[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: product
Target surface form: Product
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=product%1:06:01:: | definition=commodities offered for sale | synonyms=merchandise, ware | examples=good business depends on having good merchandise; that store offers a variety of products
2. sense_key=product%1:06:00:: | definition=an artifact that has been created by someone or some process | synonyms=production | examples=they improve their product every year; they export most of their agricultural production
3. sense_key=product%1:09:00:: | definition=a quantity obtained by multiplication | synonyms=mathematical product | examples=the product of 2 and 3 is 6
4. sense_key=product%1:27:00:: | definition=a chemical substance formed as a result of a chemical reaction | examples=a product of lime and nitric acid
5. sense_key=product%1:19:00:: | definition=a consequence of someone's efforts or of a particular set of circumstances | examples=skill is the product of hours of practice; his reaction was the product of hunger and fatigue
6. sense_key=product%1:14:00:: | definition=the set of elements common to two or more sets | synonyms=intersection, Cartesian product | examples=the set of red hats is the intersection of the set of hats and the set of red things

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "Product" in the context of "Summary of Product Characteristics".
The context is about a medicine, Alimta, and its characteristics.
"Summary of Product Characteristics" (SPC) is a standard document for medicinal products.
A medicinal product is an artifact or commodity offered for sale, or a chemical substance.
Wait, let's look at the senses:
1. commodities offered for sale (merchandise, ware)
2. an artifact that has been created by someone or some process (production)
4. a chemical substance formed as a result of a chemical reaction
Wait, "Summary of Product Characteristics" refers to the medicinal product as a commodity or artifact.
Let's check the senses again.
Sense 1: commodities offered for sale. "Summary of Product Characteristics" is a regulatory term for a medicinal product. A medicinal product is a commodity offered for sale.
Sense 2: an artifact that has been created by someone or some process.
Sense 4: a chemical substance formed as a result of a chemical reaction.
Is "Product" in "Summary of Product Characteristics" sense 1 or 2?
In WordNet, "product" as a medicinal product or manufactured good is often sense 1 or 2.
Let's see: "Summary of Product Characteristics" (SPC) is a document that provides information on a medicinal product.
Is a medicinal product a "commodity offered for sale" (sense 1) or "an artifact that has been created by someone or some process" (sense 2)?
Actually, "product" in the context of "Summary of Product Characteristics" refers to the medicinal product, which is a manufactured good, an artifact.
Wait, let's look at the examples for sense 1: "good business depends on having good merchandise; that store offers a variety of products".
Sense 2: "they improve their product every year; they export most of their agricultural production".
"Summary of Product Characteristics" is a specific term. The "product" here is the drug itself, which is a manufactured artifact or commodity.
Let's consider "product" as a manufactured good. Sense 1 is "commodities offered for sale". Sense 2 is "an artifact that has been created by someone or some process".
In WordNet, "product" (artifact) is sense 2. "product" (commodity) is sense 1.
Is a drug a commodity or an artifact?
Often, "product" in "Summary of Product Characteristics" is mapped to sense 1 or 2. Let's think if there's a better fit.
Wait, "Summary of Product Characteristics" is a standard phrase. The "product" is the medicinal product.
Let's search my internal knowledge for "Summary of Product Characteristics" WordNet sense.
Usually, "product" meaning a manufactured good is sense 1 or 2.
Let's look at sense 1: "commodities offered for sale".
Sense 2: "an artifact that has been created by someone or some process".
A medicinal product is an artifact created by a process (manufacturing).
But wait, in WordNet, "product" as in "commercial product" is often sense 1.
Let's check the synonyms for sense 1: merchandise, ware.
Synonyms for sense 2: production.
"Summary of Product Characteristics" -> the product is the drug. A drug is a chemical substance? Sense 4: "a chemical substance formed as a result of a chemical reaction". But SPC is about the whole medicinal product (which includes excipients, packaging, etc.), not just the chemical reaction product.
Let's consider sense 1 vs sense 2.
"Summary of Product Characteristics" (SPC) is a document for a "medicinal product".
Is "medicinal product" a commodity offered for sale? Yes.
Is it an artifact created by someone? Yes.
Which one is more specific or commonly used for "product" in this context?
In many WSD datasets, "product" referring to a commercial good (like a drug, a car, a software) is sense 1 (commodities offered for sale) or sense 2 (artifact).
Let's look at the examples for sense 1: "that store offers a variety of products".
Examples for sense 2: "they improve their product every year".
"Summary of Product Characteristics" is about the characteristics of the product (the drug).
I will guess sense 1, as it's a commercial product (medicinal product).
Wait, "product" in "Summary of Product Characteristics" is often annotated as sense 1 (commodities offered for sale) or sense 2 (artifact).
Let's think about "product" in "Summary of Product Characteristics". The SPC is a regulatory document. The "product" is the medicinal product.
Let's choose sense 1, as it's a commodity offered for sale (a medicine).
Wait, could it be sense 2? "an artifact that has been created by someone or some process".
Let's look at the definition of sense 1: "commodities offered for sale".
Definition of sense 2: "an artifact that has been created by someone or some process".
A medicinal product is definitely an artifact created by a process, but it is also a commodity.
However, in WordNet, "product" meaning a manufactured item is often sense 1.
Let's check the SemCor or OMSTI annotations for "product".
"new product" -> sense 1.
"agricultural product" -> sense 2 (production).
"Summary of Product Characteristics" -> the product is the medicine. Medicine is a commodity offered for sale.
Let's go with 1.
Wait, let's re-read the context: "For more information, see the Summary of Product Characteristics (also part of the EPAR)."
EPAR = European Public Assessment Report.
The "product" here is the medicinal product.
I'll select 1.
Let's reconsider 2. "an artifact that has been created by someone or some process".
Is a drug an artifact? Yes.
But "commodities offered for sale" fits "medicinal product" well, as it's a commercial entity in this context (it's being sold, has a dose, side effects, etc.).
Actually, "product" in "Summary of Product Characteristics" is a fixed phrase. The "product" is the drug.
I will bet on 1.
Let's double check if there's any other sense.
Sense 4: "a chemical substance formed as a result of a chemical reaction". A drug is a chemical substance, but "Summary of Product Characteristics" refers to the formulated medicine, not just the chemical reaction product.
So 1 is the best fit.
Another option: 2. "they improve their product every year".
I'll go with 1.
Wait, "Summary of Product Characteristics" is a translation of "Résumé des Caractéristiques du Produit". In this context, "product" means the medicinal product, which is a commodity.
I will output 1.
Let's think if 2 is better. "an artifact that has been created by someone or some process".
In WordNet, "product" (sense 1) has synonyms: merchandise, ware.
"product" (sense 2) has synonyms: production.
A medicinal product is not typically called "merchandise" or "ware", but it is a "product" in the commercial sense.
However, "production" (sense 2) is more like "agricultural production" or "industrial production".
Therefore, sense 1 is more appropriate for a specific commercial item like a drug.
I will choose 1.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: part
Target surface form: part
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=part%1:24:00:: | definition=something determined in relation to something that includes it | synonyms=portion, component part, component, constituent | examples=he wanted to feel a part of something bigger than himself; I read a portion of the manuscript
2. sense_key=part%1:06:00:: | definition=something less than the whole of a human artifact | synonyms=portion | examples=the rear part of the house; glue the two parts together
3. sense_key=part%1:17:00:: | definition=a portion of a natural object | synonyms=piece | examples=they analyzed the river into three parts; he needed a piece of granite
4. sense_key=part%1:09:02:: | definition=that which concerns a person with regard to a particular role or situation | examples=it requires vigilance on our part; they resisted every effort on his part
5. sense_key=part%1:15:00:: | definition=the extended spatial location of something | synonyms=region | examples=the farming regions of France; religions in all parts of the world
6. sense_key=part%1:04:01:: | definition=the actions and activities assigned to or required or expected of a person or group | synonyms=function, office, role | examples=the function of a teacher; the government must do its part
7. sense_key=part%1:09:01:: | definition=an actor's portrayal of someone in a play | synonyms=character, role, theatrical role, persona | examples=she played the part of Desdemona
8. sense_key=part%1:21:00:: | definition=assets belonging to or due to or contributed by an individual person or group | synonyms=share, portion, percentage | examples=he wanted his share in cash
9. sense_key=part%1:09:00:: | definition=one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division | examples=the written part of the exam; the finance section of the company
10. sense_key=part%1:08:01:: | definition=a line of scalp that can be seen when sections of hair are combed in opposite directions | synonyms=parting | examples=his part was right in the middle
11. sense_key=part%1:10:00:: | definition=the melody carried by a particular voice or instrument in polyphonic music | synonyms=voice | examples=he tried to sing the tenor part
12. sense_key=part%1:04:03:: | definition=the part played by a person in bringing about a result | synonyms=contribution, share | examples=I am proud of my contribution in advancing the project; they all did their share of the work

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

finish_reason: stop

role: assistant

reasoning_content:
The context is: "For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR)."
The target word is "part".
The EPAR (European Public Assessment Report) is a document. The Summary of Product Characteristics is a section or division of this document.
Let's look at the candidate senses:
1. something determined in relation to something that includes it (portion, component part, component, constituent)
2. something less than the whole of a human artifact (portion)
3. a portion of a natural object (piece)
4. that which concerns a person with regard to a particular role or situation
5. the extended spatial location of something (region)
6. the actions and activities assigned to or required or expected of a person or group (function, office, role)
7. an actor's portrayal of someone in a play (character, role, theatrical role, persona)
8. assets belonging to or due to or contributed by an individual person or group (share, portion, percentage)
9. one of the portions into which something is regarded as divided and which together constitute a whole (section, division) - examples: the written part of the exam; the finance section of the company.
10. a line of scalp...
11. the melody carried by a particular voice...
12. the part played by a person in bringing about a result (contribution, share)

Sense 9 fits perfectly: "one of the portions into which something is regarded as divided and which together constitute a whole" (section, division). The Summary of Product Characteristics is a section of the EPAR.
Let's double check sense 1 vs sense 9.
Sense 1: "something determined in relation to something that includes it" (portion, component part, component, constituent). Example: "he wanted to feel a part of something bigger than himself; I read a portion of the manuscript".
Sense 9: "one of the portions into which something is regarded as divided and which together constitute a whole" (section, division). Example: "the written part of the exam; the finance section of the company".
The Summary of Product Characteristics is a section of the EPAR. "part of the EPAR" -> section of the EPAR.
Sense 9 is the best fit.
Let's review the examples for sense 9: "the written part of the exam; the finance section of the company".
Yes, "part of the EPAR" is analogous to "the written part of the exam".
Therefore, sense 9 is the correct choice.
The index is 9.
I will return {"sense_index": 9}.

format: unknown

native_finish_reason: stop

provider: Alibaba

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
7. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
13. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "active" in the context: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine..."
The phrase is "active substance".
Let's look at the candidate senses:
1. tending to become more severe or wider in scope (active tuberculosis)
2. engaged in or ready for military or naval operations
3. disposed to take action or effectuate change
4. taking part in an activity
5. characterized by energetic activity
6. exerting influence or producing a change or effect (an active ingredient)
7. full of activity or engaged in continuous activity
8. in operation
9. (of the sun) characterized by an increased occurrence of sunspots
10. expressing that the subject of the sentence has the semantic function of actor
11. expressing action rather than a state of being
12. capable of erupting
13. erupting or liable to erupt
14. engaged in full-time work

Sense 6: "exerting influence or producing a change or effect" with example "an active ingredient".
"active substance" is synonymous with "active ingredient" in pharmacology.
Therefore, sense 6 is the best fit.
Let's double check.
"active substance in Alimta, pemetrexed, is a cytotoxic medicine"
Yes, "active ingredient" is the exact example for sense 6.
Sense 6 is the correct choice.
The output format must be exactly {"sense_index": 6}.
Done.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: substance
Target surface form: substance
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=substance%1:03:00:: | definition=the real physical matter of which a person or thing consists | examples=DNA is the substance of our genes
2. sense_key=substance%1:09:01:: | definition=the choicest or most essential or most vital part of some idea or experience | synonyms=kernel, core, center, centre, essence, gist | examples=the gist of the prosecutor's argument; the heart and soul of the Republican Party
3. sense_key=substance%1:09:00:: | definition=the idea that is intended | synonyms=meaning | examples=What is the meaning of this proverb?
4. sense_key=substance%1:27:00:: | definition=material of a particular kind or constitution | examples=the immune response recognizes invading substances
5. sense_key=substance%1:21:00:: | definition=considerable capital (wealth or income) | synonyms=means | examples=he is a man of means
6. sense_key=substance%1:10:00:: | definition=what a communication that is about something is about | synonyms=message, content, subject matter
7. sense_key=substance%1:03:01:: | definition=a particular kind or species of matter with uniform properties | examples=shigella is one of the most toxic substances known to man

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "substance" in the context: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine..."
The context refers to a specific chemical or material (pemetrexed) that is the active ingredient in a medicine.
Let's look at the candidate senses:
1. sense_key=substance%1:03:00:: | definition=the real physical matter of which a person or thing consists | examples=DNA is the substance of our genes
2. sense_key=substance%1:09:01:: | definition=the choicest or most essential or most vital part of some idea or experience
3. sense_key=substance%1:09:00:: | definition=the idea that is intended
4. sense_key=substance%1:27:00:: | definition=material of a particular kind or constitution | examples=the immune response recognizes invading substances
5. sense_key=substance%1:21:00:: | definition=considerable capital (wealth or income)
6. sense_key=substance%1:10:00:: | definition=what a communication that is about something is about
7. sense_key=substance%1:03:01:: | definition=a particular kind or species of matter with uniform properties | examples=shigella is one of the most toxic substances known to man

Wait, "active substance" in a medicine refers to a particular kind or species of matter with uniform properties (a chemical compound).
Let's check sense 7: "a particular kind or species of matter with uniform properties". Example: "shigella is one of the most toxic substances known to man". This fits "active substance" (pemetrexed) perfectly, as it is a specific chemical matter.
Let's check sense 1: "the real physical matter of which a person or thing consists".
Let's check sense 4: "material of a particular kind or constitution".
Sense 7 is "a particular kind or species of matter with uniform properties". Pemetrexed is a specific chemical substance.
In WordNet, "substance" as a chemical or specific matter is often sense 7 (substance%1:03:01::).
Let's re-read the example for 7: "shigella is one of the most toxic substances known to man".
Context: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine..."
This is a specific kind of matter with uniform properties (a chemical compound).
Therefore, sense 7 is the best fit.
Let's double check sense 7 vs sense 1. Sense 1 is "the real physical matter of which a person or thing consists" (e.g., DNA is the substance of our genes). Here, pemetrexed is a specific kind of matter, a chemical substance. So sense 7 is better.
Let's double check sense 4: "material of a particular kind or constitution". Example: "the immune response recognizes invading substances". This is also possible, but sense 7 "a particular kind or species of matter with uniform properties" is the standard WordNet sense for a specific chemical or toxic substance.
Wait, let's look at the synsets for "substance".
substance%1:03:01:: is "a particular kind or species of matter with uniform properties".
Yes, "active substance" in pharmacology refers to a specific chemical entity.
I will choose 7.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "medicine" in the context: "The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites."
The context clearly refers to a substance used to treat or prevent disease, specifically a cytotoxic medicine.
Candidate senses:
1. medical specialty
2. something that treats or prevents or alleviates the symptoms of disease (medication, medicament, medicinal drug)
3. the learned profession
4. punishment

Sense 2 is the best fit.
I will return {"sense_index": 2}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "medicine" in the context: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells)..."
The context clearly refers to a substance used to treat or prevent disease, specifically a drug (pemetrexed).
Candidate senses:
1. medical specialty
2. something that treats or prevents or alleviates the symptoms of disease (medication, medicament, medicinal drug)
3. the learned profession
4. punishment

Sense 2 is the best fit.
I will return {"sense_index": 2}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: kill
Target surface form: kills
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=kill%2:35:00:: | definition=cause to die; put to death, usually intentionally or knowingly | examples=This man killed several people when he tried to rob a bank; The farmer killed a pig for the holidays
2. sense_key=kill%2:41:01:: | definition=thwart the passage of | synonyms=shoot down, defeat, vote down, vote out | examples=kill a motion; he shot down the student's proposal
3. sense_key=kill%2:30:08:: | definition=end or extinguish by forceful means | synonyms=stamp out | examples=Stamp out poverty!
4. sense_key=kill%2:42:00:: | definition=be fatal | examples=cigarettes kill; drunken driving kills
5. sense_key=kill%2:39:00:: | definition=be the source of great pain for | examples=These new shoes are killing me!
6. sense_key=kill%2:37:00:: | definition=overwhelm with hilarity, pleasure, or admiration | examples=The comedian was so funny, he was killing me!
7. sense_key=kill%2:35:06:: | definition=hit with so much force as to make a return impossible, in racket games | examples=She killed the ball
8. sense_key=kill%2:35:05:: | definition=hit with great force | examples=He killed the ball
9. sense_key=kill%2:35:02:: | definition=deprive of life | examples=AIDS has killed thousands in Africa
10. sense_key=kill%2:35:01:: | definition=cause the death of, without intention | examples=She was killed in the collision of three cars
11. sense_key=kill%2:34:00:: | definition=drink down entirely | synonyms=toss off, pop, bolt down, belt down, pour down, down | examples=He downed three martinis before dinner; She killed a bottle of brandy that night
12. sense_key=kill%2:30:00:: | definition=mark for deletion, rub off, or erase | synonyms=obliterate, wipe out | examples=kill these lines in the President's speech
13. sense_key=kill%2:30:04:: | definition=tire out completely | examples=The daily stress of her work is killing her
14. sense_key=kill%2:30:03:: | definition=cause to cease operating | examples=kill the engine
15. sense_key=kill%2:30:02:: | definition=destroy a vitally essential quality of or in | examples=Eating artichokes kills the taste of all other foods

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "kills" in the context: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites."
The context is about a medicine that causes the death of cells (cancer cells).
Let's look at the candidate senses:
1. sense_key=kill%2:35:00:: | definition=cause to die; put to death, usually intentionally or knowingly
9. sense_key=kill%2:35:02:: | definition=deprive of life | examples=AIDS has killed thousands in Africa
10. sense_key=kill%2:35:01:: | definition=cause the death of, without intention | examples=She was killed in the collision of three cars

Wait, "cause to die; put to death, usually intentionally or knowingly" (1) vs "deprive of life" (9).
Let's check the examples for 1: "This man killed several people when he tried to rob a bank; The farmer killed a pig for the holidays"
For 9: "AIDS has killed thousands in Africa"
Is a medicine "intentionally or knowingly" causing cells to die? Yes, it's a cytotoxic medicine designed to kill cells.
Wait, let's look at 1: "cause to die; put to death, usually intentionally or knowingly".
Let's look at 9: "deprive of life".
Actually, "kill" in the context of medicine killing cells is often mapped to sense 1 or 9.
Let's consider "cause to die; put to death, usually intentionally or knowingly". A cytotoxic medicine is designed to kill cells.
Wait, let's look at the exact WordNet sense for "kill" meaning "cause to die".
Sense 1: kill%2:35:00:: cause to die; put to death, usually intentionally or knowingly.
Sense 9: kill%2:35:02:: deprive of life.
Is there a better fit?
Let's check the context again: "a medicine that kills cells that are dividing, such as cancer cells"
This is an intentional action by the medicine (or the doctors using it).
Wait, "cause to die; put to death, usually intentionally or knowingly" fits "kills cells".
Let's check if there is a more specific sense.
What about sense 1? "cause to die; put to death, usually intentionally or knowingly"
What about sense 9? "deprive of life"
In WordNet, "kill" (cause to die) is sense 1.
Let's see: "kill%2:35:00::" is "cause to die; put to death, usually intentionally or knowingly".
"kill%2:35:02::" is "deprive of life".
Is a medicine "intentionally" killing cells? Yes, it's a cytotoxic medicine.
Let's search for similar examples. "The medicine kills the bacteria." -> cause to die.
I will choose sense 1.
Wait, let's re-read the definitions.
1. cause to die; put to death, usually intentionally or knowingly
9. deprive of life
In WordNet, "kill" (cause to die) is the most general and common sense for "kill cells".
Let's choose 1.
Wait, could it be 1? Yes.
Let's double check if there's any other.
"kill%2:35:00::" is the first sense of kill (verb).
I'll go with 1.
Let's review the options.
1. cause to die; put to death, usually intentionally or knowingly
9. deprive of life
I'll output 1.
Wait, "deprive of life" is usually for humans or animals. "cause to die" is more general and fits cells.
I will choose 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cells
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "cells" in the context of "a medicine that kills cells that are dividing, such as cancer cells" and "the genetic material of cells".
This clearly refers to the biological unit of life.
Candidate sense 2: "(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals"
This matches perfectly.
Sense index is 2.
Double check:
1. small compartment
2. biology unit
3. electric cell
4. political movement
5. mobile phone
6. monk room
7. prison room

The context is about biology, cancer cells, DNA, RNA.
So sense 2 is the correct one.
Output format: {"sense_index": 2}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: divide
Target surface form: dividing
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=divide%2:41:00:: | definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire after World War I
2. sense_key=divide%2:31:00:: | definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven?
3. sense_key=divide%2:42:00:: | definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries
4. sense_key=divide%2:35:00:: | definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated
5. sense_key=divide%2:38:00:: | definition=make a division or separation | synonyms=separate
6. sense_key=divide%2:35:01:: | definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "dividing" in the context: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells)..."
The context refers to cells that are dividing, i.e., undergoing cell division, separating into parts or portions (mitosis).
Let's look at the candidate senses:
1. sense_key=divide%2:41:00:: | definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire after World War I
2. sense_key=divide%2:31:00:: | definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven?
3. sense_key=divide%2:42:00:: | definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries
4. sense_key=divide%2:35:00:: | definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated
5. sense_key=divide%2:38:00:: | definition=make a division or separation | synonyms=separate
6. sense_key=divide%2:35:01:: | definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea

Wait, cell division is when a cell separates into parts or portions (two daughter cells).
Sense 1: "separate into parts or portions" - this fits cell division (a cell divides into two parts).
Let's check if there is a more specific sense for biological division. No, the candidates are limited to these 6.
Sense 1: "separate into parts or portions"
Sense 4: "come apart"
Sense 5: "make a division or separation"
Sense 1 is the most appropriate for "cells that are dividing" (separating into parts or portions).
Wait, "divide" in biology means to separate into parts or portions.
Let's re-read the candidates.
1. separate into parts or portions
4. come apart
5. make a division or separation

Actually, cell division is a process where a cell separates into parts. "separate into parts or portions" fits perfectly.
Let's consider "divide" as in "cells that are dividing".
Is it sense 1? Yes, "separate into parts or portions".
Let's double check.
"divide the cake into three equal parts"
"cells that are dividing" -> separating into parts.
I will choose sense 1.
Wait, let's look at sense 1 again. "separate into parts or portions".
Is there any other sense?
No.
I'll output 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: body
Target surface form: body
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=body%1:08:00:: | definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
2. sense_key=body%1:14:00:: | definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium; the student body
3. sense_key=body%1:08:02:: | definition=a natural object consisting of a dead animal or person | synonyms=dead body | examples=they found the body in the lake
4. sense_key=body%1:17:00:: | definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. sense_key=body%1:08:01:: | definition=the body excluding the head and neck and limbs | synonyms=torso, trunk | examples=they moved their arms and legs and bodies
6. sense_key=body%1:14:02:: | definition=a collection of particulars considered as a system | examples=a body of law; a body of doctrine
7. sense_key=body%1:07:00:: | definition=the property of holding together and retaining its shape | synonyms=consistency, consistence, eubstance | examples=wool has more body than rayon; when the dough has enough consistency it is ready to bake
8. sense_key=body%1:10:00:: | definition=the central message of a communication | examples=the body of the message was short
9. sense_key=body%1:07:01:: | definition=the main mass of a thing
10. sense_key=body%1:06:01:: | definition=a resonating chamber in a musical instrument (as the body of a violin) | synonyms=soundbox
11. sense_key=body%1:06:00:: | definition=the external structure of a vehicle | examples=the body of the car was badly rusted

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "body" in the context: "In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."
The context refers to the human organism, specifically the physical structure of a human being where a medicine is converted into an active form.
Sense 1: "the entire structure of an organism (an animal, plant, or human being)" - synonyms: organic structure, physical structure.
This perfectly matches the context of a medicine acting within the human organism.
Let's double check other senses.
Sense 3: dead body. No.
Sense 5: torso. No.
Sense 1 is the best fit.
Sense index: 1.
End of thought.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: convert
Target surface form: converted
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=convert%2:30:00:: | definition=change from one system to another or to a new plan or policy | synonyms=change over | examples=We converted from 220 to 110 Volt
2. sense_key=convert%2:30:03:: | definition=change the nature, purpose, or function of something | examples=convert lead into gold; convert hotels into jails
3. sense_key=convert%2:30:01:: | definition=change religious beliefs, or adopt a religious belief | examples=She converted to Buddhism
4. sense_key=convert%2:30:02:: | definition=exchange or replace with another, usually of the same kind or category | synonyms=change, exchange, commute | examples=Could you convert my dollars into pounds?; He changed his name
5. sense_key=convert%2:30:07:: | definition=cause to adopt a new or different faith | examples=The missionaries converted the Indian population
6. sense_key=convert%2:33:02:: | definition=score an extra point or points after touchdown by kicking the ball through the uprights or advancing the ball into the end zone | examples=Smith converted and his team won
7. sense_key=convert%2:33:01:: | definition=complete successfully | examples=score a penalty shot or free throw
8. sense_key=convert%2:33:00:: | definition=score (a spare)
9. sense_key=convert%2:32:00:: | definition=make (someone) agree, understand, or realize the truth or validity of something | synonyms=win over, convince | examples=He had finally convinced several customers of the advantages of his product
10. sense_key=convert%2:30:09:: | definition=exchange a penalty for a less severe one | synonyms=commute, exchange
11. sense_key=convert%2:30:04:: | definition=change in nature, purpose, or function; undergo a chemical change | examples=The substance converts to an acid

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "converted" in the context: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes..."
This refers to a chemical change or change in nature/purpose/function.
Let's look at the candidate senses:
1. change from one system to another
2. change the nature, purpose, or function of something (convert lead into gold)
3. change religious beliefs
4. exchange or replace with another
5. cause to adopt a new faith
6. score an extra point
7. complete successfully
8. score a spare
9. make someone agree
10. exchange a penalty
11. change in nature, purpose, or function; undergo a chemical change (The substance converts to an acid)

Sense 11 explicitly mentions "undergo a chemical change" and the example "The substance converts to an acid" perfectly matches "pemetrexed is converted into an active form".

Let's double check sense 11:
sense_key=convert%2:30:09:: is commute.
sense_key=convert%2:30:04:: is change in nature, purpose, or function; undergo a chemical change. Wait, the prompt says:
11. sense_key=convert%2:30:04:: | definition=change in nature, purpose, or function; undergo a chemical change | examples=The substance converts to an acid

Yes, sense 11 is the best match.
Context: "pemetrexed is converted into an active form" -> undergoes a chemical change.
Sense 11 fits perfectly.
Let's review the prompt's numbering:
11. sense_key=convert%2:30:04:: | definition=change in nature, purpose, or function; undergo a chemical change | examples=The substance converts to an acid

I will output {"sense_index": 11}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
7. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
13. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "active" in the context: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides..."
The phrase is "active form" or "active substance".
Let's look at the candidate senses:
1. tending to become more severe or wider in scope (active tuberculosis)
2. engaged in or ready for military or naval operations
3. disposed to take action or effectuate change
4. taking part in an activity
5. characterized by energetic activity
6. exerting influence or producing a change or effect (an active ingredient)
7. full of activity or engaged in continuous activity
8. in operation
9. (of the sun) characterized by an increased occurrence of sunspots
10. expressing that the subject of the sentence has the semantic function of actor
11. expressing action rather than a state of being
12. capable of erupting
13. erupting or liable to erupt
14. engaged in full-time work

Sense 6: "exerting influence or producing a change or effect" with example "an active ingredient".
The context says "The active substance in Alimta, pemetrexed, is a cytotoxic medicine... converted into an active form that blocks the activity of the enzymes..."
This perfectly matches "exerting influence or producing a change or effect" (like an active ingredient).

Let's double check.
"active form" -> exerting influence or producing a change or effect.
Sense 6 is the best fit.
Context: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine... converted into an active form that blocks the activity of the enzymes..."
Sense 6: exerting influence or producing a change or effect | examples=an active ingredient.

Yes, sense 6 is the correct one.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: form
Target surface form: form
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=form%1:10:00:: | definition=the phonological or orthographic sound or appearance of a word that can be used to describe or identify something | synonyms=word form, signifier, descriptor | examples=the inflected forms of a word can be represented by a stem and a list of inflections to be attached
2. sense_key=form%1:09:01:: | definition=a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety | examples=sculpture is a form of art; what kinds of desserts are there?
3. sense_key=form%1:09:00:: | definition=a perceptual structure | synonyms=shape, pattern | examples=the composition presents problems for students of musical form; a visual pattern must include not only objects but the spaces between them
4. sense_key=form%1:07:01:: | definition=any spatial attributes (especially as defined by outline) | synonyms=shape, configuration, contour, conformation | examples=he could barely make out their shapes
5. sense_key=form%1:08:00:: | definition=alternative names for the body of a human being | synonyms=human body, physical body, material body, soma, build, figure | examples=Leonardo studied the human body; he has a strong physique
6. sense_key=form%1:03:00:: | definition=the spatial arrangement of something as distinct from its substance | synonyms=shape | examples=geometry is the mathematical science of shape
7. sense_key=form%1:07:00:: | definition=the visual appearance of something or someone | synonyms=shape, cast | examples=the delicate cast of his features
8. sense_key=form%1:10:01:: | definition=a printed document with spaces in which to write | examples=he filled out his tax form
9. sense_key=form%1:14:02:: | definition=(biology) a group of organisms within a species that differ in trivial ways from similar groups | synonyms=variant, strain, var. | examples=a new strain of microorganisms
10. sense_key=form%1:10:02:: | definition=an arrangement of the elements in a composition or discourse | examples=the essay was in the form of a dialogue; he first sketches the plot in outline form
11. sense_key=form%1:07:03:: | definition=a particular mode in which something is manifested | examples=his resentment took the form of extreme hostility
12. sense_key=form%1:26:00:: | definition=(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary | synonyms=phase | examples=the reaction occurs in the liquid phase of the system
13. sense_key=form%1:14:00:: | definition=a body of students who are taught together | synonyms=class, grade, course | examples=early morning classes are always sleepy
14. sense_key=form%1:07:02:: | definition=an ability to perform well | examples=he was at the top of his form; the team was off form last night
15. sense_key=form%1:06:00:: | definition=a life-size dummy used to display clothes | synonyms=mannequin, manikin, mannikin, manakin
16. sense_key=form%1:06:01:: | definition=a mold for setting concrete | examples=they built elaborate forms for pouring the foundation

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "form" in the context: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes..."
The context is about a chemical or biological substance (pemetrexed) being converted into an active "form" (a distinct state or manifestation of the substance).
Let's look at the candidate senses:
1. phonological/orthographic sound or appearance
2. category of things
3. perceptual structure
4. spatial attributes
5. human body
6. spatial arrangement
7. visual appearance
8. printed document
9. (biology) a group of organisms within a species
10. arrangement of elements in composition
11. a particular mode in which something is manifested
12. (physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary (synonyms: phase)
13. body of students
14. ability to perform well
15. life-size dummy
16. mold for setting concrete

Wait, "active form" of a medicine. Is it sense 11 (a particular mode in which something is manifested) or sense 12 (physical chemistry, distinct state of matter)? Or maybe sense 2 (kind, sort)?
Let's re-read sense 11: "a particular mode in which something is manifested" - examples: "his resentment took the form of extreme hostility".
Let's re-read sense 12: "(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary" - synonyms: phase.
Wait, "active form" of a drug. Is it a "phase"? No, it's a chemical form, maybe a variant or a mode.
Let's check sense 11: "a particular mode in which something is manifested".
Is there another sense?
What about sense 11 vs sense 12?
"converted into an active form" -> a particular mode in which something is manifested.
Wait, let's look at sense 11: "a particular mode in which something is manifested".
Let's look at sense 12: "a distinct state of matter in a system".
Is "active form" a state of matter? No, it's a chemical state or mode.
Let's consider "form" as in "active form" of a drug.
Could it be sense 11? "a particular mode in which something is manifested"
Let's check WordNet for "form" in "active form".
"form" (noun)
- a particular mode in which something is manifested: "his resentment took the form of extreme hostility"
- (physical chemistry) a distinct state of matter in a system...
- (biology) a group of organisms within a species...
- a category of things distinguished by some common characteristic or quality: "sculpture is a form of art"

Wait, "active form" of a drug. Is it a "mode in which something is manifested"?
Or is it "a category of things distinguished by some common characteristic or quality"?
Or maybe "a particular mode in which something is manifested" (sense 11).
Let's search my internal knowledge for "active form" in WordNet.
"form" - a particular mode in which something is manifested.
Wait, "form" as in "active form" of a drug.
Is there a sense for "chemical form"?
Let's look at sense 11: "a particular mode in which something is manifested".
Let's look at sense 12: "a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary".
Actually, "active form" might be sense 11.
Let's consider "form" as in "a particular mode in which something is manifested".
Wait, could it be sense 11? "a particular mode in which something is manifested"
Let's check the examples for sense 11: "his resentment took the form of extreme hostility".
What about "active form"?
Maybe sense 11 is the best fit.
Let's re-evaluate sense 11: "a particular mode in which something is manifested".
Is there any other sense?
Sense 2: "a category of things distinguished by some common characteristic or quality" (kind, sort, variety). "sculpture is a form of art".
Sense 11: "a particular mode in which something is manifested".
"converted into an active form" -> a particular mode in which the substance is manifested.
Let's check sense 11 again.
Is there a sense for "form" meaning "chemical form"?
In WordNet, "form" has:
- form, shape, pattern (perceptual structure)
- form, shape, configuration, contour, conformation (spatial attributes)
- form, human body, physical body, material body, soma, build, figure (alternative names for the body of a human being)
- form, shape (spatial arrangement of something as distinct from its substance)
- form, shape, cast (visual appearance)
- form, word form, signifier, descriptor (phonological or orthographic sound or appearance)
- form, kind, sort, variety (category of things)
- form, variant, strain, var. (biology)
- form, phase (physical chemistry)
- form (printed document)
- form (arrangement of elements in a composition)
- form (particular mode in which something is manifested)
- form (ability to perform well)
- form, class, grade, course (body of students)
- form, mannequin, manikin, mannikin, manakin (life-size dummy)
- form (mold for setting concrete)

"active form" of a drug. Is it a "phase"? No, it's not a phase like solid, liquid, gas.
Is it a "variant, strain"? No, that's for organisms.
Is it a "particular mode in which something is manifested"? Yes, the drug manifests in an active mode/form.
Let's consider "form" as in "active form".
"converted into an active form"
I will choose sense 11.
Wait, let's look at sense 11: "a particular mode in which something is manifested".
Is there any chance it's sense 2? "a category of things distinguished by some common characteristic or quality". No.
Sense 11 seems the most appropriate for "active form" of a chemical substance, as it refers to a mode of manifestation.
Let's double check if there's any other.
"form" in "active form" -> sense 11.
Let's review the definition of sense 11: "a particular mode in which something is manifested".
Yes, "active form" is a mode in which the substance is manifested.
I'll go with 11.
Wait, let's read sense 11 again: "a particular mode in which something is manifested".
Could it be sense 12? "a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary". No, pemetrexed is converted into an active form (a different chemical structure, not a different phase of the same matter).
So sense 11 is the best.
Let's confirm the index.
11. sense_key=form%1:07:03:: | definition=a particular mode in which something is manifested | examples=his resentment took the form of extreme hostility
Yes, 11.
I will output 11.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: block
Target surface form: blocks
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=block%2:35:00:: | definition=render unsuitable for passage | synonyms=barricade, blockade, stop, block off, block up, bar | examples=block the way; barricade the streets
2. sense_key=block%2:41:00:: | definition=hinder or prevent the progress or accomplishment of | synonyms=obstruct, blockade, hinder, stymie, stymy, embarrass | examples=His brother blocked him at every turn
3. sense_key=block%2:41:01:: | definition=stop from happening or developing | synonyms=stop, halt, kibosh | examples=Block his election; Halt the process
4. sense_key=block%2:32:00:: | definition=interfere with or prevent the reception of signals | synonyms=jam | examples=Jam the Voice of America; block the signals emitted by this station
5. sense_key=block%2:41:03:: | definition=run on a block system | examples=block trains
6. sense_key=block%2:39:05:: | definition=interrupt the normal function of by means of anesthesia | examples=block a nerve; block a muscle
7. sense_key=block%2:39:00:: | definition=shut out from view or get in the way so as to hide from sight | synonyms=obstruct | examples=The thick curtain blocked the action on the stage; The trees obstruct my view of the mountains
8. sense_key=block%2:35:03:: | definition=stamp or emboss a title or design on a book with a block | examples=block the book cover
9. sense_key=block%2:35:02:: | definition=obstruct | synonyms=stuff, lug, choke up | examples=My nose is all stuffed; Her arteries are blocked
10. sense_key=block%2:35:12:: | definition=block passage through | synonyms=obstruct, obturate, impede, occlude, jam, close up | examples=obstruct the path
11. sense_key=block%2:35:06:: | definition=support, secure, or raise with a block | examples=block a plate for printing; block the wheels of a car
12. sense_key=block%2:33:00:: | definition=impede the movement of (an opponent or a ball) | synonyms=parry, deflect | examples=block an attack
13. sense_key=block%2:31:00:: | definition=be unable to remember | synonyms=forget, blank out, draw a blank | examples=I'm drawing a blank; You are blocking the name of your first wife!
14. sense_key=block%2:30:01:: | definition=shape by using a block | examples=Block a hat; block a garment
15. sense_key=block%2:30:00:: | definition=shape into a block or blocks | examples=block the graphs so one can see the results clearly
16. sense_key=block%2:30:02:: | definition=prohibit the conversion or use of (assets) | synonyms=freeze, immobilize, immobilise | examples=Blocked funds; Freeze the assets of this hostile government

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "blocks" in the context: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides..."
The context is about a medicine (pemetrexed) that stops or prevents the activity of enzymes.
Let's look at the candidate senses:
1. render unsuitable for passage (barricade, blockade)
2. hinder or prevent the progress or accomplishment of (obstruct, hinder, stymie)
3. stop from happening or developing (stop, halt, kibosh)
4. interfere with or prevent the reception of signals (jam)
5. run on a block system
6. interrupt the normal function of by means of anesthesia (block a nerve)
7. shut out from view or get in the way so as to hide from sight
8. stamp or emboss
9. obstruct (stuff, choke up)
10. block passage through (obstruct, obturate, impede, occlude)
11. support, secure, or raise with a block
12. impede the movement of (parry, deflect)
13. be unable to remember
14. shape by using a block
15. shape into a block or blocks
16. prohibit the conversion or use of (assets)

Wait, "blocks the activity of the enzymes".
Is it sense 2: hinder or prevent the progress or accomplishment of?
Or sense 3: stop from happening or developing?
Or sense 6: interrupt the normal function of by means of anesthesia? No, not anesthesia.
Let's check sense 2: "hinder or prevent the progress or accomplishment of" - synonyms: obstruct, blockade, hinder, stymie, stymy, embarrass. Example: His brother blocked him at every turn.
Wait, "blocks the activity" -> prevents the activity from happening.
Let's consider sense 2 vs sense 3.
Sense 3: stop from happening or developing. Examples: Block his election; Halt the process.
Sense 2: hinder or prevent the progress or accomplishment of.
Actually, in WordNet, "block" as in "block the activity" might be sense 2 or 3.
Let's look at "block" in the context of enzymes. "blocks the activity of the enzymes".
Is there a better fit?
What about sense 2: hinder or prevent the progress or accomplishment of.
What about sense 3: stop from happening or developing.
Let's search for "block the activity" in WordNet.
Wait, "block" meaning "hinder or prevent the progress or accomplishment of" (sense 2).
Let's check the examples for sense 2: "His brother blocked him at every turn".
Let's check sense 3: "Block his election; Halt the process".
"blocks the activity" -> stops the activity from happening.
Could it be sense 2? "hinder or prevent the progress or accomplishment of"
Let's consider "block" as in "block the action of".
In WordNet, "block" (verb) has:
- block, barricade, blockade, stop, block off, block up, bar (render unsuitable for passage)
- obstruct, blockade, hinder, stymie, stymy, embarrass (hinder or prevent the progress or accomplishment of)
- stop, halt, block, kibosh (stop from happening or developing)
- jam (interfere with or prevent the reception of signals)
- block (run on a block system)
- block (interrupt the normal function of by means of anesthesia)
- obstruct, block (shut out from view or get in the way so as to hide from sight)
- block (stamp or emboss a title or design on a book with a block)
- stuff, lug, choke up, block (obstruct)
- obstruct, obturate, impede, occlude, jam, close up, block (block passage through)
- block (support, secure, or raise with a block)
- parry, deflect, block (impede the movement of (an opponent or a ball))
- forget, blank out, draw a blank, block (be unable to remember)
- block (shape by using a block)
- block (shape into a block or blocks)
- freeze, immobilize, immobilise, block (prohibit the conversion or use of (assets))

"blocks the activity of the enzymes" -> stops the activity.
Is it sense 2 or sense 3?
"stop from happening or developing" (sense 3) -> "Block his election; Halt the process".
"hinder or prevent the progress or accomplishment of" (sense 2) -> "His brother blocked him at every turn".
"blocks the activity" is more like "stop from happening or developing" or "hinder or prevent the progress or accomplishment of".
Wait, "block" in "block the activity" is often mapped to "hinder or prevent the progress or accomplishment of" or "stop from happening or developing".
Let's look at similar examples. "block the action of a drug" -> hinder or prevent.
Actually, "block" in "block the activity" is often sense 2.
Let's re-read sense 2: "hinder or prevent the progress or accomplishment of".
Sense 3: "stop from happening or developing".
"blocks the activity" -> prevents the activity.
Let's consider "block" as in "block the activity of the enzymes".
Is there a sense for "inhibit"? No.
Let's choose sense 2. "hinder or prevent the progress or accomplishment of".
Wait, "stop from happening or developing" (sense 3) might be better for "activity". "Halt the process" is an example for sense 3. "Activity" is a process.
Let's check if there is a more specific sense.
What about sense 2? "hinder or prevent the progress or accomplishment of".
Let's look at the synonyms for sense 2: obstruct, blockade, hinder, stymie, stymy, embarrass.
Synonyms for sense 3: stop, halt, kibosh.
"blocks the activity" -> stops the activity.
I will guess sense 2 because "hinder or prevent the progress or accomplishment of" fits "blocks the activity" (preventing the enzymes from accomplishing their function).
Wait, "stop from happening or developing" (sense 3) has "Halt the process". Enzyme activity is a process.
Let's search my internal knowledge for "block the activity".
In WordNet, "block" (verb) sense 2: "hinder or prevent the progress or accomplishment of".
Sense 3: "stop from happening or developing".
I'll go with 2.
Wait, let's think if "block" in "block the activity" is sense 2.
"His brother blocked him at every turn" -> hinder.
"Block his election" -> stop.
"blocks the activity of the enzymes" -> prevents the activity.
I will choose 2.
Let's reconsider 2 vs 3.
"block" as in "block the action" is often sense 2.
Let's choose 2.
Wait, "block" in "block the activity" could be sense 2.
Let's check sense 2 again. "hinder or prevent the progress or accomplishment of".
Yes, "prevent the accomplishment of" fits "blocks the activity".
I'll output 2.
Let's double check.
"blocks the activity of the enzymes"
Could it be 2? Yes.
Could it be 3? "stop from happening or developing".
I'll go with 2.
Wait, "block" in medical contexts: "block the activity of the enzymes".
Is there a sense "inhibit"? No.
I'll output 2.
Let's review the options.
1. render unsuitable for passage
2. hinder or prevent the progress or accomplishment of
3. stop from happening or developing
4. interfere with or prevent the reception of signals
5. run on a block system
6. interrupt the normal function of by means of anesthesia
7. shut out from view
8. stamp or emboss
9. obstruct (stuff, choke up)
10. block passage through
11. support, secure, or raise with a block
12. impede the movement of
13. be unable to remember
14. shape by using a block
15. shape into a block or blocks
16. prohibit the conversion or use of (assets)

"blocks the activity" -> prevents the activity. Sense 2: "hinder or prevent the progress or accomplishment of".
I will use 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: involved
Target surface form: involved
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=involved%3:00:00:: | definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved; the problems involved
2. sense_key=involved%5:00:00:encumbered:00 | definition=entangled or hindered as if e.g. in mire | synonyms=mired | examples=the difficulties in which the question is involved; brilliant leadership mired in details and confusion
3. sense_key=involved%5:00:00:attached:01 | definition=emotionally involved
4. sense_key=involved%5:00:00:complex:00 | definition=highly complex or intricate and occasionally devious; ; ; ; ; ; ; ; - Sir Walter Scott | synonyms=Byzantine, convoluted, knotty, tangled, tortuous | examples=the Byzantine tax structure; Byzantine methods for holding on to his chairmanship
5. sense_key=involved%5:00:00:enclosed:00 | definition=enveloped | examples=a castle involved in mist; the difficulties in which the question is involved

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "involved".
Context: "...blocks the activity of the enzymes that are involved in producing nucleotides..."
Meaning: The enzymes participate in or are associated with the process of producing nucleotides.
Candidate senses:
1. connected by participation or association or use (e.g., people involved, problems involved)
2. entangled or hindered
3. emotionally involved
4. highly complex or intricate
5. enveloped

Sense 1 fits perfectly: "connected by participation or association or use". The enzymes participate in producing nucleotides.
Let's double check.
"enzymes that are involved in producing nucleotides" -> enzymes that participate in producing nucleotides.
Sense 1: connected by participation or association or use.
Yes, sense 1 is the best fit.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: produce
Target surface form: producing
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in <t>producing</t> nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=produce%2:36:02:: | definition=bring forth or yield | synonyms=bring forth | examples=The tree would not produce fruit
2. sense_key=produce%2:36:00:: | definition=create or manufacture a man-made product | synonyms=make, create | examples=We produce more cars than we can sell; The company has been making toys for two centuries
3. sense_key=produce%2:36:03:: | definition=cause to happen, occur or exist | synonyms=bring about, give rise | examples=This procedure produces a curious effect; The new law gave rise to many complaints
4. sense_key=produce%2:39:01:: | definition=bring out for display | synonyms=bring forth | examples=The proud father produced many pictures of his baby; The accused brought forth a letter in court that he claims exonerates him
5. sense_key=produce%2:36:05:: | definition=cultivate by growing, often involving improvements by means of agricultural techniques | synonyms=grow, raise, farm | examples=The Bordeaux region produces great red wines; They produce good ham in Parma
6. sense_key=produce%2:39:00:: | definition=bring onto the market or release | synonyms=bring on, bring out | examples=produce a movie; bring out a book
7. sense_key=produce%2:29:00:: | definition=come to have or undergo a change of (physical features and attributes) | synonyms=grow, develop, get, acquire | examples=He grew a beard; The patient developed abdominal pains

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "producing" in the context: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."
The enzymes are involved in creating or manufacturing nucleotides.
Let's look at the candidate senses:
1. bring forth or yield (e.g., tree producing fruit)
2. create or manufacture a man-made product (make, create) - wait, nucleotides are biological, but "create or manufacture" fits the idea of synthesizing. Let's check other senses.
3. cause to happen, occur or exist (bring about, give rise)
4. bring out for display
5. cultivate by growing, often involving improvements by means of agricultural techniques
6. bring onto the market or release
7. come to have or undergo a change of

Wait, "create or manufacture a man-made product" is sense 2. But nucleotides are not man-made.
Let's re-read sense 1: "bring forth or yield" (The tree would not produce fruit).
Is there a better sense?
Let's check WordNet for "produce" in the sense of synthesizing or creating.
Sense 2: "create or manufacture a man-made product" - synonyms: make, create. Examples: We produce more cars than we can sell; The company has been making toys for two centuries.
Wait, "produce" in biology: "produce nucleotides".
Is it sense 1 or sense 2?
Let's look at sense 1: "bring forth or yield".
Let's look at sense 2: "create or manufacture a man-made product".
Wait, WordNet sense 2 is "create or manufacture a man-made product". But maybe it's just "create or manufacture".
Let's check sense 1: "bring forth or yield".
Let's check sense 3: "cause to happen, occur or exist".
Let's check sense 2 again. "create or manufacture a man-made product".
Is there a sense for "synthesize"?
Let's search WordNet for "produce" meaning "synthesize".
produce%2:36:02:: bring forth or yield
produce%2:36:00:: create or manufacture a man-made product
produce%2:36:03:: cause to happen, occur or exist
produce%2:36:05:: cultivate by growing
produce%2:39:01:: bring out for display
produce%2:39:00:: bring onto the market or release
produce%2:29:00:: come to have or undergo a change of

Wait, "producing nucleotides" -> creating or manufacturing. Even though nucleotides are not man-made, the sense "create or manufacture" is the closest to "synthesize".
Let's consider "bring forth or yield" (sense 1). "The tree would not produce fruit". Enzymes produce nucleotides.
Actually, in WordNet, "produce" meaning "create or manufacture" is often used for biological synthesis too, or maybe "bring forth or yield" is better?
Let's look at the synonyms for sense 2: make, create.
"Enzymes that are involved in creating nucleotides" -> "make, create".
"Enzymes that are involved in bringing forth or yielding nucleotides" -> "bring forth or yield".
"Enzymes that are involved in causing to happen nucleotides" -> no.
"Enzymes that are involved in making nucleotides" -> yes.
So sense 2 is the best fit because "make, create" are the synonyms, and "producing nucleotides" means making/creating them.
Let's double check if there's any other sense.
Sense 1: bring forth or yield.
Sense 2: create or manufacture a man-made product. (The gloss says "man-made", but the synonyms are "make, create").
Is there a sense for "generate"?
Let's check the exact WordNet entry for produce.
produce v.
1. bring forth or yield (The tree would not produce fruit)
2. create or manufacture a man-made product (We produce more cars than we can sell; The company has been making toys for two centuries)
3. cause to happen, occur or exist (This procedure produces a curious effect; The new law gave rise to many complaints)
4. bring out for display (The proud father produced many pictures of his baby)
5. cultivate by growing (The Bordeaux region produces great red wines)
6. bring onto the market or release (produce a movie)
7. come to have or undergo a change of (He grew a beard)

If the gloss says "man-made product", does it strictly apply?
"create or manufacture a man-made product"
But "make, create" are the synonyms.
"producing nucleotides" = making nucleotides.
I will choose sense 2.
Wait, let's think if "bring forth or yield" (sense 1) is better for biological processes. "The body produces antibodies." "The tree produces fruit."
"Enzymes that are involved in producing nucleotides" -> making nucleotides.
Let's search for "produce nucleotides" in WordNet or similar.
Actually, "create or manufacture" fits "synthesizing" (making).
Let's consider "bring forth or yield". "Yield" is often used for crops or results.
"Make, create" is used for manufacturing or synthesizing.
I'll go with 2.
Wait, let's re-read the gloss for 2: "create or manufacture a man-made product".
Is nucleotide a man-made product? No.
But maybe sense 1 is "bring forth or yield", which applies to natural things like trees producing fruit, bodies producing antibodies, enzymes producing nucleotides.
Let's check the examples for sense 1: "The tree would not produce fruit".
Enzymes producing nucleotides is very similar to a tree producing fruit (a natural biological process of bringing forth/yielding).
Wait, "make" is a synonym for sense 2. "Enzymes involved in making nucleotides".
Let's look at sense 1 synonyms: bring forth.
"Enzymes involved in bringing forth nucleotides" - sounds a bit odd.
"Enzymes involved in creating nucleotides" - sounds better.
Let's check if there is a sense "generate". No.
What about "produce" as in "generate"?
In WordNet, "generate" is a separate verb.
Let's consider "create or manufacture a man-made product". The "man-made" part might be a restrictive gloss, but "make, create" are the core synonyms.
Let's look at another example: "The body produces heat." -> cause to happen? Or bring forth?
"The body produces antibodies." -> bring forth or yield?
Actually, many annotators map biological synthesis to "create or manufacture" (sense 2) because it's about making something.
Let's search my internal knowledge for "produce nucleotides" WordNet sense.
"produce" in the sense of "synthesize" is often mapped to "create or manufacture" (sense 2) or "bring forth or yield" (sense 1).
Let's look at the synonyms of sense 2: make, create.
"Enzymes that are involved in making nucleotides" -> this is perfectly natural.
"Enzymes that are involved in bringing forth nucleotides" -> less natural.
I will bet on sense 2 because "make, create" are the synonyms and "producing" here means "synthesizing/making".
Wait, could it be sense 1? "bring forth or yield".
Let's check the definition of sense 1: "bring forth or yield".
Definition of sense 2: "create or manufacture a man-made product".
If the gloss explicitly says "man-made product", an annotator might avoid it for nucleotides.
But "make, create" are the synonyms.
Let's consider "bring forth or yield". "Yield" can mean to produce as a result of a process.
"Enzymes that are involved in yielding nucleotides" - no.
"Enzymes that are involved in creating nucleotides" - yes.
I will choose 2.
Let's reconsider. What if it's 1?
"produce" (biology) -> bring forth or yield.
Example: "The tree would not produce fruit."
Fruit is biological. Nucleotides are biological.
So sense 1 might be the intended one for biological production.
But "make" is sense 2.
Let's look at the exact wording of sense 2: "create or manufacture a man-made product".
If the gloss says "man-made", it might be a trap.
Is there a sense "generate"? No.
Let's look at sense 1: "bring forth or yield".
Let's look at sense 3: "cause to happen, occur or exist".
Let's look at sense 7: "come to have or undergo a change of".
I think sense 2 is the most appropriate for "synthesizing" or "making" a chemical compound, despite the "man-made" in the gloss, because "make, create" are the synonyms.
Wait, let's search for "produce" + "enzyme" in WordNet examples. None.
What about "produce" + "DNA"?
Let's guess sense 2. "create or manufacture" -> "make, create".
Actually, "produce" in the sense of "synthesize" is often sense 2.
Let's choose 2.
Wait, let's think if "bring forth or yield" is better.
"bring forth" is more like giving birth or bearing fruit.
"create or manufacture" is more like building or synthesizing.
Enzymes synthesize (build) nucleotides. So "create or manufacture" (make, create) is the best fit.
I will go with 2.
Let's double check.
"producing nucleotides" -> making nucleotides.
Synonyms for 2: make, create.
Yes, 2 is the best.