[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: problem
Target surface form: problems
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney <t>problems</t>. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=problem%1:26:00:: | definition=a state of difficulty that needs to be resolved | synonyms=job | examples=she and her husband are having problems; it is always a job to contact him
2. sense_key=problem%1:10:00:: | definition=a question raised for consideration or solution | examples=our homework consisted of ten problems to solve
3. sense_key=problem%1:09:00:: | definition=a source of difficulty | synonyms=trouble | examples=one trouble after another delayed the job; what's the problem?

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context is about medical treatment with Alimta. The sentence says "Alimta is not recommended for use in patients with moderate or severe kidney problems." Here, "problems" refers to kidney issues/difficulties - a medical condition or source of difficulty. This aligns with sense 1 (a state of difficulty that needs to be resolved) or sense 3 (a source of difficulty).

Sense 1: "a state of difficulty that needs to be resolved" - synonyms include "job"
Sense 3: "a source of difficulty" - synonyms include "trouble"

In medical context, "kidney problems" refers to kidney troubles/issues - a source of difficulty. Sense 3 seems most appropriate as it captures the meaning of "trouble" or medical issues. The example "what's the problem?" also fits well with the medical context where problems refer to health issues.

Actually, let me reconsider. Sense 1 talks about "a state of difficulty that needs to be resolved" which could also fit medical problems. But sense 3 "a source of difficulty" with synonym "trouble" fits better with "kidney problems" meaning kidney troubles/issues.

I'll go with sense 3.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: more
Target surface form: more
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For <t>more</t> information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=more%3:00:01:: | definition=(comparative of `much' used with mass nouns) a quantifier meaning greater in size or amount or extent or degree | synonyms=more than | examples=more land; more support
2. sense_key=more%3:00:02:: | definition=(comparative of `many' used with count nouns) quantifier meaning greater in number | examples=a hall with more seats; we have no more bananas

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

finish_reason: stop

role: assistant

reasoning_content:
The target word "more" appears in the phrase "For more information, see the Summary of Product Characteristics."

In this context, "more" is used to mean "additional" or "further." It's a quantifier used with a mass noun ("information" is uncountable/mass).

Looking at the candidate senses:
1. sense_key=more%3:00:01:: | definition=(comparative of `much' used with mass nouns) a quantifier meaning greater in size or amount or extent or degree
2. sense_key=more%3:00:02:: | definition=(comparative of `many' used with count nouns) quantifier meaning greater in number

"Information" is a mass noun (uncountable), so sense 1 is the better fit. The meaning is "additional information" — greater in amount of information.

format: unknown

native_finish_reason: stop

provider: Minimax

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: information
Target surface form: information
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more <t>information</t>, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=information%1:10:00:: | definition=a message received and understood | synonyms=info
2. sense_key=information%1:09:00:: | definition=knowledge acquired through study or experience or instruction
3. sense_key=information%1:10:02:: | definition=formal accusation of a crime
4. sense_key=information%1:14:00:: | definition=a collection of facts from which conclusions may be drawn | synonyms=data | examples=statistical data
5. sense_key=information%1:07:00:: | definition=(communication theory) a numerical measure of the uncertainty of an outcome | synonyms=selective information, entropy | examples=the signal contained thousands of bits of information

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word "information" appears in the context: "For more information, see the Summary of Product Characteristics (also part of the EPAR)."

This is a common phrase "For more information" which refers to additional details/facts that can be obtained. Let me consider the candidate senses:

1. "a message received and understood" - synonyms: info
2. "knowledge acquired through study or experience or instruction"
3. "formal accusation of a crime" - not relevant
4. "a collection of facts from which conclusions may be drawn" - synonyms: data
5. "(communication theory) a numerical measure of the uncertainty of an outcome" - not relevant

The phrase "For more information" typically refers to additional facts/details that can be accessed. This is closest to sense 1 (a message received and understood) or sense 4 (a collection of facts).

In WordNet, sense 1 (information%1:10:00::) is defined as "a message received and understood" with synonym "info". This is the general, everyday sense of information as something communicated/received.

Sense 4 is more about statistical data or a collection of facts from which conclusions may be drawn.

"For more information, see the Summary of Product Characteristics" - this is pointing to additional details/facts that can be read. This is the general informational sense, which aligns with sense 1.

Actually, let me reconsider. In WordNet's hierarchy:
- Sense 1 (1:10:00) is "a message received and understood" - this is the general communication sense
- Sense 4 (1:14:00) is "a collection of facts from which conclusions may be drawn" - more like data

The phrase "For more information" in a document context typically means "for more details/facts." This could be either sense, but sense 1 is the most common general usage.

I'll go with sense 1.

provider: Parasail


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: see
Target surface form: see
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=see%2:39:00:: | definition=perceive by sight or have the power to perceive by sight | examples=You have to be a good observer to see all the details; Can you see the bird in that tree?
2. sense_key=see%2:31:01:: | definition=perceive (an idea or situation) mentally | synonyms=understand, realize, realise | examples=Now I see!; I just can't see your point
3. sense_key=see%2:39:02:: | definition=perceive or be contemporaneous with | synonyms=witness, find | examples=We found Republicans winning the offices; You'll see a lot of cheating in this school
4. sense_key=see%2:36:00:: | definition=imagine; conceive of; see in one's mind | synonyms=visualize, visualise, envision, project, fancy, figure | examples=I can't see him on horseback!; I can see what will happen
5. sense_key=see%2:31:00:: | definition=deem to be | synonyms=consider, reckon, view, regard | examples=She views this quite differently from me; I consider her to be shallow
6. sense_key=see%2:31:02:: | definition=get to know or become aware of, usually accidentally | synonyms=learn, hear, get word, get wind, pick up, find out | examples=I learned that she has two grown-up children; I see that you have been promoted
7. sense_key=see%2:39:03:: | definition=see or watch | synonyms=watch, view, catch, take in | examples=view a show on television; This program will be seen all over the world
8. sense_key=see%2:38:00:: | definition=come together | synonyms=meet, run into, encounter, run across, come across | examples=I'll probably see you at the meeting; How nice to see you again!
9. sense_key=see%2:32:00:: | definition=find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, find out, ascertain, watch, learn | examples=I want to see whether she speaks French; See whether it works
10. sense_key=see%2:31:03:: | definition=be careful or certain to do something; make certain of something | synonyms=check, insure, see to it, ensure, control, ascertain | examples=He verified that the valves were closed; See that the curtains are closed
11. sense_key=see%2:41:11:: | definition=go to see for professional or business reasons | examples=You should see a lawyer; We had to see a psychiatrist
12. sense_key=see%2:41:12:: | definition=go to see for a social visit | examples=I went to see my friend Mary the other day
13. sense_key=see%2:41:10:: | definition=go to see a place, as for entertainment | synonyms=visit | examples=We went to see the Eiffel Tower in the morning
14. sense_key=see%2:41:14:: | definition=take charge of or deal with | synonyms=attend, take care, look | examples=Could you see about lunch?; I must attend to this matter
15. sense_key=see%2:35:09:: | definition=receive as a specified guest | examples=the doctor will see you now; The minister doesn't see anybody before noon
16. sense_key=see%2:41:00:: | definition=date regularly; have a steady relationship with | synonyms=go steady, go out, date | examples=Did you know that she is seeing an older man?; He is dating his former wife again!
17. sense_key=see%2:39:05:: | definition=see and understand, have a good eye | examples=The artist must first learn to see
18. sense_key=see%2:31:08:: | definition=deliberate or decide | examples=See whether you can come tomorrow; let's see--which movie should we see tonight?
19. sense_key=see%2:39:11:: | definition=observe as if with an eye | examples=The camera saw the burglary and recorded it
20. sense_key=see%2:39:13:: | definition=observe, check out, and look over carefully or inspect | synonyms=examine | examples=The customs agent examined the baggage; I must see your passport before you can enter the country
21. sense_key=see%2:39:12:: | definition=go or live through | synonyms=experience, go through | examples=We had many trials to go through; he saw action in Viet Nam
22. sense_key=see%2:38:03:: | definition=accompany or escort | synonyms=escort | examples=I'll see you to the door
23. sense_key=see%2:33:00:: | definition=match or meet | examples=I saw the bet of one of my fellow players
24. sense_key=see%2:31:13:: | definition=make sense of; assign a meaning to | synonyms=interpret, construe | examples=What message do you see in this letter?; How do you interpret his behavior?

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context is: "For more information, see the Summary of Product Characteristics (also part of the EPAR)."

Here, "see" means "consult" or "refer to" - the reader is being directed to look at or refer to a specific document for more information. This is essentially meaning "to look at" or "to consult."

Looking at the candidate senses:

1. sense_key=see%2:39:00:: - "perceive by sight or have the power to perceive by sight" - This is the physical act of seeing, but doesn't quite capture the "refer to" meaning.

20. sense_key=see%2:39:13:: - "observe, check out, and look over carefully or inspect" - This has "check out" as a synonym which is closer to "consult for information."

6. sense_key=see%2:31:02:: - "get to know or become aware of, usually accidentally" - This is more about learning something.

The usage "For more information, see X" is a standard reference/consultation sense. Let me think about this more carefully.

In WordNet, the "see" in "see reference" typically maps to sense 1 (see%2:39:00) - perceiving by sight - or to sense 20 (see%2:39:13) - observe, check out, look over carefully or inspect.

Actually, looking at this more carefully, the phrase "For more information, see [document]" is essentially telling the reader to look at or consult that document. The most appropriate sense would be sense 20 (see%2:39:13) - "observe, check out, and look over carefully or inspect" - because the reader is being directed to check/consult a reference document.

However, sense 1 (perceive by sight) is also a candidate since the reader is being asked to look at something with their eyes.

Hmm, let me think about which is the best fit. The "see" here means "consult" or "refer to" - which is about looking something up for information purposes. This is closer to sense 20 which includes "check out" as a synonym.

Actually, in many WordNet analyses, the "see" in bibliographic/reference contexts is often mapped to sense 20 (see%2:39:13). The "check out" synonym fits well with the consultation meaning.

I'll go with sense 20.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: product
Target surface form: Product
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=product%1:06:01:: | definition=commodities offered for sale | synonyms=merchandise, ware | examples=good business depends on having good merchandise; that store offers a variety of products
2. sense_key=product%1:06:00:: | definition=an artifact that has been created by someone or some process | synonyms=production | examples=they improve their product every year; they export most of their agricultural production
3. sense_key=product%1:09:00:: | definition=a quantity obtained by multiplication | synonyms=mathematical product | examples=the product of 2 and 3 is 6
4. sense_key=product%1:27:00:: | definition=a chemical substance formed as a result of a chemical reaction | examples=a product of lime and nitric acid
5. sense_key=product%1:19:00:: | definition=a consequence of someone's efforts or of a particular set of circumstances | examples=skill is the product of hours of practice; his reaction was the product of hunger and fatigue
6. sense_key=product%1:14:00:: | definition=the set of elements common to two or more sets | synonyms=intersection, Cartesian product | examples=the set of red hats is the intersection of the set of hats and the set of red things

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word "Product" appears in the phrase "Summary of Product Characteristics." This is a well-known regulatory/pharmaceutical term referring to a document that describes the properties and effects of a medicinal product (in this case, the drug Alimta).

Let me think about which sense fits best:

1. "commodities offered for sale" - merchandise/ware
2. "an artifact that has been created by someone or some process" - production
3. "a quantity obtained by multiplication" - mathematical product
4. "a chemical substance formed as a result of a chemical reaction"
5. "a consequence of someone's efforts or of a particular set of circumstances"
6. "the set of elements common to two or more sets" - intersection/Cartesian product

In the context of pharmaceutical regulation, "Product" in "Summary of Product Characteristics" refers to the medicinal product itself - the drug that has been created/produced. This is sense 2: "an artifact that has been created by someone or some process." The SmPC is a document describing the properties of a specific pharmaceutical product (drug), which is an artifact created through a manufacturing/development process.

Sense 1 (commodities for sale) could also be considered, but the SmPC is more about describing the technical properties of the drug product rather than its commercial aspect.

Sense 2 is the best fit - the pharmaceutical product is an artifact created by a process (drug development and manufacturing).

provider: Novita


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: part
Target surface form: part
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=part%1:24:00:: | definition=something determined in relation to something that includes it | synonyms=portion, component part, component, constituent | examples=he wanted to feel a part of something bigger than himself; I read a portion of the manuscript
2. sense_key=part%1:06:00:: | definition=something less than the whole of a human artifact | synonyms=portion | examples=the rear part of the house; glue the two parts together
3. sense_key=part%1:17:00:: | definition=a portion of a natural object | synonyms=piece | examples=they analyzed the river into three parts; he needed a piece of granite
4. sense_key=part%1:09:02:: | definition=that which concerns a person with regard to a particular role or situation | examples=it requires vigilance on our part; they resisted every effort on his part
5. sense_key=part%1:15:00:: | definition=the extended spatial location of something | synonyms=region | examples=the farming regions of France; religions in all parts of the world
6. sense_key=part%1:04:01:: | definition=the actions and activities assigned to or required or expected of a person or group | synonyms=function, office, role | examples=the function of a teacher; the government must do its part
7. sense_key=part%1:09:01:: | definition=an actor's portrayal of someone in a play | synonyms=character, role, theatrical role, persona | examples=she played the part of Desdemona
8. sense_key=part%1:21:00:: | definition=assets belonging to or due to or contributed by an individual person or group | synonyms=share, portion, percentage | examples=he wanted his share in cash
9. sense_key=part%1:09:00:: | definition=one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division | examples=the written part of the exam; the finance section of the company
10. sense_key=part%1:08:01:: | definition=a line of scalp that can be seen when sections of hair are combed in opposite directions | synonyms=parting | examples=his part was right in the middle
11. sense_key=part%1:10:00:: | definition=the melody carried by a particular voice or instrument in polyphonic music | synonyms=voice | examples=he tried to sing the tenor part
12. sense_key=part%1:04:03:: | definition=the part played by a person in bringing about a result | synonyms=contribution, share | examples=I am proud of my contribution in advancing the project; they all did their share of the work

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word "part" appears in the context: "For more information, see the Summary of Product Characteristics (also part of the EPAR)."

Here, "part" is used to indicate that the Summary of Product Characteristics is a component/portion of the EPAR (European Public Assessment Report). The EPAR is a larger document, and the Summary of Product Characteristics is a part/component of it.

Let me look at the candidate senses:

1. "something determined in relation to something that includes it" - synonyms: portion, component part, component, constituent. Examples: "he wanted to feel a part of something bigger than himself; I read a portion of the manuscript"
2. "something less than the whole of a human artifact" - synonyms: portion. Examples: "the rear part of the house; glue the two parts together"
3. "a portion of a natural object" - synonyms: piece
4. "that which concerns a person with regard to a particular role or situation"
5. "the extended spatial location of something" - region
6. "the actions and activities assigned to or required or expected of a person or group" - function, office, role
7. "an actor's portrayal of someone in a play" - character, role, theatrical role, persona
8. "assets belonging to or due to or contributed by an individual person or group" - share, portion, percentage
9. "one of the portions into which something is regarded as divided and which together constitute a whole" - section, division
10. "a line of scalp that can be seen when sections of hair are combed in opposite directions" - parting
11. "the melody carried by a particular voice or instrument in polyphonic music" - voice
12. "the part played by a person in bringing about a result" - contribution, share

The EPAR is a document, which is a human artifact. The Summary of Product Characteristics is a section/component of the EPAR document.

Sense 2 talks about "something less than the whole of a human artifact" with examples like "the rear part of the house" and "glue the two parts together."

Sense 9 talks about "one of the portions into which something is regarded as divided and which together constitute a whole" with examples like "the written part of the exam" and "the finance section of the company."

Sense 1 is more about something determined in relation to something that includes it, with the example "he wanted to feel a part of something bigger than himself."

In this context, "part of the EPAR" means the Summary of Product Characteristics is a component/section of the EPAR document. The EPAR is a human artifact (a document), and the Summary of Product Characteristics is a portion/part of that document.

Sense 2 seems most appropriate because the EPAR is a human artifact (a document), and the Summary of Product Characteristics is "something less than the whole of" that artifact.

Sense 9 could also work - "one of the portions into which something is regarded as divided" - the EPAR is divided into multiple sections including the Summary of Product Characteristics.

Hmm, let me think more carefully. Sense 1 emphasizes the relationship "determined in relation to something that includes it" - this seems to fit well for "part of the EPAR" where the EPAR includes the SPC.

Actually, looking more carefully:
- Sense 1: "something determined in relation to something that includes it" - this is about the conceptual relationship of being included in something larger
- Sense 2: "something less than the whole of a human artifact" - this is specifically about a portion of a human-made object
- Sense 9: "one of the portions into which something is regarded as divided" - this is about a section/division

The EPAR is a document (human artifact), and the SPC is one of its sections. The phrase "part of the EPAR" here means the SPC is a section/component of the EPAR document.

I think Sense 2 fits well because the EPAR is explicitly a human artifact (a document/assessment report), and the SPC is a portion of it.

Sense 9 also fits - "one of the portions into which something is regarded as divided" - the EPAR is divided into several parts, one of which is the SPC.

The distinction is subtle. Sense 2 emphasizes "human artifact" specifically, while Sense 9 is more general about divisions.

Given that the EPAR is a human-made document, Sense 2 seems most appropriate. The example "glue the two parts together" suggests physical parts, but the gloss "something less than the whole of a human artifact" fits the SPC being part of the EPAR document.

Actually, I'll go with Sense 2 because the EPAR is a human artifact (a regulatory document), and the SPC is literally a part/portion of that document.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
7. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
13. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word "active" appears in the context: "pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides"

The preceding sentence also mentions "The active substance in Alimta, pemetrexed..." which uses "active" in the sense of "active ingredient" (sense 6: exerting influence or producing a change or effect).

However, the specific occurrence of "active" that is tagged is in "an active form" - referring to the converted form of pemetrexed. This means the form that is exerting influence/effect, i.e., the form that is pharmacologically active.

Looking at the candidate senses:
- Sense 6: "exerting influence or producing a change or effect" with example "an active ingredient" - this fits well because the "active form" is the form that produces the effect (blocking enzyme activity).
- Sense 1: "tending to become more severe or wider in scope" - doesn't fit
- Sense 8: "in operation" - could fit but the example uses "alive" and the context is about a specific form

Sense 6 seems most appropriate. The "active form" in pharmacology refers to the form of the drug that is producing its intended effect. This aligns with "exerting influence or producing a change or effect."

Wait, but the first "active" in the context ("The active substance in Alimta") is also tagged? Let me re-read. The target is the second "active" in the context? Actually, looking again, the target form is "active" and the context shows "<t>active</t> substance" - so the tagged word is "active" modifying "substance."

"The active substance in Alimta, pemetrexed, is a cytotoxic medicine..."

This is the classic "active ingredient" usage. The active substance is the one that exerts the therapeutic effect. This perfectly matches sense 6: "exerting influence or producing a change or effect" with example "an active ingredient."

So the answer is sense 6.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: substance
Target surface form: substance
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=substance%1:03:00:: | definition=the real physical matter of which a person or thing consists | examples=DNA is the substance of our genes
2. sense_key=substance%1:09:01:: | definition=the choicest or most essential or most vital part of some idea or experience | synonyms=kernel, core, center, centre, essence, gist | examples=the gist of the prosecutor's argument; the heart and soul of the Republican Party
3. sense_key=substance%1:09:00:: | definition=the idea that is intended | synonyms=meaning | examples=What is the meaning of this proverb?
4. sense_key=substance%1:27:00:: | definition=material of a particular kind or constitution | examples=the immune response recognizes invading substances
5. sense_key=substance%1:21:00:: | definition=considerable capital (wealth or income) | synonyms=means | examples=he is a man of means
6. sense_key=substance%1:10:00:: | definition=what a communication that is about something is about | synonyms=message, content, subject matter
7. sense_key=substance%1:03:01:: | definition=a particular kind or species of matter with uniform properties | examples=shigella is one of the most toxic substances known to man

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context is about the active substance in a medicine (Alimta/pemetrexed). "The active substance in Alimta, pemetrexed, is a cytotoxic medicine..." Here, "substance" refers to the chemical compound that is the active ingredient. This is a material/chemical substance.

Looking at the candidates:
- Sense 1: "the real physical matter of which a person or thing consists" - this is more about the physical matter composing something
- Sense 4: "material of a particular kind or constitution" - this fits well for a chemical substance/ingredient
- Sense 7: "a particular kind or species of matter with uniform properties" - this also fits as pemetrexed is a particular kind of matter

Between sense 4 and sense 7, sense 7 seems more specific to a particular kind of chemical/matter with uniform properties, which fits "pemetrexed" as a specific chemical substance. However, sense 4 is about "material of a particular kind or constitution" which also fits.

In pharmaceutical contexts, "active substance" typically refers to the chemical compound. Sense 7 with "a particular kind or species of matter with uniform properties" seems to match best, as pemetrexed is a specific chemical entity.

Actually, let me reconsider. Sense 1 is "the real physical matter of which a person or thing consists" - example: "DNA is the substance of our genes." This could also fit, as pemetrexed is the substance of the medicine.

But in common pharmaceutical terminology, "active substance" refers to the specific chemical compound. Sense 7 "a particular kind or species of matter with uniform properties" is the most precise match for a named chemical compound.

I'll go with sense 7.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The target word "medicine" in the context refers to pemetrexed, which is described as "a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells)". This is clearly referring to a medication/drug that treats disease, which matches sense 2: "something that treats or prevents or alleviates the symptoms of disease" with synonyms "medication, medicament, medicinal drug".


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word "medicine" appears in the context: "a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells)". This is clearly referring to a substance/drug that treats disease. The parenthetical definition "a medicine that kills cells that are dividing" confirms this is about a pharmaceutical substance.

Looking at the candidate senses:
1. medical specialty - not relevant
2. medication, medicament, medicinal drug - this matches perfectly
3. practice of medicine - not relevant
4. punishment - not relevant

The answer is sense 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: kill
Target surface form: kills
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=kill%2:35:00:: | definition=cause to die; put to death, usually intentionally or knowingly | examples=This man killed several people when he tried to rob a bank; The farmer killed a pig for the holidays
2. sense_key=kill%2:41:01:: | definition=thwart the passage of | synonyms=shoot down, defeat, vote down, vote out | examples=kill a motion; he shot down the student's proposal
3. sense_key=kill%2:30:08:: | definition=end or extinguish by forceful means | synonyms=stamp out | examples=Stamp out poverty!
4. sense_key=kill%2:42:00:: | definition=be fatal | examples=cigarettes kill; drunken driving kills
5. sense_key=kill%2:39:00:: | definition=be the source of great pain for | examples=These new shoes are killing me!
6. sense_key=kill%2:37:00:: | definition=overwhelm with hilarity, pleasure, or admiration | examples=The comedian was so funny, he was killing me!
7. sense_key=kill%2:35:06:: | definition=hit with so much force as to make a return impossible, in racket games | examples=She killed the ball
8. sense_key=kill%2:35:05:: | definition=hit with great force | examples=He killed the ball
9. sense_key=kill%2:35:02:: | definition=deprive of life | examples=AIDS has killed thousands in Africa
10. sense_key=kill%2:35:01:: | definition=cause the death of, without intention | examples=She was killed in the collision of three cars
11. sense_key=kill%2:34:00:: | definition=drink down entirely | synonyms=toss off, pop, bolt down, belt down, pour down, down | examples=He downed three martinis before dinner; She killed a bottle of brandy that night
12. sense_key=kill%2:30:00:: | definition=mark for deletion, rub off, or erase | synonyms=obliterate, wipe out | examples=kill these lines in the President's speech
13. sense_key=kill%2:30:04:: | definition=tire out completely | examples=The daily stress of her work is killing her
14. sense_key=kill%2:30:03:: | definition=cause to cease operating | examples=kill the engine
15. sense_key=kill%2:30:02:: | definition=destroy a vitally essential quality of or in | examples=Eating artichokes kills the taste of all other foods

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context is about a cytotoxic medicine that "kills cells that are dividing, such as cancer cells." This refers to causing the death of cells. Let me look at the candidate senses.

Sense 1: "cause to die; put to death, usually intentionally or knowingly" - This is about killing people/animals intentionally.
Sense 9: "deprive of life" - This is more general about causing death.
Sense 10: "cause the death of, without intention" - Without intention.

The medicine kills cancer cells - this is causing the death of cells. It's not really "intentional" in the human sense, but the medicine is designed to kill cells. Sense 9 "deprive of life" seems most appropriate as it's a general sense about causing death/life deprivation. Sense 1 is more about intentional killing of people/animals. Sense 10 is about unintentional death.

Actually, looking more carefully, the medicine is designed to kill cells - it's a deliberate action by the medicine. Sense 1 says "usually intentionally or knowingly" which could apply. But sense 9 "deprive of life" is more general and fits the biological context of killing cells.

Hmm, let me think again. The examples for sense 1 are about killing people and pigs. Sense 9's example is "AIDS has killed thousands" which is more about disease causing death. The medicine killing cancer cells is similar to a disease/agent causing death of cells.

Sense 9 seems best - "deprive of life" - because it's about causing death in a more general/biological sense, similar to how AIDS kills people.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cells
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context talks about "cells that are dividing, such as cancer cells" and "the building blocks of DNA and RNA, the genetic material of cells." This is clearly referring to biological cells.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: divide
Target surface form: dividing
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=divide%2:41:00:: | definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire after World War I
2. sense_key=divide%2:31:00:: | definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven?
3. sense_key=divide%2:42:00:: | definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries
4. sense_key=divide%2:35:00:: | definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated
5. sense_key=divide%2:38:00:: | definition=make a division or separation | synonyms=separate
6. sense_key=divide%2:35:01:: | definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output: {"sense_index": 1}{"sense_index": 1}

content: {"sense_index": 1}{"sense_index": 1}

reasoning_content:
The target word is "dividing" in the context: "a medicine that kills cells that are dividing, such as cancer cells"

This refers to the biological process of cell division. The context is about pemetrexed being a cytotoxic medicine that kills cells that are in the process of dividing (reproducing/mitosis).

Looking at the candidate senses:
1. separate into parts or portions - This is about dividing something into parts
2. perform a division (arithmetic) - This is about mathematical division
3. act as a barrier between - about geographic/political division
4. come apart - about things separating
5. make a division or separation - general
6. force, take, or pull apart - about physically separating things

Hmm, none of these directly capture "cell division" in the biological sense. But let me think about which is closest.

"dividing" in the context of cells means cells that are undergoing mitosis/cell division - reproducing, splitting into daughter cells. This is closest to sense 4 "come apart" (separate, part) or sense 1 "separate into parts or portions" (split, split up, separate).

Cell division is essentially a cell splitting into parts (two daughter cells). Sense 1 talks about "split" and "separate" - "divide the cake into three equal parts" - this is about one thing being split into multiple parts, which is what happens in cell division.

Sense 4 is "come apart" which suggests things that were together separating - more passive.

Sense 1 seems more apt because cell division is an active process where one cell divides (splits) into two or more parts. The synonym "split" fits well with cell division.

Actually, in WordNet, biological cell division is typically covered by a specific sense. Let me reconsider. The sense 1 with "split" and "separate" seems most applicable to cell division - the cell is splitting/separating into parts (daughter cells).

I'll go with sense 1.

provider: AtlasCloud


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: divide
Target surface form: dividing
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=divide%2:41:00:: | definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire after World War I
2. sense_key=divide%2:31:00:: | definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven?
3. sense_key=divide%2:42:00:: | definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries
4. sense_key=divide%2:35:00:: | definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated
5. sense_key=divide%2:38:00:: | definition=make a division or separation | synonyms=separate
6. sense_key=divide%2:35:01:: | definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

[Assistant] {"sense_index": 1}{"sense_index": 1}

[User] Your previous answer was invalid. Choose one candidate index between 1 and 6. Return only valid JSON exactly like {"sense_index": 1}.

content: {"sense_index": 1}{"sense_index": 1}

reasoning_content: The context is about cells that are "dividing" - meaning cells that are undergoing cell division (mitosis). The definition "separate into parts or portions" fits best here, as cell division is the process by which a cell separates into parts.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: body
Target surface form: body
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=body%1:08:00:: | definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
2. sense_key=body%1:14:00:: | definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium; the student body
3. sense_key=body%1:08:02:: | definition=a natural object consisting of a dead animal or person | synonyms=dead body | examples=they found the body in the lake
4. sense_key=body%1:17:00:: | definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. sense_key=body%1:08:01:: | definition=the body excluding the head and neck and limbs | synonyms=torso, trunk | examples=they moved their arms and legs and bodies
6. sense_key=body%1:14:02:: | definition=a collection of particulars considered as a system | examples=a body of law; a body of doctrine
7. sense_key=body%1:07:00:: | definition=the property of holding together and retaining its shape | synonyms=consistency, consistence, eubstance | examples=wool has more body than rayon; when the dough has enough consistency it is ready to bake
8. sense_key=body%1:10:00:: | definition=the central message of a communication | examples=the body of the message was short
9. sense_key=body%1:07:01:: | definition=the main mass of a thing
10. sense_key=body%1:06:01:: | definition=a resonating chamber in a musical instrument (as the body of a violin) | synonyms=soundbox
11. sense_key=body%1:06:00:: | definition=the external structure of a vehicle | examples=the body of the car was badly rusted

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context is about a medicine (Alimta/pemetrexed) and how it works in the body. The sentence "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes..." refers to the human body as the entire organism's structure where the medicine acts. This matches sense 1: "the entire structure of an organism (an animal, plant, or human being)".


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: convert
Target surface form: converted
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=convert%2:30:00:: | definition=change from one system to another or to a new plan or policy | synonyms=change over | examples=We converted from 220 to 110 Volt
2. sense_key=convert%2:30:03:: | definition=change the nature, purpose, or function of something | examples=convert lead into gold; convert hotels into jails
3. sense_key=convert%2:30:01:: | definition=change religious beliefs, or adopt a religious belief | examples=She converted to Buddhism
4. sense_key=convert%2:30:02:: | definition=exchange or replace with another, usually of the same kind or category | synonyms=change, exchange, commute | examples=Could you convert my dollars into pounds?; He changed his name
5. sense_key=convert%2:30:07:: | definition=cause to adopt a new or different faith | examples=The missionaries converted the Indian population
6. sense_key=convert%2:33:02:: | definition=score an extra point or points after touchdown by kicking the ball through the uprights or advancing the ball into the end zone | examples=Smith converted and his team won
7. sense_key=convert%2:33:01:: | definition=complete successfully | examples=score a penalty shot or free throw
8. sense_key=convert%2:33:00:: | definition=score (a spare)
9. sense_key=convert%2:32:00:: | definition=make (someone) agree, understand, or realize the truth or validity of something | synonyms=win over, convince | examples=He had finally convinced several customers of the advantages of his product
10. sense_key=convert%2:30:09:: | definition=exchange a penalty for a less severe one | synonyms=commute, exchange
11. sense_key=convert%2:30:04:: | definition=change in nature, purpose, or function; undergo a chemical change | examples=The substance converts to an acid

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context is about pemetrexed being "converted into an active form" in the body. This is a chemical/biological transformation where one substance changes into another form. Looking at the candidate senses:

- Sense 2: "change the nature, purpose, or function of something" - examples include "convert lead into gold; convert hotels into jails"
- Sense 11: "change in nature, purpose, or function; undergo a chemical change" - examples include "The substance converts to an acid"

Sense 11 specifically mentions chemical change and has an example about a substance converting to an acid, which is very similar to pemetrexed being converted into an active form. This is the best match.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
7. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
13. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output: {"sense_index": 6}{"sense_index": 6}

content: {"sense_index": 6}{"sense_index": 6}

reasoning_content:
The context is about a drug (Alimta/pemetrexed). The sentence says: "pemetrexed is converted into an active form that blocks the activity of the enzymes..."

Here, "active form" refers to a form that exerts influence or produces an effect. This matches sense 6: "exerting influence or producing a change or effect" with the example "an active ingredient."

The "active form" of a drug is the form that is pharmacologically active, producing an effect. This is very close to the "active ingredient" example.

Sense 6 (active%3:00:07::) is the best match.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
7. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
13. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

[Assistant] {"sense_index": 6}{"sense_index": 6}

[User] Your previous answer was invalid. Choose one candidate index between 1 and 14. Return only valid JSON exactly like {"sense_index": 1}.

content: {"sense_index": 6}{"sense_index": 6}

reasoning_content: The context is: "pemetrexed is converted into an active form that blocks the activity of the enzymes..." Here, "active" refers to an "active ingredient" type meaning - exerting influence or producing a change or effect. The example given for sense 6 is "an active ingredient" which matches this pharmaceutical context perfectly.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: form
Target surface form: form
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=form%1:10:00:: | definition=the phonological or orthographic sound or appearance of a word that can be used to describe or identify something | synonyms=word form, signifier, descriptor | examples=the inflected forms of a word can be represented by a stem and a list of inflections to be attached
2. sense_key=form%1:09:01:: | definition=a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety | examples=sculpture is a form of art; what kinds of desserts are there?
3. sense_key=form%1:09:00:: | definition=a perceptual structure | synonyms=shape, pattern | examples=the composition presents problems for students of musical form; a visual pattern must include not only objects but the spaces between them
4. sense_key=form%1:07:01:: | definition=any spatial attributes (especially as defined by outline) | synonyms=shape, configuration, contour, conformation | examples=he could barely make out their shapes
5. sense_key=form%1:08:00:: | definition=alternative names for the body of a human being | synonyms=human body, physical body, material body, soma, build, figure | examples=Leonardo studied the human body; he has a strong physique
6. sense_key=form%1:03:00:: | definition=the spatial arrangement of something as distinct from its substance | synonyms=shape | examples=geometry is the mathematical science of shape
7. sense_key=form%1:07:00:: | definition=the visual appearance of something or someone | synonyms=shape, cast | examples=the delicate cast of his features
8. sense_key=form%1:10:01:: | definition=a printed document with spaces in which to write | examples=he filled out his tax form
9. sense_key=form%1:14:02:: | definition=(biology) a group of organisms within a species that differ in trivial ways from similar groups | synonyms=variant, strain, var. | examples=a new strain of microorganisms
10. sense_key=form%1:10:02:: | definition=an arrangement of the elements in a composition or discourse | examples=the essay was in the form of a dialogue; he first sketches the plot in outline form
11. sense_key=form%1:07:03:: | definition=a particular mode in which something is manifested | examples=his resentment took the form of extreme hostility
12. sense_key=form%1:26:00:: | definition=(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary | synonyms=phase | examples=the reaction occurs in the liquid phase of the system
13. sense_key=form%1:14:00:: | definition=a body of students who are taught together | synonyms=class, grade, course | examples=early morning classes are always sleepy
14. sense_key=form%1:07:02:: | definition=an ability to perform well | examples=he was at the top of his form; the team was off form last night
15. sense_key=form%1:06:00:: | definition=a life-size dummy used to display clothes | synonyms=mannequin, manikin, mannikin, manakin
16. sense_key=form%1:06:01:: | definition=a mold for setting concrete | examples=they built elaborate forms for pouring the foundation

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output: {"sense_index": 11}{"sense_index": 11}

content: {"sense_index": 11}{"sense_index": 11}

reasoning_content:
The target word "form" appears in the context: "the active substance in Alimta, pemetrexed, is a cytotoxic medicine... In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes..."

Here, "form" refers to a particular state or manifestation of the substance - a chemical form. Looking at the candidate senses:

- Sense 11: "a particular mode in which something is manifested" with example "his resentment took the form of extreme hostility" - this seems close but it's more about psychological manifestations.
- Sense 12: "(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary" with synonym "phase" - this is about distinct states of matter.

In chemistry, "active form" of a drug refers to the specific chemical state or molecular configuration. Sense 12 is about physical chemistry and phases. Sense 11 is about a "particular mode in which something is manifested."

The "active form" of pemetrexed is the converted, metabolically active form of the drug. This is about a particular state/manifestation of the chemical. Sense 12 talks about a "distinct state of matter" and "phase" - this seems more technical and chemistry-specific.

Sense 11 talks about a "particular mode in which something is manifested" - this is more general.

In pharmacology, "active form" of a prodrug refers to the metabolite that is pharmacologically active. This is essentially a different chemical state/form. Sense 12 seems most appropriate as it deals with physical chemistry states. However, sense 11 also fits well.

Let me think more carefully. The "active form" here means the active chemical species after conversion. This is essentially about a distinct chemical state/phase. Sense 12 specifically references physical chemistry and "phase" as a synonym. Sense 11 is more about how something is manifested or appears.

Given the scientific/chemistry context, sense 12 (phase, distinct state of matter) seems most fitting. The "active form" of pemetrexed is the active chemical state.

Wait, but actually "form" in "active form" in pharmacology/chemistry typically refers to the specific molecular or ionic state. Sense 12 talks about "identical in chemical composition" - but the active form of pemetrexed is a different chemical entity (it has different composition after conversion). So sense 12 might not be perfect.

Sense 11: "a particular mode in which something is manifested" - the active form is a particular mode/manifestation of pemetrexed. This could fit.

Sense 2: "a category of things distinguished by some common characteristic or quality" - the active form is a kind of form, but this doesn't quite capture it.

I think sense 11 is the best fit. "A particular mode in which something is manifested" - the active form is a particular mode in which pemetrexed exists after conversion. The example "his resentment took the form of extreme hostility" shows how something abstract takes a particular form.

Actually, re-reading sense 12: "a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary" - this specifically says "identical in chemical composition" which doesn't match since the active form of pemetrexed has different chemical composition than the prodrug.

So sense 12 is not quite right. Sense 11 is the best match - the active form is a particular mode/manifestation of the drug.

I'll go with sense 11.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: form
Target surface form: form
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=form%1:10:00:: | definition=the phonological or orthographic sound or appearance of a word that can be used to describe or identify something | synonyms=word form, signifier, descriptor | examples=the inflected forms of a word can be represented by a stem and a list of inflections to be attached
2. sense_key=form%1:09:01:: | definition=a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety | examples=sculpture is a form of art; what kinds of desserts are there?
3. sense_key=form%1:09:00:: | definition=a perceptual structure | synonyms=shape, pattern | examples=the composition presents problems for students of musical form; a visual pattern must include not only objects but the spaces between them
4. sense_key=form%1:07:01:: | definition=any spatial attributes (especially as defined by outline) | synonyms=shape, configuration, contour, conformation | examples=he could barely make out their shapes
5. sense_key=form%1:08:00:: | definition=alternative names for the body of a human being | synonyms=human body, physical body, material body, soma, build, figure | examples=Leonardo studied the human body; he has a strong physique
6. sense_key=form%1:03:00:: | definition=the spatial arrangement of something as distinct from its substance | synonyms=shape | examples=geometry is the mathematical science of shape
7. sense_key=form%1:07:00:: | definition=the visual appearance of something or someone | synonyms=shape, cast | examples=the delicate cast of his features
8. sense_key=form%1:10:01:: | definition=a printed document with spaces in which to write | examples=he filled out his tax form
9. sense_key=form%1:14:02:: | definition=(biology) a group of organisms within a species that differ in trivial ways from similar groups | synonyms=variant, strain, var. | examples=a new strain of microorganisms
10. sense_key=form%1:10:02:: | definition=an arrangement of the elements in a composition or discourse | examples=the essay was in the form of a dialogue; he first sketches the plot in outline form
11. sense_key=form%1:07:03:: | definition=a particular mode in which something is manifested | examples=his resentment took the form of extreme hostility
12. sense_key=form%1:26:00:: | definition=(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary | synonyms=phase | examples=the reaction occurs in the liquid phase of the system
13. sense_key=form%1:14:00:: | definition=a body of students who are taught together | synonyms=class, grade, course | examples=early morning classes are always sleepy
14. sense_key=form%1:07:02:: | definition=an ability to perform well | examples=he was at the top of his form; the team was off form last night
15. sense_key=form%1:06:00:: | definition=a life-size dummy used to display clothes | synonyms=mannequin, manikin, mannikin, manakin
16. sense_key=form%1:06:01:: | definition=a mold for setting concrete | examples=they built elaborate forms for pouring the foundation

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

[Assistant] {"sense_index": 11}{"sense_index": 11}

[User] Your previous answer was invalid. Choose one candidate index between 1 and 16. Return only valid JSON exactly like {"sense_index": 1}.

content: {"sense_index": 11}{"sense_index": 11}

reasoning_content:
The context: "pemetrexed is converted into an active form that blocks the activity of the enzymes..."

Here "form" refers to a particular mode/state/manifestation in which something exists. Sense 11: "a particular mode in which something is manifested" - this fits well. The example "his resentment took the form of extreme hostility" shows the same pattern: "X takes the form of Y" or "X is converted into an active form."

Sense 12 is about physical chemistry phase, which is more specific to states of matter.

Sense 11 is the best match.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: block
Target surface form: blocks
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=block%2:35:00:: | definition=render unsuitable for passage | synonyms=barricade, blockade, stop, block off, block up, bar | examples=block the way; barricade the streets
2. sense_key=block%2:41:00:: | definition=hinder or prevent the progress or accomplishment of | synonyms=obstruct, blockade, hinder, stymie, stymy, embarrass | examples=His brother blocked him at every turn
3. sense_key=block%2:41:01:: | definition=stop from happening or developing | synonyms=stop, halt, kibosh | examples=Block his election; Halt the process
4. sense_key=block%2:32:00:: | definition=interfere with or prevent the reception of signals | synonyms=jam | examples=Jam the Voice of America; block the signals emitted by this station
5. sense_key=block%2:41:03:: | definition=run on a block system | examples=block trains
6. sense_key=block%2:39:05:: | definition=interrupt the normal function of by means of anesthesia | examples=block a nerve; block a muscle
7. sense_key=block%2:39:00:: | definition=shut out from view or get in the way so as to hide from sight | synonyms=obstruct | examples=The thick curtain blocked the action on the stage; The trees obstruct my view of the mountains
8. sense_key=block%2:35:03:: | definition=stamp or emboss a title or design on a book with a block | examples=block the book cover
9. sense_key=block%2:35:02:: | definition=obstruct | synonyms=stuff, lug, choke up | examples=My nose is all stuffed; Her arteries are blocked
10. sense_key=block%2:35:12:: | definition=block passage through | synonyms=obstruct, obturate, impede, occlude, jam, close up | examples=obstruct the path
11. sense_key=block%2:35:06:: | definition=support, secure, or raise with a block | examples=block a plate for printing; block the wheels of a car
12. sense_key=block%2:33:00:: | definition=impede the movement of (an opponent or a ball) | synonyms=parry, deflect | examples=block an attack
13. sense_key=block%2:31:00:: | definition=be unable to remember | synonyms=forget, blank out, draw a blank | examples=I'm drawing a blank; You are blocking the name of your first wife!
14. sense_key=block%2:30:01:: | definition=shape by using a block | examples=Block a hat; block a garment
15. sense_key=block%2:30:00:: | definition=shape into a block or blocks | examples=block the graphs so one can see the results clearly
16. sense_key=block%2:30:02:: | definition=prohibit the conversion or use of (assets) | synonyms=freeze, immobilize, immobilise | examples=Blocked funds; Freeze the assets of this hostile government

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context is about pemetrexed blocking the activity of enzymes. This is about preventing the function of an enzyme. Looking at the candidate senses:

- Sense 6: "interrupt the normal function of by means of anesthesia" - this is about anesthesia, not enzymes
- Sense 2: "hinder or prevent the progress or accomplishment of" - generic hindering
- Sense 3: "stop from happening or developing" - stopping something
- Sense 4: "interfere with or prevent the reception of signals" - about signals
- Sense 9: "obstruct" with example "Her arteries are blocked" - this is about physical obstruction
- Sense 10: "block passage through" - about passage
- Sense 12: "impede the movement of" - about movement

The context: "blocks the activity of the enzymes" - this is about stopping/preventing the function of enzymes.

Sense 3 "stop from happening or developing" seems most fitting, as the enzyme's activity is being stopped/prevented. The synonyms "stop, halt, kibosh" fit well here - the drug stops the enzyme from working.

Actually, let me reconsider. Sense 2 is "hinder or prevent the progress or accomplishment of" which could also fit. But sense 3 is more about stopping something from happening/continuing, which is what blocking enzyme activity does.

Sense 4 is about signals specifically.

Sense 6 is specifically about anesthesia, not relevant.

I think sense 3 is the best fit - the drug blocks (stops) the activity of the enzymes, preventing them from functioning.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: involved
Target surface form: involved
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=involved%3:00:00:: | definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved; the problems involved
2. sense_key=involved%5:00:00:encumbered:00 | definition=entangled or hindered as if e.g. in mire | synonyms=mired | examples=the difficulties in which the question is involved; brilliant leadership mired in details and confusion
3. sense_key=involved%5:00:00:attached:01 | definition=emotionally involved
4. sense_key=involved%5:00:00:complex:00 | definition=highly complex or intricate and occasionally devious; ; ; ; ; ; ; ; - Sir Walter Scott | synonyms=Byzantine, convoluted, knotty, tangled, tortuous | examples=the Byzantine tax structure; Byzantine methods for holding on to his chairmanship
5. sense_key=involved%5:00:00:enclosed:00 | definition=enveloped | examples=a castle involved in mist; the difficulties in which the question is involved

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word "involved" appears in the context: "the enzymes that are involved in producing nucleotides."

This means the enzymes participate in or are connected to the process of producing nucleotides. The meaning is about being connected by participation or association.

Looking at the candidate senses:
1. "connected by participation or association or use" - This fits perfectly. The enzymes are involved (participate) in producing nucleotides.
2. "entangled or hindered as if e.g. in mire" - Doesn't fit; this is about being stuck or hindered.
3. "emotionally involved" - Doesn't fit; not about emotions.
4. "highly complex or intricate" - Doesn't fit; not about complexity.
5. "enveloped" - Doesn't fit; not about being surrounded.

The answer is sense 1.