[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: polyp
Target surface form: polyps
Context:
He believed colon cancer might also arise from multiple "hits "on cancer suppressor genes, because it often seems to develop in stages. It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring. Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign <t>polyps</t> would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy.

Candidate senses:
1. sense_key=polyp%1:26:00:: | definition=a small vascular growth on the surface of a mucous membrane | synonyms=polypus
2. sense_key=polyp%1:05:00:: | definition=one of two forms that coelenterates take (e.g. a hydra or coral): usually sedentary with a hollow cylindrical body usually with a ring of tentacles around the mouth | examples=in some species of coelenterate, polyps are a phase in the life cycle that alternates with a medusoid phase

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context is about colon cancer, polyps in the bowel, and genetic damage. This refers to polyps as small vascular growths on a mucous membrane, not the coelenterate form. Sense 1 is the correct choice.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: develop
Target surface form: develop
Context:
He believed colon cancer might also arise from multiple "hits "on cancer suppressor genes, because it often seems to develop in stages. It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring. Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would <t>develop</t>. If both copies of a second gene were then deleted, the polyps would progress to malignancy.

Candidate senses:
1. sense_key=develop%2:36:01:: | definition=make something new, such as a product or a mental or artistic creation | examples=Her company developed a new kind of building material that withstands all kinds of weather; They developed a new technique
2. sense_key=develop%2:36:00:: | definition=work out | synonyms=evolve, germinate | examples=We have developed a new theory of evolution
3. sense_key=develop%2:30:06:: | definition=gain through experience | synonyms=acquire, evolve | examples=I acquired a strong aversion to television; Children must develop a sense of right and wrong
4. sense_key=develop%2:29:00:: | definition=come to have or undergo a change of (physical features and attributes) | synonyms=grow, produce, get, acquire | examples=He grew a beard; The patient developed abdominal pains
5. sense_key=develop%2:42:00:: | definition=come into existence; take on form or shape | synonyms=originate, arise, rise, uprise, spring up, grow | examples=A new religious movement originated in that country; a love that sprang up from friendship
6. sense_key=develop%2:30:04:: | definition=change the use of and make available or usable | synonyms=build up | examples=develop land; The country developed its natural resources
7. sense_key=develop%2:32:00:: | definition=elaborate, as of theories and hypotheses | synonyms=explicate, formulate | examples=Could you develop the ideas in your thesis
8. sense_key=develop%2:31:00:: | definition=create by training and teaching | synonyms=train, prepare, educate | examples=The old master is training world-class violinists; we develop the leaders for the future
9. sense_key=develop%2:30:05:: | definition=be gradually disclosed or unfolded; become manifest | examples=The plot developed slowly
10. sense_key=develop%2:30:00:: | definition=grow, progress, unfold, or evolve through a process of evolution, natural growth, differentiation, or a conducive environment | examples=A flower developed on the branch; The country developed into a mighty superpower
11. sense_key=develop%2:30:09:: | definition=become technologically advanced | synonyms=modernize, modernise | examples=Many countries in Asia are now developing at a very fast pace; Viet Nam is modernizing rapidly
12. sense_key=develop%2:30:01:: | definition=cause to grow and differentiate in ways conforming to its natural development | synonyms=make grow | examples=The perfect climate here develops the grain; He developed a new kind of apple
13. sense_key=develop%2:36:09:: | definition=generate gradually | examples=We must develop more potential customers; develop a market for the new mobile phone
14. sense_key=develop%2:30:10:: | definition=grow emotionally or mature | synonyms=grow | examples=The child developed beautifully in her new kindergarten; When he spent a summer at camp, the boy grew noticeably and no longer showed some of his old adolescent behavior
15. sense_key=develop%2:39:00:: | definition=make visible by means of chemical solutions | examples=Please develop this roll of film for me
16. sense_key=develop%2:35:04:: | definition=superimpose a three-dimensional surface on a plane without stretching, in geometry
17. sense_key=develop%2:33:03:: | definition=move one's pieces into strategically more advantageous positions | examples=Spassky developed quickly
18. sense_key=develop%2:33:02:: | definition=move into a strategically more advantageous position | examples=develop the rook
19. sense_key=develop%2:30:13:: | definition=elaborate by the unfolding of a musical idea and by the working out of the rhythmic and harmonic changes in the theme | examples=develop the melody and change the key
20. sense_key=develop%2:30:03:: | definition=happen | synonyms=break, recrudesce | examples=Report the news as it develops; These political movements recrudesce from time to time
21. sense_key=develop%2:30:12:: | definition=expand in the form of a series | examples=Develop the function in the following form

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

finish_reason: stop

role: assistant

reasoning_content:
The context is about colon cancer and how benign polyps "develop" when both copies of a certain gene are knocked out. This is about polyps coming into existence or forming, which aligns with the sense "come into existence; take on form or shape" (sense 5) or possibly "grow, progress, unfold, or evolve through a process of evolution, natural growth" (sense 10).

Looking at the sentence: "If both copies of a certain gene were knocked out, benign polyps would develop." The polyps are coming into existence as a result of genetic changes. This is about something coming into existence/forming.

Sense 5: "come into existence; take on form or shape" with synonyms like originate, arise, rise, uprise, spring up, grow. This fits well because the polyps are coming into existence.

Sense 10: "grow, progress, unfold, or evolve through a process of evolution, natural growth, differentiation, or a conducive environment" - this also fits because polyps are growing/forming.

The earlier sentence says "it often seems to develop in stages" - here develop means to progress/evolve through stages, which fits sense 10.

But in the target sentence "benign polyps would develop", the polyps are coming into existence from genetic changes. This could be either sense 5 or sense 10.

Looking at the examples for sense 5: "A new religious movement originated in that country; a love that sprang up from friendship" - these are about things coming into being.

Looking at sense 10: "A flower developed on the branch" - this is about something growing/forming on something else.

I think sense 5 is the best fit because the polyps are coming into existence as a result of the gene being knocked out. The sense is about something coming into being/originating.

Actually, re-reading: "benign polyps would develop" - this is about the formation/coming into existence of polyps due to genetic changes. Sense 5 "come into existence; take on form or shape" with synonyms originate, arise seems most appropriate.

Let me check sense 10 again: "grow, progress, unfold, or evolve through a process of evolution, natural growth, differentiation" - the polyps aren't really "growing" in the sense of getting bigger, they are forming/coming into being.

I'll go with sense 5.

format: unknown

native_finish_reason: stop

provider: Minimax

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: copy
Target surface form: copies
Context:
It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring. Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both <t>copies</t> of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop.

Candidate senses:
1. sense_key=copy%1:10:00:: | definition=a reproduction of a written record (e.g. of a legal or school record) | synonyms=transcript
2. sense_key=copy%1:06:00:: | definition=a thing made to be similar or identical to another thing | examples=she made a copy of the designer dress; the clone was a copy of its ancestor
3. sense_key=copy%1:10:01:: | definition=matter to be printed; exclusive of graphical materials | synonyms=written matter
4. sense_key=copy%1:10:02:: | definition=material suitable for a journalistic account | examples=catastrophes make good copy

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context is about genetics, specifically about genes and chromosomes. "If both copies of a certain gene were knocked out..." - here "copies" refers to the two copies (alleles) of a gene in a genome. This is the biological/genetic sense of "copy" meaning a duplicate or instance of a gene.

Looking at the candidate senses:
1. copy%1:10:00:: - a reproduction of a written record - no
2. copy%1:06:00:: - a thing made to be similar or identical to another thing - this is the closest, as genes come in pairs/copies which are similar/identical
3. copy%1:10:01:: - matter to be printed - no
4. copy%1:10:02:: - material suitable for a journalistic account - no

Sense 2 is the best match. The examples mention "the clone was a copy of its ancestor" which is similar to the genetic sense where one copy of a gene is similar to the other.

provider: Novita


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: second
Target surface form: second
Context:
It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring. Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a <t>second</t> gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop.

Candidate senses:
1. sense_key=second%5:00:00:ordinal:00 | definition=coming next after the first in position in space or time or degree or magnitude | synonyms=2nd, 2d
2. sense_key=second%3:00:00:: | definition=a part or voice or instrument or orchestra section lower in pitch than or subordinate to the first | examples=second flute; the second violins

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word "second" in the context refers to "a second gene" - meaning another gene in addition to the first one mentioned. This is the ordinal sense - coming next after the first.

Sense 1: "coming next after the first in position in space or time or degree or magnitude" - This matches perfectly, as it refers to a second gene (another one, next after the first).

Sense 2: "a part or voice or instrument or orchestra section lower in pitch than or subordinate to the first" - This is about music/orchestra, not relevant here.

The answer is sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: then
Target surface form: then
Context:
It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring. Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were <t>then</t> deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop.

Candidate senses:
1. sense_key=then%4:02:00:: | definition=subsequently or soon afterward (often used as sentence connectors) | synonyms=so, and so, and then | examples=then he left; go left first, then right
2. sense_key=then%4:02:02:: | definition=in that case or as a consequence | examples=if he didn't take it, then who did?; keep it then if you want to
3. sense_key=then%4:02:01:: | definition=at that time | examples=I was young then; prices were lower back then

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output: {"sense_index": 1}{"sense_index": 1}

content: {"sense_index": 1}{"sense_index": 1}

reasoning_content:
The target word is "then" in the context: "If both copies of a second gene were then deleted, the polyps would progress to malignancy."

Here, "then" is used to indicate a subsequent step in a sequence - first one gene is knocked out, then a second gene is deleted. This is a temporal/sequential usage meaning "subsequently" or "after that."

Sense 1: "subsequently or soon afterward" - This matches the sequential usage.
Sense 2: "in that case or as a consequence" - This is more conditional/consequential.
Sense 3: "at that time" - This refers to a specific point in time.

The best fit is Sense 1, as it indicates the sequential progression in the cascade of genetic damage described in the context.

provider: AtlasCloud


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: then
Target surface form: then
Context:
It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring. Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were <t>then</t> deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop.

Candidate senses:
1. sense_key=then%4:02:00:: | definition=subsequently or soon afterward (often used as sentence connectors) | synonyms=so, and so, and then | examples=then he left; go left first, then right
2. sense_key=then%4:02:02:: | definition=in that case or as a consequence | examples=if he didn't take it, then who did?; keep it then if you want to
3. sense_key=then%4:02:01:: | definition=at that time | examples=I was young then; prices were lower back then

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

[Assistant] {"sense_index": 1}{"sense_index": 1}

[User] Your previous answer was invalid. Choose one candidate index between 1 and 3. Return only valid JSON exactly like {"sense_index": 1}.

content: {"sense_index": 1}{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: delete
Target surface form: deleted
Context:
It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring. Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then <t>deleted</t>, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop.

Candidate senses:
1. sense_key=delete%2:35:00:: | definition=remove or make invisible | synonyms=cancel | examples=Please delete my name from your list
2. sense_key=delete%2:32:00:: | definition=wipe out digitally or magnetically recorded information | synonyms=erase | examples=Who erased the files form my hard disk?
3. sense_key=delete%2:30:00:: | definition=cut or eliminate | synonyms=edit, blue-pencil | examples=she edited the juiciest scenes

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context is about genetic deletions - genes being "deleted" from chromosomes. This refers to the removal/elimination of genetic material. Let me look at the candidate senses:

1. "remove or make invisible" - synonyms: cancel
2. "wipe out digitally or magnetically recorded information" - synonyms: erase
3. "cut or eliminate" - synonyms: edit, blue-pencil

The context is about genes being "knocked out" and "deleted" - this is about cutting or eliminating genetic material. Sense 3 "cut or eliminate" with synonyms "edit, blue-pencil" seems closest to the biological meaning of genetic deletion, where segments of DNA are removed/eliminated.

Sense 1 is more about removing entries from lists or making things invisible.
Sense 2 is specifically about digital/magnetic recording.
Sense 3 is about cutting or eliminating, which fits the biological context of genetic deletion.

The answer is sense 3.

provider: Parasail


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: polyp
Target surface form: polyps
Context:
It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring. Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the <t>polyps</t> would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop.

Candidate senses:
1. sense_key=polyp%1:26:00:: | definition=a small vascular growth on the surface of a mucous membrane | synonyms=polypus
2. sense_key=polyp%1:05:00:: | definition=one of two forms that coelenterates take (e.g. a hydra or coral): usually sedentary with a hollow cylindrical body usually with a ring of tentacles around the mouth | examples=in some species of coelenterate, polyps are a phase in the life cycle that alternates with a medusoid phase

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context is about polyps in the bowel, which are small growths on the mucous membrane of the colon. This matches sense 1, which describes "a small vascular growth on the surface of a mucous membrane." Sense 2 refers to coelenterate polyps (like coral or hydra), which is not relevant here.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: malignancy
Target surface form: malignancy
Context:
It often is preceded by the development of polyps in the bowel, which in some cases become increasingly malignant in identifiable stages -- progressing from less severe to deadly -- as though a cascade of genetic damage might be occurring. Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to <t>malignancy</t>. It was clear that more than one gene had to be damaged for colon cancer to develop.

Candidate senses:
1. sense_key=malignancy%1:26:00:: | definition=(medicine) a malignant state; progressive and resistant to treatment and tending to cause death | synonyms=malignance
2. sense_key=malignancy%1:07:00:: | definition=quality of being disposed to evil; intense ill will | synonyms=malignity, malignance

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context is about medical/cancer development - colon cancer, polyps, genetic damage, malignant cells. The word "malignancy" here refers to the medical condition of cancer. This is clearly sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: clear
Target surface form: clear
Context:
Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was <t>clear</t> that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists.

Candidate senses:
1. sense_key=clear%3:00:00:: | definition=readily apparent to the mind | examples=a clear and present danger; a clear explanation
2. sense_key=clear%5:00:00:clearheaded:00 | definition=free from confusion or doubt | examples=a complex problem requiring a clear head; not clear about what is expected of us
3. sense_key=clear%5:00:00:unobstructed:00 | definition=affording free passage or view | synonyms=open | examples=a clear view; a clear path to victory
4. sense_key=clear%3:00:02:: | definition=allowing light to pass through | examples=clear water; clear plastic bags
5. sense_key=clear%5:00:02:free:00 | definition=free from contact or proximity or connection | examples=we were clear of the danger; the ship was clear of the reef
6. sense_key=clear%5:00:00:untroubled:00 | definition=characterized by freedom from troubling thoughts (especially guilt) | examples=a clear conscience; regarded her questioner with clear untroubled eyes
7. sense_key=clear%5:00:01:pure:02 | definition=(of sound or color) free from anything that dulls or dims | synonyms=clean, light, unclouded | examples=efforts to obtain a clean bass in orchestral recordings; clear laughter like a waterfall
8. sense_key=clear%5:00:00:unencumbered:00 | definition=(especially of a title) free from any encumbrance or limitation that presents a question of fact or law | synonyms=unmortgaged | examples=I have clear title to this property
9. sense_key=clear%5:00:00:distinct:00 | definition=clear and distinct to the senses; easily perceptible | synonyms=clean-cut, clear-cut | examples=as clear as a whistle; clear footprints in the snow
10. sense_key=clear%3:00:04:: | definition=accurately stated or described | synonyms=well-defined | examples=a set of well-defined values
11. sense_key=clear%3:00:03:: | definition=free from clouds or mist or haze | examples=on a clear day
12. sense_key=clear%5:00:00:unqualified:02 | definition=free of restrictions or qualifications | synonyms=clean | examples=a clean bill of health; a clear winner
13. sense_key=clear%5:00:00:perfect:00 | definition=free from flaw or blemish or impurity | examples=a clear perfect diamond; the clear complexion of a healthy young woman
14. sense_key=clear%5:00:00:net:00 | definition=clear of charges or deductions | examples=a clear profit
15. sense_key=clear%5:00:00:legible:00 | definition=easily deciphered | synonyms=decipherable, readable
16. sense_key=clear%5:00:00:innocent:00 | definition=freed from any question of guilt | synonyms=absolved, cleared, exculpated, exonerated, vindicated | examples=is absolved from all blame; was now clear of the charge of cowardice
17. sense_key=clear%5:00:00:discerning:00 | definition=characterized by ease and quickness in perceiving | synonyms=percipient | examples=clear mind; a percipient author

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content: {"sense_index": 1}{"sense_index": 1}

reasoning_content:
The sentence is: "It was clear that more than one gene had to be damaged for colon cancer to develop."

In this context, "clear" means "readily apparent to the mind" or "obvious/evident." The speaker is saying that it was obvious/evident that more than one gene had to be damaged.

Looking at the candidate senses:

1. sense_key=clear%3:00:00:: | definition=readily apparent to the mind | examples=a clear and present danger; a clear explanation

This fits perfectly. "It was clear that..." means "It was readily apparent/evident that..." which matches sense 1.

Sense 2 is about being "free from confusion or doubt" - this could also be relevant, but sense 1 is more directly about something being apparent/evident to the mind, which is what "it was clear that X" typically means.

The phrase "It was clear that..." is a standard way of saying "It was obvious/evident that..." - this is sense 1, the adjective sense meaning "readily apparent to the mind."

I'll go with sense_index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: clear
Target surface form: clear
Context:
Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was <t>clear</t> that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists.

Candidate senses:
1. sense_key=clear%3:00:00:: | definition=readily apparent to the mind | examples=a clear and present danger; a clear explanation
2. sense_key=clear%5:00:00:clearheaded:00 | definition=free from confusion or doubt | examples=a complex problem requiring a clear head; not clear about what is expected of us
3. sense_key=clear%5:00:00:unobstructed:00 | definition=affording free passage or view | synonyms=open | examples=a clear view; a clear path to victory
4. sense_key=clear%3:00:02:: | definition=allowing light to pass through | examples=clear water; clear plastic bags
5. sense_key=clear%5:00:02:free:00 | definition=free from contact or proximity or connection | examples=we were clear of the danger; the ship was clear of the reef
6. sense_key=clear%5:00:00:untroubled:00 | definition=characterized by freedom from troubling thoughts (especially guilt) | examples=a clear conscience; regarded her questioner with clear untroubled eyes
7. sense_key=clear%5:00:01:pure:02 | definition=(of sound or color) free from anything that dulls or dims | synonyms=clean, light, unclouded | examples=efforts to obtain a clean bass in orchestral recordings; clear laughter like a waterfall
8. sense_key=clear%5:00:00:unencumbered:00 | definition=(especially of a title) free from any encumbrance or limitation that presents a question of fact or law | synonyms=unmortgaged | examples=I have clear title to this property
9. sense_key=clear%5:00:00:distinct:00 | definition=clear and distinct to the senses; easily perceptible | synonyms=clean-cut, clear-cut | examples=as clear as a whistle; clear footprints in the snow
10. sense_key=clear%3:00:04:: | definition=accurately stated or described | synonyms=well-defined | examples=a set of well-defined values
11. sense_key=clear%3:00:03:: | definition=free from clouds or mist or haze | examples=on a clear day
12. sense_key=clear%5:00:00:unqualified:02 | definition=free of restrictions or qualifications | synonyms=clean | examples=a clean bill of health; a clear winner
13. sense_key=clear%5:00:00:perfect:00 | definition=free from flaw or blemish or impurity | examples=a clear perfect diamond; the clear complexion of a healthy young woman
14. sense_key=clear%5:00:00:net:00 | definition=clear of charges or deductions | examples=a clear profit
15. sense_key=clear%5:00:00:legible:00 | definition=easily deciphered | synonyms=decipherable, readable
16. sense_key=clear%5:00:00:innocent:00 | definition=freed from any question of guilt | synonyms=absolved, cleared, exculpated, exonerated, vindicated | examples=is absolved from all blame; was now clear of the charge of cowardice
17. sense_key=clear%5:00:00:discerning:00 | definition=characterized by ease and quickness in perceiving | synonyms=percipient | examples=clear mind; a percipient author

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

[Assistant] {"sense_index": 1}{"sense_index": 1}

[User] Your previous answer was invalid. Choose one candidate index between 1 and 17. Return only valid JSON exactly like {"sense_index": 1}.

content: {"sense_index": 1}{"sense_index": 1}

reasoning_content:
The user wants me to choose the best sense for "clear" in the context: "It was clear that more than one gene had to be damaged for colon cancer to develop."

This means "it was evident/obvious" - something readily apparent to the mind.

Sense 1: "readily apparent to the mind" with examples "a clear and present danger; a clear explanation" - this fits well.

Sense 2: "free from confusion or doubt" - this could also fit, like "a clear understanding," but the context is more about something being evident/apparent rather than about someone being free from confusion.

The best fit is sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: damage
Target surface form: damaged
Context:
Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be <t>damaged</t> for colon cancer to develop. Their report galvanized other molecular biologists.

Candidate senses:
1. sense_key=damage%2:30:00:: | definition=inflict damage upon | examples=The snow damaged the roof; She damaged the car when she hit the tree
2. sense_key=damage%2:30:01:: | definition=suffer or be susceptible to damage | examples=These fine china cups damage easily

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context is about genes being "damaged" for colon cancer to develop. This means the genes suffered damage or were harmed. Let me look at the two candidate senses:

1. sense_key=damage%2:30:00:: | definition=inflict damage upon
2. sense_key=damage%2:30:01:: | definition=suffer or be susceptible to damage

The sentence says "more than one gene had to be damaged for colon cancer to develop." This means the genes themselves underwent damage - they suffered harm. While one could argue this is passive voice of "inflict damage upon," the more natural interpretation in WordNet terms for "damaged" as a past participle describing a state (genes that are damaged) aligns more with the concept of having suffered damage.

Actually, let me think more carefully. "Inflict damage upon" is the active transitive verb. "Suffer or be susceptible to damage" is the intransitive sense.

In the sentence "genes had to be damaged" - this is describing a state where the genes have suffered damage. The passive construction here implies the genes experienced the damage.

Sense 1 (inflict damage upon) - this is the transitive sense. In passive voice, "the genes were damaged" would correspond to this sense - someone/something inflicted damage on the genes.

Sense 2 (suffer or be susceptible to damage) - this is the intransitive sense, as in "the china cups damage easily."

In passive constructions like "genes had to be damaged," the underlying sense is typically the transitive one (sense 1) - damage was inflicted on the genes. The genes are the patient/recipient of the damaging action.

The examples for sense 1 include "The snow damaged the roof" which is similar - an external agent causing damage. Here, some process (mutations, deletions) is inflicting damage on the genes.

For sense 2, the example "These fine china cups damage easily" describes the inherent susceptibility of the objects to being damaged, not an actual instance of damage occurring.

So the better fit for "genes had to be damaged" is sense 1 - damage was inflicted upon the genes (passive voice of the transitive verb).

Wait, but I need to reconsider. The sentence says "It was clear that more than one gene had to be damaged for colon cancer to develop." This is about genes being in a damaged state. The focus is on the result - the genes are damaged (have suffered damage).

Hmm, but in WordNet's classification, when we say "the roof was damaged" vs "the roof damages easily" - the first is passive of sense 1, and the second is sense 2.

"More than one gene had to be damaged" - this is the passive of inflicting damage. So sense 1 fits better.

Actually, I want to reconsider once more. The sense distinction here is:
- Sense 1: transitive - to inflict damage (active: "X damaged Y"; passive: "Y was damaged")
- Sense 2: intransitive - to suffer damage or be susceptible to damage (no external agent)

In "genes had to be damaged," there's an implied agent (the mutations, the deletions) that is causing the damage. This is the passive of sense 1.

So sense 1 (sense_index=1) is the better choice.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: develop
Target surface form: develop
Context:
Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to <t>develop</t>. Their report galvanized other molecular biologists.

Candidate senses:
1. sense_key=develop%2:36:01:: | definition=make something new, such as a product or a mental or artistic creation | examples=Her company developed a new kind of building material that withstands all kinds of weather; They developed a new technique
2. sense_key=develop%2:36:00:: | definition=work out | synonyms=evolve, germinate | examples=We have developed a new theory of evolution
3. sense_key=develop%2:30:06:: | definition=gain through experience | synonyms=acquire, evolve | examples=I acquired a strong aversion to television; Children must develop a sense of right and wrong
4. sense_key=develop%2:29:00:: | definition=come to have or undergo a change of (physical features and attributes) | synonyms=grow, produce, get, acquire | examples=He grew a beard; The patient developed abdominal pains
5. sense_key=develop%2:42:00:: | definition=come into existence; take on form or shape | synonyms=originate, arise, rise, uprise, spring up, grow | examples=A new religious movement originated in that country; a love that sprang up from friendship
6. sense_key=develop%2:30:04:: | definition=change the use of and make available or usable | synonyms=build up | examples=develop land; The country developed its natural resources
7. sense_key=develop%2:32:00:: | definition=elaborate, as of theories and hypotheses | synonyms=explicate, formulate | examples=Could you develop the ideas in your thesis
8. sense_key=develop%2:31:00:: | definition=create by training and teaching | synonyms=train, prepare, educate | examples=The old master is training world-class violinists; we develop the leaders for the future
9. sense_key=develop%2:30:05:: | definition=be gradually disclosed or unfolded; become manifest | examples=The plot developed slowly
10. sense_key=develop%2:30:00:: | definition=grow, progress, unfold, or evolve through a process of evolution, natural growth, differentiation, or a conducive environment | examples=A flower developed on the branch; The country developed into a mighty superpower
11. sense_key=develop%2:30:09:: | definition=become technologically advanced | synonyms=modernize, modernise | examples=Many countries in Asia are now developing at a very fast pace; Viet Nam is modernizing rapidly
12. sense_key=develop%2:30:01:: | definition=cause to grow and differentiate in ways conforming to its natural development | synonyms=make grow | examples=The perfect climate here develops the grain; He developed a new kind of apple
13. sense_key=develop%2:36:09:: | definition=generate gradually | examples=We must develop more potential customers; develop a market for the new mobile phone
14. sense_key=develop%2:30:10:: | definition=grow emotionally or mature | synonyms=grow | examples=The child developed beautifully in her new kindergarten; When he spent a summer at camp, the boy grew noticeably and no longer showed some of his old adolescent behavior
15. sense_key=develop%2:39:00:: | definition=make visible by means of chemical solutions | examples=Please develop this roll of film for me
16. sense_key=develop%2:35:04:: | definition=superimpose a three-dimensional surface on a plane without stretching, in geometry
17. sense_key=develop%2:33:03:: | definition=move one's pieces into strategically more advantageous positions | examples=Spassky developed quickly
18. sense_key=develop%2:33:02:: | definition=move into a strategically more advantageous position | examples=develop the rook
19. sense_key=develop%2:30:13:: | definition=elaborate by the unfolding of a musical idea and by the working out of the rhythmic and harmonic changes in the theme | examples=develop the melody and change the key
20. sense_key=develop%2:30:03:: | definition=happen | synonyms=break, recrudesce | examples=Report the news as it develops; These political movements recrudesce from time to time
21. sense_key=develop%2:30:12:: | definition=expand in the form of a series | examples=Develop the function in the following form

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output: {"sense_index": 5}{"sense_index": 5}

content: {"sense_index": 5}{"sense_index": 5}

reasoning_content:
The context is about cancer development - specifically, "it was clear that more than one gene had to be damaged for colon cancer to develop." This means cancer comes into existence or occurs. Let me look at the candidate senses.

Sense 5: "come into existence; take on form or shape" with examples like "A new religious movement originated in that country." This fits - colon cancer comes into existence/comes about.

Sense 4: "come to have or undergo a change of (physical features and attributes)" - examples include "The patient developed abdominal pains" - this is about developing symptoms/conditions, which could also fit since the patient (the person) develops cancer.

Sense 20: "happen" with examples "Report the news as it develops" - this is close but more general.

Let me think more carefully. "For colon cancer to develop" - here "develop" is being used intransitively (no object), meaning the cancer itself comes into existence/arises. This is similar to "symptoms develop" or "a disease develops."

Sense 4: "come to have or undergo a change of (physical features and attributes)" - synonyms: grow, produce, get, acquire. The example "The patient developed abdominal pains" shows this sense where someone undergoes/develops a condition.

Sense 5: "come into existence; take on form or shape" - synonyms: originate, arise, rise, uprise, spring up, grow. Examples: "A new religious movement originated in that country."

Both could work. The question is whether the subject (colon cancer) is coming into existence (sense 5) or whether something (a person) is undergoing a change to develop cancer (sense 4).

"For colon cancer to develop" - the subject is "colon cancer" itself, and it comes into existence. This aligns more with sense 5 - "come into existence; take on form or shape."

However, sense 4 is also commonly used this way: "She developed cancer." But here the subject is "colon cancer" not a person.

Actually, in the example "The patient developed abdominal pains," the subject is the patient (a person) who undergoes the change. In "for colon cancer to develop," the subject is the cancer itself coming into being. This more naturally maps to sense 5.

I'll go with sense 5.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: develop
Target surface form: develop
Context:
Dr. Vogelstein and a doctoral student, Eric Fearon, began months of tedious and often frustrating probing of the chromosomes searching for signs of genetic damage. They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to <t>develop</t>. Their report galvanized other molecular biologists.

Candidate senses:
1. sense_key=develop%2:36:01:: | definition=make something new, such as a product or a mental or artistic creation | examples=Her company developed a new kind of building material that withstands all kinds of weather; They developed a new technique
2. sense_key=develop%2:36:00:: | definition=work out | synonyms=evolve, germinate | examples=We have developed a new theory of evolution
3. sense_key=develop%2:30:06:: | definition=gain through experience | synonyms=acquire, evolve | examples=I acquired a strong aversion to television; Children must develop a sense of right and wrong
4. sense_key=develop%2:29:00:: | definition=come to have or undergo a change of (physical features and attributes) | synonyms=grow, produce, get, acquire | examples=He grew a beard; The patient developed abdominal pains
5. sense_key=develop%2:42:00:: | definition=come into existence; take on form or shape | synonyms=originate, arise, rise, uprise, spring up, grow | examples=A new religious movement originated in that country; a love that sprang up from friendship
6. sense_key=develop%2:30:04:: | definition=change the use of and make available or usable | synonyms=build up | examples=develop land; The country developed its natural resources
7. sense_key=develop%2:32:00:: | definition=elaborate, as of theories and hypotheses | synonyms=explicate, formulate | examples=Could you develop the ideas in your thesis
8. sense_key=develop%2:31:00:: | definition=create by training and teaching | synonyms=train, prepare, educate | examples=The old master is training world-class violinists; we develop the leaders for the future
9. sense_key=develop%2:30:05:: | definition=be gradually disclosed or unfolded; become manifest | examples=The plot developed slowly
10. sense_key=develop%2:30:00:: | definition=grow, progress, unfold, or evolve through a process of evolution, natural growth, differentiation, or a conducive environment | examples=A flower developed on the branch; The country developed into a mighty superpower
11. sense_key=develop%2:30:09:: | definition=become technologically advanced | synonyms=modernize, modernise | examples=Many countries in Asia are now developing at a very fast pace; Viet Nam is modernizing rapidly
12. sense_key=develop%2:30:01:: | definition=cause to grow and differentiate in ways conforming to its natural development | synonyms=make grow | examples=The perfect climate here develops the grain; He developed a new kind of apple
13. sense_key=develop%2:36:09:: | definition=generate gradually | examples=We must develop more potential customers; develop a market for the new mobile phone
14. sense_key=develop%2:30:10:: | definition=grow emotionally or mature | synonyms=grow | examples=The child developed beautifully in her new kindergarten; When he spent a summer at camp, the boy grew noticeably and no longer showed some of his old adolescent behavior
15. sense_key=develop%2:39:00:: | definition=make visible by means of chemical solutions | examples=Please develop this roll of film for me
16. sense_key=develop%2:35:04:: | definition=superimpose a three-dimensional surface on a plane without stretching, in geometry
17. sense_key=develop%2:33:03:: | definition=move one's pieces into strategically more advantageous positions | examples=Spassky developed quickly
18. sense_key=develop%2:33:02:: | definition=move into a strategically more advantageous position | examples=develop the rook
19. sense_key=develop%2:30:13:: | definition=elaborate by the unfolding of a musical idea and by the working out of the rhythmic and harmonic changes in the theme | examples=develop the melody and change the key
20. sense_key=develop%2:30:03:: | definition=happen | synonyms=break, recrudesce | examples=Report the news as it develops; These political movements recrudesce from time to time
21. sense_key=develop%2:30:12:: | definition=expand in the form of a series | examples=Develop the function in the following form

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

[Assistant] {"sense_index": 5}{"sense_index": 5}

[User] Your previous answer was invalid. Choose one candidate index between 1 and 21. Return only valid JSON exactly like {"sense_index": 1}.

content: {"sense_index": 5}{"sense_index": 5}

reasoning_content:
The context is about colon cancer developing - meaning the cancer comes into existence/takes on form. This matches sense 5: "come into existence; take on form or shape" with synonyms like originate, arise, grow.

But let me also consider sense 4: "come to have or undergo a change of physical features and attributes" with example "The patient developed abdominal pains" - this is about a person/patient developing a condition.

And sense 10: "grow, progress, unfold, or evolve through a process of evolution, natural growth, differentiation, or a conducive environment" - this could fit cancer development too.

And sense 20: "happen" with example "Report the news as it develops" - this is more about events happening.

In the context: "more than one gene had to be damaged for colon cancer to develop" - this means for cancer to come into existence. Sense 5 is about coming into existence/taking form, which fits well. Sense 4 is about undergoing a change (like a patient developing symptoms). Sense 10 is about growing/evolving.

I think sense 4 could also work because the example "The patient developed abdominal pains" is very similar - a condition developing. But the subject here is "colon cancer" developing, which is more about coming into existence.

Actually, looking more carefully:
- Sense 4: "come to have or undergo a change of (physical features and attributes)" - this is typically used for subjects that undergo change
- Sense 5: "come into existence; take on form or shape" - this is for things that start to exist
- Sense 10: "grow, progress, unfold, or evolve through a process of evolution" - gradual growth/evolution

For "colon cancer to develop" - the cancer is coming into existence. Sense 5 fits best with "come into existence."

But the example for sense 4 "The patient developed abdominal pains" is quite similar in structure to "colon cancer to develop." Hmm.

Actually, the key difference: in sense 4, a person develops something (a condition). In sense 5, something comes into being. Here, colon cancer develops - it's the disease itself that is coming into existence, undergoing a process of formation.

I think sense 4 is the best fit because the disease is undergoing a change/progression - it develops over time through genetic damage. The example "The patient developed abdominal pains" parallels "colon cancer to develop" closely.

Wait, but sense 5's example "A new religious movement originated in that country" is about something coming into existence, which is similar to cancer coming into existence.

Let me re-read: "If both copies of a certain gene were knocked out, benign polyps would develop." - polyps develop, meaning they come into existence. Sense 5.

"It was clear that more than one gene had to be damaged for colon cancer to develop." - cancer develops, comes into existence. Sense 5.

I'll go with sense 5.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: report
Target surface form: report
Context:
They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their <t>report</t> galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City.

Candidate senses:
1. sense_key=report%1:10:03:: | definition=a written document describing the findings of some individual or group | synonyms=study, written report | examples=this accords with the recent study by Hill and Dale
2. sense_key=report%1:10:01:: | definition=the act of informing by verbal report | synonyms=account | examples=he heard reports that they were causing trouble; by all accounts they were a happy couple
3. sense_key=report%1:10:00:: | definition=a short account of the news | synonyms=news report, story, account, write up | examples=the report of his speech; the story was on the 11 o'clock news
4. sense_key=report%1:11:00:: | definition=a sharp explosive sound (especially the sound of a gun firing) | examples=they heard a violent report followed by silence
5. sense_key=report%1:10:04:: | definition=a written evaluation of a student's scholarship and deportment | synonyms=report card | examples=his father signed his report card
6. sense_key=report%1:10:02:: | definition=an essay (especially one written as an assignment) | synonyms=composition, paper, theme | examples=he got an A on his composition
7. sense_key=report%1:09:00:: | definition=the general estimation that the public has for a person | synonyms=reputation | examples=he acquired a reputation as an actor before he started writing; he was a person of bad report

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: galvanize
Target surface form: galvanized
Context:
They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report <t>galvanized</t> other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City.

Candidate senses:
1. sense_key=galvanize%2:37:00:: | definition=to stimulate to action | synonyms=startle, galvanise | examples=..startled him awake; galvanized into action
2. sense_key=galvanize%2:35:00:: | definition=cover with zinc | synonyms=galvanise | examples=galvanize steel
3. sense_key=galvanize%2:29:02:: | definition=stimulate (muscles) by administering a shock | synonyms=galvanise

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context describes a report that "galvanized other molecular biologists" - meaning it stimulated/motivated them to action. The quote "It was the confirming evidence we all needed..." supports this interpretation. This matches sense 1: "to stimulate to action."


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: other
Target surface form: other
Context:
They began uncovering a confusing variety of genetic deletions, some existing only in benign polyps, others in malignant cells and many in both polyps and malignant cells. Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized <t>other</t> molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City.

Candidate senses:
1. sense_key=other%3:00:00:: | definition=not the same one or ones already mentioned or implied; - the White Queen | examples=today isn't any other day; the construction of highways and other public works
2. sense_key=other%5:00:00:past:00 | definition=recently past | examples=the other evening
3. sense_key=other%5:00:02:past:00 | definition=belonging to the distant past | synonyms=early, former | examples=the early inhabitants of Europe; former generations
4. sense_key=other%5:00:00:strange:00 | definition=very unusual; different in character or quality from the normal or expected; - Lance Morrow | examples=a strange, other dimension...where his powers seemed to fail

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The target word "other" in the context "Their report galvanized other molecular biologists." means "other" as in additional/different ones, not the same ones already mentioned. This matches sense 1: "not the same one or ones already mentioned or implied."


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: confirming
Target surface form: confirming
Context:
Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the <t>confirming</t> evidence we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy.

Candidate senses:
1. sense_key=confirming%3:00:02:: | definition=indicating existence or presence of a suspected condition or pathogen | synonyms=positive | examples=a positive pregnancy test
2. sense_key=confirming%5:00:00:supportive:00 | definition=serving to support or corroborate | synonyms=collateral, confirmative, confirmatory, corroborative, corroboratory, substantiating | examples=collateral evidence

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word "confirming" appears in the context: "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor."

Here, "confirming" modifies "evidence" and means evidence that supports or corroborates a hypothesis. The context discusses how the report provided supporting evidence for the idea that gene losses were critical to tumor development.

Sense 1 is about indicating existence/presence (like a positive test result) - doesn't fit.
Sense 2 is about serving to support or corroborate - this fits perfectly. The "confirming evidence" is evidence that corroborates the hypothesis.

The answer is sense 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: evidence
Target surface form: evidence
Context:
Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming <t>evidence</t> we all needed that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy.

Candidate senses:
1. sense_key=evidence%1:09:00:: | definition=your basis for belief or disbelief; knowledge on which to base belief | synonyms=grounds | examples=the evidence that smoking causes lung cancer is very compelling
2. sense_key=evidence%1:10:01:: | definition=an indication that makes something evident | examples=his trembling was evidence of his fear
3. sense_key=evidence%1:10:00:: | definition=(law) all the means by which any alleged matter of fact whose truth is investigated at judicial trial is established or disproved

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word "evidence" appears in the context: "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor."

Let me analyze this. The context is about scientific research on cancer development. The "evidence" here refers to information/data/findings that support the belief that gene losses were critical to cancer development. This is about knowledge on which to base belief.

Sense 1: "your basis for belief or disbelief; knowledge on which to base belief" with example "the evidence that smoking causes lung cancer is very compelling" - This fits well. The confirming evidence is the basis for the scientists' belief that gene losses are critical.

Sense 2: "an indication that makes something evident" - This is more about a sign or indication, like "his trembling was evidence of his fear." This doesn't fit as well because the context is about scientific findings serving as confirmation, not about an indication making something evident.

Sense 3: "(law) all the means by which any alleged matter of fact whose truth is investigated at judicial trial is established or disproved" - This is specifically about legal/judicial context, which doesn't apply here.

The best fit is Sense 1, as the context describes scientific evidence that serves as a basis for belief about cancer development.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: need
Target surface form: needed
Context:
Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all <t>needed</t> that gene losses were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy.

Candidate senses:
1. sense_key=need%2:42:00:: | definition=require as useful, just, or proper | synonyms=necessitate, ask, postulate, require, take, involve | examples=It takes nerve to do what she did; success usually requires hard work
2. sense_key=need%2:34:00:: | definition=have need of | synonyms=want, require | examples=This piano wants the attention of a competent tuner
3. sense_key=need%2:34:01:: | definition=have or feel a need for | examples=always needing friends and money

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "needed" in the context: "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor."

Let me analyze the context. "It was the confirming evidence we all needed that gene losses were critical..."

Here, "needed" is used as a past tense verb meaning "required" or "had need of." The sentence structure is: "It was the confirming evidence we all needed" — meaning the evidence was something they all required/had need of.

Let me look at the candidate senses:

1. sense_key=need%2:42:00:: | definition=require as useful, just, or proper | synonyms=necessitate, ask, postulate, require, take, involve | examples=It takes nerve to do what she did; success usually requires hard work
   - This sense seems to be about something necessitating or requiring something else (often used impersonally or with things as subjects).

2. sense_key=need%2:34:00:: | definition=have need of | synonyms=want, require | examples=This piano wants the attention of a competent tuner
   - This sense is about having need of something — a personal need.

3. sense_key=need%2:34:01:: | definition=have or feel a need for | examples=always needing friends and money
   - This sense is about feeling a need for something.

The context is "the confirming evidence we all needed" — "we all" is the subject needing the evidence. This is about people having a need for something, which aligns with sense 2 (have need of) or sense 3 (have or feel a need for).

Sense 2 has definition "have need of" and synonyms "want, require" — this fits "we all needed the confirming evidence" = "we all had need of the confirming evidence."

Sense 3 has definition "have or feel a need for" with example "always needing friends and money" — this is more about an ongoing emotional or personal need.

The context is about researchers who needed confirming evidence for their hypothesis. This is more of a requirement than an emotional need. Sense 2 seems more appropriate because it's about having need of something (as a requirement), while sense 3 is about feeling a need (more emotional/personal).

Actually, let me reconsider. The distinction between sense 2 and sense 3 is subtle. Sense 2 is "have need of" and sense 3 is "have or feel a need for."

In "we all needed the confirming evidence" — this is about the researchers requiring/being in need of evidence. The word "needed" here means "required" or "lacked."

Sense 2 with "have need of" and synonyms "want, require" seems to fit best. The example "This piano wants the attention of a competent tuner" shows a similar structure of something needing something.

Wait, but in the sentence, "we" is the one needing the evidence, not the evidence needing something. Let me think about this more carefully.

"We all needed" — the subject is "we" and they needed the evidence. This is people requiring/having need of something.

Sense 1 is more about things that necessitate or require — often with impersonal subjects or when something makes something else necessary.

Between senses 2 and 3: sense 2 is "have need of" (synonyms: want, require), and sense 3 is "have or feel a need for" (example: always needing friends and money).

The context is about scientific evidence that was required for a conclusion. This is more about a requirement/necessity than an emotional feeling. Sense 2 with "require" as a synonym seems most appropriate.

So I'll go with sense 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: loss
Target surface form: losses
Context:
Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene <t>losses</t> were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy.

Candidate senses:
1. sense_key=loss%1:21:01:: | definition=something that is lost | examples=the car was a total loss; loss of livestock left the rancher bankrupt
2. sense_key=loss%1:22:00:: | definition=gradual decline in amount or activity | examples=weight loss; a serious loss of business
3. sense_key=loss%1:04:00:: | definition=the act of losing someone or something | examples=everyone expected him to win so his loss was a shock
4. sense_key=loss%1:07:00:: | definition=the disadvantage that results from losing something | synonyms=deprivation | examples=his loss of credibility led to his resignation; losing him is no great deprivation
5. sense_key=loss%1:11:01:: | definition=the experience of losing a loved one | examples=he sympathized on the loss of their grandfather
6. sense_key=loss%1:21:00:: | definition=the amount by which the cost of a business exceeds its revenue | synonyms=red ink, red | examples=the company operated at a loss last year; the company operated in the red last year
7. sense_key=loss%1:11:00:: | definition=military personnel lost by death or capture | synonyms=personnel casualty
8. sense_key=loss%1:11:02:: | definition=euphemistic expressions for death | synonyms=passing, departure, exit, expiration, going, release | examples=thousands mourned his passing

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content: {"sense_index": 1}{"sense_index": 1}

reasoning_content:
The target word is "losses" in the context of "gene losses" being critical to the development of cancer. This refers to the loss of genes (i.e., genes being lost or damaged/deleted). The context talks about genes being "knocked out" and "deleted," so "gene losses" means the loss/deletion of genes.

Let me look at the candidate senses:

1. sense_key=loss%1:21:01:: | definition=something that is lost | examples=the car was a total loss; loss of livestock left the rancher bankrupt
2. sense_key=loss%1:22:00:: | definition=gradual decline in amount or activity | examples=weight loss; a serious loss of business
3. sense_key=loss%1:04:00:: | definition=the act of losing someone or something
4. sense_key=loss%1:07:00:: | definition=the disadvantage that results from losing something | synonyms=deprivation
5. sense_key=loss%1:11:01:: | definition=the experience of losing a loved one
6. sense_key=loss%1:21:00:: | definition=the amount by which the cost of a business exceeds its revenue
7. sense_key=loss%1:11:00:: | definition=military personnel lost by death or capture
8. sense_key=loss%1:11:02:: | definition=euphemistic expressions for death

"Gene losses" here refers to genes that are lost (deleted/knocked out). This is about the act of losing genes, or the genes that are lost.

Sense 1: "something that is lost" - this could fit. Gene losses = things (genes) that are lost.
Sense 3: "the act of losing someone or something" - this could also fit, as gene losses could mean the act of losing genes.
Sense 4: "the disadvantage that results from losing something" - doesn't quite fit the context.

Looking at the context more carefully: "gene losses were critical to the development of a common tumor" - this means the losing of genes was critical. The genes themselves are what's lost.

In scientific/genetic context, "gene loss" typically refers to the event or fact of genes being lost. Sense 1 "something that is lost" with example "loss of livestock" is similar to "loss of genes" - it treats the loss as referring to the thing lost.

Actually, let me reconsider. "Gene losses" here - in genetics, this would refer to instances of gene loss. The loss of genes.

Sense 1: "something that is lost" - this defines loss as the thing that is lost itself. Example: "the car was a total loss" means the car is the thing lost. Similarly, "gene losses" could mean the genes that are lost.

Sense 3: "the act of losing someone or something" - this defines loss as the event. Example: "everyone expected him to win so his loss was a shock" - here loss is the event.

"Gene losses were critical" - could mean either the genes that were lost, or the events of losing genes were critical. In scientific context, I think it's more about the fact/event of genes being lost, which is critical to tumor development.

Hmm, but looking at the examples:
- Sense 1: "loss of livestock left the rancher bankrupt" - here "loss of livestock" = the livestock that was lost
- Sense 3: "his loss was a shock" - here loss = the event

"Gene losses" in this context - I think it's more about the instances of genes being lost (the deletions), which would be sense 1 (the things lost) or sense 3 (the act).

Actually, in the context, the sentence talks about "both copies of a certain gene were knocked out" and "a second gene were then deleted" - these are the losses. So "gene losses" refers to these instances of genes being knocked out/deleted.

I think sense 1 fits best because "loss of livestock" parallels "gene losses" - both refer to the things (livestock/genes) that are lost. The plural "losses" suggests multiple instances of things being lost.

Wait, but "loss of livestock" is singular, while we have "losses" (plural). Still, the sense is about things that are lost.

Actually, let me think again. "Gene losses" here = losses of genes = the genes that are lost. This aligns with sense 1: "something that is lost."

I'll go with sense 1 (index 1).

Hmm, but sense 3 is "the act of losing someone or something." Gene losses could be the acts of losing genes.

The difference is subtle. Let me look at the examples more carefully:
- Sense 1: "the car was a total loss" (the car is what was lost) - this is the thing lost
- Sense 3: "his loss was a shock" (his losing was a shock) - this is the event

"Gene losses were critical" - I think this means the events/instances of genes being lost were critical. But it could also mean the genes that were lost were critical.

In genetics, when we say "gene losses are critical to cancer development," we're saying the loss of genes (the event/process) is critical. But the surface form "losses" makes it a noun referring to multiple loss events or multiple lost items.

I think the best interpretation is sense 1, because "losses" (plural) most naturally refers to the things that are lost (the genes themselves are lost).

Actually, I'm going to go with sense 1. The "losses" here refers to the genes that are lost (the deletions), which aligns with "something that is lost."

Wait, let me reconsider once more. In the context: "If both copies of a certain gene were knocked out... If both copies of a second gene were then deleted..." These are the gene losses. "Gene losses" = the losses (events) of genes, or the genes that were lost?

"Gene losses were critical to the development of a common tumor" - I read this as: the fact that genes were lost (the losses) was critical. So "losses" = instances of loss.

Hmm, this is tricky. Let me think about which sense is most appropriate.

Sense 1: "something that is lost" - the loss is the thing lost
Sense 3: "the act of losing" - the loss is the act

"Gene losses" in the plural... If it's "the act of losing genes," then "losses" would mean multiple acts of losing. If it's "something that is lost," then "losses" would mean multiple things lost.

Both interpretations are possible. But in scientific context, I think "gene losses" more commonly refers to the events or instances of genes being lost.

Actually, looking at similar usage: "loss of biodiversity" uses sense 1 (the biodiversity that is lost). "Gene losses" would be similar - the genes that are lost.

I'll go with sense 1.

Final answer: sense_index 1


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: loss
Target surface form: losses
Context:
Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene <t>losses</t> were critical to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy.

Candidate senses:
1. sense_key=loss%1:21:01:: | definition=something that is lost | examples=the car was a total loss; loss of livestock left the rancher bankrupt
2. sense_key=loss%1:22:00:: | definition=gradual decline in amount or activity | examples=weight loss; a serious loss of business
3. sense_key=loss%1:04:00:: | definition=the act of losing someone or something | examples=everyone expected him to win so his loss was a shock
4. sense_key=loss%1:07:00:: | definition=the disadvantage that results from losing something | synonyms=deprivation | examples=his loss of credibility led to his resignation; losing him is no great deprivation
5. sense_key=loss%1:11:01:: | definition=the experience of losing a loved one | examples=he sympathized on the loss of their grandfather
6. sense_key=loss%1:21:00:: | definition=the amount by which the cost of a business exceeds its revenue | synonyms=red ink, red | examples=the company operated at a loss last year; the company operated in the red last year
7. sense_key=loss%1:11:00:: | definition=military personnel lost by death or capture | synonyms=personnel casualty
8. sense_key=loss%1:11:02:: | definition=euphemistic expressions for death | synonyms=passing, departure, exit, expiration, going, release | examples=thousands mourned his passing

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

[Assistant] {"sense_index": 1}{"sense_index": 1}

[User] Your previous answer was invalid. Choose one candidate index between 1 and 8. Return only valid JSON exactly like {"sense_index": 1}.

content: {"sense_index": 1}{"sense_index": 1}

reasoning_content:
The context discusses gene losses in the context of cancer development. Genes are being "lost" or knocked out/deleted. The quote says "gene losses were critical to the development of a common tumor." This refers to genes that are lost - i.e., the genes themselves are things that are lost. This maps to sense 1: "something that is lost" - like the car example where the car was a total loss. Here, the genes are the things that are lost (deleted/knocked out).

Sense 1 is the best fit: the genes are the things being lost.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: critical
Target surface form: critical
Context:
Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were <t>critical</t> to the development of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy.

Candidate senses:
1. sense_key=critical%3:00:01:: | definition=marked by a tendency to find and call attention to errors and flaws | examples=a critical attitude
2. sense_key=critical%3:00:04:: | definition=at or of a point at which a property or phenomenon suffers an abrupt change especially having enough mass to sustain a chain reaction | examples=a critical temperature of water is 100 degrees C--its boiling point at standard atmospheric pressure; critical mass
3. sense_key=critical%3:00:02:: | definition=characterized by careful evaluation and judgment | examples=a critical reading; a critical dissertation
4. sense_key=critical%5:00:00:indispensable:00 | definition=urgently needed; absolutely necessary | synonyms=vital | examples=a critical element of the plan; critical medical supplies
5. sense_key=critical%5:00:00:crucial:00 | definition=forming or having the nature of a turning point or crisis | synonyms=decisive | examples=a critical point in the campaign; the critical test
6. sense_key=critical%3:00:03:: | definition=being in or verging on a state of crisis or emergency | examples=a critical shortage of food; a critical illness
7. sense_key=critical%3:01:00:: | definition=of or involving or characteristic of critics or criticism | examples=critical acclaim

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context is about gene losses being "critical" to the development of a common tumor. The sentence says "It was the confirming evidence we all needed that gene losses were critical to the development of a common tumor."

Here, "critical" means "absolutely necessary" or "urgently needed" - the gene losses were indispensable/essential for the development of the tumor.

Looking at the candidate senses:

4. sense_key=critical%5:00:00:indispensable:00 | definition=urgently needed; absolutely necessary | synonyms=vital | examples=a critical element of the plan; critical medical supplies

5. sense_key=critical%5:00:00:crucial:00 | definition=forming or having the nature of a turning point or crisis | synonyms=decisive | examples=a critical point in the campaign; the critical test

Both 4 and 5 could apply. The sentence says gene losses were "critical to the development of" cancer - meaning they were necessary/essential. This aligns with sense 4 (indispensable, absolutely necessary).

Sense 5 is more about a turning point or crisis - which could also fit since the gene losses represent a turning point in the progression of the cancer. But the more natural reading here is that the gene losses were necessary/essential for tumor development, which is sense 4.

Actually, let me reconsider. "Critical to the development" - this means the gene losses were essential/necessary for the development. Sense 4 fits better with "urgently needed; absolutely necessary."

I'll go with sense 4.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: development
Target surface form: development
Context:
Gradually, a coherent picture of cancer development emerged. If both copies of a certain gene were knocked out, benign polyps would develop. If both copies of a second gene were then deleted, the polyps would progress to malignancy. It was clear that more than one gene had to be damaged for colon cancer to develop. Their report galvanized other molecular biologists. "It was the confirming evidence we all needed that gene losses were critical to the <t>development</t> of a common tumor, "says Ray White at Howard Hughes Medical Institute in Salt Lake City. But Dr. Vogelstein had yet to nail the identity of the gene that, if damaged, flipped a colon cell into full-blown malignancy.

Candidate senses:
1. sense_key=development%1:04:01:: | definition=act of improving by expanding or enlarging or refining | examples=he congratulated them on their development of a plan to meet the emergency; they funded research and development
2. sense_key=development%1:22:02:: | definition=a process in which something passes by degrees to a different stage (especially a more advanced or mature stage) | synonyms=evolution | examples=the development of his ideas took many years; the evolution of Greek civilization
3. sense_key=development%1:22:01:: | definition=(biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level | synonyms=growth, growing, maturation, ontogeny, ontogenesis | examples=he proposed an indicator of osseous development in children
4. sense_key=development%1:11:01:: | definition=a recent event that has some relevance for the present situation | examples=recent developments in Iraq; what a revolting development!
5. sense_key=development%1:04:02:: | definition=the act of making some area of land or water more profitable or productive or useful | synonyms=exploitation | examples=the development of Alaskan resources; the exploitation of copper deposits
6. sense_key=development%1:15:00:: | definition=a district that has been developed to serve some purpose | examples=such land is practical for small park developments
7. sense_key=development%1:26:00:: | definition=a state in which things are improving; the result of developing (as in the early part of a game of chess) | examples=after he saw the latest development he changed his mind and became a supporter; in chess your should take care of your development before moving your queen
8. sense_key=development%1:22:00:: | definition=processing a photosensitive material in order to make an image visible | synonyms=developing | examples=the development and printing of his pictures took only two hours
9. sense_key=development%1:10:00:: | definition=(music) the section of a composition or movement (especially in sonata form) where the major musical themes are developed and elaborated

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context is about cancer development - specifically, the process by which colon cancer develops from benign polyps to malignancy through gene damage. This is a biological process where something passes by degrees to a more advanced or mature stage (from benign polyps to malignancy).

Let me look at the candidate senses:

1. act of improving by expanding or enlarging or refining - not quite right
2. a process in which something passes by degrees to a different stage (especially a more advanced or mature stage) - synonyms: evolution - this fits well
3. (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level - this is about individual organism growth, like ontogeny

The key distinction is between sense 2 and sense 3. Sense 3 is specifically about an individual organism growing biologically (ontogeny, maturation). Sense 2 is about a process passing by degrees to a different stage (especially more advanced or mature stage).

In this context, "development of a common tumor" refers to the progression of cancer from benign to malignant state - it's the process of disease progression through stages, not the growth of an individual organism. So sense 2 seems more appropriate.

The phrase "development of a common tumor" and "cancer development" here refers to the multi-step process by which cancer develops/progresses through stages, which aligns with sense 2 - "a process in which something passes by degrees to a different stage (especially a more advanced or mature stage)."

I'll go with sense 2.