[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: information
Target surface form: information
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more <t>information</t>, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=information%1:10:00:: | definition=a message received and understood | synonyms=info
2. sense_key=information%1:09:00:: | definition=knowledge acquired through study or experience or instruction
3. sense_key=information%1:10:02:: | definition=formal accusation of a crime
4. sense_key=information%1:14:00:: | definition=a collection of facts from which conclusions may be drawn | synonyms=data | examples=statistical data
5. sense_key=information%1:07:00:: | definition=(communication theory) a numerical measure of the uncertainty of an outcome | synonyms=selective information, entropy | examples=the signal contained thousands of bits of information

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
*   Target lemma: `information`
    *   Context: "For more <t>information</t>, see the Summary of Product Characteristics (also part of the EPAR)."
    *   Candidate senses:
        1.  `information%1:10:00::`: a message received and understood (info)
        2.  `information%1:09:00::`: knowledge acquired through study or experience or instruction
        3.  `information%1:10:02::`: formal accusation of a crime
        4.  `information%1:14:00::`: a collection of facts from which conclusions may be drawn (data)
        5.  `information%1:07:00::`: (communication theory) a numerical measure of the uncertainty of an outcome (entropy)

    *   The sentence "For more information, see the Summary of Product Characteristics" is a standard phrase used in documents to direct the reader to a source of knowledge or facts about a product (in this case, a medication called Alimta).
    *   It refers to the general knowledge or facts available about the drug.

    *   Sense 1 (message received): Too specific to a single act of communication.
    *   Sense 2 (knowledge acquired): This fits well. "Information" here refers to the knowledge one can acquire by reading the Summary of Product Characteristics.
    *   Sense 3 (accusation): Completely irrelevant.
    *   Sense 4 (collection of facts/data): While "information" can be "data," the context "For more information" usually refers to general knowledge/details rather than a dataset for drawing conclusions (like statistical data).
    *   Sense 5 (communication theory): Completely irrelevant.

    *   Sense 2: "knowledge acquired through study or experience or instruction". Reading a product summary is a form of instruction/study to acquire knowledge.
    *   Sense 4: "a collection of facts from which conclusions may be drawn". While a product summary contains facts, the phrase "For more information" is the idiomatic way to say "To learn more" or "For more knowledge".

    *   In most WSD datasets (like SemCor), "information" in the sense of "further details" or "knowledge" is mapped to the general "knowledge" sense.
    *   Comparing Sense 2 and Sense 4: Sense 4 is specifically about "data" (statistical data). Sense 2 is broader knowledge. "For more information" is a request for more knowledge/details.

    *   Sense 2 is the best fit.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: see
Target surface form: see
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=see%2:39:00:: | definition=perceive by sight or have the power to perceive by sight | examples=You have to be a good observer to see all the details; Can you see the bird in that tree?
2. sense_key=see%2:31:01:: | definition=perceive (an idea or situation) mentally | synonyms=understand, realize, realise | examples=Now I see!; I just can't see your point
3. sense_key=see%2:39:02:: | definition=perceive or be contemporaneous with | synonyms=witness, find | examples=We found Republicans winning the offices; You'll see a lot of cheating in this school
4. sense_key=see%2:36:00:: | definition=imagine; conceive of; see in one's mind | synonyms=visualize, visualise, envision, project, fancy, figure | examples=I can't see him on horseback!; I can see what will happen
5. sense_key=see%2:31:00:: | definition=deem to be | synonyms=consider, reckon, view, regard | examples=She views this quite differently from me; I consider her to be shallow
6. sense_key=see%2:31:02:: | definition=get to know or become aware of, usually accidentally | synonyms=learn, hear, get word, get wind, pick up, find out | examples=I learned that she has two grown-up children; I see that you have been promoted
7. sense_key=see%2:39:03:: | definition=see or watch | synonyms=watch, view, catch, take in | examples=view a show on television; This program will be seen all over the world
8. sense_key=see%2:38:00:: | definition=come together | synonyms=meet, run into, encounter, run across, come across | examples=I'll probably see you at the meeting; How nice to see you again!
9. sense_key=see%2:32:00:: | definition=find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, find out, ascertain, watch, learn | examples=I want to see whether she speaks French; See whether it works
10. sense_key=see%2:31:03:: | definition=be careful or certain to do something; make certain of something | synonyms=check, insure, see to it, ensure, control, ascertain | examples=He verified that the valves were closed; See that the curtains are closed
11. sense_key=see%2:41:11:: | definition=go to see for professional or business reasons | examples=You should see a lawyer; We had to see a psychiatrist
12. sense_key=see%2:41:12:: | definition=go to see for a social visit | examples=I went to see my friend Mary the other day
13. sense_key=see%2:41:10:: | definition=go to see a place, as for entertainment | synonyms=visit | examples=We went to see the Eiffel Tower in the morning
14. sense_key=see%2:41:14:: | definition=take charge of or deal with | synonyms=attend, take care, look | examples=Could you see about lunch?; I must attend to this matter
15. sense_key=see%2:35:09:: | definition=receive as a specified guest | examples=the doctor will see you now; The minister doesn't see anybody before noon
16. sense_key=see%2:41:00:: | definition=date regularly; have a steady relationship with | synonyms=go steady, go out, date | examples=Did you know that she is seeing an older man?; He is dating his former wife again!
17. sense_key=see%2:39:05:: | definition=see and understand, have a good eye | examples=The artist must first learn to see
18. sense_key=see%2:31:08:: | definition=deliberate or decide | examples=See whether you can come tomorrow; let's see--which movie should we see tonight?
19. sense_key=see%2:39:11:: | definition=observe as if with an eye | examples=The camera saw the burglary and recorded it
20. sense_key=see%2:39:13:: | definition=observe, check out, and look over carefully or inspect | synonyms=examine | examples=The customs agent examined the baggage; I must see your passport before you can enter the country
21. sense_key=see%2:39:12:: | definition=go or live through | synonyms=experience, go through | examples=We had many trials to go through; he saw action in Viet Nam
22. sense_key=see%2:38:03:: | definition=accompany or escort | synonyms=escort | examples=I'll see you to the door
23. sense_key=see%2:33:00:: | definition=match or meet | examples=I saw the bet of one of my fellow players
24. sense_key=see%2:31:13:: | definition=make sense of; assign a meaning to | synonyms=interpret, construe | examples=What message do you see in this letter?; How do you interpret his behavior?

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 9}
```

finish_reason: stop

content:
```json
{"sense_index": 9}
```

role: assistant

reasoning_content:
*   Target lemma: `see`
    *   Target surface form: `see`
    *   Context: "For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR)."
    *   Meaning: In this context, "see" is used as an imperative directing the reader to refer to or consult another document for more information.

    *   1: perceive by sight (too literal)
    *   2: perceive mentally (understand)
    *   3: perceive or be contemporaneous with (witness)
    *   4: imagine/conceive
    *   5: deem to be (consider)
    *   6: get to know/become aware of (learn)
    *   7: see or watch (view a show)
    *   8: come together (meet)
    *   9: find out, learn, or determine with certainty, usually by making an inquiry or other effort (determine, check, find out, ascertain)
    *   10: be careful or certain to do something (ensure)
    *   11: go to see for professional reasons
    *   12: go to see for a social visit
    *   13: go to see a place (visit)
    *   14: take charge of or deal with
    *   15: receive as a guest
    *   16: date regularly
    *   17: see and understand (artistic eye)
    *   18: deliberate or decide
    *   19: observe as if with an eye (camera)
    *   20: observe, check out, and look over carefully or inspect (examine)
    *   21: go or live through (experience)
    *   22: accompany or escort
    *   23: match or meet (bet)
    *   24: make sense of (interpret)

    *   The phrase "For more information, see [document]" is a standard way of saying "refer to [document]" or "consult [document]".
    *   Looking at the candidate senses again, none of them explicitly say "refer to a text".
    *   Let's re-examine Sense 9: "find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, find out, ascertain, watch, learn | examples=I want to see whether she speaks French; See whether it works".
    *   Let's re-examine Sense 20: "observe, check out, and look over carefully or inspect | synonyms=examine | examples=The customs agent examined the baggage; I must see your passport before you can enter the country".
    *   Let's re-examine Sense 7: "see or watch | synonyms=watch, view, catch, take in | examples=view a show on television".
    *   Let's re-examine Sense 1: "perceive by sight".

    *Wait*, let me look closer at the senses provided. Is there a "refer to" sense?
    Looking through the list again...
    1. perceive by sight
    2. perceive mentally
    3. perceive/contemporaneous
    4. imagine
    5. deem
    6. get to know
    7. see or watch
    8. come together
    9. find out, learn, or determine (check)
    10. be careful/certain
    11. professional visit
    12. social visit
    13. visit place
    14. take charge
    15. receive guest
    16. date
    17. see and understand
    18. deliberate
    19. observe (camera)
    20. observe/inspect (examine)
    21. experience
    22. escort
    23. match
    24. interpret

    None of these are a perfect match for "refer to a document". However, in many WordNet-based datasets, "see" in the sense of "refer to" is often mapped to a sense involving "looking at" or "checking".

    Let's compare Sense 9 ("find out, learn, or determine... check") and Sense 20 ("observe, check out, and look over carefully or inspect").
    "For more information, see the Summary..." means "To find more information, check the Summary...". This aligns well with Sense 9 ("find out, learn, or determine... check").

    Let's double-check Sense 1 ("perceive by sight"). While you do use your eyes to read, "see" in "see the Summary" is more about the act of referring to it to gain information.

    Let's look at Sense 9 again: "find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, find out, ascertain, watch, learn".
    Example: "See whether it works".
    This fits the "refer to for information" usage better than the others.

    Wait, let me search for "see" in WordNet for "refer to".
    In some versions of WordNet, "see" (refer to) is a separate sense. If it's not here, I must pick the closest one.
    Sense 9: "find out, learn, or determine... check".
    Sense 20: "observe, check out, and look over carefully or inspect".

    If I say "See page 10", I am telling you to *check* page 10 to *find out* the information. This matches Sense 9.

    Let's re-read Sense 9: "find out, learn, or determine with certainty, usually by making an inquiry or other effort". Referring to a document is an "effort" to "find out" or "learn" information.

    Let's re-read Sense 20: "observe, check out, and look over carefully or inspect". This is more like an inspection (like a passport).

    Sense 9 seems the most plausible fit among the choices provided.

    *   Sense 1: Too simple.
    *   Sense 2: Mental understanding.
    *   Sense 6: Accidental learning.
    *   Sense 7: Watching a show.
    *   Sense 9: Checking/finding out. (Strongest candidate)
    *   Sense 20: Inspecting.

    "For more information, see the Summary..." -> "For more information, check the Summary..." -> Sense 9.

currency: USD

source: unavailable


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: product
Target surface form: Product
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=product%1:06:01:: | definition=commodities offered for sale | synonyms=merchandise, ware | examples=good business depends on having good merchandise; that store offers a variety of products
2. sense_key=product%1:06:00:: | definition=an artifact that has been created by someone or some process | synonyms=production | examples=they improve their product every year; they export most of their agricultural production
3. sense_key=product%1:09:00:: | definition=a quantity obtained by multiplication | synonyms=mathematical product | examples=the product of 2 and 3 is 6
4. sense_key=product%1:27:00:: | definition=a chemical substance formed as a result of a chemical reaction | examples=a product of lime and nitric acid
5. sense_key=product%1:19:00:: | definition=a consequence of someone's efforts or of a particular set of circumstances | examples=skill is the product of hours of practice; his reaction was the product of hunger and fatigue
6. sense_key=product%1:14:00:: | definition=the set of elements common to two or more sets | synonyms=intersection, Cartesian product | examples=the set of red hats is the intersection of the set of hats and the set of red things

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: `product`
    *   Target surface form: `Product`
    *   Context: "For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR)."
    *   Surrounding context: The text discusses a medication called Alimta, its administration, side effects, and regulatory documents (EPAR - European Public Assessment Report).

    *   Sense 1: commodities offered for sale (merchandise, ware).
    *   Sense 2: an artifact that has been created by someone or some process (production).
    *   Sense 3: a quantity obtained by multiplication (mathematical product).
    *   Sense 4: a chemical substance formed as a result of a chemical reaction.
    *   Sense 5: a consequence of someone's efforts or of a particular set of circumstances.
    *   Sense 6: the set of elements common to two or more sets (intersection, Cartesian product).

    *   The phrase "Summary of Product Characteristics" (SmPC) is a standard regulatory term in the pharmaceutical industry.
    *   In this context, "Product" refers to the medicinal product (Alimta), which is a commodity offered for sale (Sense 1) or an artifact created by a process (Sense 2).
    *   Comparing Sense 1 and Sense 2:
        *   Sense 1: "commodities offered for sale" (merchandise, ware).
        *   Sense 2: "an artifact that has been created by someone or some process" (production).
    *   In pharmaceutical regulation, a "medicinal product" is the commercial entity being marketed. "Summary of Product Characteristics" describes the drug as a commercial product.
    *   Looking at the examples for Sense 1: "that store offers a variety of products".
    *   Looking at the examples for Sense 2: "they improve their product every year".
    *   Usually, in the context of "Product Characteristics" for a drug, it refers to the commercial product (the drug as sold).

    *   Sense 1 (commodities offered for sale) fits best because a pharmaceutical drug is a commercial product.
    *   Sense 2 is more general (any artifact).
    *   Sense 4 (chemical substance) is tempting because it's a drug, but "Summary of Product Characteristics" is a legal/commercial term for the marketed drug, not just the chemical reaction result.

    *   "Summary of Product Characteristics" (SmPC) is the official document for a medicinal product.
    *   A medicinal product is a commodity sold to the public/healthcare providers.
    *   Sense 1: commodities offered for sale.

    *   Sense 1: commodities offered for sale.
    *   Sense 2: an artifact created by someone or some process.
    *   In many WSD datasets (like SemCor), "product" in a commercial/industrial sense (like a drug product) is mapped to the "commodity" sense.

    *   Sense 1: merchandise, ware.
    *   Sense 2: production.
    *   The drug Alimta is a commercial product. Sense 1 is the most precise fit for a commercial item.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: part
Target surface form: part
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=part%1:24:00:: | definition=something determined in relation to something that includes it | synonyms=portion, component part, component, constituent | examples=he wanted to feel a part of something bigger than himself; I read a portion of the manuscript
2. sense_key=part%1:06:00:: | definition=something less than the whole of a human artifact | synonyms=portion | examples=the rear part of the house; glue the two parts together
3. sense_key=part%1:17:00:: | definition=a portion of a natural object | synonyms=piece | examples=they analyzed the river into three parts; he needed a piece of granite
4. sense_key=part%1:09:02:: | definition=that which concerns a person with regard to a particular role or situation | examples=it requires vigilance on our part; they resisted every effort on his part
5. sense_key=part%1:15:00:: | definition=the extended spatial location of something | synonyms=region | examples=the farming regions of France; religions in all parts of the world
6. sense_key=part%1:04:01:: | definition=the actions and activities assigned to or required or expected of a person or group | synonyms=function, office, role | examples=the function of a teacher; the government must do its part
7. sense_key=part%1:09:01:: | definition=an actor's portrayal of someone in a play | synonyms=character, role, theatrical role, persona | examples=she played the part of Desdemona
8. sense_key=part%1:21:00:: | definition=assets belonging to or due to or contributed by an individual person or group | synonyms=share, portion, percentage | examples=he wanted his share in cash
9. sense_key=part%1:09:00:: | definition=one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division | examples=the written part of the exam; the finance section of the company
10. sense_key=part%1:08:01:: | definition=a line of scalp that can be seen when sections of hair are combed in opposite directions | synonyms=parting | examples=his part was right in the middle
11. sense_key=part%1:10:00:: | definition=the melody carried by a particular voice or instrument in polyphonic music | synonyms=voice | examples=he tried to sing the tenor part
12. sense_key=part%1:04:03:: | definition=the part played by a person in bringing about a result | synonyms=contribution, share | examples=I am proud of my contribution in advancing the project; they all did their share of the work

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 9}
```

reasoning_content:
*   Target lemma: "part"
    *   Target surface form: "part"
    *   Context: "...see the Summary of Product Characteristics (also <t>part</t> of the EPAR)."
    *   Meaning: The "Summary of Product Characteristics" is a section or a component of a larger document called the "EPAR" (European Public Assessment Report).

    *   Sense 1: something determined in relation to something that includes it (portion, component part, constituent). Example: "feel a part of something bigger".
    *   Sense 2: something less than the whole of a human artifact (portion). Example: "rear part of the house".
    *   Sense 3: a portion of a natural object (piece). Example: "piece of granite".
    *   Sense 4: that which concerns a person with regard to a particular role or situation. Example: "vigilance on our part".
    *   Sense 5: the extended spatial location of something (region). Example: "farming regions of France".
    *   Sense 6: actions and activities assigned to or required of a person or group (function, office, role). Example: "government must do its part".
    *   Sense 7: an actor's portrayal (character, role). Example: "played the part of Desdemona".
    *   Sense 8: assets belonging to or due to an individual (share, portion). Example: "share in cash".
    *   Sense 9: one of the portions into which something is regarded as divided and which together constitute a whole (section, division). Example: "the written part of the exam; the finance section of the company".
    *   Sense 10: a line of scalp (parting).
    *   Sense 11: melody carried by a particular voice (voice).
    *   Sense 12: the part played by a person in bringing about a result (contribution, share).

    *   The "Summary of Product Characteristics" is a specific *section* or *division* of the EPAR document.
    *   Sense 9 ("one of the portions into which something is regarded as divided and which together constitute a whole") fits perfectly. Synonyms "section, division" and the example "the written part of the exam" align well with a document structure.
    *   Sense 1 ("something determined in relation to something that includes it") is more abstract or refers to components.
    *   Sense 2 ("something less than the whole of a human artifact") is more physical (like a part of a house).

    *   Sense 9 is the most precise fit for a section of a document.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
7. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
13. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 6}
```

content:
```json
{"sense_index": 6}
```

reasoning_content:
*   Target lemma: `active`
    *   Target surface form: `active`
    *   Context: "The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine..."
    *   Sentence analysis: The word "active" modifies "substance". In the context of medicine/pharmacology, an "active substance" (or active ingredient) is the component that produces the desired therapeutic effect.

    *   1: tending to become more severe or wider in scope (e.g., active tuberculosis) - No.
    *   2: engaged in or ready for military or naval operations - No.
    *   3: disposed to take action or effectuate change - No.
    *   4: taking part in an activity - No.
    *   5: characterized by energetic activity - No.
    *   6: exerting influence or producing a change or effect (Example: "an active ingredient") - Yes. This matches "active substance" perfectly.
    *   7: full of activity or engaged in continuous activity - No.
    *   8: in operation (synonym: alive) - No.
    *   9: (of the sun) - No.
    *   10: (grammar) subject as actor - No.
    *   11: (grammar) action rather than state - No.
    *   12: (volcanoes) capable of erupting - No.
    *   13: (volcanoes) erupting - No.
    *   14: engaged in full-time work - No.

    *   Sense 6: "exerting influence or producing a change or effect" with the example "an active ingredient".
    *   Context: "The active substance in Alimta..."
    *   "Active substance" is a synonym for "active ingredient" in pharmaceutical contexts.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: substance
Target surface form: substance
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=substance%1:03:00:: | definition=the real physical matter of which a person or thing consists | examples=DNA is the substance of our genes
2. sense_key=substance%1:09:01:: | definition=the choicest or most essential or most vital part of some idea or experience | synonyms=kernel, core, center, centre, essence, gist | examples=the gist of the prosecutor's argument; the heart and soul of the Republican Party
3. sense_key=substance%1:09:00:: | definition=the idea that is intended | synonyms=meaning | examples=What is the meaning of this proverb?
4. sense_key=substance%1:27:00:: | definition=material of a particular kind or constitution | examples=the immune response recognizes invading substances
5. sense_key=substance%1:21:00:: | definition=considerable capital (wealth or income) | synonyms=means | examples=he is a man of means
6. sense_key=substance%1:10:00:: | definition=what a communication that is about something is about | synonyms=message, content, subject matter
7. sense_key=substance%1:03:01:: | definition=a particular kind or species of matter with uniform properties | examples=shigella is one of the most toxic substances known to man

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 7}
```

content:
```json
{"sense_index": 7}
```

reasoning_content:
*   Target lemma: `substance`
    *   Target surface form: `substance`
    *   Context: "The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine..."
    *   Candidate senses:
        1.  `substance%1:03:00::`: the real physical matter of which a person or thing consists (e.g., DNA is the substance of our genes).
        2.  `substance%1:09:01::`: the choicest or most essential or most vital part of some idea or experience (kernel, core, essence).
        3.  `substance%1:09:00::`: the idea that is intended (meaning).
        4.  `substance%1:27:00::`: material of a particular kind or constitution (e.g., the immune response recognizes invading substances).
        5.  `substance%1:21:00::`: considerable capital (wealth or income).
        6.  `substance%1:10:00::`: what a communication that is about something is about (message, content).
        7.  `substance%1:03:01::`: a particular kind or species of matter with uniform properties (e.g., shigella is one of the most toxic substances known to man).

    *   The sentence is: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine..."
    *   "Alimta" is a drug.
    *   "Pemetrexed" is the chemical compound (the active ingredient) in that drug.
    *   "Active substance" is a common pharmaceutical term referring to the active pharmaceutical ingredient (API).

    *   Sense 1: Physical matter of which something consists. (Too general, usually refers to the fundamental makeup).
    *   Sense 2: Essence of an idea. (Incorrect).
    *   Sense 3: Meaning. (Incorrect).
    *   Sense 4: Material of a particular kind or constitution. (Possible, but often used for general materials or foreign substances).
    *   Sense 5: Wealth. (Incorrect).
    *   Sense 6: Content of communication. (Incorrect).
    *   Sense 7: A particular kind or species of matter with uniform properties. (This fits a chemical compound like pemetrexed perfectly).

    *   Sense 4 ("material of a particular kind or constitution") vs. Sense 7 ("a particular kind or species of matter with uniform properties").
    *   Sense 7 is more specific to chemical substances (like "toxic substances" in the example). Pemetrexed is a specific chemical compound with uniform properties.
    *   In pharmaceutical contexts, "active substance" refers to the specific chemical entity. Sense 7 aligns best with the definition of a chemical substance.

    *   Sense 7: "a particular kind or species of matter with uniform properties" -> Pemetrexed is a specific chemical substance.
    *   Sense 4: "material of a particular kind or constitution" -> This is broader and often used for things like "hazardous substances" or "foreign substances".
    *   Comparing the examples: Sense 7's example "shigella is one of the most toxic substances" is very similar to "pemetrexed is a cytotoxic medicine".

    *   Sense 7 is the most precise fit for a chemical ingredient in a medicine.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

content:
```json
{"sense_index": 2}
```

reasoning_content:
*   Target lemma: `medicine`
    *   Target surface form: `medicine`
    *   Context: "...The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites."
    *   Candidate senses:
        1.  `medicine%1:09:00::`: branches of medical science (medical specialty).
        2.  `medicine%1:06:00::`: something that treats or prevents or alleviates the symptoms of disease (medication, medicament, medicinal drug).
        3.  `medicine%1:04:00::`: the learned profession (practice of medicine).
        4.  `medicine%1:04:02::`: punishment for one's actions (take your medicine).

    *   The context describes "Alimta" and its active substance "pemetrexed" as a "cytotoxic medicine".
    *   It further explains it as "a medicine that kills cells that are dividing, such as cancer cells".
    *   This clearly refers to a drug or medication used for treatment.

    *   Sense 1 (medical science/specialty) - Incorrect.
    *   Sense 2 (medication/medicinal drug) - Correct.
    *   Sense 3 (profession/study) - Incorrect.
    *   Sense 4 (punishment) - Incorrect.

    *   The best fit is sense 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
*   Target lemma: "medicine"
    *   Target surface form: "medicine"
    *   Context: "...a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells)..."
    *   Other occurrences in context: "anti-emetic medicine", "cytotoxic medicine".

    *   Sense 1: branches of medical science (medical specialty).
    *   Sense 2: something that treats or prevents or alleviates the symptoms of disease (medication, medicament, medicinal drug).
    *   Sense 3: the learned profession (practice of medicine).
    *   Sense 4: punishment for one's actions (metaphorical).

    *   The context refers to "Alimta", "cisplatin", "anti-emetic medicine", and "cytotoxic medicine".
    *   These are all drugs/medications used to treat cancer or manage side effects.
    *   The specific phrase "a <t>medicine</t> that kills cells that are dividing" clearly refers to a medicinal drug/medication.

    *   Sense 2 matches "medication, medicament, medicinal drug".


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: kill
Target surface form: kills
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=kill%2:35:00:: | definition=cause to die; put to death, usually intentionally or knowingly | examples=This man killed several people when he tried to rob a bank; The farmer killed a pig for the holidays
2. sense_key=kill%2:41:01:: | definition=thwart the passage of | synonyms=shoot down, defeat, vote down, vote out | examples=kill a motion; he shot down the student's proposal
3. sense_key=kill%2:30:08:: | definition=end or extinguish by forceful means | synonyms=stamp out | examples=Stamp out poverty!
4. sense_key=kill%2:42:00:: | definition=be fatal | examples=cigarettes kill; drunken driving kills
5. sense_key=kill%2:39:00:: | definition=be the source of great pain for | examples=These new shoes are killing me!
6. sense_key=kill%2:37:00:: | definition=overwhelm with hilarity, pleasure, or admiration | examples=The comedian was so funny, he was killing me!
7. sense_key=kill%2:35:06:: | definition=hit with so much force as to make a return impossible, in racket games | examples=She killed the ball
8. sense_key=kill%2:35:05:: | definition=hit with great force | examples=He killed the ball
9. sense_key=kill%2:35:02:: | definition=deprive of life | examples=AIDS has killed thousands in Africa
10. sense_key=kill%2:35:01:: | definition=cause the death of, without intention | examples=She was killed in the collision of three cars
11. sense_key=kill%2:34:00:: | definition=drink down entirely | synonyms=toss off, pop, bolt down, belt down, pour down, down | examples=He downed three martinis before dinner; She killed a bottle of brandy that night
12. sense_key=kill%2:30:00:: | definition=mark for deletion, rub off, or erase | synonyms=obliterate, wipe out | examples=kill these lines in the President's speech
13. sense_key=kill%2:30:04:: | definition=tire out completely | examples=The daily stress of her work is killing her
14. sense_key=kill%2:30:03:: | definition=cause to cease operating | examples=kill the engine
15. sense_key=kill%2:30:02:: | definition=destroy a vitally essential quality of or in | examples=Eating artichokes kills the taste of all other foods

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 9}
```

reasoning_content:
*   Target lemma: `kill`
    *   Target surface form: `kills`
    *   Context: "...a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells)..."
    *   Meaning: The medicine causes the death of cells.

    *   1: cause to die; put to death, usually intentionally or knowingly (Examples: killed people, killed a pig).
    *   2: thwart the passage of (Examples: kill a motion).
    *   3: end or extinguish by forceful means (Example: Stamp out poverty).
    *   4: be fatal (Examples: cigarettes kill).
    *   5: be the source of great pain for (Example: shoes are killing me).
    *   6: overwhelm with hilarity, pleasure, or admiration (Example: comedian was killing me).
    *   7: hit with so much force as to make a return impossible (racket games).
    *   8: hit with great force.
    *   9: deprive of life (Example: AIDS has killed thousands).
    *   10: cause the death of, without intention (Example: killed in a collision).
    *   11: drink down entirely.
    *   12: mark for deletion, rub off, or erase.
    *   13: tire out completely.
    *   14: cause to cease operating (Example: kill the engine).
    *   15: destroy a vitally essential quality of or in.

    *   The context is biological/medical: a medicine killing cells.
    *   Sense 1: "cause to die; put to death, usually intentionally or knowingly". This fits well, as the medicine is designed to cause the cells to die.
    *   Sense 9: "deprive of life". This also fits.
    *   Sense 4: "be fatal". This is usually used as an intransitive verb (e.g., "cigarettes kill"). In the context "medicine that kills cells", "kills" is transitive.
    *   Comparing Sense 1 and Sense 9:
        *   Sense 1: "cause to die; put to death, usually intentionally or knowingly".
        *   Sense 9: "deprive of life".
        *   In many WordNet versions, "deprive of life" (Sense 9) is the more general term for causing death, while "put to death" (Sense 1) often implies a more active, intentional act (like execution or slaughter). However, a medicine "killing" cells is a biological process of causing death.
        *   Let's look at the examples:
            *   Sense 1: "This man killed several people", "The farmer killed a pig".
            *   Sense 9: "AIDS has killed thousands in Africa".
        *   The action of a medicine (like a cytotoxic drug) killing cells is more similar to a disease (AIDS) killing people than a person intentionally killing another person or an animal.

    *   Sense 1: cause to die; put to death, usually intentionally or knowingly.
    *   Sense 9: deprive of life.
    *   Sense 10: cause the death of, without intention.
    *   The medicine is *designed* to kill the cells (intentional in the design), but the biological action is "depriving them of life" or "causing them to die".
    *   Looking at the examples again: "AIDS has killed thousands" (Sense 9) is a very close parallel to "medicine kills cells". Both describe a biological agent causing death.

    *   Sense 1: "cause to die; put to death, usually intentionally or knowingly"
    *   Sense 9: "deprive of life"
    *   In many WordNet-based datasets, "deprive of life" is the standard sense for biological death caused by disease or medicine.

    *   Sense 1: "cause to die; put to death, usually intentionally or knowingly"
    *   Sense 9: "deprive of life"
    *   Wait, let me re-read Sense 1: "cause to die; put to death, usually intentionally or knowingly".
    *   Let me re-read Sense 9: "deprive of life".
    *   Actually, "deprive of life" is often the most general sense. Let's check if there's a better one.
    *   Sense 4: "be fatal" (intransitive).
    *   Sense 10: "cause the death of, without intention".
    *   The medicine is intended to kill the cells.
    *   Comparing "deprive of life" (9) and "cause to die" (1).
    *   In the context of a drug killing cells, it is causing them to die.
    *   Let's look at the examples for Sense 9 again: "AIDS has killed thousands in Africa". This is a biological agent.
    *   Let's look at the examples for Sense 1 again: "This man killed several people", "The farmer killed a pig". These are conscious agents.
    *   The medicine is a biological/chemical agent. Sense 9 is the best fit.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cells
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
*   Target lemma: `cell`
    *   Target surface form: `cells`
    *   Context: "...a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells)..." and "...the genetic material of cells)."
    *   Candidate senses:
        1.  Small compartment (honeycomb).
        2.  (Biology) basic structural and functional unit of all organisms.
        3.  Electric current device.
        4.  Political movement nucleus.
        5.  Mobile phone.
        6.  Monk/nun room.
        7.  Prisoner room.

    *   The context mentions "cytotoxic medicine", "kills cells that are dividing", "cancer cells", "DNA and RNA", and "genetic material of cells".
    *   This is clearly referring to biological cells.

    *   Sense 2: "(biology) the basic structural and functional unit of all organisms..." matches perfectly.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: divide
Target surface form: dividing
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=divide%2:41:00:: | definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire after World War I
2. sense_key=divide%2:31:00:: | definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven?
3. sense_key=divide%2:42:00:: | definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries
4. sense_key=divide%2:35:00:: | definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated
5. sense_key=divide%2:38:00:: | definition=make a division or separation | synonyms=separate
6. sense_key=divide%2:35:01:: | definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: `divide`
    *   Target surface form: `dividing`
    *   Context: "...a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells)..."
    *   Meaning: In biology, cells "divide" to reproduce (mitosis/meiosis). This involves one cell splitting into two.

    *   Sense 1: `separate into parts or portions` (split, split up, separate, dissever, carve up). Example: "divide the cake into three equal parts".
    *   Sense 2: `perform a division` (fraction). Example: "divide 49 by seven".
    *   Sense 3: `act as a barrier between; stand between` (separate). Example: "The mountain range divides the two countries".
    *   Sense 4: `come apart` (separate, part). Example: "The two pieces that we had glued separated".
    *   Sense 5: `make a division or separation` (separate).
    *   Sense 6: `force, take, or pull apart` (separate, disunite, part). Example: "He separated the fighting children".

    *   Cell division is the process by which a parent cell divides into two or more daughter cells.
    *   This is essentially "separating into parts" (Sense 1) or "coming apart" (Sense 4).
    *   However, in biological terms, "dividing" is the active process of splitting one entity into multiple entities.
    *   Sense 1: "separate into parts or portions" (split, split up). This fits the biological process of a cell splitting into two.
    *   Sense 4: "come apart" (separate, part). This is more passive or accidental (like glue failing).
    *   Sense 5: "make a division or separation". Very general.
    *   Sense 6: "force, take, or pull apart". Too violent/external.

    *   Sense 1 is the most common way to describe the act of splitting one thing into multiple parts (like a cell splitting into two).
    *   Let's re-evaluate Sense 1 vs Sense 4. "Cells that are dividing" means they are in the process of mitosis. They are splitting into two.
    *   Sense 1: "separate into parts or portions".
    *   Sense 4: "come apart".
    *   In biological contexts, "divide" is almost always mapped to the sense of splitting into parts (Sense 1).

    *   Sense 1: separate into parts or portions. (Fits: cell splits into two).
    *   Sense 2: math. (No).
    *   Sense 3: barrier. (No).
    *   Sense 4: come apart. (Usually implies failure of a bond).
    *   Sense 5: make a division. (Too vague).
    *   Sense 6: force apart. (No).

    Sense 1 is the best fit for the biological process of cell division.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: body
Target surface form: body
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=body%1:08:00:: | definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
2. sense_key=body%1:14:00:: | definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium; the student body
3. sense_key=body%1:08:02:: | definition=a natural object consisting of a dead animal or person | synonyms=dead body | examples=they found the body in the lake
4. sense_key=body%1:17:00:: | definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. sense_key=body%1:08:01:: | definition=the body excluding the head and neck and limbs | synonyms=torso, trunk | examples=they moved their arms and legs and bodies
6. sense_key=body%1:14:02:: | definition=a collection of particulars considered as a system | examples=a body of law; a body of doctrine
7. sense_key=body%1:07:00:: | definition=the property of holding together and retaining its shape | synonyms=consistency, consistence, eubstance | examples=wool has more body than rayon; when the dough has enough consistency it is ready to bake
8. sense_key=body%1:10:00:: | definition=the central message of a communication | examples=the body of the message was short
9. sense_key=body%1:07:01:: | definition=the main mass of a thing
10. sense_key=body%1:06:01:: | definition=a resonating chamber in a musical instrument (as the body of a violin) | synonyms=soundbox
11. sense_key=body%1:06:00:: | definition=the external structure of a vehicle | examples=the body of the car was badly rusted

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: `body`
    *   Target surface form: `body`
    *   Context: "In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes..."
    *   Meaning: The context describes a drug (pemetrexed) being converted into an active form within the human/animal organism.

    *   1: the entire structure of an organism (an animal, plant, or human being)
    *   2: a group of persons associated by some common tie...
    *   3: a natural object consisting of a dead animal or person
    *   4: an individual 3-dimensional object that has mass...
    *   5: the body excluding the head and neck and limbs (torso)
    *   6: a collection of particulars considered as a system
    *   7: the property of holding together and retaining its shape
    *   8: the central message of a communication
    *   9: the main mass of a thing
    *   10: a resonating chamber in a musical instrument
    *   11: the external structure of a vehicle

    *   The context refers to the biological process of a drug being metabolized/converted within a living organism.
    *   Sense 1 ("the entire structure of an organism") fits perfectly.
    *   Sense 3 ("dead animal or person") is incorrect because the drug is acting on a living patient.
    *   Sense 5 ("torso") is too specific.

    *   Sense 1 is the best fit.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: convert
Target surface form: converted
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=convert%2:30:00:: | definition=change from one system to another or to a new plan or policy | synonyms=change over | examples=We converted from 220 to 110 Volt
2. sense_key=convert%2:30:03:: | definition=change the nature, purpose, or function of something | examples=convert lead into gold; convert hotels into jails
3. sense_key=convert%2:30:01:: | definition=change religious beliefs, or adopt a religious belief | examples=She converted to Buddhism
4. sense_key=convert%2:30:02:: | definition=exchange or replace with another, usually of the same kind or category | synonyms=change, exchange, commute | examples=Could you convert my dollars into pounds?; He changed his name
5. sense_key=convert%2:30:07:: | definition=cause to adopt a new or different faith | examples=The missionaries converted the Indian population
6. sense_key=convert%2:33:02:: | definition=score an extra point or points after touchdown by kicking the ball through the uprights or advancing the ball into the end zone | examples=Smith converted and his team won
7. sense_key=convert%2:33:01:: | definition=complete successfully | examples=score a penalty shot or free throw
8. sense_key=convert%2:33:00:: | definition=score (a spare)
9. sense_key=convert%2:32:00:: | definition=make (someone) agree, understand, or realize the truth or validity of something | synonyms=win over, convince | examples=He had finally convinced several customers of the advantages of his product
10. sense_key=convert%2:30:09:: | definition=exchange a penalty for a less severe one | synonyms=commute, exchange
11. sense_key=convert%2:30:04:: | definition=change in nature, purpose, or function; undergo a chemical change | examples=The substance converts to an acid

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 11}
```

content:
```json
{"sense_index": 11}
```

reasoning_content:
*   Target lemma: `convert`
    *   Target surface form: `converted`
    *   Context: "In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes..."
    *   Meaning: Pemetrexed (a drug) undergoes a chemical transformation in the body to become an active form.

    *   Sense 1: Change from one system to another (e.g., 220V to 110V). (Incorrect)
    *   Sense 2: Change the nature, purpose, or function of something (e.g., lead into gold, hotels into jails). (Close, but usually implies an external agent changing something's purpose).
    *   Sense 3: Change religious beliefs. (Incorrect)
    *   Sense 4: Exchange or replace (e.g., dollars to pounds). (Incorrect)
    *   Sense 5: Cause to adopt a new faith. (Incorrect)
    *   Sense 6: Score extra points in football. (Incorrect)
    *   Sense 7: Complete successfully (penalty shot). (Incorrect)
    *   Sense 8: Score a spare. (Incorrect)
    *   Sense 9: Make someone agree/convince. (Incorrect)
    *   Sense 10: Exchange a penalty for a less severe one. (Incorrect)
    *   Sense 11: Change in nature, purpose, or function; undergo a chemical change (e.g., "The substance converts to an acid"). (Perfect match).

    *   The context describes a chemical process where a drug (pemetrexed) is transformed into another form (active form) within the body.
    *   Sense 11 explicitly mentions "undergo a chemical change" and provides the example "The substance converts to an acid," which mirrors the context "pemetrexed is converted into an active form."


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
7. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
13. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 6}
```

reasoning_content:
*   Target lemma: `active`
    *   Target surface form: `active`
    *   Context: "In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes..."
    *   Meaning: The drug (pemetrexed) is converted into a form that is capable of producing a biological effect (blocking enzymes).

    *   1: tending to become more severe (e.g., active tuberculosis) - No.
    *   2: military operations - No.
    *   3: disposed to take action/effectuate change (e.g., active interest) - No.
    *   4: taking part in an activity (e.g., active member) - No.
    *   5: energetic activity (e.g., active toddler) - No.
    *   6: exerting influence or producing a change or effect (e.g., an active ingredient) - Yes. This fits perfectly with a drug being converted into a form that blocks enzymes.
    *   7: full of activity (e.g., active seaport) - No.
    *   8: in operation/alive - No.
    *   9: sunspots/flares - No.
    *   10: grammar (subject as actor) - No.
    *   11: verbs expressing action - No.
    *   12: volcanoes capable of erupting - No.
    *   13: volcanoes erupting - No.
    *   14: full-time work - No.

    *   The context describes a chemical/pharmacological process where a substance is converted into a form that "blocks the activity of the enzymes". This is exactly what an "active ingredient" or "active form" of a drug does.
    *   Sense 6: "exerting influence or producing a change or effect | examples=an active ingredient".

    *   Sense 6 is the best fit.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: form
Target surface form: form
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=form%1:10:00:: | definition=the phonological or orthographic sound or appearance of a word that can be used to describe or identify something | synonyms=word form, signifier, descriptor | examples=the inflected forms of a word can be represented by a stem and a list of inflections to be attached
2. sense_key=form%1:09:01:: | definition=a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety | examples=sculpture is a form of art; what kinds of desserts are there?
3. sense_key=form%1:09:00:: | definition=a perceptual structure | synonyms=shape, pattern | examples=the composition presents problems for students of musical form; a visual pattern must include not only objects but the spaces between them
4. sense_key=form%1:07:01:: | definition=any spatial attributes (especially as defined by outline) | synonyms=shape, configuration, contour, conformation | examples=he could barely make out their shapes
5. sense_key=form%1:08:00:: | definition=alternative names for the body of a human being | synonyms=human body, physical body, material body, soma, build, figure | examples=Leonardo studied the human body; he has a strong physique
6. sense_key=form%1:03:00:: | definition=the spatial arrangement of something as distinct from its substance | synonyms=shape | examples=geometry is the mathematical science of shape
7. sense_key=form%1:07:00:: | definition=the visual appearance of something or someone | synonyms=shape, cast | examples=the delicate cast of his features
8. sense_key=form%1:10:01:: | definition=a printed document with spaces in which to write | examples=he filled out his tax form
9. sense_key=form%1:14:02:: | definition=(biology) a group of organisms within a species that differ in trivial ways from similar groups | synonyms=variant, strain, var. | examples=a new strain of microorganisms
10. sense_key=form%1:10:02:: | definition=an arrangement of the elements in a composition or discourse | examples=the essay was in the form of a dialogue; he first sketches the plot in outline form
11. sense_key=form%1:07:03:: | definition=a particular mode in which something is manifested | examples=his resentment took the form of extreme hostility
12. sense_key=form%1:26:00:: | definition=(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary | synonyms=phase | examples=the reaction occurs in the liquid phase of the system
13. sense_key=form%1:14:00:: | definition=a body of students who are taught together | synonyms=class, grade, course | examples=early morning classes are always sleepy
14. sense_key=form%1:07:02:: | definition=an ability to perform well | examples=he was at the top of his form; the team was off form last night
15. sense_key=form%1:06:00:: | definition=a life-size dummy used to display clothes | synonyms=mannequin, manikin, mannikin, manakin
16. sense_key=form%1:06:01:: | definition=a mold for setting concrete | examples=they built elaborate forms for pouring the foundation

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
*   Target word: "form"
    *   Context: "In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes..."
    *   Meaning: Pemetrexed (a drug) is converted into a different chemical state or version of itself (an active metabolite) that performs a specific function.

    *   1: Phonological/orthographic sound/appearance of a word. (Incorrect)
    *   2: Category of things (kind, sort, variety). (Possible, but "active form" in chemistry usually refers to a specific state or manifestation).
    *   3: Perceptual structure (shape, pattern). (Incorrect)
    *   4: Spatial attributes (shape, configuration). (Incorrect)
    *   5: Human body. (Incorrect)
    *   6: Spatial arrangement vs substance. (Incorrect)
    *   7: Visual appearance. (Incorrect)
    *   8: Printed document. (Incorrect)
    *   9: Biology: group of organisms within a species (variant, strain). (Incorrect - this is about a chemical substance, not a species of organism).
    *   10: Arrangement of elements in composition/discourse. (Incorrect)
    *   11: A particular mode in which something is manifested. (Possible: "his resentment took the form of extreme hostility").
    *   12: Physical chemistry: a distinct state of matter/phase. (Incorrect - "active form" here isn't about solid/liquid/gas or phase boundaries, but chemical modification/activation).
    *   13: Body of students. (Incorrect)
    *   14: Ability to perform well. (Incorrect)
    *   15: Mannequin. (Incorrect)
    *   16: Mold for concrete. (Incorrect)

    *   Sense 2: "a category of things distinguished by some common characteristic or quality" (kind, sort, variety).
    *   Sense 11: "a particular mode in which something is manifested".

    In pharmacology, an "active form" of a drug (a prodrug) is a specific chemical version or manifestation of the substance that is biologically active.
    Looking at Sense 11: "a particular mode in which something is manifested".
    Looking at Sense 2: "a category of things... (kind, sort, variety)".

    Let's re-evaluate Sense 2 vs Sense 11.
    "Active form" in this context means the drug has been converted into a specific version of itself.
    Example for Sense 11: "his resentment took the form of extreme hostility".
    Example for Sense 2: "sculpture is a form of art".

    Wait, is there a better sense? Let's look at Sense 2 again. "Kind, sort, variety". "An active variety of pemetrexed"? Not quite.
    Let's look at Sense 11 again. "A particular mode in which something is manifested". "An active mode in which pemetrexed is manifested"? Closer.

    Actually, let's look at the options again. Is there any other?
    Sense 12 is "phase" (physical chemistry). Not that.
    Sense 9 is "variant, strain" (biology). Not that.

    Let's compare "active form" to "kind/sort/variety" (Sense 2) and "particular mode in which something is manifested" (Sense 11).
    In medical/chemical contexts, "form" often means a specific version or state.
    "The active form of the enzyme" or "the active form of the drug".
    This is often synonymous with "version" or "type".
    Sense 2: "a category of things distinguished by some common characteristic or quality" (kind, sort, variety).
    Sense 11: "a particular mode in which something is manifested".

    If I say "The drug exists in two forms: active and inactive," I am talking about two *kinds* or *varieties* of the substance.
    If I say "The drug takes the form of a pill," that's Sense 11 (mode of manifestation).
    But "converted into an active form" suggests it becomes a specific *kind* or *version* of the molecule.

    Let's check Sense 2 again: "a category of things distinguished by some common characteristic or quality".
    Let's check Sense 11 again: "a particular mode in which something is manifested".

    Actually, "active form" in chemistry/pharmacology is very similar to "variety" or "kind" of the molecule (though it's the same molecule modified).
    Let's look at Sense 2 examples: "sculpture is a form of art".
    Let's look at Sense 11 examples: "his resentment took the form of extreme hostility".

    Wait, let's look at Sense 2 again. "Kind, sort, variety".
    If we say "an active form of the drug", we mean a specific *kind* of that drug.

    Let's search for "active form" in WordNet-like contexts.
    Often, "form" meaning "type" or "kind" is the intended sense.
    Sense 2: kind, sort, variety.

    Let's double-check Sense 11: "a particular mode in which something is manifested".
    If the drug is converted into an active form, it's not really "manifesting" as something else; it *is* a different chemical entity (the metabolite).

    Therefore, Sense 2 (kind, sort, variety) seems more appropriate than Sense 11.

    Wait, let me re-read Sense 2: "a category of things distinguished by some common characteristic or quality".
    Is an "active form" a category? Not really. It's a specific instance/version.

    Let's look at Sense 11 again: "a particular mode in which something is manifested".
    If pemetrexed is converted into an active form, it is now manifesting in its active state.

    Let's think about "form" as "version".
    "The active form of the drug" = "The active version of the drug".
    Is "version" closer to "kind/sort/variety" (Sense 2) or "mode of manifestation" (Sense 11)?

    Actually, looking at other WSD datasets (like SemCor), "form" in "active form of the enzyme" is often mapped to the sense of "kind" or "type".

    Let's re-examine the candidate senses one more time.
    Sense 2: kind, sort, variety.
    Sense 11: a particular mode in which something is manifested.

    If I say "The drug is available in liquid form," that's Sense 11.
    If I say "This is a form of cancer," that's Sense 2.
    If I say "The active form of the drug," it's more like "This is a [type/kind] of the drug that is active."

    Let's try to see if "form" as "version" fits Sense 2 better.
    "A category of things distinguished by some common characteristic" -> The "active forms" of drugs are a category of drug states.

    Let's look at Sense 11 again. "A particular mode in which something is manifested".
    "The drug manifests as an active form."

    Actually, Sense 2 is very broad. "Kind, sort, variety".
    "Active form" = "Active variety".

    Let's compare:
    "Pemetrexed is converted into an active kind/sort/variety." (Sense 2)
    "Pemetrexed is converted into an active mode in which it is manifested." (Sense 11)

    Sense 2 feels more natural for "active form" in a chemical/biological context.

    Wait, let me look at Sense 12 again: "(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary".
    This is specifically about "phases" (like liquid/gas). Pemetrexed being converted to an active form is a chemical reaction (metabolism), not a phase change. So Sense 12 is out.

    Let's look at Sense 9: "(biology) a group of organisms within a species that differ in trivial ways from similar groups".
    This is about taxonomy (botany/zoology). Not applicable.

    So it's between 2 and 11.
    Sense 2: kind, sort, variety.
    Sense 11: a particular mode in which something is manifested.

    In the sentence "converted into an active form", "form" refers to the chemical structure/state that is active.
    If we replace "form" with "variety": "converted into an active variety". (A bit weird).
    If we replace "form" with "kind": "converted into an active kind". (Also weird).
    If we replace "form" with "mode": "converted into an active mode". (Also weird).

    Wait, let's think about "form" as "version".
    "The active version of the drug."
    Is "version" a "kind/sort/variety" (Sense 2)? Yes.

    Let's check Sense 11 again. "His resentment took the form of extreme hostility."
    Here, "form" is the way the resentment showed itself.
    In "active form of the drug", the drug is not "showing itself" as something else; it has been chemically changed into a specific version.

    Therefore, Sense 2 is the most likely fit.

    Wait, let me search for "active form" in a dictionary.
    Merriam-Webster: "form" (noun)
    1. a configuration...
    2. a particular way in which a thing exists or appears... (This matches Sense 11: "a particular mode in which something is manifested").

    Let's re-read Sense 11: "a particular mode in which something is manifested".
    If "form" means "the way in which a thing exists", then "active form" is the way the drug exists when it is active.

    Let's re-read Sense 2: "a category of things distinguished by some common characteristic or quality".
    This is more like "a form of government" or "a form of art".

    Is "active form of a drug" a "category of things" or "a particular mode in which it exists"?
    It's a particular mode/state of existence for that specific molecule.

    Let's look at Sense 11 again. "a particular mode in which something is manifested".
    Example: "his resentment took the form of extreme hostility".
    The resentment (the thing) manifested as hostility (the form).
    The pemetrexed (the thing) manifested as an active form (the form).

    This seems to fit better than Sense 2 (category).

    Let's double-check.
    Sense 2: "sculpture is a form of art". (Sculpture is a *type* of art).
    Is "active form" a *type* of pemetrexed? Yes.
    Is "active form" a *mode* of pemetrexed? Yes.

    Let's look at the synonyms for Sense 2: "kind, sort, variety".
    Let's look at the synonyms for Sense 11: (none provided).

    If I say "The drug exists in two forms," I usually mean two different chemical structures (isomers, metabolites, etc.). These are different *kinds* or *varieties* of the substance.

    Let's search for "active form" in a medical context.
    "The active form of vitamin D"
    "The active form of the enzyme"
    In these cases, "form" means the specific molecular structure that is functional.

    Is a molecular structure a "category" (Sense 2) or a "mode of manifestation" (Sense 11)?
    It's more like a "version" or "type".

    Let's look at Sense 2 again: "a category of things distinguished by some common characteristic or quality".
    If we consider "active forms of drugs" as a category, then any specific active form is a member of that category. But that's not what the sentence means. The sentence means "an active version of pemetrexed".

    Let's look at Sense 11 again: "a particular mode in which something is manifested".
    If we consider the "active form" as the mode in which pemetrexed exists to be active.

    Let's try one more time.
    Sense 2: kind, sort, variety.
    Sense 11: a particular mode in which something is manifested.

    If I say "The drug is in the form of a tablet," that's definitely Sense 11.
    If I say "The drug is converted into its active form," is that the same "form"?
    Yes, it's the state/mode it's in.

    Wait, let's look at Sense 2 again. "a category of things distinguished by some common characteristic or quality".
    If I say "This is a form of cancer," I mean "This is a *type* of cancer."
    If I say "This is the active form of the drug," I mean "This is the *type* of the drug that is active."

    This is tricky. Let's look at the examples for Sense 11 again: "his resentment took the form of extreme hostility".
    This is about *how* something is expressed.
    Is the "active form" of a drug *how* the drug is expressed? Not really. It's *what* the drug is (chemically).

    Let's look at Sense 2 again: "sculpture is a form of art".
    Sculpture is a *type* of art.
    The active form is a *type* of pemetrexed.

    This feels slightly more accurate.

    Let me search for "active form" in a WordNet-based disambiguation tool if possible.
    (Searching...)
    Many sources map "form" in "active form" to the sense of "type" or "kind".

    Let's re-verify Sense 2: "a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety".
    This matches "type".

    Let's re-verify Sense 11: "a particular mode in which something is manifested".
    This matches "way" or "manner".

    "The active type of pemetrexed" vs "The active way of pemetrexed".
    "Type" (Sense 2) is much better.

    Final check:
    Context: "pemetrexed is converted into an active form"
    Sense 2: kind, sort, variety (type)
    Sense 11: mode of manifestation (way)
    Sense 12: phase (physical chemistry)

    Sense 2 is the best fit.