metabolite).

    Does Sense 2 fit? "a kind, sort, or variety". "An active variety/kind of pemetrexed." Yes.
    Does Sense 11 fit? "a particular mode in which something is manifested". "An active mode in which pemetrexed is manifested." Not quite.
    Does Sense 12 fit? "a distinct state of matter... phase". No, it's not changing from liquid to gas.

    Wait, let's look at Sense 2 again. "sculpture is a form of art".
    Let's look at Sense 11 again. "his resentment took the form of extreme hostility".

    Actually, in pharmacology, "active form" often means the specific chemical structure (metabolite) that is biologically active. This is a "kind" or "variety" of the substance.

    Let's check if there's a better fit.
    Sense 2: "a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety".
    If we say "an active form of the drug", we mean "an active kind/version of the drug".

    Let's double-check Sense 11: "a particular mode in which something is manifested". This is usually used for abstract things (resentment, fear, etc.).

    Let's double-check Sense 12: "a distinct state of matter... phase". This is too specific to physical chemistry phases.

    Is there any other sense?
    Sense 9 is for organisms.

    Comparing Sense 2 and Sense 11:
    Sense 2: "a category of things... kind, sort, variety".
    Sense 11: "a particular mode in which something is manifested".

    "Active form" in this context refers to the active metabolite. A metabolite is a different chemical *kind* or *version* of the original drug.

    Let's look at other examples of Sense 2: "sculpture is a form of art".
    Let's look at other examples of Sense 11: "his resentment took the form of extreme hostility".

    Actually, "active form" is very common in science to mean a specific version or variety of a molecule.

    Let's re-read Sense 2: "a category of things distinguished by some common characteristic or quality".
    Is an active metabolite a "category of things"? Not really. It's a specific *type* or *version*.

    Wait, let's look at Sense 11 again: "a particular mode in which something is manifested".
    If the drug "manifests" as an active form... no, that's not right.

    Let's reconsider Sense 2. "Kind, sort, variety".
    "The active form of the enzyme" -> "The active kind of the enzyme". This fits reasonably well.

    Let's search for "active form" in dictionaries.
    Often, "form" in "active form" means "a particular state or type".
    Looking at the provided senses again.
    Sense 2: kind, sort, variety.
    Sense 11: particular mode in which something is manifested.

    Let's try to find a better fit.
    Is it Sense 12? "a distinct state of matter in a system; matter that is identical in chemical composition and physical state...". No, the chemical composition changes when a drug is converted to its active form (metabolized).

    Is it Sense 2? "a category of things distinguished by some common characteristic or quality".
    If we consider "active forms" as a category of the drug's states... maybe.

    Let's look at Sense 11 again. "a particular mode in which something is manifested".
    If we say "the drug exists in an active form", it's like saying "the drug manifests in an active mode".

    Let's compare:
    "The drug is converted into an active form."
    "The drug is converted into an active kind." (Sense 2)
    "The drug is converted into an active mode." (Sense 11)

    Actually, Sense 2 is often used for "a particular type of something".
    Example: "a form of energy", "a form of communication".
    "An active form of the drug" fits this pattern.

    Let's double-check Sense 2 again. "a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety".
    If "active form" means "active variety", then Sense 2 is the best fit.

    Let's check Sense 11 again. "a particular mode in which something is manifested".
    Example: "his resentment took the form of extreme hostility".
    This is more about how an abstract feeling is expressed.

    Therefore, Sense 2 seems the most plausible among the choices.

    Wait, let me look at Sense 12 again. "(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary".
    This is definitely not it because the chemical composition changes during conversion to an active metabolite.

    Let's look at Sense 9. "(biology) a group of organisms within a species that differ in trivial ways from similar groups".
    Not organisms.

    Let's look at Sense 2 one more time. "a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety".
    "Active form" = "Active variety/kind".

    Let's think if there are any other possibilities.
    Could it be Sense 11? "a particular mode in which something is manifested".
    If you say "the disease took the form of a rash", that's Sense 11.
    If you say "the drug is in an active form", is that a "mode of manifestation"? Not really.

    Let's check Sense 2 again. "sculpture is a form of art".
    "An active form of pemetrexed" -> "An active kind of pemetrexed".
    This seems the most likely.

    Wait, let me search for "active form" in a dictionary.
    Merriam-Webster: "form" (noun)
    1. a configuration...
    2. a particular way in which a thing exists or is experienced...
    (This matches Sense 11 or Sense 2).

    Let's look at the provided senses again.
    Sense 2: "a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety"
    Sense 11: "a particular mode in which something is manifested"

    If we use the "way in which a thing exists" definition, which one is closer?
    "A particular mode in which something is manifested" (Sense 11)
    "A category of things distinguished by some common characteristic" (Sense 2)

    Actually, "active form" in chemistry/pharmacology refers to the specific molecular structure.
    Is a molecular structure a "category" (Sense 2) or a "mode of manifestation" (Sense 11)?
    It's more like a "type" or "variety" (Sense 2).

    Let's re-evaluate Sense 11: "his resentment took the form of extreme hostility".
    This is about an abstract quality (resentment) taking a concrete shape (hostility).
    In "active form of pemetrexed", pemetrexed is the substance, and the "active form" is the specific version of that substance.

    Let's try Sense 2 again. "sculpture is a form of art".
    "Active form" is a "kind" of the drug.

    Let's search for "form" in the context of "active form of a drug".
    Many dictionaries list this as "a particular state or type".
    "Type" is a synonym for "kind, sort, variety" (Sense 2).

    Let's double-check Sense 11 again. "a particular mode in which something is manifested".
    If the drug "manifests" as an active form... it's possible, but Sense 2's "kind/sort/variety" feels slightly more natural for a chemical version.

    Wait, let me look at Sense 2's example: "sculpture is a form of art".
    This is "X is a type of Y".
    "The active form is a type of pemetrexed."
    This fits perfectly.

    Let's check Sense 11's example: "his resentment took the form of extreme hostility".
    This is "X manifested as Y".
    "Pemetrexed manifested as an active form."
    This is less natural.

    Final check:
    Context: "pemetrexed is converted into an active form"
    Sense 2: "a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety"
    Sense 11: "a particular mode in which something is manifested"

    Sense 2 is the most likely.


[User]
Which numbered sense of "block" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Senses:
1. definition=render unsuitable for passage | synonyms=barricade, blockade, stop, block off, block up, bar | examples=block the way; barricade the streets
2. definition=hinder or prevent the progress or accomplishment of | synonyms=obstruct, blockade, hinder, stymie, stymy, embarrass | examples=His brother blocked him at every turn
3. definition=stop from happening or developing | synonyms=stop, halt, kibosh | examples=Block his election; Halt the process
4. definition=interfere with or prevent the reception of signals | synonyms=jam | examples=Jam the Voice of America; block the signals emitted by this station
5. definition=run on a block system | examples=block trains
6. definition=interrupt the normal function of by means of anesthesia | examples=block a nerve; block a muscle
7. definition=shut out from view or get in the way so as to hide from sight | synonyms=obstruct | examples=The thick curtain blocked the action on the stage; The trees obstruct my view of the mountains
8. definition=stamp or emboss a title or design on a book with a block | examples=block the book cover
9. definition=obstruct | synonyms=stuff, lug, choke up | examples=My nose is all stuffed; Her arteries are blocked
10. definition=block passage through | synonyms=obstruct, obturate, impede, occlude, jam, close up | examples=obstruct the path
11. definition=support, secure, or raise with a block | examples=block a plate for printing; block the wheels of a car
12. definition=impede the movement of (an opponent or a ball) | synonyms=parry, deflect | examples=block an attack
13. definition=be unable to remember | synonyms=forget, blank out, draw a blank | examples=I'm drawing a blank; You are blocking the name of your first wife!
14. definition=shape by using a block | examples=Block a hat; block a garment
15. definition=shape into a block or blocks | examples=block the graphs so one can see the results clearly
16. definition=prohibit the conversion or use of (assets) | synonyms=freeze, immobilize, immobilise | examples=Blocked funds; Freeze the assets of this hostile government

reasoning_content:
*   Context: "...pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides..."
    *   Target word: "blocks"
    *   Meaning in context: The drug (pemetrexed) prevents the enzymes from functioning/working.

    *   1. render unsuitable for passage (physical barrier) - No.
    *   2. hinder or prevent the progress or accomplishment of (general hindrance) - Possible, but maybe too general.
    *   3. stop from happening or developing (stop a process/event) - Possible.
    *   4. interfere with signals (jamming) - No.
    *   5. block system (trains) - No.
    *   6. interrupt normal function by means of anesthesia - No (this is a drug, but not anesthesia).
    *   7. shut out from view - No.
    *   8. stamp/emboss - No.
    *   9. obstruct (stuff/choke up, e.g., nose/arteries) - No.
    *   10. block passage through - No.
    *   11. support/secure with a block - No.
    *   12. impede movement of opponent/ball - No.
    *   13. unable to remember - No.
    *   14. shape using a block - No.
    *   15. shape into a block - No.
    *   16. prohibit conversion/use of assets - No.

    *   Sense 2: "hinder or prevent the progress or accomplishment of"
    *   Sense 3: "stop from happening or developing"

    Wait, let me look closer at the context: "blocks the activity of the enzymes".
    In biochemistry, "blocking an enzyme" means inhibiting its activity.

    Let's re-evaluate the senses. Is there a better one?
    Sense 2: "hinder or prevent the progress or accomplishment of"
    Sense 3: "stop from happening or developing"

    Actually, looking at the provided senses again, none of them explicitly mention "biochemical inhibition". Let's see if any other sense fits better.
    Sense 2: "hinder or prevent the progress or accomplishment of" (e.g., "His brother blocked him at every turn")
    Sense 3: "stop from happening or developing" (e.g., "Block his election; Halt the process")

    If the drug blocks the *activity* of the enzymes, it is stopping that activity from happening.

    Let's check if "block" in a biological sense (like enzyme inhibition) usually maps to one of these.
    "Block the activity" $\approx$ "Stop the activity".

    Comparing Sense 2 and Sense 3:
    Sense 2 is often about progress or goals.
    Sense 3 is about stopping a process or event.

    "The activity of the enzymes" is a process.

    Let's double-check if there's any other sense.
    Sense 6: "interrupt the normal function of by means of anesthesia". This is close (interrupting function), but it specifies "by means of anesthesia". Pemetrexed is a cytotoxic medicine, not an anesthetic.

    Let's look at Sense 2 again: "hinder or prevent the progress or accomplishment of".
    Let's look at Sense 3 again: "stop from happening or developing".

    If I say "block the activity", I am stopping the activity from occurring.

    Let's search for "block the activity of enzymes" in a dictionary or thesaurus.
    Synonyms for "block" in this context: inhibit, obstruct, prevent.

    Looking at the provided options again:
    Sense 2: obstruct, blockade, hinder, stymie, stymy, embarrass.
    Sense 3: stop, halt, kibosh.

    "Stop the activity" sounds more natural than "hinder the progress of the activity" in this specific scientific context, although both are close. However, "stop from happening" (Sense 3) fits "blocking the activity" (preventing the activity from happening).

    Wait, let me re-read Sense 2: "hinder or prevent the progress or accomplishment of".
    And Sense 3: "stop from happening or developing".

    Actually, in many NLP datasets (like WordNet), "block" in the sense of inhibiting a biological process is often categorized under "prevent" or "hinder".

    Let's re-examine Sense 2 and 3.
    Sense 2: "hinder or prevent the progress or accomplishment of"
    Sense 3: "stop from happening or developing"

    If the drug blocks the activity, it prevents the activity from occurring.

    Let's look at the examples:
    Sense 2: "His brother blocked him at every turn" (preventing progress)
    Sense 3: "Block his election; Halt the process" (stopping an event/process)

    "The activity of the enzymes" is more like a process than a goal. So Sense 3 ("Halt the process") seems like a better fit than Sense 2 ("prevent the progress or accomplishment of").

    Wait, let me look at Sense 2 again. "hinder or prevent the progress...".
    If the enzyme activity is a process, Sense 3 ("stop from happening or developing") or Sense 2 ("hinder or prevent the progress") could both work.

    Let's think about "block" in "block the activity of the enzymes".
    It means the enzyme can no longer perform its function.
    This is essentially "stopping" the activity.

    Let's check if there's any other sense I missed.
    Sense 1: physical passage.
    Sense 4: signals.
    Sense 6: anesthesia.
    Sense 9: obstruct (stuff/choke up).
    Sense 10: block passage through.

    None of those fit.

    Between 2 and 3:
    Sense 2: hinder or prevent the progress or accomplishment of.
    Sense 3: stop from happening or developing.

    "Block the activity" $\rightarrow$ "Stop the activity from happening".

    Let's try to see if "block" in this context is more about "preventing" (Sense 2) or "stopping" (Sense 3).
    In medical contexts, "blocking a receptor" or "blocking an enzyme" means preventing it from functioning.

    Let's look at the examples for Sense 3 again: "Block his election; Halt the process".
    "Halt the process" is very similar to "block the activity of the enzymes".

    Let's look at Sense 2 again: "His brother blocked him at every turn". This is more about obstruction of a person's goals.

    Therefore, Sense 3 seems more appropriate.

    Wait, let me search for this specific sense mapping in common datasets (like WordNet).
    In WordNet, "block" (verb) has several senses:
    1. obstruct (physical)
    2. hinder (prevent progress)
    3. stop (prevent from happening)

    If we look at the provided senses:
    Sense 2: hinder or prevent the progress or accomplishment of.
    Sense 3: stop from happening or developing.

    "Block the activity of the enzymes" = "Stop the activity of the enzymes".

    Let's double-check Sense 2 again. "hinder or prevent the progress or accomplishment of".
    If the activity is seen as a "progress", then 2. But "activity" is more of a "process" or "event".

    Let's re-read: "blocks the activity of the enzymes that are involved in producing nucleotides".
    This means the production of nucleotides is stopped because the enzyme activity is blocked.

    Sense 3: "stop from happening or developing" (Example: "Halt the process").
    This fits perfectly. The "process" is the activity of the enzymes.

    Let's quickly check Sense 2 again. "hinder or prevent the progress or accomplishment of".
    This is often used for goals or ambitions.

    Final check:
    Context: "blocks the activity of the enzymes"
    Sense 3: "stop from happening or developing" (Synonyms: stop, halt)
    Sense 2: "hinder or prevent the progress or accomplishment of" (Synonyms: obstruct, hinder)

    "Stop the activity" is a very common way to describe enzyme inhibition.

    Wait, let me look at Sense 2's synonyms: "obstruct, blockade, hinder, stymie, stymy, embarrass".
    And Sense 3's synonyms: "stop, halt, kibosh".

    In biochemistry, "block" is often used as a synonym for "inhibit".
    "Inhibit" can mean "hinder, prevent, or restrain".

    Let's re-evaluate Sense 2 vs Sense 3 one more time.
    Sense 2: "hinder or prevent the progress or accomplishment of"
    Sense 3: "stop from happening or developing"

    If the drug *completely* blocks the enzyme, it stops the activity. If it *partially* blocks it, it hinders it. "Blocks the activity" usually implies a more complete stop or a general prevention.

    Let's look at the examples again.
    Sense 3: "Halt the process".
    The activity of enzymes is a biological process.

    Sense 2: "His brother blocked him at every turn".
    This is about a person's progress.

    Sense 3 seems the most fitting.


[User]
Which numbered sense of "involved" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Senses:
1. definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved; the problems involved
2. definition=entangled or hindered as if e.g. in mire | synonyms=mired | examples=the difficulties in which the question is involved; brilliant leadership mired in details and confusion
3. definition=emotionally involved
4. definition=highly complex or intricate and occasionally devious; ; ; ; ; ; ; ; - Sir Walter Scott | synonyms=Byzantine, convoluted, knotty, tangled, tortuous | examples=the Byzantine tax structure; Byzantine methods for holding on to his chairmanship
5. definition=enveloped | examples=a castle involved in mist; the difficulties in which the question is involved

reasoning_content:
*   Context: "...pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides..."
    *   Target word: "involved"
    *   Meaning in context: The enzymes that *participate* in or are *part of* the process of producing nucleotides.

    *   Sense 1: "connected by participation or association or use" (Example: "the problems involved"). This fits well. The enzymes participate in the process.
    *   Sense 2: "entangled or hindered as if e.g. in mire" (Example: "mired in details"). This does not fit.
    *   Sense 3: "emotionally involved". This does not fit (enzymes don't have emotions).
    *   Sense 4: "highly complex or intricate" (Example: "Byzantine tax structure"). This does not fit.
    *   Sense 5: "enveloped" (Example: "castle involved in mist"). This does not fit.

    *   The enzymes are "connected by participation" in the production of nucleotides. This matches Sense 1.


[User]
Which numbered sense of "produce" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in <t>producing</t> nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Senses:
1. definition=bring forth or yield | synonyms=bring forth | examples=The tree would not produce fruit
2. definition=create or manufacture a man-made product | synonyms=make, create | examples=We produce more cars than we can sell; The company has been making toys for two centuries
3. definition=cause to happen, occur or exist | synonyms=bring about, give rise | examples=This procedure produces a curious effect; The new law gave rise to many complaints
4. definition=bring out for display | synonyms=bring forth | examples=The proud father produced many pictures of his baby; The accused brought forth a letter in court that he claims exonerates him
5. definition=cultivate by growing, often involving improvements by means of agricultural techniques | synonyms=grow, raise, farm | examples=The Bordeaux region produces great red wines; They produce good ham in Parma
6. definition=bring onto the market or release | synonyms=bring on, bring out | examples=produce a movie; bring out a book
7. definition=come to have or undergo a change of (physical features and attributes) | synonyms=grow, develop, get, acquire | examples=He grew a beard; The patient developed abdominal pains

reasoning_content:
*   Context: "...enzymes that are involved in <t>producing</t> nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."
    *   Target word: "producing" (from "produce").
    *   Meaning in context: The enzymes are responsible for the synthesis/creation of nucleotides within the body.

    *   Sense 1: bring forth or yield (e.g., tree producing fruit).
    *   Sense 2: create or manufacture a man-made product (e.g., producing cars).
    *   Sense 3: cause to happen, occur or exist (e.g., procedure produces an effect).
    *   Sense 4: bring out for display (e.g., produced pictures of baby).
    *   Sense 5: cultivate by growing (e.g., region produces wines).
    *   Sense 6: bring onto the market or release (e.g., produce a movie).
    *   Sense 7: come to have or undergo a change of (e.g., grew a beard).

    *   The context is biological synthesis (enzymes creating nucleotides).
    *   Sense 1 ("bring forth or yield") is often used for biological production (like fruit), but nucleotides aren't "yielded" like fruit; they are synthesized. However, "bring forth" can be broad.
    *   Sense 2 ("create or manufacture a man-made product") is specifically for *man-made* products. Nucleotides are natural.
    *   Sense 3 ("cause to happen, occur or exist") is more about effects or events.
    *   Sense 4, 5, 6, 7 are clearly incorrect.

    *Wait, let me re-evaluate Sense 1 and Sense 3.*
    *   Sense 1: "bring forth or yield". Example: "The tree would not produce fruit". This is biological production.
    *   Sense 3: "cause to happen, occur or exist". Example: "This procedure produces a curious effect".

    Is there a better fit? Let's look at the biological process. Enzymes *synthesize* nucleotides. Synthesis is a form of production.
    In many dictionaries, "produce" in a biological sense (like a cell producing a protein or an enzyme producing a molecule) falls under "bring forth" or "yield" (Sense 1) or "create/make" (Sense 2, though Sense 2 here specifies "man-made").

    Let's look at Sense 1 again: "bring forth or yield".
    Let's look at Sense 3 again: "cause to happen, occur or exist".

    Actually, looking at the provided senses, Sense 1 is the closest for biological production (like a tree producing fruit or a cell producing a protein).

    Let's double-check if "produce" in "producing nucleotides" fits Sense 3. "Cause nucleotides to happen/occur/exist"? Not quite.

    Let's re-examine Sense 2: "create or manufacture a man-made product". The "man-made" part makes it a poor fit.

    Let's re-examine Sense 1: "bring forth or yield". This is the standard sense for biological production.

    *Self-Correction:* Is there any other sense?
    Sense 1: bring forth or yield.
    Sense 2: create or manufacture (man-made).
    Sense 3: cause to happen.

    In biological contexts, "produce" (as in "the body produces insulin" or "enzymes produce nucleotides") is typically categorized as "bringing forth" or "yielding" a substance.

    Sense 1: "The tree would not produce fruit" -> Biological production.
    Context: "enzymes that are involved in producing nucleotides" -> Biological production.

    This matches.


[User]
Which numbered sense of "building_block" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the <t>building blocks</t> of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Senses:
1. definition=a single undivided natural thing occurring in the composition of something else | synonyms=unit | examples=units of nucleic acids
2. definition=a block of material used in construction work

reasoning_content:
*   Context: "...pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the <t>building blocks</t> of DNA and RNA, the genetic material of cells)."
    *   Target word: "building blocks"
    *   Senses:
        1.  A single undivided natural thing occurring in the composition of something else (synonym: unit; example: units of nucleic acids).
        2.  A block of material used in construction work.

    *   The context refers to "nucleotides" as the "building blocks of DNA and RNA".
    *   DNA and RNA are biological molecules.
    *   Nucleotides are the chemical units that make up these molecules.
    *   This is a biological/chemical context, not a construction/architecture context.

    *   Sense 1: "a single undivided natural thing occurring in the composition of something else" (Example: units of nucleic acids). This matches perfectly.
    *   Sense 2: "a block of material used in construction work". This does not match.

Sense 1 is the correct one.


[User]
Which numbered sense of "genetic" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the <t>genetic</t> material of cells). How has Alimta been studied?

Senses:
1. definition=occurring among members of a family usually by heredity | synonyms=familial, hereditary, inherited, transmitted, transmissible | examples=an inherited disease; familial traits
2. definition=of or relating to or produced by or being a gene | synonyms=genic, genetical | examples=genic combinations; genetic code
3. definition=pertaining to or referring to origin | examples=genetic history reconstructs the origins of a literary work
4. definition=of or relating to the science of genetics | synonyms=genetical | examples=genetic research

reasoning_content:
*   Context: "...nucleotides (the building blocks of DNA and RNA, the <t>genetic</t> material of cells)."
    *   Target word: "genetic"
    *   Senses provided:
        1.  Heredity/familial (e.g., inherited disease).
        2.  Relating to or produced by genes (e.g., genetic code).
        3.  Relating to origin (e.g., genetic history of a literary work).
        4.  Relating to the science of genetics (e.g., genetic research).

    *   The phrase is "the genetic material of cells," referring to DNA and RNA.
    *   DNA and RNA are the physical substances that make up genes and carry genetic information.
    *   Sense 1 (heredity) is about the *transmission* of traits.
    *   Sense 2 (relating to or produced by a gene) fits well because DNA/RNA *are* the material that constitutes genes.
    *   Sense 3 (origin) is about the history/derivation of something.
    *   Sense 4 (science of genetics) is about the *study* of genes.

    *   "Genetic material" is a standard term referring to the DNA/RNA that carries the instructions for an organism. This relates directly to the nature of genes (Sense 2).

    *   Sense 1: No, it's not talking about inheritance between family members here.
    *   Sense 2: Yes, DNA/RNA are the material of genes.
    *   Sense 3: No, it's not talking about the origin of a literary work or similar.
    *   Sense 4: No, it's not talking about the field of study (genetics).


[User]
Which numbered sense of "material" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic <t>material</t> of cells). How has Alimta been studied?

Senses:
1. definition=the tangible substance that goes into the makeup of a physical object | synonyms=stuff | examples=coal is a hard black material; wheat is the stuff they use to make bread
2. definition=information (data or ideas or observations) that can be used or reworked into a finished form | examples=the archives provided rich material for a definitive biography
3. definition=artifact made by weaving or felting or knitting or crocheting natural or synthetic fibers | synonyms=fabric, cloth, textile | examples=the fabric in the curtains was light and semitransparent; woven cloth originated in Mesopotamia around 5000 BC
4. definition=things needed for doing or making something | examples=writing materials; useful teaching materials
5. definition=a person judged suitable for admission or employment | examples=he was university material; she was vice-presidential material

reasoning_content:
*   Context: "...nucleotides (the building blocks of DNA and RNA, the genetic <t>material</t> of cells)."
    *   Target word: "material"
    *   Contextual meaning: DNA and RNA are described as the "genetic material" of cells.

    *   Sense 1: "the tangible substance that goes into the makeup of a physical object" (e.g., coal, wheat).
    *   Sense 2: "information (data or ideas or observations) that can be used or reworked into a finished form" (e.g., archives for a biography).
    *   Sense 3: "artifact made by weaving or felting or knitting or crocheting natural or synthetic fibers" (e.g., fabric, cloth).
    *   Sense 4: "things needed for doing or making something" (e.g., writing materials).
    *   Sense 5: "a person judged suitable for admission or employment" (e.g., university material).

    *   DNA and RNA are physical substances (molecules) that make up the genetic information of a cell.
    *   While "genetic material" refers to information, in a biological context, it refers to the physical substance (nucleic acids) that carries that information.
    *   Comparing with Sense 1: "the tangible substance that goes into the makeup of a physical object". DNA/RNA are the tangible substances that make up the genetic component of the cell.
    *   Comparing with Sense 2: "information (data or ideas or observations)". While DNA *is* information, "genetic material" usually refers to the physical molecules themselves. However, let's look closer.
    *   Wait, is "genetic material" more like "stuff" (Sense 1) or "information" (Sense 2)?
    *   In biology, "genetic material" refers to the DNA/RNA molecules. These are physical substances.
    *   Let's re-evaluate Sense 1: "the tangible substance that goes into the makeup of a physical object".
    *   Let's re-evaluate Sense 2: "information (data or ideas or observations) that can be used or reworked into a finished form". This usually refers to source material for a book or research.
    *   Sense 1 fits best because DNA/RNA are the physical substances (the "stuff") that constitute the genetic part of the cell.

    *   "Genetic material" is a standard term for the DNA or RNA of an organism.
    *   Is it "information" (Sense 2)? No, not in the sense of "data for a biography".
    *   Is it "fabric" (Sense 3)? No.
    *   Is it "supplies" (Sense 4)? No.
    *   Is it "suitability" (Sense 5)? No.
    *   Is it "tangible substance" (Sense 1)? Yes. DNA and RNA are the physical substances.

    *   Sense 1: tangible substance.
    *   Context: "genetic material of cells" (referring to DNA and RNA).
    *   Conclusion: Sense 1.


[User]
Which numbered sense of "cell" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of <t>cells</t>). How has Alimta been studied?

Senses:
1. definition=any small compartment | examples=the cells of a honeycomb
2. definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. definition=small room in which a monk or nun lives | synonyms=cubicle
7. definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

reasoning_content:
*   Context: A medical description of the drug Alimta (pemetrexed). It mentions "cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells)" and "the genetic material of <t>cells</t>".
    *   Target word: "cells" (plural of "cell").
    *   Senses provided:
        1.  Small compartment (e.g., honeycomb).
        2.  (Biology) Basic structural and functional unit of all organisms.
        3.  Electric cell.
        4.  Political movement unit (cadre).
        5.  Mobile phone.
        6.  Monk/nun's room.
        7.  Prison cell.

    *   The context discusses "blood counts", "cytotoxic medicine", "cancer cells", "DNA and RNA", and "genetic material".
    *   This is clearly a biological context referring to the basic units of life.

    *   Sense 2: "(biology) the basic structural and functional unit of all organisms..." matches perfectly.


[User]
Which numbered sense of "study" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been <t>studied</t>? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before.

Senses:
1. definition=consider in detail and subject to an analysis in order to discover essential features or meaning | synonyms=analyze, analyse, examine, canvass, canvas | examples=analyze a sonnet by Shakespeare; analyze the evidence in a criminal trial
2. definition=be a student; follow a course of study; be enrolled at an institute of learning
3. definition=give careful consideration to | synonyms=consider | examples=consider the possibility of moving
4. definition=be a student of a certain subject | synonyms=learn, read, take | examples=She is reading for the bar exam
5. definition=learn by reading books | synonyms=hit the books | examples=He is studying geology in his room; I have an exam next week; I must hit the books now
6. definition=think intently and at length, as for spiritual purposes | synonyms=meditate, contemplate | examples=He is meditating in his study

reasoning_content:
*   Context: "How has Alimta been <t>studied</t>? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients..."
    *   Target word: "studied" (past participle of "study").
    *   Meaning in context: The drug Alimta was tested/analyzed/examined in a clinical trial (a "study") to see its effects on patients.

    *   Sense 1: "consider in detail and subject to an analysis in order to discover essential features or meaning" (Synonyms: analyze, examine).
    *   Sense 2: "be a student; follow a course of study; be enrolled at an institute of learning".
    *   Sense 3: "give careful consideration to" (Synonyms: consider).
    *   Sense 4: "be a student of a certain subject" (Synonyms: learn, read, take).
    *   Sense 5: "learn by reading books" (Synonyms: hit the books).
    *   Sense 6: "think intently and at length, as for spiritual purposes" (Synonyms: meditate, contemplate).

    *   The context refers to a clinical trial ("one main study in 456 patients").
    *   In this context, "studied" means the drug was analyzed or examined through scientific research to determine its efficacy and safety.
    *   Sense 1 ("consider in detail and subject to an analysis in order to discover essential features or meaning") fits perfectly.
    *   Senses 2, 4, and 5 relate to academic learning/being a student.
    *   Sense 3 relates to thinking about a possibility.
    *   Sense 6 relates to meditation.

Sense 1 is the correct match.


[User]
Which numbered sense of "treatment" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the <t>treatment</t> of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Senses:
1. definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) | synonyms=intervention
2. definition=the management of someone or something | synonyms=handling | examples=the handling of prisoners; the treatment of water sewage
3. definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture
4. definition=an extended communication (often interactive) dealing with some particular topic | synonyms=discussion, discourse | examples=the book contains an excellent discussion of modal logic; his treatment of the race question is badly biased

reasoning_content:
*   Context: "For the <t>treatment</t> of malignant pleural mesothelioma, Alimta has been studied..."
    *   Target word: "treatment"
    *   Contextual clues: "malignant pleural mesothelioma" (a type of cancer), "Alimta" (a medicine/cytotoxic medicine), "studied in one main study in 456 patients", "chemotherapy", "cisplatin".

    *   Sense 1: Care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury). Synonyms: intervention.
    *   Sense 2: The management of someone or something. Synonyms: handling. Examples: handling of prisoners, treatment of water sewage.
    *   Sense 3: A manner of dealing with something artistically. Examples: treatment of space in architecture.
    *   Sense 4: An extended communication dealing with some particular topic. Synonyms: discussion, discourse.

    *   The context is clearly medical. It discusses a drug (Alimta) used for a disease (malignant pleural mesothelioma).
    *   "Treatment" here refers to the medical application of the drug to relieve or cure the illness.
    *   This matches Sense 1 perfectly.


[User]
Which numbered sense of "study" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been <t>studied</t> in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Senses:
1. definition=consider in detail and subject to an analysis in order to discover essential features or meaning | synonyms=analyze, analyse, examine, canvass, canvas | examples=analyze a sonnet by Shakespeare; analyze the evidence in a criminal trial
2. definition=be a student; follow a course of study; be enrolled at an institute of learning
3. definition=give careful consideration to | synonyms=consider | examples=consider the possibility of moving
4. definition=be a student of a certain subject | synonyms=learn, read, take | examples=She is reading for the bar exam
5. definition=learn by reading books | synonyms=hit the books | examples=He is studying geology in his room; I have an exam next week; I must hit the books now
6. definition=think intently and at length, as for spiritual purposes | synonyms=meditate, contemplate | examples=He is meditating in his study

reasoning_content:
*   Context: "How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been <t>studied</t> in one main study in 456 patients..."
    *   Target word: "studied" (past participle of "study").
    *   Meaning in context: The drug Alimta was tested/analyzed/examined in a clinical trial (a "study") involving 456 patients to see its effects.

    *   Sense 1: "consider in detail and subject to an analysis in order to discover essential features or meaning" (synonyms: analyze, examine).
    *   Sense 2: "be a student; follow a course of study; be enrolled at an institute of learning".
    *   Sense 3: "give careful consideration to" (synonyms: consider).
    *   Sense 4: "be a student of a certain subject" (synonyms: learn, read, take).
    *   Sense 5: "learn by reading books" (synonyms: hit the books).
    *   Sense 6: "think intently and at length, as for spiritual purposes" (synonyms: meditate, contemplate).

    *   The context describes a clinical trial. A clinical trial is a systematic analysis/examination of a drug's efficacy and safety.
    *   Sense 1 (analyze, examine) fits perfectly.
    *   Senses 2, 4, and 5 relate to academic learning/being a student.
    *   Sense 3 is more about pondering or considering an option.
    *   Sense 6 is about meditation.

    *   The word "studied" in "Alimta has been studied in one main study" means it was analyzed or examined through research. This aligns with Sense 1.


[User]
Which numbered sense of "main" (marked with <t></t>) is used in the context below? Return only the number of the correct sense.

Context: For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one <t>main</t> study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Senses:
1. definition=most important element | synonyms=chief, primary, principal, master | examples=the chief aim of living; the main doors were of solid glass
2. definition=(of a clause) capable of standing syntactically alone as a complete sentence | synonyms=independent | examples=the main (or independent) clause in a complex sentence has at least a subject and a verb
3. definition=of force; of the greatest possible intensity | examples=by main strength

reasoning_content:
*   Context: "For the treatment of malignant pleural mesothelioma, Alimta has been studied in one <t>main</t> study in 456 patients..."
    *   Target word: "main"
    *   Senses provided:
        1.  most important element (chief, primary, principal, master)
        2.  (of a clause) capable of standing syntactically alone (independent)
        3.  of force; of the greatest possible intensity

    *   The sentence says "one main study".
    *   In this context, "main study" refers to the primary or most significant study conducted for the treatment of malignant pleural mesothelioma.
    *   It doesn't refer to a grammatical clause (Sense 2).
    *   It doesn't refer to physical force or intensity (Sense 3).
    *   It fits the definition of "most important element" or "primary/principal".

    *   Sense 1: most important element / chief / primary / principal. (Matches)