[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: dose
Target surface form: dose
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the <t>dose</t> reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=dose%1:06:00:: | definition=a measured portion of medicine taken at any one time | synonyms=dosage
2. sense_key=dose%1:23:00:: | definition=the quantity of an active agent (substance or radiation) taken in or absorbed at any one time | synonyms=dosage
3. sense_key=dose%1:26:00:: | definition=a communicable infection transmitted by sexual intercourse or genital contact | synonyms=venereal disease, VD, venereal infection, social disease, Cupid's itch, Cupid's disease
4. sense_key=dose%1:06:01:: | definition=street name for lysergic acid diethylamide | synonyms=acid, back breaker, battery-acid, dot, Elvis, loony toons

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 We need choose best indexed sense. Target 'dose' in sentence: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects." Context about medication Alimta, chemotherapy, measured amount 500 mg per m2. The word here refers to the amount/administration of medicine, which can be a measured portion of medicine (sense 1) or quantity of active agent (sense 2). Need decide between dose%1:06:00 and dose%1:23:00.

WordNet senses:
1. noun artifact? Actually 1:06 is noun.artifact? A measured portion of medicine taken at any one time. synonyms dosage.
2. noun.quantity? 1:23 is noun.quantity? the quantity of an active agent taken in or absorbed at any one time. synonyms dosage.

The context explicitly medicine "Alimta" and "recommended dose of Alimta is 500 mg per square metre". This seems a measured portion of medicine. However "quantity of an active agent" also fits for dosage in mg. Need deduce best indexed sense based on possible distinctions.

"dose" in pharmacology can refer to measured amount of medicine or radiation. WordNet separates artifact (a measured portion of medicine taken at any one time) and quantity (the quantity of an active agent, substance or radiation, taken in or absorbed at any one time). The examples? Without examples. The target instance: "the dose reduced" refers to the amount of medicine/Alimta. Since it is a measured portion of medicine, sense 1 likely. But is 'dose reduced' maybe referring to "dosage" meaning quantity? They mention recommended dose 500 mg per m²; that's a quantity. But "dose" in medicine typically sense 1? In WordNet both map to dosage. The surface "dose" in chemotherapy context. We need choose.

Let's examine WordNet sense examples:
dose%1:06:00:: "a measured portion of medicine taken at any one time" perhaps examples: take a dose of cough medicine. It classifies as noun.artifact? Wait 1:06 = noun.artifact (objects). "Measured portion" implies a physical amount to be administered, could be a tablet/infusion.
dose%1:23:00:: noun.quantity "the quantity of an active agent (substance or radiation) taken in or absorbed at any one time" examples might include "a dose of radiation".

Target mentions "dose reduced" and "recommended dose" with specific mg/m2. That's a quantity of active agent (Alimta). But it is definitely medicine, not radiation or active agent generically. Sense 1 is more specific to medicine. Which is "single best"? WSD tasks: If context is about medicine taken at one time, sense 1 is appropriate. But if the dose is quantified in mg (an amount), sense 2 maybe. However, sentence includes "medicine" and "take a corticosteroid and folic acid, and receive injections". The dose refers to amount of Alimta (a medicine). In Example: "The recommended dose of Alimta is 500 mg per square metre". This sounds like a measured portion of medicine. I'd Lean sense 1.

We need output only JSON {"sense_index": X}. Index matching candidate order: 1,2,3,4. So answer 1 or 2. Need final decision.

Let's analyze subtle WN hierarchy. Dose noun.
- Sense 1: measured portion of medicine taken at any one time (artifact).
- Sense 2: quantity of active agent (substance or radiation) taken in or absorbed at any one time (quantity).
Given target: "cisplatin dose" and "Alimta dose". Cisplatin and Alimta are medicines. The phrase 'dose' can be measured in mg per m2; that might be quantity of active agent. But both are medicines.

Could context "received injections" and "intravenous infusion" support that it's a portion of medicine administered. The definition uses "taken at any one time"; given via infusion over 10 minutes; yes.

Need choose single best. Since WSD using glosses: The context is specifically medicine, sense 1 includes medicine explicitly. Sense 2 broader includes radiation/substance; but active agent could be Alimta. WordNet WSD usually picks the most specific applicable? Not always. But in "medicine" domain, "dose" often maps to sense 1 (drug). Yet "recommended dose is 500 mg per m²" is dose as a quantity.

Let's search memory of WordNet mappings. Lexical overlap: definition of sense 1 = "measured portion of medicine taken at any one time." Target context has "medicine" words: anticancer chemotherapy, Alimta, corticosteroid, cisplatin, anti-emetic. This strongly supports sense 1. Sense 2 gloss "active agent, substance or radiation" less specific. Best index likely 1.

But there is a nuance: The word "dose" in "to reduce the dose" may refer to the dosage (quantity). The synonym 'dosage' is shared. However ask choose single best indexed sense. If the target is a noun.quantity, maybe because "dose" is quantifiable and definition as quantity fits numerical doses. But the object is medicine. The word's hypernym for sense1 is 'dosage'? Actually both may be.

Let's consider possible evaluation dataset maybe from WordNet mapping; target is "dose%1:23:00::" commonly for "dose of radiation" or "dose of medicine"? Many WSD corpora annotate "dose" in medical contexts as sense 2 because it appears as "dose" meaning quantity of an active agent. Sense 1 perhaps "a measured portion of medicine taken at any one time" as in a pill. The context involves intravenous infusion of an anticancer drug, an amount, not a "portion" perhaps. But "measured portion" can be amount of infusion. Hmm.

Let's see actual WordNet examples from memory for dose noun:
- dose%1:06:00:: => a measured portion of medicine taken at any one time. Examples: {he took a dose of cough medicine}; maybe synonyms dosage.
- dose%1:23:00:: => the quantity of an active agent (substance or radiation) taken in or absorbed at any one time. Synonyms dosage. Examples: {the more he took, the more he needed};

In medical/pharma contexts, "dose" is often sense 2? Let's reason: "the recommended dose is 500 mg per m2" is not a physical "portion" but a quantity. If you reduce the dose, you reduce the quantity. This matches sense 2's "quantity of an active agent". But also matches sense 1's "measured portion of medicine".

Could use sysnets: dose.n.01 vs dose.n.02. dose.n.01 "a measured portion of medicine taken at any one time" is a hyponym of "medicine"? Actually hypernyms dosage, medicament. dose.n.02 "the quantity of an active agent (substance or radiation) taken in or absorbed at any one time" hypernyms magnitude? Let's recall.

Maybe ask as English linguist performing fine-grained WSD. They want choose sense using context, examples, synonyms. They instruct do not hedge. Output JSON only.

We need make a final call. I think sense 1 is better because the target refers specifically to a measured portion of the medicine Alimta, given to patients. The entire context is about medication administration. Sense 2 includes radiation and active agent generically, less apt. Also phrase "the dose reduced" in patient treatment—the dose of medication. Thus select sense 1.

But I want to double-check by considering if recommended dose 500 mg/m2 is "quantity of an active agent". In pharmacology, "dose" is the amount of a drug, measured in mg. WordNet sense 2 is "the quantity of an active agent". That seems to directly describe recommendations in mg. Sense 1 "a measured portion of medicine taken at any one time" might also be but "medicine" is "Alimta" (medicine). The presence of "medicine" synonyms in sense1 is strong. The presence of "radiation" in sense2 is distracting; no radiation in context. Therefore sense1 likely.

Let's decide to answer index 1.

One consideration: The surface form "dose" appears as "cisplatin dose". Cisplatin is an anti-cancer chemotherapy drug (medicine). "dose reduced" refers to Alimta. Yes.

Final JSON only.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: reduce
Target surface form: reduced
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose <t>reduced</t>, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=reduce%2:30:00:: | definition=cut down on; make a reduction in | synonyms=cut down, cut back, trim, trim down, trim back, cut | examples=reduce your daily fat intake; The employer wants to cut back health benefits
2. sense_key=reduce%2:30:06:: | definition=make less complex | examples=reduce a problem to a single question
3. sense_key=reduce%2:41:00:: | definition=bring to humbler or weaker state or condition | examples=He reduced the population to slavery
4. sense_key=reduce%2:40:04:: | definition=simplify the form of a mathematical equation of expression by substituting one term for another
5. sense_key=reduce%2:37:00:: | definition=lower in grade or rank or force somebody into an undignified situation | examples=She reduced her niece to a servant
6. sense_key=reduce%2:30:11:: | definition=be the essential element | synonyms=come down, boil down | examples=The proposal boils down to a compromise
7. sense_key=reduce%2:30:05:: | definition=reduce in size; reduce physically | synonyms=shrink | examples=Hot water will shrink the sweater; Can you shrink this image?
8. sense_key=reduce%2:40:00:: | definition=lessen and make more modest | examples=reduce one's standard of living
9. sense_key=reduce%2:30:04:: | definition=make smaller | synonyms=scale down | examples=reduce an image
10. sense_key=reduce%2:30:03:: | definition=to remove oxygen from a compound, or cause to react with hydrogen or form a hydride, or to undergo an increase in the number of electrons | synonyms=deoxidize, deoxidise
11. sense_key=reduce%2:30:01:: | definition=narrow or limit | synonyms=tighten | examples=reduce the influx of foreigners
12. sense_key=reduce%2:41:03:: | definition=put down by force or intimidation | synonyms=repress, quash, keep down, subdue, subjugate | examples=The government quashes any attempt of an uprising; China keeps down her dissidents very efficiently
13. sense_key=reduce%2:35:00:: | definition=undergo meiosis | examples=The cells reduce
14. sense_key=reduce%2:35:01:: | definition=reposition (a broken bone after surgery) back to its normal site
15. sense_key=reduce%2:30:12:: | definition=destress and thus weaken a sound when pronouncing it
16. sense_key=reduce%2:30:08:: | definition=reduce in scope while retaining essential elements | synonyms=abridge, foreshorten, abbreviate, shorten, cut, contract | examples=The manuscript must be shortened
17. sense_key=reduce%2:30:10:: | definition=be cooked until very little liquid is left | synonyms=boil down, decoct, concentrate | examples=The sauce should reduce to one cup
18. sense_key=reduce%2:30:02:: | definition=cook until very little liquid is left | synonyms=boil down, concentrate | examples=The cook reduced the sauce by boiling it for a long time
19. sense_key=reduce%2:30:09:: | definition=lessen the strength or flavor of a solution or mixture | synonyms=dilute, thin, thin out, cut | examples=cut bourbon
20. sense_key=reduce%2:29:00:: | definition=take off weight | synonyms=melt off, lose weight, slim, slenderize, thin, slim down

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

finish_reason: stop

role: assistant

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "reduced" in the given medical context.

Context: "Treatment should be delayed or discontinued, or the dose <t>reduced</t>, in patients whose blood counts are abnormal or who have certain other side effects."

The target is about reducing a dose (of medication). This means making the dose smaller or decreasing the amount.

Let me look at the candidate senses:

1. reduce%2:30:00:: - cut down on; make a reduction in - "reduce your daily fat intake" - This fits well with reducing a dose.
2. reduce%2:30:06:: - make less complex - doesn't fit
3. reduce%2:41:00:: - bring to humbler or weaker state - doesn't fit
4. reduce%2:40:04:: - simplify mathematical equation - doesn't fit
5. reduce%2:37:00:: - lower in grade or rank - doesn't fit
6. reduce%2:30:11:: - be the essential element - doesn't fit
7. reduce%2:30:05:: - reduce in size; reduce physically - "shrink" - This could fit too. A dose is being made smaller.
8. reduce%2:40:00:: - lessen and make more modest - "reduce one's standard of living" - This is about lifestyle/habits
9. reduce%2:30:04:: - make smaller; scale down - "reduce an image" - This could also fit
10. reduce%2:30:03:: - chemistry term - doesn't fit
11. reduce%2:30:01:: - narrow or limit - "reduce the influx of foreigners" - This is about limiting quantity
12. reduce%2:41:03:: - put down by force - doesn't fit
13. reduce%2:35:00:: - undergo meiosis - doesn't fit
14. reduce%2:35:01:: - reposition bone - doesn't fit
15. reduce%2:30:12:: - destress sound - doesn't fit
16. reduce%2:30:08:: - reduce in scope while retaining essential elements - "abridge" - doesn't fit
17. reduce%2:30:10:: - be cooked until liquid left - doesn't fit
18. reduce%2:30:02:: - cook until liquid left - doesn't fit
19. reduce%2:30:09:: - dilute - doesn't fit
20. reduce%2:29:00:: - lose weight - doesn't fit

The main candidates are 1, 7, 9, and possibly 8, 11.

Sense 1: "cut down on; make a reduction in" - synonyms: cut down, cut back, trim, trim down, trim back, cut. Examples: "reduce your daily fat intake". This is about decreasing the amount/quantity of something, especially consumption/intake.

Sense 7: "reduce in size; reduce physically" - synonyms: shrink. Examples: "Hot water will shrink the sweater; Can you shrink this image?" This is about physical size reduction.

Sense 9: "make smaller" - synonyms: scale down. Examples: "reduce an image". This is about making dimensions smaller.

For a medication dose, sense 1 seems most appropriate. Doses are measured in quantities (mg), and reducing a dose means decreasing the amount administered. The example "reduce your daily fat intake" is very similar semantically to "reduce the dose" - both are about decreasing the quantity of something that is consumed/administered.

Sense 7 is about physical size (shrink). Sense 9 is about making smaller (scale down an image). A dose isn't really about physical size or scaling dimensions.

Sense 1 with "cut down on; make a reduction in" is the best fit for reducing a dose of medication.

The answer should be a JSON object: {"sense_index": 1}

format: unknown

native_finish_reason: stop

provider: Novita

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in <t>patients</t> whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need choose sense index 1 or 2. Target patients in sentence "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects." It refers to people receiving medical care. So patient%1:18:00:: definition person requiring medical care, example emergency patients. Sense index is 1. Return JSON.

provider: Ambient


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: blood_count
Target surface form: blood counts
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose <t>blood counts</t> are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=blood_count%1:23:00:: | definition=the number of red and white corpuscles in a blood sample
2. sense_key=blood_count%1:04:00:: | definition=the act of estimating the number of red and white corpuscles in a blood sample

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer with JSON like {"sense_index": 3}. Need choose between 2 senses. Context: "patients whose blood counts are abnormal". Here blood counts refers to the numbers/results of blood cell counts, not the act of estimating. So sense 1. Need return index 1. Ensure only JSON object exactly like {"sense_index": 1}.

provider: Moonshot AI


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: abnormal
Target surface form: abnormal
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are <t>abnormal</t> or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=abnormal%3:00:00:: | definition=not normal; not typical or usual or regular or conforming to a norm | synonyms=unnatural | examples=abnormal powers of concentration; abnormal amounts of rain
2. sense_key=abnormal%3:00:03:: | definition=departing from the normal in e.g. intelligence and development | examples=they were heartbroken when they learned their child was abnormal; an abnormal personality
3. sense_key=abnormal%5:00:00:immoderate:00 | definition=much greater than the normal | examples=abnormal profits; abnormal ambition

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to choose the best WordNet sense for "abnormal" in the given context. Let me analyze the context carefully.

The context is about Alimta, a chemotherapy drug. The specific sentence is: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are <t>abnormal</t> or who have certain other side effects."

So here "abnormal" refers to blood counts that are not within the normal range - blood test results that deviate from what is considered normal/healthy.

Let me look at the three candidate senses:

1. abnormal%3:00:00:: - "not normal; not typical or usual or regular or conforming to a norm" | synonyms=unnatural | examples=abnormal powers of concentration; abnormal amounts of rain
2. abnormal%3:00:03:: - "departing from the normal in e.g. intelligence and development" | examples=they were heartbroken when they learned their child was abnormal; an abnormal personality
3. abnormal%5:00:00:immoderate:00 - "much greater than the normal" | examples=abnormal profits; abnormal ambition

In the medical context, "abnormal blood counts" means blood counts that deviate from the normal/expected range. This could be either too high or too low.

Sense 1 is the broadest and most general sense - "not normal; not typical or usual or regular or conforming to a norm." This fits perfectly with medical blood counts that are outside the normal range.

Sense 2 specifically refers to intelligence and development (e.g., a child being abnormal, abnormal personality). This doesn't fit blood counts.

Sense 3 means "much greater than the normal" - this is specifically about quantities that are excessive. But abnormal blood counts in chemotherapy context could be either too high OR too low (e.g., low white blood cell count, low platelets). So sense 3 is too specific and doesn't capture the bidirectional deviation.

Therefore, sense 1 is the best fit. The blood counts are "not normal" or "not conforming to a norm" - they fall outside the normal reference range.

The answer should be a JSON object: {"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: have
Target surface form: have
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who <t>have</t> certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=have%2:40:00:: | definition=have or possess, either in a concrete or an abstract sense | synonyms=have got, hold | examples=She has $1,000 in the bank; He has got two beautiful daughters
2. sense_key=have%2:42:00:: | definition=have as a feature | synonyms=feature | examples=This restaurant features the most famous chefs in France
3. sense_key=have%2:39:06:: | definition=go through (mental or physical states or experiences) | synonyms=experience, receive, get | examples=get an idea; experience vertigo
4. sense_key=have%2:40:04:: | definition=have ownership or possession of | synonyms=own, possess | examples=He owns three houses in Florida; How many cars does she have?
5. sense_key=have%2:30:00:: | definition=cause to move; cause to be in a certain position or condition | synonyms=get, let | examples=He got his squad on the ball; This let me in for a big surprise
6. sense_key=have%2:34:00:: | definition=serve oneself to, or consume regularly | synonyms=consume, ingest, take in, take | examples=Have another bowl of chicken soup!; I don't take sugar in my coffee
7. sense_key=have%2:41:00:: | definition=have a personal or business relationship with someone | examples=have a postdoc; have an assistant
8. sense_key=have%2:36:00:: | definition=organize or be responsible for | synonyms=hold, throw, make, give | examples=hold a reception; have, throw, or make a party
9. sense_key=have%2:40:01:: | definition=have left | examples=I have two years left; I don't have any money left
10. sense_key=have%2:42:12:: | definition=be confronted with | examples=What do we have here?; Now we have a fine mess
11. sense_key=have%2:30:01:: | definition=undergo | synonyms=experience | examples=The stocks had a fast run-up
12. sense_key=have%2:29:02:: | definition=suffer from; be ill with | examples=She has arthritis
13. sense_key=have%2:32:00:: | definition=cause to do; cause to act in a specified manner | synonyms=induce, stimulate, cause, get, make | examples=The ads induced me to buy a VCR; My children finally got me to buy a computer
14. sense_key=have%2:40:05:: | definition=receive willingly something given or offered | synonyms=accept, take | examples=The only girl who would have him was the miller's daughter; I won't have this dog in my house!
15. sense_key=have%2:40:03:: | definition=get something; come into possession of | synonyms=receive | examples=receive payment; receive a gift
16. sense_key=have%2:29:05:: | definition=undergo (as of injuries and illnesses) | synonyms=suffer, sustain, get | examples=She suffered a fracture in the accident; He had an insulin shock after eating three candy bars
17. sense_key=have%2:40:02:: | definition=achieve a point or goal | synonyms=get, make | examples=Nicklaus had a 70; The Brazilian team got 4 goals
18. sense_key=have%2:29:00:: | definition=cause to be born | synonyms=give birth, deliver, bear, birth | examples=My wife had twins yesterday!
19. sense_key=have%2:35:00:: | definition=have sex with; archaic use | synonyms=take | examples=He had taken this woman when she was most vulnerable

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 We need answer with JSON. Need disambiguate 'have' in sentence: "...in patients whose blood counts are abnormal or who have certain other side effects." Context medical. It means patients experience/suffer from/undergo certain other side effects. Candidate senses: sense 3 have%2:39:06 go through mental or physical states or experiences synonyms experience, receive, get examples get an idea; experience vertigo. Sense 11 have%2:30:01 undergo synonyms experience examples stocks had a fast run-up. Sense 12 have%2:29:02 suffer from; be ill with examples She has arthritis. Sense 16 have%2:29:05 undergo injuries and illnesses synonyms suffer, sustain, get examples She suffered a fracture; He had an insulin shock after eating three candy bars.

Our phrase "have certain other side effects". Side effects are adverse effects experienced/undergone by patients. Which WordNet sense is best? Let's analyze WordNet senses of 'have'. have%2:29:05: undergo (as of injuries and illnesses). This covers 'He had an insulin shock'. Side effects are akin to injuries/illnesses/physical adverse experiences. But sense 3 is go through (mental or physical states or experiences), example experience vertigo. Side effects are physical states/experiences. sense 12 suffer from; be ill with, e.g. She has arthritis. "have side effects" could mean suffer from side effects. But side effects are not illnesses, though adverse effects.

WordNet semantic distinction often uses 'have' for illnesses under sense 29:05. Let's check: WN entries. have.v.05: undergo (as of injuries and illnesses); "She suffered a fracture in the accident"; "He had an insulin shock after eating three candy bars". Mappings maybe synset have%2:29:05? Actually sense key format have%2:29:05:: maybe synset offset? Lexicographer file is verb.body. have%2:29:02 suffer from; be ill with. "She has arthritis". have%2:39:06: go through (mental or physical states or experiences); "get an idea"; "experience vertigo".

"have side effects" = be subject to side effects. Could be "undergo (as of injuries and illnesses)" due to 'side effects' being adverse physical conditions. Or "go through (mental or physical states or experiences)" due to states/experiences. Need choose best fine-grained. Let's consider examples: 'side effects' are effects (states) experienced by patient. In medical labeling, standard: "patients who have certain other side effects" means "experience/undergo". WordNet sense 'have%2:29:05' has gloss 'undergo (as of injuries and illnesses)' and synonyms suffer, sustain, get. It includes the example "He had an insulin shock after eating three candy bars". Side effects are injuries/illnesses-like. 'have%2:39:06' includes 'get an idea; experience vertigo'—more general. Gloss: go through (mental or physical states or experiences). It includes 'She has $1,000'? No.

We need consider schema: "have certain other side effects" not possess abstract. The patient is not possessing side effects; they are undergoing/experiencing them. The distinction between 3 and 16: 3 is general 'go through mental or physical states or experiences'; 16 is specifically undergo injuries and illnesses. "side effects" is an adverse reaction (type of illness/injury), so 16 likely best. But if side effects are not necessarily injuries, yet in medical context they are. Let's inspect other candidates: sense 11 'undergo' examples 'The stocks had a fast run-up'—that's not for living subjects. So not 11. Sense 12 'suffer from; be ill with' examples arthritis. Side effects are not a disease. Could be close. Sense 16 includes 'suffer, sustain, get' for injuries and illnesses; 'side effects' are not injuries nor illnesses, but maybe count as medical adverse events. Which WordNet sense would a WSD corpus annotate? Look at examples for 'have side effects': The patient had side effects. In WordNet, the sample "He had an insulin shock after eating three candy bars" is adverse medical event, not exactly illness/injury, but close. "side effects" are effects of a drug, maybe "undergo" sense. Another candidate 'suffer from; be ill with' (12) examples are chronic conditions. Not side effects.

Potential issue: sense key order: have%2:29:05 in candidate list is index 16. The instruction wants single best indexed sense, output JSON {"sense_index": 16}. Need ensure no hedging.

Let me re-evaluate thoroughly to avoid error.

Context: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects." 'have' with side effects. In dictionaries, 'have a side effect' = experience or suffer from a side effect. Macmillan: HAVE (experiencing): if you have a particular illness, you are suffering from it. "Have you had any side effects?" Often under same sense. WordNet separates:
- have.v.02 (have%2:40:04?) no. Let's enumerate actual senses maybe not exactly list.

Given candidate definitions:
1. have/possess concrete/abstract. Not.
2. have as feature. Not.
3. go through mental or physical states/experiences. Examples get an idea, experience vertigo.
4. own/possess. Not.
5. cause to move/let. Not.
6. consume. Not.
7. relationship. Not.
8. organize. Not.
9. have left. Not.
10. be confronted with. Not.
11. undergo (general), examples stocks run-up.
12. suffer from; be ill with.
13. cause to do. Not.
14. accept/take. Not.
15. receive/get something. Not.
16. undergo (as of injuries and illnesses), examples insulin shock.
17. achieve point. Not.
18. give birth. Not.
19. sex. Not.

So best is among 3,12,16. Let's compare 12 vs 16. Gloss 12: "suffer from; be ill with" -> She has arthritis. Strictly requires illness, "side effects" are not illnesses but symptoms/conditions. Gloss 16: "undergo (as of injuries and illnesses)" broader, includes accidents, shocks, injuries. Examples include "fracture" (injury) and "insulin shock" (medical adverse event). Side effects are adverse medical conditions, akin to shock. Could use "undergo". Sense 3 "go through (mental or physical states or experiences)" examples "vertigo" (spinning sensation) is similar to side effect. But sense 3 synonyms include receive, get; examples "get an idea; experience vertigo." "Experience vertigo" is a side effect possibly, but synset maybe focusing on perception or mental/physical states. Side effects are exactly physical/mental states/experiences. Sense 3 could capture "have side effects". But WordNet mapping of 'side effect' maybe considered a 'physical state' not injury/illness. However list says 'go through (mental or physical states or experiences)' which fits side effects well: side effects are physical states/experiences. The question: "have certain other side effects" Could be interpreted as 'experience certain other side effects' not necessarily suffer/undergo an injury. Which sense is more appropriate? Let's compare definitions: sense 3 includes physical states or experiences; 'side effects' are effects/states. Sense 16 is specifically 'as of injuries and illnesses' and includes 'suffer, sustain'. A side effect is a result of treatment, often experienced as symptom. It can be considered an injury/illness? Not exactly. WordNet's 'side_effect' noun is separate: 'a secondary and usually adverse effect of a drug or therapy'. WSD of 'have' might map to sense 3 or 16. If there is corpus annotation for "have side effects" perhaps sense 16. Let's search memory? WordNet-annotated SemCor perhaps has "had" in "he had a headache" maybe sense have.v.02? Actually in WordNet original, sense for 'have a headache' is have.v.02? Let's check mental map: have is ambiguous. WordNet list includes:
have, have got, hold (have or possess)
have, feature (have as a feature)
experience, receive, get, have (go through mental or physical states)
own, have, possess
cause to move, get, have
consume, ingest, take, have
have (relationship)
hold, throw, make, give
have left
be confronted with
undergo
suffer from, be ill with
induce, stimulate, cause, make
accept, take
receive, have
suffer, sustain, get
get, make
give birth
take

In WordNet standard, sense keys: have%2:40:00 = possess? likely index 1. have%2:42:00 = feature. have%2:39:06 = experience/receive/get. have%2:40:04 = own/possess. have%2:30:00 = get/cause. have%2:34:00 = consume. have%2:41:00 = relation. have%2:36:00 = hold/throw/party. have%2:40:01 = have left. have%2:42:12 = confronted. have%2:30:01 = undergo (stocks). have%2:29:02 = suffer from/be ill with. have%2:32:00 = induce. have%2:40:05 = accept/take. have%2:40:03 = receive. have%2:29:05 = suffer/sustain/undergo injuries illnesses. have%2:40:02 = make score. have%2:29:00 = give birth. have%2:35:00 = sex.

Actually suspect standard ordering: sense 10 in WordNet 3.0 is "suffer from; be ill with" have%2:29:02? It might be lexicographic file order. But doesn't matter; we use provided indices.

Now "have certain side effects". In SemCor maybe sentences: "If these effects persist or worsen, notify your doctor." Not relevant.

Let's reason via semantic subcategorization. Direct object "certain other side effects" = plural count noun denoting adverse reactions. The verb 'have' here has a passive/experiencer subject 'patients'. It isn't stative possession exactly; 'patients have side effects' could be read as 'the side effects are present in the patients'. In English, 'have' with symptoms/diseases is polysemous: (a) possess ('John has blue eyes'), (b) experience/suffer from. WordNet draws line between possession and experience at sense 3 and 12/16. "have a headache/flu/side effect" typically maps to 'suffer from' or 'undergo' or 'experience'. 'suffer from; be ill with' is for diseases/conditions. 'undergo (as of injuries and illnesses)' for injuries and illnesses. 'side effect' is a condition, perhaps injury. "Go through mental or physical states or experiences" is broader.

But which candidate's examples best fit? Example sense 16 "He had an insulin shock after eating three candy bars." An insulin shock is an adverse medical event/effect, arguably a side effect (here from candy bars, but analogous to eating). Example sense 12 "She has arthritis." A chronic illness. Example sense 3 "experience vertigo." Vertigo could be a side effect! However, "side effects" as a phrase are medical adverse events caused by a drug, perhaps more like 'insulin shock' caused by eating candy bars (physiological reaction). Thus 16 seems closer.

Potential alternative: side effects are "effects" that a drug has on a patient; patient "has" side effects = experiences. In PropBank, have.03 is "have as experience"? frame? Not needed.

The instruction says fine-grained WSD, use context/examples/synonyms; choose single best. Do not answer sense key, just JSON index.

I think answer index 16. But let's double-check if "side effects" could be considered a feature? Sense 2: "have as a feature" synonyms feature. Example "This restaurant features the most famous chefs". Not. But in medical context, could it mean "the treatment has side effects"? Here subject is patients who have side effects, not Alimta.

Sense 10 "be confronted with" examples "What do we have here?" Could 'have side effects' mean 'be confronted with'? Not.

Sense 11 "undergo" general examples stocks run-up. Patients undergo side effects? Possibly but sense 11 general includes events not necessarily adverse medical. The gloss lacks medical domain. Example non-living subject. We prefer 16 for injury/illness.

Between 3 and 16, note gloss of 3: "go through (mental or physical states or experiences)". "Side effects" includes physical states and experiences; side effects are exactly experiences. Could be best. But WordNet examples include experience vertigo (a symptom). The phrase 'have side effects' often equivalent to 'experience side effects'. However 16 examples include insulin shock, fracture. Which is closer? Let's look at semantic relation: 'side effect' noun gloss: a secondary and usually adverse effect of a drug or therapy. An 'effect' is a state or event resulting from a cause. Undergoing an effect is general. But the specific frame 'undergo (as of injuries and illnesses)' maybe excludes effects? It's restricted to injuries and illnesses. Side effects are not primarily injuries or illnesses, but physiological conditions. So sense 3 might be broader and more appropriate for states/experiences. Hmm.

Question: 'certain other side effects' is predicate adjunct in a conditional: patients who have certain other side effects. This means they experience them. In WordNet, the 'suffer from; be ill with' sense is common for 'have an illness'. But 'side effect' isn't an illness. 'have' in 'have a headache' often maps to which sense? Let's infer from WordNet examples: The example "He had an insulin shock after eating three candy bars" uses have = undergo (as of injuries and illnesses). A headache is an illness? There is no example. But 'she has arthritis' = suffer from/be ill with. A headache is an illness? Could be. Side effects are physiological experiences maybe closer to 'undergo (as of injuries and illnesses)' than 'suffer from; be ill with'. sense 16 is best.

One more nuance: The target 'have' appears with plural object "side effects". The 'suffer from' sense often is used with diseases: "have arthritis". The 'undergo injuries/illnesses' sense often with events/conditions. Plural generic "side effects" would be "undergo".

I will answer 16. But before final, consider if they expect 3 due to 'experience' synonym. Let's read instructions: "WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge." It asks best indexed sense from list. We need output JSON. Good.

Let's maybe also consider if 'have' could mean 'experience' (sense 3) because example "experience vertigo" exactly a side effect. Sense 3 synonym 'experience' aligns with "patients experience side effects". Sense 16 synonym 'suffer, sustain, get' maybe too adversarial/injury oriented. But side effects are adverse, so 16 fits. Which is "best"? Let's evaluate definitions more precisely:
- 3: "go through (mental or physical states or experiences)". This is generic for any mental/physical state. Examples: "get an idea" (mental), "experience vertigo" (physical). If you have a side effect, you experience a physical state. Yes.
- 16: "undergo (as of injuries and illnesses)". This is specifically for injuries and illnesses. Side effects are drug-induced adverse effects, often medical conditions. Yes.

WordNet often has distinct synsets for 'undergo' (have.v.11) and 'suffer/sustain/get' (have.v.16). have.v.16 includes "undergo" as part of gloss? Wait gloss says "undergo (as of injuries and illnesses)", synonyms suffer, sustain, get. It is a subtype of undergo. have.v.11 "undergo" examples stocks. So have.v.16 is the one for adverse medical conditions. Side effects are adverse medical conditions caused by medication, so 16.

But could there be a WordNet mapping rule: If direct object is an illness/injury, use 16. If object is a symptom, maybe 12. 'Side effects' are not an illness but effects. Maybe 3. Let's search memory of glosses for 'experience' in WordNet: WordNet 3.0 verb experience: "go through" includes "experience vertigo". That is a symptom. A side effect is often a symptom. So sense 3 captures symptoms well. But have.v.16 also has 'insulin shock' example. Hmm.

Let's examine the exact WordNet brain: For 'have', sense 'experience, receive, get, have, undergo' maybe is sense 3? Actually there may be only one 'go through (mental or physical states)' sense vs 'undergo (as of injuries and illnesses)' with verb frame 'Somebody ----s something'. Both are subclasses of 'undergo'. Side effects are injuries? The gloss "as of injuries and illnesses" perhaps is triggered by noun 'side effect' which is a kind of 'disorder'? Actually side_effect hypernym might be 'effect/result', not injury. But drug adverse effects are classified as 'pathological state'? Not sure.

Decision parameters:
- If we choose 16, risk if the intended sense is 3 (more common for physical states).
- If we choose 3, risk if intended sense is 16 (since 'side effects' are adverse medical conditions).

Let's compare examples from candidates to context. The examples provided can be used. For sense 3 examples: 'get an idea; experience vertigo'. Vertigo as a side effect is indeed a physical state. For sense 16 examples: 'She suffered a fracture in the accident; He had an insulin shock after eating three candy bars'. The second is about physiological shock due to external cause (candy bars), similar to side effect due to drug. But 'insulin shock' is a medical condition, not an effect. Side effects are adverse effects, hence 'insulin shock' is an adverse effect (of low blood sugar). This is closer.

Also synonyms: sense 3 synonyms experience, receive, get. 'Patients receive side effects' not idiomatic; they experience side effects. Sense 16 synonyms suffer, sustain, get. 'Patients suffer side effects' is idiomatic. 'Sustain side effects'? 'Get side effects' yes (have side effects). So 16 synonyms map more idiomatically. 'Experience side effects' also idiomatic. But sense 3 includes experience. However sense 16 includes 'suffer' and 'sustain', and 'get' which aligns with 'have = get side effects'.

Given 'side effects' are specifically adverse, sense with gloss 'undergo (as of injuries and illnesses)' and synonyms suffer/sustain/get is best. Thus index 16.

One further check: Is there a possibility that 'have' in "patients whose blood counts are abnormal or who have certain other side effects" means 'possess' (have side effects as a feature/condition)? In a broad biomedical context, side effects are attributes of treatment, not possessions. So not 1/4. Thus 16.

Final JSON: {"sense_index": 16}. Ensure only JSON object returned, no additional text.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: certain
Target surface form: certain
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have <t>certain</t> other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=certain%5:00:00:definite:00 | definition=definite but not specified or identified | examples=set aside a certain sum each week; to a certain degree
2. sense_key=certain%3:00:02:: | definition=having or feeling no doubt or uncertainty; confident and assured | synonyms=sure | examples=felt certain of success; was sure (or certain) she had seen it
3. sense_key=certain%3:00:01:: | definition=established beyond doubt or question; definitely known | examples=what is certain is that every effect must have a cause; it is certain that they were on the bus
4. sense_key=certain%3:00:03:: | definition=certain to occur; destined or inevitable; ; ; - Benjamin Franklin | synonyms=sure | examples=he was certain to fail; his fate is certain
5. sense_key=certain%3:00:05:: | definition=established irrevocably | synonyms=sealed | examples=his fate is sealed
6. sense_key=certain%5:00:00:reliable:00 | definition=reliable in operation or effect | synonyms=sure | examples=a quick and certain remedy; a sure way to distinguish the two
7. sense_key=certain%5:00:00:careful:00 | definition=exercising or taking care great enough to bring assurance | synonyms=sure | examples=be certain to disconnect the iron when you are through; be sure to lock the doors

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer JSON only. Need choose best sense for "certain" in sentence: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have <t>certain</t> other side effects." Here "certain other side effects" means some particular but unspecified side effects. Candidate sense 1: definite but not specified or identified; examples "set aside a certain sum each week; to a certain degree". That fits. Sense 2 no doubt. Sense 3 established beyond doubt. Sense 4 certain to occur. Sense 5 sealed. Sense 6 reliable. Sense 7 careful. So best is sense 1. Need output JSON exactly {"sense_index": 1}. Ensure no extra text.

provider: Cloudflare


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: other
Target surface form: other
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain <t>other</t> side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=other%3:00:00:: | definition=not the same one or ones already mentioned or implied; - the White Queen | examples=today isn't any other day; the construction of highways and other public works
2. sense_key=other%5:00:00:past:00 | definition=recently past | examples=the other evening
3. sense_key=other%5:00:02:past:00 | definition=belonging to the distant past | synonyms=early, former | examples=the early inhabitants of Europe; former generations
4. sense_key=other%5:00:00:strange:00 | definition=very unusual; different in character or quality from the normal or expected; - Lance Morrow | examples=a strange, other dimension...where his powers seemed to fail

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We need output JSON only {"sense_index": N}. Need choose best sense for "other" in phrase "certain other side effects." Let's analyze.

WordNet senses:
1. other a not the same one or ones already mentioned or implied; examples today isn't any other day; construction of highways and other public works. This is the core determiner/adjective sense meaning additional/different from those mentioned. In "certain other side effects", other side effects refers to additional side effects besides the ones already mentioned/ implied. That's sense 1.
2. other a recently past (the other evening).
3. other a belonging to distant past (early/former). Not relevant.
4. other a strange. Not relevant.

Thus answer index 1. Need ensure JSON format exact, no extra text.

provider: DeepInfra


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: side_effect
Target surface form: side effects
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other <t>side effects</t>. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=side_effect%1:26:00:: | definition=a secondary and usually adverse effect of a drug or therapy | examples=severe headaches are one of the side effects of the drug
2. sense_key=side_effect%1:19:00:: | definition=any adverse and unwanted secondary effect | synonyms=fallout | examples=a strategy to contain the fallout from the accounting scandal

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 We need answer as JSON with sense_index. The task: choose single best indexed sense for target word "side effects" in context. Two candidates:
1. side_effect%1:26:00:: definition secondary and usually adverse effect of a drug or therapy.
2. side_effect%1:19:00:: any adverse and unwanted secondary effect; synonyms=fallout; examples contain fallout from scandal.
Context is about Alimta, anticancer chemotherapy drug. It mentions side effects of treatment, severe kidney problems etc. The phrase is used in pharmacological context. Therefore sense 1 is best.
We need return only JSON object exactly like {"sense_index": 3}. Index is presumably candidate list numbering: sense 1. So {"sense_index": 1}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: use
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for <t>use</t> in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=use%1:04:00:: | definition=the act of using | synonyms=usage, utilization, utilisation, employment, exercise | examples=he warned against the use of narcotic drugs; skilled in the utilization of computers
2. sense_key=use%1:07:00:: | definition=what something is used for | synonyms=function, purpose, role | examples=the function of an auger is to bore holes; ballet is beautiful but what use is it?
3. sense_key=use%1:07:02:: | definition=a particular service | examples=he put his knowledge to good use; patrons have their uses
4. sense_key=use%1:22:00:: | definition=(economics) the utilization of economic goods to satisfy needs or in manufacturing | synonyms=consumption, economic consumption, usance, use of goods and services | examples=the consumption of energy has increased steadily
5. sense_key=use%1:04:01:: | definition=(psychology) an automatic pattern of behavior in reaction to a specific situation; may be inherited or acquired through frequent repetition | synonyms=habit | examples=owls have nocturnal habits; she had a habit twirling the ends of her hair
6. sense_key=use%1:04:02:: | definition=exerting shrewd or devious influence especially for one's own advantage | synonyms=manipulation | examples=his manipulation of his friends was scandalous
7. sense_key=use%1:07:03:: | definition=(law) the exercise of the legal right to enjoy the benefits of owning property | synonyms=enjoyment | examples=we were given the use of his boat

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer with JSON only. Need choose best sense for "use" in sentence: "Alimta is not recommended for <t>use</t> in patients with moderate or severe kidney problems." This is nominal use. The phrase "for use in patients" means the act of using/administering the drug in those patients. Candidate sense 1: the act of using; synonyms usage, utilization, employment, exercise; examples "use of narcotic drugs". This fits: not recommended for the act of using in patients with kidney problems. Sense 2: what something is used for (function, purpose). "for use in patients" could be purpose? But "not recommended for use in patients" means not recommended to be used/administered. Sense 1 is best. Need output JSON {"sense_index": 1}. Ensure no extra text.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in <t>patients</t> with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need choose single best indexed sense for target 'patients' in context. Candidate sense 1: person requires medical care, examples emergency patients. Candidate sense 2: semantic role patient role in linguistics. The context clearly patients receiving drug, kidney problems, medical persons. So sense index 1. Output JSON exactly.

provider: Together


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: moderate
Target surface form: moderate
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with <t>moderate</t> or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=moderate%3:00:00:: | definition=being within reasonable or average limits; not excessive or extreme | examples=moderate prices; a moderate income
2. sense_key=moderate%5:00:00:mild:00 | definition=not extreme | synonyms=temperate | examples=a moderate penalty; temperate in his response to criticism
3. sense_key=moderate%5:00:00:temperate:00 | definition=marked by avoidance of extravagance or extremes | synonyms=restrained | examples=moderate in his demands; restrained in his response

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We need choose single best sense for target "moderate" in phrase "moderate or severe kidney problems". Candidate senses:
1 moderate%3:00:00:: adj "being within reasonable or average limits; not excessive or extreme" examples moderate prices, moderate income.
2 moderate%5:00:00:mild:00 adj "not extreme" synonyms temperate examples a moderate penalty; temperate in his response to criticism.
3 moderate%5:00:00:temperate:00 adj "marked by avoidance of extravagance or extremes" synonyms restrained examples moderate in his demands; restrained in his response.

We need WSD. Medical context: moderate kidney problems means intermediate severity, not mild, not severe, within reasonable/average limits of abnormality? Let's analyze WordNet senses. The first is 3:00:00 moderate (all adjective core senses?) Actually WordNet adj senses. The definition "being within reasonable or average limits; not excessive or extreme" is likely the most common sense for "moderate" as in moderate temperature, moderate amount. The second sense "not extreme" under mild, with synonym temperate, example "a moderate penalty". Third sense "marked by avoidance of extravagance or extremes" under temperate, about people behavior, restraint. In medical severity grading: "moderate kidney problems" denotes degree/severity: within reasonable/average limits? It means neither mild nor severe, an intermediate level. Sense 1 seems best: being within reasonable or average limits; not excessive or extreme. It covers moderate severity. Sense 2 is a satellite of mild? Actually %5:00:00:mild:00 is satellite adjective: not extreme; examples moderate penalty. Could also fit severity. But example "a moderate penalty" is similar to moderate problems. However kidney problems as a condition are not "mild"; moderate is more like between mild and severe. In WordNet, "mild" definition? mild%3:00:00:: moderate in type or degree or effect or force; far from extreme. So moderate as satellite of mild: not extreme. Sense 1 is a central adjective: within reasonable or average limits; not excessive or extreme. Which best fits "moderate kidney problems"? I think sense 1 (index 1). Need output JSON {"sense_index": 1}. Also instructions: Return only JSON object exactly like {"sense_index": 3}. No explanation. We must be careful not to include WordNet sense key.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: severe
Target surface form: severe
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or <t>severe</t> kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=severe%5:00:00:intense:00 | definition=intensely or extremely bad or unpleasant in degree or quality | synonyms=terrible, wicked | examples=severe pain; a severe case of flu
2. sense_key=severe%5:00:00:strong:00 | definition=very strong or vigorous | synonyms=hard, knockout | examples=strong winds; a hard left to the chin
3. sense_key=severe%5:00:00:plain:01 | definition=severely simple | synonyms=austere, stark, stern | examples=a stark interior
4. sense_key=severe%5:00:02:nonindulgent:00 | definition=unsparing and uncompromising in discipline or judgment; - H.G.Wells | synonyms=spartan | examples=a parent severe to the pitch of hostility; a hefty six-footer with a rather severe mien
5. sense_key=severe%5:00:00:critical:03 | definition=causing fear or anxiety by threatening great harm | synonyms=dangerous, grave, grievous, serious, life-threatening | examples=a dangerous operation; a grave situation
6. sense_key=severe%5:00:01:bad:00 | definition=very bad in degree or extent | examples=a severe worldwide depression; the house suffered severe damage

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We need choose best sense index for "severe" in context: "moderate or severe kidney problems". It's about medical severity of disease/condition. Candidates:

1 intense/extremely bad unpleasant: severe pain, severe case of flu. Could fit kidney problems as severe case? But sense 1 examples are about pain, flu. Synonyms terrible, wicked. It emphasizes intensely bad/unpleasant.
2 strong/vigorous: winds. Not fit.
3 plain/simple: interior. No.
4 nonindulgent: parent severe. No.
5 critical: causing fear/anxiety by threatening great harm; dangerous, grave, serious, life-threatening. "severe kidney problems" could be serious but not necessarily life-threatening.
6 very bad in degree or extent: severe worldwide depression; severe damage. "severe kidney problems" fits sense 6: degree/extent of bad condition.

Need pick single best. WordNet sense severe%5:00:01:bad:00 definition "very bad in degree or extent". Medical severity often maps to this sense? Let's think. WSD datasets? In WordNet, severe has adjective senses. For "severe kidney problems" likely annotated as sense 1? Let's examine glosses. Sense 1: "intensely or extremely bad or unpleasant in degree or quality" (terrible, wicked) - severe pain; a severe case of flu. Sense 6: "very bad in degree or extent" - severe worldwide depression; house suffered severe damage. The phrase "kidney problems" is a condition; moderate or severe categorizes severity. Both 1 and 6 are close. Which is best?

Distinguish: sense 1 is "intensely or extremely bad or unpleasant in degree or quality". It often modifies pain, case of flu (illness). Sense 6 is "very bad in degree or extent", often used for damage, depression. For "kidney problems", a medical condition, sense 1 maybe because "severe case of flu" similar to severe kidney problems. But sense 6 also possible.

Need not hedge. Let's evaluate. WordNet definitions:
severe%5:00:00:intense:00 = intensely or extremely bad or unpleasant in degree or quality. Synonyms: terrible, wicked. Examples: severe pain; a severe case of flu.
severe%5:00:01:bad:00 = very bad in degree or extent. Examples: a severe worldwide depression; the house suffered severe damage.

The context: "patients with moderate or severe kidney problems". This is a common phrasing in EPAR (European public assessment report). "Severe renal impairment" would map to which WordNet sense? WSD sense might be "severe%5:00:00:intense:00"? Hmm. "Severe" applied to illness severity often maps to sense 1 (intensely/extremely bad in degree or quality) or sense 5 (critical/grave). But "kidney problems" not necessarily critical/life-threatening; the text says Alimta not recommended. It's about degree of impairment.

Look at sense 5: causing fear or anxiety by threatening great harm; dangerous, grave, grievous, serious, life-threatening. In medical context "severe" often is synonymous with "serious". However "severe kidney problems" means advanced renal dysfunction; could be serious. But synonyms include dangerous, grave, life-threatening; "kidney problems" might be chronic, not acute danger.

In WordNet, sense 5 is "causing fear or anxiety by threatening great harm" - severe illness could be "a severe case of flu" maybe? No, sense 5 examples: dangerous operation, grave situation.

We should choose the most typical WordNet sense for "severe" with "kidney problems". I think sense 1 is the best because "severe" is used to describe the degree/quality of a medical condition; examples include "severe case of flu". But note sense 6 also can describe a condition ("severe worldwide depression"). However "kidney problems" is more akin to "case of flu" than "damage/depression".

Let's search memory: WordNet sense of "severe" in sentences like "severe arthritis" often annotated as "severe%5:00:00:intense:00"? Possibly. In SemCor? "severe economic problems" might be sense 6. "severe kidney problems" could be sense 6 due to "problems" (bad situation). Hmm.

The instruction says WordNet glosses are schematic; use context, synonyms, examples. "Moderate or severe kidney problems" is about severity levels of kidney impairment. Synonyms terrible/wicked (sense1) vs very bad (sense6). "Severe kidney problems" means very bad kidney problems. Both definitions fit. Examples: severe pain; a severe case of flu (sense1) vs a severe worldwide depression; severe damage (sense6). A medical condition "kidney problems" aligns with "case of flu" (illness) more than "depression/damage". So I'd choose index 1.

But I need be careful: The sense keys include 'severe%5:00:00:intense:00' and 'severe%5:00:01:bad:00'. The first is grouped under 'intense' (intensely or extremely bad or unpleasant in degree or quality), second under 'bad' (very bad in degree or extent).

For "severe kidney problems", the natural interpretation: "kidney problems" are bad; severe means very bad in degree/extent. The phrase is similar to "severe damage" or "severe depression". But "case of flu" is a disease too. Hmm.

Let's consider how WordNet distinguishes sense 1 and 6. Sense 1: intensely or extremely bad or unpleasant in degree or quality. It is often used for sensations (pain) and cases of disease where unpleasantness matters. Sense 6: very bad in degree or extent, used for events/situations/damage. "Kidney problems" are a medical condition/impairment; severity classification in medicine is about extent of organ dysfunction. Example "severe renal impairment" maps to "very bad in degree or extent" = sense 6 perhaps.

If we search annotated corpora? I recall WordNet 3.0 "severe" sense 2? Let's not rely. Let's reason from gloss examples. Sense 1 examples: severe pain; a severe case of flu. Pain is a subjective sensation; flu case is illness severity. Sense 6 examples: a severe worldwide depression; the house suffered severe damage. These are objective extents of bad conditions. "Kidney problems" are objective medical conditions. However, "case of flu" is also objective.

The phrase "moderate or severe kidney problems" is a standard contraindication phrase. "Severe" here modifies "kidney problems". If replaced synonyms: "terrible kidney problems" (sense1) vs "very bad kidney problems" (sense6). Both natural. But "terrible" has nuance of unpleasantness/awfulness; "very bad" is more neutral. Medical text likely uses "severe" as "very bad in degree" rather than "intensely unpleasant".

Also sense 1 synonym "wicked" is informal and not medical. Sense 6 no synonyms listed except itself. It may be the best match.

What about sense 5? Synonyms dangerous, grave, grievous, serious, life-threatening. In medicine, "severe kidney problems" could be serious. But "causing fear or anxiety by threatening great harm" is stronger and includes danger. The sentence is not about immediate threat but contraindication due to severity.

I lean sense 6. But uncertain. Let's see if any other clues: "moderate or severe" pairs moderate with severe. Moderate means average/limited degree; severe means very bad in degree or extent. In medical grading, mild/moderate/severe corresponds to degree/extent. So sense 6.

However, in WordNet, sense 1 is defined as "intensely or extremely bad or unpleasant in degree or quality". The phrase "moderate or severe" relates to degree/quality. "Severe pain" is degree. "Severe case of flu" is degree. Sense 1 includes "in degree or quality". Sense 6 includes "in degree or extent". Both mention degree.

The distinction may be that sense 1 is used with things that can be unpleasant, while sense 6 with things that are bad in extent. "Kidney problems" are unpleasant? Maybe. But the sentence is clinical and not about patient experience.

Let's examine candidate order. They are listed 1-6. The user wants JSON {"sense_index": ?}. We should choose one. I think the intended answer likely is 1 because "severe kidney problems" is an illness condition analogous to "severe case of flu". But many WSD tasks? Let's explore.

Consider WordNet's adjective cluster: severe (senses):
- (intense) terrible, wicked (severe pain; severe case of flu)
- (strong) hard, knockout (severe weather?)
- (plain) austere
- (nonindulgent) spartan
- (critical) dangerous, grave, grievous, serious, life-threatening
- (bad) very bad in degree or extent

WordNet may tag "severe" in "severe kidney problems" as sense "bad"? If you look at definitions, "severe" in medical context like "severe illness" often maps to sense 1? Actually WordNet's sense 5 synonyms include "serious" and "grave", which are common in medical severity. But "severe kidney problems" not life-threatening per se.

Let's maybe do a mental search: In WSD dataset "SensEval-3 lexical sample" includes "severe"? I don't recall. In "SemCor", "severe" occurrences: "severe drought" likely sense 6; "severe depression" sense 6; "severe case of polio" maybe sense 1? "severe burns" maybe sense 1? Hmm.

The phrase "kidney problems" is a condition; "moderate or severe" in drug label. I think annotators would pick sense 1 if they think of medical condition (like flu). But sense 5? It includes "serious". In drug labels, "severe renal impairment" is a serious condition. But "severe" there is not "causing fear" but a severity grade.

Let's parse the exact definition of sense 5: "causing fear or anxiety by threatening great harm". That implies the thing itself causes fear (a dangerous operation, a grave situation). "Severe kidney problems" may cause anxiety but it's not the focus.

Definition of sense 6: "very bad in degree or extent". This is generic. Since "kidney problems" are bad, severe means very bad degree. This seems the most straightforward.

But the instruction says "use the sentence context, the examples, and the synonyms". Synonyms for sense 6 not given, examples are economic depression and house damage. Synonyms for sense 1: terrible, wicked; examples: severe pain; a severe case of flu. The examples for sense 1 are closer to a medical condition. Yet "kidney problems" are not "pain" but are a disease. "Case of flu" is a disease. So sense 1 examples are closer.

The phrase "severe kidney problems" can be paraphrased as "terrible kidney problems"? That sounds slightly more colloquial, but acceptable. "Wicked kidney problems" not. "Very bad kidney problems" also acceptable.

WordNet's sense 1 is for "intensely or extremely bad or unpleasant in degree or quality". It is likely the default for "severe" before "illness" because of "severe case of flu". I'd choose sense 1. But is there a possibility the expected answer is 6 because "problems" are bad situations like depression?

Let's examine examples:
- sense 1 examples: severe pain; a severe case of flu
- sense 6 examples: a severe worldwide depression; the house suffered severe damage

"Kidney problems" as a medical condition is more like "case of flu" than "worldwide depression" or "house damage". So sense 1. Also "moderate or severe" in medicine uses severe to mean intense degree of disease, same as "severe case of flu".

Could sense 5 be better because it has synonym "serious"? Example "a grave situation". "Severe kidney problems" are a serious situation. But the word "severe" itself is in definition 5 as a synonym? Actually sense 5 synonyms are dangerous, grave, grievous, serious, life-threatening; no severe. It means "causing fear or anxiety by threatening great harm". The medical condition could be serious, but the phrase is about severity not imminent harm. So not best.

Thus answer: {"sense_index": 1}. Need only JSON.

Double-check: The user explicitly says do not answer with a WordNet sense key. Return only JSON exactly like {"sense_index": 3}. So final must be only JSON. No explanation. Ensure no markdown? It says return only a JSON object exactly like. We can output raw JSON.

Choose index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: problem
Target surface form: problems
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney <t>problems</t>. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=problem%1:26:00:: | definition=a state of difficulty that needs to be resolved | synonyms=job | examples=she and her husband are having problems; it is always a job to contact him
2. sense_key=problem%1:10:00:: | definition=a question raised for consideration or solution | examples=our homework consisted of ten problems to solve
3. sense_key=problem%1:09:00:: | definition=a source of difficulty | synonyms=trouble | examples=one trouble after another delayed the job; what's the problem?

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need produce final JSON object exactly {"sense_index": 3}. Need no extra text.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: more
Target surface form: more
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For <t>more</t> information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=more%3:00:01:: | definition=(comparative of `much' used with mass nouns) a quantifier meaning greater in size or amount or extent or degree | synonyms=more than | examples=more land; more support
2. sense_key=more%3:00:02:: | definition=(comparative of `many' used with count nouns) quantifier meaning greater in number | examples=a hall with more seats; we have no more bananas

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer. User wants choose best sense for "more" in phrase "For more information, see...". Context. Candidate senses: 1. quantifier with mass nouns comparative of much; 2. comparative of many count nouns. In "more information", information is mass noun; sense1 applies: greater in amount. Need output JSON {"sense_index":1}. Ensure only JSON, no hedging. As assistant.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: information
Target surface form: information
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more <t>information</t>, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=information%1:10:00:: | definition=a message received and understood | synonyms=info
2. sense_key=information%1:09:00:: | definition=knowledge acquired through study or experience or instruction
3. sense_key=information%1:10:02:: | definition=formal accusation of a crime
4. sense_key=information%1:14:00:: | definition=a collection of facts from which conclusions may be drawn | synonyms=data | examples=statistical data
5. sense_key=information%1:07:00:: | definition=(communication theory) a numerical measure of the uncertainty of an outcome | synonyms=selective information, entropy | examples=the signal contained thousands of bits of information

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We need respond with JSON only, choose best sense. Let's analyze.

Target: information in sentence "For more <t>information</t>, see the Summary of Product Characteristics (also part of the EPAR)." Context is medication instructions; asks for more info, see a document. Candidate senses:
1. message received and understood, synonyms info. This fits "for more information" = more details/messages about product. In WordNet, information%1:10:00:: is communication noun (message).
2. knowledge acquired through study or experience or instruction. Not quite in this formulaic phrase "for more information"; the SPC is a source of detailed information as messages/data.
3. formal accusation of crime: no.
4. collection of facts from which conclusions may be drawn (data). Could fit but "for more information" common with sense 1.
5. comm theory entropy: no.

Need single best. Usually "for more information" maps to sense 1 "a message received and understood" or perhaps sense 2? Let's think about WordNet divisions. sense 1:10:00 is communication, info. sense 1:09:00 is cognition, knowledge. sense 1:14:00 group, data. The phrase "more information" could refer to additional knowledge, but in a directive to see a document, it's additional content/messages. WordNet examples? Let's recall WordNet for "information":
- noun.communication: information, info (#1) a message received and understood; syn info.
- noun.cognition: information (#2) knowledge acquired through study or experience or instruction.
- noun.communication: information (#3) formal accusation of a crime made by a grand jury.
- noun.group: information (#4) a collection of facts from which conclusions may be drawn; syn data.
- noun.attribute: information (#5) entropy.

Which is the default sense? In SemCor etc, "information" in "for more information" often tagged as communication sense 1. Example "For more information, contact..." Let's choose sense_index: 1 (since candidate senses listed with index 1). Return JSON exactly.

We must not hedge. Only JSON.