[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: produce
Target surface form: producing
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in <t>producing</t> nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=produce%2:36:02:: | definition=bring forth or yield | synonyms=bring forth | examples=The tree would not produce fruit
2. sense_key=produce%2:36:00:: | definition=create or manufacture a man-made product | synonyms=make, create | examples=We produce more cars than we can sell; The company has been making toys for two centuries
3. sense_key=produce%2:36:03:: | definition=cause to happen, occur or exist | synonyms=bring about, give rise | examples=This procedure produces a curious effect; The new law gave rise to many complaints
4. sense_key=produce%2:39:01:: | definition=bring out for display | synonyms=bring forth | examples=The proud father produced many pictures of his baby; The accused brought forth a letter in court that he claims exonerates him
5. sense_key=produce%2:36:05:: | definition=cultivate by growing, often involving improvements by means of agricultural techniques | synonyms=grow, raise, farm | examples=The Bordeaux region produces great red wines; They produce good ham in Parma
6. sense_key=produce%2:39:00:: | definition=bring onto the market or release | synonyms=bring on, bring out | examples=produce a movie; bring out a book
7. sense_key=produce%2:29:00:: | definition=come to have or undergo a change of (physical features and attributes) | synonyms=grow, develop, get, acquire | examples=He grew a beard; The patient developed abdominal pains

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context is about pemetrexed blocking enzymes involved in producing nucleotides. Here, "producing" refers to the biological process of generating/creating nucleotides. Let me consider the candidate senses:

1. "bring forth or yield" - This is about natural generation, like trees producing fruit. Nucleotides are naturally generated by enzymes, so this could fit.
2. "create or manufacture a man-made product" - This is about man-made manufacturing, not natural biological processes.
3. "cause to happen, occur or exist" - This is more about causing effects or events.
4. "bring out for display" - Not relevant here.
5. "cultivate by growing" - Agricultural, not relevant.
6. "bring onto the market" - Not relevant.
7. "come to have or undergo a change of (physical features and attributes)" - About growth/development, not relevant.

The context says "enzymes that are involved in producing nucleotides" - enzymes naturally generate (bring forth/yield) nucleotides as part of biological processes. Sense 1 "bring forth or yield" fits best here, as the enzymes naturally produce/generate nucleotides in the body.

Sense 3 "cause to happen, occur or exist" could also be a candidate but it seems more about causing events or effects rather than the direct generation of a substance.

Sense 1 is the best fit because the enzymes are directly generating/bringing forth nucleotides.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: building_block
Target surface form: building blocks
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the <t>building blocks</t> of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=building_block%1:17:00:: | definition=a single undivided natural thing occurring in the composition of something else | synonyms=unit | examples=units of nucleic acids
2. sense_key=building_block%1:06:00:: | definition=a block of material used in construction work

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

finish_reason: stop

role: assistant

reasoning_content: The context is about nucleotides being "the building blocks of DNA and RNA." This refers to nucleotides as fundamental units that compose DNA and RNA. Sense 1 matches this with its definition "a single undivided natural thing occurring in the composition of something else" and example "units of nucleic acids." Sense 2 is about physical construction blocks, which doesn't fit.

format: unknown

native_finish_reason: stop

provider: Minimax

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: genetic
Target surface form: genetic
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the <t>genetic</t> material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=genetic%5:00:00:inheritable:00 | definition=occurring among members of a family usually by heredity | synonyms=familial, hereditary, inherited, transmitted, transmissible | examples=an inherited disease; familial traits
2. sense_key=genetic%3:01:02:: | definition=of or relating to or produced by or being a gene | synonyms=genic, genetical | examples=genic combinations; genetic code
3. sense_key=genetic%3:01:01:: | definition=pertaining to or referring to origin | examples=genetic history reconstructs the origins of a literary work
4. sense_key=genetic%3:01:00:: | definition=of or relating to the science of genetics | synonyms=genetical | examples=genetic research

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context is about DNA and RNA as "the genetic material of cells." This refers to genetic material, which is about genes and DNA. Let me look at the candidate senses:

1. sense_key=genetic%5:00:00:inheritable:00 - pertaining to inheritance/family
2. sense_key=genetic%3:01:02:: - of or relating to or produced by or being a gene
3. sense_key=genetic%3:01:01:: - pertaining to origin
4. sense_key=genetic%3:01:00:: - of or relating to the science of genetics

"Genetic material" in the context of DNA and RNA building blocks clearly refers to the gene-related sense. Sense 2 (of or relating to or produced by or being a gene) is the best fit here, as "genetic material" refers to the material that makes up genes (DNA/RNA).

Sense 2 it is.

provider: Novita


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: material
Target surface form: material
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic <t>material</t> of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=material%1:27:00:: | definition=the tangible substance that goes into the makeup of a physical object | synonyms=stuff | examples=coal is a hard black material; wheat is the stuff they use to make bread
2. sense_key=material%1:10:00:: | definition=information (data or ideas or observations) that can be used or reworked into a finished form | examples=the archives provided rich material for a definitive biography
3. sense_key=material%1:06:00:: | definition=artifact made by weaving or felting or knitting or crocheting natural or synthetic fibers | synonyms=fabric, cloth, textile | examples=the fabric in the curtains was light and semitransparent; woven cloth originated in Mesopotamia around 5000 BC
4. sense_key=material%1:06:01:: | definition=things needed for doing or making something | examples=writing materials; useful teaching materials
5. sense_key=material%1:18:00:: | definition=a person judged suitable for admission or employment | examples=he was university material; she was vice-presidential material

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word "material" appears in the context: "the building blocks of DNA and RNA, the genetic material of cells."

Here, "genetic material" refers to the physical substance that makes up DNA and RNA - the tangible substance that constitutes the genetic information. This is about the physical/chemical substance itself.

Let me consider the candidate senses:

1. "the tangible substance that goes into the makeup of a physical object" - This fits well. DNA and RNA are tangible substances that make up the genetic component of cells.

2. "information (data or ideas or observations) that can be used or reworked into a finished form" - This could also fit since genetic material carries information. However, the context emphasizes "building blocks" and the physical substance aspect.

3. Fabric/cloth - doesn't fit.

4. Things needed for doing or making something - doesn't fit.

5. A person judged suitable - doesn't fit.

Between 1 and 2, the context says "the building blocks of DNA and RNA, the genetic material of cells." The phrase "building blocks" emphasizes the physical substance aspect. DNA and RNA are described as the genetic material - referring to the actual molecular substance. While genetic material does carry information, in this context it's being described as a tangible substance (building blocks).

Sense 1 seems most appropriate - "the tangible substance that goes into the makeup of a physical object." DNA and RNA are tangible substances that make up cells.

Actually, let me reconsider. "Genetic material" is a technical term that refers to the substance (DNA/RNA) that carries genetic information. The context is explaining that DNA and RNA are the "genetic material" - meaning the physical substance. The "building blocks" metaphor emphasizes the physical substance nature.

I'll go with sense 1.

provider: Parasail


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cells
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of <t>cells</t>). How has Alimta been studied?

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context discusses biological cells - cancer cells, cells as units with DNA and RNA. This is clearly the biological sense.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: study
Target surface form: studied
Context:
Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been <t>studied</t>? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before.

Candidate senses:
1. sense_key=study%2:31:02:: | definition=consider in detail and subject to an analysis in order to discover essential features or meaning | synonyms=analyze, analyse, examine, canvass, canvas | examples=analyze a sonnet by Shakespeare; analyze the evidence in a criminal trial
2. sense_key=study%2:31:03:: | definition=be a student; follow a course of study; be enrolled at an institute of learning
3. sense_key=study%2:39:00:: | definition=give careful consideration to | synonyms=consider | examples=consider the possibility of moving
4. sense_key=study%2:31:00:: | definition=be a student of a certain subject | synonyms=learn, read, take | examples=She is reading for the bar exam
5. sense_key=study%2:31:01:: | definition=learn by reading books | synonyms=hit the books | examples=He is studying geology in his room; I have an exam next week; I must hit the books now
6. sense_key=study%2:31:04:: | definition=think intently and at length, as for spiritual purposes | synonyms=meditate, contemplate | examples=He is meditating in his study

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context is about how a medicine (Alimta) has been researched/investigated in clinical trials. "Studied" here means "investigated" or "examined in detail through research."

Looking at the candidate senses:

1. sense_key=study%2:31:02:: | definition=consider in detail and subject to an analysis in order to discover essential features or meaning | synonyms=analyze, analyse, examine, canvass, canvas
2. sense_key=study%2:31:03:: | definition=be a student; follow a course of study; be enrolled at an institute of learning
3. sense_key=study%2:39:00:: | definition=give careful consideration to | synonyms=consider
4. sense_key=study%2:31:00:: | definition=be a student of a certain subject | synonyms=learn, read, take
5. sense_key=study%2:31:01:: | definition=learn by reading books | synonyms=hit the books
6. sense_key=study%2:31:04:: | definition=think intently and at length, as for spiritual purposes | synonyms=meditate, contemplate

The context is about clinical research/trials - "Alimta has been studied in one main study in 456 patients." This means the medicine was investigated/researched/examined in a clinical trial.

Sense 1 is about "consider in detail and subject to an analysis in order to discover essential features or meaning" with synonyms like analyze, examine. This fits well because "studied" in a clinical trial context means the medicine was examined/analyzed through research.

Sense 3 is "give careful consideration to" which is more general.

Sense 1 seems the best match because clinical studies involve detailed analysis and examination of the medicine's effects. The synonym "examine" fits perfectly with how medicines are "studied" in clinical trials.

Wait, let me reconsider. The sense numbers in WordNet - sense 1 here has key study%2:31:02:: which is a verb sense. The "2:31" indicates it's a verb of "investigation" (cognition).

Actually, for clinical trials, "studied" could also map to a specific sense. Let me look again:

Sense 1: "consider in detail and subject to an analysis in order to discover essential features or meaning" - analyze, examine
Sense 3: "give careful consideration to" - consider

The clinical study involves detailed analysis to discover essential features (efficacy, safety). Sense 1 fits well.

I'll go with sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: treatment
Target surface form: treatment
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the <t>treatment</t> of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=treatment%1:04:00:: | definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) | synonyms=intervention
2. sense_key=treatment%1:04:01:: | definition=the management of someone or something | synonyms=handling | examples=the handling of prisoners; the treatment of water sewage
3. sense_key=treatment%1:07:00:: | definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture
4. sense_key=treatment%1:10:00:: | definition=an extended communication (often interactive) dealing with some particular topic | synonyms=discussion, discourse | examples=the book contains an excellent discussion of modal logic; his treatment of the race question is badly biased

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context is about a medicine (Alimta/pemetrexed) used for the treatment of malignant pleural mesothelioma. This is clearly about medical care provided to improve a situation, specifically medical procedures intended to relieve illness. This matches sense 1: "care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)" with synonym "intervention".


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: study
Target surface form: studied
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been <t>studied</t> in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=study%2:31:02:: | definition=consider in detail and subject to an analysis in order to discover essential features or meaning | synonyms=analyze, analyse, examine, canvass, canvas | examples=analyze a sonnet by Shakespeare; analyze the evidence in a criminal trial
2. sense_key=study%2:31:03:: | definition=be a student; follow a course of study; be enrolled at an institute of learning
3. sense_key=study%2:39:00:: | definition=give careful consideration to | synonyms=consider | examples=consider the possibility of moving
4. sense_key=study%2:31:00:: | definition=be a student of a certain subject | synonyms=learn, read, take | examples=She is reading for the bar exam
5. sense_key=study%2:31:01:: | definition=learn by reading books | synonyms=hit the books | examples=He is studying geology in his room; I have an exam next week; I must hit the books now
6. sense_key=study%2:31:04:: | definition=think intently and at length, as for spiritual purposes | synonyms=meditate, contemplate | examples=He is meditating in his study

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context is about how Alimta has been "studied" in clinical trials - meaning it has been researched/investigated in clinical studies. This is the sense of "consider in detail and subject to an analysis in order to discover essential features or meaning" - which corresponds to sense 1 (analyze, examine).

Let me look at the candidate senses more carefully:

1. sense_key=study%2:31:02:: | definition=consider in detail and subject to an analysis in order to discover essential features or meaning | synonyms=analyze, analyse, examine, canvass, canvas
2. sense_key=study%2:31:03:: | definition=be a student; follow a course of study; be enrolled at an institute of learning
3. sense_key=study%2:39:00:: | definition=give careful consideration to | synonyms=consider
4. sense_key=study%2:31:01:: | definition=learn by reading books | synonyms=hit the books
5. sense_key=study%2:31:04:: | definition=think intently and at length, as for spiritual purposes | synonyms=meditate, contemplate
6. sense_key=study%2:31:00:: | definition=be a student of a certain subject | synonyms=learn, read, take

The context is about clinical research - "Alimta has been studied in one main study in 456 patients." This means the drug was investigated/researched/analyzed in clinical trials. This best matches sense 1: "consider in detail and subject to an analysis in order to discover essential features or meaning" with synonyms analyze, examine.

The answer is sense_index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: main
Target surface form: main
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one <t>main</t> study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=main%5:00:00:important:00 | definition=most important element | synonyms=chief, primary, principal, master | examples=the chief aim of living; the main doors were of solid glass
2. sense_key=main%3:00:02:: | definition=(of a clause) capable of standing syntactically alone as a complete sentence | synonyms=independent | examples=the main (or independent) clause in a complex sentence has at least a subject and a verb
3. sense_key=main%5:00:00:intense:00 | definition=of force; of the greatest possible intensity | examples=by main strength

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The target word "main" appears in the context: "Alimta has been studied in one main study in 456 patients". Here, "main" means "primary" or "chief" — the most important or principal study. This matches sense 1: "most important element" with synonyms like chief, primary, principal, master.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: study
Target surface form: study
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main <t>study</t> in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=study%1:04:00:: | definition=a detailed critical inspection | synonyms=survey
2. sense_key=study%1:09:03:: | definition=applying the mind to learning and understanding a subject (especially by reading) | synonyms=work | examples=mastering a second language requires a lot of work; no schools offer graduate study in interior design
3. sense_key=study%1:10:00:: | definition=a written document describing the findings of some individual or group | synonyms=report, written report | examples=this accords with the recent study by Hill and Dale
4. sense_key=study%1:09:04:: | definition=a state of deep mental absorption | examples=she is in a deep study
5. sense_key=study%1:06:00:: | definition=a room used for reading and writing and studying | examples=he knocked lightly on the closed door of the study
6. sense_key=study%1:09:02:: | definition=a branch of knowledge | synonyms=discipline, subject, subject area, subject field, field, field of study | examples=in what discipline is his doctorate?; teachers should be well trained in their subject
7. sense_key=study%1:06:01:: | definition=preliminary drawing for later elaboration | synonyms=sketch | examples=he made several studies before starting to paint
8. sense_key=study%1:09:01:: | definition=attentive consideration and meditation | synonyms=cogitation | examples=after much cogitation he rejected the offer
9. sense_key=study%1:18:00:: | definition=someone who memorizes quickly and easily (as the lines for a part in a play) | examples=he is a quick study
10. sense_key=study%1:10:01:: | definition=a composition intended to develop one aspect of the performer's technique | examples=a study in spiccato bowing

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context is about a clinical trial/study of Alimta in 456 patients. The word "study" here refers to a research investigation or written document describing findings. Looking at the candidate senses:

- Sense 3: "a written document describing the findings of some individual or group" with synonyms "report, written report" - this fits well as clinical studies produce reports.
- Sense 1: "a detailed critical inspection" with synonym "survey" - this could also fit but is more about inspection.

In medical/clinical contexts, "study" typically refers to a research investigation, which aligns with sense 3 (a written document describing findings) or sense 1 (a detailed critical inspection).

Looking more carefully, sense 3 mentions "written document describing the findings" which matches how clinical studies are reported. The example "this accords with the recent study by Hill and Dale" is very similar to the context here.

Sense 1 is more about inspection/survey in general.

I think sense 3 is the best fit because clinical studies are typically documented research with findings reported.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 <t>patients</t> who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context is about a medical study involving 456 patients who had not received chemotherapy. This clearly refers to people who require medical care. Sense 1 is the correct choice.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: before
Target surface form: before
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease <t>before</t>. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=before%4:02:03:: | definition=earlier in time; previously | synonyms=earlier | examples=I had known her before; as I said before
2. sense_key=before%4:02:01:: | definition=at or in the front | synonyms=ahead, in front | examples=I see the lights of a town ahead; the road ahead is foggy

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word "before" appears in the context: "patients who had not received chemotherapy for their disease before."

This usage means "previously" or "earlier in time" - referring to a point in time before the study. This matches sense 1 (earlier in time; previously).

Sense 2 is about spatial position (in front, ahead), which doesn't fit the temporal context here.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: effect
Target surface form: effects
Context:
How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The <t>effects</t> of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past.

Candidate senses:
1. sense_key=effect%1:19:00:: | definition=a phenomenon that follows and is caused by some previous phenomenon | synonyms=consequence, outcome, result, event, issue, upshot | examples=the magnetic effect was greater when the rod was lengthwise; his decision had depressing consequences for business
2. sense_key=effect%1:07:00:: | definition=an outward appearance | synonyms=impression | examples=he made a good impression; I wanted to create an impression of success
3. sense_key=effect%1:09:00:: | definition=an impression (especially one that is artificial or contrived) | examples=he just did it for effect
4. sense_key=effect%1:10:00:: | definition=the central meaning or theme of a speech or literary work | synonyms=essence, burden, core, gist
5. sense_key=effect%1:07:01:: | definition=(of a law) having legal validity | synonyms=force | examples=the law is still in effect
6. sense_key=effect%1:26:00:: | definition=a symptom caused by an illness or a drug | examples=the effects of sleep loss; the effect of the anesthetic

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context is about a medicine (Alimta) and its effects when combined with cisplatin or compared with docetaxel. "The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone." This is about the results/outcomes of the medicine - what the medicine does or causes.

Looking at the candidate senses:
1. effect%1:19:00:: - a phenomenon that follows and is caused by some previous phenomenon (consequence, outcome, result)
6. effect%1:26:00:: - a symptom caused by an illness or a drug

Sense 6 specifically mentions "a symptom caused by an illness or a drug" with examples "the effects of sleep loss; the effect of the anesthetic." This seems very relevant to a medical context discussing drug effects.

However, sense 1 is about consequences/results/outcomes more generally. In the context of studying a medicine, "the effects of Alimta" could refer to either the therapeutic outcomes or the symptoms/side effects.

Looking more carefully at the context: "The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone." This is about comparing the therapeutic effects/outcomes of the treatment. In medical studies, "effects" typically refers to the outcomes/results of the treatment.

But sense 6 is specifically about "a symptom caused by an illness or a drug" - this could include both therapeutic effects and side effects. The example "the effect of the anesthetic" is about a drug's effect.

Actually, in medical/pharmaceutical contexts, "effects" of a drug typically refers to the consequences/outcomes of taking the drug, which aligns with sense 1 (consequence, outcome, result). Sense 6 is more narrow - specifically about symptoms.

Hmm, but sense 6 explicitly mentions "a drug" in its definition. Let me reconsider.

The context is from what appears to be a medical information document about Alimta. "The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone" - this is about the therapeutic outcomes/effects of the drug treatment.

Sense 1: "a phenomenon that follows and is caused by some previous phenomenon" - this is the general meaning of effect as consequence/result.
Sense 6: "a symptom caused by an illness or a drug" - this is more specific to medical symptoms.

In the context of comparing drug treatments, "effects" here refers to the outcomes/results of the treatment - how well it works, what it does. This is more aligned with sense 1 (consequence, outcome, result) than sense 6 (symptom).

However, sense 6's definition explicitly mentions "a drug" and the example "the effect of the anesthetic" is very similar to discussing drug effects.

I think sense 1 is the better fit here because:
- The context is about comparing therapeutic outcomes
- "Effects" here means results/outcomes of the treatment
- Sense 1's synonyms (consequence, outcome, result) fit better

But sense 6 could also work because it's specifically about drug effects.

Let me look at the examples again:
- Sense 1: "the magnetic effect was greater when the rod was lengthwise; his decision had depressing consequences for business"
- Sense 6: "the effects of sleep loss; the effect of the anesthetic"

The context "the effects of Alimta" is most similar to "the effect of the anesthetic" in sense 6. Both are about drugs/medicines and their effects.

Actually, I think sense 6 is the better choice here because:
1. It's specifically about drug effects
2. The example "the effect of the anesthetic" is structurally identical to "the effects of Alimta"
3. In medical contexts, "effects of a drug" typically refers to what the drug does to the body

Wait, but sense 6 says "a symptom caused by an illness or a drug" - this suggests it's about symptoms (which could include side effects or therapeutic effects). In the context of comparing drug treatments, the "effects" being compared are the therapeutic outcomes.

I'll go with sense 6 because it's specifically about drug effects and the example matches the context well.

Actually, let me reconsider once more. Sense 1 is about consequences/results/outcomes in general. Sense 6 is specifically about symptoms caused by drugs. In the context of a medical study comparing treatments, "the effects of Alimta" refers to the outcomes/results of the treatment - this is more about what the drug does (therapeutic effect) rather than symptoms per se.

Hmm, but "symptom caused by a drug" could include therapeutic effects. The distinction is subtle.

Looking at the structure: "The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone." This is comparing the outcomes of two treatments. The "effects" here are the results of the treatment.

I think sense 1 is the better fit because:
- It's about consequences/results/outcomes
- The context is about comparing treatment outcomes
- Sense 6 is more about symptoms (which could be side effects)

But sense 6 is specifically about drug effects, which is what we're discussing here.

I'll go with sense 6 because it's the most specific match for drug effects in a medical context.

Wait, let me look at this more carefully. The sense 6 definition says "a symptom caused by an illness or a drug." In medical terminology, "effects" of a drug can refer to both therapeutic effects and side effects. The example "the effect of the anesthetic" refers to the anesthetic's effect (making you unconscious), which is a therapeutic effect, not a symptom.

So sense 6 is about drug effects in general, not just side effects. This fits the context well.

I'll go with sense 6.

Actually, I want to reconsider one more time. Sense 1 is the most general sense of "effect" as consequence/result. Sense 6 is a specific medical sense. In the context of a medical document about a drug, sense 6 is more appropriate.

Final answer: sense 6.

Hmm, but let me think about this differently. The context is from what appears to be a European Medicines Agency (EMA) document about Alimta. In such documents, "effects" of a drug typically refers to the therapeutic outcomes/effects.

Sense 1: consequence, outcome, result - this is the general meaning
Sense 6: a symptom caused by an illness or a drug - this is the medical meaning

In a medical context discussing drug effects, sense 6 is more appropriate. The example "the effect of the anesthetic" is very similar to "the effects of Alimta."

I'll go with sense 6.

Wait, I need to be more careful. Let me re-read sense 6: "a symptom caused by an illness or a drug." The key word here is "symptom." A symptom is typically something negative or a sign of something. But drug effects can be therapeutic (positive) or side effects (negative).

In the context of comparing Alimta with cisplatin, the "effects" being compared are the therapeutic outcomes - how well the treatment works. This is more about outcomes/results than symptoms.

Hmm, this is tricky. Let me look at the examples again:
- Sense 1: "his decision had depressing consequences for business" - this is about consequences/results
- Sense 6: "the effects of sleep loss; the effect of the anesthetic" - these are about effects of specific conditions/drugs

The context "the effects of Alimta" is most similar to "the effect of the anesthetic" in sense 6. Both are about drugs and their effects.

I'll go with sense 6.

Actually, I realize I should think about this more carefully. The question is whether "effects of Alimta" in this context refers to:
(a) The therapeutic outcomes/results of taking Alimta (sense 1 - consequence/result)
(b) The symptoms/effects caused by Alimta (sense 6 - symptom caused by a drug)

In medical studies, when we compare "the effects of Alimta with cisplatin" vs "cisplatin alone," we're comparing the therapeutic outcomes. This is about what the treatment achieves (e.g., tumor shrinkage, survival).

But sense 6 is specifically about drug effects, and the example "the effect of the anesthetic" is about a drug's effect (making you unconscious).

I think sense 6 is the better fit because:
1. It's specifically about drug effects
2. The example matches the context structurally
3. In medical contexts, "effects of a drug" is a common phrase

Final answer: sense 6.

Hmm, but I'm not 100% sure. Let me think about this one more time.

Sense 1: "a phenomenon that follows and is caused by some previous phenomenon" - this is the general meaning of effect as consequence/result.
Sense 6: "a symptom caused by an illness or a drug" - this is the medical meaning.

In the context of a medical study, "the effects of Alimta" refers to what happens when you take Alimta - the outcomes/results. This could be interpreted as either sense 1 (general consequence) or sense 6 (drug effect).

The key difference is that sense 6 is specifically about symptoms (which can be positive or negative effects of a drug), while sense 1 is about any consequence/result.

In medical terminology, "effects of a drug" typically refers to the drug's actions on the body, which can include therapeutic effects and side effects. This aligns with sense 6.

I'll go with sense 6.

OK, final answer: sense 6.

Wait, I want to reconsider one more time. The context is:
"The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone."

This is comparing the effects of two treatments. The "effects" here are the outcomes of the treatments - how well they work. This is about consequences/results/outcomes.

Sense 1 is about consequences/results/outcomes.
Sense 6 is about symptoms caused by drugs.

In medical studies, when we compare the "effects" of two treatments, we're comparing their therapeutic outcomes. This is more about results/outcomes than symptoms.

But sense 6 is specifically about drug effects, which is what we're discussing.

I think both senses could apply, but sense 6 is more specific to the medical context. The example "the effect of the anesthetic" is very similar to "the effects of Alimta."

Final answer: sense 6.

OK let me just commit to sense 6. It's the most specific match for drug effects in a medical context.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: compare
Target surface form: compared
Context:
How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were <t>compared</t> with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past.

Candidate senses:
1. sense_key=compare%2:31:00:: | definition=examine and note the similarities or differences of | examples=John compared his haircut to his friend's; We compared notes after we had both seen the movie
2. sense_key=compare%2:42:00:: | definition=be comparable | examples=This car does not compare with our line of Mercedes
3. sense_key=compare%2:31:01:: | definition=consider or describe as similar, equal, or analogous | synonyms=liken, equate | examples=We can compare the Han dynasty to the Romans; You cannot equate success in financial matters with greed
4. sense_key=compare%2:32:00:: | definition=to form the comparative or superlative form on an adjective or adverb

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context is about clinical studies where the effects of Alimta in combination with cisplatin were "compared" with those of cisplatin alone. This is about examining and noting differences/similarities between two treatments. This matches sense 1: "examine and note the similarities or differences of."


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: treatment
Target surface form: treatment
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the <t>treatment</t> of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=treatment%1:04:00:: | definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) | synonyms=intervention
2. sense_key=treatment%1:04:01:: | definition=the management of someone or something | synonyms=handling | examples=the handling of prisoners; the treatment of water sewage
3. sense_key=treatment%1:07:00:: | definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture
4. sense_key=treatment%1:10:00:: | definition=an extended communication (often interactive) dealing with some particular topic | synonyms=discussion, discourse | examples=the book contains an excellent discussion of modal logic; his treatment of the race question is badly biased

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context is about medical treatment of diseases (malignant pleural mesothelioma, non-small cell lung cancer) using a medicine called Alimta. This is clearly about medical care provided to relieve illness.

Sense 1: "care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)" - This fits perfectly.
Sense 2: "the management of someone or something" - More about handling, like water treatment or prisoner handling.
Sense 3: "a manner of dealing with something artistically" - Not relevant.
Sense 4: "an extended communication dealing with some particular topic" - Not relevant.

The best sense is Sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cell
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small <t>cell</t> lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The target word "cell" appears in the context: "non-small cell lung cancer". This is a medical/biological context discussing pemetrexed, a medicine that kills dividing cells like cancer cells. The word "cell" here refers to the biological unit - specifically referring to the type of lung cancer characterized by the cells involved. This clearly maps to sense 2: "(biology) the basic structural and functional unit of all organisms."


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: effect
Target surface form: effects
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the <t>effects</t> of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=effect%1:19:00:: | definition=a phenomenon that follows and is caused by some previous phenomenon | synonyms=consequence, outcome, result, event, issue, upshot | examples=the magnetic effect was greater when the rod was lengthwise; his decision had depressing consequences for business
2. sense_key=effect%1:07:00:: | definition=an outward appearance | synonyms=impression | examples=he made a good impression; I wanted to create an impression of success
3. sense_key=effect%1:09:00:: | definition=an impression (especially one that is artificial or contrived) | examples=he just did it for effect
4. sense_key=effect%1:10:00:: | definition=the central meaning or theme of a speech or literary work | synonyms=essence, burden, core, gist
5. sense_key=effect%1:07:01:: | definition=(of a law) having legal validity | synonyms=force | examples=the law is still in effect
6. sense_key=effect%1:26:00:: | definition=a symptom caused by an illness or a drug | examples=the effects of sleep loss; the effect of the anesthetic

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "effects" in the context: "the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients."

This is talking about the therapeutic effects/outcomes of a medicine being compared in a clinical study. The word "effects" here refers to the results or consequences of taking the medicine - how well it works.

Looking at the candidate senses:

1. effect%1:19:00:: - "a phenomenon that follows and is caused by some previous phenomenon" - synonyms: consequence, outcome, result, event, issue, upshot
2. effect%1:07:00:: - "an outward appearance" - synonyms: impression
3. effect%1:09:00:: - "an impression (especially one that is artificial or contrived)"
4. effect%1:10:00:: - "the central meaning or theme of a speech or literary work"
5. effect%1:07:01:: - "(of a law) having legal validity"
6. effect%1:26:00:: - "a symptom caused by an illness or a drug" - examples: the effects of sleep loss; the effect of the anesthetic

Sense 1 is about consequences/outcomes/results generally, and sense 6 is specifically about symptoms caused by illness or drugs.

In the context, "the effects of Alimta were compared with those of docetaxel" - this is comparing the therapeutic effects/outcomes of two medicines. While sense 6 is about symptoms caused by drugs, the context is more about comparing the therapeutic outcomes (how well the drugs work) rather than side effects/symptoms.

However, let me reconsider. The example for sense 6 is "the effects of sleep loss; the effect of the anesthetic" - these are negative effects/symptoms. In the context of comparing two medicines, the "effects" being compared are likely the therapeutic effects or overall outcomes.

Sense 1 is more general - "a phenomenon that follows and is caused by some previous phenomenon" with synonyms like consequence, outcome, result. This fits well with comparing the effects/outcomes of two medicines.

I think sense 1 is the best fit here, as it's about the results/outcomes of a treatment, which is what's being compared in this clinical study context.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: compare
Target surface form: compared
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were <t>compared</t> with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=compare%2:31:00:: | definition=examine and note the similarities or differences of | examples=John compared his haircut to his friend's; We compared notes after we had both seen the movie
2. sense_key=compare%2:42:00:: | definition=be comparable | examples=This car does not compare with our line of Mercedes
3. sense_key=compare%2:31:01:: | definition=consider or describe as similar, equal, or analogous | synonyms=liken, equate | examples=We can compare the Han dynasty to the Romans; You cannot equate success in financial matters with greed
4. sense_key=compare%2:32:00:: | definition=to form the comparative or superlative form on an adjective or adverb

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context discusses comparing the effects of two medicines - examining their similarities and differences. "The effects of Pemetrexed were compared with those of docetaxel" - this is about examining and noting the similarities or differences of two things. This matches sense 1: "examine and note the similarities or differences of."


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer <t>medicine</t>) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word "medicine" appears in the context: "anticancer medicine". This refers to a drug/substance used to treat disease. Looking at the candidate senses:

1. medical specialty - doesn't fit
2. medication, medicament, medicinal drug - "something that treats or prevents or alleviates the symptoms of disease" - this fits perfectly as "medicine" here refers to a drug (anticancer medicine = anticancer drug)
3. practice of medicine - doesn't fit
4. punishment - doesn't fit

The answer is sense_index 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: study
Target surface form: study
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one <t>study</t> involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=study%1:04:00:: | definition=a detailed critical inspection | synonyms=survey
2. sense_key=study%1:09:03:: | definition=applying the mind to learning and understanding a subject (especially by reading) | synonyms=work | examples=mastering a second language requires a lot of work; no schools offer graduate study in interior design
3. sense_key=study%1:10:00:: | definition=a written document describing the findings of some individual or group | synonyms=report, written report | examples=this accords with the recent study by Hill and Dale
4. sense_key=study%1:09:04:: | definition=a state of deep mental absorption | examples=she is in a deep study
5. sense_key=study%1:06:00:: | definition=a room used for reading and writing and studying | examples=he knocked lightly on the closed door of the study
6. sense_key=study%1:09:02:: | definition=a branch of knowledge | synonyms=discipline, subject, subject area, subject field, field, field of study | examples=in what discipline is his doctorate?; teachers should be well trained in their subject
7. sense_key=study%1:06:01:: | definition=preliminary drawing for later elaboration | synonyms=sketch | examples=he made several studies before starting to paint
8. sense_key=study%1:09:01:: | definition=attentive consideration and meditation | synonyms=cogitation | examples=after much cogitation he rejected the offer
9. sense_key=study%1:18:00:: | definition=someone who memorizes quickly and easily (as the lines for a part in a play) | examples=he is a quick study
10. sense_key=study%1:10:01:: | definition=a composition intended to develop one aspect of the performer's technique | examples=a study in spiccato bowing

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word "study" appears in the context: "the effects of Pemetrexed were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients..."

This is referring to a clinical trial or research investigation. Let me look at the candidate senses:

1. "a detailed critical inspection" - survey - doesn't quite fit
2. "applying the mind to learning and understanding a subject" - work - doesn't fit
3. "a written document describing the findings of some individual or group" - report, written report - examples include "this accords with the recent study by Hill and Dale" - this could fit
4. "a state of deep mental absorption" - no
5. "a room used for reading and writing and studying" - no
6. "a branch of knowledge" - discipline - no
7. "preliminary drawing for later elaboration" - sketch - no
8. "attentive consideration and meditation" - cogitation - no
9. "someone who memorizes quickly and easily" - no
10. "a composition intended to develop one aspect of the performer's technique" - no

The context is talking about a clinical study (research investigation) involving patients. Sense 3 is about "a written document describing the findings" - this fits well as studies in medical contexts are typically research reports/findings.

Actually, looking more carefully, the context is about a clinical study/trial. The sense "a written document describing the findings of some individual or group" with the example "this accords with the recent study by Hill and Dale" fits well because in medical contexts, "study" often refers to a research report documenting findings from a clinical trial.

Sense 3 is the best match.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: involve
Target surface form: involving
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study <t>involving</t> 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=involve%2:42:01:: | definition=connect closely and often incriminatingly | synonyms=affect, regard | examples=This new ruling affects your business
2. sense_key=involve%2:42:04:: | definition=engage as a participant | examples=Don't involve me in your family affairs!
3. sense_key=involve%2:42:00:: | definition=have as a necessary feature | synonyms=imply | examples=This decision involves many changes
4. sense_key=involve%2:42:07:: | definition=require as useful, just, or proper | synonyms=necessitate, ask, postulate, need, require, take | examples=It takes nerve to do what she did; success usually requires hard work
5. sense_key=involve%2:42:02:: | definition=contain as a part | examples=Dinner at Joe's always involves at least six courses
6. sense_key=involve%2:31:00:: | definition=occupy or engage the interest of | examples=His story completely involved me during the entire afternoon
7. sense_key=involve%2:30:00:: | definition=make complex or intricate or complicated | examples=The situation was rather involved

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "involving" in the phrase "a study involving 571 patients."

Let me analyze the context: "the effects of Pemetrexed were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past."

Here, "involving 571 patients" means the study includes/engages 571 patients as participants. The study involves (has as participants) 571 patients.

Let me look at the candidate senses:

1. "connect closely and often incriminatingly" - synonyms: affect, regard. Example: "This new ruling affects your business." This doesn't fit well.

2. "engage as a participant" - Example: "Don't involve me in your family affairs!" This sense is about engaging someone as a participant. "A study involving 571 patients" - the study has 571 patients as participants. This fits well.

3. "have as a necessary feature" - synonyms: imply. Example: "This decision involves many changes." This is about something being a necessary feature, not about participants.

4. "require as useful, just, or proper" - synonyms: necessitate, ask, postulate, need, require, take. Doesn't fit.

5. "contain as a part" - Example: "Dinner at Joe's always involves at least six courses." This is about containing as a part, not specifically about participants.

6. "occupy or engage the interest of" - Example: "His story completely involved me during the entire afternoon." This is about engaging attention/interest, not about being a participant.

7. "make complex or intricate or complicated" - Example: "The situation was rather involved." This is about complexity.

The best fit is sense 2: "engage as a participant." The study involves 571 patients - it engages them as participants in the study.

Wait, let me reconsider. Sense 5 "contain as a part" could also work - the study contains 571 patients as a part. But sense 2 is more specific to participants, and the context is clearly about patients being participants in the study.

Actually, looking more carefully at WordNet's structure, "engage as a participant" (sense 2) is specifically about being a participant. "A study involving 571 patients" means the study engages 571 patients as participants. This is the best fit.

The sense index for this would be 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 <t>patients</t> with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output: {"sense_index": 1}{"sense_index": 1}

content: {"sense_index": 1}{"sense_index": 1}

reasoning_content:
The target word is "patients" in a medical context about Alimta (pemetrexed), a cytotoxic medicine used to treat cancer. The context clearly refers to people receiving medical treatment - "456 patients who had not received chemotherapy," "571 patients with locally advanced or metastatic disease," "1,725 patients who had not received chemotherapy for lung cancer."

This clearly matches sense 1: "a person who requires medical care" with the example "the number of emergency patients has grown rapidly."

Sense 2 is about a linguistic/semantic role, which doesn't apply here at all.

provider: AtlasCloud


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 <t>patients</t> with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

[Assistant] {"sense_index": 1}{"sense_index": 1}

[User] Your previous answer was invalid. Choose one candidate index between 1 and 2. Return only valid JSON exactly like {"sense_index": 1}.

content: {"sense_index": 1}{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: locally
Target surface form: locally
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with <t>locally</t> advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=locally%4:02:00:: | definition=by a particular locality | examples=it was locally decided
2. sense_key=locally%4:02:01:: | definition=to a restricted area of the body | synonyms=topically | examples=apply this medicine topically

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context is about a medical treatment description for Alimta (pemetrexed). The phrase "locally advanced or metastatic disease" refers to cancer that is advanced but confined to a local/regional area of the body, as opposed to having spread (metastasized) throughout the body. This is a standard medical usage of "locally" meaning "in a restricted area of the body" or "confined to a particular region."

Looking at the candidate senses:
1. sense_key=locally%4:02:00:: | definition="by a particular locality" - This is more about decisions or things being made/done by a local community or in a particular place.
2. sense_key=locally%4:02:01:: | definition="to a restricted area of the body" - This is about medicine being applied to a specific area of the body.

The second sense fits the medical context best. In "locally advanced or metastatic disease," "locally" refers to the disease being advanced but still restricted to a local area of the body, as opposed to metastatic (spread throughout the body). This aligns with sense 2's definition of "to a restricted area of the body."


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: advanced
Target surface form: advanced
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally <t>advanced</t> or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=advanced%5:00:00:precocious:00 | definition=farther along in physical or mental development | examples=the child's skeletal age was classified as `advanced'; children in the advanced classes in elementary school read far above grade average
2. sense_key=advanced%5:00:00:late:02 | definition=comparatively late in a course of development | examples=the illness had reached an advanced stage; an advanced state of exhaustion
3. sense_key=advanced%5:00:00:progressive:01 | definition=ahead of the times | synonyms=forward-looking, innovative, modern | examples=the advanced teaching methods; had advanced views on the subject
4. sense_key=advanced%5:00:02:high:02 | definition=at a higher level in training or knowledge or skill | examples=an advanced degree; an advanced text in physics
5. sense_key=advanced%5:00:00:high-tech:00 | definition=ahead in development; complex or intricate | synonyms=sophisticated | examples=advanced technology; a sophisticated electronic control system
6. sense_key=advanced%5:00:00:late:00 | definition=far along in time | synonyms=ripe | examples=a man of advanced age; advanced in years
7. sense_key=advanced%5:00:00:civilized:00 | definition=(of societies) highly developed especially in technology or industry | examples=advanced societies; an advanced country technologically
8. sense_key=advanced%5:00:00:front:00 | definition=situated ahead or going before | synonyms=advance, in advance | examples=an advance party; at that time the most advanced outpost was still east of the Rockies

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context is about cancer treatment: "locally advanced or metastatic disease." Here, "advanced" refers to a stage of disease that is far along in progression. This matches sense 2: "comparatively late in a course of development" with examples like "the illness had reached an advanced stage; an advanced state of exhaustion." This is the medical usage describing disease progression.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: past
Target surface form: past
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the <t>past</t>. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=past%1:28:00:: | definition=the time that has elapsed | synonyms=past times, yesteryear | examples=forget the past
2. sense_key=past%1:28:01:: | definition=a earlier period in someone's life (especially one that they have reason to keep secret) | examples=reporters dug into the candidate's past
3. sense_key=past%1:10:00:: | definition=a verb tense that expresses actions or states in the past | synonyms=past tense

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word "past" appears in the context: "who had received chemotherapy in the past" and "who had not received chemotherapy for lung cancer in the past."

This refers to a time period that has elapsed - specifically, prior to the current time. This matches sense 1: "the time that has elapsed" (synonyms: past times, yesteryear).

Sense 2 refers to a secret period in someone's life, which doesn't fit.
Sense 3 refers to a verb tense, which doesn't fit.

The answer is sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: compare
Target surface form: compared
Context:
In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also <t>compared</t> with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past. In all three studies, the main measure of effectiveness was how long the patients survived.

Candidate senses:
1. sense_key=compare%2:31:00:: | definition=examine and note the similarities or differences of | examples=John compared his haircut to his friend's; We compared notes after we had both seen the movie
2. sense_key=compare%2:42:00:: | definition=be comparable | examples=This car does not compare with our line of Mercedes
3. sense_key=compare%2:31:01:: | definition=consider or describe as similar, equal, or analogous | synonyms=liken, equate | examples=We can compare the Han dynasty to the Romans; You cannot equate success in financial matters with greed
4. sense_key=compare%2:32:00:: | definition=to form the comparative or superlative form on an adjective or adverb

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "compared" in the context: "Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin..."

This is about examining similarities or differences between treatments - Alimta vs gemcitabine. This matches sense 1: "examine and note the similarities or differences of" with examples like "John compared his haircut to his friend's."

Sense 3 is about likening or equating things as similar/equal/analogous, which is more about metaphorical comparison. The context here is a clinical study examining differences in effectiveness, which fits sense 1 better.

Sense 1 is the best match.