[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: treatment
Target surface form: Treatment
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. <t>Treatment</t> should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=treatment%1:04:00:: | definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) | synonyms=intervention
2. sense_key=treatment%1:04:01:: | definition=the management of someone or something | synonyms=handling | examples=the handling of prisoners; the treatment of water sewage
3. sense_key=treatment%1:07:00:: | definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture
4. sense_key=treatment%1:10:00:: | definition=an extended communication (often interactive) dealing with some particular topic | synonyms=discussion, discourse | examples=the book contains an excellent discussion of modal logic; his treatment of the race question is badly biased

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: "treatment"
    *   Target surface form: "Treatment"
    *   Context: A medical text describing the administration of Alimta (anticancer chemotherapy), dosage, side effects, and conditions under which the process should be delayed or discontinued.
    *   Sentence: "<t>Treatment</t> should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects."

    *   Sense 1: "care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)" (Synonym: intervention).
    *   Sense 2: "the management of someone or something" (Synonym: handling).
    *   Sense 3: "a manner of dealing with something artistically".
    *   Sense 4: "an extended communication (often interactive) dealing with some particular topic" (Synonyms: discussion, discourse).

    *   The context is clearly medical (anticancer chemotherapy, dose, intravenous infusion, side effects, blood counts).
    *   "Treatment" in this context refers to the medical procedure/application of Alimta to treat cancer.
    *   This aligns perfectly with Sense 1.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: delay
Target surface form: delayed
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be <t>delayed</t> or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=delay%2:30:00:: | definition=cause to be slowed down or delayed | synonyms=detain, hold up | examples=Traffic was delayed by the bad weather; she delayed the work that she didn't want to perform
2. sense_key=delay%2:42:00:: | definition=act later than planned, scheduled, or required | examples=Don't delay your application to graduate school or else it won't be considered
3. sense_key=delay%2:30:01:: | definition=stop or halt | synonyms=stay, detain | examples=Please stay the bloodshed!
4. sense_key=delay%2:30:05:: | definition=slow the growth or development of | synonyms=check, retard | examples=The brain damage will retard the child's language development

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

finish_reason: stop

content:
```json
{"sense_index": 2}
```

role: assistant

reasoning_content:
*   Target lemma: `delay`
    *   Target surface form: `delayed`
    *   Context: "Treatment should be <t>delayed</t> or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects."
    *   Candidate senses:
        1.  `delay%2:30:00::`: cause to be slowed down or delayed (detain, hold up). Example: Traffic was delayed.
        2.  `delay%2:42:00::`: act later than planned, scheduled, or required. Example: Don't delay your application.
        3.  `delay%2:30:01::`: stop or halt (stay, detain). Example: Please stay the bloodshed!
        4.  `delay%2:30:05::`: slow the growth or development of (check, retard). Example: retard the child's language development.

    *   The sentence says "Treatment should be delayed or discontinued...".
    *   In a medical context, "delaying treatment" means postponing the scheduled administration of the drug until a certain condition (like abnormal blood counts) is resolved.
    *   It means the treatment will happen later than originally planned/scheduled.

    *   Sense 1: "cause to be slowed down or delayed". This is often used for physical movement (traffic) or a process being hindered.
    *   Sense 2: "act later than planned, scheduled, or required". This fits perfectly. Postponing the treatment means acting (administering the drug) later than planned.
    *   Sense 3: "stop or halt". This is more like "discontinued" (which is already mentioned as an alternative: "delayed or discontinued").
    *   Sense 4: "slow the growth or development of". This refers to biological or developmental processes, not the timing of a medical procedure.

    *   Sense 2 specifically addresses the timing relative to a plan or schedule ("act later than planned, scheduled, or required"). Medical treatments are typically scheduled.

    *   Sense 1 is "cause to be slowed down". While similar, Sense 2 is more precise for scheduling.
    *   Wait, let's look at the passive voice: "Treatment should be delayed".
    *   If "Treatment" is the subject, is it "acting later than planned"? Or is it "being caused to be slowed down/postponed"?
    *   Actually, looking at Sense 1: "cause to be slowed down or delayed".
    *   Looking at Sense 2: "act later than planned, scheduled, or required".
    *   In "Treatment should be delayed", the treatment isn't "acting"; the doctor is acting. However, in common usage, "the flight was delayed" or "the treatment was delayed" means it happened later than scheduled.
    *   Let's re-evaluate Sense 1 vs Sense 2.
    *   Sense 1: "cause to be slowed down or delayed". Synonyms: detain, hold up.
    *   Sense 2: "act later than planned, scheduled, or required".
    *   If the treatment is the subject, "Treatment should be delayed" means the administration of the treatment should occur later than planned.
    *   Wait, Sense 2 is intransitive ("Don't delay your application" - actually, that's transitive). Let's look at the example: "Don't delay your application". Here "delay" is transitive.
    *   Sense 1: "Traffic was delayed by the bad weather". This is passive. "Treatment should be delayed" is also passive.
    *   Let's look at the definitions again.
    *   Sense 1: "cause to be slowed down or delayed".
    *   Sense 2: "act later than planned, scheduled, or required".
    *   In "Treatment should be delayed", the treatment is being postponed.
    *   Is "Treatment" acting? No.
    *   Is the treatment being "slowed down"? Not exactly. It's being postponed.
    *   Let's look at the WordNet structure if possible. Usually, "delay" as in "postpone" is a specific sense.
    *   Sense 1: "cause to be slowed down or delayed".
    *   Sense 2: "act later than planned, scheduled, or required".
    *   Actually, Sense 2's example "Don't delay your application" means "Don't put off submitting your application". This is exactly what "delay treatment" means.
    *   Sense 1's example "Traffic was delayed" means the progress was slowed.
    *   Medical treatment isn't "slowed down" in its execution; the start of the next dose is postponed.

    *   Sense 2: "act later than planned, scheduled, or required".
    *   If you delay the treatment, you are acting (administering it) later than planned.
    *   Sense 1: "cause to be slowed down or delayed".
    *   Comparing "The flight was delayed" (Sense 1 or 2?) and "The treatment was delayed".
    *   Usually, "delayed" in the sense of "postponed" maps to the "act later than planned" sense.

    *   Sense 1: cause to be slowed down or delayed. (Detain, hold up).
    *   Sense 2: act later than planned, scheduled, or required.
    *   Sense 3: stop or halt.
    *   Sense 4: slow growth.
    *   "Treatment should be delayed" = Treatment should be postponed.
    *   Postponing is acting later than planned.

    *   Sense 1: "Traffic was delayed by the bad weather". (The movement was slowed/stopped).
    *   Sense 2: "Don't delay your application". (Don't postpone the action).
    *   "Treatment should be delayed" = "Don't administer the treatment now; do it later." This matches Sense 2.

    *   Wait, let me double-check Sense 1 again. "cause to be slowed down or delayed".
    *   If the treatment is "delayed", it is being caused to happen later.
    *   Let's look at the synonyms for Sense 1: "detain, hold up". These don't fit "treatment" well.
    *   Let's look at Sense 2 again: "act later than planned, scheduled, or required".
    *   This fits the medical context of a scheduled dose.

    *   Sense 1: cause to be slowed down or delayed.
    *   Sense 2: act later than planned, scheduled, or required.
    *   In "Treatment should be delayed", the treatment is the object of the action (in passive voice). The action is to postpone it.
    *   Sense 2: "Don't delay your application" (Don't postpone it).
    *   This is the most accurate fit.

currency: USD

source: unavailable


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: discontinue
Target surface form: discontinued
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or <t>discontinued</t>, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=discontinue%2:42:00:: | definition=put an end to a state or an activity | synonyms=stop, cease, give up, quit, lay off | examples=Quit teasing your little brother
2. sense_key=discontinue%2:42:01:: | definition=come to or be at an end | examples=the support from our sponsoring agency will discontinue after March 31
3. sense_key=discontinue%2:30:00:: | definition=prevent completion | synonyms=break, break off, stop | examples=stop the project; break off the negotiations

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: `discontinue`
    *   Target surface form: `discontinued`
    *   Context: "Treatment should be delayed or <t>discontinued</t>, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects."
    *   Candidate senses:
        1.  `discontinue%2:42:00::`: put an end to a state or an activity (stop, cease, give up, quit, lay off).
        2.  `discontinue%2:42:01::`: come to or be at an end.
        3.  `discontinue%2:30:00::`: prevent completion (break, break off, stop).

    *   The sentence says "Treatment should be delayed or discontinued...".
    *   In this medical context, "discontinued" means the doctor should stop the treatment (the activity of administering the drug).
    *   It's an action taken by the provider to end the current course of treatment.

    *   Sense 1: "put an end to a state or an activity". This fits perfectly. Stopping a medical treatment is putting an end to an activity.
    *   Sense 2: "come to or be at an end". This is intransitive (the support will discontinue). In the context "Treatment should be... discontinued", it's passive voice, meaning someone (the doctor) puts an end to it. While similar, Sense 1 is the active process of stopping.
    *   Sense 3: "prevent completion". This usually implies stopping something before it's finished (like a project or negotiations). While treatment might be stopped before the full course is complete, the primary meaning here is "stop the activity" rather than "prevent the completion of a specific goal/project".

    *   Sense 1 is the most general and accurate description of stopping a medical treatment. "Stop" is a synonym.
    *   Sense 2 is intransitive.
    *   Sense 3 is more about interruption/breaking off.

    *   "Treatment should be... discontinued" $\rightarrow$ "Treatment should be stopped".
    *   Sense 1: "put an end to a state or an activity" (synonym: stop). This matches.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: dose
Target surface form: dose
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the <t>dose</t> reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=dose%1:06:00:: | definition=a measured portion of medicine taken at any one time | synonyms=dosage
2. sense_key=dose%1:23:00:: | definition=the quantity of an active agent (substance or radiation) taken in or absorbed at any one time | synonyms=dosage
3. sense_key=dose%1:26:00:: | definition=a communicable infection transmitted by sexual intercourse or genital contact | synonyms=venereal disease, VD, venereal infection, social disease, Cupid's itch, Cupid's disease
4. sense_key=dose%1:06:01:: | definition=street name for lysergic acid diethylamide | synonyms=acid, back breaker, battery-acid, dot, Elvis, loony toons

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: `dose`
    *   Target surface form: `dose`
    *   Context: A medical text about the administration of Alimta (anticancer chemotherapy). The specific sentence is: "Treatment should be delayed or discontinued, or the <t>dose</t> reduced, in patients whose blood counts are abnormal or who have certain other side effects."
    *   Candidate senses:
        1.  `dose%1:06:00::`: a measured portion of medicine taken at any one time (synonym: dosage).
        2.  `dose%1:23:00::`: the quantity of an active agent (substance or radiation) taken in or absorbed at any one time (synonym: dosage).
        3.  `dose%1:26:00::`: a communicable infection transmitted by sexual intercourse...
        4.  `dose%1:06:01::`: street name for lysergic acid diethylamide (LSD).

    *   The context is clearly medical, referring to the amount of a drug (Alimta) administered to a patient.
    *   Sense 3 (STD) and Sense 4 (LSD) are completely irrelevant.
    *   Now, distinguish between Sense 1 and Sense 2.
        *   Sense 1: "a measured portion of medicine taken at any one time"
        *   Sense 2: "the quantity of an active agent (substance or radiation) taken in or absorbed at any one time"

    *   Looking closer at the context: "The recommended dose of Alimta is 500 mg per square metre... Treatment should be delayed or discontinued, or the dose reduced..."
    *   In medical terminology, "dose" often refers to the specific amount given at one time (Sense 1) or the general quantity of the active agent (Sense 2).
    *   Wait, let's look at the WordNet distinctions again.
        *   Sense 1 (`dose%1:06:00`): "a measured portion of medicine taken at any one time"
        *   Sense 2 (`dose%1:23:00`): "the quantity of an active agent (substance or radiation) taken in or absorbed at any one time"
    *   These are very similar. Let's check if there's a nuance.
    *   Sense 1 focuses on "medicine" (the product).
    *   Sense 2 focuses on "active agent" (the chemical/substance/radiation).
    *   Alimta is a medicine (pemetrexed).
    *   In the sentence "the dose reduced", it refers to the amount of the drug being administered.
    *   Usually, in these datasets, Sense 1 is the most common usage for a specific amount of medicine. Sense 2 is often used for things like radiation doses or toxicological exposures (absorbed).
    *   Let's re-read: "The recommended dose of Alimta is 500 mg per square metre...". This is a measured portion of medicine.

    *   Sense 1: "a measured portion of medicine taken at any one time"
    *   Sense 2: "the quantity of an active agent (substance or radiation) taken in or absorbed at any one time"
    *   In the context of chemotherapy (Alimta), it's a medicine.
    *   Comparing the two, Sense 1 is the more standard definition for a prescribed amount of medication. Sense 2 is broader (including radiation and absorption).

    *   Sense 1: `dose%1:06:00`
    *   Sense 2: `dose%1:23:00`
    *   Looking at the provided options:
        1. sense_key=dose%1:06:00::
        2. sense_key=dose%1:23:00::
    *   The context "the dose reduced" refers to the amount of medicine. Sense 1 fits perfectly.

    *   Wait, let me double-check if "dosage" (synonym for both) helps.
    *   Actually, looking at WordNet's hierarchy:
        *   `dose%1:06:00` is under `portion`.
        *   `dose%1:23:00` is under `quantity`.
    *   In "the dose reduced", it refers to the quantity of the drug.
    *   However, "a measured portion of medicine" (Sense 1) is the most common way to describe a medical dose.

    *   Let's re-evaluate Sense 2: "the quantity of an active agent (substance or radiation) taken in or absorbed at any one time".
    *   Chemotherapy is an active agent.
    *   But "medicine" (Sense 1) is more specific to the context of a prescribed drug like Alimta.

    *   Let's look at the context again: "The recommended dose of Alimta is 500 mg per square metre...". This is a specific measurement of a medicine.

    *   Comparing Sense 1 and Sense 2 again:
        Sense 1: "a measured portion of medicine taken at any one time"
        Sense 2: "the quantity of an active agent (substance or radiation) taken in or absorbed at any one time"
    *   In many WSD tasks, Sense 1 is used for the medicine itself, and Sense 2 is used for the amount of the active ingredient or radiation.
    *   Given the options, Sense 1 is the most natural fit for a prescribed medication dose.

    *   Target: "dose"
    *   Context: "...or the dose reduced..."
    *   Sense 1: measured portion of medicine.
    *   Sense 2: quantity of active agent.
    *   Alimta is a medicine. The dose is the measured portion.

    *   Wait, let me check if there's any reason to prefer Sense 2. "Active agent" is very technical. "Medicine" is more general. Chemotherapy is a medicine.
    *   Actually, looking at the WordNet structure, `dose%1:06:00` is the primary sense for a medical dose.

    *   Sense 1: dose%1:06:00
    *   Sense 2: dose%1:23:00
    *   Sense 3: dose%1:26:00
    *   Sense 4: dose%1:06:01
    *   The target is clearly Sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: reduce
Target surface form: reduced
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose <t>reduced</t>, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=reduce%2:30:00:: | definition=cut down on; make a reduction in | synonyms=cut down, cut back, trim, trim down, trim back, cut | examples=reduce your daily fat intake; The employer wants to cut back health benefits
2. sense_key=reduce%2:30:06:: | definition=make less complex | examples=reduce a problem to a single question
3. sense_key=reduce%2:41:00:: | definition=bring to humbler or weaker state or condition | examples=He reduced the population to slavery
4. sense_key=reduce%2:40:04:: | definition=simplify the form of a mathematical equation of expression by substituting one term for another
5. sense_key=reduce%2:37:00:: | definition=lower in grade or rank or force somebody into an undignified situation | examples=She reduced her niece to a servant
6. sense_key=reduce%2:30:11:: | definition=be the essential element | synonyms=come down, boil down | examples=The proposal boils down to a compromise
7. sense_key=reduce%2:30:05:: | definition=reduce in size; reduce physically | synonyms=shrink | examples=Hot water will shrink the sweater; Can you shrink this image?
8. sense_key=reduce%2:40:00:: | definition=lessen and make more modest | examples=reduce one's standard of living
9. sense_key=reduce%2:30:04:: | definition=make smaller | synonyms=scale down | examples=reduce an image
10. sense_key=reduce%2:30:03:: | definition=to remove oxygen from a compound, or cause to react with hydrogen or form a hydride, or to undergo an increase in the number of electrons | synonyms=deoxidize, deoxidise
11. sense_key=reduce%2:30:01:: | definition=narrow or limit | synonyms=tighten | examples=reduce the influx of foreigners
12. sense_key=reduce%2:41:03:: | definition=put down by force or intimidation | synonyms=repress, quash, keep down, subdue, subjugate | examples=The government quashes any attempt of an uprising; China keeps down her dissidents very efficiently
13. sense_key=reduce%2:35:00:: | definition=undergo meiosis | examples=The cells reduce
14. sense_key=reduce%2:35:01:: | definition=reposition (a broken bone after surgery) back to its normal site
15. sense_key=reduce%2:30:12:: | definition=destress and thus weaken a sound when pronouncing it
16. sense_key=reduce%2:30:08:: | definition=reduce in scope while retaining essential elements | synonyms=abridge, foreshorten, abbreviate, shorten, cut, contract | examples=The manuscript must be shortened
17. sense_key=reduce%2:30:10:: | definition=be cooked until very little liquid is left | synonyms=boil down, decoct, concentrate | examples=The sauce should reduce to one cup
18. sense_key=reduce%2:30:02:: | definition=cook until very little liquid is left | synonyms=boil down, concentrate | examples=The cook reduced the sauce by boiling it for a long time
19. sense_key=reduce%2:30:09:: | definition=lessen the strength or flavor of a solution or mixture | synonyms=dilute, thin, thin out, cut | examples=cut bourbon
20. sense_key=reduce%2:29:00:: | definition=take off weight | synonyms=melt off, lose weight, slim, slenderize, thin, slim down

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: `reduce`
    *   Target surface form: `reduced`
    *   Context: "Treatment should be delayed or discontinued, or the dose <t>reduced</t>, in patients whose blood counts are abnormal or who have certain other side effects."
    *   Meaning: In this medical context, "the dose reduced" means the amount of medication given to the patient should be decreased.

    *   1: `cut down on; make a reduction in` (Synonyms: cut down, cut back, trim) - Example: "reduce your daily fat intake".
    *   2: `make less complex` - Example: "reduce a problem to a single question".
    *   3: `bring to humbler or weaker state or condition` - Example: "He reduced the population to slavery".
    *   4: `simplify the form of a mathematical equation...`
    *   5: `lower in grade or rank...`
    *   6: `be the essential element` (boil down).
    *   7: `reduce in size; reduce physically` (shrink).
    *   8: `lessen and make more modest` - Example: "reduce one's standard of living".
    *   9: `make smaller` (scale down) - Example: "reduce an image".
    *   10: `remove oxygen from a compound` (chemistry).
    *   11: `narrow or limit` (tighten) - Example: "reduce the influx of foreigners".
    *   12: `put down by force or intimidation` (repress).
    *   13: `undergo meiosis`.
    *   14: `reposition (a broken bone...)`.
    *   15: `destress and thus weaken a sound...`.
    *   16: `reduce in scope while retaining essential elements` (abridge).
    *   17: `be cooked until very little liquid is left`.
    *   18: `cook until very little liquid is left`.
    *   19: `lessen the strength or flavor of a solution or mixture` (dilute).
    *   20: `take off weight`.

    *   The context is about decreasing the amount of a drug dose.
    *   Sense 1 ("cut down on; make a reduction in") fits well. "Reduce your daily fat intake" is very similar to "reduce the dose".
    *   Sense 8 ("lessen and make more modest") is more about lifestyle or standards.
    *   Sense 9 ("make smaller") is often used for physical size or scaling (like an image).
    *   Sense 11 ("narrow or limit") is about restricting flow or quantity of people/things.
    *   Sense 19 ("lessen the strength or flavor... dilute") is about adding solvent, not necessarily reducing the total dose (though it changes concentration).

    *   Sense 1: "cut down on; make a reduction in". This is the most general sense of decreasing the amount of something. Reducing a dose is making a reduction in the amount of medication.

    *   Sense 1: "cut down on; make a reduction in" (Synonyms: cut down, cut back, trim).
    *   Context: "the dose reduced" (meaning the amount of the dose is decreased).
    *   This matches perfectly.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in <t>patients</t> whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: `patient`
    *   Target surface form: `patients`
    *   Context: A medical text describing the administration of Alimta (chemotherapy). The specific sentence is: "Treatment should be delayed or discontinued, or the dose reduced, in <t>patients</t> whose blood counts are abnormal or who have certain other side effects."
    *   Candidate senses:
        1.  `patient%1:18:00::`: a person who requires medical care.
        2.  `patient%1:10:00::`: the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause.

    *   The context is clearly medical ("anticancer chemotherapy", "dose", "doctor", "blood counts", "side effects").
    *   The word "patients" refers to the people receiving the treatment (Alimta).
    *   Sense 1 describes a person requiring medical care.
    *   Sense 2 describes a linguistic/semantic role (the "patient" in a sentence).

    *   Sense 1 is the correct fit for a person receiving medical treatment.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: blood_count
Target surface form: blood counts
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose <t>blood counts</t> are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=blood_count%1:23:00:: | definition=the number of red and white corpuscles in a blood sample
2. sense_key=blood_count%1:04:00:: | definition=the act of estimating the number of red and white corpuscles in a blood sample

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: `blood_count`
    *   Target surface form: `blood counts`
    *   Context: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose <t>blood counts</t> are abnormal or who have certain other side effects."
    *   Candidate senses:
        1.  `blood_count%1:23:00::`: the number of red and white corpuscles in a blood sample (the result/value).
        2.  `blood_count%1:04:00::`: the act of estimating the number of red and white corpuscles in a blood sample (the procedure/test).

    *   The sentence says: "...patients whose blood counts are abnormal..."
    *   "Abnormal" describes the *result* or the *value* of the blood count, not the *act* of counting.
    *   If it were the act of counting, it would be "the blood count was performed incorrectly" or "the blood count took a long time."
    *   Since the counts themselves are "abnormal," it refers to the number of cells (the result).

    *   Sense 1: "the number of red and white corpuscles in a blood sample" (Matches "abnormal blood counts").
    *   Sense 2: "the act of estimating the number..." (Does not match "abnormal blood counts").

    *   The correct sense is 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: abnormal
Target surface form: abnormal
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are <t>abnormal</t> or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=abnormal%3:00:00:: | definition=not normal; not typical or usual or regular or conforming to a norm | synonyms=unnatural | examples=abnormal powers of concentration; abnormal amounts of rain
2. sense_key=abnormal%3:00:03:: | definition=departing from the normal in e.g. intelligence and development | examples=they were heartbroken when they learned their child was abnormal; an abnormal personality
3. sense_key=abnormal%5:00:00:immoderate:00 | definition=much greater than the normal | examples=abnormal profits; abnormal ambition

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: `abnormal`
    *   Target surface form: `abnormal`
    *   Context: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are <t>abnormal</t> or who have certain other side effects."
    *   Candidate senses:
        1.  `abnormal%3:00:00::`: not normal; not typical or usual or regular or conforming to a norm. (General sense of deviation from norm).
        2.  `abnormal%3:00:03::`: departing from the normal in e.g. intelligence and development. (Specific to mental/developmental).
        3.  `abnormal%5:00:00:immoderate:00`: much greater than the normal. (Specifically "too much").

    *   The context refers to "blood counts".
    *   In a medical context, "abnormal blood counts" means the levels of cells (white blood cells, red blood cells, platelets) are either too high or too low compared to the standard reference range.
    *   Sense 1 is a general definition of "not normal" or "not conforming to a norm".
    *   Sense 2 is specific to intelligence/development (not applicable).
    *   Sense 3 is specific to being "much greater than the normal" (too narrow, as blood counts can be abnormally low, which is often the critical concern in chemotherapy).

    *   Sense 1 fits best because "abnormal blood counts" means they deviate from the norm (either higher or lower).

    *   Sense 1: "not normal; not typical or usual or regular or conforming to a norm". This perfectly describes medical test results that fall outside the reference range.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: have
Target surface form: have
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who <t>have</t> certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=have%2:40:00:: | definition=have or possess, either in a concrete or an abstract sense | synonyms=have got, hold | examples=She has $1,000 in the bank; He has got two beautiful daughters
2. sense_key=have%2:42:00:: | definition=have as a feature | synonyms=feature | examples=This restaurant features the most famous chefs in France
3. sense_key=have%2:39:06:: | definition=go through (mental or physical states or experiences) | synonyms=experience, receive, get | examples=get an idea; experience vertigo
4. sense_key=have%2:40:04:: | definition=have ownership or possession of | synonyms=own, possess | examples=He owns three houses in Florida; How many cars does she have?
5. sense_key=have%2:30:00:: | definition=cause to move; cause to be in a certain position or condition | synonyms=get, let | examples=He got his squad on the ball; This let me in for a big surprise
6. sense_key=have%2:34:00:: | definition=serve oneself to, or consume regularly | synonyms=consume, ingest, take in, take | examples=Have another bowl of chicken soup!; I don't take sugar in my coffee
7. sense_key=have%2:41:00:: | definition=have a personal or business relationship with someone | examples=have a postdoc; have an assistant
8. sense_key=have%2:36:00:: | definition=organize or be responsible for | synonyms=hold, throw, make, give | examples=hold a reception; have, throw, or make a party
9. sense_key=have%2:40:01:: | definition=have left | examples=I have two years left; I don't have any money left
10. sense_key=have%2:42:12:: | definition=be confronted with | examples=What do we have here?; Now we have a fine mess
11. sense_key=have%2:30:01:: | definition=undergo | synonyms=experience | examples=The stocks had a fast run-up
12. sense_key=have%2:29:02:: | definition=suffer from; be ill with | examples=She has arthritis
13. sense_key=have%2:32:00:: | definition=cause to do; cause to act in a specified manner | synonyms=induce, stimulate, cause, get, make | examples=The ads induced me to buy a VCR; My children finally got me to buy a computer
14. sense_key=have%2:40:05:: | definition=receive willingly something given or offered | synonyms=accept, take | examples=The only girl who would have him was the miller's daughter; I won't have this dog in my house!
15. sense_key=have%2:40:03:: | definition=get something; come into possession of | synonyms=receive | examples=receive payment; receive a gift
16. sense_key=have%2:29:05:: | definition=undergo (as of injuries and illnesses) | synonyms=suffer, sustain, get | examples=She suffered a fracture in the accident; He had an insulin shock after eating three candy bars
17. sense_key=have%2:40:02:: | definition=achieve a point or goal | synonyms=get, make | examples=Nicklaus had a 70; The Brazilian team got 4 goals
18. sense_key=have%2:29:00:: | definition=cause to be born | synonyms=give birth, deliver, bear, birth | examples=My wife had twins yesterday!
19. sense_key=have%2:35:00:: | definition=have sex with; archaic use | synonyms=take | examples=He had taken this woman when she was most vulnerable

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 3}
```

content:
```json
{"sense_index": 3}
```

reasoning_content:
*   Target lemma: `have`
    *   Target surface form: `have`
    *   Context: "...Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who <t>have</t> certain other side effects."

    *   The sentence discusses patients receiving a drug (Alimta).
    *   It mentions conditions under which treatment should be adjusted: "blood counts are abnormal" or "who <t>have</t> certain other side effects."
    *   "Have" here refers to experiencing or suffering from "side effects."

    *   Sense 1: have or possess (concrete/abstract) - Too general.
    *   Sense 2: have as a feature - Not a feature of the person, but a medical condition.
    *   Sense 3: go through (mental or physical states or experiences) - Possible.
    *   Sense 4: ownership or possession - Not ownership.
    *   Sense 5: cause to move - Irrelevant.
    *   Sense 6: consume regularly - Irrelevant.
    *   Sense 7: personal/business relationship - Irrelevant.
    *   Sense 8: organize/responsible for - Irrelevant.
    *   Sense 9: have left - Irrelevant.
    *   Sense 10: be confronted with - Irrelevant.
    *   Sense 11: undergo (stocks run-up) - Irrelevant.
    *   Sense 12: suffer from; be ill with (e.g., arthritis) - Very strong candidate.
    *   Sense 13: cause to do - Irrelevant.
    *   Sense 14: receive willingly - Irrelevant.
    *   Sense 15: get something/come into possession - Irrelevant.
    *   Sense 16: undergo (as of injuries and illnesses) (e.g., suffered a fracture, had an insulin shock) - Very strong candidate.
    *   Sense 17: achieve a point or goal - Irrelevant.
    *   Sense 18: cause to be born - Irrelevant.
    *   Sense 19: have sex with - Irrelevant.

    *   Sense 12: "suffer from; be ill with" (Example: "She has arthritis").
    *   Sense 16: "undergo (as of injuries and illnesses)" (Example: "He had an insulin shock").
    *   Sense 3: "go through (mental or physical states or experiences)" (Example: "experience vertigo").

    *   "Side effects" are typically things a patient *experiences* or *suffers from* as a result of a drug.
    *   Sense 12 is often used for chronic conditions (arthritis).
    *   Sense 16 is often used for acute events (fracture, insulin shock).
    *   Sense 3 is a general "experience."

    Let's look closer at Sense 16: "undergo (as of injuries and illnesses) | synonyms=suffer, sustain, get".
    Let's look closer at Sense 12: "suffer from; be ill with".

    "Side effects" are not necessarily an "illness" (Sense 12), but they are physical/medical experiences/conditions resulting from treatment.

    Wait, let's re-evaluate Sense 16 vs Sense 12.
    Sense 16: "undergo (as of injuries and illnesses)" - "He had an insulin shock".
    Sense 12: "suffer from; be ill with" - "She has arthritis".

    Side effects are more like "symptoms" or "reactions."
    If I say "I have a headache" or "I have side effects," is that Sense 12 or 16?
    Usually, "have a cold" or "have arthritis" is Sense 12.
    "Had a heart attack" or "had a stroke" is Sense 16.

    Actually, looking at the options again:
    Sense 3: "go through (mental or physical states or experiences) | synonyms=experience, receive, get | examples=get an idea; experience vertigo"
    "Experience vertigo" is very similar to "have side effects."

    Let's compare Sense 3, 12, and 16 again.
    Sense 3: experience vertigo.
    Sense 12: suffer from arthritis.
    Sense 16: suffer a fracture / had an insulin shock.

    "Side effects" are often described as things patients *experience*.
    However, in medical contexts, "have [symptom/side effect]" is extremely common.

    Let's check Sense 16 again: "undergo (as of injuries and illnesses)". Side effects are often categorized as adverse events or illnesses/conditions.
    Let's check Sense 12 again: "suffer from; be ill with".

    If the patient "has side effects," they are experiencing them.
    Sense 3: "go through (mental or physical states or experiences)".
    Sense 16: "undergo (as of injuries and illnesses)".

    Comparing "experience vertigo" (Sense 3) and "had an insulin shock" (Sense 16).
    Side effects (like nausea, fatigue, etc.) are more like vertigo than an insulin shock.

    Wait, let me look at Sense 16's synonyms: "suffer, sustain, get".
    Sense 3's synonyms: "experience, receive, get".

    Let's look at the context again: "...patients whose blood counts are abnormal or who have certain other side effects."
    This is a state of being. "Patients who have side effects."

    If we look at WordNet (the source of these senses), "have" in the sense of "have a cold" or "have a headache" is often mapped to "suffer from" or "experience."

    Let's re-examine Sense 16: "undergo (as of injuries and illnesses)".
    Let's re-examine Sense 12: "suffer from; be ill with".

    Actually, "have side effects" is very similar to "have a disease" or "have a symptom."
    Sense 12: "suffer from; be ill with" (arthritis).
    Sense 16: "undergo (as of injuries and illnesses)" (fracture, insulin shock).

    Is a side effect an "illness" (12) or an "injury/illness" (16)?
    A side effect is an adverse reaction.

    Let's look at Sense 3 again: "go through (mental or physical states or experiences)".
    Example: "experience vertigo".
    Vertigo is a symptom/side effect.

    Let's compare:
    - "have vertigo" (Sense 3)
    - "have arthritis" (Sense 12)
    - "have a fracture" (Sense 16)

    "Side effects" are most similar to "vertigo" (a symptom/experience) than to "arthritis" (a chronic disease) or "a fracture" (an acute injury).

    Wait, let me double-check Sense 16 again. "undergo (as of injuries and illnesses)".
    If "side effects" are viewed as medical conditions the patient is undergoing, 16 fits.
    If "side effects" are viewed as experiences, 3 fits.

    Let's look at the synonyms for 16: "suffer, sustain, get".
    Let's look at the synonyms for 3: "experience, receive, get".

    In medical literature, "patients who experience side effects" is the standard phrasing.
    "Patients who suffer side effects" is also common.

    Let's look at Sense 12 again: "suffer from; be ill with".
    "Patients who suffer from side effects."

    This is tricky. Let's look at the examples again.
    Sense 3: "experience vertigo"
    Sense 12: "She has arthritis"
    Sense 16: "He had an insulin shock"

    "Side effects" are more like "vertigo" (a symptom) than "arthritis" (a disease) or "insulin shock" (a sudden medical event).

    Let's try to find the most precise fit.
    "Patients who have side effects" -> "Patients who experience side effects."
    Sense 3: "go through (mental or physical states or experiences) | synonyms=experience, receive, get | examples=get an idea; experience vertigo"

    Let's check if there's any other sense.
    Sense 1: "have or possess, either in a concrete or an abstract sense"
    Could "side effects" be something you "possess" in an abstract sense? (e.g., "He has a great personality"). No, that's not right.

    Let's re-evaluate Sense 16: "undergo (as of injuries and illnesses)".
    Is a side effect an illness? Not necessarily. It's a reaction.

    Let's re-evaluate Sense 12: "suffer from; be ill with".
    Is having a side effect the same as being "ill with" it? Not exactly.

    Sense 3 seems the most flexible and fits "experience vertigo" perfectly. Vertigo is a symptom, and side effects are symptoms.

    Wait, let me search for "have side effects wordnet sense".
    Often, "have" in "have a cold" is Sense 12.
    "Have a heart attack" is Sense 16.
    "Have a feeling" is Sense 3.

    Is "side effects" more like a "cold" (12), a "heart attack" (16), or a "feeling/vertigo" (3)?
    Side effects can be anything from a mild rash to severe nausea.
    "Experience vertigo" (Sense 3) feels like the closest match for "have side effects."

    Let me double-check Sense 16 one more time. "undergo (as of injuries and illnesses)".
    If the side effect is something like "anaphylactic shock," it's Sense 16.
    If the side effect is "nausea," it's Sense 3.
    Since "side effects" is general, Sense 3 ("experience") is a very strong candidate.

    Wait, let me look at Sense 12 again. "suffer from; be ill with".
    If you "have a cough," is that Sense 12 or Sense 3?
    Usually, "have a cough" is considered "suffer from."

    Let's look at the examples again.
    Sense 3: "experience vertigo"
    Sense 12: "She has arthritis"
    Sense 16: "He had an insulin shock"

    Vertigo is a symptom. Side effects are symptoms.
    Arthritis is a disease.
    Insulin shock is an acute event.

    Therefore, Sense 3 is the best fit.

    Wait, let me think about Sense 16 again. "undergo (as of injuries and illnesses)".
    Is a side effect an "illness"?
    In some contexts, yes. But "experience" (Sense 3) is more general and fits "side effects" better.

    Let's double-check Sense 1. "have or possess, either in a concrete or an abstract sense".
    Some people might argue that you "possess" a symptom. But "experience" is much more precise for medical symptoms.

    Let's compare Sense 3 and Sense 16 again.
    Sense 3: "go through (mental or physical states or experiences)"
    Sense 16: "undergo (as of injuries and illnesses)"

    "Side effects" are physical states or experiences.
    "Experience vertigo" (Sense 3) is almost identical to "experience side effects."

    Final check:
    Context: "...patients whose blood counts are abnormal or who have certain other side effects."
    Sense 3: "go through (mental or physical states or experiences) | synonyms=experience, receive, get | examples=get an idea; experience vertigo"
    This fits perfectly.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: certain
Target surface form: certain
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have <t>certain</t> other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=certain%5:00:00:definite:00 | definition=definite but not specified or identified | examples=set aside a certain sum each week; to a certain degree
2. sense_key=certain%3:00:02:: | definition=having or feeling no doubt or uncertainty; confident and assured | synonyms=sure | examples=felt certain of success; was sure (or certain) she had seen it
3. sense_key=certain%3:00:01:: | definition=established beyond doubt or question; definitely known | examples=what is certain is that every effect must have a cause; it is certain that they were on the bus
4. sense_key=certain%3:00:03:: | definition=certain to occur; destined or inevitable; ; ; - Benjamin Franklin | synonyms=sure | examples=he was certain to fail; his fate is certain
5. sense_key=certain%3:00:05:: | definition=established irrevocably | synonyms=sealed | examples=his fate is sealed
6. sense_key=certain%5:00:00:reliable:00 | definition=reliable in operation or effect | synonyms=sure | examples=a quick and certain remedy; a sure way to distinguish the two
7. sense_key=certain%5:00:00:careful:00 | definition=exercising or taking care great enough to bring assurance | synonyms=sure | examples=be certain to disconnect the iron when you are through; be sure to lock the doors

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: "certain"
    *   Target surface form: "certain"
    *   Context: "...Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have <t>certain</t> other side effects."

    *   Sense 1: "definite but not specified or identified" (e.g., "a certain sum", "to a certain degree").
    *   Sense 2: "having or feeling no doubt or uncertainty; confident and assured" (e.g., "felt certain of success").
    *   Sense 3: "established beyond doubt or question; definitely known" (e.g., "what is certain is that...").
    *   Sense 4: "certain to occur; destined or inevitable" (e.g., "he was certain to fail").
    *   Sense 5: "established irrevocably" (e.g., "his fate is sealed").
    *   Sense 6: "reliable in operation or effect" (e.g., "a quick and certain remedy").
    *   Sense 7: "exercising or taking care great enough to bring assurance" (e.g., "be certain to disconnect the iron").

    *   The phrase is "certain other side effects".
    *   In this context, "certain" is used as a determiner to refer to some specific side effects, but those side effects are not explicitly listed in the sentence.
    *   It means "some specific" or "particular" side effects.
    *   Comparing this to the senses:
        *   Sense 1: "definite but not specified or identified". This fits perfectly. "Certain other side effects" means some specific side effects that are not listed here.
        *   Sense 2: Confident/assured. (Incorrect)
        *   Sense 3: Established beyond doubt. (Incorrect)
        *   Sense 4: Inevitable. (Incorrect)
        *   Sense 5: Irrevocable. (Incorrect)
        *   Sense 6: Reliable. (Incorrect)
        *   Sense 7: Careful. (Incorrect)

    *   Sense 1 is the only one that fits the usage of "certain" as a determiner meaning "some" or "particular".


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: other
Target surface form: other
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain <t>other</t> side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=other%3:00:00:: | definition=not the same one or ones already mentioned or implied; - the White Queen | examples=today isn't any other day; the construction of highways and other public works
2. sense_key=other%5:00:00:past:00 | definition=recently past | examples=the other evening
3. sense_key=other%5:00:02:past:00 | definition=belonging to the distant past | synonyms=early, former | examples=the early inhabitants of Europe; former generations
4. sense_key=other%5:00:00:strange:00 | definition=very unusual; different in character or quality from the normal or expected; - Lance Morrow | examples=a strange, other dimension...where his powers seemed to fail

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: "other"
    *   Target surface form: "other"
    *   Context: "...Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain <t>other</t> side effects."
    *   Candidate senses:
        1.  `other%3:00:00::`: not the same one or ones already mentioned or implied.
        2.  `other%5:00:00:past:00`: recently past.
        3.  `other%5:00:02:past:00`: belonging to the distant past.
        4.  `other%5:00:00:strange:00`: very unusual; different in character or quality from the normal or expected.

    *   The sentence says: "...patients whose blood counts are abnormal or who have certain other side effects."
    *   "Blood counts are abnormal" is one type of side effect/condition.
    *   "Other side effects" refers to side effects *besides* the abnormal blood counts already mentioned.

    *   Sense 1: "not the same one or ones already mentioned or implied". This fits perfectly. The "abnormal blood counts" were mentioned, and "other side effects" refers to side effects that are not abnormal blood counts.
    *   Sense 2: "recently past". Does not fit.
    *   Sense 3: "belonging to the distant past". Does not fit.
    *   Sense 4: "very unusual". While side effects can be unusual, the word "other" here is used to distinguish from the previously mentioned side effect, not to describe the quality of the side effects as "strange".

    *   The word "other" in "other side effects" is used as a determiner meaning "additional" or "different from the one(s) mentioned". This aligns with Sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: side_effect
Target surface form: side effects
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other <t>side effects</t>. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=side_effect%1:26:00:: | definition=a secondary and usually adverse effect of a drug or therapy | examples=severe headaches are one of the side effects of the drug
2. sense_key=side_effect%1:19:00:: | definition=any adverse and unwanted secondary effect | synonyms=fallout | examples=a strategy to contain the fallout from the accounting scandal

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: `side_effect`
    *   Target surface form: `side effects`
    *   Context: A medical text about the drug Alimta, discussing dosage, administration, and the need to reduce "side effects" (using corticosteroids, folic acid, etc.) and managing patients with abnormal blood counts or other "side effects".
    *   Candidate senses:
        1.  `side_effect%1:26:00::`: a secondary and usually adverse effect of a drug or therapy.
        2.  `side_effect%1:19:00::`: any adverse and unwanted secondary effect (synonym: fallout).

    *   The context is explicitly about a drug (Alimta) and its administration.
    *   The phrase "To reduce side effects, patients should take a corticosteroid..." and "...patients whose blood counts are abnormal or who have certain other side effects" clearly refers to the medical side effects of a drug/therapy.

    *   Sense 1 specifically mentions "a drug or therapy".
    *   Sense 2 is a more general "adverse and unwanted secondary effect" (like political or social fallout).

    *   Sense 1 is the precise fit for a medical context involving a drug.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: use
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for <t>use</t> in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=use%1:04:00:: | definition=the act of using | synonyms=usage, utilization, utilisation, employment, exercise | examples=he warned against the use of narcotic drugs; skilled in the utilization of computers
2. sense_key=use%1:07:00:: | definition=what something is used for | synonyms=function, purpose, role | examples=the function of an auger is to bore holes; ballet is beautiful but what use is it?
3. sense_key=use%1:07:02:: | definition=a particular service | examples=he put his knowledge to good use; patrons have their uses
4. sense_key=use%1:22:00:: | definition=(economics) the utilization of economic goods to satisfy needs or in manufacturing | synonyms=consumption, economic consumption, usance, use of goods and services | examples=the consumption of energy has increased steadily
5. sense_key=use%1:04:01:: | definition=(psychology) an automatic pattern of behavior in reaction to a specific situation; may be inherited or acquired through frequent repetition | synonyms=habit | examples=owls have nocturnal habits; she had a habit twirling the ends of her hair
6. sense_key=use%1:04:02:: | definition=exerting shrewd or devious influence especially for one's own advantage | synonyms=manipulation | examples=his manipulation of his friends was scandalous
7. sense_key=use%1:07:03:: | definition=(law) the exercise of the legal right to enjoy the benefits of owning property | synonyms=enjoyment | examples=we were given the use of his boat

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: `use`
    *   Target surface form: `use`
    *   Context: "Alimta is not recommended for <t>use</t> in patients with moderate or severe kidney problems."
    *   Candidate senses:
        1.  `use%1:04:00::`: the act of using (synonyms: usage, utilization, employment, exercise). Example: "he warned against the use of narcotic drugs".
        2.  `use%1:07:00::`: what something is used for (synonyms: function, purpose, role). Example: "the function of an auger is to bore holes".
        3.  `use%1:07:02::`: a particular service. Example: "he put his knowledge to good use".
        4.  `use%1:22:00::`: (economics) the utilization of economic goods to satisfy needs or in manufacturing (synonyms: consumption). Example: "the consumption of energy has increased steadily".
        5.  `use%1:04:01::`: (psychology) an automatic pattern of behavior (synonyms: habit). Example: "owls have nocturnal habits".
        6.  `use%1:04:02::`: exerting shrewd or devious influence (synonyms: manipulation). Example: "his manipulation of his friends was scandalous".
        7.  `use%1:07:03::`: (law) the exercise of the legal right to enjoy the benefits of owning property (synonyms: enjoyment). Example: "we were given the use of his boat".

    *   The sentence says "Alimta is not recommended for use in patients with moderate or severe kidney problems."
    *   "Alimta" is a medication.
    *   "Use" here refers to the administration or application of the medication to patients.
    *   This matches the "act of using" or "utilization" of the drug.

    *   Sense 1: "the act of using" / "utilization". Example: "he warned against the use of narcotic drugs". This fits perfectly.
    *   Sense 2: "what something is used for" (purpose/function). Not the purpose of Alimta, but the act of administering it.
    *   Sense 3: "a particular service". Not applicable.
    *   Sense 4: "economic consumption". Not applicable.
    *   Sense 5: "habit". Not applicable.
    *   Sense 6: "manipulation". Not applicable.
    *   Sense 7: "legal right to property". Not applicable.

    *   The context "recommended for use in patients" is almost identical in meaning to the example "warned against the use of narcotic drugs". Both refer to the administration/utilization of a substance.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in <t>patients</t> with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: `patient`
    *   Target surface form: `patients`
    *   Context: A medical text describing the dosage and administration of a drug (Alimta), mentioning "patients should take a corticosteroid", "patients whose blood counts are abnormal", and "Alimta is not recommended for use in <t>patients</t> with moderate or severe kidney problems."
    *   Candidate senses:
        1.  `patient%1:18:00::`: a person who requires medical care.
        2.  `patient%1:10:00::`: the semantic role of an entity that is not the agent... (linguistics term).

    *   The context is clearly medical. It discusses drug dosage, side effects, and medical conditions (kidney problems).
    *   The word "patients" refers to the people receiving the medication.

    *   Sense 1: "a person who requires medical care" - This fits perfectly.
    *   Sense 2: "the semantic role of an entity..." - This is a linguistic term and does not fit the context.

    *   The best sense is index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: moderate
Target surface form: moderate
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with <t>moderate</t> or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=moderate%3:00:00:: | definition=being within reasonable or average limits; not excessive or extreme | examples=moderate prices; a moderate income
2. sense_key=moderate%5:00:00:mild:00 | definition=not extreme | synonyms=temperate | examples=a moderate penalty; temperate in his response to criticism
3. sense_key=moderate%5:00:00:temperate:00 | definition=marked by avoidance of extravagance or extremes | synonyms=restrained | examples=moderate in his demands; restrained in his response

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
*   Target lemma: `moderate`
    *   Target surface form: `moderate`
    *   Context: "Alimta is not recommended for use in patients with <t>moderate</t> or severe kidney problems."
    *   Candidate senses:
        1.  `moderate%3:00:00::`: being within reasonable or average limits; not excessive or extreme (e.g., moderate prices, moderate income).
        2.  `moderate%5:00:00:mild:00`: not extreme (synonym: temperate; e.g., a moderate penalty).
        3.  `moderate%5:00:00:temperate:00`: marked by avoidance of extravagance or extremes (synonym: restrained; e.g., moderate in his demands).

    *   The word "moderate" describes "kidney problems".
    *   In a medical context, "moderate" usually refers to the severity of a condition (mild, moderate, severe).
    *   It means the condition is not mild, but not yet severe. It is "not extreme" but significant.

    *   Sense 1: "being within reasonable or average limits; not excessive or extreme". Examples: "moderate prices", "moderate income". This is often used for quantities or levels.
    *   Sense 2: "not extreme". Synonym: "temperate". Example: "a moderate penalty". This fits the description of severity (not extreme).
    *   Sense 3: "marked by avoidance of extravagance or extremes". Synonym: "restrained". Example: "moderate in his demands". This refers to behavior or personality.

    *   Sense 3 is clearly about behavior/temperament. Incorrect.
    *   Sense 1 is about limits/averages (prices, income).
    *   Sense 2 is about intensity/severity ("not extreme"). In medical terminology, "moderate" (as in moderate kidney problems) means the severity is not extreme (severe) but not mild.

    *   Wait, let's look closer at Sense 1 vs Sense 2.
    *   Sense 1: "being within reasonable or average limits; not excessive or extreme".
    *   Sense 2: "not extreme".
    *   In the context of "moderate or severe kidney problems", "moderate" is a level of severity.
    *   Comparing "moderate prices" (Sense 1) vs "moderate penalty" (Sense 2).
    *   A "moderate penalty" is one that is not extreme. "Moderate kidney problems" are problems that are not extreme (severe).
    *   Sense 1's "reasonable or average limits" doesn't quite fit a medical condition (you wouldn't call kidney problems "reasonable").
    *   Sense 2's "not extreme" fits the scale of mild -> moderate -> severe.

    *   Sense 1: moderate prices, moderate income (quantity/amount).
    *   Sense 2: moderate penalty, temperate response (intensity/severity).
    *   "Moderate kidney problems" refers to the intensity/severity of the condition.

    *   Sense 2 is the best fit.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: severe
Target surface form: severe
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or <t>severe</t> kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=severe%5:00:00:intense:00 | definition=intensely or extremely bad or unpleasant in degree or quality | synonyms=terrible, wicked | examples=severe pain; a severe case of flu
2. sense_key=severe%5:00:00:strong:00 | definition=very strong or vigorous | synonyms=hard, knockout | examples=strong winds; a hard left to the chin
3. sense_key=severe%5:00:00:plain:01 | definition=severely simple | synonyms=austere, stark, stern | examples=a stark interior
4. sense_key=severe%5:00:02:nonindulgent:00 | definition=unsparing and uncompromising in discipline or judgment; - H.G.Wells | synonyms=spartan | examples=a parent severe to the pitch of hostility; a hefty six-footer with a rather severe mien
5. sense_key=severe%5:00:00:critical:03 | definition=causing fear or anxiety by threatening great harm | synonyms=dangerous, grave, grievous, serious, life-threatening | examples=a dangerous operation; a grave situation
6. sense_key=severe%5:00:01:bad:00 | definition=very bad in degree or extent | examples=a severe worldwide depression; the house suffered severe damage

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: `severe`
    *   Target surface form: `severe`
    *   Context: "Alimta is not recommended for use in patients with moderate or <t>severe</t> kidney problems."
    *   Candidate senses:
        1.  `intense`: intensely or extremely bad or unpleasant in degree or quality (e.g., severe pain, severe case of flu).
        2.  `strong`: very strong or vigorous (e.g., strong winds).
        3.  `plain`: severely simple (e.g., stark interior).
        4.  `nonindulgent`: unsparing and uncompromising in discipline or judgment (e.g., a parent severe to the pitch of hostility).
        5.  `critical`: causing fear or anxiety by threatening great harm (e.g., dangerous operation, grave situation).
        6.  `bad`: very bad in degree or extent (e.g., severe worldwide depression, severe damage).

    *   The phrase is "moderate or severe kidney problems."
    *   "Kidney problems" refers to a medical condition or impairment.
    *   "Moderate or severe" describes the degree of the impairment.

    *   Sense 1 (`intense`): "intensely or extremely bad or unpleasant in degree or quality". Examples: "severe pain", "severe case of flu". This fits medical conditions well.
    *   Sense 2 (`strong`): Not applicable (winds, hits).
    *   Sense 3 (`plain`): Not applicable (interiors).
    *   Sense 4 (`nonindulgent`): Not applicable (discipline).
    *   Sense 5 (`critical`): "causing fear or anxiety by threatening great harm". Examples: "dangerous operation", "grave situation". While severe kidney problems can be critical, "severe" here describes the *degree* of the problem, not necessarily the *threat* level (though they are related).
    *   Sense 6 (`bad`): "very bad in degree or extent". Examples: "severe worldwide depression", "severe damage".

    *   Sense 1 focuses on "bad or unpleasant in degree or quality" and gives "severe case of flu" as an example.
    *   Sense 6 focuses on "very bad in degree or extent" and gives "severe damage" as an example.
    *   In medical contexts, "severe" (as in severe kidney disease/problems) usually refers to the degree of impairment or the intensity of the condition.
    *   Comparing "severe case of flu" (Sense 1) and "severe damage" (Sense 6). "Kidney problems" are more like a "case of flu" (a medical condition) than "damage" (though kidney damage exists, "problems" is more general).
    *   Wait, let's look closer at Sense 1 vs Sense 6.
        *   Sense 1: "intensely or extremely bad or unpleasant in degree or quality" (Examples: severe pain, severe case of flu).
        *   Sense 6: "very bad in degree or extent" (Examples: severe worldwide depression, severe damage).
    *   "Severe kidney problems" describes the *extent* or *degree* of the dysfunction.
    *   Actually, in many WordNet-based datasets, "severe" in a medical context (like "severe illness" or "severe symptoms") often maps to the sense meaning "extreme in degree".
    *   Let's re-evaluate Sense 1 and Sense 6.
        *   Sense 1: "intensely or extremely bad or unpleasant in degree or quality".
        *   Sense 6: "very bad in degree or extent".
    *   "Kidney problems" are a condition. "Severe" describes the degree of that condition.
    *   Looking at the examples: "severe case of flu" (Sense 1) is very similar to "severe kidney problems". "Severe damage" (Sense 6) is also close.
    *   However, "severe pain" (Sense 1) is about intensity. "Severe kidney problems" is about the degree of impairment.
    *   Let's check if there's a better fit. Sense 5 (critical/dangerous) is usually for situations or operations.
    *   Between 1 and 6:
        *   Sense 1: "intensely or extremely bad or unpleasant in degree or quality"
        *   Sense 6: "very bad in degree or extent"
    *   "Severe kidney problems" refers to the extent of the dysfunction.
    *   Let's look at the synonyms for Sense 1: "terrible, wicked". These don't fit "severe kidney problems" well.
    *   Sense 6 doesn't have synonyms listed, but the examples "worldwide depression" and "damage" fit the idea of "extent" better.
    *   Wait, let me re-read Sense 1: "intensely or extremely bad or unpleasant in degree or quality". A "severe case of flu" fits this.
    *   Let me re-read Sense 6: "very bad in degree or extent". "Severe damage" fits this.
    *   In medical terminology, "mild, moderate, severe" is a scale of *severity* (degree/extent).
    *   If I have to choose between "bad or unpleasant in degree or quality" (1) and "bad in degree or extent" (6), "extent" (6) feels slightly more precise for a medical grade (mild/moderate/severe), but "severe case of flu" (1) is a direct medical parallel.
    *   Let's look at the examples again.
        *   Sense 1: severe pain, severe case of flu.
        *   Sense 6: severe worldwide depression, severe damage.
    *   "Kidney problems" is more like a "case of flu" than "worldwide depression".

    *   Sense 1: "intensely or extremely bad or unpleasant in degree or quality"
    *   Sense 6: "very bad in degree or extent"
    *   Actually, "severe kidney problems" is a description of the *extent* of the problem.
    *   Let's search for how "severe" is typically categorized in these tasks. Often, "severe" meaning "extreme" in a medical context is mapped to the sense that includes "severe case of flu".
    *   Let's double-check Sense 1's definition: "intensely or extremely bad or unpleasant in degree or quality".
    *   Let's double-check Sense 6's definition: "very bad in degree or extent".
    *   "Severe kidney problems" -> The problems are very bad in degree or extent.
    *   Wait, "severe case of flu" is also "very bad in degree or extent".
    *   This is a very fine distinction. Let's look at the synonyms for Sense 1: "terrible, wicked". These are more about the *quality* of the experience (unpleasantness).
    *   Sense 6 doesn't have synonyms, but "extent" is the key word.
    *   Medical grading (mild, moderate, severe) is almost always about the *extent* of the disease or the *degree* of impairment.

    *   Sense 1: "intensely or extremely bad or unpleasant in degree or quality" (Examples: severe pain, severe case of flu)
    *   Sense 6: "very bad in degree or extent" (Examples: severe worldwide depression, severe damage)
    *   "Severe kidney problems" is a medical classification.
    *   If I look at "severe case of flu", that's also a medical classification.
    *   If I look at "severe damage", that's a classification of extent.
    *   Let's think about "severe pain". Pain is an experience (unpleasant). Kidney problems are a condition (extent of dysfunction).
    *   "Severe case of flu" - the flu is the condition, severe is the degree.
    *   Actually, Sense 1's "unpleasant in degree or quality" might be the key. Kidney problems themselves aren't necessarily "unpleasant" (they can be asymptomatic), but the *condition* is severe.
    *   Sense 6's "very bad in degree or extent" is more neutral and fits "kidney problems" (the extent of the problem) better.

    *   Sense 1: severe pain, severe case of flu.
    *   Sense 6: severe worldwide depression, severe damage.
    *   "Severe kidney problems" is very similar to "severe case of flu".
    *   Let's re-read Sense 1: "intensely or extremely bad or unpleasant in degree or quality".
    *   Let's re-read Sense 6: "very bad in degree or extent".
    *   In the context of "moderate or severe kidney problems", it's describing the *degree* of the problem.
    *   Both 1 and 6 mention "degree". 1 says "degree or quality", 6 says "degree or extent".
    *   "Extent" is a better fit for "kidney problems" (the extent of the impairment).

    *   Wait, I just noticed Sense 1's example "severe case of flu". That is almost identical in structure to "severe kidney problems".
    *   Let's look at Sense 6 again: "severe worldwide depression", "severe damage".
    *   If "severe case of flu" is Sense 1, then "severe kidney problems" is most likely Sense 1.

    *   Sense 1: "intensely or extremely bad or unpleasant in degree or quality"
    *   Sense 6: "very bad in degree or extent"
    *   Is a "case of flu" a "quality" or an "extent"? It's the severity of the illness.
    *   Is "kidney problems" a "quality" or an "extent"? It's the severity of the impairment.
    *   This is tough. Let's look at the synonyms for Sense 1 again: "terrible, wicked". These are very strong words. "Severe kidney problems" doesn't necessarily mean "terrible kidney problems" in the same way "terrible pain" does, but it does mean "very bad".
    *   Let's look at Sense 6 again. "Severe worldwide depression" (economic) and "severe damage". These are about the *scale* or *extent* of the impact.
    *   "Severe kidney problems" is about the *scale* or *extent* of the kidney dysfunction.

    *   Sense 1: severe pain, severe case of flu.
    *   Sense 6: severe worldwide depression, severe damage.
    *   "Severe kidney problems" is a medical condition. "Severe case of flu" is a medical condition.
    *   Therefore, Sense 1 is the most likely intended sense.

    *   Wait, let me search for "severe" in WordNet.
    *   Sense 1: (adj) intense, extreme (e.g., severe pain, severe weather)
    *   Sense 6: (adj) very bad in degree or extent (e.g., severe damage, severe depression)
    *   Actually, looking at other WordNet versions, "severe" as in "severe illness" is often grouped with "severe pain".
    *   Let's re-examine the provided definitions one more time.
    *   Sense 1: "intensely or extremely bad or unpleasant in degree or quality"
    *   Sense 6: "very bad in degree or extent"
    *   "Severe kidney problems" -> The problems are very bad in degree or extent.
    *   "Severe case of flu" -> The case of flu is intensely or extremely bad in degree or quality.
    *   Actually, "severe case of flu" fits Sense 1's example perfectly. "Severe kidney problems" is almost the same thing.

    *   Sense 1: "intensely or extremely bad or unpleasant in degree or quality"
    *   Sense 6: "very bad in degree or extent"
    *   If "severe case of flu" is the example for Sense 1, and "severe kidney problems" is the target, Sense 1 is the most logical choice.

    *   Sense 1: severe pain, severe case of flu.
    *   Sense 6: severe worldwide depression, severe damage.
    *   "Kidney problems" is a medical condition, just like "case of flu".
    *   "Worldwide depression" and "damage" are more about scale/impact.
    *   Therefore, Sense 1 is the best fit.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: problem
Target surface form: problems
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney <t>problems</t>. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=problem%1:26:00:: | definition=a state of difficulty that needs to be resolved | synonyms=job | examples=she and her husband are having problems; it is always a job to contact him
2. sense_key=problem%1:10:00:: | definition=a question raised for consideration or solution | examples=our homework consisted of ten problems to solve
3. sense_key=problem%1:09:00:: | definition=a source of difficulty | synonyms=trouble | examples=one trouble after another delayed the job; what's the problem?

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 3}
```

reasoning_content:
*   Target lemma: `problem`
    *   Target surface form: `problems`
    *   Context: "Alimta is not recommended for use in patients with moderate or severe kidney <t>problems</t>."
    *   Candidate senses:
        1.  `problem%1:26:00::`: a state of difficulty that needs to be resolved (synonym: job).
        2.  `problem%1:10:00::`: a question raised for consideration or solution (e.g., homework problems).
        3.  `problem%1:09:00::`: a source of difficulty (synonym: trouble).

    *   The phrase is "kidney problems".
    *   In a medical context, "kidney problems" refers to kidney dysfunction, disease, or issues affecting the kidney's health.
    *   This is a "source of difficulty" or "trouble" regarding the organ's function.

    *   Sense 1: "a state of difficulty that needs to be resolved". This often refers to interpersonal or situational difficulties (e.g., "having problems" in a marriage).
    *   Sense 2: "a question raised for consideration or solution". This refers to mathematical or logical problems.
    *   Sense 3: "a source of difficulty" (synonym: trouble). "Kidney problems" fits well here as "kidney trouble".

    *   "Kidney trouble" is a common synonym for "kidney problems".
    *   Sense 3 specifically lists "trouble" as a synonym.
    *   Sense 1 is more about a general state of difficulty.
    *   Sense 2 is clearly incorrect.

    *   Sense 3 is the best fit for medical issues/conditions.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: more
Target surface form: more
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For <t>more</t> information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=more%3:00:01:: | definition=(comparative of `much' used with mass nouns) a quantifier meaning greater in size or amount or extent or degree | synonyms=more than | examples=more land; more support
2. sense_key=more%3:00:02:: | definition=(comparative of `many' used with count nouns) quantifier meaning greater in number | examples=a hall with more seats; we have no more bananas

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
*   Target lemma: "more"
    *   Target surface form: "more"
    *   Context: "For <t>more</t> information, see the Summary of Product Characteristics..."
    *   Candidate senses:
        1.  `more%3:00:01::`: comparative of 'much' (mass nouns), greater in size/amount/extent/degree.
        2.  `more%3:00:02::`: comparative of 'many' (count nouns), greater in number.

    *   The word "more" modifies "information".
    *   "Information" is an uncountable (mass) noun in English. You don't say "three informations".

    *   Sense 1 is for mass nouns (comparative of 'much').
    *   Sense 2 is for count nouns (comparative of 'many').
    *   Since "information" is a mass noun, Sense 1 is the correct fit.

    *   Sense 1: "greater in size or amount or extent or degree" (fits "more information").
    *   Sense 2: "greater in number" (does not fit "information").