[User]
Which numbered sense of "kill" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells), which belongs to the group antimetabolites.

Senses:
1. definition=cause to die; put to death, usually intentionally or knowingly | examples=This man killed several people when he tried to rob a bank
2. definition=thwart the passage of | examples=kill a motion
3. definition=end or extinguish by forceful means | examples=Stamp out poverty!
4. definition=be fatal | examples=cigarettes kill
5. definition=be the source of great pain for | examples=These new shoes are killing me!
6. definition=overwhelm with hilarity, pleasure, or admiration | examples=The comedian was so funny, he was killing me!
7. definition=hit with so much force as to make a return impossible, in racket games | examples=She killed the ball
8. definition=hit with great force | examples=He killed the ball
9. definition=deprive of life | examples=AIDS has killed thousands in Africa
10. definition=cause the death of, without intention | examples=She was killed in the collision of three cars
11. definition=drink down entirely | examples=He downed three martinis before dinner
12. definition=mark for deletion, rub off, or erase | examples=kill these lines in the President's speech
13. definition=tire out completely | examples=The daily stress of her work is killing her
14. definition=cause to cease operating | examples=kill the engine
15. definition=destroy a vitally essential quality of or in | examples=Eating artichokes kills the taste of all other foods

reasoning_content:
The user wants me to identify which numbered sense of "kill" is used in the given sentence. Let me analyze the sentence and the definitions.

Sentence: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells), which belongs to the group antimetabolites."

The context is about a medicine (pemetrexed) that kills cells - specifically cells that are dividing, like cancer cells. This is a biological/medical context where the medicine causes cells to die.

Let me look at the senses:

1. cause to die; put to death, usually intentionally or knowingly - This is about killing people intentionally.
2. thwart the passage of - This is about blocking something like a motion.
3. end or extinguish by forceful means - This is more about stamping out abstract things like poverty.
4. be fatal - This is intransitive, meaning something causes death (e.g., cigarettes kill).
5. be the source of great pain for - This is metaphorical, about causing discomfort.
6. overwhelm with hilarity, pleasure, or admiration - This is about being very funny.
7. hit with so much force as to make a return impossible, in racket games - Sports context.
8. hit with great force - Sports/general hitting.
9. deprive of life - This is a general definition about causing death/life to end.
10. cause the death of, without intention - Accidental killing.
11. drink down entirely - Drinking.
12. mark for deletion, rub off, or erase - Editing/deleting.
13. tire out completely - Exhaustion.
14. cause to cease operating - Turning off machines.
15. destroy a vitally essential quality of or in - Destroying qualities.

Now, looking at the sentence: "kills cells that are dividing"

This is about causing cells to die. The medicine causes cell death.

Sense 9: "deprive of life" - examples: "AIDS has killed thousands in Africa"
This seems to fit. AIDS kills people (deprives them of life). The medicine kills cells (deprives them of life).

Sense 1: "cause to die; put to death, usually intentionally or knowingly" - This is typically used for intentional killing of people/animals, often with agency. While the medicine is intentionally used, the definition says "put to death, usually intentionally or knowingly" which suggests intentional agency. But the example is "This man killed several people" - this is about intentional killing of humans.

Sense 9: "deprive of life" - This is more general and applies to causing death in general, including biological contexts like cells, diseases, etc. The example "AIDS has killed thousands in Africa" shows it can be used for disease causing death.

Sense 4: "be fatal" - This is intransitive. The sentence uses "kills" transitively with an object "cells". So sense 4 doesn't fit because it's intransitive (cigarettes kill - cigarettes are the subject doing the killing without object, or rather it's intransitive usage).

Wait, let me check: "cigarettes kill" - this can be transitive or intransitive? Actually, "cigarettes kill" is intransitive in the sense that it doesn't take a direct object there. But "cigarettes kill people" would be transitive. However, the definition says "be fatal" which suggests the subject is the thing that is fatal.

In the sentence: "a medicine that kills cells" - this is transitive. The medicine (subject) kills (verb) cells (object).

Sense 9: "deprive of life" - transitive. "AIDS has killed thousands" - transitive.
Sense 1: "cause to die" - transitive. "This man killed several people" - transitive.

But sense 1 emphasizes "intentionally or knowingly" and "put to death" which is more appropriate for deliberate human/animal killing.

Sense 9 is "deprive of life" which is the biological sense of causing death - appropriate for cells, organisms, etc.

Sense 10: "cause the death of, without intention" - this is accidental. The medicine intentionally kills cells (that's its purpose), so this doesn't fit.

Sense 14: "cause to cease operating" - this is for machines/engines. Cells are not machines in this sense, though metaphorically they could be, but in biological context, killing cells means causing them to die, not just turning them off.

Sense 15: "destroy a vitally essential quality of or in" - this is about destroying qualities, not life.

So the best fit is sense 9: "deprive of life"

But let me double-check sense 1 vs sense 9.

Sense 1: "cause to die; put to death, usually intentionally or knowingly"
- This is the typical intentional killing sense (murder, execution, etc.)
- Example: killing people in a bank robbery

Sense 9: "deprive of life"
- More general biological sense
- Example: AIDS killing thousands, or could be used for predators killing prey, etc.

In medical contexts, when we say a drug "kills" cells, we mean it causes cell death - it deprives the cells of life. This is sense 9.

Actually, looking at WordNet or similar lexical databases (which this seems to be based on), sense 9 is often the specific sense for causing death in general biological contexts.

Sense 1 is specifically for intentional killing (homicide, execution).
Sense 9 is for causing death generally.
Sense 10 is for accidental causing of death.

The sentence is about a cytotoxic medicine that kills dividing cells. This is a biological mechanism - the medicine causes cell death. It deprives the cells of life.

Therefore, the answer should be 9.

Wait, I should also consider sense 4: "be fatal". But "be fatal" is intransitive or requires "to"? Actually, looking at the example "cigarettes kill" - this is intransitive usage. But "cigarettes kill people" would be transitive. However, the definition "be fatal" suggests an intransitive meaning.

In our sentence: "kills cells" - clearly transitive with direct object.

Sense 9: "deprive of life" - the definition fits perfectly for cells.

Let me verify by looking at the pattern of WordNet senses. This looks like WordNet 3.0 or similar.

In WordNet, the senses of kill are roughly:
1. kill, slay (cause to die)
2. kill (thwart)
3. stamp out, kill (end)
4. kill (be fatal)
5. kill (cause pain)
6. kill (overwhelm with humor)
7. kill (sports - hit so can't return)
8. kill (hit with great force)
9. kill (deprive of life) - this is actually a separate sense?
10. kill (cause death without intention)

Actually, looking more carefully, in WordNet:
- kill#1: cause to die; put to death, usually intentionally or knowingly
- kill#2: thwart the passage of
- kill#3: end or extinguish by forceful means
- kill#4: be fatal
- kill#5: be the source of great pain for
- kill#6: overwhelm with hilarity, pleasure, or admiration
- kill#7: hit with so much force as to make a return impossible, in racket games
- kill#8: hit with great force
- kill#9: deprive of life
- kill#10: cause the death of, without intention
- kill#11: drink down entirely
- kill#12: mark for deletion, rub off, or erase
- kill#13: tire out completely
- kill#14: cause to cease operating
- kill#15: destroy a vitally essential quality of or in

Wait, kill#1 and kill#9 seem very similar. Let me think about the distinction.

kill#1: "cause to die; put to death, usually intentionally or knowingly" - This is the agentive, intentional sense used for deliberate actions by animate agents.

kill#9: "deprive of life" - This is a more general sense. The example given is "AIDS has killed thousands in Africa." AIDS is a disease, not an intentional agent. It causes death/deprives of life.

In the sentence: "a medicine that kills cells" - the medicine is the agent. But medicines are not intentional agents. However, they are used intentionally by doctors. But the mechanism is biological - it deprives cells of life.

The key is that "deprive of life" (sense 9) is the appropriate sense for biological contexts where something causes the death of cells, organisms, etc., especially when the agent is not a person acting directly.

Actually, looking at the example for sense 9: "AIDS has killed thousands in Africa" - this is about a disease causing death.

Similarly, "a medicine that kills cells" - the medicine causes the cells to die, deprives them of life.

Sense 1 would be more appropriate for "The doctor killed the patient" (intentionally) or "The murderer killed the victim."

But for cells, sense 9 is more appropriate.

However, I need to be careful. In some dictionaries, "kill" when used for cells might fall under sense 1 (cause to die) or sense 9 (deprive of life).

But given that sense 9 exists with the example about AIDS killing people, and sense 1 has the example about a man killing people in a bank robbery, the distinction seems to be:
- Sense 1: intentional killing by an agent (usually a person)
- Sense 9: causing death generally (diseases, poisons, etc. that deprive of life)

Since pemetrexed is a cytotoxic agent (a chemical substance), and it kills cells, this is analogous to a disease killing people or a poison killing someone. It "deprives of life."

Therefore, the answer is 9.

But let me also check if sense 4 could apply. "be fatal" - "cigarettes kill." This is intransitive. The subject is the thing that is fatal. But in "medicine that kills cells," "cells" is the object. So it's transitive. Sense 4 is intransitive.

Sense 10: "cause the death of, without intention" - example: "She was killed in the collision." This is accidental. Killing cancer cells with medicine is intentional (the medicine is designed to do this), so this doesn't fit.

Sense 14: "cause to cease operating" - kill the engine. This is metaphorical for machines. Cells are not machines.

Sense 15: This is about destroying qualities, not life.

So 9 is definitely the best answer.

One more check: Could it be sense 1? "cause to die; put to death, usually intentionally or knowingly"

The medicine is intentionally administered. But does it "put to death" the cells? "Put to death" is a specific phrase usually used for execution or euthanasia. We don't usually say we "put to death" cancer cells, we say we "kill" them or they are "killed."

Also, the definition says "usually intentionally or knowingly" referring to the agent. The medicine doesn't have intention. The doctor has intention, but the medicine itself is just a chemical that causes death.

In WordNet, sense 9 "deprive of life" is the hypernym or more general sense that covers biological death caused by various means.

Actually, looking at WordNet structure online (mentally), kill#1 is the specific sense for deliberate killing, and kill#9 is for depriving of life in general.

The example "AIDS has killed thousands" maps to sense 9.
The example "This man killed several people" maps to sense 1.

Cytotoxic medicine killing cells is more like AIDS killing people (biological mechanism) than a man killing people (intentional violent act).

Therefore: 9

provider: DeepInfra


attempt_kind: initial

status: success

[User]
Which numbered sense of "cell" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells), which belongs to the group antimetabolites.

Senses:
1. definition=any small compartment | examples=the cells of a honeycomb
2. definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. definition=a device that delivers an electric current as the result of a chemical reaction
4. definition=a small unit serving as part of or as the nucleus of a larger political movement
5. definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver
6. definition=small room in which a monk or nun lives
7. definition=a room where a prisoner is kept

finish_reason: stop

role: assistant

reasoning_content:
 The user wants me to identify which numbered sense of "cell" is used in the given sentence.

The sentence is: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells), which belongs to the group antimetabolites."

The word "cell" appears in the context of "cancer cells" and "cells that are dividing". This is clearly a biological context.

Let me look at the senses:

1. "any small compartment" - examples: cells of a honeycomb. This is a structural/geometric sense.
2. "(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals" - This is the biological sense of cell.
3. "a device that delivers an electric current as the result of a chemical reaction" - This is an electrochemical cell or battery.
4. "a small unit serving as part of or as the nucleus of a larger political movement" - This is a political/social cell (e.g., terrorist cell).
5. "a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver" - This is a cell phone.
6. "small room in which a monk or nun lives" - This is a monastic cell.
7. "a room where a prisoner is kept" - This is a prison cell.

The sentence talks about "cancer cells" and mentions "cytotoxic medicine" that kills "cells that are dividing". This is clearly referring to biological cells (sense 2).

The context mentions:
- "cancer cells" - cancer affects biological cells
- "dividing" - cell division is a biological process
- "cytotoxic medicine" - cytotoxic means toxic to cells (biological cells)

Therefore, the correct sense is 2.

format: unknown

native_finish_reason: stop

provider: DigitalOcean

currency: USD


[User]
Which numbered sense of "divide" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells), which belongs to the group antimetabolites.

Senses:
1. definition=separate into parts or portions | examples=divide the cake into three equal parts
2. definition=perform a division | examples=Can you divide 49 by seven?
3. definition=act as a barrier between; stand between | examples=The mountain range divides the two countries
4. definition=come apart | examples=The two pieces that we had glued separated
5. definition=make a division or separation
6. definition=force, take, or pull apart | examples=He separated the fighting children

reasoning_content:
The user wants me to identify which numbered sense of "divide" is used in the given sentence.

Sentence: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells), which belongs to the group antimetabolites."

The word "dividing" here refers to cells that are undergoing cell division - meaning they are splitting into parts or reproducing by separating into parts.

Let me look at the senses:
1. definition=separate into parts or portions | examples=divide the cake into three equal parts
2. definition=perform a division | examples=Can you divide 49 by seven?
3. definition=act as a barrier between; stand between | examples=The mountain range divides the two countries
4. definition=come apart | examples=The two pieces that we had glued separated
5. definition=make a division or separation
6. definition=force, take, or pull apart | examples=He separated the fighting children

In the context of cells dividing, this refers to the biological process of cell division where a cell separates into two daughter cells. This is most closely related to sense 1: "separate into parts or portions" or possibly sense 4: "come apart".

Wait, let me think more carefully. When cells are "dividing" in a biological context, they are undergoing mitosis or cell division - they are splitting into parts.

Sense 1: "separate into parts or portions" - This seems to fit. Cells separate into parts (two daughter cells).
Sense 4: "come apart" - This is more about things coming apart, like glued pieces separating.

Actually, looking at standard dictionary definitions for biological cell division:
- Cells divide means they split into parts.
- This is sense 1: separate into parts or portions.

Sense 4 is "come apart" which is more about separation of things that were together, like "The two pieces that we had glued separated" - this is an intransitive use meaning to become separated.

But "cells that are dividing" - cells are actively dividing (transitive or intransitive?).

Let me check: "cells that are dividing" - this is intransitive. The cells are doing the action of dividing.

Sense 1 examples: "divide the cake into three equal parts" - this is transitive.
But sense 1 could also work intransitively: "The cells divide."

Sense 4: "come apart" - examples: "The two pieces that we had glued separated" - this uses "separated" not "divided". But this sense is about things coming apart.

Actually, looking at standard WordNet or similar sense inventories:
Sense 1 usually covers the general meaning of separating into parts.
Sense 4 is specifically about coming apart.

For cell biology, when we say cells are dividing, we mean they are undergoing the process of division - separating into parts.

Let me look at the definitions again:
1. separate into parts or portions
4. come apart

"Cells that are dividing" - this is about the biological process of cell division, where one cell becomes two. This is the cells separating into parts.

Between sense 1 and sense 4:
- Sense 1 is typically the transitive sense (divide something) or the general sense of splitting.
- Sense 4 is specifically "come apart" - which could work for cells dividing.

But wait, looking at the example for sense 4: "The two pieces that we had glued separated" - the example uses "separated" not "divided". The definition says "come apart".

Actually, I need to be careful. In many lexical databases:
- Sense 1: divide = separate into parts (can be transitive or intransitive)
- Sense 4: divide = come apart (intransitive)

But looking at the specific wording:
Sense 1: "separate into parts or portions" - this fits cell division perfectly. Cells separate into portions (daughter cells).
Sense 4: "come apart" - this is more general and less specific to the organized process of cell division.

However, looking at the pattern of the senses, sense 1 is the primary sense - to separate into parts.

Let me consider if there's a specific biological sense. No, these are general senses.

Actually, looking at WordNet (which this format resembles):
- divide#1: separate into parts or portions
- divide#2: perform a division
- divide#3: act as a barrier between; stand between
- divide#4: come apart
- divide#5: make a division or separation
- divide#6: force, take, or pull apart

In WordNet:
divide.v.01: separate into parts or portions
divide.v.02: perform a division
divide.v.03: act as a barrier between; stand between
divide.v.04: come apart
divide.v.05: make a division or separation
divide.v.06: force, take, or pull apart

Now, for cells dividing:
- Cells separate into parts (daughter cells) → divide.v.01
- Or cells come apart → divide.v.04

But "come apart" (divide.v.04) has the example: "The two pieces that we had glued separated" - wait, that example actually uses the word "separated" not "divided". That's interesting.

Actually, looking at WordNet more carefully:
WordNet 3.1:
Sense 1: separate into parts or portions -- "divide the cake into three equal parts"
Sense 2: perform a division -- "Can you divide 49 by seven?"
Sense 3: act as a barrier between; stand between -- "The mountain range divides the two countries"
Sense 4: come apart -- "The two pieces that we had glued separated"
Sense 5: make a division or separation
Sense 6: force, take, or pull apart -- "He separated the fighting children"

Wait, looking at sense 4: The example uses "separated" but the word being defined is "divide". This is odd unless these are synsets.

Actually, these look like they might be from a specific dataset. The format suggests WordNet or similar.

For biological cells "dividing", the most appropriate sense is sense 1: "separate into parts or portions".

When cells divide, they separate into parts (two daughter cells). This is the prototypical meaning of divide.

Sense 4 "come apart" suggests a separation that is perhaps less organized or about things that were joined coming apart, like the glued pieces example.

Therefore, the answer should be 1.

Let me double-check:
- "Cells that are dividing" - undergoing cell division
- Cell division is the process by which a parent cell divides into two or more daughter cells
- This is separating into parts or portions
- Sense 1

Yes, sense 1 is correct.

provider: StreamLake


[User]
Which numbered sense of "body" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=the entire structure of an organism (an animal, plant, or human being) | examples=he felt as if his whole body were on fire
2. definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium
3. definition=a natural object consisting of a dead animal or person | examples=they found the body in the lake
4. definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. definition=the body excluding the head and neck and limbs | examples=they moved their arms and legs and bodies
6. definition=a collection of particulars considered as a system | examples=a body of law
7. definition=the property of holding together and retaining its shape | examples=wool has more body than rayon
8. definition=the central message of a communication | examples=the body of the message was short
9. definition=the main mass of a thing
10. definition=a resonating chamber in a musical instrument (as the body of a violin)
11. definition=the external structure of a vehicle | examples=the body of the car was badly rusted

reasoning_content:
 The user wants me to identify which numbered sense of "body" is used in the given sentence. Let me analyze the sentence:

"In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

The context is about pemetrexed (a drug) being converted into an active form inside the body. This is referring to the human/animal body where biological processes occur.

Let me look at the senses:

1. definition=the entire structure of an organism (an animal, plant, or human being) | examples=he felt as if his whole body were on fire
- This fits. The sentence is talking about what happens inside the human/animal body (organism).

2. definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium
- This refers to a group of people, like "a body of students." Doesn't fit.

3. definition=a natural object consisting of a dead animal or person | examples=they found the body in the lake
- This refers to a corpse. Doesn't fit the context of metabolic processes.

4. definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
- This is a physical object in space or general physics. Doesn't fit.

5. definition=the body excluding the head and neck and limbs | examples=they moved their arms and legs and bodies
- This refers to the torso/trunk. While related, the sentence is talking about the entire organism where metabolic processes occur, not just the torso.

6. definition=a collection of particulars considered as a system | examples=a body of law
- This refers to a collection or system of things, like "body of evidence." Doesn't fit.

7. definition=the property of holding together and retaining its shape | examples=wool has more body than rayon
- This is a quality of texture/consistency. Doesn't fit.

8. definition=the central message of a communication | examples=the body of the message was short
- This refers to the main content of a text/email. Doesn't fit.

9. definition=the main mass of a thing
- This is vague, but usually refers to the bulk of something. Could potentially fit, but sense 1 is more specific and accurate for biological contexts.

10. definition=a resonating chamber in a musical instrument (as the body of a violin)
- Specific to musical instruments. Doesn't fit.

11. definition=the external structure of a vehicle | examples=the body of the car was badly rusted
- Refers to cars/vehicles. Doesn't fit.

The sentence is clearly referring to the biological organism (human or animal) where the drug is metabolized. This is sense 1: "the entire structure of an organism (an animal, plant, or human being)."

Wait, let me double-check sense 5. Could it be referring to the torso? The sentence says "In the body" - this is a common way to refer to the entire organism in medical/pharmacological contexts. When we say "in the body" in the context of drug metabolism, we mean inside the organism, not just the torso. So sense 1 is correct.

Sense 1 is the most appropriate answer.

provider: Phala


[User]
Which numbered sense of "convert" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=change from one system to another or to a new plan or policy | examples=We converted from 220 to 110 Volt
2. definition=change the nature, purpose, or function of something | examples=convert lead into gold
3. definition=change religious beliefs, or adopt a religious belief | examples=She converted to Buddhism
4. definition=exchange or replace with another, usually of the same kind or category | examples=Could you convert my dollars into pounds?
5. definition=cause to adopt a new or different faith | examples=The missionaries converted the Indian population
6. definition=score an extra point or points after touchdown by kicking the ball through the uprights or advancing the ball into the end zone | examples=Smith converted and his team won
7. definition=complete successfully | examples=score a penalty shot or free throw
8. definition=score (a spare)
9. definition=make (someone) agree, understand, or realize the truth or validity of something | examples=He had finally convinced several customers of the advantages of his product
10. definition=exchange a penalty for a less severe one
11. definition=change in nature, purpose, or function; undergo a chemical change | examples=The substance converts to an acid

reasoning_content:
The user wants me to identify which numbered sense of "convert" is used in the given sentence.

Let me analyze the sentence: "In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes that are involved in producing nucleotides..."

The key here is that pemetrexed (a substance/drug) is being changed into an active form. This is describing a chemical or biological transformation.

Now let me look at the senses:

1. Change from one system to another (like voltage) - not this one.
2. Change the nature, purpose, or function of something - this is close, but let me check others.
3. Change religious beliefs - not this.
4. Exchange or replace with another (currency) - not this.
5. Cause to adopt a new faith - not this.
6. Score points in sports - not this.
7. Complete successfully - not this.
8. Score a spare - not this.
9. Make someone agree - not this.
10. Exchange a penalty - not this.
11. Change in nature, purpose, or function; undergo a chemical change - examples: "The substance converts to an acid"

Sense 11 specifically mentions "undergo a chemical change" and the example is about a substance converting to something else. This matches perfectly with the sentence about pemetrexed being converted into an active form in the body (which is a chemical/biological process).

Sense 2 is also about changing nature/purpose/function, but sense 11 is more specific to chemical changes, which is exactly what's happening with a drug being metabolized or transformed in the body into an active form.

The sentence describes a chemical transformation of a substance (pemetrexed) into another form (active form). This is clearly sense 11.

Wait, let me double-check sense 2 vs sense 11:

Sense 2: "change the nature, purpose, or function of something | examples=convert lead into gold"
Sense 11: "change in nature, purpose, or function; undergo a chemical change | examples=The substance converts to an acid"

Both mention changing nature/purpose/function. But sense 11 specifically adds "undergo a chemical change" and the example involves a substance converting chemically.

The sentence is about a drug (pemetrexed) being converted in the body into an active form. This is a chemical/biological transformation. Sense 11 is the most precise fit because it explicitly mentions chemical change.

Actually, looking more carefully:
- Sense 2 example: "convert lead into gold" - this is also a chemical transformation (alchemical).
- Sense 11 example: "The substance converts to an acid" - this is explicitly chemical.

But sense 11's definition explicitly includes "undergo a chemical change" while sense 2 is more general about changing nature/purpose/function.

Given that the context is a biological/chemical process in the body (drug metabolism), sense 11 is the best match.

The answer should be 11.


[User]
Which numbered sense of "active" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. definition=engaged in or ready for military or naval operations | examples=on active duty
3. definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations
4. definition=taking part in an activity | examples=an active member of the club
5. definition=characterized by energetic activity | examples=an active toddler
6. definition=exerting influence or producing a change or effect | examples=an active ingredient
7. definition=full of activity or engaged in continuous activity | examples=an active seaport
8. definition=in operation | examples=keep hope alive
9. definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being
12. definition=(of e.g. volcanos) capable of erupting
13. definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. definition=engaged in full-time work | examples=active duty

reasoning_content:
The user wants me to identify which numbered sense of "active" is used in the given sentence.

Sentence: "In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides..."

The key context is that pemetrexed is converted into an "active" form that blocks enzyme activity. This means the form is exerting influence or producing a change/effect - it's biologically active, pharmacologically active.

Let me look at the senses:
1. tending to become more severe or wider in scope - no
2. engaged in military operations - no
3. disposed to take action - no, not about a person
4. taking part in an activity - no
5. characterized by energetic activity - no, not about being energetic
6. exerting influence or producing a change or effect - yes! "an active ingredient" is the example. This fits perfectly because the active form of the drug produces a biological effect (blocks enzymes).
7. full of activity - no
8. in operation - maybe, but less specific than 6
9. sun - no
10. grammar - no
11. verbs/participles - no
12. volcanos - no
13. volcanos - no
14. full-time work - no

Sense 6 is clearly the best fit: "exerting influence or producing a change or effect" with the example "an active ingredient". The sentence describes a drug being converted into its active form - this is standard pharmacological terminology where "active" means having a biological effect.

The answer should be just the number: 6.

provider: SiliconFlow


[User]
Which numbered sense of "form" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=the phonological or orthographic sound or appearance of a word that can be used to describe or identify something | examples=the inflected forms of a word can be represented by a stem and a list of inflections to be attached
2. definition=a category of things distinguished by some common characteristic or quality | examples=sculpture is a form of art
3. definition=a perceptual structure | examples=the composition presents problems for students of musical form
4. definition=any spatial attributes (especially as defined by outline) | examples=he could barely make out their shapes
5. definition=alternative names for the body of a human being | examples=Leonardo studied the human body
6. definition=the spatial arrangement of something as distinct from its substance | examples=geometry is the mathematical science of shape
7. definition=the visual appearance of something or someone | examples=the delicate cast of his features
8. definition=a printed document with spaces in which to write | examples=he filled out his tax form
9. definition=(biology) a group of organisms within a species that differ in trivial ways from similar groups | examples=a new strain of microorganisms
10. definition=an arrangement of the elements in a composition or discourse | examples=the essay was in the form of a dialogue
11. definition=a particular mode in which something is manifested | examples=his resentment took the form of extreme hostility
12. definition=(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary | examples=the reaction occurs in the liquid phase of the system
13. definition=a body of students who are taught together | examples=early morning classes are always sleepy
14. definition=an ability to perform well | examples=he was at the top of his form
15. definition=a life-size dummy used to display clothes
16. definition=a mold for setting concrete | examples=they built elaborate forms for pouring the foundation

reasoning_content:
The user wants me to identify which numbered sense of "form" is used in the given sentence.

The sentence is: "In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

Let me analyze the context:
- Pemetrexed is a drug/chemical compound
- It is converted into an "active form"
- This active form blocks enzyme activity
- This is talking about a chemical/biological conversion

Looking at the senses:

1. phonological or orthographic appearance of a word - No, this is about language/linguistics, not relevant here.

2. a category of things distinguished by some common characteristic - Could potentially fit, but let's check others.

3. a perceptual structure - No, this is about music or visual perception usually.

4. any spatial attributes - No, this is about physical shape/outline.

5. alternative names for the body of a human being - No, this is about anatomy.

6. the spatial arrangement of something as distinct from its substance - This is about shape/geometry.

7. the visual appearance of something - No.

8. a printed document - No.

9. (biology) a group of organisms within a species - This is about taxonomic groups, strains, variants of organisms.

10. an arrangement of the elements in a composition or discourse - This is about structure of writing/dialogue.

11. a particular mode in which something is manifested - This could work. "His resentment took the form of extreme hostility" - similar to "converted into an active form"

12. (physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary - This mentions "phase" and physical chemistry. The example mentions "liquid phase".

Wait, sense 12 mentions "phase" specifically. But in the sentence, we're talking about a drug being converted into an active form. In biochemistry/pharmacology, when we say a drug is converted into an "active form", we usually mean a chemical variant or state that is biologically active.

But let's look closely at sense 12: "a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary"

Actually, sense 12 seems to be about phases of matter (solid, liquid, gas). The example says "the reaction occurs in the liquid phase of the system."

But in the sentence, "pemetrexed is converted into an active form" - this sounds like it's being converted into a different chemical form or state. In pharmacology, "active form" often refers to a metabolite or a specific chemical state of the compound.

Let me reconsider sense 11: "a particular mode in which something is manifested" - example: "his resentment took the form of extreme hostility"

And sense 2: "a category of things distinguished by some common characteristic or quality" - example: "sculpture is a form of art"

Sense 9: biology group of organisms...

Actually, looking at sense 12 again: "(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary"

But pemetrexed being converted into an active form - this is likely talking about a chemical derivative or metabolite. However, looking at the definitions provided, sense 11 "a particular mode in which something is manifested" seems like it could apply to "active form" meaning the way the drug manifests its activity.

But wait, in chemistry/biology contexts, "form" can mean a particular chemical state or variant. Let me look at sense 12 again carefully.

Sense 12 mentions "phase boundary" and "physical chemistry". The sentence is about a drug (pemetrexed) being converted in the body. This is a biochemical process.

Actually, looking at WordNet or similar lexical databases (which these definitions seem to come from), sense 12 is specifically about "phase" in physical chemistry.

But "active form" in the context of enzymes and drugs often refers to the chemically active state or variant of the molecule.

Let me reconsider sense 2: "a category of things distinguished by some common characteristic or quality" - "sculpture is a form of art"

Sense 11: "a particular mode in which something is manifested" - "his resentment took the form of extreme hostility"

In the sentence: "pemetrexed is converted into an active form" - this means it changes into a different chemical species or state that is active.

Actually, looking at the definitions again, sense 12 might be the closest if we interpret "form" as a chemical state. But the definition mentions "phase boundary" and "physical state", which might not be exactly right if we're talking about a chemical derivative (like a metabolite).

However, in many lexical databases, sense 11 is often the one used for "form" meaning a type or kind or manifestation.

Let me think about the example in sense 11: "his resentment took the form of extreme hostility" - this is metaphorical.

But in the sentence, "converted into an active form" - this is literal. It's converted into a form (version/state) that is active.

Sense 2: "sculpture is a form of art" - this is about classification.

Sense 12: physical chemistry phase...

Actually, looking at the sentence more carefully: "pemetrexed is converted into an active form that blocks..."

In pharmacology, when we say a drug is converted into its "active form", we mean it undergoes a chemical transformation (like metabolism) to become the active compound.

But looking at the available senses, which one fits best?

Sense 11: "a particular mode in which something is manifested" - could fit, as the active form is the mode in which the drug manifests its activity.

Sense 2: "a category of things..." - less likely.

Sense 12: physical chemistry state of matter - might be too specific to phases (solid/liquid/gas).

Wait, I should check if there's a sense about chemical forms or biological forms.

Sense 9 is about biological taxonomy (strains).

Sense 12 is about physical chemistry phases.

Sense 11 seems to be the most general: "a particular mode in which something is manifested"

But let me look at sense 2 again: "a category of things distinguished by some common characteristic or quality"

Actually, looking at standard WordNet senses for "form":

In WordNet 3.0 or similar:
- Sense 1: shape, form, configuration...
- Sense 2: form, kind, sort...
- Sense 3: form, shape, cast...
- Sense 4: form, phase...
- Sense 5: form, word form...
- Sense 6: form, manifestation...
- etc.

Wait, looking at the provided list:
1. phonological...
2. category...
3. perceptual structure...
4. spatial attributes...
5. human body...
6. spatial arrangement...
7. visual appearance...
8. printed document...
9. biology group...
10. arrangement of elements...
11. particular mode...
12. physical chemistry state...
13. body of students...
14. ability to perform...
15. life-size dummy...
16. mold...

Sense 11: "a particular mode in which something is manifested" with example "his resentment took the form of extreme hostility"

Sense 12: "(physical chemistry) a distinct state of matter in a system..." with example mentioning "liquid phase"

In the sentence, "converted into an active form" - this is similar to "took the form of" in sense 11. The drug takes on an active form (manifestation).

However, in chemical contexts, "form" can mean a specific chemical species or state. But given the options, sense 11 seems most appropriate because:
1. It's about how something is manifested (the active manifestation of the drug)
2. The structure "converted into an X form" is similar to "took the form of"

But wait, sense 2: "a category of things distinguished by some common characteristic or quality" - could "active form" be a category? No, that doesn't fit well.

Sense 12 is specifically about physical chemistry phases (solid, liquid, gas). While drugs can be in different phases, "active form" usually refers to the chemical structure or biological activity, not the phase of matter.

Actually, looking at the sentence again, it's talking about pemetrexed being converted into an active form that blocks enzymes. This is definitely about the chemical/metabolic conversion of the drug into its active metabolite or active chemical state.

But among the given options, sense 11 "a particular mode in which something is manifested" seems the best fit because the active form is a particular mode/state in which the substance exists.

However, I should consider if sense 2 could apply. "Sculpture is a form of art" - here "form" means a type or kind. "An active form" could mean an active type, but that seems less likely than a mode of manifestation.

Let me reconsider sense 12. The definition says: "(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary"

If pemetrexed is converted into an active form, and if that means it's converted into a different chemical compound (metabolite), then it's not the same chemical composition, so sense 12 wouldn't apply because sense 12 requires "identical in chemical composition".

Therefore, sense 12 is out.

Sense 11: "a particular mode in which something is manifested" - this is very general and can apply to the drug existing in an active mode/state.

Sense 2: "a category of things..." - this is about classification, not about a specific instance of a drug being converted.

Sense 9: biology group of organisms - not applicable.

Sense 10: arrangement of elements in composition - not applicable.

So sense 11 seems correct.

But let me double-check by searching my internal knowledge of how "form" is used in similar contexts. In pharmacology, "active form" is commonly used to describe the state or chemical species of a drug that has biological activity. This aligns with "mode of manifestation".

For example, "The drug is converted in the liver to its active form." This is standard pharmaceutical terminology.

Sense 11 is the best match.

Wait, I should also consider sense 2 again. Could "active form" mean "active type"? Like "this is a form of therapy"? But the sentence says "converted into an active form", implying a change of state or manifestation, not classification into a category.

Therefore, the answer is 11.

provider: ModelRun


[User]
Which numbered sense of "block" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the body, pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=render unsuitable for passage | examples=block the way
2. definition=hinder or prevent the progress or accomplishment of | examples=His brother blocked him at every turn
3. definition=stop from happening or developing | examples=Block his election
4. definition=interfere with or prevent the reception of signals | examples=Jam the Voice of America
5. definition=run on a block system | examples=block trains
6. definition=interrupt the normal function of by means of anesthesia | examples=block a nerve
7. definition=shut out from view or get in the way so as to hide from sight | examples=The thick curtain blocked the action on the stage
8. definition=stamp or emboss a title or design on a book with a block | examples=block the book cover
9. definition=obstruct | examples=My nose is all stuffed
10. definition=block passage through | examples=obstruct the path
11. definition=support, secure, or raise with a block | examples=block a plate for printing
12. definition=impede the movement of (an opponent or a ball) | examples=block an attack
13. definition=be unable to remember | examples=I'm drawing a blank
14. definition=shape by using a block | examples=Block a hat
15. definition=shape into a block or blocks | examples=block the graphs so one can see the results clearly
16. definition=prohibit the conversion or use of (assets) | examples=Blocked funds

reasoning_content:
 The user wants me to identify which numbered sense of "block" is used in the given sentence. Let me analyze the sentence and the definitions.

Sentence: "In the body, pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides..."

The key context here is that pemetrexed "blocks the activity of enzymes." This means it prevents or hinders the enzymes from functioning or carrying out their normal activity.

Let me look at the definitions:

1. render unsuitable for passage - This is about physical blocking of a path/way. Not quite right.
2. hinder or prevent the progress or accomplishment of - This could work. It hinders the activity of enzymes.
3. stop from happening or developing - This could also work. It stops the activity.
4. interfere with or prevent the reception of signals - This is about signals/jamming. Not applicable.
5. run on a block system - This is about trains. Not applicable.
6. interrupt the normal function of by means of anesthesia - This is specifically about anesthesia and nerves. The sentence is about enzymes, not anesthesia.
7. shut out from view or get in the way so as to hide from sight - This is about visual blocking. Not applicable.
8. stamp or emboss - Not applicable.
9. obstruct - This is general. "My nose is all stuffed" - this is about physical obstruction.
10. block passage through - This is about physical passage. Not quite right for enzyme activity.
11. support, secure, or raise with a block - Physical support. Not applicable.
12. impede the movement of (an opponent or a ball) - Sports context. Not applicable.
13. be unable to remember - Mental block. Not applicable.
14. shape by using a block - Physical shaping. Not applicable.
15. shape into a block or blocks - Not applicable.
16. prohibit the conversion or use of (assets) - Financial context. Not applicable.

Now between 2, 3, and possibly 6 or 9.

Definition 6 says "interrupt the normal function of by means of anesthesia" - the example is "block a nerve". This is close, but the sentence doesn't mention anesthesia, and it's about enzymes, not nerves.

Definition 2: "hinder or prevent the progress or accomplishment of" - example: "His brother blocked him at every turn"
Definition 3: "stop from happening or developing" - example: "Block his election"

The sentence says "blocks the activity of the enzymes" - this means it prevents the enzymes from functioning or hinders their function.

Looking at definition 6 again: "interrupt the normal function of by means of anesthesia" - this is specifically about anesthesia. But the word "block" in medical contexts often refers to blocking nerve signals or enzyme activity.

However, looking at the specific wording: "interrupt the normal function of" - this matches perfectly with blocking enzyme activity. But the "by means of anesthesia" part is specific.

Wait, let me reconsider. The sentence is about biochemistry - blocking enzyme activity. This is a common usage in pharmacology.

Definition 2: hinder or prevent the progress or accomplishment of
Definition 3: stop from happening or developing
Definition 6: interrupt the normal function of by means of anesthesia

Actually, looking more carefully at definition 6: "interrupt the normal function of by means of anesthesia" - the phrase "by means of anesthesia" might be part of the definition or just the context of the example. Let me read it again.

"6. definition=interrupt the normal function of by means of anesthesia | examples=block a nerve"

This definition seems specifically about anesthesia and nerves. The example "block a nerve" is a medical term, but it's specifically about anesthesia.

But in biochemistry, when we say a drug "blocks" an enzyme, we mean it inhibits the enzyme - it hinders or prevents the enzyme from functioning.

Let me look at definition 9: "obstruct | examples=My nose is all stuffed"
And definition 10: "block passage through | examples=obstruct the path"

These are more physical.

Definition 2 seems like the best fit: "hinder or prevent the progress or accomplishment of"
Definition 3: "stop from happening or developing"

"Block his election" - this is preventing an event.
"Block the activity of enzymes" - this is preventing/hindering the activity.

Actually, looking at WordNet or similar lexical databases, the sense of "block" meaning to inhibit or prevent the function of something (like an enzyme or receptor) is often distinct.

But given the options, I need to choose the best match.

Definition 6 mentions "interrupt the normal function of" which is exactly what happens to enzymes when they are blocked. However, it specifies "by means of anesthesia" which doesn't fit.

Wait, I should check if "block" in the medical sense of enzyme inhibition matches any of these.

Definition 2: hinder or prevent the progress or accomplishment of
- This is quite general and could apply.

Definition 3: stop from happening or developing
- This is also possible.

But let me look at the examples more carefully.

Definition 6 example: "block a nerve" - this is very similar to "block the activity of enzymes" - both are about blocking biological functions. Even though the definition mentions anesthesia, the core meaning is "interrupt the normal function of."

However, the phrase "by means of anesthesia" is problematic because pemetrexed is not an anesthetic.

Let me reconsider definition 2: "hinder or prevent the progress or accomplishment of" - example: "His brother blocked him at every turn"
This is about hindering someone's progress or efforts.

Definition 3: "stop from happening or developing" - example: "Block his election"
This is about preventing an event.

Definition 9: "obstruct" - example: "My nose is all stuffed"
This is about physical obstruction.

Actually, looking at the sentence again: "blocks the activity of the enzymes"
This is about inhibiting or preventing the function/activity.

In many lexical databases, "block" when used with enzymes, receptors, etc., falls under the sense of obstructing, hindering, or preventing function.

Between definitions 2, 3, and 6:
- Definition 6 is the closest in meaning (interrupt normal function) but is too specific with "anesthesia"
- Definition 2 is about hindering progress/accomplishment
- Definition 3 is about stopping from happening

Actually, looking at standard dictionary definitions:
- Block can mean to stop or hinder the movement, progress, or action of something
- In biochemistry, to inhibit or stop the activity of an enzyme

Definition 2 says "hinder or prevent the progress or accomplishment of"
Definition 3 says "stop from happening or developing"

"Block the activity" - activity is a process. Blocking a process is hindering or preventing it.

But wait, I need to be more careful. The question asks which numbered sense marked with <t></t> is used.

Let me look at definition 6 once more: "interrupt the normal function of by means of anesthesia"
Is it possible that "by means of anesthesia" is just clarifying the example, not limiting the definition? Or is it part of the definition?

The format is: "definition=interrupt the normal function of by means of anesthesia | examples=block a nerve"

This suggests the definition includes "by means of anesthesia." So this would be specifically about anesthesia.

But "block a nerve" without anesthesia context is also a medical term. However, the definition explicitly mentions anesthesia.

Let me look for a better fit.

Definition 2: hinder or prevent the progress or accomplishment of
This seems like the most general and appropriate definition for blocking enzyme activity. The enzyme has a function/activity, and the drug hinders or prevents that activity from being accomplished.

Definition 3 is about stopping something from happening or developing, like an election. While enzymes are involved in a process (producing nucleotides), the direct object is "the activity" not the production itself.

Actually, the sentence says "blocks the activity of the enzymes"
And definition 6 says "interrupt the normal function of"

"Activity" and "function" are synonyms here.
"Block" and "interrupt" are similar.

But definition 6 is limited to anesthesia.

Hmm, let me reconsider whether "by means of anesthesia" is part of the definition or just context. In WordNet-style definitions, sometimes the definition is specific.

Actually, looking at the list again, I see definition 9: "obstruct" with example "My nose is all stuffed"
And definition 10: "block passage through"

Definition 2 seems most likely: hinder or prevent the progress or accomplishment of.

But let me think about this more. In pharmacology, when we say a drug "blocks" an enzyme, we are using the sense of "inhibit" or "prevent from functioning."

Looking at the options, definition 6 "interrupt the normal function of" is semantically the closest, despite the anesthesia specification. However, that specification makes it wrong.

Wait - I should check if there's a definition about chemical or biological blocking.

Definition 2: hinder or prevent the progress or accomplishment of
Example: His brother blocked him at every turn

Definition 3: stop from happening or developing
Example: Block his election

Definition 9: obstruct
Example: My nose is all stuffed

Actually, "obstruct" (definition 9) with the example of a stuffed nose is about blocking airflow - a physiological blocking. This is close.

But "My nose is all stuffed" - this is about physical blockage of a passage.

For enzymes, it's not a physical passage being blocked, but an chemical activity being inhibited.

Let me reconsider definition 6. In medical terminology, "block" often means to interrupt function, especially of nerves. But enzymes are not nerves.

However, the mechanism is similar - preventing the normal function.

But the definition explicitly says "by means of anesthesia." Pemetrexed is a chemotherapy drug, not an anesthetic.

So definition 6 is out.

Between 2 and 3:
Definition 2: hinder or prevent the progress or accomplishment of
Definition 3: stop from happening or developing

"Block the activity" - activity is ongoing. You hinder or prevent it.
"Block his election" - prevent an event from occurring.
"Block him at every turn" - hinder his progress/actions.

I think definition 2 is the best fit.

But let me double check definition 9: "obstruct"
In many dictionaries, "block" meaning to inhibit enzyme activity is a specific sense. But here, looking at the definitions provided:

Actually, looking at definition 6 again, I wonder if I should interpret "interrupt the normal function of by means of anesthesia" as two separate things or if "by means of anesthesia" applies only to the example.

The format is: definition=X | examples=Y

So X is "interrupt the normal function of by means of anesthesia"
Y is "block a nerve"

This means the definition of sense 6 is specifically about interrupting function via anesthesia.

For enzymes, we need a different sense.

Definition 2: hinder or prevent the progress or accomplishment of
This is sense 2.

Let me see if there's any other sense that fits.
Definition 12: impede the movement of (an opponent or a ball) - sports
Definition 4: interfere with or prevent the reception of signals - jamming

Actually, definition 4 is about signals. Enzymes don't receive signals in the sense of radio signals.

Definition 2 is the most general: hinder or prevent the progress or accomplishment of.
The activity of enzymes is their function/progress in catalyzing reactions. Blocking this activity means hindering or preventing it.

I think the answer is 2.

Wait, I want to check one more time. Is there a sense about inhibiting chemical reactions?

Definition 3: stop from happening or developing
This could work for "block the production of nucleotides" but the sentence says "blocks the activity of the enzymes."

Actually, looking at the sentence structure:
"blocks the activity of the enzymes that are involved in producing nucleotides"

So it blocks the activity.

In WordNet 3.0, the senses of block include:
1. block, obstruct - hinder or prevent the progress or accomplishment of
2. stop, block, halt, kibosh - stop from happening or developing
3. stop, halt, block, contain - render unsuitable for passage
...

Sense 1 matches definition 2 here.
Sense 2 matches definition 3 here.

For "block enzyme activity," this is typically sense 1 - to hinder or prevent the function/progress of the enzyme.

Actually, looking up "block" in a medical dictionary or usage:
"Block (verb): To obstruct, hinder, or prevent the normal function of a process, substance, or structure."

Given the choices, definition 2 "hinder or prevent the progress or accomplishment of" is the best match.

Definition 6 is too specific with anesthesia.
Definition 3 is about stopping events from happening.
Definition 2 is about hindering progress or accomplishment, which fits enzyme activity.

The answer should be 2.

But I want to be absolutely sure. Let me look at the example for definition 2: "His brother blocked him at every turn"
This means hindered his progress or prevented him from accomplishing his goals.

For enzymes, the drug blocks (hinders/prevents) the activity (the accomplishment of their function).

Yes, 2 is correct.

Actually, one more check: could it be definition 6?
"interrupt the normal function of by means of anesthesia"
Even though it mentions anesthesia, is it possible that "block a nerve" is the key, and blocking enzyme activity is similar to blocking nerve function?

But the definition explicitly includes "by means of anesthesia." Since pemetrexed is not an anesthetic, this sense doesn't fit.

Could it be definition 9 "obstruct"?
Example: "My nose is all stuffed"
This is about physical obstruction.

Enzyme blocking is not physical obstruction in the same way. It's chemical inhibition.

Definition 2 is the abstract sense of hindering or preventing progress/accomplishment.

I think 2 is the answer.

Actually, looking at similar questions or standard lexical semantic analysis, when a drug blocks an enzyme, it's usually sense 2 or a specific biochemical sense. Since the specific biochemical sense isn't listed with the right definition, and definition 6 is limited to anesthesia, definition 2 is the best choice.

Wait, I want to look at definition 3 again: "stop from happening or developing"
Example: "Block his election"
This is preventing an event.

Is enzyme activity an event? It's a process. You can stop a process from happening.

But "hinder or prevent the progress" (def 2) seems more appropriate for an ongoing activity.

Also, the word "activity" suggests something ongoing that is being hindered.

I'll go with 2.


[User]
Which numbered sense of "involved" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved
2. definition=entangled or hindered as if e.g. in mire | examples=the difficulties in which the question is involved
3. definition=emotionally involved
4. definition=highly complex or intricate and occasionally devious; ; ; ; ; ; ; ; - Sir Walter Scott | examples=the Byzantine tax structure
5. definition=enveloped | examples=a castle involved in mist

reasoning_content:
The user wants me to identify which numbered sense of "involved" is used in the given sentence.

Let me analyze the sentence:
"In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

The word "involved" here means participating in or taking part in the process of producing nucleotides. The enzymes are participating/associated in the process of producing nucleotides.

Now let's look at the senses:
1. definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved
2. definition=entangled or hindered as if e.g. in mire | examples=the difficulties in which the question is involved
3. definition=emotionally involved
4. definition=highly complex or intricate and occasionally devious; ; ; ; ; ; ; ; - Sir Walter Scott | examples=the Byzantine tax structure
5. definition=enveloped | examples=a castle involved in mist

Sense 1 fits best: "connected by participation or association or use". The enzymes are participating in/associated with the process of producing nucleotides.

Sense 2 is about being entangled or hindered.
Sense 3 is about emotional involvement.
Sense 4 is about complexity (like "an involved explanation").
Sense 5 is about being enveloped (literally surrounded).

The sentence is talking about enzymes that participate in/are associated with a biological process. This matches sense 1.

I should return only the number.


[User]
Which numbered sense of "produce" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in <t>producing</t> nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Senses:
1. definition=bring forth or yield | examples=The tree would not produce fruit
2. definition=create or manufacture a man-made product | examples=We produce more cars than we can sell
3. definition=cause to happen, occur or exist | examples=This procedure produces a curious effect
4. definition=bring out for display | examples=The proud father produced many pictures of his baby
5. definition=cultivate by growing, often involving improvements by means of agricultural techniques | examples=The Bordeaux region produces great red wines
6. definition=bring onto the market or release | examples=produce a movie
7. definition=come to have or undergo a change of (physical features and attributes) | examples=He grew a beard

reasoning_content:
 The user wants me to identify which numbered sense of "produce" is used in the given sentence.

Sentence: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in <t>producing</t> nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

Let me analyze the context:
- The sentence is talking about enzymes being involved in producing nucleotides
- Nucleotides are building blocks of DNA and RNA
- This is a biological/cellular process
- Enzymes are producing (creating/manufacturing) nucleotides

Now let's look at the senses:

1. "bring forth or yield" - The tree would not produce fruit. This is more about natural yield, like fruit from trees.
2. "create or manufacture a man-made product" - We produce more cars than we can sell. This is about manufacturing/creating something.
3. "cause to happen, occur or exist" - This procedure produces a curious effect. This is about causing an effect/outcome.
4. "bring out for display" - The proud father produced many pictures of his baby. This is about presenting/showing something.
5. "cultivate by growing, often involving improvements by means of agricultural techniques" - The Bordeaux region produces great red wines. This is agricultural production.
6. "bring onto the market or release" - produce a movie. This is about releasing/publishing.
7. "come to have or undergo a change of (physical features and attributes)" - He grew a beard. This is about growing/changing.

In the sentence, enzymes are involved in producing nucleotides. Nucleotides are biological molecules. The enzymes are creating/manufacturing these molecules in the body.

However, looking closely:
- Sense 2 mentions "create or manufacture a man-made product" - but nucleotides are natural biological molecules, not man-made.
- Sense 1 mentions "bring forth or yield" - this could apply to biological processes.
- Sense 3 mentions "cause to happen, occur or exist" - enzymes cause nucleotides to be formed/exist.

Wait, let me reconsider. In biological contexts, when we say enzymes produce nucleotides, we mean they catalyze the creation/synthesis of nucleotides.

Looking at the examples:
- Sense 1: "The tree would not produce fruit" - natural biological production
- Sense 2: "We produce more cars than we can sell" - artificial/manufactured production
- Sense 3: "This procedure produces a curious effect" - causing an outcome

In biological contexts, especially with enzymes and biochemical compounds like nucleotides, "produce" usually means to bring forth, yield, or create through biological processes.

But sense 2 says "create or manufacture a man-made product" - the key here is "man-made". Nucleotides in the body are not man-made.

Sense 1: "bring forth or yield" - This is broader and can apply to biological processes like enzymes yielding/producing nucleotides.

Sense 5 is specifically about agricultural cultivation.

Actually, looking at WordNet or similar lexicographical resources (which these senses seem to be derived from), sense 2 might be the general "create or manufacture" sense, but the "man-made" in the definition might be restricting it.

Let me think about the specific context again: "enzymes that are involved in producing nucleotides"

Enzymes catalyze the production of nucleotides. They bring them into existence or cause them to be formed.

Sense 3: "cause to happen, occur or exist" - This could fit because the enzymes cause nucleotides to exist/be formed.

Sense 1: "bring forth or yield" - This also fits, as the enzymes yield nucleotides as a product.

But looking at the examples:
- Sense 1 example: "The tree would not produce fruit" - biological, natural
- Sense 2 example: "We produce more cars than we can sell" - industrial, manufacturing
- Sense 3 example: "This procedure produces a curious effect" - causing an abstract effect

Nucleotides are chemical compounds. When enzymes produce nucleotides, they are synthesizing them. This is closer to manufacturing/creating (sense 2) than yielding fruit (sense 1), but nucleotides aren't "man-made" in the sense of industrial manufacturing.

However, in many lexical databases, sense 2 is the general "create" sense for products, while sense 1 is specific to natural yield (plants, animals).

Actually, looking carefully at the definitions:
1. bring forth or yield (like fruit, offspring)
2. create or manufacture a man-made product (industrial production)
3. cause to happen, occur or exist (causative)

In biochemistry, when we say enzymes produce nucleotides, we could argue it's closest to sense 2 (create) but without the "man-made" restriction necessarily applying, OR sense 1 (bring forth/yield) because it's a biological process like a tree producing fruit.

But wait - the enzyme isn't the organism itself, it's a catalyst. The enzyme helps in the process of creating nucleotides.

Let me reconsider sense 3: "cause to happen, occur or exist". The enzymes cause nucleotides to exist/be formed. This seems plausible.

But actually, in standard dictionary definitions for "produce" in biological contexts (enzymes producing compounds), it usually falls under the "make, manufacture" sense or the "bring forth" sense.

Looking at the specific wording of sense 2: "create or manufacture a man-made product" - the addition of "man-made" seems to rule out biological molecules created by enzymes.

Sense 1: "bring forth or yield" - this is used for crops, offspring, natural products.

Sense 3: "cause to happen, occur or exist" - this is used for effects, outcomes, changes.

I think the best fit is actually sense 2, interpreting "man-made" broadly, OR sense 1 interpreting enzymes as agents that yield products.

But looking at the exact sentence structure: "enzymes that are involved in producing nucleotides" - this is about biochemical synthesis.

Let me check if these senses align with WordNet. The definitions look like they could be from WordNet 3.0 or similar:

WordNet 3.0 senses for "produce" (verb):
1. bring forth or yield - "The tree would not produce fruit"
2. produce, make, create - "The company has been making cars for over a century" / "We produce more cars than we can sell"
3. produce, bring about, give rise - "This procedure produces a curious effect"
4. produce, bring forth - "The proud father produced many pictures of his baby"
5. grow, raise, farm, produce - "The Bordeaux region produces great red wines"
6. produce, bring on, bring out - "produce a movie"
7. grow, develop, produce... - "He grew a beard"

Wait, sense 7 in WordNet is actually about growing/developing (like growing a beard), which matches the user's sense 7.

Sense 2 in WordNet is "create or manufacture a man-made product".

In the sentence, nucleotides are the end product of enzymatic reactions. The enzymes catalyze their production. This is biological synthesis.

In many contexts, "produce" for enzymes making molecules is sense 2 (create, make), even if the molecules are natural. The "man-made" in the definition might be misleading, or it might be distinguishing from natural growth (sense 1) and cultivation (sense 5).

Actually, looking at sense 1 vs sense 2 distinction:
- Sense 1: natural yield (fruit, crops by nature)
- Sense 2: manufacturing (cars, goods by humans)
- Sense 5: cultivation (wine, crops by agriculture)

For enzymes producing nucleotides, this is biochemical manufacturing/synthesis. It's closest to sense 2, but arguably sense 1 could also fit if we consider biological production as "bringing forth."

However, looking at the examples given:
- Sense 1: "The tree would not produce fruit" - natural biological process, organism produces part of itself or its offspring/fruit
- Sense 2: "We produce more cars than we can sell" - artificial manufacturing

Enzymes are part of the body, and they catalyze the production of nucleotides. This is similar to how the body produces chemicals. The body produces nucleotides (via enzymes).

If I say "the body produces enzymes", that's sense 1 (natural yield).
If I say "the factory produces cars", that's sense 2.
If I say "the enzyme produces nucleotides", it's ambiguous between 1 and 2, but since nucleotides are chemical compounds being synthesized, and sense 2 specifically mentions "man-made", and nucleotides are not man-made but natural...

Actually, in the sentence, is it the enzymes producing nucleotides, or is the process producing them? "enzymes that are involved in producing nucleotides" - it's the process involving enzymes that produces them.

I think the intended answer is likely sense 2 (create/manufacture) or sense 1 (bring forth).

But let me look at the exact wording again. The sentence is about drug action (pemetrexed). It blocks enzymes involved in producing nucleotides. This is inhibiting DNA/RNA synthesis.

In technical biological contexts, "produce" here means "synthesize" or "create", which maps to sense 2, despite the "man-made" qualification, OR it maps to sense 3 (cause to exist).

But sense 3 example is "This procedure produces a curious effect" - an abstract effect, not a physical thing like nucleotides.

Sense 1 is physical things (fruit).
Sense 2 is physical products (cars).
Sense 3 is abstract effects or events.

Nucleotides are physical molecules, so sense 3 is less likely.

Between 1 and 2:
- Fruit is organic, grown
- Cars are manufactured, artificial

Nucleotides are organic molecules synthesized by enzymes. This is biosynthesis, which is closer to manufacturing (chemical synthesis) than to natural yielding (like fruit).

However, many dictionaries would group biological synthesis under "bring forth or yield" (sense 1) if it's a natural process, or under specific biochemical definitions.

But looking at the provided options, and considering that "produce" in the context of enzymes and biochemical pathways is typically the "create/manufacture" sense, I think the answer is 2.

Wait, I should reconsider sense 1. "Bring forth or yield" - this is often used for children, fruit, results. "Produce nucleotides" could be "yield nucleotides."

But I recall that in some lexical semantic datasets (like the ones used in WSD tasks), the sense distinctions are:
1. yield, give (natural)
2. make, create (manufactured)
3. bring about (cause)

For the specific case of enzymes producing compounds, let's think about parallel examples:
- "The liver produces bile." -> Sense 1 (natural organ function) or 2?
- "The factory produces widgets." -> Sense 2
- "The plant produces oxygen." -> Sense 1 (natural)

Enzymes are analogous to the liver or the plant - natural biological entities. So sense 1 might be correct.

But enzymes are also catalysts... they facilitate the reaction that produces nucleotides.

Let me check if there's a standard answer for this type of sentence. This looks like it could be from a Word Sense Disambiguation (WSD) dataset, like SemCor or similar.

The sentence mentions "the body", "pemetrexed" (a drug), "enzymes", "nucleotides", "DNA and RNA".

This is definitely biological synthesis.

Given the choices, and that sense 5 is specifically agricultural, and sense 7 is about growing features, and sense 4 is about displaying, and sense 6 is about releasing movies, that leaves 1, 2, 3.

Between 1, 2, and 3:
- 3 is unlikely because nucleotides are tangible products, not effects/events (though "produce an effect" is idiom)
- 1 vs 2: The distinction is natural vs artificial.

Since this is inside the body, natural biological process, sense 1 seems most appropriate.

But I'm worried about the "man-made" in sense 2. If the test is from a specific source that uses these definitions, I need to see which one fits.

Actually, looking at the definition of sense 2 again: "create or manufacture a man-made product". This is very specific to human manufacturing.

Nucleotides are not man-made in this context; they are made by the body. So sense 2 is ruled out by the definition.

Sense 1: "bring forth or yield". Enzymes yield nucleotides. This fits.

Sense 3: "cause to happen, occur or exist". Enzymes cause nucleotides to exist.

Between 1 and 3, sense 1 is more concrete (bring forth a thing), sense 3 is more abstract (cause to exist).

Also, "produce nucleotides" in biology is standard terminology for biosynthesis, which is like yielding a product.

I think the answer is 1.

But let me double-check. Could it be 2? Some might argue that synthesis is manufacturing. But the definition explicitly says "man-made".

Could it be 3? "Cause to exist" is philosophically true but in dictionary definitions, "produce" for physical goods is usually sense 1 or 2.

Given "The tree would not produce fruit" as the example for sense 1, and enzymes in the body producing nucleotides being analogous to a tree producing fruit (natural biological production), the answer should be 1.

However, I recall that in some classification systems, "produce" for chemical compounds (even by the body) is considered sense 2 (create).

But the definition "create or manufacture a man-made product" vs "bring forth or yield" is the key.

"Bring forth" is used for: show, fruit, young (biology)
"Create or manufacture" is used for: cars, goods (industry)

Nucleotides are biochemicals, so "bring forth" is better.

Also, note that sense 5 is "cultivate by growing", which is agricultural.

Therefore, my final answer is 1.

Wait, one more thought: In the sentence "enzymes that are involved in producing nucleotides", the word "producing" is a gerund/participle. The enzymes participate in the process of production.

Is there any chance it's sense 3? "Cause to happen"? No, nucleotides don't "happen" or "occur" as events; they exist as substances.

Therefore, sense 1 is the best fit.

Actually, looking at similar WSD examples online or in datasets...
For example, in SemCor:
"produce" sense 1: "produce young", "produce fruit", "produce grain"
"produce" sense 2: "produce steel", "produce goods", "produce automobiles"

Given that nucleotides are molecules produced by biochemical processes (like grain or fruit produced by biological processes), sense 1 is correct.

Final answer: 1


[User]
Which numbered sense of "building_block" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the <t>building blocks</t> of DNA and RNA, the genetic material of cells).

Senses:
1. definition=a single undivided natural thing occurring in the composition of something else | examples=units of nucleic acids
2. definition=a block of material used in construction work

reasoning_content:
 The user wants me to identify which sense of "building_block" is used in the given sentence. The sentence is: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the <t>building blocks</t> of DNA and RNA, the genetic material of cells)."

The two senses provided are:
1. definition=a single undivided natural thing occurring in the composition of something else | examples=units of nucleic acids
2. definition=a block of material used in construction work

Let me analyze the context:
- The sentence talks about nucleotides being the "building blocks" of DNA and RNA
- DNA and RNA are genetic material
- Nucleotides are molecular units that make up DNA and RNA
- This fits sense 1: "a single undivided natural thing occurring in the composition of something else" with the example "units of nucleic acids"

Sense 2 refers to physical construction materials (like bricks, concrete blocks, etc.), which doesn't fit the biological context of DNA/RNA.

Therefore, the correct answer is 1.


[User]
Which numbered sense of "genetic" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the <t>genetic</t> material of cells).

Senses:
1. definition=occurring among members of a family usually by heredity | examples=an inherited disease
2. definition=of or relating to or produced by or being a gene | examples=genic combinations
3. definition=pertaining to or referring to origin | examples=genetic history reconstructs the origins of a literary work
4. definition=of or relating to the science of genetics | examples=genetic research

reasoning_content:
 The user wants me to identify which numbered sense of "genetic" is used in the given sentence.

 The sentence is: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the <t>genetic</t> material of cells)."

 The word "genetic" here describes "material of cells" referring to DNA and RNA.

 Let's look at the senses:
 1. occurring among members of a family usually by heredity (e.g., inherited disease) - This refers to hereditary traits passed down in families.
 2. of or relating to or produced by or being a gene (e.g., genic combinations) - This refers to genes specifically.
 3. pertaining to or referring to origin (e.g., genetic history reconstructs origins) - This is about etymology or origins.
 4. of or relating to the science of genetics (e.g., genetic research) - This refers to the field of study.

 In the sentence, "genetic material" refers to DNA and RNA, which are the molecules that carry genetic information (genes). DNA and RNA are the material that contains genes or is related to genes.

 Sense 2 mentions "of or relating to or produced by or being a gene" - DNA and RNA are the material that contains genes, or is produced by genes/is the physical manifestation of genetic information. DNA is the genetic material because it is made of genes (or contains genes).

 Actually, let me reconsider. "Genetic material" typically refers to DNA and RNA, which carry the genetic information.

 Sense 2: "of or relating to or produced by or being a gene" - DNA and RNA consist of genes (or are composed of genes/sequences that constitute genes). The genetic material is the material of the genes, i.e., relating to genes.

 Sense 4: "of or relating to the science of genetics" - This would be like "genetic research" or "genetic testing" - things related to the study, not the physical material itself.

 Sense 1: Hereditary - This is about family inheritance.

 Sense 3: Origin - This is about etymology or historical origins.

 In the context "DNA and RNA, the genetic material of cells", this is referring to the molecules that contain the genetic information (genes). So this is most likely sense 2: relating to genes, or sense 4?

 Actually, looking at dictionary definitions:
 - "Genetic material" means the material that carries genetic information, i.e., DNA and RNA.

 WordNet or similar dictionaries often define "genetic" in relation to genes:
 - Pertaining to genetics or genes
 - Of or relating to or produced by or being a gene (sense 2)

 But let me look at the specific wording again:
 "the building blocks of DNA and RNA, the genetic material of cells"

 DNA and RNA are described as the genetic material. This means the material that pertains to genes/heredity.

 Sense 2 seems to fit best: "of or relating to or produced by or being a gene" - because DNA/RNA is the material that constitutes/contains genes.

 Sense 4 is about the science of genetics (the field of study).

 The material itself (DNA/RNA) is genetic material because it is the physical substance of the genes, or related to genes.

 Actually, looking at examples:
 - Sense 2 examples: "genic combinations" - this is clearly about genes.
 - Sense 4 examples: "genetic research" - clearly about the field.

 Is "genetic material" referring to the field of study (sense 4) or to genes themselves (sense 2)?

 Clearly, it's referring to genes. The material contains the genes. So sense 2.

 Wait, but I should verify. In some dictionaries, "genetic material" might fall under the general definition of genetics (the science).

 But usually:
 - Genetic code: the code of genes (sense 2)
 - Genetic material: the material of genes (sense 2)
 - Genetic engineering (sense 4 - technique/science)
 - Genetic disease (sense 1 - hereditary)

 "Genetic material" is the material that comprises genes or carries genetic information, so sense 2.

 Let me double-check by considering if it could be sense 1 (heredity). DNA/RNA are the materials of heredity, so one could argue sense 1. But sense 1 specifically mentions "occurring among members of a family usually by heredity" and the example is "an inherited disease". This is about hereditary traits in families, not the molecular material itself.

 Sense 2 connects directly to "gene".

 Sense 4 is the science.

 So the answer should be 2.

 But wait, looking at typical dictionary entries for "genetic":
 1. relating to genes or heredity
 2. relating to the origin or development of something
 3. relating to genetics (the science)

 The provided sense 1 is specifically about heredity/family inheritance ("occurring among members of a family usually by heredity").
 The provided sense 2 is specifically about genes ("being a gene").
 The provided sense 3 is about origin ("genetic history").
 The provided sense 4 is about the science ("genetic research").

 In "genetic material", DNA and RNA are the substances that store genetic information. They are the material that consists of genes. So this is sense 2.

 Therefore, the answer is 2.


[User]
Which numbered sense of "material" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic <t>material</t> of cells).

Senses:
1. definition=the tangible substance that goes into the makeup of a physical object | examples=coal is a hard black material
2. definition=information (data or ideas or observations) that can be used or reworked into a finished form | examples=the archives provided rich material for a definitive biography
3. definition=artifact made by weaving or felting or knitting or crocheting natural or synthetic fibers | examples=the fabric in the curtains was light and semitransparent
4. definition=things needed for doing or making something | examples=writing materials
5. definition=a person judged suitable for admission or employment | examples=he was university material

reasoning_content:
The user wants me to identify which numbered sense of "material" is used in the given sentence. The target word is marked with <t></t> tags.

Sentence: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic <t>material</t> of cells)."

Let's look at the context. The word "material" here refers to "genetic material" - meaning the substance that makes up genes, DNA and RNA. It's referring to the physical substance that constitutes the genetic makeup of cells.

Now let's evaluate the senses:

1. definition=the tangible substance that goes into the makeup of a physical object | examples=coal is a hard black material
- This refers to physical substance. Genetic material (DNA/RNA) is a tangible substance (though microscopic) that makes up the physical genetic component of cells. This seems plausible.

2. definition=information (data or ideas or observations) that can be used or reworked into a finished form | examples=the archives provided rich material for a definitive biography
- This is about information/data for creative or intellectual work. "Genetic material" is not being used in this sense. While DNA contains information, the phrase "genetic material" specifically refers to the physical substance carrying genetic information, not information as abstract data for a biography.

3. definition=artifact made by weaving or felting or knitting or crocheting natural or synthetic fibers | examples=the fabric in the curtains was light and semitransparent
- This is fabric/cloth. Not relevant.

4. definition=things needed for doing or making something | examples=writing materials
- This is supplies/tools. Not relevant.

5. definition=a person judged suitable for admission or employment | examples=he was university material
- Not relevant.

So sense 1 seems the best fit. "Genetic material" refers to the physical substance (DNA and RNA) that makes up the genetic component of cells. It is the tangible substance that goes into the makeup of a physical object (the cells, chromosomes, etc.).

Wait, let me reconsider. Is DNA/RNA considered a "tangible substance that goes into the makeup of a physical object"? In biological contexts, "genetic material" refers to the molecules (DNA, RNA) that carry genetic information. These are physical substances. Sense 1 is the general sense of physical matter/substance.

Sense 2 is about information/data/ideas. Could "genetic material" be interpreted as information? In modern biology, we often talk about genetic information. However, the specific phrase "genetic material" is a standard biological term referring to the physical molecules. The definition in sense 2 says "information (data or ideas or observations) that can be used or reworked into a finished form" with an example about archives for a biography. This is clearly about intellectual/creative material.

Therefore, sense 1 is correct.

Let me double-check by looking at how WordNet (which these definitions seem to come from) defines these senses.

WordNet senses for "material":
1. material, stuff - the tangible substance that goes into the makeup of a physical object
2. material - information (data or ideas or observations) that can be used or reworked into a finished form
3. fabric, cloth, material, textile - artifact made by weaving...
4. material - things needed for doing or making something
5. material - a person judged suitable for admission or employment

Yes, "genetic material" maps to sense 1. It's the physical stuff.

The answer should be just the number: 1.


[User]
Which numbered sense of "cell" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of <t>cells</t>).

Senses:
1. definition=any small compartment | examples=the cells of a honeycomb
2. definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. definition=a device that delivers an electric current as the result of a chemical reaction
4. definition=a small unit serving as part of or as the nucleus of a larger political movement
5. definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver
6. definition=small room in which a monk or nun lives
7. definition=a room where a prisoner is kept

reasoning_content:
We need to determine which sense of "cell" is used in the sentence: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of <t>cells</t>)."

The sentence is about biology, specifically about DNA, RNA, nucleotides, and genetic material of cells. So it's the biological sense: the basic structural and functional unit of all organisms. That's sense 2.

Let's double-check other senses:

1. any small compartment (like honeycomb) - not relevant.
2. (biology) the basic structural and functional unit of all organisms - yes.
3. electric cell - not relevant.
4. political cell - not relevant.
5. mobile phone cell - not relevant.
6. monk's cell - not relevant.
7. prison cell - not relevant.

Thus answer is 2.

The question: "Which numbered sense of 'cell' (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense."

Thus output: 2

We must ensure no extra text. Only the number.

Thus final answer: 2


[User]
Which numbered sense of "study" (marked with <t></t>) is used in the sentence below? Return only the number of the correct sense.

Sentence: How has Alimta been <t>studied</t>?

Senses:
1. definition=consider in detail and subject to an analysis in order to discover essential features or meaning | examples=analyze a sonnet by Shakespeare
2. definition=be a student; follow a course of study; be enrolled at an institute of learning
3. definition=give careful consideration to | examples=consider the possibility of moving
4. definition=be a student of a certain subject | examples=She is reading for the bar exam
5. definition=learn by reading books | examples=He is studying geology in his room
6. definition=think intently and at length, as for spiritual purposes | examples=He is meditating in his study

reasoning_content:
The user wants me to identify which numbered sense of "study" is used in the sentence "How has Alimta been <t>studied</t>?"

 Let me analyze the sentence:
 - "How has Alimta been studied?"
 - Alimta appears to be a medication (pemetrexed), used in chemotherapy
 - The question is asking about how it has been researched, analyzed, or investigated scientifically

 Now let's look at the senses:

 1. "consider in detail and subject to an analysis in order to discover essential features or meaning" | examples=analyze a sonnet by Shakespeare
    - This fits scientific research and analysis of a drug
    - To study a drug means to analyze it, test it, research it

 2. "be a student; follow a course of study; be enrolled at an institute of learning"
    - This is about being a student, not applicable to a drug being studied

 3. "give careful consideration to" | examples=consider the possibility of moving
    - This is about considering something, but less about systematic analysis/research
    - "How has Alimta been given careful consideration?" doesn't quite fit as well as sense 1

 4. "be a student of a certain subject" | examples=She is reading for the bar exam
    - Again about being a student, not applicable to a drug

 5. "learn by reading books" | examples=He is studying geology in his room
    - This is about learning from books, not about scientific research on a drug

 6. "think intently and at length, as for spiritual purposes" | examples=He is meditating in his study
    - This is meditation/contemplation, not applicable

 Sense 1 is the best fit because "studied" in the context of a drug (Alimta) means it has been subjected to scientific analysis, research, and investigation to discover its features, effects, and meaning (in terms of medical efficacy).

 The phrase "How has X been studied?" typically asks about the methodology of research and analysis applied to X. This aligns with sense 1: considering in detail and subjecting to analysis.

 So the answer should be 1.