[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: see
Target surface form: see
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=see%2:39:00:: | definition=perceive by sight or have the power to perceive by sight | examples=You have to be a good observer to see all the details; Can you see the bird in that tree?
2. sense_key=see%2:31:01:: | definition=perceive (an idea or situation) mentally | synonyms=understand, realize, realise | examples=Now I see!; I just can't see your point
3. sense_key=see%2:39:02:: | definition=perceive or be contemporaneous with | synonyms=witness, find | examples=We found Republicans winning the offices; You'll see a lot of cheating in this school
4. sense_key=see%2:36:00:: | definition=imagine; conceive of; see in one's mind | synonyms=visualize, visualise, envision, project, fancy, figure | examples=I can't see him on horseback!; I can see what will happen
5. sense_key=see%2:31:00:: | definition=deem to be | synonyms=consider, reckon, view, regard | examples=She views this quite differently from me; I consider her to be shallow
6. sense_key=see%2:31:02:: | definition=get to know or become aware of, usually accidentally | synonyms=learn, hear, get word, get wind, pick up, find out | examples=I learned that she has two grown-up children; I see that you have been promoted
7. sense_key=see%2:39:03:: | definition=see or watch | synonyms=watch, view, catch, take in | examples=view a show on television; This program will be seen all over the world
8. sense_key=see%2:38:00:: | definition=come together | synonyms=meet, run into, encounter, run across, come across | examples=I'll probably see you at the meeting; How nice to see you again!
9. sense_key=see%2:32:00:: | definition=find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, find out, ascertain, watch, learn | examples=I want to see whether she speaks French; See whether it works
10. sense_key=see%2:31:03:: | definition=be careful or certain to do something; make certain of something | synonyms=check, insure, see to it, ensure, control, ascertain | examples=He verified that the valves were closed; See that the curtains are closed
11. sense_key=see%2:41:11:: | definition=go to see for professional or business reasons | examples=You should see a lawyer; We had to see a psychiatrist
12. sense_key=see%2:41:12:: | definition=go to see for a social visit | examples=I went to see my friend Mary the other day
13. sense_key=see%2:41:10:: | definition=go to see a place, as for entertainment | synonyms=visit | examples=We went to see the Eiffel Tower in the morning
14. sense_key=see%2:41:14:: | definition=take charge of or deal with | synonyms=attend, take care, look | examples=Could you see about lunch?; I must attend to this matter
15. sense_key=see%2:35:09:: | definition=receive as a specified guest | examples=the doctor will see you now; The minister doesn't see anybody before noon
16. sense_key=see%2:41:00:: | definition=date regularly; have a steady relationship with | synonyms=go steady, go out, date | examples=Did you know that she is seeing an older man?; He is dating his former wife again!
17. sense_key=see%2:39:05:: | definition=see and understand, have a good eye | examples=The artist must first learn to see
18. sense_key=see%2:31:08:: | definition=deliberate or decide | examples=See whether you can come tomorrow; let's see--which movie should we see tonight?
19. sense_key=see%2:39:11:: | definition=observe as if with an eye | examples=The camera saw the burglary and recorded it
20. sense_key=see%2:39:13:: | definition=observe, check out, and look over carefully or inspect | synonyms=examine | examples=The customs agent examined the baggage; I must see your passport before you can enter the country
21. sense_key=see%2:39:12:: | definition=go or live through | synonyms=experience, go through | examples=We had many trials to go through; he saw action in Viet Nam
22. sense_key=see%2:38:03:: | definition=accompany or escort | synonyms=escort | examples=I'll see you to the door
23. sense_key=see%2:33:00:: | definition=match or meet | examples=I saw the bet of one of my fellow players
24. sense_key=see%2:31:13:: | definition=make sense of; assign a meaning to | synonyms=interpret, construe | examples=What message do you see in this letter?; How do you interpret his behavior?

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
Let me analyze this carefully.

Target: "see"
Context: a medical information document about Alimta. The sentence is: "For more information, see the Summary of Product Characteristics (also part of the EPAR)."

This is a common cross-reference instruction meaning "look at" or "consult" a document for further details. It's directing the reader to a source of information.

Let me look at the candidate senses:

1. perceive by sight or have the power to perceive by sight - literal seeing, not this
2. perceive (an idea or situation) mentally - understand, realize - not this
3. perceive or be contemporaneous with - witness, find - not this
4. imagine; conceive of; see in one's mind - not this
5. deem to be - consider, view, regard - not this
6. get to know or become aware of, usually accidentally - learn, hear - not this
7. see or watch - watch, view, catch, take in - examples: "view a show on television" - This is close. "See" in the sense of consulting/looking at a document.
8. come together - meet - not this
9. find out, learn, or determine - determine, check, find out - not this
10. be careful or certain - ensure - not this
11. go to see for professional or business reasons - not this
12. go to see for a social visit - not this
13. go to see a place, as for entertainment - visit - "We went to see the Eiffel Tower" - could be close but not entertainment/document
14. take charge of or deal with - attend, take care, look - "Could you see about lunch?" - not exactly
15. receive as a specified guest - not this
16. date regularly - not this
17. see and understand, have a good eye - not this
18. deliberate or decide - "See whether you can come tomorrow" - not this
19. observe as if with an eye - not this
20. observe, check out, and look over carefully or inspect - examine - "I must see your passport before you can enter the country" - This could work for examining/looking at a document
21. go or live through - experience - not this
22. accompany or escort - not this
23. match or meet - not this
24. make sense of; assign a meaning to - interpret, construe - not this

The closest are:
- 7: see or watch (view, catch, take in) - examples include "view a show on television"
- 20: observe, check out, and look over carefully or inspect (examine) - examples include examining baggage/passport
- 13: go to see a place, as for entertainment - not entertainment
- 6: learn by accident? no
- 9: determine/check? no

In documentation, "For more information, see X" is a standard cross-reference. It's instructing the reader to look at/consult/read a document.

Sense 7 "see or watch" with "watch, view, catch, take in" and example "view a show on television; This program will be seen all over the world" - this sense is about perceiving visually through media. But "see the Summary" isn't really about visual perception through TV.

Sense 20 "observe, check out, and look over carefully or inspect" with "examine" - examples: "The customs agent examined the baggage; I must see your passport before you can enter the country" - this is about inspecting documents/goods. But "For more information, see..." isn't really inspecting carefully, it's referring/looking up.

I think sense 6 could also be considered: "get to know or become aware of, usually accidentally" - but this is accidentally, and the cross-reference is intentional.

Sense 9: "find out, learn, or determine with certainty, usually by making an inquiry or other effort" - examples "I want to see whether she speaks French; See whether it works" - This involves checking/verifying, which doesn't quite fit "see the Summary."

Actually, let me reconsider. In lexicography, "see" in cross-references like "see also" or "for more information, see page X" is often considered a reference/lookup sense. In WordNet, the closest historically has been:

- see%2:39:02 perceive or be contemporaneous with; "We found Republicans winning the offices"; "You'll see a lot of cheating in this school" - not this
- see%2:31:06 get to know or become aware of, usually accidentally - "I learned that she has two grown-up children"; "I see that..."

Wait, I may have miscounted. The numbering in the prompt is not necessarily the WordNet lexicographic order. The senses given have specific sense keys. Let me look at the sense keys carefully:

sense_key=see%2:31:01:: means verb group 2, sense 31:01
The numbers after % are:
- 2 = verb
- 31 = verb.communication? or another category?
Actually, in WordNet, sense keys are "%2:XX:YY::" where XX is the lexicographer file category and YY is the sense number.

2:31 = verb.cognition
2:39 = verb.perception
2:36 = verb.creation
2:38 = verb.contact
2:32 = verb.communication
2:41 = verb.social
2:35 = verb.consumption
2:33 = verb.competition
2:31 is verb.cognition (multiple entries)

The cross-reference "see" meaning "consult/refer to" is actually WordNet's sense 7 typically: "see or watch" - "This program will be seen all over the world" - to view, to watch.

But I think the best fit for "For more information, see the Summary of Product Characteristics" is sense 7: see%2:39:03:: "see or watch" with synonyms watch, view, catch, take in. This is the standard "consult a source" usage.

However, another possibility is sense 20: see%2:39:13:: "observe, check out, and look over carefully or inspect" with synonyms examine. This is also plausible if we think of "see the Summary" as examine/inspect it.

Actually, I think in WordNet, the cross-reference "see" (as in "see p. 10") might map to a specific sense. But among the choices, I need to pick one.

Let me consider the intended meaning:
"For more information, see the Summary of Product Characteristics" = "For more information, consult/look at/read the Summary of Product Characteristics"

The phrase is about visually accessing information through a document. The intent is not just physical sight but obtaining information from a document.

In standard WSD for "see" in "see the manual", "see a dictionary", this often maps to the "look at/consult" sense. The WordNet sense that best captures this is probably:

see%2:39:03:: "see or watch" (syn: watch, view, catch, take in) - because the examples include "view a show on television" and "This program will be seen all over the world"

Or it could be the "understand/realize" sense if by "see" we mean "understand more from reading it", but that's not the cross-reference meaning.

I think the answer is sense 7 (the seventh one in the list): sense_key=see%2:39:03::

Wait, indexing in the result should match the numbered list order (1-24). So if I choose the one with sense_key=see%2:39:03::, that is candidate #7.

Let me verify: The question asks for the index of the candidate sense in the provided list. So I return {"sense_index": 7}.

Actually, I want to be more careful. Let me look at the Oxford/Cambridge sense:
"see" in cross-reference usage meaning "refer to" or "consult" - this is specifically: "to look at or read something for information" (often in written cross-references).

In WordNet terms, the closest is likely:
"view, consider, reckon, regard" (sense 5: deem to be)? No.
"watch, view, see, catch, take in" (sense 7: see or watch)? Yes.
"examine" (sense 20)? Hmm.

Looking at real WordNet mapping:
- see%2:39:03 "perceive with attention; `caught sight of' (Sophie's eyes ...)" - actually varied.

In many WSD datasets, the phrase "For more information, see ..." is consistently labeled as the "consult/look up" sense, which maps to WordNet 3.0 sense "see%2:39:03" in some versions.

Given the candidate list, I'll go with #7.

Hmm, but I also want to reconsider #20: see%2:39:13 "observe, check out, and look over carefully or inspect" with synonym examine. "I must see your passport before you can enter the country" - this example is about examining an official document. "For more information, see the Summary..." could be about inspecting/looking at the document.

But "For more information" implies the goal is to obtain information, not to scrutinize the document. That's more like "view/consult" (sense 7).

I'll go with #7.

Wait, I should also consider sense 1 "perceive by sight" - literal looking. The document is meant to be physically read with eyes. But cross-reference "see" is semantically about consulting a source, not just visual perception.

In lexicographic practice, "see v." in "see above", "see below", "for further details see...", is the reference sense. The best available match here is #7.

Final answer: {"sense_index": 7}


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: product
Target surface form: Product
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=product%1:06:01:: | definition=commodities offered for sale | synonyms=merchandise, ware | examples=good business depends on having good merchandise; that store offers a variety of products
2. sense_key=product%1:06:00:: | definition=an artifact that has been created by someone or some process | synonyms=production | examples=they improve their product every year; they export most of their agricultural production
3. sense_key=product%1:09:00:: | definition=a quantity obtained by multiplication | synonyms=mathematical product | examples=the product of 2 and 3 is 6
4. sense_key=product%1:27:00:: | definition=a chemical substance formed as a result of a chemical reaction | examples=a product of lime and nitric acid
5. sense_key=product%1:19:00:: | definition=a consequence of someone's efforts or of a particular set of circumstances | examples=skill is the product of hours of practice; his reaction was the product of hunger and fatigue
6. sense_key=product%1:14:00:: | definition=the set of elements common to two or more sets | synonyms=intersection, Cartesian product | examples=the set of red hats is the intersection of the set of hats and the set of red things

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

finish_reason: stop

role: assistant

reasoning_content:
The target word is "product" in the context of an EPAR for a medicine. "Summary of Product Characteristics" is a technical term used in regulatory/pharmaceutical contexts. It refers to the official prescribing information for a medicinal product (drug/medicine). In WordNet, the sense definition "commodities offered for sale" could loosely fit, but "an artifact that has been created by someone or some process" better captures the meaning of an authorized drug preparation. However, WordNet might have specific senses. The sentence is about Alimta, a medicine. The phrase "Product Characteristics" refers to the product as the medicine/drug itself. The best fit in WordNet is likely sense 1:06:00 "an artifact that has been created by someone or some process", because a pharmaceutical product is an artifact created by a process. But note the sense key product%1:06:00:: vs product%1:06:01::. The index is 1 of 06 with sub-id 00. In the candidate list, sense 2 is product%1:06:00:: "an artifact...". Sense 1 is product%1:06:01:: "commodities offered for sale". The target refers to the drug product (Alimta), which is created by a manufacturing process, not merchandise for sale necessarily. The context is regulatory-document label: Summary of Product Characteristics. This document concerns the medicinal product named Alimta. "Product" = the drug, an artifact. So sense 2. Let me think if there is a more standard mapping. WordNet synset product.n.02 (artifact) examples include "they improve their product every year; they export most of their agricultural production". A medicinal product fits artifact.

Could it be product as consequence? No. Chemical substance? No. Cartesian product? No. Commodities offered for sale? Could be pharmaceutical product for sale, but 'Product Characteristics' typically means properties of the product as created, not merchandise. In many WSD datasets, "product" in drug descriptions maps to product.n.02 artifact (Index 1:06:00).

So output {"sense_index": 2}.

format: unknown

native_finish_reason: stop

provider: Together

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: part
Target surface form: part
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=part%1:24:00:: | definition=something determined in relation to something that includes it | synonyms=portion, component part, component, constituent | examples=he wanted to feel a part of something bigger than himself; I read a portion of the manuscript
2. sense_key=part%1:06:00:: | definition=something less than the whole of a human artifact | synonyms=portion | examples=the rear part of the house; glue the two parts together
3. sense_key=part%1:17:00:: | definition=a portion of a natural object | synonyms=piece | examples=they analyzed the river into three parts; he needed a piece of granite
4. sense_key=part%1:09:02:: | definition=that which concerns a person with regard to a particular role or situation | examples=it requires vigilance on our part; they resisted every effort on his part
5. sense_key=part%1:15:00:: | definition=the extended spatial location of something | synonyms=region | examples=the farming regions of France; religions in all parts of the world
6. sense_key=part%1:04:01:: | definition=the actions and activities assigned to or required or expected of a person or group | synonyms=function, office, role | examples=the function of a teacher; the government must do its part
7. sense_key=part%1:09:01:: | definition=an actor's portrayal of someone in a play | synonyms=character, role, theatrical role, persona | examples=she played the part of Desdemona
8. sense_key=part%1:21:00:: | definition=assets belonging to or due to or contributed by an individual person or group | synonyms=share, portion, percentage | examples=he wanted his share in cash
9. sense_key=part%1:09:00:: | definition=one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division | examples=the written part of the exam; the finance section of the company
10. sense_key=part%1:08:01:: | definition=a line of scalp that can be seen when sections of hair are combed in opposite directions | synonyms=parting | examples=his part was right in the middle
11. sense_key=part%1:10:00:: | definition=the melody carried by a particular voice or instrument in polyphonic music | synonyms=voice | examples=he tried to sing the tenor part
12. sense_key=part%1:04:03:: | definition=the part played by a person in bringing about a result | synonyms=contribution, share | examples=I am proud of my contribution in advancing the project; they all did their share of the work

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We need choose best indexed sense for target 'part' in context: "For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR)." EPAR is European Public Assessment Report; Summary of Product Characteristics is also part of the EPAR. "part of" meaning component/constituent/member of a larger whole. Need choose among sense candidates.

Candidate 1: something determined in relation to something that includes it; portion, component part, component, constituent; examples he wanted to feel a part of something bigger; I read a portion. This fits "part of EPAR" = component of EPAR. That's lexical subpart relation.

Candidate 2: something less than the whole of a human artifact; portion; examples rear part of house; glue two parts. Not EPAR artifact physical? But EPAR is document maybe artifact but "Summary of Product Characteristics" is a subsection/document component. However part%1:06:00 specifically human artifact (object). Does EPAR a human artifact? yes, but here SPC is part of EPAR, not physical piece. But if EPAR as report/document maybe. Which sense fits better? WordNet heuristics: physical object (1:06) vs relation/subgroup component (1:24). "Summary of Product Characteristics (also part of the EPAR)" says SPC is also included in EPAR. Sense 1 includes synonyms component, constituent, portion, examples "he wanted to feel a part of something bigger than himself; I read a portion of manuscript". Sense 9: one of the portions into which something is regarded as divided and which together constitute a whole; synonyms section, division; examples the written part of the exam; finance section of company. That also plausible: part of EPAR = section of EPAR. Need decide single best.

We need use WordNet glosses. Let's recall WordNet 3.1 senses for noun "part". There are many senses. The key `part%1:24:00::` code starts 1:24:00: 'something determined in relation to something that includes it' (a general relation). 'part%1:09:00::' code 1:09:00: 'one of the portions into which something is regarded as divided and which together constitute a whole' (a section, division). 'part%1:06:00::' code 1:06:00: 'something less than the whole of a human artifact'. Given context document/report EPAR, a "Summary of Product Characteristics" is a document/text component. WordNet has sense 1:10:01? But "part" for section of text? The list includes sense 9: 'the written part of the exam; finance section of company' explicitly textual section. That fits strongly: EPAR divided into parts/sections, and SPC is also part of EPAR.

However phrase "(also part of the EPAR)" not necessarily a formal section but a relation. For "part of X" in copular construction, the most common sense is 1:24:00: "something determined in relation to something that includes it; ... he wanted to feel a part of something bigger than himself". This is the "part" sense used in "a part of something" (member/element of larger whole). Sense 9 requires portions constituting a whole, especially divisions. In context of documents: EPAR includes Summary of Product Characteristics. SPC is one of portions? It is indeed part of EPAR. But the gloss "one of the portions into which something is regarded as divided" emphasizes a segmented whole. The EPAR is divided into sections like Summary of Product Characteristics etc., so sense 9 plausible.

Need check evaluation typical mapping: In WSD tasks, "part of" with documents often maps to sense 1:24:00? Let's think. For phrase "see Summary of Product Characteristics (also part of the EPAR)" generic relation. The target surface form "part" is an in-context noun preceded by "also". "Summary of Product Characteristics is also part of the EPAR" is like saying it is a constituent/portion. Not one of the voice/partitioned portions necessarily.

Let's review definitions:
1. (relation) something determined in relation to something that includes it
2. (artifact) something less than the whole of a human artifact
3. (natural object) a portion of a natural object
4. (matter?)
5. (location) region
6. (group) actions/activities assigned ... function/office/role
7. (act) actor's portrayal
8. (possession) assets belonging/ share
9. (cognition) one of the portions into which something is regarded as divided and which together constitute a whole
10. (body) hair parting
11. (communication) melody voice
12. (act) contribution

Noun part lexicographer file counts: The index for senses:
1.行李? Actually WordNet senses for part n:
- part, portion, component part, component, constituent (n)
- part, portion (n)
- part, piece (n)
- part (n)
- part, region (n)
- function, office, part, role (n)
- character, role, theatrical role, part, persona (n)
- share, portion, part, percentage (n)
- part, section, division (n)
- part, parting (n)
- part, voice (n)
- contribution, part, share (n)

That's the order listed. So sense 1 includes "component/constituent" of a whole, but its gloss "something determined in relation to something that includes it" is quite abstract. Sense 9 "section, division" is for parts of a whole (possibly texts). Which one is correct? The phrase "part of the EPAR" - EPAR is a whole, Summary of Product Characteristics is a portion/section. Sense 9 has section and division synonyms, examples about written part of exam and finance section. SPC is a section of EPAR, so sense 9 fits more specifically.

But "part" in "Summary of Product Characteristics." "also part of EPAR" maybe "part of" in the sense of "a part of EPAR". If you can paraphrase "the SPC is also a section of the EPAR", sense 9. If paraphrase "the SPC is also a component of the EPAR", sense 1. Which is better? WordNet's first sense is the general component sense. The second is physical artifact. The third natural object. The fourth matter. Then region. Then function/role. Then persona. Then share. Then section/division. For text sections, WordNet has "part, section, division" sense 9: "one of the portions into which something is regarded as divided and which together constitute a whole". Ex: "the written part of the exam; the finance section of the company; the BBC's engineering division". Thus a document section. EPAR is a document/category, SPC is part/section. The best match likely sense 9.

However, we must be careful: In many WSD tasks, sense 1 (component) is used for generic "part of" expressions like "part of the body," "part of the problem," etc. But "part" can often be sense 9 if it is one of several similar segments/sections. For EPAR/SPC, I think sense 9 is the best because "part" = "section" of a document. Let's analyze context: EPAR = European Public Assessment Report is a medicine regulatory document. It has sections: summary of product characteristics, scientific discussion, etc. So SPC is a section/part. Sense 9.

Potential subtle issue: The encoding in candidate list uses the order shown (1-12). Use index number. We should output JSON {"sense_index": 9}. Good.

Need ensure not to hedge and only JSON object.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
7. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
13. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We need choose best WordNet sense for "active" in sentence: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine... In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes..." Target surface active. We are to map to index among listed 14. Let's inspect candidate senses. We need determine which sense corresponds to "active substance" i.e., active ingredient; exerting influence or producing change/effect. That's sense 6: definition=exerting influence or producing a change or effect; examples=an active ingredient. Also possibly active form: biologically active. In WordNet adjective sense cluster active (3:00:07?), hmm.

The provided keyed senses:
1 active%3:00:02:: tending to become more severe or wider in scope
2 active%5:00:00:operational:00 engaged in or ready for military operations
3 active%3:00:03:: disposed to take action
4 active%5:00:00:involved:00 taking part
5 active%3:00:01:: characterized by energetic activity
6 active%3:00:07:: exerting influence or producing a change or effect (active ingredient)
7 active%3:00:06:: full of activity or engaged in continuous activity
8 active%5:00:00:existent:00 in operation
9 active%3:00:10:: sun...
10 active%3:00:09:: voice constructions
11 active%3:00:00:: verbs
12 active%3:00:05:: volcanos capable of erupting
13 active%3:00:04:: volcanoes erupting or liable
14 active%3:00:08:: engaged in full-time work
We need choose index 6. So final JSON only {"sense_index": 6}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: substance
Target surface form: substance
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=substance%1:03:00:: | definition=the real physical matter of which a person or thing consists | examples=DNA is the substance of our genes
2. sense_key=substance%1:09:01:: | definition=the choicest or most essential or most vital part of some idea or experience | synonyms=kernel, core, center, centre, essence, gist | examples=the gist of the prosecutor's argument; the heart and soul of the Republican Party
3. sense_key=substance%1:09:00:: | definition=the idea that is intended | synonyms=meaning | examples=What is the meaning of this proverb?
4. sense_key=substance%1:27:00:: | definition=material of a particular kind or constitution | examples=the immune response recognizes invading substances
5. sense_key=substance%1:21:00:: | definition=considerable capital (wealth or income) | synonyms=means | examples=he is a man of means
6. sense_key=substance%1:10:00:: | definition=what a communication that is about something is about | synonyms=message, content, subject matter
7. sense_key=substance%1:03:01:: | definition=a particular kind or species of matter with uniform properties | examples=shigella is one of the most toxic substances known to man

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We need determine best sense of word "substance" in sentence: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine ..." In pharma contexts, active substance means active ingredient / chemical compound. WordNet candidate senses. Let's examine.

1 substance%1:03:00:: real physical matter of which person/thing consists. Examples DNA is substance of our genes. Here "active substance" is chemical matter in drug, specific material. But definition says "real physical matter of which a person or thing consists" - the thing (Alimta) consists of active substance? Maybe.

4 substance%1:27:00:: material of a particular kind or constitution; example immune response recognizes invading substances. This is a material of a particular kind; active substance in a medicine is a particular chemical/material.

7 substance%1:03:01:: a particular kind or species of matter with uniform properties; example shigella is one of the most toxic substances known to man. This fits "active substance" as a specific kind/species of matter with uniform properties (pemetrexed). In pharmacology, "active substance" often refers to the active chemical substance/drug substance. Example "one of the most toxic substances". It seems sense 7 is strong.

Differences between 1 and 7: 1 is "the real physical matter of which a person or thing consists" (mass/constituent matter). 7 is "a particular kind or species of matter with uniform properties" (countable kind). "active substance" can be count noun? It says "the active substance in Alimta, pemetrexed, is..." It denotes a specific chemical species (pemetrexed). So 7. In WordNet, sense 7 often for chemical substances, e.g. "toxic substances", "drugs". Sense 4 "material of a particular kind or constitution" immune response recognizes invading substances - maybe could also be chemical. But 7 includes uniform properties, particular kind/species of matter. Active substance = a particular kind of matter (pemetrexed). 4 is more generic "material of a particular kind or constitution" maybe for substances like immune invading substances, foreign substances. Could fit but 7 is more precise. In Europharma "active substance" means active substance (chemical). WordNet examples: shigella is one of the most toxic substances known to man. Active ingredient in medicine is sense 7. So choose 7.

Need output JSON only {"sense_index": 7}.

provider: Moonshot AI


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer with single JSON object sense_index. Need disambiguate "medicine" target. Context: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells)". This refers to something (a drug) that treats/prevents/alleviates symptoms of disease. Candidate sense 2: medicine%1:06:00:: definition something that treats or prevents or alleviates symptoms of disease; synonyms medication, medicament, medicinal drug. The context explicitly "a medicine that kills cells" = a drug. Also earlier "anti-emetic medicine" sense 2. So best index 2. Need only JSON exactly {"sense_index": 2}.

provider: Novita


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 The user wants me to perform Word Sense Disambiguation for the target word "medicine" in the given context. I need to choose the single best indexed sense from the 4 candidates.

Let me analyze the context:
- "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells)"
- The sentence is defining "cytotoxic medicine" as "a medicine that kills cells that are dividing, such as cancer cells"
- This refers to a substance/drug used to treat disease (cancer specifically)

Now let's look at the candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
   - This refers to the field of medicine as an area of study/science. Not the meaning here.

2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
   - This refers to a substance/drug used medically. This matches the context: "a medicine that kills cells" - a substance (pemetrexed).

3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
   - This refers to the profession of medicine. Not the meaning here.

4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine
   - This is the figurative/punishment sense. Not the meaning here.

The context clearly uses "medicine" to mean a substance/drug used for treatment/disease. Sense 2 is the best fit: "something that treats or prevents or alleviates the symptoms of disease" with synonyms medication, medicament, medicinal drug.

Note: Earlier in the context, "anti-emetic medicine" also refers to a substance, and "Summary of Product Characteristics" is about pharmaceutical drugs. The entire context is about a pharmaceutical product.

So the answer should be {"sense_index": 2}.

provider: Parasail


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: kill
Target surface form: kills
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=kill%2:35:00:: | definition=cause to die; put to death, usually intentionally or knowingly | examples=This man killed several people when he tried to rob a bank; The farmer killed a pig for the holidays
2. sense_key=kill%2:41:01:: | definition=thwart the passage of | synonyms=shoot down, defeat, vote down, vote out | examples=kill a motion; he shot down the student's proposal
3. sense_key=kill%2:30:08:: | definition=end or extinguish by forceful means | synonyms=stamp out | examples=Stamp out poverty!
4. sense_key=kill%2:42:00:: | definition=be fatal | examples=cigarettes kill; drunken driving kills
5. sense_key=kill%2:39:00:: | definition=be the source of great pain for | examples=These new shoes are killing me!
6. sense_key=kill%2:37:00:: | definition=overwhelm with hilarity, pleasure, or admiration | examples=The comedian was so funny, he was killing me!
7. sense_key=kill%2:35:06:: | definition=hit with so much force as to make a return impossible, in racket games | examples=She killed the ball
8. sense_key=kill%2:35:05:: | definition=hit with great force | examples=He killed the ball
9. sense_key=kill%2:35:02:: | definition=deprive of life | examples=AIDS has killed thousands in Africa
10. sense_key=kill%2:35:01:: | definition=cause the death of, without intention | examples=She was killed in the collision of three cars
11. sense_key=kill%2:34:00:: | definition=drink down entirely | synonyms=toss off, pop, bolt down, belt down, pour down, down | examples=He downed three martinis before dinner; She killed a bottle of brandy that night
12. sense_key=kill%2:30:00:: | definition=mark for deletion, rub off, or erase | synonyms=obliterate, wipe out | examples=kill these lines in the President's speech
13. sense_key=kill%2:30:04:: | definition=tire out completely | examples=The daily stress of her work is killing her
14. sense_key=kill%2:30:03:: | definition=cause to cease operating | examples=kill the engine
15. sense_key=kill%2:30:02:: | definition=destroy a vitally essential quality of or in | examples=Eating artichokes kills the taste of all other foods

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 We need select best sense index for kill (kills) in context. Context: pemetrexed is cytotoxic medicine that kills cells that are dividing, such as cancer cells. It blocks enzymes etc. This is literal cause death of cells: cause to die; put to death, usually intentionally or knowingly? But cells? Also sense 9: deprive of life. Sense 1 definition "cause to die; put to death, usually intentionally or knowingly" examples people, pig. Sense 9 "deprive of life" example AIDS has killed thousands. For medicine kills cells, likely sense 1 or 9. Need choose single best. WordNet kill senses: kill%2:35:00 cause to die; put to death (agent). kill%2:35:02 deprive of life (maybe also transitive but used for diseases etc). Let's inspect WordNet kill verb senses. kill.v.01 cause to die. kill.v.02 kill (cause the death of, without intention). Hmm. For "AIDS has killed thousands in Africa" is v?09 "deprive of life". Actually WordNet kill v 09 "deprive of life" may be same? Let's recall all synsets: kill.v.01: cause to die; put to death, usually intentionally or knowingly. kill.v.02: cause the death of, without intention. kill.v.03: end or extinguish. kill.v.04: be fatal. kill.v.05: be the source of great pain. kill.v.06: overwhelm with hilarity. kill.v.07: hit with so much force as to make return impossible. kill.v.08: hit with great force. kill.v.09: deprive of life. kill.v.10: drink down. kill.v.11: mark for deletion. kill.v.12: tire out. kill.v.13: cause to cease operating. kill.v.14? Wait counts differ. But candidate sense keys listed. The key kill%2:35:00 corresponds to cause to die; kill%2:35:02 deprive of life. Which applies for drugs killing cells? "kill cells" cause to die. Deprive of life for cells? It might be considered causing to die. But in biomedical text, "kills cells" likely sense 1 "cause to die". However "cells dividing" maybe not intentionally, but medicine intentionally kills. The examples include farmer killed pig. For drugs causing cell death, "cause to die" is best. Sense 9 "deprive of life" includes disease, but drugs may also deprive of life. Need use schematic: cytotoxic medicine that kills cells => puts to death cells. Choose index 1.

But must ensure final answer only JSON object exactly like {"sense_index": 1}.

provider: Ambient


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cells
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer only JSON with sense_index. Need choose best sense for cells in context: kills cells that are dividing such as cancer cells; nucleotides building blocks DNA/RNA genetic material of cells. This is biological basic unit. Candidate sense 2. Return {"sense_index": 2}. Ensure final only JSON.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: divide
Target surface form: dividing
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=divide%2:41:00:: | definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire after World War I
2. sense_key=divide%2:31:00:: | definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven?
3. sense_key=divide%2:42:00:: | definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries
4. sense_key=divide%2:35:00:: | definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated
5. sense_key=divide%2:38:00:: | definition=make a division or separation | synonyms=separate
6. sense_key=divide%2:35:01:: | definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 We need select best indexed sense for target lemma divide, surface dividing, context: cells that are dividing, such as cancer cells. This is biological cell division. Candidate senses from WordNet:
1 separate into parts or portions (split etc)
2 perform a division arithmetic
3 act as barrier between; stand between
4 come apart (separate)
5 make a division or separation
6 force, take, or pull apart

In WordNet, cell division likely maps to "separate into parts or portions" sense? Let's see. The schematic WordNet sense divide%2:41:00:: "separate into parts or portions" includes split, split up, separate, dissever, carve up. For cells dividing, "cells that are dividing" = undergoing cell division, splitting into two. Sense 1 (separate into parts or portions) is best. Sense 5 "make a division or separation" maybe less common. Cell division sense in WordNet is likely "divide, split, split up, separate, dissever, carve up" (sense 2:41:00). Yes that is sense 1.

Need return JSON only {"sense_index": 1}. Ensure no extra explanation.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: body
Target surface form: body
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=body%1:08:00:: | definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
2. sense_key=body%1:14:00:: | definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium; the student body
3. sense_key=body%1:08:02:: | definition=a natural object consisting of a dead animal or person | synonyms=dead body | examples=they found the body in the lake
4. sense_key=body%1:17:00:: | definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. sense_key=body%1:08:01:: | definition=the body excluding the head and neck and limbs | synonyms=torso, trunk | examples=they moved their arms and legs and bodies
6. sense_key=body%1:14:02:: | definition=a collection of particulars considered as a system | examples=a body of law; a body of doctrine
7. sense_key=body%1:07:00:: | definition=the property of holding together and retaining its shape | synonyms=consistency, consistence, eubstance | examples=wool has more body than rayon; when the dough has enough consistency it is ready to bake
8. sense_key=body%1:10:00:: | definition=the central message of a communication | examples=the body of the message was short
9. sense_key=body%1:07:01:: | definition=the main mass of a thing
10. sense_key=body%1:06:01:: | definition=a resonating chamber in a musical instrument (as the body of a violin) | synonyms=soundbox
11. sense_key=body%1:06:00:: | definition=the external structure of a vehicle | examples=the body of the car was badly rusted

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need choose best sense for 'body' in context: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes..." This refers to the human organism/entire physical structure. Candidate sense 1: the entire structure of an organism. That fits. We need answer JSON with sense_index. Ensure only JSON object exactly like {"sense_index": 3}. So {"sense_index": 1}.

provider: DeepInfra


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: convert
Target surface form: converted
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=convert%2:30:00:: | definition=change from one system to another or to a new plan or policy | synonyms=change over | examples=We converted from 220 to 110 Volt
2. sense_key=convert%2:30:03:: | definition=change the nature, purpose, or function of something | examples=convert lead into gold; convert hotels into jails
3. sense_key=convert%2:30:01:: | definition=change religious beliefs, or adopt a religious belief | examples=She converted to Buddhism
4. sense_key=convert%2:30:02:: | definition=exchange or replace with another, usually of the same kind or category | synonyms=change, exchange, commute | examples=Could you convert my dollars into pounds?; He changed his name
5. sense_key=convert%2:30:07:: | definition=cause to adopt a new or different faith | examples=The missionaries converted the Indian population
6. sense_key=convert%2:33:02:: | definition=score an extra point or points after touchdown by kicking the ball through the uprights or advancing the ball into the end zone | examples=Smith converted and his team won
7. sense_key=convert%2:33:01:: | definition=complete successfully | examples=score a penalty shot or free throw
8. sense_key=convert%2:33:00:: | definition=score (a spare)
9. sense_key=convert%2:32:00:: | definition=make (someone) agree, understand, or realize the truth or validity of something | synonyms=win over, convince | examples=He had finally convinced several customers of the advantages of his product
10. sense_key=convert%2:30:09:: | definition=exchange a penalty for a less severe one | synonyms=commute, exchange
11. sense_key=convert%2:30:04:: | definition=change in nature, purpose, or function; undergo a chemical change | examples=The substance converts to an acid

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer JSON. Need choose best indexed sense for target 'converted' in sentence: 'In the body, pemetrexed is converted into an active form that blocks...' This is passive form of convert. It describes chemical transformation of substance in body into active form. Candidate senses: #2 change the nature, purpose, or function of something; examples convert lead into gold. #11 change in nature, purpose, or function; undergo a chemical change examples The substance converts to an acid. Since it's passive 'is converted into...' maybe equivalent to undergo a chemical change? Or change the nature? In WordNet indexing, convert%2:30:04 definition change in nature, purpose, or function; undergo a chemical change. That seems most apt for chemical transformation. However target surface form is converted and context says pemetrexed is converted into an active form; active form is due to body's enzymes (chemical change). Sense 11. We should return index 11. Ensure JSON exactly {"sense_index": 11}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
7. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
13. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need choose best sense for adjective "active" in phrase: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes..." Context: active form = form that has biological/chemical activity, i., exerting influence or producing a change or effect. Candidate sense 6: active%3:00:07:: definition=exerting influence or producing a change or effect, examples=an active ingredient. That fits. Need output JSON only. Index 6. Ensure no extra.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: form
Target surface form: form
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=form%1:10:00:: | definition=the phonological or orthographic sound or appearance of a word that can be used to describe or identify something | synonyms=word form, signifier, descriptor | examples=the inflected forms of a word can be represented by a stem and a list of inflections to be attached
2. sense_key=form%1:09:01:: | definition=a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety | examples=sculpture is a form of art; what kinds of desserts are there?
3. sense_key=form%1:09:00:: | definition=a perceptual structure | synonyms=shape, pattern | examples=the composition presents problems for students of musical form; a visual pattern must include not only objects but the spaces between them
4. sense_key=form%1:07:01:: | definition=any spatial attributes (especially as defined by outline) | synonyms=shape, configuration, contour, conformation | examples=he could barely make out their shapes
5. sense_key=form%1:08:00:: | definition=alternative names for the body of a human being | synonyms=human body, physical body, material body, soma, build, figure | examples=Leonardo studied the human body; he has a strong physique
6. sense_key=form%1:03:00:: | definition=the spatial arrangement of something as distinct from its substance | synonyms=shape | examples=geometry is the mathematical science of shape
7. sense_key=form%1:07:00:: | definition=the visual appearance of something or someone | synonyms=shape, cast | examples=the delicate cast of his features
8. sense_key=form%1:10:01:: | definition=a printed document with spaces in which to write | examples=he filled out his tax form
9. sense_key=form%1:14:02:: | definition=(biology) a group of organisms within a species that differ in trivial ways from similar groups | synonyms=variant, strain, var. | examples=a new strain of microorganisms
10. sense_key=form%1:10:02:: | definition=an arrangement of the elements in a composition or discourse | examples=the essay was in the form of a dialogue; he first sketches the plot in outline form
11. sense_key=form%1:07:03:: | definition=a particular mode in which something is manifested | examples=his resentment took the form of extreme hostility
12. sense_key=form%1:26:00:: | definition=(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary | synonyms=phase | examples=the reaction occurs in the liquid phase of the system
13. sense_key=form%1:14:00:: | definition=a body of students who are taught together | synonyms=class, grade, course | examples=early morning classes are always sleepy
14. sense_key=form%1:07:02:: | definition=an ability to perform well | examples=he was at the top of his form; the team was off form last night
15. sense_key=form%1:06:00:: | definition=a life-size dummy used to display clothes | synonyms=mannequin, manikin, mannikin, manakin
16. sense_key=form%1:06:01:: | definition=a mold for setting concrete | examples=they built elaborate forms for pouring the foundation

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to choose the correct sense for the word "form" in the given context.

Context: "In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes..."

We are talking about a chemical compound (pemetrexed) being converted into an active form. This is a chemical/biochemical sense.

Let me look at the candidates:

1. form%1:10:00:: - word form, signifier - no, not about words
2. form%1:09:01:: - category/kind/variety - "active form" could be loosely interpreted, but not exactly
3. form%1:09:00:: - perceptual structure/shape/pattern - no
4. form%1:07:01:: - spatial attributes by outline - no
5. form%1:08:00:: - human body - no
6. form%1:03:00:: - spatial arrangement - no
7. form%1:07:00:: - visual appearance - no
8. form%1:10:01:: - printed document - no
9. form%1:14:02:: - biology variant/strain/var. - "a new strain of microorganisms" - also possible, but here it's about chemical form
10. form%1:10:02:: - arrangement of elements in composition - no
11. form%1:07:03:: - particular mode in which something is manifested - "active form" as a mode of manifestation - possible
12. form%1:26:00:: - distinct state of matter in physical chemistry; phase - "matter that is identical in chemical composition and physical state" - this is about physical chemistry. But pemetrexed being converted into an active form is more about chemical structure/biochemistry
13. form%1:14:00:: - class of students - no
14. form%1:07:02:: - ability to perform - no
15. form%1:06:00:: - mannequin - no
16. form%1:06:01:: - mold for concrete - no

Now, the context says "pemetrexed is converted into an active form." In chemistry, an active form would typically refer to a particular chemical variant or metabolite. But in WordNet...

WordNet "form" has several relevant senses. The most relevant are probably:
- sense 12: physical chemistry - a distinct state of matter in a system (phase)
- sense 9: biology - a group of organisms within a species that differ in trivial ways from similar groups
- sense 2: kind/variety

Actually, "active form" in chemistry is often about the active metabolite or active chemical species of a drug. But WordNet may not have a specific chemical sense.

Let me think about which is closest in standard WordNet taxonomy.

For "active form" referring to a chemical substance, WordNet's sense 1:26:00 (physical chemistry) "distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary; 'the reaction occurs in the liquid phase of the system'" - this seems like "phase" not "form" as an active compound.

Actually, in the original WordNet, sense 12 is "(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary; 'the reaction occurs in the liquid phase of the system'" with synonyms {form, phase}. So "form" here is the "phase" meaning (solid form, liquid form, gaseous form).

But "active form" of a drug is not really a phase.

Sense 2 is "a category of things distinguished by some common characteristic or quality; 'sculpture is a form of art'; 'what kinds of desserts are there?'" This is "kind" and could potentially work if "active form" means "active kind" but it's a bit stretched.

Sense 11 is "a particular mode in which something is manifested; 'his resentment took the form of extreme hostility'; 'the occasion is not likely to recur in a form like this one'". This could fit: pemetrexed in its active form (manifestation/mode) blocks enzymes.

Actually, in many WSD datasets, "form" when referring to chemical/biological forms is often labeled as sense 2 or sense 9 or sense 11 depending on nuance.

Wait, let me reconsider. The phrase "converted into an active form" - the drug is converted from inactive to active form. This "form" is a particular state or manifestation of the substance.

I think sense 12 (physical chemistry, phase) might actually be indicated because the domain is chemistry/biology. But "active form" of a drug is not about phase boundaries.

Let me look more carefully at WordNet's classification. Many WordNet disambiguation systems use sense 2 "(kind, sort, variety)" for things like "vitamin in pill form" or "art form" etc.

Actually, I recall that in WordNet, "form" in the sense of "chemical compound form" or "isomeric form" or "active form" often maps to sense 1:09:01:: "category of things distinguished by some common characteristic or quality" because it's a "kind" or "variety" of the substance.

But there's also sense 1:26:00:: for physical chemistry. Let me think if active form of a substance could be considered a "phase" - no.

Hmm, but in the context of "converted into an active form that blocks...", the "form" is a chemical entity. WordNet might not have a perfect fit.

Let me reconsider sense 9: "form%1:14:02:: - (biology) a group of organisms within a species that differ in trivial ways from similar groups; synonyms=variant, strain, var.; examples=a new strain of microorganisms."

No, this is about biological organisms, not chemical compounds.

Let me look at the candidates again. The most commonly used sense for "drug form" might be sense 2 "kind, sort, variety" - but actually it's more like sense 11 or 12.

Given the domain (pharmacology/chemistry), and "active form" meaning a particular chemical state or manifestation, I would choose either 2, 11, or 12.

In WordNet, "active form" in medical contexts is frequently sense 2: "a category of things distinguished by common characteristic or quality" because all medicinal "forms" (tablet form, liquid form, active form) are varieties or kinds of a substance.

But wait - "liquid form", "solid form", "gaseous form" would map to sense 12 (phase). "Inactive form" vs "active form" of a drug could be considered a chemical form that's a phase-like distinction.

I think I need to make a judgment call. Let me think about the examples provided:
- Sense 12 examples: "the reaction occurs in the liquid phase of the system" - this is about physical state/phase
- Sense 2 examples: "sculpture is a form of art; what kinds of desserts are there?" - categories
- Sense 11 examples: "his resentment took the form of extreme hostility" - manifestation

The context says "pemetrexed is converted into an active form" - this means after metabolism, it becomes an active chemical species. The "active form" is the active manifestation of pemetrexed.

For WSD of "form" in such contexts, I would likely select sense 2 or 11. Actually, I think sense 2 has been commonly used for "vitamin ... form", "sugar form", "active form" - when the word refers to a kind/type of the substance.

But I want to be more careful. Let me think about the actual WordNet hierarchy.

WordNet "form" has:
- 1:10:00: word form (linguistic)
- 1:09:01: kind, sort, variety
- 1:09:00: shape, pattern (perceptual structure)
- 1:07:01: shape, configuration (spatial attributes)
- ...
- 1:07:03: particular mode (manifestation)
- 1:26:00: phase (physical chemistry)
- 1:14:02: strain (biology)

Given the phrase "active form", in chemical/biochemical context, I recall examples like "the active form of vitamin D" or "in its active form". This is typically categorized in WordNet as sense ... hmm.

You know, actually, I think the best fit might be sense 12 (physical chemistry) because we're dealing with chemistry (pemetrexed is a chemical/antimetabolite). "Active form" could loosely map to a "phase" or distinct state of matter in biological/chemical system. But it's not quite right.

Actually wait - "form" in "chemical form" can be a chemistry sense in some specialized dictionaries, but WordNet doesn't have a specific chemistry sense beyond sense 12 (phase).

Let me consider sense 2 again. "Active form" as "active kind" of the drug - this actually works pretty well semantically: pemetrexed exists as a category/type called "active form".

I've seen in some WSD gold labels, "form" in similar pharmaceutical contexts labeled as sense 2. For example, "...in its phosphorylated form" or "...activated form" often maps to WordNet sense 2.

But actually, I want to think about whether "active form" is closer to "phase" (a chemical/physical state). In physical chemistry, "form" and "phase" are often synonymous - like a substance existing in different forms (solid, liquid, gas). An "active form" is not a phase of matter though - it's still dissolved/aqueous typically.

I think the answer is likely sense 2: "a category of things distinguished by some common characteristic or quality." The "active form" of pemetrexed is the category of the compound distinguished by being enzymatically active.

Alternatively it could be sense 12 if they are treating it as a "phase/state" distinction in a chemical system.

Given the instruction to use context, examples, and synonyms:
- The synonyms for sense 2 are "kind, sort, variety" - we can say "pemetrexed in its active kind/sort/variety" - awkward but somewhat meaningful
- The synonyms for sense 12 are "phase" - "pemetrexed in its active phase" - also somewhat meaningful chemically
- The synonyms for sense 11 are "particular mode" - not really

Hmm, "active form" vs "inactive form" often relates to chemical isomers or phosphorylated states. It could be treated as a "variety" (sense 2) or a "phase/state" (sense 12).

Let me also reconsider sense 14:02:: biology. Could "active form" map to "strain/variant"? A variant of pemetrexed? Not really, it's still pemetrexed that's been converted.

And what about sense 1:10:00:: word form? No, definitely not linguistic.

I think the most defensible answer is **sense 2** (kind/sort/variety) because:
1. The phrase "converted into an active form" means it becomes a kind/type/state of the compound
2. In WordNet, medicinal forms (e.g., "pill form", "liquid form", "active form") are frequently labeled as kind/sort/variety
3. The examples "sculpture is a form of art" are parallel to "pemetrexed in its active form is a form of cytotoxic medicine" - it's a category

Alternatively sense 12 might fit if we interpret "form" strictly as "phase" in a physical/chemical system. But "active phase" doesn't sound right for an active metabolite.

Actually, maybe I should look more carefully. The word "form" in "active form" in the context of drug metabolism often means an isomeric or chemical form. For instance:
- "Pemetrexed is converted into an active form" - this active form is the polyglutamated form in cells.
- "The active form of folate"

In these cases, "form" likely maps to sense 2 "kind, sort, variety" in WordNet.

I will go with sense 2.

Wait, but let me think one more time. There's also sense 1:10:01:: document form. No. Sense 1:14:00:: class. No.

Could it be sense 9? No, biology organisms.

Final decision: sense 2.

Actually, I want to double check whether "active form" might be sense 1:26:00::. The example "the reaction occurs in the liquid phase" - the "form" here means "phase" which is a state of matter. But active form of a drug is not a state of matter like solid/liquid/gas. It's an activated chemical state. So I don't think sense 12 is right.

OK, final answer: 2.

Hmm, wait. I just realized I should think about WordNet's specific phrase "a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary" for sense 12. This says matter identical in chemical composition. But pemetrexed being converted to an active form means it's a different chemical composition (metabolized/polyglutamated). So sense 12 is not appropriate because it requires identical chemical composition.

Therefore sense 2 is more appropriate.

Actually, even sense 12's "distinct state of matter" is not quite right because pemetrexed is converted chemically. So sense 2 (kind, sort, variety) better captures "a category of chemical entities distinguished by activity".

Final answer: 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: block
Target surface form: blocks
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=block%2:35:00:: | definition=render unsuitable for passage | synonyms=barricade, blockade, stop, block off, block up, bar | examples=block the way; barricade the streets
2. sense_key=block%2:41:00:: | definition=hinder or prevent the progress or accomplishment of | synonyms=obstruct, blockade, hinder, stymie, stymy, embarrass | examples=His brother blocked him at every turn
3. sense_key=block%2:41:01:: | definition=stop from happening or developing | synonyms=stop, halt, kibosh | examples=Block his election; Halt the process
4. sense_key=block%2:32:00:: | definition=interfere with or prevent the reception of signals | synonyms=jam | examples=Jam the Voice of America; block the signals emitted by this station
5. sense_key=block%2:41:03:: | definition=run on a block system | examples=block trains
6. sense_key=block%2:39:05:: | definition=interrupt the normal function of by means of anesthesia | examples=block a nerve; block a muscle
7. sense_key=block%2:39:00:: | definition=shut out from view or get in the way so as to hide from sight | synonyms=obstruct | examples=The thick curtain blocked the action on the stage; The trees obstruct my view of the mountains
8. sense_key=block%2:35:03:: | definition=stamp or emboss a title or design on a book with a block | examples=block the book cover
9. sense_key=block%2:35:02:: | definition=obstruct | synonyms=stuff, lug, choke up | examples=My nose is all stuffed; Her arteries are blocked
10. sense_key=block%2:35:12:: | definition=block passage through | synonyms=obstruct, obturate, impede, occlude, jam, close up | examples=obstruct the path
11. sense_key=block%2:35:06:: | definition=support, secure, or raise with a block | examples=block a plate for printing; block the wheels of a car
12. sense_key=block%2:33:00:: | definition=impede the movement of (an opponent or a ball) | synonyms=parry, deflect | examples=block an attack
13. sense_key=block%2:31:00:: | definition=be unable to remember | synonyms=forget, blank out, draw a blank | examples=I'm drawing a blank; You are blocking the name of your first wife!
14. sense_key=block%2:30:01:: | definition=shape by using a block | examples=Block a hat; block a garment
15. sense_key=block%2:30:00:: | definition=shape into a block or blocks | examples=block the graphs so one can see the results clearly
16. sense_key=block%2:30:02:: | definition=prohibit the conversion or use of (assets) | synonyms=freeze, immobilize, immobilise | examples=Blocked funds; Freeze the assets of this hostile government

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to disambiguate the word "blocks" in a biomedical context about Alimta/pemetrexed. Let me analyze the context.

The sentence is: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides."

So "blocks" here means it prevents/stops the activity of enzymes. It's inhibiting enzyme function.

Let me look at the candidate senses:

1. block%2:35:00 - render unsuitable for passage (physical blocking, barricade)
2. block%2:41:00 - hinder or prevent the progress or accomplishment of
3. block%2:41:01 - stop from happening or developing
4. block%2:32:00 - interfere with signals
5. block%2:41:03 - run on a block system (trains)
6. block%2:39:05 - interrupt normal function by anesthesia
7. block%2:39:00 - shut out from view
8. block%2:35:03 - emboss with a block
9. block%2:35:02 - obstruct (stuff, choke up) - physical obstruction
10. block%2:35:12 - block passage through
11. block%2:35:06 - support with a block
12. block%2:33:00 - impede movement of opponent/ball
13. block%2:31:00 - be unable to remember
14. block%2:30:01 - shape by using a block
15. block%2:30:00 - shape into blocks
16. block%2:30:02 - prohibit conversion/use of assets

The context is about an enzyme's activity being blocked. This is about hindering/preventing the function/progress of something.

Sense 2: "hinder or prevent the progress or accomplishment of" - synonyms obstruct, blockade, hinder, stymie. Examples: "His brother blocked him at every turn"

Sense 3: "stop from happening or developing" - synonyms stop, halt, kibosh. Examples: "Block his election; Halt the process"

Sense 9: "obstruct" with synonyms stuff, lug, choke up. Examples: "My nose is all stuffed; Her arteries are blocked"

This is a tricky choice. In biomedical contexts, when we say a drug "blocks" enzyme activity, we typically mean it inhibits or prevents the enzyme from functioning.

Sense 2 (block%2:41:00) is "hinder or prevent the progress or accomplishment of" - this seems to fit well with blocking enzyme activity, as it hinders the enzyme's function.

Sense 3 (block%2:41:01) is "stop from happening or developing" - this could also fit, as it stops the enzyme activity from happening.

Sense 9 (block%2:35:02) "obstruct" with examples about arteries being blocked - this is more physical obstruction.

In biomedical literature, "block" in the sense of enzyme inhibition is usually closest to sense 2 or 3. Let me think more carefully.

The phrase "blocks the activity" - it's blocking the activity (the process/function) of enzymes. This is about preventing the progress/accomplishment of the enzyme's function.

Actually, in WordNet disambiguation tasks, when a substance "blocks" an enzyme or receptor, the typical sense is often sense 2 (hinder or prevent the progress or accomplishment of) or sometimes sense 9 (obstruct).

But let me think about the exact meaning. "Blocks the activity of enzymes" - the active form of pemetrexed inhibits the enzymes. It hinders/prevents them from carrying out their function.

Sense 2: hinder or prevent the progress or accomplishment of
Sense 3: stop from happening or developing

"Block his election" = prevent the election from happening
"Block the activity" = prevent the activity from occurring

I think sense 2 is the best fit because "blocks the activity of enzymes" is about hindering/preventing the progress or accomplishment of the enzymes' function, not stopping an event from happening.

Actually, looking at this more carefully, in many WSD datasets, when "block" is used in a biological/chemical context like "blocks the enzyme" or "blocks the receptor," it's often annotated as sense 2 (hinder or prevent the progress or accomplishment of) or sense 9 (obstruct).

Let me reconsider sense 9: "obstruct" with examples "Her arteries are blocked." This is about physically obstructing a passage. An enzyme isn't a passage, so this doesn't fit well.

Sense 2: "hinder or prevent the progress or accomplishment of" - This fits abstract processes like enzyme activity.

Sense 3: "stop from happening or developing" - This is more about events/processes.

The activity of an enzyme is a process. Blocking the activity means stopping that process from happening. But it could also be hindering it.

In the context: "blocks the activity of the enzymes that are involved in producing nucleotides" - this is clearly about hindering/preventing the enzymes from doing their job, which hinders the production of nucleotides.

I think sense 2 (block%2:41:00) is the best answer. But I want to be careful because sense 3 could also be argued.

Let me look at the examples again:
- Sense 2: "His brother blocked him at every turn" - preventing someone's progress
- Sense 3: "Block his election; Halt the process" - stopping an event/process

"Blocks the activity" is closer to "halt the process" in that the activity is a process. But "activity" is more of a function than an event.

In biomedical terminology, "enzyme blocker" or "blocks enzyme activity" is an inhibition. The WordNet sense that best captures inhibition of function is sense 2: hinder or prevent the progress or accomplishment of.

I'll go with sense 2.