[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: loss
Target surface form: loss
Context:
But there was no way to prove Dr. Knudson's "two-hit "theory. Back then, scientists had no way of ferreting out specific genes, but under a microscope they could see the 23 pairs of chromosomes in the cells that contain the genes. Occasionally, gross chromosome damage was visible. Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose <t>loss</t> had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared.

Candidate senses:
1. sense_key=loss%1:21:01:: | definition=something that is lost | examples=the car was a total loss; loss of livestock left the rancher bankrupt
2. sense_key=loss%1:22:00:: | definition=gradual decline in amount or activity | examples=weight loss; a serious loss of business
3. sense_key=loss%1:04:00:: | definition=the act of losing someone or something | examples=everyone expected him to win so his loss was a shock
4. sense_key=loss%1:07:00:: | definition=the disadvantage that results from losing something | synonyms=deprivation | examples=his loss of credibility led to his resignation; losing him is no great deprivation
5. sense_key=loss%1:11:01:: | definition=the experience of losing a loved one | examples=he sympathized on the loss of their grandfather
6. sense_key=loss%1:21:00:: | definition=the amount by which the cost of a business exceeds its revenue | synonyms=red ink, red | examples=the company operated at a loss last year; the company operated in the red last year
7. sense_key=loss%1:11:00:: | definition=military personnel lost by death or capture | synonyms=personnel casualty
8. sense_key=loss%1:11:02:: | definition=euphemistic expressions for death | synonyms=passing, departure, exit, expiration, going, release | examples=thousands mourned his passing

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "loss" in the context: "He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer."

This is about genes being missing/deleted from chromosome 13. The "loss" here refers to the absence/disappearance of genes - the disadvantage/deprivation that results from losing something (the gene function).

Let me think about which sense fits best:
1. something that is lost - "the car was a total loss" - this refers to the thing lost itself
2. gradual decline in amount or activity - weight loss - not quite
3. the act of losing someone or something - "everyone expected him to win so his loss was a shock" - act of losing (a game)
4. the disadvantage that results from losing something - deprivation - "his loss of credibility led to his resignation" - this fits! The loss of genes (their absence) had a critical role - it's the disadvantageous state of deprivation
5. experience of losing a loved one - no
6. business loss - no
7. military casualties - no
8. death euphemism - no

The phrase "whose loss had a critical role in setting off the cancer" means the absence/deprivation of the gene function caused cancer. This is the disadvantage resulting from losing something - sense 4 (deprivation).

Actually, let me reconsider. "genes whose loss had a critical role" - the loss of the genes = the fact that they are missing/absent. In genetics, "loss of function" or "loss of heterozygosity" - the loss refers to the state of being deprived of something. Sense 4 is "the disadvantage that results from losing something" with synonym "deprivation". The loss of the tumor suppressor gene function is a deprivation that leads to cancer.

Sense 3 "the act of losing someone or something" could also be plausible - the act/event of losing the genes. But the example "everyone expected him to win so his loss was a shock" is about losing a competition.

Sense 4 "the disadvantage that results from losing something" - "his loss of credibility led to his resignation" - this is more like a consequential deprivation. The gene's loss had a critical role in cancer - the deprivation of the gene (function) caused disease. This fits sense 4 best.

The answer is 4.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: critical
Target surface form: critical
Context:
But there was no way to prove Dr. Knudson's "two-hit "theory. Back then, scientists had no way of ferreting out specific genes, but under a microscope they could see the 23 pairs of chromosomes in the cells that contain the genes. Occasionally, gross chromosome damage was visible. Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a <t>critical</t> role in setting off the cancer. But he did not know which gene or genes had disappeared.

Candidate senses:
1. sense_key=critical%3:00:01:: | definition=marked by a tendency to find and call attention to errors and flaws | examples=a critical attitude
2. sense_key=critical%3:00:04:: | definition=at or of a point at which a property or phenomenon suffers an abrupt change especially having enough mass to sustain a chain reaction | examples=a critical temperature of water is 100 degrees C--its boiling point at standard atmospheric pressure; critical mass
3. sense_key=critical%3:00:02:: | definition=characterized by careful evaluation and judgment | examples=a critical reading; a critical dissertation
4. sense_key=critical%5:00:00:indispensable:00 | definition=urgently needed; absolutely necessary | synonyms=vital | examples=a critical element of the plan; critical medical supplies
5. sense_key=critical%5:00:00:crucial:00 | definition=forming or having the nature of a turning point or crisis | synonyms=decisive | examples=a critical point in the campaign; the critical test
6. sense_key=critical%3:00:03:: | definition=being in or verging on a state of crisis or emergency | examples=a critical shortage of food; a critical illness
7. sense_key=critical%3:01:00:: | definition=of or involving or characteristic of critics or criticism | examples=critical acclaim

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

finish_reason: stop

role: assistant

reasoning_content: We need answer JSON only. Need decide sense. Context: "whose loss had a critical role in setting off the cancer" meaning essential, decisive? Target critical modifying role. Gene loss had a critical role in setting off cancer = crucial/important, absolutely necessary? Candidate 4 indispensable: urgently needed; absolutely necessary; examples critical element of plan; critical medical supplies. Candidate 5 crucial: forming or having nature of turning point or crisis; decisive; examples critical point in campaign; critical test. Phrase "critical role in setting off" means played an essential/decisive causal role. WordNet often maps "critical" as indispensable sense for "a critical role"? Need choose single best. Sense 4 synonyms vital, definition urgently needed absolutely necessary. Role itself isn't urgently needed, but gene loss was necessary in causation? Sense 5 decisive turning point: loss had a decisive role in triggering cancer. The examples sense 5: critical point/test; context "setting off" cancer, turning point from normal to cancer. Could be sense 5. Need infer WSD likely. In biomedical text "critical role" commonly means essential/indispensable (vital). Sense 4 definition "urgently needed; absolutely necessary" synonyms vital; examples "a critical element of the plan". "critical role" aligns with essential/vital role. Sense 5 is more temporal/crisis turning point, not role. So choose 4. Need output JSON only with sense_index 4. Ensure no extra.

format: unknown

native_finish_reason: stop

provider: Moonshot AI

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: role
Target surface form: role
Context:
But there was no way to prove Dr. Knudson's "two-hit "theory. Back then, scientists had no way of ferreting out specific genes, but under a microscope they could see the 23 pairs of chromosomes in the cells that contain the genes. Occasionally, gross chromosome damage was visible. Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical <t>role</t> in setting off the cancer. But he did not know which gene or genes had disappeared.

Candidate senses:
1. sense_key=role%1:04:00:: | definition=the actions and activities assigned to or required or expected of a person or group | synonyms=function, office, part | examples=the function of a teacher; the government must do its part
2. sense_key=role%1:09:00:: | definition=an actor's portrayal of someone in a play | synonyms=character, theatrical role, part, persona | examples=she played the part of Desdemona
3. sense_key=role%1:07:00:: | definition=what something is used for | synonyms=function, purpose, use | examples=the function of an auger is to bore holes; ballet is beautiful but what use is it?
4. sense_key=role%1:04:01:: | definition=normal or customary activity of a person in a particular social setting | examples=what is your role on the team?

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The target word "role" in context: "a gene or genes whose loss had a critical role in setting off the cancer." Here role refers to the function/purpose of the gene loss in causing cancer. Sense 3 "what something is used for" function/purpose seems closest? Actually "critical role in setting off the cancer" means critical function/part played in causing cancer. Among candidates: sense 1 actions/activities assigned to person/group (not fit, genes not persons). Sense 3 function/purpose of something. Sense 4 customary activity of person in social setting (not fit). Best is 3. Need return only JSON. No sense key. Ensure exactly {"sense_index": 3}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: set_off
Target surface form: setting off
Context:
But there was no way to prove Dr. Knudson's "two-hit "theory. Back then, scientists had no way of ferreting out specific genes, but under a microscope they could see the 23 pairs of chromosomes in the cells that contain the genes. Occasionally, gross chromosome damage was visible. Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in <t>setting off</t> the cancer. But he did not know which gene or genes had disappeared.

Candidate senses:
1. sense_key=set_off%2:36:00:: | definition=put in motion or move to act | synonyms=trip, actuate, trigger, activate, spark off, spark | examples=trigger a reaction; actuate the circuits
2. sense_key=set_off%2:38:00:: | definition=leave | synonyms=depart, part, start, start out, set forth, set out | examples=The family took off for Florida
3. sense_key=set_off%2:30:02:: | definition=direct attention to, as if by means of contrast | synonyms=bring out | examples=This dress accentuates your nice figure!; I set off these words by brackets
4. sense_key=set_off%2:30:00:: | definition=cause to burst with a violent release of energy | synonyms=explode, detonate, blow up | examples=We exploded the nuclear bomb
5. sense_key=set_off%2:42:00:: | definition=make up for | synonyms=cancel, offset | examples=His skills offset his opponent's superior strength
6. sense_key=set_off%2:30:01:: | definition=set in motion or cause to begin | examples=The guide set the tour off to a good start
7. sense_key=set_off%2:32:00:: | definition=provoke or stir up | synonyms=incite, instigate, stir up | examples=incite a riot; set off great unrest among the people

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context: "whose loss had a critical role in setting off the cancer." Meaning initiating/triggering the cancer. Sense 1: put in motion or move to act, trigger, activate. Sense 6: set in motion or cause to begin (The guide set the tour off to a good start). "Setting off the cancer" = triggering/initiating the cancer process. Best is sense 1 (trigger a reaction). Return {"sense_index": 1}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
But there was no way to prove Dr. Knudson's "two-hit "theory. Back then, scientists had no way of ferreting out specific genes, but under a microscope they could see the 23 pairs of chromosomes in the cells that contain the genes. Occasionally, gross chromosome damage was visible. Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the <t>cancer</t>. But he did not know which gene or genes had disappeared.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context is clearly medical: eye cancer, tumor suppressor gene loss setting off cancer. Best sense is 1 malignant growth/tumor. Need return only JSON object. Ensure no extra text. Final only JSON.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: know
Target surface form: know
Context:
Back then, scientists had no way of ferreting out specific genes, but under a microscope they could see the 23 pairs of chromosomes in the cells that contain the genes. Occasionally, gross chromosome damage was visible. Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not <t>know</t> which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer.

Candidate senses:
1. sense_key=know%2:31:01:: | definition=be cognizant or aware of a fact or a specific piece of information; possess knowledge or information about | synonyms=cognize, cognise | examples=I know that the President lied to the people; I want to know who is winning the game!
2. sense_key=know%2:31:03:: | definition=know how to do or perform something | examples=She knows how to knit; Does your husband know how to cook?
3. sense_key=know%2:31:02:: | definition=be aware of the truth of something; have a belief or faith in something; regard as true beyond any doubt | examples=I know that I left the key on the table; Galileo knew that the earth moves around the sun
4. sense_key=know%2:31:00:: | definition=be familiar or acquainted with a person or an object | examples=She doesn't know this composer; Do you know my sister?
5. sense_key=know%2:31:04:: | definition=have firsthand knowledge of states, situations, emotions, or sensations | synonyms=experience, live | examples=I know the feeling!; have you ever known hunger?
6. sense_key=know%2:31:06:: | definition=accept (someone) to be what is claimed or accept his power and authority | synonyms=acknowledge, recognize, recognise | examples=The Crown Prince was acknowledged as the true heir to the throne; We do not recognize your gods
7. sense_key=know%2:31:15:: | definition=have fixed in the mind | examples=I know Latin; This student knows her irregular verbs
8. sense_key=know%2:35:00:: | definition=have sexual intercourse with | synonyms=sleep together, roll in the hay, love, make out, make love, sleep with | examples=This student sleeps with everyone in her dorm; Adam knew Eve
9. sense_key=know%2:31:11:: | definition=know the nature or character of | examples=we all knew her as a big show-off
10. sense_key=know%2:31:12:: | definition=be able to distinguish, recognize as being different | examples=The child knows right from wrong
11. sense_key=know%2:31:14:: | definition=perceive as familiar | examples=I know this voice!

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to disambiguate "know" in context: "But he did not know which gene or genes had disappeared."

The context is about Dr. Knudson not possessing specific information about which gene(s) had disappeared. This is about being cognizant/aware of a specific piece of information.

Sense 1: be cognizant or aware of a fact or a specific piece of information; possess knowledge or information about. Examples: "I want to know who is winning the game!" - this matches "did not know which gene or genes had disappeared" - an embedded wh-question, specific piece of information.

Sense 3: be aware of the truth of something; have belief/faith. Examples use "know that..." clauses about truth.

The sentence uses "know which gene or genes had disappeared" - an indirect question, seeking specific information. This aligns best with sense 1 (possess knowledge or information about, aware of specific piece of information). Example "I want to know who is winning the game" is very parallel with wh-complement.

So answer sense_index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: then
Target surface form: Then
Context:
Occasionally, gross chromosome damage was visible. Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. <t>Then</t>, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team used a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a cell.

Candidate senses:
1. sense_key=then%4:02:00:: | definition=subsequently or soon afterward (often used as sentence connectors) | synonyms=so, and so, and then | examples=then he left; go left first, then right
2. sense_key=then%4:02:02:: | definition=in that case or as a consequence | examples=if he didn't take it, then who did?; keep it then if you want to
3. sense_key=then%4:02:01:: | definition=at that time | examples=I was young then; prices were lower back then

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to disambiguate the word "Then" in the context. Let me analyze.

The context: "But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee... found the answer."

Here "Then" is used as a sentence connector meaning "subsequently" or "after that" - it indicates what happened next in the sequence of events. Dr. Knudson didn't know which gene, and then/subsequently a team found the answer.

Sense 1: subsequently or soon afterward (often used as sentence connectors) - "then he left" - this fits perfectly. It's a sentence connector indicating sequence.

Sense 2: in that case or as a consequence - conditional/consequential, doesn't fit.

Sense 3: at that time - refers to a specific time in the past, "I was young then". Doesn't fit because here "then" starts a sentence and connects events narratively, meaning "next/subsequently".

Note: within the same sentence there's "then at the University of Utah" which is sense 3 (at that time), but the target is the sentence-initial "<t>Then</t>" which is the connector.

Answer: sense_index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: scientific
Target surface form: scientific
Context:
Occasionally, gross chromosome damage was visible. Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a <t>scientific</t> team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team used a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a cell.

Candidate senses:
1. sense_key=scientific%3:01:00:: | definition=of or relating to the practice of science | examples=scientific journals
2. sense_key=scientific%3:00:00:: | definition=conforming with the principles or methods used in science | examples=a scientific approach

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer JSON only. Need choose best sense. Target 'scientific team' led by molecular geneticist. Sense 1 of or relating to practice of science, examples scientific journals. Sense 2 conforming with principles/methods used in science, scientific approach. 'scientific team' means team of scientists / relating to science practice, not methodologically scientific. So sense_index 1. Ensure final only JSON.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: team
Target surface form: team
Context:
Occasionally, gross chromosome damage was visible. Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific <t>team</t> led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team used a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a cell.

Candidate senses:
1. sense_key=team%1:14:00:: | definition=a cooperative unit (especially in sports) | synonyms=squad
2. sense_key=team%1:14:01:: | definition=two or more draft animals that work together to pull something

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The target is "team" in "a scientific team led by molecular geneticist Webster Cavenee". This refers to a group of people working cooperatively. Candidate 1: a cooperative unit (especially in sports) — best fit for scientific team. Candidate 2: draft animals — irrelevant. Return JSON with sense_index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: lead
Target surface form: led
Context:
Occasionally, gross chromosome damage was visible. Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team <t>led</t> by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team used a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a cell.

Candidate senses:
1. sense_key=lead%2:38:01:: | definition=take somebody somewhere | synonyms=take, direct, conduct, guide | examples=We lead him to our chief; can you take me to the main entrance?
2. sense_key=lead%2:42:04:: | definition=have as a result or residue | synonyms=leave, result | examples=The water left a mark on the silk dress; Her blood left a stain on the napkin
3. sense_key=lead%2:42:12:: | definition=tend to or result in | examples=This remark lead to further arguments among the guests
4. sense_key=lead%2:38:00:: | definition=travel in front of; go in advance of others | synonyms=head | examples=The procession was headed by John
5. sense_key=lead%2:32:00:: | definition=cause to undertake a certain action | examples=Her greed led her to forge the checks
6. sense_key=lead%2:42:00:: | definition=stretch out over a distance, space, time, or scope; run or extend between two points or beyond a certain point | synonyms=run, go, pass, extend | examples=Service runs all the way to Cranbury; His knowledge doesn't go very far
7. sense_key=lead%2:41:00:: | definition=be in charge of | synonyms=head | examples=Who is heading this project?
8. sense_key=lead%2:42:01:: | definition=be ahead of others; be the first | synonyms=top | examples=she topped her class every year
9. sense_key=lead%2:41:12:: | definition=be conducive to | synonyms=contribute, conduce | examples=The use of computers in the classroom lead to better writing
10. sense_key=lead%2:36:00:: | definition=lead, as in the performance of a composition | synonyms=conduct, direct | examples=conduct an orchestra; Barenboim conducted the Chicago symphony for years
11. sense_key=lead%2:42:03:: | definition=lead, extend, or afford access | synonyms=go | examples=This door goes to the basement; The road runs South
12. sense_key=lead%2:38:02:: | definition=move ahead (of others) in time or space | synonyms=precede
13. sense_key=lead%2:42:02:: | definition=cause something to pass or lead somewhere | synonyms=run | examples=Run the wire behind the cabinet
14. sense_key=lead%2:32:01:: | definition=preside over | synonyms=moderate, chair | examples=John moderated the discussion

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The target word is "led" in "a scientific team led by molecular geneticist Webster Cavenee". This means the team was headed/in charge of by Webster Cavenee. Sense 7 "be in charge of" with synonym head, example "Who is heading this project?" fits. Passive "team led by X" = X headed the team. So sense_index 7.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: then
Target surface form: then
Context:
Occasionally, gross chromosome damage was visible. Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, <t>then</t> at the University of Utah, found the answer. The team used a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a cell.

Candidate senses:
1. sense_key=then%4:02:00:: | definition=subsequently or soon afterward (often used as sentence connectors) | synonyms=so, and so, and then | examples=then he left; go left first, then right
2. sense_key=then%4:02:02:: | definition=in that case or as a consequence | examples=if he didn't take it, then who did?; keep it then if you want to
3. sense_key=then%4:02:01:: | definition=at that time | examples=I was young then; prices were lower back then

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The user wants WSD for "then" in context: "a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer." Here "then at the University of Utah" means at that time he was at University of Utah. So sense 3 "at that time". Need return only JSON {"sense_index": 3}. Ensure no extra text.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: find
Target surface form: found
Context:
Occasionally, gross chromosome damage was visible. Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, <t>found</t> the answer. The team used a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a cell.

Candidate senses:
1. sense_key=find%2:40:02:: | definition=come upon, as if by accident; meet with | synonyms=happen, chance, bump, encounter | examples=We find this idea in Plato; I happened upon the most wonderful bakery not very far from here
2. sense_key=find%2:39:02:: | definition=discover or determine the existence, presence, or fact of | synonyms=detect, observe, discover, notice | examples=She detected high levels of lead in her drinking water; We found traces of lead in the paint
3. sense_key=find%2:40:00:: | definition=come upon after searching; find the location of something that was missed or lost | synonyms=regain | examples=Did you find your glasses?; I cannot find my gloves!
4. sense_key=find%2:32:00:: | definition=establish after a calculation, investigation, experiment, survey, or study | synonyms=determine, find out, ascertain | examples=find the product of two numbers; The physicist who found the elusive particle won the Nobel Prize
5. sense_key=find%2:31:10:: | definition=come to believe on the basis of emotion, intuitions, or indefinite grounds | synonyms=feel | examples=I feel that he doesn't like me; I find him to be obnoxious
6. sense_key=find%2:39:01:: | definition=perceive or be contemporaneous with | synonyms=witness, see | examples=We found Republicans winning the offices; You'll see a lot of cheating in this school
7. sense_key=find%2:40:01:: | definition=get something or somebody for a specific purpose | synonyms=line up, get hold, come up | examples=I found this gadget that will serve as a bottle opener; I got hold of these tools to fix our plumbing
8. sense_key=find%2:36:00:: | definition=make a discovery, make a new finding | synonyms=discover | examples=Roentgen discovered X-rays; Physicists believe they found a new elementary particle
9. sense_key=find%2:31:09:: | definition=make a discovery | synonyms=discover | examples=She found that he had lied to her; The story is false, so far as I can discover
10. sense_key=find%2:40:03:: | definition=obtain through effort or management | examples=She found the time and energy to take care of her aging parents; We found the money to send our sons to college
11. sense_key=find%2:32:01:: | definition=decide on and make a declaration about | synonyms=rule | examples=find someone guilty
12. sense_key=find%2:30:00:: | definition=receive a specified treatment (abstract) | synonyms=receive, get, obtain, incur | examples=These aspects of civilization do not find expression or receive an interpretation; His movie received a good review
13. sense_key=find%2:39:05:: | definition=perceive oneself to be in a certain condition or place | examples=I found myself in a difficult situation; When he woke up, he found himself in a hospital room
14. sense_key=find%2:40:15:: | definition=get or find back; recover the use of | synonyms=recover, retrieve, regain | examples=She regained control of herself; She found her voice and replied quickly
15. sense_key=find%2:38:10:: | definition=succeed in reaching; arrive at | examples=The arrow found its mark
16. sense_key=find%2:30:13:: | definition=accept and make use of one's personality, abilities, and situation | synonyms=find oneself | examples=My son went to Berkeley to find himself

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer only JSON. Need determine sense. Context: scientific team ... found the answer. Means established/determined after investigation? Candidates: 4 establish after calculation/investigation/study (determine, find out, ascertain). 8 make a discovery/new finding. The phrase "found the answer" to which gene had disappeared, via scientific team using probes. Best: establish after investigation, determine/find out/ascertain = sense 4. Need output exactly JSON no extra. Ensure sense_index 4. No markdown. Done.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: answer
Target surface form: answer
Context:
Occasionally, gross chromosome damage was visible. Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the <t>answer</t>. The team used a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a cell.

Candidate senses:
1. sense_key=answer%1:10:01:: | definition=a statement (either spoken or written) that is made to reply to a question or request or criticism or accusation | synonyms=reply, response | examples=I waited several days for his answer; he wrote replies to several of his critics
2. sense_key=answer%1:10:02:: | definition=a statement that solves a problem or explains how to solve the problem | synonyms=solution, result, resolution, solvent | examples=they were trying to find a peaceful solution; the answers were in the back of the book
3. sense_key=answer%1:10:00:: | definition=the speech act of replying to a question
4. sense_key=answer%1:10:03:: | definition=the principal pleading by the defendant in response to plaintiff's complaint; in criminal law it consists of the defendant's plea of `guilty' or `not guilty' (or nolo contendere); in civil law it must contain denials of all allegations in the plaintiff's complaint that the defendant hopes to controvert and it can contain affirmative defenses or counterclaims
5. sense_key=answer%1:04:00:: | definition=a nonverbal reaction | examples=his answer to any problem was to get drunk; their answer was to sue me

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context: Dr. Knudson did not know which gene had disappeared. Then Cavenee's team "found the answer" using gene probes. This is finding the solution to a problem/question, not replying to a question. Best sense is 2: a statement that solves a problem or explains how to solve the problem; synonyms solution, result, resolution. Need return JSON only.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: team
Target surface form: team
Context:
Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The <t>team</t> used a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a cell. By analyzing cells extracted from eye tumors, they found defects in the second copy of chromosome 13 in the exact area as in the first copy of the chromosome.

Candidate senses:
1. sense_key=team%1:14:00:: | definition=a cooperative unit (especially in sports) | synonyms=squad
2. sense_key=team%1:14:01:: | definition=two or more draft animals that work together to pull something

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context is about a scientific team led by a molecular geneticist. "Team" here refers to a cooperative unit of people working together, not draft animals. Sense 1 is "a cooperative unit (especially in sports)". Although especially sports, the broader cooperative unit fits scientific team. Sense 2 is draft animals, clearly wrong. Return JSON only.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: used
Context:
Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team <t>used</t> a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a cell. By analyzing cells extracted from eye tumors, they found defects in the second copy of chromosome 13 in the exact area as in the first copy of the chromosome.

Candidate senses:
1. sense_key=use%2:34:01:: | definition=put into service; make work or employ for a particular purpose or for its inherent or natural purpose | synonyms=utilize, utilise, apply, employ | examples=use your head!; we only use Spanish at home
2. sense_key=use%2:34:02:: | definition=take or consume (regularly or habitually) | synonyms=habituate | examples=She uses drugs rarely
3. sense_key=use%2:34:00:: | definition=use up, consume fully | synonyms=expend | examples=The legislature expended its time on school questions
4. sense_key=use%2:41:14:: | definition=seek or achieve an end by using to one's advantage | examples=She uses her influential friends to get jobs; The president's wife used her good connections
5. sense_key=use%2:41:04:: | definition=avail oneself to | synonyms=practice, apply | examples=apply a principle; practice a religion
6. sense_key=use%2:41:03:: | definition=habitually do something (use only in the past tense) | examples=She used to call her mother every week but now she calls only occasionally; I used to get sick when I ate in that dining hall

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context: "The team used a battery of the newly developed gene probes" - they employed/utilized the gene probes for a particular purpose (to track genes). This is clearly sense 1: put into service; make work or employ for a particular purpose. Not consuming, not exploiting people, not habitually, not "used to". Answer {"sense_index": 1}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: battery
Target surface form: battery
Context:
Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team used a <t>battery</t> of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a cell. By analyzing cells extracted from eye tumors, they found defects in the second copy of chromosome 13 in the exact area as in the first copy of the chromosome.

Candidate senses:
1. sense_key=battery%1:14:02:: | definition=group of guns or missile launchers operated together at one place
2. sense_key=battery%1:06:00:: | definition=a device that produces electricity; may have several primary or secondary cells arranged in parallel or series | synonyms=electric battery
3. sense_key=battery%1:14:01:: | definition=a collection of related things intended for use together | examples=took a battery of achievement tests
4. sense_key=battery%1:14:03:: | definition=a unit composed of the pitcher and catcher
5. sense_key=battery%1:06:03:: | definition=a series of stamps operated in one mortar for crushing ores | synonyms=stamp battery
6. sense_key=battery%1:04:01:: | definition=the heavy fire of artillery to saturate an area rather than hit a specific target | synonyms=barrage, barrage fire, bombardment, shelling | examples=they laid down a barrage in front of the advancing troops; the shelling went on for hours without pausing
7. sense_key=battery%1:04:00:: | definition=an assault in which the assailant makes physical contact | synonyms=assault and battery

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context is "a battery of the newly developed gene probes". This is a collection/set of related tools used together. Sense 3: a collection of related things intended for use together, example "took a battery of achievement tests". That fits best: a battery of tests/probes. Need output only JSON {"sense_index": 3}. Ensure no extra text.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: develop
Target surface form: developed
Context:
Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team used a battery of the newly <t>developed</t> "gene probes, "snippets of genetic material that can track a gene's presence in a cell. By analyzing cells extracted from eye tumors, they found defects in the second copy of chromosome 13 in the exact area as in the first copy of the chromosome.

Candidate senses:
1. sense_key=develop%2:36:01:: | definition=make something new, such as a product or a mental or artistic creation | examples=Her company developed a new kind of building material that withstands all kinds of weather; They developed a new technique
2. sense_key=develop%2:36:00:: | definition=work out | synonyms=evolve, germinate | examples=We have developed a new theory of evolution
3. sense_key=develop%2:30:06:: | definition=gain through experience | synonyms=acquire, evolve | examples=I acquired a strong aversion to television; Children must develop a sense of right and wrong
4. sense_key=develop%2:29:00:: | definition=come to have or undergo a change of (physical features and attributes) | synonyms=grow, produce, get, acquire | examples=He grew a beard; The patient developed abdominal pains
5. sense_key=develop%2:42:00:: | definition=come into existence; take on form or shape | synonyms=originate, arise, rise, uprise, spring up, grow | examples=A new religious movement originated in that country; a love that sprang up from friendship
6. sense_key=develop%2:30:04:: | definition=change the use of and make available or usable | synonyms=build up | examples=develop land; The country developed its natural resources
7. sense_key=develop%2:32:00:: | definition=elaborate, as of theories and hypotheses | synonyms=explicate, formulate | examples=Could you develop the ideas in your thesis
8. sense_key=develop%2:31:00:: | definition=create by training and teaching | synonyms=train, prepare, educate | examples=The old master is training world-class violinists; we develop the leaders for the future
9. sense_key=develop%2:30:05:: | definition=be gradually disclosed or unfolded; become manifest | examples=The plot developed slowly
10. sense_key=develop%2:30:00:: | definition=grow, progress, unfold, or evolve through a process of evolution, natural growth, differentiation, or a conducive environment | examples=A flower developed on the branch; The country developed into a mighty superpower
11. sense_key=develop%2:30:09:: | definition=become technologically advanced | synonyms=modernize, modernise | examples=Many countries in Asia are now developing at a very fast pace; Viet Nam is modernizing rapidly
12. sense_key=develop%2:30:01:: | definition=cause to grow and differentiate in ways conforming to its natural development | synonyms=make grow | examples=The perfect climate here develops the grain; He developed a new kind of apple
13. sense_key=develop%2:36:09:: | definition=generate gradually | examples=We must develop more potential customers; develop a market for the new mobile phone
14. sense_key=develop%2:30:10:: | definition=grow emotionally or mature | synonyms=grow | examples=The child developed beautifully in her new kindergarten; When he spent a summer at camp, the boy grew noticeably and no longer showed some of his old adolescent behavior
15. sense_key=develop%2:39:00:: | definition=make visible by means of chemical solutions | examples=Please develop this roll of film for me
16. sense_key=develop%2:35:04:: | definition=superimpose a three-dimensional surface on a plane without stretching, in geometry
17. sense_key=develop%2:33:03:: | definition=move one's pieces into strategically more advantageous positions | examples=Spassky developed quickly
18. sense_key=develop%2:33:02:: | definition=move into a strategically more advantageous position | examples=develop the rook
19. sense_key=develop%2:30:13:: | definition=elaborate by the unfolding of a musical idea and by the working out of the rhythmic and harmonic changes in the theme | examples=develop the melody and change the key
20. sense_key=develop%2:30:03:: | definition=happen | synonyms=break, recrudesce | examples=Report the news as it develops; These political movements recrudesce from time to time
21. sense_key=develop%2:30:12:: | definition=expand in the form of a series | examples=Develop the function in the following form

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer only JSON. Need choose best sense for developed in context: "newly developed 'gene probes,' snippets of genetic material that can track a gene's presence in a cell." Here gene probes are a product/technique newly made/invented by science. Best sense 1: make something new, such as a product or mental/artistic creation; examples developed new technique/material. Not sense 2 work out theory (abstract), not 12 cause to grow/differentiate (apple breed) maybe "developed a new kind of apple" but probes are manufactured tools, sense 1. Need return JSON only with index. Ensure no extra.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: genetic
Target surface form: genetic
Context:
Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team used a battery of the newly developed "gene probes, "snippets of <t>genetic</t> material that can track a gene's presence in a cell. By analyzing cells extracted from eye tumors, they found defects in the second copy of chromosome 13 in the exact area as in the first copy of the chromosome.

Candidate senses:
1. sense_key=genetic%5:00:00:inheritable:00 | definition=occurring among members of a family usually by heredity | synonyms=familial, hereditary, inherited, transmitted, transmissible | examples=an inherited disease; familial traits
2. sense_key=genetic%3:01:02:: | definition=of or relating to or produced by or being a gene | synonyms=genic, genetical | examples=genic combinations; genetic code
3. sense_key=genetic%3:01:01:: | definition=pertaining to or referring to origin | examples=genetic history reconstructs the origins of a literary work
4. sense_key=genetic%3:01:00:: | definition=of or relating to the science of genetics | synonyms=genetical | examples=genetic research

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to do word sense disambiguation for "genetic" in the phrase "genetic material".

Context: "snippets of genetic material that can track a gene's presence in a cell"

The phrase "genetic material" refers to DNA/genes - material of or relating to genes.

Sense 1: occurring among family members by heredity - like inherited disease. Not quite - "genetic material" isn't about familial occurrence.
Sense 2: of or relating to or produced by or being a gene - synonyms genic, examples "genetic code". "Genetic material" = material relating to genes/DNA. This fits best.
Sense 3: pertaining to origin - not relevant.
Sense 4: of or relating to science of genetics - "genetic research" but "genetic material" is not about the science.

The best is sense 2. "genetic material" is analogous to "genetic code" - relating to genes.

Return {"sense_index": 2}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: material
Target surface form: material
Context:
Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team used a battery of the newly developed "gene probes, "snippets of genetic <t>material</t> that can track a gene's presence in a cell. By analyzing cells extracted from eye tumors, they found defects in the second copy of chromosome 13 in the exact area as in the first copy of the chromosome.

Candidate senses:
1. sense_key=material%1:27:00:: | definition=the tangible substance that goes into the makeup of a physical object | synonyms=stuff | examples=coal is a hard black material; wheat is the stuff they use to make bread
2. sense_key=material%1:10:00:: | definition=information (data or ideas or observations) that can be used or reworked into a finished form | examples=the archives provided rich material for a definitive biography
3. sense_key=material%1:06:00:: | definition=artifact made by weaving or felting or knitting or crocheting natural or synthetic fibers | synonyms=fabric, cloth, textile | examples=the fabric in the curtains was light and semitransparent; woven cloth originated in Mesopotamia around 5000 BC
4. sense_key=material%1:06:01:: | definition=things needed for doing or making something | examples=writing materials; useful teaching materials
5. sense_key=material%1:18:00:: | definition=a person judged suitable for admission or employment | examples=he was university material; she was vice-presidential material

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context: "snippets of genetic material that can track a gene's presence in a cell." Genetic material = DNA, tangible substance that makes up physical objects (chromosomes/genes). Sense 1: tangible substance that goes into makeup of physical object. This fits genetic material (DNA substance). Not information (though genetic material carries information, here snippets are physical probes). Answer index 1. Need JSON only. Ensure no sense key. final exactly {"sense_index": 1}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: presence
Target surface form: presence
Context:
Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team used a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's <t>presence</t> in a cell. By analyzing cells extracted from eye tumors, they found defects in the second copy of chromosome 13 in the exact area as in the first copy of the chromosome.

Candidate senses:
1. sense_key=presence%1:26:00:: | definition=the state of being present; current existence | examples=he tested for the presence of radon
2. sense_key=presence%1:15:00:: | definition=the immediate proximity of someone or something | synonyms=front | examples=she blushed in his presence; he sensed the presence of danger
3. sense_key=presence%1:18:00:: | definition=an invisible spiritual being felt to be nearby
4. sense_key=presence%1:09:00:: | definition=the impression that something is present | examples=he felt the presence of an evil force
5. sense_key=presence%1:07:00:: | definition=dignified manner or conduct | synonyms=bearing, comportment, mien
6. sense_key=presence%1:04:00:: | definition=the act of being present

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context: gene probes track a gene's presence in a cell. This is about whether the gene exists/is present in the cell. Sense 1: the state of being present; current existence, example "he tested for the presence of radon" — very parallel. Sense 6 "act of being present" is more about attendance. Best is sense 1. Return JSON only.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cell
Context:
Dr. Knudson found that some children with the eye cancer had inherited a damaged copy of chromosome No. 13 from a parent who had had the disease. Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team used a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a <t>cell</t>. By analyzing cells extracted from eye tumors, they found defects in the second copy of chromosome 13 in the exact area as in the first copy of the chromosome.

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context is about biology, genetics, chromosome, genes, eye tumors. "track a gene's presence in a cell" clearly refers to biological cell. Candidate sense 2. Need return only JSON object. Ensure no extra text. Final exactly {"sense_index": 2}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: analyze
Target surface form: analyzing
Context:
Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team used a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a cell. By <t>analyzing</t> cells extracted from eye tumors, they found defects in the second copy of chromosome 13 in the exact area as in the first copy of the chromosome. The finding riveted medicine.

Candidate senses:
1. sense_key=analyze%2:31:00:: | definition=consider in detail and subject to an analysis in order to discover essential features or meaning | synonyms=analyse, study, examine, canvass, canvas | examples=analyze a sonnet by Shakespeare; analyze the evidence in a criminal trial
2. sense_key=analyze%2:31:01:: | definition=make a mathematical, chemical, or grammatical analysis of; break down into components or essential features | synonyms=analyse, break down, dissect, take apart | examples=analyze a specimen; analyze a sentence
3. sense_key=analyze%2:31:04:: | definition=break down into components or essential features | synonyms=analyse | examples=analyze today's financial market
4. sense_key=analyze%2:31:03:: | definition=subject to psychoanalytic treatment | synonyms=analyse, psychoanalyze, psychoanalyse | examples=I was analyzed in Vienna by a famous psychiatrist

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context: "By analyzing cells extracted from eye tumors, they found defects in the second copy of chromosome 13..." This is scientific examination of cells to discover features/defects. Sense 1 is consider in detail/subject to analysis to discover essential features (study/examine evidence). Sense 2 is mathematical/chemical/grammatical analysis; break down into components, analyze a specimen. Cells extracted from tumors are biological specimens; analyzing cells in lab likely sense 2? Need choose best.

WordNet distinctions are subtle. analyze%2:31:00 is broad: consider in detail and subject to analysis to discover essential features/meaning; examples analyze evidence, sonnet. analyze%2:31:01: make a mathematical, chemical, or grammatical analysis of; break down into components; examples analyze a specimen; analyze a sentence. Context "cells extracted from eye tumors" = specimens; using gene probes to track gene presence; found defects. This is a biochemical/genetic analysis of cells, breaking down chromosome components. Likely sense 2 due to 'analyze a specimen' example and chemical analysis. Sense 1 also possible as examining cells to discover features. But target collocation "analyzing cells extracted" scientific lab specimen aligns strongly with sense 2 example "analyze a specimen" and chemical analysis. Need answer only JSON {"sense_index": 2}. Ensure no extra.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cells
Context:
Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team used a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a cell. By analyzing <t>cells</t> extracted from eye tumors, they found defects in the second copy of chromosome 13 in the exact area as in the first copy of the chromosome. The finding riveted medicine.

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to identify the correct sense of "cells" in the given context. The context is about biology, genetics, cancer, chromosomes, genes, eye tumors. "cells extracted from eye tumors" clearly refers to biological cells - the basic structural and functional unit of organisms.

The answer is sense index 2: (biology) the basic structural and functional unit of all organisms.

I need to return only a JSON object like {"sense_index": 2}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: extract
Target surface form: extracted
Context:
Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team used a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a cell. By analyzing cells <t>extracted</t> from eye tumors, they found defects in the second copy of chromosome 13 in the exact area as in the first copy of the chromosome. The finding riveted medicine.

Candidate senses:
1. sense_key=extract%2:35:04:: | definition=remove, usually with some force or effort; also used in an abstract sense | synonyms=pull out, pull, pull up, take out, draw out | examples=pull weeds; extract a bad tooth
2. sense_key=extract%2:40:00:: | definition=get despite difficulties or obstacles | examples=I extracted a promise from the Dean for two new positions
3. sense_key=extract%2:36:00:: | definition=deduce (a principle) or construe (a meaning) | synonyms=educe, evoke, elicit, draw out | examples=We drew out some interesting linguistic data from the native informant
4. sense_key=extract%2:30:00:: | definition=extract by the process of distillation | synonyms=distill, distil | examples=distill the essence of this compound
5. sense_key=extract%2:35:07:: | definition=separate (a metal) from an ore
6. sense_key=extract%2:35:05:: | definition=obtain from a substance, as by mechanical action | synonyms=press out, express | examples=Italians express coffee rather than filter it
7. sense_key=extract%2:31:00:: | definition=take out of a literary work in order to cite or copy | synonyms=excerpt, take out
8. sense_key=extract%2:31:02:: | definition=calculate the root of a number

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer only JSON. Need determine sense of 'extracted' in context: 'analyzing cells extracted from eye tumors' means cells removed/taken out from tumors, likely physically removed from tissue. Candidate senses: 1 remove usually with force/effort; synonyms pull out, take out, draw out; examples pull weeds, extract a bad tooth. In biomedical context 'cells extracted from eye tumors' = taken out/removed from tumors (maybe obtained by biopsy). Sense 6 obtain from a substance as by mechanical action (press out/express) not exact; sense 1 best. Need final only JSON {"sense_index": 1}. Ensure no extra. Done.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: eye
Target surface form: eye
Context:
Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team used a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a cell. By analyzing cells extracted from <t>eye</t> tumors, they found defects in the second copy of chromosome 13 in the exact area as in the first copy of the chromosome. The finding riveted medicine.

Candidate senses:
1. sense_key=eye%1:08:00:: | definition=the organ of sight | synonyms=oculus, optic
2. sense_key=eye%1:09:00:: | definition=good discernment (either visually or as if visually) | examples=she has an eye for fresh talent; he has an artist's eye
3. sense_key=eye%1:09:01:: | definition=attention to what is seen | examples=he tried to catch her eye
4. sense_key=eye%1:15:00:: | definition=an area that is approximately central within some larger region | synonyms=center, centre, middle, heart | examples=it is in the center of town; they ran forward into the heart of the struggle
5. sense_key=eye%1:06:00:: | definition=a small hole or loop (as in a needle) | examples=the thread wouldn't go through the eye

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user is asking for word sense disambiguation of "eye" in the context of "eye tumors". The context is medical/scientific about chromosome 13, retinoblastoma likely. "cells extracted from eye tumors" - here eye refers to the organ of sight. Sense 1 is "the organ of sight". The answer is sense_index 1.

Need to return only JSON object.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: find
Target surface form: found
Context:
Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team used a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a cell. By analyzing cells extracted from eye tumors, they <t>found</t> defects in the second copy of chromosome 13 in the exact area as in the first copy of the chromosome. The finding riveted medicine.

Candidate senses:
1. sense_key=find%2:40:02:: | definition=come upon, as if by accident; meet with | synonyms=happen, chance, bump, encounter | examples=We find this idea in Plato; I happened upon the most wonderful bakery not very far from here
2. sense_key=find%2:39:02:: | definition=discover or determine the existence, presence, or fact of | synonyms=detect, observe, discover, notice | examples=She detected high levels of lead in her drinking water; We found traces of lead in the paint
3. sense_key=find%2:40:00:: | definition=come upon after searching; find the location of something that was missed or lost | synonyms=regain | examples=Did you find your glasses?; I cannot find my gloves!
4. sense_key=find%2:32:00:: | definition=establish after a calculation, investigation, experiment, survey, or study | synonyms=determine, find out, ascertain | examples=find the product of two numbers; The physicist who found the elusive particle won the Nobel Prize
5. sense_key=find%2:31:10:: | definition=come to believe on the basis of emotion, intuitions, or indefinite grounds | synonyms=feel | examples=I feel that he doesn't like me; I find him to be obnoxious
6. sense_key=find%2:39:01:: | definition=perceive or be contemporaneous with | synonyms=witness, see | examples=We found Republicans winning the offices; You'll see a lot of cheating in this school
7. sense_key=find%2:40:01:: | definition=get something or somebody for a specific purpose | synonyms=line up, get hold, come up | examples=I found this gadget that will serve as a bottle opener; I got hold of these tools to fix our plumbing
8. sense_key=find%2:36:00:: | definition=make a discovery, make a new finding | synonyms=discover | examples=Roentgen discovered X-rays; Physicists believe they found a new elementary particle
9. sense_key=find%2:31:09:: | definition=make a discovery | synonyms=discover | examples=She found that he had lied to her; The story is false, so far as I can discover
10. sense_key=find%2:40:03:: | definition=obtain through effort or management | examples=She found the time and energy to take care of her aging parents; We found the money to send our sons to college
11. sense_key=find%2:32:01:: | definition=decide on and make a declaration about | synonyms=rule | examples=find someone guilty
12. sense_key=find%2:30:00:: | definition=receive a specified treatment (abstract) | synonyms=receive, get, obtain, incur | examples=These aspects of civilization do not find expression or receive an interpretation; His movie received a good review
13. sense_key=find%2:39:05:: | definition=perceive oneself to be in a certain condition or place | examples=I found myself in a difficult situation; When he woke up, he found himself in a hospital room
14. sense_key=find%2:40:15:: | definition=get or find back; recover the use of | synonyms=recover, retrieve, regain | examples=She regained control of herself; She found her voice and replied quickly
15. sense_key=find%2:38:10:: | definition=succeed in reaching; arrive at | examples=The arrow found its mark
16. sense_key=find%2:30:13:: | definition=accept and make use of one's personality, abilities, and situation | synonyms=find oneself | examples=My son went to Berkeley to find himself

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target sentence: "By analyzing cells extracted from eye tumors, they found defects in the second copy of chromosome 13..." This is a scientific investigation context. They discovered/determined existence/presence of defects through analysis. Candidate 2: discover or determine existence, presence, or fact of (detect, observe, discover, notice) examples: found traces of lead in paint. That fits: analyzing cells found defects. Candidate 4 establish after calculation/investigation/experiment/study (determine, find out, ascertain) examples physicist found elusive particle; find product. Also plausible because defects established by analyzing cells. Need choose best indexed sense.

WSD: "found defects" = observed/detected presence of defects, akin found traces of lead in paint. Sense 2 examples exactly "We found traces of lead in the paint" and "She detected high levels of lead". The context: by analyzing cells extracted from tumors, they found defects in chromosome. This is discovering existence/presence/fact of defects. Sense 4 is more establish after investigation, determine; could apply to "found the answer" earlier maybe. But target is "found defects" (existence/presence). Best is 2.

Need return only JSON. Ensure no extra.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: defect
Target surface form: defects
Context:
Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team used a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a cell. By analyzing cells extracted from eye tumors, they found <t>defects</t> in the second copy of chromosome 13 in the exact area as in the first copy of the chromosome. The finding riveted medicine.

Candidate senses:
1. sense_key=defect%1:26:01:: | definition=an imperfection in a bodily system | examples=visual defects; this device permits detection of defects in the lungs
2. sense_key=defect%1:07:01:: | definition=a failing or deficiency | synonyms=shortcoming | examples=that interpretation is an unfortunate defect of our lack of information
3. sense_key=defect%1:26:00:: | definition=an imperfection in an object or machine | synonyms=fault, flaw | examples=a flaw caused the crystal to shatter; if there are any defects you should send it back to the manufacturer
4. sense_key=defect%1:07:00:: | definition=a mark or flaw that spoils the appearance of something (especially on a person's body) | synonyms=blemish, mar | examples=a facial blemish

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer only JSON. Need decide WSD. Context genetic defects in chromosome copy, bodily system? Target defects found in chromosome area in eye tumors. Candidate 1 imperfection in a bodily system examples visual defects detection in lungs. 3 imperfection in object/machine fault/flaw. Chromosome is biological body system, defect in copy of chromosome = abnormality/imperfection in bodily/genetic system. Sense 1 likely. Need output JSON only. Ensure sense_index numeric. Final only {"sense_index": 1}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: second
Target surface form: second
Context:
Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team used a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a cell. By analyzing cells extracted from eye tumors, they found defects in the <t>second</t> copy of chromosome 13 in the exact area as in the first copy of the chromosome. The finding riveted medicine.

Candidate senses:
1. sense_key=second%5:00:00:ordinal:00 | definition=coming next after the first in position in space or time or degree or magnitude | synonyms=2nd, 2d
2. sense_key=second%3:00:00:: | definition=a part or voice or instrument or orchestra section lower in pitch than or subordinate to the first | examples=second flute; the second violins

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "second" in the context "the second copy of chromosome 13". This clearly means the copy coming next after the first copy - ordinal sense. The context is about two copies of chromosome 13 (humans have two copies), and they found defects in the second copy in the same area as the first copy. This is ordinal: coming next after the first in position/order.

Sense 1 is ordinal "coming next after the first in position in space or time or degree or magnitude" - fits perfectly.
Sense 2 is musical - lower in pitch/subordinate - doesn't fit.

Answer: {"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: copy
Target surface form: copy
Context:
Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team used a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a cell. By analyzing cells extracted from eye tumors, they found defects in the second <t>copy</t> of chromosome 13 in the exact area as in the first copy of the chromosome. The finding riveted medicine.

Candidate senses:
1. sense_key=copy%1:10:00:: | definition=a reproduction of a written record (e.g. of a legal or school record) | synonyms=transcript
2. sense_key=copy%1:06:00:: | definition=a thing made to be similar or identical to another thing | examples=she made a copy of the designer dress; the clone was a copy of its ancestor
3. sense_key=copy%1:10:01:: | definition=matter to be printed; exclusive of graphical materials | synonyms=written matter
4. sense_key=copy%1:10:02:: | definition=material suitable for a journalistic account | examples=catastrophes make good copy

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer WSD JSON only. Need determine sense of copy in context: "defects in the second copy of chromosome 13 ... as in the first copy" Means one of two homologous chromosomes, an instance/duplicate? Candidate senses: 1 transcript legal record, 2 thing made similar/identical to another thing, 3 matter to be printed, 4 journalistic material. Best is sense 2: a thing made to be similar or identical to another thing (each chromosome copy is a duplicate/replica/instance). Though biologically homologous chromosomes are not copies made from each other exactly, WordNet schematic sense 2 closest: thing similar/identical to another. Need return JSON exactly like {"sense_index": 2} no extra. Ensure no sense key. final only JSON.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: exact
Target surface form: exact
Context:
Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team used a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a cell. By analyzing cells extracted from eye tumors, they found defects in the second copy of chromosome 13 in the <t>exact</t> area as in the first copy of the chromosome. The finding riveted medicine.

Candidate senses:
1. sense_key=exact%3:00:00:: | definition=marked by strict and particular and complete accordance with fact | examples=an exact mind; an exact copy
2. sense_key=exact%5:00:00:correct:00 | definition=(of ideas, images, representations, expressions) characterized by perfect conformity to fact or truth ; strictly correct | synonyms=accurate, precise | examples=a precise image; a precise measurement

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word "exact" in context: "in the exact area as in the first copy of the chromosome." Here "exact" modifies "area" meaning the precise/same location. The phrase "the exact area as" means strictly correct/precise location, conformity to fact. Candidate 1: marked by strict and particular and complete accordance with fact, examples an exact mind; an exact copy. Candidate 2: of ideas/images/representations/expressions characterized by perfect conformity to fact/truth; strictly correct; synonyms accurate, precise; examples precise image/measurement.

In context, "exact area" refers to precise location, not an idea/image/representation/expression. Sense 1 is broader: strict/particular/complete accordance with fact; "exact copy". The phrase "exact same area" idiomatically means precise. Which is better? Need choose single best. WordNet likely has exact adjective senses: exact%3:00:00:: = marked by strict and particular and complete accordance with fact; exact%5:00:00:correct:00 = (of ideas, images, representations, expressions) characterized by perfect conformity to fact or truth; strictly correct. The second is restricted to ideas/images/representations/expressions; area is a physical location, so sense 1 likely. Although synonyms accurate precise could tempt, gloss restriction excludes area. Return JSON only with sense_index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: first
Target surface form: first
Context:
Under a microscope he could actually see that a bit of chromosome 13 was missing. He assumed the missing piece contained a gene or genes whose loss had a critical role in setting off the cancer. But he did not know which gene or genes had disappeared. Then, a scientific team led by molecular geneticist Webster Cavenee, then at the University of Utah, found the answer. The team used a battery of the newly developed "gene probes, "snippets of genetic material that can track a gene's presence in a cell. By analyzing cells extracted from eye tumors, they found defects in the second copy of chromosome 13 in the exact area as in the <t>first</t> copy of the chromosome. The finding riveted medicine.

Candidate senses:
1. sense_key=first%3:00:00:: | definition=preceding all others in time or space or degree | examples=the first house on the right; the first day of spring
2. sense_key=first%5:00:00:ordinal:00 | definition=indicating the beginning unit in a series | synonyms=1st
3. sense_key=first%5:00:02:opening:00 | definition=serving to set in motion | synonyms=inaugural, initiative, initiatory, maiden | examples=the magazine's inaugural issue; the initiative phase in the negotiations
4. sense_key=first%5:00:01:opening:00 | definition=serving to begin | synonyms=beginning | examples=the beginning canto of the poem; the first verse
5. sense_key=first%5:00:00:best:00 | definition=ranking above all others | synonyms=foremost, world-class | examples=was first in her class; the foremost figure among marine artists
6. sense_key=first%3:00:03:: | definition=highest in pitch or chief among parts or voices or instruments or orchestra sections | examples=first soprano; the first violin section

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer JSON only. Need determine sense. Context: "defects in the second copy of chromosome 13 in the exact area as in the first copy of the chromosome." Here first copy vs second copy of chromosome 13; ordinal in a series of two copies. Candidate 1 preceding all others in time/space/degree (adjective first%3) vs 2 ordinal indicating beginning unit in a series synonyms 1st. Need choose best indexed sense. Since target is adjective modifying copy, paired with second copy, meaning ordinal number one in series. Sense 2 explicitly ordinal, indicating beginning unit in a series, synonyms 1st. Sense 1 broader preceding all others in time/space/degree. In genetics homologous chromosomes are copies; "first copy" isn't temporal/spatial necessarily but ordinal among copies. Best = 2. Need final only JSON. Ensure no extra.