[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: copy
Target surface form: copies
Context:
But if the genes are damaged -- perhaps by radiation, a chemical or through a chance accident in cell division -- their growth-suppressing proteins no longer work, and cells normally under control turn malignant. The newly identified genes differ from a family of genes discovered in the early 1980s called oncogenes. Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both <t>copies</t> must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop.

Candidate senses:
1. sense_key=copy%1:10:00:: | definition=a reproduction of a written record (e.g. of a legal or school record) | synonyms=transcript
2. sense_key=copy%1:06:00:: | definition=a thing made to be similar or identical to another thing | examples=she made a copy of the designer dress; the clone was a copy of its ancestor
3. sense_key=copy%1:10:01:: | definition=matter to be printed; exclusive of graphical materials | synonyms=written matter
4. sense_key=copy%1:10:02:: | definition=material suitable for a journalistic account | examples=catastrophes make good copy

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer JSON only. Need disambiguate copy copies in genetics context. Candidates: 1 transcript record, 2 thing made similar/identical to another thing, 3 matter to be printed, 4 journalistic material. Context: genes inherited in two copies, one from each parent. A copy of a gene is an instance/duplicate identical/similar. Sense 2 best: a thing made to be similar or identical to another thing. Need return {"sense_index": 2}. Ensure only JSON no extra.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: impaired
Target surface form: impaired
Context:
But if the genes are damaged -- perhaps by radiation, a chemical or through a chance accident in cell division -- their growth-suppressing proteins no longer work, and cells normally under control turn malignant. The newly identified genes differ from a family of genes discovered in the early 1980s called oncogenes. Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be <t>impaired</t>. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop.

Candidate senses:
1. sense_key=impaired%3:00:00:: | definition=diminished in strength, quality, or utility | examples=impaired eyesight
2. sense_key=impaired%5:00:00:unfit:01 | definition=mentally or physically unfit | synonyms=afflicted

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

finish_reason: stop

role: assistant

reasoning_content: The target word "impaired" in context refers to gene copies being damaged/diminished in function. Sense 1: diminished in strength, quality, or utility — fits genes whose function is compromised. Sense 2: mentally or physically unfit — refers to people, not genes. Best is sense 1.

format: unknown

native_finish_reason: stop

provider: Moonshot AI

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: person
Target surface form: person
Context:
The newly identified genes differ from a family of genes discovered in the early 1980s called oncogenes. Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A <t>person</t> who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis.

Candidate senses:
1. sense_key=person%1:03:00:: | definition=a human being | synonyms=individual, someone, somebody, mortal, soul | examples=there was too much for one person to do
2. sense_key=person%1:08:00:: | definition=a human body (usually including the clothing) | examples=a weapon was hidden on his person
3. sense_key=person%1:10:00:: | definition=a grammatical category used in the classification of pronouns, possessive determiners, and verb forms according to whether they indicate the speaker, the addressee, or a third party | examples=stop talking about yourself in the third person

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context says "A person who is born with one defective copy..." clearly referring to a human being/individual. Sense 1. Need return only JSON.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: bear
Target surface form: born
Context:
The newly identified genes differ from a family of genes discovered in the early 1980s called oncogenes. Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is <t>born</t> with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis.

Candidate senses:
1. sense_key=bear%2:42:01:: | definition=have | examples=bear a resemblance; bear a signature
2. sense_key=bear%2:29:01:: | definition=cause to be born | synonyms=give birth, deliver, birth, have | examples=My wife had twins yesterday!
3. sense_key=bear%2:31:00:: | definition=put up with something or somebody unpleasant | synonyms=digest, endure, stick out, stomach, stand, tolerate | examples=I cannot bear his constant criticism; The new secretary had to endure a lot of unprofessional remarks
4. sense_key=bear%2:35:00:: | definition=move while holding up or supporting | examples=Bear gifts; bear a heavy load
5. sense_key=bear%2:36:00:: | definition=bring forth, | synonyms=turn out | examples=The apple tree bore delicious apples this year; The unidentified plant bore gorgeous flowers
6. sense_key=bear%2:40:02:: | definition=take on as one's own the expenses or debts of another person | synonyms=take over, accept, assume | examples=I'll accept the charges; She agreed to bear the responsibility
7. sense_key=bear%2:42:14:: | definition=contain or hold; have within | synonyms=hold, carry, contain | examples=The jar carries wine; The canteen holds fresh water
8. sense_key=bear%2:40:01:: | definition=bring in | synonyms=yield, pay | examples=interest-bearing accounts; How much does this savings certificate pay annually?
9. sense_key=bear%2:29:02:: | definition=have on one's person | synonyms=wear | examples=He wore a red ribbon; bear a scar
10. sense_key=bear%2:41:00:: | definition=behave in a certain manner | synonyms=behave, acquit, deport, conduct, comport, carry | examples=She carried herself well; he bore himself with dignity
11. sense_key=bear%2:40:00:: | definition=have rightfully; of rights, titles, and offices | synonyms=hold | examples=She bears the title of Duchess; He held the governorship for almost a decade
12. sense_key=bear%2:35:01:: | definition=support or hold in a certain manner | synonyms=hold, carry | examples=She holds her head high; He carried himself upright
13. sense_key=bear%2:29:00:: | definition=be pregnant with | synonyms=have a bun in the oven, carry, gestate, expect | examples=She is bearing his child; The are expecting another child in January

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "born" (surface form of "bear"). Context: "A person who is born with one defective copy of a suppressor gene..." This is clearly about being given birth to / coming into existence with a genetic condition. The passive "is born with" corresponds to the sense "cause to be born" / "give birth" (bear%2:29:01::), even though it's passive. The phrase "born with" means from birth. Among candidate senses, sense 2 (bear%2:29:01:: cause to be born, synonyms give birth, deliver, birth, have) is the best fit.

Need output only JSON {"sense_index": 2}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: copy
Target surface form: copy
Context:
The newly identified genes differ from a family of genes discovered in the early 1980s called oncogenes. Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective <t>copy</t> of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis.

Candidate senses:
1. sense_key=copy%1:10:00:: | definition=a reproduction of a written record (e.g. of a legal or school record) | synonyms=transcript
2. sense_key=copy%1:06:00:: | definition=a thing made to be similar or identical to another thing | examples=she made a copy of the designer dress; the clone was a copy of its ancestor
3. sense_key=copy%1:10:01:: | definition=matter to be printed; exclusive of graphical materials | synonyms=written matter
4. sense_key=copy%1:10:02:: | definition=material suitable for a journalistic account | examples=catastrophes make good copy

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context discusses genes inherited in two copies, one from each parent. A "copy" of a gene is a thing made to be similar/identical to another thing (one instance of the gene). Sense 2 fits: a thing made to be similar or identical to another thing, example includes clone was a copy of its ancestor. Not transcript/written matter/journalistic. Return JSON only.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: copy
Target surface form: copy
Context:
The newly identified genes differ from a family of genes discovered in the early 1980s called oncogenes. Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one <t>copy</t> is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis.

Candidate senses:
1. sense_key=copy%1:10:00:: | definition=a reproduction of a written record (e.g. of a legal or school record) | synonyms=transcript
2. sense_key=copy%1:06:00:: | definition=a thing made to be similar or identical to another thing | examples=she made a copy of the designer dress; the clone was a copy of its ancestor
3. sense_key=copy%1:10:01:: | definition=matter to be printed; exclusive of graphical materials | synonyms=written matter
4. sense_key=copy%1:10:02:: | definition=material suitable for a journalistic account | examples=catastrophes make good copy

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context is about genes inherited in two copies, one from each parent. The target "copy" refers to one instance of a gene that is similar/identical to another thing (the gene). Among candidates, sense 2 "a thing made to be similar or identical to another thing" fits best: a copy of a gene. Other senses are about written records, printed matter, journalistic material. So answer {"sense_index": 2}. Need only JSON.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: damage
Target surface form: damaged
Context:
The newly identified genes differ from a family of genes discovered in the early 1980s called oncogenes. Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is <t>damaged</t> early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis.

Candidate senses:
1. sense_key=damage%2:30:00:: | definition=inflict damage upon | examples=The snow damaged the roof; She damaged the car when she hit the tree
2. sense_key=damage%2:30:01:: | definition=suffer or be susceptible to damage | examples=These fine china cups damage easily

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word "damaged" in context: "one copy is damaged early in life". This refers to a gene copy being harmed/impaired. Sense 1 is "inflict damage upon" (transitive, something causes damage to something). Sense 2 is "suffer or be susceptible to damage" (intransitive, the thing undergoes damage).

In "one copy is damaged early in life", passive construction: the copy suffers damage / is harmed. The gene copy is susceptible to/suffers damage. Actually passive "is damaged" comes from transitive sense 1 "something damages the copy" -> the copy is damaged. But WordNet sense 2 is intransitive "suffer or be susceptible to damage" e.g. "these cups damage easily".

Need choose between 1 and 2. The verb here is passive of transitive damage: one copy is damaged (by something) early in life. The subject "one copy" is the patient receiving damage; semantically it suffers damage. WordNet sense 2 definition "suffer or be susceptible to damage" seems to match the intransitive patient subject, but the surface is passive. In WSD tasks, passive of transitive usually still maps to transitive sense 1 (inflict damage upon) because the lexical sense is the causative. Example "the tumor-suppressor gene has been damaged" also passive. Candidate examples sense 1 include damaged the roof/car. In context "the tumor-suppressor gene has been damaged" = something has inflicted damage upon it. So sense 1 likely.

Need output only JSON object. No hedging. Final only JSON.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: early
Target surface form: early
Context:
The newly identified genes differ from a family of genes discovered in the early 1980s called oncogenes. Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged <t>early</t> in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis.

Candidate senses:
1. sense_key=early%4:02:01:: | definition=during an early stage | synonyms=early on | examples=early on in her career
2. sense_key=early%4:02:00:: | definition=before the usual time or the time expected | synonyms=ahead of time, too soon | examples=she graduated early; the house was completed ahead of time
3. sense_key=early%4:02:02:: | definition=in good time | synonyms=betimes | examples=he awoke betimes that morning

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to disambiguate the word "early" in the context. The phrase is "in whom one copy is damaged early in life".

The target word is "early" used as an adverb modifying "damaged" - "damaged early in life". This means during an early stage of life.

Sense 1: during an early stage (early on) - examples "early on in her career". This fits "early in life" = during an early stage of life.
Sense 2: before the usual time or expected - ahead of time, too soon. Doesn't fit; it's not about being damaged before expected.
Sense 3: in good time - betimes. Doesn't fit.

The best sense is 1.

Return only JSON {"sense_index": 1}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: life
Target surface form: life
Context:
The newly identified genes differ from a family of genes discovered in the early 1980s called oncogenes. Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in <t>life</t>, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis.

Candidate senses:
1. sense_key=life%1:26:01:: | definition=a characteristic state or mode of living | examples=social life; city life
2. sense_key=life%1:09:00:: | definition=the experience of being alive; the course of human events and activities | synonyms=living | examples=he could no longer cope with the complexities of life
3. sense_key=life%1:26:02:: | definition=the course of existence of an individual; the actions and events that occur in living | examples=he hoped for a new life in Australia; he wanted to live his own life without interference from others
4. sense_key=life%1:26:00:: | definition=the condition of living or the state of being alive | synonyms=animation, living, aliveness | examples=while there's life there's hope; life depends on many chemical and physical processes
5. sense_key=life%1:28:00:: | definition=the period during which something is functional (as between birth and death) | synonyms=lifetime, lifespan | examples=the battery had a short life; he lived a long and happy life
6. sense_key=life%1:28:01:: | definition=the period between birth and the present time | examples=I have known him all his life
7. sense_key=life%1:28:02:: | definition=the period from the present until death | examples=he appointed himself emperor for life
8. sense_key=life%1:18:00:: | definition=a living person | examples=his heroism saved a life
9. sense_key=life%1:07:01:: | definition=animation and energy in action or expression | synonyms=liveliness, spirit, sprightliness | examples=it was a heavy play and the actors tried in vain to give life to it
10. sense_key=life%1:03:00:: | definition=living things collectively | examples=the oceans are teeming with life
11. sense_key=life%1:19:00:: | definition=the organic phenomenon that distinguishes living organisms from nonliving ones | examples=there is no life on the moon
12. sense_key=life%1:10:00:: | definition=an account of the series of events making up a person's life | synonyms=biography, life story, life history
13. sense_key=life%1:16:00:: | definition=a motive for living | examples=pottery was his life
14. sense_key=life%1:28:03:: | definition=a prison term lasting as long as the prisoner lives | synonyms=life sentence | examples=he got life for killing the guard

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The phrase "damaged early in life" means early during the period of a person's existence/lifetime, from birth onward. Best sense: period during which something is functional between birth and death (lifetime/lifespan), sense 5. Could be sense 6 period between birth and present? "early in life" idiomatic means early in one's lifetime, not necessarily birth to present. Sense 5 examples include "he lived a long and happy life" and battery life; more general lifetime. Answer JSON only. Ensure not sense key. Final only JSON.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: especially
Target surface form: especially
Context:
The newly identified genes differ from a family of genes discovered in the early 1980s called oncogenes. Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is <t>especially</t> prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis.

Candidate senses:
1. sense_key=especially%4:02:00:: | definition=to a distinctly greater extent or degree than is common | synonyms=particularly, peculiarly, specially | examples=he was particularly fussy about spelling; a particularly gruesome attack
2. sense_key=especially%4:02:01:: | definition=in a special manner | synonyms=specially | examples=a specially arranged dinner

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context: "A person who is born with one defective copy... is especially prone to cancer because he need only lose the other copy..." Here especially means to a distinctly greater extent/degree than common — more prone than others. Sense 1: to a distinctly greater extent or degree than is common (particularly). Sense 2: in a special manner. The adverb modifies prone, indicating degree. So sense_index 1. Need return only JSON. Ensure no extra text.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
The newly identified genes differ from a family of genes discovered in the early 1980s called oncogenes. Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to <t>cancer</t> because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context is medical, discussing genes, oncogenes, tumor-suppressor genes, malignant cells, and cancer diagnosis. The target word "cancer" clearly refers to the disease: malignant growth/tumor caused by abnormal uncontrolled cell division. That's sense 1. Need output only JSON {"sense_index": 1}. Ensure no extra text.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: only
Target surface form: only
Context:
The newly identified genes differ from a family of genes discovered in the early 1980s called oncogenes. Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need <t>only</t> lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis.

Candidate senses:
1. sense_key=only%4:02:02:: | definition=and nothing more | synonyms=merely, simply, just, but | examples=I was merely asking; it is simply a matter of time
2. sense_key=only%4:02:01:: | definition=without any others being included or involved | synonyms=entirely, exclusively, solely, alone | examples=was entirely to blame; a school devoted entirely to the needs of problem children
3. sense_key=only%4:02:00:: | definition=with nevertheless the final result | examples=He arrived only to find his wife dead; We won only to lose again in the next round
4. sense_key=only%4:02:04:: | definition=in the final outcome | examples=These news will only make you more upset
5. sense_key=only%4:02:06:: | definition=except that | examples=It was the same story; only this time she came out better
6. sense_key=only%4:02:03:: | definition=never except when | synonyms=only if, only when | examples=call me only if your cold gets worse
7. sense_key=only%4:02:05:: | definition=as recently as | examples=I spoke to him only an hour ago

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The user wants WSD for 'only' in: "he need only lose the other copy for a cancer to develop." Means he merely/just has to lose the other copy; nothing more required. Sense 1 'and nothing more' (merely, simply, just, but). Need return JSON only. Ensure no sense key. Final exactly {"sense_index": 1}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: lose
Target surface form: lose
Context:
The newly identified genes differ from a family of genes discovered in the early 1980s called oncogenes. Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only <t>lose</t> the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis.

Candidate senses:
1. sense_key=lose%2:40:02:: | definition=fail to keep or to maintain; cease to have, either physically or in an abstract sense | examples=She lost her purse when she left it unattended on her seat
2. sense_key=lose%2:33:00:: | definition=fail to win | examples=We lost the battle but we won the war
3. sense_key=lose%2:37:00:: | definition=suffer the loss of a person through death or removal | examples=She lost her husband in the war; The couple that wanted to adopt the child lost her when the biological parents claimed her
4. sense_key=lose%2:35:00:: | definition=place (something) where one cannot find it again | synonyms=misplace, mislay | examples=I misplaced my eyeglasses
5. sense_key=lose%2:40:01:: | definition=miss from one's possessions; lose sight of | examples=I've lost my glasses again!
6. sense_key=lose%2:39:00:: | definition=allow to go out of sight | examples=The detective lost the man he was shadowing after he had to stop at a red light
7. sense_key=lose%2:40:06:: | definition=fail to make money in a business; make a loss or fail to profit | synonyms=turn a loss | examples=I lost thousands of dollars on that bad investment!; The company turned a loss after the first year
8. sense_key=lose%2:40:00:: | definition=fail to get or obtain | examples=I lost the opportunity to spend a year abroad
9. sense_key=lose%2:33:01:: | definition=retreat | synonyms=fall back, drop off, fall behind, recede
10. sense_key=lose%2:39:01:: | definition=fail to perceive or to catch with the senses or the mind | synonyms=miss | examples=I missed that remark; She missed his point
11. sense_key=lose%2:30:03:: | definition=be set at a disadvantage | synonyms=suffer | examples=This author really suffers in translation

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context: person with one defective copy of tumor-suppressor gene needs only "lose the other copy" for cancer to develop. Meaning cease to have / fail to keep a functional gene copy, abstract/physical. Best sense 1: fail to keep or maintain; cease to have. Need return JSON only. Ensure no sense key. Sense index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: other
Target surface form: other
Context:
The newly identified genes differ from a family of genes discovered in the early 1980s called oncogenes. Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the <t>other</t> copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis.

Candidate senses:
1. sense_key=other%3:00:00:: | definition=not the same one or ones already mentioned or implied; - the White Queen | examples=today isn't any other day; the construction of highways and other public works
2. sense_key=other%5:00:00:past:00 | definition=recently past | examples=the other evening
3. sense_key=other%5:00:02:past:00 | definition=belonging to the distant past | synonyms=early, former | examples=the early inhabitants of Europe; former generations
4. sense_key=other%5:00:00:strange:00 | definition=very unusual; different in character or quality from the normal or expected; - Lance Morrow | examples=a strange, other dimension...where his powers seemed to fail

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The target word is "other" in context: "he need only lose the other copy". The sentence discusses two copies of a suppressor gene inherited from parents. If one copy is defective/damaged, the person only needs to lose the other copy (the second remaining one) for cancer to develop. This is "not the same one already mentioned" - the remaining one of two. Sense 1 fits: not the same one or ones already mentioned or implied. The other senses (recently past, distant past, strange) don't fit. Answer JSON with sense_index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: copy
Target surface form: copy
Context:
The newly identified genes differ from a family of genes discovered in the early 1980s called oncogenes. Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other <t>copy</t> for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis.

Candidate senses:
1. sense_key=copy%1:10:00:: | definition=a reproduction of a written record (e.g. of a legal or school record) | synonyms=transcript
2. sense_key=copy%1:06:00:: | definition=a thing made to be similar or identical to another thing | examples=she made a copy of the designer dress; the clone was a copy of its ancestor
3. sense_key=copy%1:10:01:: | definition=matter to be printed; exclusive of graphical materials | synonyms=written matter
4. sense_key=copy%1:10:02:: | definition=material suitable for a journalistic account | examples=catastrophes make good copy

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context is about genes inherited in two copies, one from each parent. The target "copy" refers to one instance/version of a gene that is similar/identical to another. Sense 2: a thing made to be similar or identical to another thing fits best. Other senses about written records, printed matter, journalistic material are irrelevant. Need return only JSON. Final only JSON.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
The newly identified genes differ from a family of genes discovered in the early 1980s called oncogenes. Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a <t>cancer</t> to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context is clearly medical about malignant tumors, oncogenes, tumor-suppressor genes. The target 'a cancer to develop' refers to a malignant growth/tumor. Sense 1. Need return only JSON. No extra. Ensure sense_index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: develop
Target surface form: develop
Context:
The newly identified genes differ from a family of genes discovered in the early 1980s called oncogenes. Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to <t>develop</t>. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis.

Candidate senses:
1. sense_key=develop%2:36:01:: | definition=make something new, such as a product or a mental or artistic creation | examples=Her company developed a new kind of building material that withstands all kinds of weather; They developed a new technique
2. sense_key=develop%2:36:00:: | definition=work out | synonyms=evolve, germinate | examples=We have developed a new theory of evolution
3. sense_key=develop%2:30:06:: | definition=gain through experience | synonyms=acquire, evolve | examples=I acquired a strong aversion to television; Children must develop a sense of right and wrong
4. sense_key=develop%2:29:00:: | definition=come to have or undergo a change of (physical features and attributes) | synonyms=grow, produce, get, acquire | examples=He grew a beard; The patient developed abdominal pains
5. sense_key=develop%2:42:00:: | definition=come into existence; take on form or shape | synonyms=originate, arise, rise, uprise, spring up, grow | examples=A new religious movement originated in that country; a love that sprang up from friendship
6. sense_key=develop%2:30:04:: | definition=change the use of and make available or usable | synonyms=build up | examples=develop land; The country developed its natural resources
7. sense_key=develop%2:32:00:: | definition=elaborate, as of theories and hypotheses | synonyms=explicate, formulate | examples=Could you develop the ideas in your thesis
8. sense_key=develop%2:31:00:: | definition=create by training and teaching | synonyms=train, prepare, educate | examples=The old master is training world-class violinists; we develop the leaders for the future
9. sense_key=develop%2:30:05:: | definition=be gradually disclosed or unfolded; become manifest | examples=The plot developed slowly
10. sense_key=develop%2:30:00:: | definition=grow, progress, unfold, or evolve through a process of evolution, natural growth, differentiation, or a conducive environment | examples=A flower developed on the branch; The country developed into a mighty superpower
11. sense_key=develop%2:30:09:: | definition=become technologically advanced | synonyms=modernize, modernise | examples=Many countries in Asia are now developing at a very fast pace; Viet Nam is modernizing rapidly
12. sense_key=develop%2:30:01:: | definition=cause to grow and differentiate in ways conforming to its natural development | synonyms=make grow | examples=The perfect climate here develops the grain; He developed a new kind of apple
13. sense_key=develop%2:36:09:: | definition=generate gradually | examples=We must develop more potential customers; develop a market for the new mobile phone
14. sense_key=develop%2:30:10:: | definition=grow emotionally or mature | synonyms=grow | examples=The child developed beautifully in her new kindergarten; When he spent a summer at camp, the boy grew noticeably and no longer showed some of his old adolescent behavior
15. sense_key=develop%2:39:00:: | definition=make visible by means of chemical solutions | examples=Please develop this roll of film for me
16. sense_key=develop%2:35:04:: | definition=superimpose a three-dimensional surface on a plane without stretching, in geometry
17. sense_key=develop%2:33:03:: | definition=move one's pieces into strategically more advantageous positions | examples=Spassky developed quickly
18. sense_key=develop%2:33:02:: | definition=move into a strategically more advantageous position | examples=develop the rook
19. sense_key=develop%2:30:13:: | definition=elaborate by the unfolding of a musical idea and by the working out of the rhythmic and harmonic changes in the theme | examples=develop the melody and change the key
20. sense_key=develop%2:30:03:: | definition=happen | synonyms=break, recrudesce | examples=Report the news as it develops; These political movements recrudesce from time to time
21. sense_key=develop%2:30:12:: | definition=expand in the form of a series | examples=Develop the function in the following form

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context: "he need only lose the other copy for a cancer to develop". Here cancer develops = comes into existence / arises. Target is intransitive, a cancer comes into existence. Sense 5: come into existence; take on form or shape; synonyms originate, arise... Example "A new religious movement originated". Also sense 20 happen (break, recrudesce) "Report the news as it develops". For a cancer to develop, best is come into existence/arise (sense 5). Sense 4 is undergo change physical features e.g. patient developed abdominal pains (come to have), but subject would be person develops cancer maybe. Here "for a cancer to develop" means for cancer to arise/form. Sense 5. Need output only JSON. Ensure not key. Final {"sense_index": 5}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: emerging
Target surface form: Emerging
Context:
Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. <t>Emerging</t> genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings.

Candidate senses:
1. sense_key=emerging%5:00:00:future:00 | definition=coming to maturity | synonyms=rising | examples=the rising generation
2. sense_key=emerging%5:00:00:nascent:00 | definition=coming into existence | synonyms=emergent | examples=an emergent republic

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The target word is "Emerging" in context "Emerging genetic tests will be able to spot such cancer-susceptible individuals". This means genetic tests that are newly coming into existence/development. Sense 1 "coming to maturity" (rising generation) implies developing toward maturity. Sense 2 "coming into existence" (nascent, emergent) means just beginning to exist. "Emerging genetic tests" are new tests just coming into existence/being developed. Best is sense 2. Need output JSON only with sense_index. No hedge. Ensure exact JSON.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: genetic
Target surface form: genetic
Context:
Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging <t>genetic</t> tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings.

Candidate senses:
1. sense_key=genetic%5:00:00:inheritable:00 | definition=occurring among members of a family usually by heredity | synonyms=familial, hereditary, inherited, transmitted, transmissible | examples=an inherited disease; familial traits
2. sense_key=genetic%3:01:02:: | definition=of or relating to or produced by or being a gene | synonyms=genic, genetical | examples=genic combinations; genetic code
3. sense_key=genetic%3:01:01:: | definition=pertaining to or referring to origin | examples=genetic history reconstructs the origins of a literary work
4. sense_key=genetic%3:01:00:: | definition=of or relating to the science of genetics | synonyms=genetical | examples=genetic research

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "genetic" in "Emerging genetic tests will be able to spot such cancer-susceptible individuals".

Context: tests that examine genes/DNA to identify inherited defective copies of tumor-suppressor genes.

Candidate senses:
1. inheritable/hereditary - occurring among family by heredity
2. of or relating to or produced by or being a gene - genic
3. pertaining to origin
4. of or relating to science of genetics

"Genetic tests" = tests relating to genes/DNA, detecting gene defects. This is sense 2 (of or relating to genes). It could be sense 4 (genetics science) but "genetic testing" is typically about genes directly. Sense 2 best: produced by/being a gene, relating to genes. The tests spot gene defects. Answer 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: able
Target surface form: able
Context:
Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be <t>able</t> to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings.

Candidate senses:
1. sense_key=able%3:00:00:: | definition=(usually followed by `to') having the necessary means or skill or know-how or authority to do something | examples=able to swim; she was able to program her computer
2. sense_key=able%5:00:00:competent:00 | definition=have the skills and qualifications to do things well | synonyms=capable | examples=able teachers; a capable administrator
3. sense_key=able%5:00:00:capable:00 | definition=having inherent physical or mental ability or capacity | examples=able to learn; human beings are able to walk on two feet
4. sense_key=able%5:00:00:fit:01 | definition=having a strong healthy body | synonyms=able-bodied | examples=an able seaman; every able-bodied young man served in the army

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We need answer only JSON. Need determine sense for 'able' in context: "Emerging genetic tests will be able to spot such cancer-susceptible individuals". Need choose best sense among 1-4. Analyze carefully.

Target lemma able, surface able, followed by to spot. Candidate senses:
1 usually followed by to: having necessary means or skill or know-how or authority to do something. examples able to swim; she was able to program her computer.
3 having inherent physical or mental ability or capacity; examples able to learn; humans are able to walk on two feet.
Context: tests will be able to spot individuals = have capability/means to do something due to emerging technology. Which sense? Need fine-grained WSD. Sense 1 is broader (means/skill/know-how/authority) usually followed by to. Sense 3 is inherent physical or mental ability/capacity. Genetic tests are inanimate tools, not inherent physical/mental ability. They will have the necessary means (technological capability) to spot. Sense 1 best. Need final exactly JSON only. Ensure no extra. Use sense_index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: individual
Target surface form: individuals
Context:
Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible <t>individuals</t>, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings.

Candidate senses:
1. sense_key=individual%1:03:00:: | definition=a human being | synonyms=person, someone, somebody, mortal, soul | examples=there was too much for one person to do
2. sense_key=individual%1:18:00:: | definition=a single organism

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The target word "individuals" in context refers to cancer-susceptible people/human beings identified by genetic tests. The passage is about persons born with defective gene copies. Sense 1 "a human being" (person, someone, somebody, mortal, soul) fits best, as opposed to a single organism which is broader biological. Need return only JSON {"sense_index": 1}. Ensure no extra text.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: believe
Target surface form: believe
Context:
Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists <t>believe</t> is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings.

Candidate senses:
1. sense_key=believe%2:31:00:: | definition=accept as true; take to be true | examples=I believed his report; We didn't believe his stories from the War
2. sense_key=believe%2:31:04:: | definition=judge or regard; look upon; judge | synonyms=think, consider, conceive | examples=I think he is very smart; I believe her to be very smart
3. sense_key=believe%2:31:03:: | definition=be confident about something | synonyms=trust | examples=I believe that he will come back from the war
4. sense_key=believe%2:31:01:: | definition=follow a credo; have a faith; be a believer | examples=When you hear his sermons, you will be able to believe, too
5. sense_key=believe%2:31:02:: | definition=credit with veracity | examples=You cannot believe this man; Should we believe a publication like the National Enquirer?

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context: "ushering in what some scientists believe is a new age of predictive cancer diagnosis." Here "believe" is used as judge/regard/think — scientists think/consider that it is a new age. It's an opinion/judgment, not accepting a report as true, not confidence/trust, not faith, not crediting veracity. Sense 2 fits best: judge or regard; look upon; judge (think, consider, conceive). Return JSON {"sense_index": 2}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: new
Target surface form: new
Context:
Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a <t>new</t> age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings.

Candidate senses:
1. sense_key=new%3:00:00:: | definition=not of long duration; having just (or relatively recently) come into being or been made or acquired or discovered | examples=a new law; new cars
2. sense_key=new%5:00:00:original:00 | definition=original and of a kind not seen before | synonyms=fresh, novel | examples=the computer produced a completely novel proof of a well-known theorem
3. sense_key=new%5:00:00:inexperienced:00 | definition=lacking training or experience | synonyms=raw | examples=the new men were eager to fight; raw recruits
4. sense_key=new%5:00:00:unprecedented:00 | definition=having no previous example or precedent or parallel | synonyms=unexampled | examples=a time of unexampled prosperity
5. sense_key=new%5:00:00:other:00 | definition=other than the former one(s); different | examples=they now have a new leaders; my new car is four years old but has only 15,000 miles on it
6. sense_key=new%3:00:09:: | definition=unaffected by use or exposure | examples=it looks like new
7. sense_key=new%5:00:02:original:00 | definition=(of a new kind or fashion) gratuitously new | synonyms=newfangled | examples=newfangled ideas; she buys all these new-fangled machines and never uses them
8. sense_key=new%5:00:02:late:01 | definition=in use after medieval times | examples=New Eqyptian was the language of the 18th to 21st dynasties
9. sense_key=new%5:00:01:late:01 | definition=used of a living language; being the current stage in its development | synonyms=Modern | examples=Modern English; New Hebrew is Israeli Hebrew
10. sense_key=new%5:00:00:early:02 | definition=(of crops) harvested at an early stage of development; before complete maturity | synonyms=young | examples=new potatoes; young corn
11. sense_key=new%5:00:00:unaccustomed:00 | definition=unfamiliar | examples=new experiences; experiences new to him

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target is "new" in "ushering in what some scientists believe is a new age of predictive cancer diagnosis." Need choose best sense.

Context: emerging genetic tests will spot cancer-susceptible individuals, ushering in a new age of predictive cancer diagnosis. Means a recently beginning era, not of long duration; just come into being. Not original/novel kind? "new age" idiom means a new period, recently come into being. Sense 1: not of long duration; having just come into being. Sense 4 unprecedented: having no previous example. "new age" could imply unprecedented era? But context says tests emerging will usher in new age; likely age that has recently begun / not existed before. WordNet sense 1 examples a new law; new cars: recently made/acquired/discovered. For abstract "new age", sense 1 fits: recently come into being. Sense 2 original and of a kind not seen before (novel) could apply to a new kind of diagnosis, but phrase "new age" refers temporal period. Sense 4 unprecedented is stronger: no previous example or parallel. Scientists believe a new age of predictive diagnosis, maybe unprecedented? Need choose single best.

Need answer JSON only. Decide sense_index 1. It is the generic temporal/recency sense. "new findings" later also sense 1/2, but target first. "new age" = era just beginning. Use 1.

Ensure final only JSON.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: age
Target surface form: age
Context:
Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new <t>age</t> of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings.

Candidate senses:
1. sense_key=age%1:07:00:: | definition=how long something has existed | examples=it was replaced because of its age
2. sense_key=age%1:28:02:: | definition=an era of history having some distinctive feature | synonyms=historic period | examples=we live in a litigious age
3. sense_key=age%1:28:00:: | definition=a time of life (usually defined in years) at which some particular qualification or power arises | synonyms=eld | examples=she was now of school age; tall for his eld
4. sense_key=age%1:28:03:: | definition=a prolonged period of time | synonyms=long time, years | examples=we've known each other for ages; I haven't been there for years and years
5. sense_key=age%1:28:01:: | definition=a late time of life | synonyms=old age, years, eld, geezerhood | examples=old age is not for sissies; he's showing his years

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The target phrase is "a new age of predictive cancer diagnosis." This refers to an era/period in history marked by a distinctive feature (predictive diagnosis). Sense 2 is "an era of history having some distinctive feature" with example "we live in a litigious age". This matches best. Need output only JSON.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive <t>cancer</t> diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The target word "cancer" in context is clearly about the medical disease: malignant growth, oncogenes, tumor-suppressor genes, cancer diagnosis. The best sense is 1 (malignant neoplastic disease). Need return only JSON object. Ensure no sense key. Final only JSON.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: first
Target surface form: first
Context:
In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the <t>first</t> beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births.

Candidate senses:
1. sense_key=first%3:00:00:: | definition=preceding all others in time or space or degree | examples=the first house on the right; the first day of spring
2. sense_key=first%5:00:00:ordinal:00 | definition=indicating the beginning unit in a series | synonyms=1st
3. sense_key=first%5:00:02:opening:00 | definition=serving to set in motion | synonyms=inaugural, initiative, initiatory, maiden | examples=the magazine's inaugural issue; the initiative phase in the negotiations
4. sense_key=first%5:00:01:opening:00 | definition=serving to begin | synonyms=beginning | examples=the beginning canto of the poem; the first verse
5. sense_key=first%5:00:00:best:00 | definition=ranking above all others | synonyms=foremost, world-class | examples=was first in her class; the foremost figure among marine artists
6. sense_key=first%3:00:03:: | definition=highest in pitch or chief among parts or voices or instruments or orchestra sections | examples=first soprano; the first violin section

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "first" in "among the first beneficiaries of the new findings." This means preceding all others in time - they are among the earliest people to benefit. Sense 1: preceding all others in time or space or degree. Sense 2 is ordinal beginning unit in a series (like 1st). "Among the first beneficiaries" = earliest in time, preceding others. Best is sense 1.

Need output only JSON.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: beneficiary
Target surface form: beneficiaries
Context:
In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first <t>beneficiaries</t> of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births.

Candidate senses:
1. sense_key=beneficiary%1:18:00:: | definition=the recipient of funds or other benefits | synonyms=donee
2. sense_key=beneficiary%1:10:00:: | definition=the semantic role of the intended recipient who benefits from the happening denoted by the verb in the clause | synonyms=benefactive role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context: "Bill and Bonnie Quinlan are among the first beneficiaries of the new findings." They benefit from new genetic findings/tests. Sense 1 is recipient of funds or other benefits (donee). Sense 2 is semantic role in linguistics. The target is not a semantic role; it's people who receive benefits from findings. So choose sense_index 1. Need output only JSON.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: new
Target surface form: new
Context:
In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the <t>new</t> findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births.

Candidate senses:
1. sense_key=new%3:00:00:: | definition=not of long duration; having just (or relatively recently) come into being or been made or acquired or discovered | examples=a new law; new cars
2. sense_key=new%5:00:00:original:00 | definition=original and of a kind not seen before | synonyms=fresh, novel | examples=the computer produced a completely novel proof of a well-known theorem
3. sense_key=new%5:00:00:inexperienced:00 | definition=lacking training or experience | synonyms=raw | examples=the new men were eager to fight; raw recruits
4. sense_key=new%5:00:00:unprecedented:00 | definition=having no previous example or precedent or parallel | synonyms=unexampled | examples=a time of unexampled prosperity
5. sense_key=new%5:00:00:other:00 | definition=other than the former one(s); different | examples=they now have a new leaders; my new car is four years old but has only 15,000 miles on it
6. sense_key=new%3:00:09:: | definition=unaffected by use or exposure | examples=it looks like new
7. sense_key=new%5:00:02:original:00 | definition=(of a new kind or fashion) gratuitously new | synonyms=newfangled | examples=newfangled ideas; she buys all these new-fangled machines and never uses them
8. sense_key=new%5:00:02:late:01 | definition=in use after medieval times | examples=New Eqyptian was the language of the 18th to 21st dynasties
9. sense_key=new%5:00:01:late:01 | definition=used of a living language; being the current stage in its development | synonyms=Modern | examples=Modern English; New Hebrew is Israeli Hebrew
10. sense_key=new%5:00:00:early:02 | definition=(of crops) harvested at an early stage of development; before complete maturity | synonyms=young | examples=new potatoes; young corn
11. sense_key=new%5:00:00:unaccustomed:00 | definition=unfamiliar | examples=new experiences; experiences new to him

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The target word "new" modifies "findings" in "the new findings." Context: recent research discoveries about cancer genes and genetic tests. "New findings" means recently discovered/acquired findings, not of long duration, just come into being or been discovered. Sense 1 fits: not of long duration; having just come into being or been made or acquired or discovered. Examples include discoveries. Sense 2 original/novel could be tempting but findings are recent rather than unprecedented kind. The phrase "In recent months" supports recency. Answer JSON only. Ensure no extra text. Index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: finding
Target surface form: findings
Context:
In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new <t>findings</t>. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births.

Candidate senses:
1. sense_key=finding%1:04:00:: | definition=the act of determining the properties of something, usually by research or calculation | synonyms=determination | examples=the determination of molecular structures
2. sense_key=finding%1:04:01:: | definition=the decision of a court on issues of fact or law
3. sense_key=finding%1:17:00:: | definition=something that is found | examples=the findings in the gastrointestinal tract indicate that he died several hours after dinner; an area rich in archaeological findings

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context: "Bill and Bonnie Quinlan are among the first beneficiaries of the new findings." This refers to new research discoveries/results about genetic tests and cancer. Sense 1 is act of determining (determination), not fitting "beneficiaries of the new findings" as results. Sense 3 something that is found - research findings. Sense 2 court decision irrelevant. Best is sense 3. Need return JSON only.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: couple
Target surface form: couple
Context:
Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., <t>couple</t> knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby.

Candidate senses:
1. sense_key=couple%1:14:00:: | definition=a pair who associate with one another | synonyms=twosome, duo, duet | examples=the engaged couple; an inseparable twosome
2. sense_key=couple%1:14:01:: | definition=a pair of people who live together | synonyms=mates, match | examples=a married couple from Chicago
3. sense_key=couple%1:23:01:: | definition=a small indefinite number | examples=he's coming for a couple of days
4. sense_key=couple%1:23:00:: | definition=two items of the same kind | synonyms=pair, twosome, twain, brace, span, yoke
5. sense_key=couple%1:17:00:: | definition=(physics) something joined by two equal and opposite forces that act along parallel lines

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context: "The Dedham, Mass., couple knew even before Bonnie became pregnant..." Bill and Bonnie Quinlan are a married couple living together (husband and wife). Sense 2: "a pair of people who live together" with example "a married couple from Chicago" fits perfectly. Sense 1 is "a pair who associate with one another" (engaged couple) — but here they're married, living together, having a child. Best is sense 2.