[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
If you want more information on the basis of the CHMP recommendations, read the Scientific Discussion (also part of the EPAR). What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of <t>cancer</t>: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to identify the best WordNet sense for "cancer" in the provided context.

Context analysis: The text is about Alimta, a medicine used to treat two types of cancer. It mentions pleural mesothelioma (cancer of the lining of the lungs) and advanced/metastatic non-small cell lung cancer. This is clearly the medical disease sense of "cancer."

Looking at the candidate senses:
1. cancer%1:26:00:: - any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread... synonyms=malignant neoplastic disease
2. cancer%1:18:00:: - astrological person born while sun is in Cancer
3. cancer%1:17:00:: - small zodiacal constellation
4. cancer%1:15:00:: - fourth sign of zodiac
5. cancer%1:05:00:: - type genus of family Cancridae (crabs)

The context is clearly about malignant neoplastic disease, which is sense 1. The form is "cancer" in the phrase "two types of cancer" and "treat ... cancer" - all medical usage.

I need to return only {"sense_index": 1}. I should not include the sense key in my answer.

The instruction says return exactly like {"sense_index": 3} — meaning the exact JSON format with the index number for the selected sense.

So my answer should be: {"sense_index": 1}

I should only return thisJSON object.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
If you want more information on the basis of the CHMP recommendations, read the Scientific Discussion (also part of the EPAR). What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (<t>cancer</t> of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

finish_reason: stop

role: assistant

reasoning_content: We need choose best WordNet sense for "cancer" given context. Context is medical about cancer types. Candidate 1 definition any malignant growth... Candidate 2 astrological person, 3 constellation, 4 zodiac sign, 5 genus crab. Clearly medical sense. The target appears in "two types of cancer: pleural mesothelioma (cancer of the lining...)" and "medicines for cancer". Sense 1 matches. Must output JSON exact {"sense_index": 1}. Ensure no extra text.

format: unknown

native_finish_reason: stop

provider: Ambient

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: lining
Target surface form: lining
Context:
If you want more information on the basis of the CHMP recommendations, read the Scientific Discussion (also part of the EPAR). What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the <t>lining</t> of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells.

Candidate senses:
1. sense_key=lining%1:06:00:: | definition=a protective covering that protects an inside surface | synonyms=liner
2. sense_key=lining%1:06:01:: | definition=a piece of cloth that is used as the inside surface of a garment | synonyms=liner
3. sense_key=lining%1:04:01:: | definition=providing something with a surface of a different material | synonyms=facing
4. sense_key=lining%1:04:00:: | definition=the act of attaching an inside lining (to a garment or curtain etc.)

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 The user asks me to choose the single best indexed sense for target lemma "lining" in the given context. This is a WordNet sense disambiguation task. I need to select one of four candidate senses, return JSON like {"sense_index": 3}. Do not answer with a WordNet sense key, only JSON.

Context: "pleural mesothelioma (cancer of the <t>lining</t> of the lungs that is usually caused by exposure to asbestos)". This is the biological lining of an organ: a protective covering that protects an inside surface. Among candidates:

1. lining%1:06:00:: definition="a protective covering that protects an inside surface" synonyms=liner. This matches anatomical/biological lining. In WordNet, sense 1:06:00 maybe noun.artifact? Actually lining as protective covering. The "lining of the lungs" = the inner surface protective covering of organ.

2. piece of cloth inside garment. Not relevant.

3. providing something with a surface of different material (facing). A lining of a garment can be seen as facing. Not this context.

4. act of attaching inside lining. Not relevant.

So best sense is index 1. The "candidate senses" list indices 1-4. Index 1. Need output {"sense_index": 1}. Ensure exactly JSON. No additional explanation. The user instructs return only JSON object. So final should be just JSON.

provider: Parasail


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cause
Target surface form: caused
Context:
If you want more information on the basis of the CHMP recommendations, read the Scientific Discussion (also part of the EPAR). What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually <t>caused</t> by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells.

Candidate senses:
1. sense_key=cause%2:36:00:: | definition=give rise to; cause to happen or occur, not always intentionally | synonyms=do, make | examples=cause a commotion; make a stir
2. sense_key=cause%2:32:00:: | definition=cause to do; cause to act in a specified manner | synonyms=induce, stimulate, have, get, make | examples=The ads induced me to buy a VCR; My children finally got me to buy a computer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We need choose best indexed sense for "caused" in context: pleural mesothelioma (cancer ... that is usually caused by exposure to asbestos). Meaning exposure to asbestos gives rise to/caused the cancer. Compare senses:
1. cause%2:36:00:: give rise to; cause to happen or occur, not always intentionally; do/make. This fits cause an event/disease to occur (asbestos caused mesothelioma).
2. cause%2:32:00:: cause to do; cause to act; e.g., induce someone to do something; takes animate-ish/doing? not event. "cancer is caused by exposure" is not causing someone/something to do/act in a specified manner? It's giving rise to a disease/state. Sense 1 best.

Return JSON object exactly like {"sense_index": 3}. Our index options 1 and 2. So {"sense_index": 1}. Need only JSON object.

provider: Together


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: used
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is <t>used</t> together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=use%2:34:01:: | definition=put into service; make work or employ for a particular purpose or for its inherent or natural purpose | synonyms=utilize, utilise, apply, employ | examples=use your head!; we only use Spanish at home
2. sense_key=use%2:34:02:: | definition=take or consume (regularly or habitually) | synonyms=habituate | examples=She uses drugs rarely
3. sense_key=use%2:34:00:: | definition=use up, consume fully | synonyms=expend | examples=The legislature expended its time on school questions
4. sense_key=use%2:41:14:: | definition=seek or achieve an end by using to one's advantage | examples=She uses her influential friends to get jobs; The president's wife used her good connections
5. sense_key=use%2:41:04:: | definition=avail oneself to | synonyms=practice, apply | examples=apply a principle; practice a religion
6. sense_key=use%2:41:03:: | definition=habitually do something (use only in the past tense) | examples=She used to call her mother every week but now she calls only occasionally; I used to get sick when I ate in that dining hall

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We need answer as JSON {"sense_index": n}. Need determine sense for "used" in sentence "Alimta is used together with cisplatin ..." It means put into service; utilize; employed/used for a purpose. Sense 1 definition put into service; employ for particular purpose. In this medical context, Alimta is used/employed together with cisplatin. That's use%2:34:01:: sense index 1 in candidate list. Note sense 3 use up consume fully; not relevant. Sense 4 seek achieve end by using to one's advantage; no. Sense 5 avail oneself to; no. Sense 6 habitual past; no. So index 1.
Need only JSON.

provider: DeepInfra


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer <t>medicine</t>) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target word "medicine" in the given context. Let me analyze the context carefully.

The context is about Alimta, a cancer treatment drug. The specific sentence containing "medicine" is: "Alimta is used together with cisplatin (another anticancer <t>medicine</t>)..."

So here, "medicine" is referring to cisplatin, which is another anticancer drug/treatment. It's talking about a substance used to treat disease.

Let me look at the candidate senses:
1. medicine%1:09:00:: - the branches of medical science that deal with nonsurgical techniques (medical specialty) - This is about a field of study, not a substance.
2. medicine%1:06:00:: - (medicine) something that treats or prevents or alleviates the symptoms of disease (medication, medicament, medicinal drug) - This refers to a drug/substance.
3. medicine%1:04:00:: - the learned profession that is mastered by graduate training in a medical school (practice of medicine) - This is about the profession.
4. medicine%1:04:02:: - punishment for one's actions (music) - This is idiomatic.

In the context, "cisplatin (another anticancer medicine)" clearly refers to cisplatin as a drug/medication used to treat cancer. So sense 2 is the best fit.

The user wants only a JSON object: {"sense_index": 2}

provider: Moonshot AI


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the <t>cancer</t> is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer with JSON only. Need choose best sense. Context is medical, cancer as disease. Sense 1 is malignant growth/tumor. So index 1. Need output {"sense_index": 1}. Ensure no extra text.

provider: Cloudflare


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: remove
Target surface form: removed
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be <t>removed</t> by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=remove%2:30:00:: | definition=remove something concrete, as by lifting, pushing, or taking off, or remove something abstract | synonyms=take, take away, withdraw | examples=remove a threat; remove a wrapper
2. sense_key=remove%2:41:00:: | definition=remove from a position or an office
3. sense_key=remove%2:40:00:: | definition=dispose of | synonyms=get rid of | examples=Get rid of these old shoes!; The company got rid of all the dead wood
4. sense_key=remove%2:41:02:: | definition=cause to leave | synonyms=take out, move out | examples=The teacher took the children out of the classroom
5. sense_key=remove%2:38:00:: | definition=shift the position or location of, as for business, legal, educational, or military purposes | synonyms=transfer | examples=He removed his children to the countryside; Remove the troops to the forest surrounding the city
6. sense_key=remove%2:30:01:: | definition=go away or leave | synonyms=absent | examples=He absented himself
7. sense_key=remove%2:41:01:: | definition=kill intentionally and with premeditation | synonyms=murder, slay, hit, dispatch, bump off, off | examples=The mafia boss ordered his enemies murdered
8. sense_key=remove%2:30:02:: | definition=get rid of something abstract | synonyms=take away | examples=The death of her mother removed the last obstacle to their marriage; God takes away your sins

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer JSON only. Need choose best sense for "removed" in context: cancer cannot be removed by surgery alone. Meaning physically take out/excise tumor. Candidate senses: 1 remove something concrete, as by lifting, pushing, or taking off, or remove something abstract; synonyms take, take away, withdraw; examples remove a threat; remove a wrapper. That fits surgical removal of tumor (concrete object). Sense 3 dispose of/get rid of old shoes/dead wood. Sense 8 get rid of something abstract. The tumor is concrete physical tissue, so sense 1. Need output {"sense_index": 1}. Ensure only JSON.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: surgery
Target surface form: surgery
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by <t>surgery</t> alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=surgery%1:09:00:: | definition=the branch of medical science that treats disease or injury by operative procedures | examples=he is professor of surgery at the Harvard Medical School
2. sense_key=surgery%1:06:01:: | definition=a room where a doctor or dentist can be consulted | examples=he read the warning in the doctor's surgery
3. sense_key=surgery%1:06:00:: | definition=a room in a hospital equipped for the performance of surgical operations | synonyms=operating room, OR, operating theater, operating theatre | examples=great care is taken to keep the operating rooms aseptic
4. sense_key=surgery%1:04:01:: | definition=a medical procedure involving an incision with instruments; performed to repair damage or arrest disease in a living body | synonyms=operation, surgical operation, surgical procedure, surgical process | examples=they will schedule the operation as soon as an operating room is available; he died while undergoing surgery

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: The context describes Alimta being used for cancer that "cannot be removed by surgery alone." Here, "surgery" refers to a medical procedure involving an incision with instruments to remove the cancer. Sense 4 has synonyms like operation, surgical operation, surgical procedure, surgical process, and examples involving medical procedures performed on the body. The context is clearly about a surgical procedure, not a branch of medical science (sense 1), a doctor's consultation room (sense 2), or a hospital room (sense 3). So the best sense is sense 4.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: alone
Target surface form: alone
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery <t>alone</t>) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=alone%5:00:00:unsocial:00 | definition=isolated from others | examples=could be alone in a crowded room; was alone with her thoughts
2. sense_key=alone%5:00:00:unaccompanied:00 | definition=lacking companions or companionship | synonyms=lone, lonely, solitary | examples=he was alone when we met him; she is alone much of the time
3. sense_key=alone%5:00:00:exclusive:00 | definition=exclusive of anyone or anything else | synonyms=only | examples=she alone believed him; cannot live by bread alone
4. sense_key=alone%5:00:00:incomparable:00 | definition=radically distinctive and without equal | synonyms=unique, unequaled, unequalled, unparalleled | examples=he is alone in the field of microbiology; this theory is altogether alone in its penetration of the problem

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We need answer JSON. Need determine best WordNet sense for alone in phrase "cannot be removed by surgery alone". Definition synonymous with "only" / exclusive.
Sense 3: exclusive of anyone or anything else; synonyms=only; cannot live by bread alone. Fits: surgery alone = surgery only. So index 3. Return JSON only. Need ensure no extra.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: spread
Target surface form: spread
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has <t>spread</t>, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=spread%2:35:00:: | definition=distribute or disperse widely | synonyms=distribute | examples=The invaders spread their language all over the country
2. sense_key=spread%2:35:07:: | definition=become distributed or widespread | synonyms=propagate | examples=the infection spread; Optimism spread among the population
3. sense_key=spread%2:42:00:: | definition=spread across or over | synonyms=overspread | examples=A big oil spot spread across the water
4. sense_key=spread%2:35:03:: | definition=spread out or open from a closed or folded state | synonyms=unfold, spread out, open | examples=open the map; spread your arms
5. sense_key=spread%2:32:00:: | definition=cause to become widely known | synonyms=circulate, circularize, circularise, distribute, disseminate, propagate | examples=spread information; circulate a rumor
6. sense_key=spread%2:32:02:: | definition=become widely known and passed on | synonyms=go around, circulate | examples=the rumor spread; the story went around in the office
7. sense_key=spread%2:38:00:: | definition=strew or distribute over an area | synonyms=scatter, spread out | examples=He spread fertilizer over the lawn; scatter cards across the table
8. sense_key=spread%2:38:02:: | definition=move outward | synonyms=diffuse, spread out, fan out | examples=The soldiers fanned out
9. sense_key=spread%2:35:12:: | definition=cover by spreading something over | examples=spread the bread with cheese
10. sense_key=spread%2:35:13:: | definition=distribute over a surface in a layer | examples=spread cheese on a piece of bread

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We need choose single best indexed sense for target 'spread' in context. The context: medical description of Alimta for cancer. Sentence: "when the cancer is unresectable ... and malignant (has spread, or is likely to spread easily, to other parts of the body)". So 'spread' means cancer extending to other body parts, distribute/disperse widely? Let's examine candidate senses:

1. distribute or disperse widely; example invaders spread language. Transitive.
2. become distributed or widespread; intransitive; examples infection spread, optimism spread. This fits cancer has spread = became distributed/widespread.
3. spread across or over; overspread, big oil spot spread across water. Maybe physical spread across surface.
4. spread out/open from folded state; not.
5. cause to become widely known; not.
6. become widely known and passed on; not.
7. strew/distribute over area; scatter; transitive.
8. move outward; diffuse/fan out; intransitive? "The soldiers fanned out" physical outward movement.
9. cover by spreading something over; transitive.
10. distribute over surface in layer; transitive.

In phrase "cancer has spread ... to other parts of the body" intransitive, disease propagation. Sense 2: become distributed or widespread; synonyms propagate; examples infection spread. Also sense 2 sense_key spread%2:35:07. Is there sense of disease? It's not explicitly listed in candidates? Actually sense 2 (%2:35:07) definition become distributed or widespread, synonyms propagate, examples infection spread. This captures disease spreading intrinsically. Could be sense 8 move outward for cells? But the common WordNet sense for disease spread is %2:35:07. So answer index 2.

Need output JSON exactly {"sense_index": 2}. Only that.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: likely
Target surface form: likely
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is <t>likely</t> to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=likely%3:00:00:: | definition=has a good chance of being the case or of coming about | examples=these services are likely to be available to us all before long; she is likely to forget
2. sense_key=likely%3:00:04:: | definition=likely but not certain to be or become true or real | synonyms=probable | examples=a likely result; he foresaw a probable loss
3. sense_key=likely%5:00:00:prospective:00 | definition=expected to become or be; in prospect | synonyms=potential | examples=potential clients
4. sense_key=likely%5:00:00:credible:00 | definition=within the realm of credibility | examples=not a very likely excuse

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 The user wants me to disambiguate the word "likely" in context. Let me analyze.

Context: "has spread, or is likely to spread easily, to other parts of the body"

Candidate senses:
1. "has a good chance of being the case or of coming about" - examples: "these services are likely to be available to us all before long"; "she is likely to forget"
2. "likely but not certain to be or become true or real" - synonyms=probable
3. "expected to become or be; in prospect" - synonyms=potential
4. "within the realm of credibility"

The context: "is likely to spread easily" - this is about something having a good chance/probability of occurring. It matches sense 1's example "she is likely to forget" which uses "likely to + verb".

Sense 1 is the standard adjective sense with "likely to" construction, meaning "has a good chance of being the case or of coming about." This fits perfectly.

Sense 2 is also about being probable, but the examples "a likely result" use it as an attributive adjective before a noun (a likely N). The context here is predicative with "is likely to spread."

Sense 3 is about prospective/potential - doesn't fit as well.
Sense 4 is about credibility of excuses - doesn't fit.

The best answer is sense 1.

provider: Venice


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: spread
Target surface form: spread
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to <t>spread</t> easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=spread%2:35:00:: | definition=distribute or disperse widely | synonyms=distribute | examples=The invaders spread their language all over the country
2. sense_key=spread%2:35:07:: | definition=become distributed or widespread | synonyms=propagate | examples=the infection spread; Optimism spread among the population
3. sense_key=spread%2:42:00:: | definition=spread across or over | synonyms=overspread | examples=A big oil spot spread across the water
4. sense_key=spread%2:35:03:: | definition=spread out or open from a closed or folded state | synonyms=unfold, spread out, open | examples=open the map; spread your arms
5. sense_key=spread%2:32:00:: | definition=cause to become widely known | synonyms=circulate, circularize, circularise, distribute, disseminate, propagate | examples=spread information; circulate a rumor
6. sense_key=spread%2:32:02:: | definition=become widely known and passed on | synonyms=go around, circulate | examples=the rumor spread; the story went around in the office
7. sense_key=spread%2:38:00:: | definition=strew or distribute over an area | synonyms=scatter, spread out | examples=He spread fertilizer over the lawn; scatter cards across the table
8. sense_key=spread%2:38:02:: | definition=move outward | synonyms=diffuse, spread out, fan out | examples=The soldiers fanned out
9. sense_key=spread%2:35:12:: | definition=cover by spreading something over | examples=spread the bread with cheese
10. sense_key=spread%2:35:13:: | definition=distribute over a surface in a layer | examples=spread cheese on a piece of bread

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer with JSON object sense_index. Context: medical cancer spread. Target word 'spread' - likely malignant (has spread, or is likely to spread easily, to other parts of the body). Means metastasize/propagate to other body parts. Candidate senses: 1 distribute widely (transitive), 2 become distributed or widespread (intransitive), 3 spread across/over, 4 open, 5 cause known, 6 become known, 7 strew, 8 move outward (fanned), 9 cover, 10 layer. Here 'cancer has spread' intransitive, distribution/widespread; 'is likely to spread easily' propagation. Sense 2: become distributed or widespread synonyms propagate. The earlier phrase 'has spread' matches infection spread example. So best indexed sense among options is 2. Output JSON.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: easily
Target surface form: easily
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread <t>easily</t>, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=easily%4:02:01:: | definition=with ease (`easy' is sometimes used informally for `easily') | synonyms=easy | examples=she was easily excited; was easily confused
2. sense_key=easily%4:02:06:: | definition=without question | examples=easily the best book she's written
3. sense_key=easily%4:02:05:: | definition=indicating high probability; in all likelihood | synonyms=well | examples=I might well do it; a mistake that could easily have ended in disaster

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 We need perform WSD for target lemma easily surface form easily in given context. Need choose best indexed sense among 1,2,3. Return JSON {"sense_index": n}. No sense key.
We must reason. Context: medical info about Alimta used when cancer unresectable and malignant (has spread, or is likely to spread easily to other parts of the body). Here "easily" modifies "spread", meaning with ease, readily. That is sense 1: with ease. Also can relate to easy in sense of without difficulty. The other senses: without question "easily the best book" indicating degree; high probability "could easily have ended" are not applicable. So answer index 1. Need ensure JSON only.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: other
Target surface form: other
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to <t>other</t> parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=other%3:00:00:: | definition=not the same one or ones already mentioned or implied; - the White Queen | examples=today isn't any other day; the construction of highways and other public works
2. sense_key=other%5:00:00:past:00 | definition=recently past | examples=the other evening
3. sense_key=other%5:00:02:past:00 | definition=belonging to the distant past | synonyms=early, former | examples=the early inhabitants of Europe; former generations
4. sense_key=other%5:00:00:strange:00 | definition=very unusual; different in character or quality from the normal or expected; - Lance Morrow | examples=a strange, other dimension...where his powers seemed to fail

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer JSON object only. Need choose sense index for target word "other" in context: "... malignant (has spread, or is likely to spread easily, to other parts of the body) ..." The meaning: not the same one or ones already mentioned or implied; additional/different parts of body. Candidate 1 fits. Sense 5:00:00:past refers recently past (other evening), not. Candidate 3 distant past. Candidate 4 strange. So answer {"sense_index": 1}. Need only JSON, no explanation.

provider: Novita


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: part
Target surface form: parts
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other <t>parts</t> of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=part%1:24:00:: | definition=something determined in relation to something that includes it | synonyms=portion, component part, component, constituent | examples=he wanted to feel a part of something bigger than himself; I read a portion of the manuscript
2. sense_key=part%1:06:00:: | definition=something less than the whole of a human artifact | synonyms=portion | examples=the rear part of the house; glue the two parts together
3. sense_key=part%1:17:00:: | definition=a portion of a natural object | synonyms=piece | examples=they analyzed the river into three parts; he needed a piece of granite
4. sense_key=part%1:09:02:: | definition=that which concerns a person with regard to a particular role or situation | examples=it requires vigilance on our part; they resisted every effort on his part
5. sense_key=part%1:15:00:: | definition=the extended spatial location of something | synonyms=region | examples=the farming regions of France; religions in all parts of the world
6. sense_key=part%1:04:01:: | definition=the actions and activities assigned to or required or expected of a person or group | synonyms=function, office, role | examples=the function of a teacher; the government must do its part
7. sense_key=part%1:09:01:: | definition=an actor's portrayal of someone in a play | synonyms=character, role, theatrical role, persona | examples=she played the part of Desdemona
8. sense_key=part%1:21:00:: | definition=assets belonging to or due to or contributed by an individual person or group | synonyms=share, portion, percentage | examples=he wanted his share in cash
9. sense_key=part%1:09:00:: | definition=one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division | examples=the written part of the exam; the finance section of the company
10. sense_key=part%1:08:01:: | definition=a line of scalp that can be seen when sections of hair are combed in opposite directions | synonyms=parting | examples=his part was right in the middle
11. sense_key=part%1:10:00:: | definition=the melody carried by a particular voice or instrument in polyphonic music | synonyms=voice | examples=he tried to sing the tenor part
12. sense_key=part%1:04:03:: | definition=the part played by a person in bringing about a result | synonyms=contribution, share | examples=I am proud of my contribution in advancing the project; they all did their share of the work

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We need choose single best indexed sense for target surface form "parts" from context. Context: malignant (has spread, or is likely to spread easily, to other parts of the body). So "parts" means regions/areas/locations of the body. Need identify sense among candidates.

Candidates include sense 5 part%1:15:00:: definition=the extended spatial location of something | synonyms=region | examples=religions in all parts of the world. That fits other parts of the body (spatial locations/regions). Sense 3 part%1:17:00:: definition=a portion of a natural object | synonyms=piece | examples=they analyzed the river into three parts / piece of granite. Body is natural object. But phrase "parts of the body" idiomatic likely refers to body parts/regions. WordNet: part%1:15:00:: "the extended spatial location of something" includes "regions of France", "all parts of the world". This sense probably best for "other parts of the body" (extended spatial location/regions of body). However sense 17-00 "a portion of a natural object" could also apply (body part). Let's compare.

WordNet noun "part" senses: 1:06 human artifact, 1:17 natural object (piece), 1:24 relation (in relation to includes it), 1:15 region/extended spatial location. The example "look at them! They are my body parts vs parts of the body"? Hmm.

Body parts are generally natural objects; WordNet has separate sense "body part"? The target lemma part, not "body part". Context: "other parts of the body" should map to part%1:15:00:: because of "parts of the world"? Actually WordNet 1:15:00 definition: "the extended spatial location of something" (e.g., farming regions of France; religions in all parts of the world). The body context "other parts of the body" = other regions/locations of body. I think answer index 5.

We need only JSON object exactly like {"sense_index": 3}. So output {"sense_index": 5}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: body
Target surface form: body
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the <t>body</t>), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=body%1:08:00:: | definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
2. sense_key=body%1:14:00:: | definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium; the student body
3. sense_key=body%1:08:02:: | definition=a natural object consisting of a dead animal or person | synonyms=dead body | examples=they found the body in the lake
4. sense_key=body%1:17:00:: | definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. sense_key=body%1:08:01:: | definition=the body excluding the head and neck and limbs | synonyms=torso, trunk | examples=they moved their arms and legs and bodies
6. sense_key=body%1:14:02:: | definition=a collection of particulars considered as a system | examples=a body of law; a body of doctrine
7. sense_key=body%1:07:00:: | definition=the property of holding together and retaining its shape | synonyms=consistency, consistence, eubstance | examples=wool has more body than rayon; when the dough has enough consistency it is ready to bake
8. sense_key=body%1:10:00:: | definition=the central message of a communication | examples=the body of the message was short
9. sense_key=body%1:07:01:: | definition=the main mass of a thing
10. sense_key=body%1:06:01:: | definition=a resonating chamber in a musical instrument (as the body of a violin) | synonyms=soundbox
11. sense_key=body%1:06:00:: | definition=the external structure of a vehicle | examples=the body of the car was badly rusted

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We need do WSD for target word body in context. Need choose single best indexed sense among candidates. Target in sentence: "...has spread, or is likely to spread easily, to other parts of the body". This is about human body as entire structure of organism. Candidate 1 body%1:08:00:: entire structure of organism (animal, plant, human). Candidate 5 body%1:08:01:: body excluding head/neck/limbs (torso). Candidate 3 dead body. Candidate 4 individual 3D object. Here "other parts of the body" refers organism. Usually WSD for "parts of the body" uses body as organism? Let's examine. "to other parts of the body" means metastasize to other parts of the human body. Sense 1 definition entire structure of organism (an animal, plant, or human being). That is best. Sense 5 is torso excluding head/neck/limbs; metastasis can go to head limbs etc., and phrase "parts of the body" may be ambiguous but the base noun body here means entire physical organism. So choose sense_index 1.

Need return JSON object exactly like {"sense_index": 3}. So {"sense_index": 1}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in <t>patients</t> who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer with JSON only. Need choose sense index. Context: medical patients receiving drug. Sense 1: person requiring medical care. Sense 2: semantic role. Clearly sense 1. Return {"sense_index": 1}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicines
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (<t>medicines</t> for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer JSON only. Need choose sense for "medicines" in context: "chemotherapy (medicines for cancer)". This refers to substances that treat disease, i.e., medication. Candidate sense 2: medicine%1:06:00:: definition something that treats or prevents or alleviates symptoms of disease; synonyms medication, medicament, medicinal drug. So index 2. Ensure output exactly {"sense_index": 2}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for <t>cancer</t>) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation on the target lemma "cancer" in the given context. I need to choose the single best indexed sense and return a JSON object.

 Context analysis: The text is about Alimta, a medicine used to treat cancer. It specifically mentions "medicines for <t>cancer</t>" in the phrase "chemotherapy (medicines for <t>cancer</t>)". This is clearly referring to the disease/illness sense of cancer.

 Candidate senses:
 1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
 2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
 3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
 4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
 5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

 The context is about medicine treating cancer, which is a malignant growth or tumor. So sense 1 is correct.

 Sense 1 matches perfectly - it's the disease meaning, relevant to medical/treatment context.

 The answer should be JSON: {"sense_index": 1}

 I need to make sure I only return the JSON object exactly as requested.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: advanced
Target surface form: advanced
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before <t>advanced</t> or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=advanced%5:00:00:precocious:00 | definition=farther along in physical or mental development | examples=the child's skeletal age was classified as `advanced'; children in the advanced classes in elementary school read far above grade average
2. sense_key=advanced%5:00:00:late:02 | definition=comparatively late in a course of development | examples=the illness had reached an advanced stage; an advanced state of exhaustion
3. sense_key=advanced%5:00:00:progressive:01 | definition=ahead of the times | synonyms=forward-looking, innovative, modern | examples=the advanced teaching methods; had advanced views on the subject
4. sense_key=advanced%5:00:02:high:02 | definition=at a higher level in training or knowledge or skill | examples=an advanced degree; an advanced text in physics
5. sense_key=advanced%5:00:00:high-tech:00 | definition=ahead in development; complex or intricate | synonyms=sophisticated | examples=advanced technology; a sophisticated electronic control system
6. sense_key=advanced%5:00:00:late:00 | definition=far along in time | synonyms=ripe | examples=a man of advanced age; advanced in years
7. sense_key=advanced%5:00:00:civilized:00 | definition=(of societies) highly developed especially in technology or industry | examples=advanced societies; an advanced country technologically
8. sense_key=advanced%5:00:00:front:00 | definition=situated ahead or going before | synonyms=advance, in advance | examples=an advance party; at that time the most advanced outpost was still east of the Rockies

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer only JSON with sense_index. Need choose among candidate senses for 'advanced' in context: advanced or metastatic non-small cell lung cancer. This means cancer at a later stage, far along in development/progression. Candidate senses: 1 precocious development. 2 comparatively late in a course of development; examples illness had reached an advanced stage. 3 progressive, innovative. 4 higher level in training. 5 ahead in development/high-tech. 6 far along in time (age). 7 societies. 8 situated ahead / going before. In medical context, advanced cancer = late stage, far along in course of progression. Sense 2 best. Need return {"sense_index": 2}.

provider: AkashML


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cell
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small <t>cell</t> lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer with JSON {"sense_index": X}. Need determine best sense for "cell" in phrase "non-small cell lung cancer". In oncology, "non-small cell lung cancer" refers to types of lung cancer that arise from epithelial cells; here "cell" means biological cell. Candidate sense 2 is biology basic structural and functional unit. Therefore index 2. Ensure only JSON.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: affect
Target surface form: affecting
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not <t>affecting</t> the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=affect%2:30:00:: | definition=have an effect upon | synonyms=impact, bear upon, bear on, touch on, touch | examples=Will the new rules affect me?
2. sense_key=affect%2:29:00:: | definition=act physically on; have an effect upon | examples=the medicine affects my heart rate
3. sense_key=affect%2:42:00:: | definition=connect closely and often incriminatingly | synonyms=involve, regard | examples=This new ruling affects your business
4. sense_key=affect%2:32:00:: | definition=make believe with the intent to deceive | synonyms=feign, sham, pretend, dissemble | examples=He feigned that he was ill; He shammed a headache
5. sense_key=affect%2:37:00:: | definition=have an emotional or cognitive impact upon | synonyms=impress, move, strike | examples=This child impressed me as unusually mature; This behavior struck me as odd

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We need answer JSON only. We must disambiguate "affecting" in context: "advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells." It's about cancer (disease) not impacting/involving the squamous cells. The phrase "affecting the squamous cells" means having an effect upon, acting on, or involving the squamous cells? Let's examine candidate senses.

Candidate 1: affect%2:30:00:: have an effect upon; synonyms impact, bear upon, bear on, touch on, touch; examples Will the new rules affect me? This is generic to have an effect upon.

Candidate 2: affect%2:29:00:: act physically on; have an effect upon; examples the medicine affects my heart rate. This is specifically act physically on.

Candidate 3: affect%2:42:00:: connect closely and often incriminatingly; synonyms involve, regard; examples This new ruling affects your business. This is involve/regard, often in a legal sense, incriminating involvement.

Candidate 5: emotional/cognitive impact.

In medical text: "cancer that is not affecting the squamous cells." Here "affect" means "affecting/involving"? In medical contexts, disease affecting an organ/cells means it acts upon, has an effect on, or involves. We need choose best indexed sense.

WordNet senses: sense 1 have an effect upon; sense 2 act physically on; sense 3 involve/regard. The phrase "not affecting the squamous cells" could be paraphrased as "not involving the squamous cells" (sense 3) or "not having an effect upon the squamous cells" (sense 1/2). Which is the best? Need consider glosses and examples. Candidate 3 definition "connect closely and often incriminatingly" with synonyms involve, regard. Example: "This new ruling affects your business." This sense is to involve as a concern, to relate to. It can be used in "the cancer affects the squamous cells"? Possibly not incriminating, but "involve" is a synonym. However WordNet sense 3 maybe "affect" as "concern; have to do with" but the gloss says connect closely and often incriminatingly, synonyms involve, regard. In medical language, "affecting" means "involving" often. But does WordNet consider that sense 3? Let's recall WordNet verb senses for affect:

From WordNet:
affect (v) 1: have an effect upon; (syn: impact, bear upon, bear on, touch on, touch)
2: act physically on; have an effect upon; (as of a drug)
3: connect closely and often incriminatingly; (syn: involve, regard) "This new ruling affects your business"
4: make believe with the intent to deceive; (syn: feign, sham, pretend, dissemble)
5: have an emotional or cognitive impact upon; (syn: impress, move, strike)

Note sense 2 is specific: "act physically on; have an effect upon". Example "the medicine affects my heart rate". The context is a disease acting physically on squamous cells? Cancer physically affects cells. But the wording "lung cancer that is not affecting the squamous cells" describes the cancer not involving squamous cells. The cells are part of the lung tissue; NSCLC not affecting squamous cells means not of squamous cell type/non-squamous. "Affect" in the sense of "influence" or "have an effect upon" maybe more generic.

Need choose single best. Let's reason with WordNet examples/glosses. Target surface form is present participle "affecting". The sentence: "advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells." This means the cancer does not involve (is not located in) the squamous cells. Candidate 3 synonyms include involve, which fits. But definition includes "often incriminatingly", which doesn't fit. However instructions say WordNet glosses are schematic; use context, examples, synonyms. The synonyms "involve, regard" strongly match "cancer affecting cells". Candidate 1 synonyms impact, touch on also match. Candidate 2 physically acting.

Potential nuance: In WordNet, sense 3 is "affect" as "connect closely and often incriminatingly", similar to "involve" in sense of implicate. Example "This new ruling affects your business" - the ruling concerns/involves your business. Could "cancer affecting cells" be this sense? Maybe, if the cells are involved. But the "incriminatingly" part is weird. However broad sense "involve" is key.

Let's search mental corpus: In WordNet, "affect" sense 3 likely from the verb 'to affect' meaning 'to make a show of; pretend' no that's sense 4. Sense 3 = "to involve, implicate". Yes historically "affect" can mean "to aim at, aspire or pretend" but WordNet's sense 3 is "connect closely and often incriminatingly; 'This new ruling affects your business'". That's like "concern". So "cancer affecting the squamous cells" means cancer concerns/involves squamous cells. That aligns with sense 3.

But is there a medical sense in WordNet? Sense 2 is "act physically on; have an effect upon" example "the medicine affects my heart rate". This is about physical effect of a substance on a body part. Here cancer is a disease/pathology, not medicine. It "affects squamous cells" physically? It might. The phrase "medicine affects my heart rate" is similar to "cancer affects cells". However, sense 2 specifically says "act physically on; have an effect upon" and is likely a hyponym of sense 1 for physical/biological action. Since the target is a disease affecting cells (biological), sense 2 might be the best.

Let's examine sense 1 examples: "Will the new rules affect me?" It is general impact. Sense 2 example: "the medicine affects my heart rate". This is biological/physical effect. Context is drug information about cancer. The relative clause "cancer that is not affecting the squamous cells" — the cancer is not acting on the squamous cells. That is a physical/biological effect. Thus sense 2 might be most precise.

But the phrase "not affecting the squamous cells" in oncology means histologically not squamous cell carcinoma, i.e., non-squamous NSCLC. The cancer cells themselves are not squamous cells? Wait "lung cancer that is not affecting the squamous cells" means the cancer is not in the squamous cells? Non-small cell lung cancer includes adenocarcinoma (non-squamous) and squamous cell carcinoma. "Not affecting squamous cells" = non-squamous. Here "affecting" means "involving" (pathology involves cell type). Sense 3 synonym involve may be best.

Need decide. Let's consider candidate sense indexing: The user wants "single best indexed sense". We must not hedge. We need output JSON with sense_index: integer matching candidate numbering 1-5. We should pick the number. Need be accurate.

Let's deeply analyze WordNet sense distinctions.

Sense 1: affect%2:30:00:: verb.contact? Actually WordNet lexicographer file? 2:30 is verb.change? Let me recall Princeton WordNet pointer: affect%2:30:00:: (verb.contact? Actually WordNet sense keys format lemma%ss:tt:ww:: where ss is syntactic category (2 verb), tt is lexicographer file number. 30 is "verb.change"? Let's recall lexicographer file numbers: 00 adj.all, 01 adj.pert, etc. For verbs: 00 verb.body, 01 verb.change, 02 verb.cognition, 03 verb.communication, 04 verb.competition, 05 verb.consumption, 06 verb.contact, 07 verb.creation, 08 verb.emotion, 09 verb.motion, 10 verb.perception, 11 verb.possession, 12 verb.social, 13 verb.stative, 14 verb.weather, 15 verb? Actually maybe different. But 2:30? That seems high; perhaps WordNet 3.1 uses lexfile numbers: 00 = verb.body, 01 = verb.change, 02 = verb.cognition, 03 = verb.communication, 04 = verb.competition, 05 = verb.consumption, 06 = verb.contact, 07 = verb.creation, 08 = verb.emotion, 09 = verb.motion, 10 = verb.perception, 11 = verb.possession, 12 = verb.social, 13 = verb.stative, 14 = verb.weather, 15 = verb? Wait 30 is not standard for WordNet 3.0? Actually sense keys use lexicographer file number maybe decimal: 30? Hmm. Let me recall WordNet 3.1 sense key examples: "affect%2:30:00::" maybe lexfile 30 = verb.change? Not sure. Maybe numbering: 29 verb.body? 30 verb.change? 31 verb.cognition? Let's not rely.

The definitions themselves matter.

Sense 2: "act physically on; have an effect upon". This sense is in verb.body maybe (2:29). Sense 1 is verb.change (2:30). Sense 3 is verb.stative? Actually "connect closely" might be verb.contact? Hmm.

Could use examples: Sense 1 example rules affect me (change/influence). Sense 2 example medicine affects heart rate (physical). In our context, a disease affecting cells is a physical/biological effect, so sense 2.

However "not affecting the squamous cells" is not talking about the disease causing a change in squamous cells? The cancer is "advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells." It could mean the cancer is not of squamous cell type; not that it doesn't act on them. But "affecting" with "cells" as object in medicine usually means "involving" or "affecting". If cancer affects squamous cells, it involves them. Sense 3's synonym involve directly supports that.

Let's see if the phrase "affecting your business" in sense 3 is similar: a ruling affects your business = involves/concerns your business. "Cancer affects squamous cells" = involves them. That is a very close parallel. The incriminating nuance is irrelevant; glosses are schematic.

But does WordNet sense 3 specifically mean "implicate" as in "involve (someone) in a crime"? Example "This new ruling affects your business" not incriminating. It can mean "have an effect on" in a legal/business sense. The synonym "regard" means concern. So it's general "concern". The cancer concerns squamous cells? Not quite.

Let's parse syntax: "lung cancer that is not affecting the squamous cells." Here "affecting" is a transitive verb taking "the squamous cells" as object. In plain English, "affect" = "have an effect on". That's sense 1. Sense 2 is a more specific kind of sense 1 where the effect is physical. The cancer's effect on squamous cells is physical, so sense 2. But if the intended meaning is "not involving squamous cells", sense 1 covers "have an effect upon". Yet sense 3 "involve" maybe best.

We can think of WordNet mapping in WSD datasets. For "affect" in biomedical contexts, which sense is annotated? SemCor? Let's recall examples: "affecting" as present participle. In WordNet, "affecting" is the participle/adjective maybe. But target lemma affect.

Example from SemCor: "The *affect* is a noun in psychology." Not relevant.

Let's manually look up WordNet gloss for affect (verb) maybe via memory:
- S: (v) affect, impact, bear upon, bear on, touch on, touch (have an effect upon) "Will the new rules affect me?"
- S: (v) affect (act physically on; have an effect upon) "the medicine affects my heart rate"
- S: (v) involve, affect, regard (connect closely and often incriminatingly) "This new ruling affects your business"
- S: (v) feign, sham, pretend, affect, dissemble (make believe with the intent to deceive) "He feigned that he was ill"; "He shammed a headache"
- S: (v) affect, impress, move, strike (have an emotional or cognitive impact upon) ...

Sense 2 is a subordinate of sense 1? It has no synonyms listed, just "act physically on; have an effect upon". It is specific to physical action, often of drugs. The object "squamous cells" is a biological structure; a cancer physically acts on them. So sense 2 fits more precisely than generic sense 1.

But the sentence is describing the type of cancer based on whether it affects squamous cells. In oncology, one might say "non-squamous NSCLC" not "not affecting the squamous cells." The EMA label perhaps says "non-small cell lung cancer other than predominantly squamous cell histology" or "non-squamous non-small cell lung cancer". But this text says "that is not affecting the squamous cells." It seems plain-language paraphrase: the cancer is not affecting (i.e., not located in, not made of) squamous cells. Sense 2 could imply the cancer is acting on them, which is true if it's located there. But "not affecting" means not acting on them, i.e., non-squamous.

Let's examine synonyms for sense 2: none except "affect". The definition is "act physically on; have an effect upon". This is essentially same as sense 1 but physically. The phrase "medicine affects my heart rate" is about a chemical substance causing a physical change in an organ's function. Cancer affecting cells is also a physical process. So sense 2.

But would a native speaker choose "affecting" sense 1 or 2? Let's try to apply WSD guidelines: choose the sense whose definition and synonyms best match context. Sense 1: "have an effect upon" + synonyms impact, touch. Cancer can impact cells. Sense 2: "act physically on" + example medicine affects heart rate. This directly matches biological effect. Sense 3: "connect closely and often incriminatingly" + synonyms involve, regard. The context is not about incrimination or legal concern, and "regard" is less natural.

Thus sense 2 likely.

However, possible issue: "advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells." The phrase "affecting the squamous cells" might be a non-native translation of "nicht Plattenepithelkarzinom" meaning "not squamous cell". In such contexts, "affect" is used to mean "involve" in a locational/histological sense, not necessarily physical action. But WordNet's sense 3 "involve" covers that. Yet "connect closely and often incriminatingly" seems not fitting. But synonym "involve" does.

Let's inspect sense 3's example "This new ruling affects your business." There, "affects" is synonymous with "concerns" or "applies to". In the EMA text, "cancer that is not affecting the squamous cells" = "cancer that does not concern the squamous cells"? That is awkward.

The user prompt says: "WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense." So we should not overthink incriminating nuance; but we should use examples. Example for sense 2 is a biological effect (medicine -> heart rate). The context is also biological (cancer -> squamous cells). That's a strong clue. Example for sense 3 is a ruling affecting a business, not biological. Example for sense 1 is rules affecting a person, generic. So sense 2's example is most analogous.

I think answer should be {"sense_index": 2}. But let's ensure no hidden trap: surface form "affecting" could be an adjective meaning "moving, touching, emotional" (e.g., "an affecting story")? Candidate 5 is emotional/cognitive impact. The word "affecting" as adjective would be separate, but target lemma is affect and context is progressive/relative clause "that is not affecting the squamous cells." So verb.

Also candidate 4 pretend is irrelevant.

Therefore best indexed sense is 2.

Need return only JSON. Ensure exact format: {"sense_index": 2}. No extra text.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: used
Context:
Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is <t>used</t> in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription.

Candidate senses:
1. sense_key=use%2:34:01:: | definition=put into service; make work or employ for a particular purpose or for its inherent or natural purpose | synonyms=utilize, utilise, apply, employ | examples=use your head!; we only use Spanish at home
2. sense_key=use%2:34:02:: | definition=take or consume (regularly or habitually) | synonyms=habituate | examples=She uses drugs rarely
3. sense_key=use%2:34:00:: | definition=use up, consume fully | synonyms=expend | examples=The legislature expended its time on school questions
4. sense_key=use%2:41:14:: | definition=seek or achieve an end by using to one's advantage | examples=She uses her influential friends to get jobs; The president's wife used her good connections
5. sense_key=use%2:41:04:: | definition=avail oneself to | synonyms=practice, apply | examples=apply a principle; practice a religion
6. sense_key=use%2:41:03:: | definition=habitually do something (use only in the past tense) | examples=She used to call her mother every week but now she calls only occasionally; I used to get sick when I ate in that dining hall

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We need answer with single best indexed sense for the target word "used". Let's analyze.

Target: "used" in sentence: "Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past." This is a medical/drug label context: "Alimta is used in combination with cisplatin..." Means the medicine is employed/utilized for treatment.

Candidate senses:
1. put into service; make work or employ for a particular purpose or for its inherent or natural purpose. Synonyms: utilize, utilise, apply, employ. Examples: use your head!, we only use Spanish at home. This fits: the medicine is employed/utilized for a purpose. Passive "is used".
2. take or consume. Not fit (could be used for drugs? e.g., "She uses drugs rarely", but here "used in combination" not consumption).
3. use up, consume fully. Not fit.
4. seek or achieve an end by using to one's advantage. Slightly similar but implies exploiting something, not medical treatment.
5. avail oneself to. Not fit (apply a principle etc).
6. used to. Past habitual. No because "used in combination" and not "used to".

Hence best sense index is 1. Return JSON {"sense_index": 1}. Need only JSON.

provider: AtlasCloud


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in <t>patients</t> who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need answer as JSON with sense_index. Need disambiguate patients in context. Context about Alimta used in patients (people who require medical care). Sense 1: person requiring medical care. Sense 2: semantic role in grammar. Clearly medical patients. Index 1. Return {"sense_index": 1}.