[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cells
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 The user wants me to perform Word Sense Disambiguation on the word "cells" in the given context. The target lemma is "cell" and the surface form is "cells".

Let me analyze the context:
- The text is about Alimta (pemetrexed), a cytotoxic medicine
- It says: "a medicine that kills <t>cells</t> that are dividing, such as cancer cells"
- It mentions "nucleotides (the building blocks of DNA and RNA, the genetic material of cells)"

So the context is clearly biological/medical. It's talking about:
- Cancer cells
- Cells dividing
- DNA and RNA of cells
- Biological organisms

Now let's look at the candidate senses:

1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
   - This is about physical compartments like honeycomb cells. Not biological cells.

2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
   - This is the biological definition of a cell. This matches the context perfectly: cancer cells, cells dividing, genetic material of cells.

3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
   - This is about batteries/electric cells. Not relevant here.

4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
   - Political cell. Not relevant.

5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
   - Cell phone. Not relevant.

6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
   - Monastic cell. Not relevant.

7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell
   - Prison cell. Not relevant.

The context clearly discusses biological cells - specifically cancer cells and cells dividing. The text mentions DNA, RNA, nucleotides, and antimetabolites in the context of killing dividing cells.

Therefore, sense index 2 (cell%1:03:00::) is the correct answer.

Wait, I need to check the indexing. The user lists them as:
1. sense_key=cell%1:06:03::
2. sense_key=cell%1:03:00::
3. sense_key=cell%1:06:00::
4. sense_key=cell%1:14:00::
5. sense_key=cell%1:06:04::
6. sense_key=cell%1:06:02::
7. sense_key=cell%1:06:01::

So the biological sense is index 2.

The output should be: {"sense_index": 2}

Let me double-check:
- "kills cells that are dividing, such as cancer cells" - definitely biological cells
- "genetic material of cells" - definitely biological
- This is the standard biological definition of cell.

Yes, sense 2 is correct.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: divide
Target surface form: dividing
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=divide%2:41:00:: | definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire after World War I
2. sense_key=divide%2:31:00:: | definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven?
3. sense_key=divide%2:42:00:: | definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries
4. sense_key=divide%2:35:00:: | definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated
5. sense_key=divide%2:38:00:: | definition=make a division or separation | synonyms=separate
6. sense_key=divide%2:35:01:: | definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

finish_reason: stop

role: assistant

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the word "dividing" in the given context.

Let me analyze the context:
- The text is about a medicine called Alimta (pemetrexed)
- It's described as a "cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells)"
- The explanation continues: "pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides"

So "dividing" here refers to cells that are undergoing cell division (mitosis) - cells that are splitting into two daughter cells, reproducing, or multiplying.

Now let's look at the candidate senses:

1. sense_key=divide%2:41:00:: | definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire after World War I
- This is about separating something into parts. While cell division involves separating, this sense seems more about physical division of objects or territories, not biological cell division.

2. sense_key=divide%2:31:00:: | definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven?
- This is mathematical division. Not relevant here.

3. sense_key=divide%2:42:00:: | definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries
- This is about creating a separation/barrier between two things. Not relevant for cells dividing.

4. sense_key=divide%2:35:00:: | definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated
- This is about things coming apart or separating. This could potentially apply to cell division as cells "come apart" into two.

5. sense_key=divide%2:38:00:: | definition=make a division or separation | synonyms=separate
- This is vague. Could apply to cell division.

6. sense_key=divide%2:35:01:: | definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea
- This involves an external agent forcing things apart. Not quite right for cell division which is an active biological process.

Wait, I need to look more carefully at the WordNet senses. Let me think about what "dividing" means in the context of cells.

In biology, when we say cells are "dividing", we mean they are undergoing the process of cell division - where one cell splits into two. This is an intransitive use (cells divide).

Looking at the definitions:
- Sense 1: "separate into parts or portions" - This is typically transitive (divide X into Y)
- Sense 4: "come apart" - This is intransitive (X divides/comes apart)
- Sense 6: "force, take, or pull apart" - This is transitive with an agent

But actually, looking at the examples:
- Sense 1 examples: "divide the cake" (transitive), "carved up" (transitive)
- Sense 4: "The two pieces that we had glued separated" - this is about things coming apart

However, I should check if there's a specific sense for biological division.

Actually, looking at the context: "cells that are dividing" - this is describing cells that are in the process of cell division.

Sense 1: "separate into parts or portions" - This could work for cells dividing (separating into parts), but it's usually used transitively.

Sense 4: "come apart" - This is intransitive. "The two pieces... separated"

Sense 5: "make a division or separation" - This could be transitive or intransitive?

Let me reconsider the WordNet senses more carefully. The sense keys give clues:
- divide%2:41:00:: - verb.social (41)
- divide%2:31:00:: - verb.cognition (31)
- divide%2:42:00:: - verb.contact (42)
- divide%2:35:00:: - verb.change (35)
- divide%2:38:00:: - verb.contact (38)
- divide%2:35:01:: - verb.change (35)

Wait, the numbers after %2: indicate the lexicographer file (semantic category):
- 31 = verb.cognition (mathematical)
- 35 = verb.change (change of state)
- 38 = verb.contact
- 41 = verb.social
- 42 = verb.contact

For cell division, this is a biological process where a cell changes state by splitting into two. This would likely be in verb.change.

Sense 4: divide%2:35:00:: | definition=come apart | synonyms=separate, part
Sense 6: divide%2:35:01:: | definition=force, take, or pull apart | synonyms=separate, disunite, part

Sense 4 seems to fit best for cell division - cells "come apart" or separate into two daughter cells. This is an intransitive use.

But wait, I should check if sense 1 could be used intransitively. "The cells divide" - could this be sense 1? "separate into parts or portions"

Actually, looking at standard WordNet usage for biological contexts:
- "cells divide" is typically sense 1? Or sense 4?

Let me think about the difference:
- Sense 1: divide = separate into parts (transitive or intransitive?)
- Sense 4: divide = come apart (intransitive)

In biology, "cells divide" is intransitive - the cells are the ones doing the dividing (the subject), and they split into parts.

But sense 1 examples show transitive usage: "divide the cake", "carved up the Ottoman Empire".

Sense 4 example: "The two pieces that we had glued separated" - here "separated" is used intransitively.

Sense 6: "He separated the fighting children" - transitive with agent.

Sense 5: "make a division or separation" - could be either?

Actually, looking at the context again: "cells that are dividing"

In biological terminology, cell division is the process by which a parent cell divides into two or more daughter cells. This is an intransitive process (the cell divides).

Between sense 1 and sense 4:
- Sense 1 focuses on the action of separating something into parts
- Sense 4 focuses on the state of coming apart

But I think for "cells dividing", sense 1 is actually the correct WordNet sense. Let me verify.

Actually, looking at WordNet online or standard usage:
- divide.v.01: "separate into parts or portions" - usually transitive
- divide.v.02: "perform a division" - mathematical
- divide.v.03: "act as a barrier between" - separate spatially
- divide.v.04: "come apart" - "The two pieces that we had glued separated"
- divide.v.05: "make a division or separation"
- divide.v.06: "force, take, or pull apart"

For cells, when we say "cells are dividing", we mean they are separating into parts (daughter cells). This aligns with sense 1 conceptually, even if the examples given are transitive. WordNet senses often cover both transitive and intransitive uses.

But wait, sense 4 "come apart" might be better for intransitive biological division.

Let me reconsider the glosses carefully:

Sense 1: "separate into parts or portions"
- This captures the essence of cell division: a cell separates into parts (daughter cells).

Sense 4: "come apart"
- This suggests breaking apart, disintegrating, or separating from a joined state. While cells do separate, "come apart" suggests something falling apart rather than the organized process of cell division.

Sense 6: "force, take, or pull apart" - requires an external agent.

Sense 5: "make a division or separation" - this is vague.

Sense 3: barrier between - no.

Sense 2: mathematical - no.

So it's between 1 and 4.

Given that:
1. The context is about cancer cells dividing/multiplying
2. This is the standard biological process of cell division
3. Sense 1 "separate into parts or portions" best captures the meaning of one cell becoming two cells (splitting into portions)
4. Even though the examples for sense 1 are transitive, this sense is used for intransitive biological division in WordNet

I believe sense 1 is the correct answer.

But let me double-check. Is there any chance sense 4 is correct?

Sense 4 synonyms: separate, part
Example: "The two pieces that we had glued separated"

This suggests a separation of things that were joined. In cell division, the cell wasn't previously "apart" - it's one unit that becomes two. So "come apart" might suggest falling to pieces or detaching, which isn't quite right.

Sense 1: "separate into parts" - this is exactly what cell division is.

Also, looking at the synonym "split" in sense 1 - we often say cells "split" or "divide" in biology.

Therefore, sense 1 (divide%2:41:00::) is the best choice.

Wait, I should check if there's a specific sense for biological reproduction. Looking at the candidate list provided, there isn't one specifically labeled as such. So it must be one of these general senses.

Between sense 1 (separate into parts) and sense 4 (come apart), sense 1 is definitely the better fit for cell division.

Final check: The context mentions "cells that are dividing, such as cancer cells". Cancer cells are characterized by uncontrolled division/multiplication. This is the process of splitting into daughter cells.

Answer: sense_index: 1

format: unknown

native_finish_reason: stop

provider: Moonshot AI

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: body
Target surface form: body
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=body%1:08:00:: | definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
2. sense_key=body%1:14:00:: | definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium; the student body
3. sense_key=body%1:08:02:: | definition=a natural object consisting of a dead animal or person | synonyms=dead body | examples=they found the body in the lake
4. sense_key=body%1:17:00:: | definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. sense_key=body%1:08:01:: | definition=the body excluding the head and neck and limbs | synonyms=torso, trunk | examples=they moved their arms and legs and bodies
6. sense_key=body%1:14:02:: | definition=a collection of particulars considered as a system | examples=a body of law; a body of doctrine
7. sense_key=body%1:07:00:: | definition=the property of holding together and retaining its shape | synonyms=consistency, consistence, eubstance | examples=wool has more body than rayon; when the dough has enough consistency it is ready to bake
8. sense_key=body%1:10:00:: | definition=the central message of a communication | examples=the body of the message was short
9. sense_key=body%1:07:01:: | definition=the main mass of a thing
10. sense_key=body%1:06:01:: | definition=a resonating chamber in a musical instrument (as the body of a violin) | synonyms=soundbox
11. sense_key=body%1:06:00:: | definition=the external structure of a vehicle | examples=the body of the car was badly rusted

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 The user wants me to perform Word Sense Disambiguation for the word "body" in the given context.

 Context analysis:
 The text is about a medicine called Alimta (pemetrexed). The specific sentence is: "In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides..."

 This is referring to the human body - the entire physical structure of a human being where the drug is metabolized.

 Looking at the candidate senses:
 1. sense_key=body%1:08:00:: | definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
 2. sense_key=body%1:14:00:: | definition=a group of persons...
 3. sense_key=body%1:08:02:: | definition=a natural object consisting of a dead animal or person...
 4. sense_key=body%1:17:00:: | definition=an individual 3-dimensional object...
 5. sense_key=body%1:08:01:: | definition=the body excluding the head and neck and limbs (torso)...
 6. sense_key=body%1:14:02:: | definition=a collection of particulars...
 7. sense_key=body%1:07:00:: | definition=the property of holding together...
 8. sense_key=body%1:10:00:: | definition=the central message...
 9. sense_key=body%1:07:01:: | definition=the main mass of a thing
 10. sense_key=body%1:06:01:: | definition=a resonating chamber...
 11. sense_key=body%1:06:00:: | definition=the external structure of a vehicle...

 The context clearly refers to the human body as an organism where the drug is processed. This matches sense 1: "the entire structure of an organism (an animal, plant, or human being)".

 Sense 5 refers to the torso (excluding head, neck, limbs), which is too specific and not what is meant here (the drug works throughout the entire organism).

 Sense 3 refers to a dead body, which is not the case here.

 Therefore, the correct sense is index 1.

 Wait, I need to check the indexing. The user lists them as:
 1. sense_key=body%1:08:00::
 2. sense_key=body%1:14:00::
 ...

 So I should return {"sense_index": 1}.

 Let me double-check:
 - The context is about a drug being converted in the "body" - this is clearly the biological/organism sense.
 - Sense 1 matches: "the entire structure of an organism (an animal, plant, or human being)"
 - The example "he felt as if his whole body were on fire" also supports this being the living organism.

 Yes, sense 1 is correct.

provider: Chutes


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: convert
Target surface form: converted
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=convert%2:30:00:: | definition=change from one system to another or to a new plan or policy | synonyms=change over | examples=We converted from 220 to 110 Volt
2. sense_key=convert%2:30:03:: | definition=change the nature, purpose, or function of something | examples=convert lead into gold; convert hotels into jails
3. sense_key=convert%2:30:01:: | definition=change religious beliefs, or adopt a religious belief | examples=She converted to Buddhism
4. sense_key=convert%2:30:02:: | definition=exchange or replace with another, usually of the same kind or category | synonyms=change, exchange, commute | examples=Could you convert my dollars into pounds?; He changed his name
5. sense_key=convert%2:30:07:: | definition=cause to adopt a new or different faith | examples=The missionaries converted the Indian population
6. sense_key=convert%2:33:02:: | definition=score an extra point or points after touchdown by kicking the ball through the uprights or advancing the ball into the end zone | examples=Smith converted and his team won
7. sense_key=convert%2:33:01:: | definition=complete successfully | examples=score a penalty shot or free throw
8. sense_key=convert%2:33:00:: | definition=score (a spare)
9. sense_key=convert%2:32:00:: | definition=make (someone) agree, understand, or realize the truth or validity of something | synonyms=win over, convince | examples=He had finally convinced several customers of the advantages of his product
10. sense_key=convert%2:30:09:: | definition=exchange a penalty for a less severe one | synonyms=commute, exchange
11. sense_key=convert%2:30:04:: | definition=change in nature, purpose, or function; undergo a chemical change | examples=The substance converts to an acid

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 The user wants me to perform Word Sense Disambiguation on the word "converted" in the given context.

 Let me analyze the context:
 "In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes..."

 The sentence is describing a chemical/biological process where pemetrexed (a medicine) is changed into an active form inside the body. This is a biochemical transformation.

 Now let's look at the candidate senses:

 1. convert%2:30:00:: - change from one system to another or to a new plan or policy (e.g., converting voltage systems) - Not quite right, this is about systems/policies.

 2. convert%2:30:03:: - change the nature, purpose, or function of something (e.g., convert lead into gold, convert hotels into jails) - This is close, but seems more about physical transformation of objects or purposes.

 3. convert%2:30:01:: - change religious beliefs - Not relevant.

 4. convert%2:30:02:: - exchange or replace with another, usually of the same kind or category (e.g., currency exchange) - Not quite right.

 5. convert%2:30:07:: - cause to adopt a new faith - Not relevant.

 6. convert%2:33:02:: - score points in football/rugby - Not relevant.

 7. convert%2:33:01:: - complete successfully (sports) - Not relevant.

 8. convert%2:33:00:: - score a spare (bowling) - Not relevant.

 9. convert%2:32:00:: - convince someone - Not relevant.

 10. convert%2:30:09:: - exchange a penalty for a less severe one - Not relevant.

 11. convert%2:30:04:: - change in nature, purpose, or function; undergo a chemical change (e.g., The substance converts to an acid) - This seems perfect! The example mentions a substance converting to an acid, which is a chemical change. In our context, pemetrexed is converted into an active form - this is a chemical/biochemical transformation.

 Let me double-check sense 2 vs sense 11:
 - Sense 2: "change the nature, purpose, or function of something" - examples: "convert lead into gold; convert hotels into jails"
 - Sense 11: "change in nature, purpose, or function; undergo a chemical change" - examples: "The substance converts to an acid"

 The key here is that sense 11 specifically mentions "undergo a chemical change" and the example is about a substance converting chemically. The context describes a drug (pemetrexed) being chemically transformed into an active form in the body. This is clearly a chemical/biochemical conversion.

 Therefore, sense 11 (index 11) is the best match.

 Wait, I need to check the indexing. The user lists:
 1. sense_key=...
 2. sense_key=...
 ...
 11. sense_key=convert%2:30:04::

 So the index would be 11.

 Let me verify the sense_key for sense 11: convert%2:30:04::
 The definition is: "change in nature, purpose, or function; undergo a chemical change"
 Example: "The substance converts to an acid"

 This matches perfectly with the biochemical conversion of pemetrexed into its active form.

 Sense 2 (convert%2:30:03::) is "change the nature, purpose, or function of something" - this is more general and the examples suggest transformation of objects (lead to gold, hotels to jails) rather than chemical/biological processes.

 Sense 11 is specifically about chemical change, which is exactly what happens when a prodrug or inactive compound is metabolized into an active form in the body.

 Therefore, the answer is sense_index: 11.

provider: DigitalOcean


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
7. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
13. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 The user wants me to perform Word Sense Disambiguation for the word "active" in the given context.

 Context analysis:
 The sentence is: "In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides..."

 The word "active" here describes a "form" of the drug pemetrexed. It means the form that is biologically active, effective, or capable of producing an effect (blocking enzymes).

 Looking at the candidate senses:

 1. active%3:00:02:: - tending to become more severe or wider in scope (e.g., active tuberculosis) - This doesn't fit. The drug form isn't becoming more severe.

 2. active%5:00:00:operational:00 - engaged in military/naval operations - Not relevant.

 3. active%3:00:03:: - disposed to take action or effectuate change - This is about a person's disposition, not a chemical form.

 4. active%5:00:00:involved:00 - taking part in an activity - This is about participation, not suitable for a chemical compound.

 5. active%3:00:01:: - characterized by energetic activity - This describes physical energy/movement, not suitable for a molecular form.

 6. active%3:00:07:: - exerting influence or producing a change or effect - examples: "an active ingredient" - This fits perfectly! The "active form" of a drug is the form that exerts influence or produces a change/effect (blocking enzymes).

 7. active%3:00:06:: - full of activity or engaged in continuous activity - describes busy places/markets, not suitable.

 8. active%5:00:00:existent:00 - in operation - "alive" - Could be close, but sense 6 (3:00:07) is more specific about producing effects.

 9. active%3:00:10:: - sun-related - not relevant.

 10. active%3:00:09:: - grammatical voice - not relevant.

 11. active%3:00:00:: - verbs expressing action - not relevant (this is an adjective modifying "form").

 12. active%3:00:05:: - volcanos capable of erupting - not relevant.

 13. active%3:00:04:: - volcanos erupting - not relevant.

 14. active%3:00:08:: - engaged in full-time work - not relevant.

 The best fit is sense 6: active%3:00:07:: with definition "exerting influence or producing a change or effect" and example "an active ingredient". In pharmacology, the "active form" of a drug is the form that has biological activity - i.e., it produces the therapeutic effect.

 Wait, let me check the indexing. The user lists them as:
 1. sense_key=active%3:00:02::
 2. sense_key=active%5:00:00:operational:00
 3. sense_key=active%3:00:03::
 4. sense_key=active%5:00:00:involved:00
 5. sense_key=active%3:00:01::
 6. sense_key=active%3:00:07::
 7. sense_key=active%3:00:06::
 8. sense_key=active%5:00:00:existent:00
 9. sense_key=active%3:00:10::
 10. sense_key=active%3:00:09::
 11. sense_key=active%3:00:00::
 12. sense_key=active%3:00:05::
 13. sense_key=active%3:00:04::
 14. sense_key=active%3:00:08::

 So sense 6 is the one with key active%3:00:07::.

 The context describes a drug being converted into a form that "blocks the activity of enzymes" - this is definitely "exerting influence or producing a change or effect".

 Therefore, the answer should be {"sense_index": 6}.

provider: Phala


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: form
Target surface form: form
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=form%1:10:00:: | definition=the phonological or orthographic sound or appearance of a word that can be used to describe or identify something | synonyms=word form, signifier, descriptor | examples=the inflected forms of a word can be represented by a stem and a list of inflections to be attached
2. sense_key=form%1:09:01:: | definition=a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety | examples=sculpture is a form of art; what kinds of desserts are there?
3. sense_key=form%1:09:00:: | definition=a perceptual structure | synonyms=shape, pattern | examples=the composition presents problems for students of musical form; a visual pattern must include not only objects but the spaces between them
4. sense_key=form%1:07:01:: | definition=any spatial attributes (especially as defined by outline) | synonyms=shape, configuration, contour, conformation | examples=he could barely make out their shapes
5. sense_key=form%1:08:00:: | definition=alternative names for the body of a human being | synonyms=human body, physical body, material body, soma, build, figure | examples=Leonardo studied the human body; he has a strong physique
6. sense_key=form%1:03:00:: | definition=the spatial arrangement of something as distinct from its substance | synonyms=shape | examples=geometry is the mathematical science of shape
7. sense_key=form%1:07:00:: | definition=the visual appearance of something or someone | synonyms=shape, cast | examples=the delicate cast of his features
8. sense_key=form%1:10:01:: | definition=a printed document with spaces in which to write | examples=he filled out his tax form
9. sense_key=form%1:14:02:: | definition=(biology) a group of organisms within a species that differ in trivial ways from similar groups | synonyms=variant, strain, var. | examples=a new strain of microorganisms
10. sense_key=form%1:10:02:: | definition=an arrangement of the elements in a composition or discourse | examples=the essay was in the form of a dialogue; he first sketches the plot in outline form
11. sense_key=form%1:07:03:: | definition=a particular mode in which something is manifested | examples=his resentment took the form of extreme hostility
12. sense_key=form%1:26:00:: | definition=(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary | synonyms=phase | examples=the reaction occurs in the liquid phase of the system
13. sense_key=form%1:14:00:: | definition=a body of students who are taught together | synonyms=class, grade, course | examples=early morning classes are always sleepy
14. sense_key=form%1:07:02:: | definition=an ability to perform well | examples=he was at the top of his form; the team was off form last night
15. sense_key=form%1:06:00:: | definition=a life-size dummy used to display clothes | synonyms=mannequin, manikin, mannikin, manakin
16. sense_key=form%1:06:01:: | definition=a mold for setting concrete | examples=they built elaborate forms for pouring the foundation

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 The user wants me to perform Word Sense Disambiguation for the word "form" in the given context.

Context analysis:
The sentence is: "In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes..."

This is talking about a drug (pemetrexed) being converted into an active "form" in the body. This refers to a chemical or biological state of the substance.

Looking at the candidate senses:

1. form%1:10:00:: - phonological or orthographic appearance of a word. Not relevant here (not about linguistics).

2. form%1:09:01:: - a category of things distinguished by common characteristic. Could potentially fit, but "active form" usually refers to a chemical state.

3. form%1:09:00:: - perceptual structure. Not quite right.

4. form%1:07:01:: - spatial attributes. Not relevant.

5. form%1:08:00:: - human body. Not relevant.

6. form%1:03:00:: - spatial arrangement. Not quite.

7. form%1:07:00:: - visual appearance. Not relevant.

8. form%1:10:01:: - printed document. Not relevant.

9. form%1:14:02:: - biology group of organisms within a species. This is about biological classification (strain, variant), but here we're talking about a chemical compound being converted to an active form.

10. form%1:10:02:: - arrangement of elements in composition. Not relevant.

11. form%1:07:03:: - particular mode in which something is manifested. This could work - "his resentment took the form of extreme hostility" - similar to "converted into an active form".

12. form%1:26:00:: - (physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state... This seems very relevant. Pemetrexed being converted into an active form refers to its chemical state. The definition mentions "physical chemistry" and "distinct state of matter".

13. form%1:14:00:: - body of students. Not relevant.

14. form%1:07:02:: - ability to perform well. Not relevant.

15. form%1:06:00:: - mannequin. Not relevant.

16. form%1:06:01:: - mold for concrete. Not relevant.

Between sense 11 and 12:
Sense 11: "a particular mode in which something is manifested" - examples: "his resentment took the form of extreme hostility"
Sense 12: "(physical chemistry) a distinct state of matter in a system..."

The context is clearly about chemistry/biology - a drug being converted into an active chemical form. This is a chemical state. Sense 12 specifically mentions physical chemistry and state of matter.

However, let me look at sense 9 again: "(biology) a group of organisms within a species that differ in trivial ways from similar groups" - this is about strains/variants of organisms, not chemical forms of drugs.

Sense 12 is the best fit: "distinct state of matter in a system" - the active form of pemetrexed refers to its chemical state after conversion in the body.

Wait, let me reconsider sense 11: "a particular mode in which something is manifested". In biochemistry, when we say "active form", we could mean the mode in which the drug is manifested (active vs inactive). But sense 12 is more specific to physical chemistry.

Actually, looking at the WordNet hierarchy:
- form%1:26:00:: is under noun.state (state of matter)
- form%1:07:03:: is under noun.attribute

The phrase "converted into an active form" in a chemical/pharmaceutical context strongly suggests a chemical state or phase. The drug is converted from one chemical state (inactive) to another (active).

Sense 12 definition: "(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary"

Wait, actually, in the context of enzymes and prodrugs, "active form" usually means the metabolite or the chemical species that is biologically active. This might not be a "state of matter" in the phase sense (solid/liquid/gas), but rather a chemical form (like an isomer, or a metabolite).

But looking at the available senses, sense 12 is the closest to a chemical/physical state. However, let me check if there's a better fit.

Sense 2: "a category of things distinguished by some common characteristic or quality" - "an active form" could be a kind/type of the substance.

But in pharmaceutical contexts, "active form" typically refers to the specific chemical state or modification of the molecule.

Actually, looking at WordNet examples for sense 12: "the reaction occurs in the liquid phase of the system" - this is about phases (solid, liquid, gas).

But "active form" of a drug is not necessarily about phase. It's about the chemical structure or state.

Let me reconsider sense 11: "a particular mode in which something is manifested" - example: "his resentment took the form of extreme hostility". This is about manifestation.

In the sentence: "pemetrexed is converted into an active form" - this means it changes into an active manifestation/state.

But actually, looking at standard WSD for "form" in biochemical contexts, sense 12 (physical chemistry) is often used for chemical forms, or sense 2 (kind/sort).

Wait, I should look at the synonyms for sense 12: "phase". Is "active phase" the same as "active form"? Not exactly.

Let me look at sense 9 again: "(biology) a group of organisms within a species..." - no.

What about sense 1: "word form" - no.

Actually, looking carefully at the context: "pemetrexed is converted into an active form that blocks..."

In biochemistry, this could be referring to:
- A metabolic conversion (prodrug to active drug)
- A conformational change

But given the options, sense 11 "a particular mode in which something is manifested" seems plausible, but sense 12 "distinct state of matter" also seems plausible.

However, looking at the WordNet sense 12, it's specifically about physical states (solid, liquid, gas, plasma) and phases. A chemical compound being converted to its "active form" is not typically described as changing its state of matter phase (like from solid to liquid), but rather its chemical structure.

But wait, is there a sense about chemical forms? Let me check the list again.

Sense 2: kind, sort, variety - "sculpture is a form of art"
Sense 3: perceptual structure
Sense 4: spatial attributes
Sense 6: spatial arrangement
Sense 7: visual appearance

None of these specifically mention chemical structure.

But sense 11: "a particular mode in which something is manifested" - this is general enough to cover "active form" meaning the active manifestation of the drug.

However, looking at the example for sense 11: "his resentment took the form of extreme hostility" - this is about abstract things taking a form.

The drug taking an active form is somewhat similar - it takes on an active mode/manifestation.

But I recall that in WordNet, for chemical compounds, "form" often maps to sense 12 (state of matter) or sense 2 (kind).

Actually, looking at the definition of sense 12 again: "distinct state of matter in a system; matter that is identical in chemical composition and physical state..."

If pemetrexed is converted into an active form, it might be chemically modified (e.g., phosphorylated, or metabolized), so it's not identical in chemical composition to the original. So sense 12 might not fit perfectly because it says "identical in chemical composition".

Sense 2: "a category of things distinguished by some common characteristic or quality" - an active form is a category/type of the substance.

But "form" in "active form" in pharmacology usually refers to the specific chemical species.

Let me reconsider sense 9: "(biology) a group of organisms within a species..." - no, that's for organisms.

What about sense 1:10:00 - word form? No.

Actually, looking at the sentence structure: "converted into an active form"

This is similar to "water in the form of ice" or "energy in the form of heat".

For "water in the form of ice", which sense would apply?
- Sense 12 (state of matter)? Ice is a state of matter.
- Sense 11 (mode of manifestation)? Yes, ice is a form (mode) of water.

But for a drug being converted to an active form, it's becoming a different chemical entity (metabolite), not just changing phase.

However, looking at the available options, sense 11 seems the most general and applicable: "a particular mode in which something is manifested".

But let me check if there's a pattern in WordNet for "active form".

Actually, looking at sense 12's synonyms: "phase". The example is about liquid phase. This is clearly about states of matter.

In the context: "pemetrexed is converted into an active form" - this is likely referring to the active metabolite or the active chemical species. This is not a "phase" in the physical chemistry sense.

Sense 2: "kind, sort, variety" - "sculpture is a form of art". This is about categorization.

"An active form" could mean a type/kind of pemetrexed.

But I think the best fit is actually sense 11: "a particular mode in which something is manifested".

Wait, I should look at sense 1:07:03:: carefully. The definition is "a particular mode in which something is manifested". The example is "his resentment took the form of extreme hostility".

In our case, the drug takes the form of [an active version].

But actually, looking at biomedical texts, "active form" often refers to the chemically active state of a molecule.

Given the choices, and that this is a pharmaceutical text about a cytotoxic medicine, the most appropriate sense is likely sense 12 (physical chemistry state) if we interpret "form" as chemical state, or sense 2 if we interpret it as type/kind.

But sense 12 specifically mentions "physical chemistry" which matches the context of enzymes and chemical reactions.

Even though "active form" might not be a phase change (solid to liquid), in WordNet's hierarchy, chemical forms might be categorized under state of matter.

However, I think sense 11 is safer because it doesn't specify "identical chemical composition" like sense 12 does. When pemetrexed is converted to its active form, it likely undergoes a chemical change (metabolism), so it's not identical in composition.

Therefore, sense 11: "a particular mode in which something is manifested" is better.

But wait, looking at the index numbers:
- sense_key=form%1:07:03:: is index 11
- sense_key=form%1:26:00:: is index 12

Let me double-check the context: "pemetrexed is converted into an active form that blocks the activity of enzymes"

This is describing the mechanism of action. Pemetrexed is a prodrug or is metabolized to an active metabolite.

In many WSD datasets, "form" in "active form" for drugs is often tagged as sense 2 (kind, sort) or sense 11 (mode).

But looking at the specific WordNet senses provided, sense 11 seems most appropriate for "manifestation".

However, I recall that in WordNet 3.0 or 3.1, there might be a specific sense for chemical forms, but looking at the list provided, sense 12 is the only one close to chemistry.

Let me reconsider sense 9: "(biology) a group of organisms within a species..." - this is variant/strain. Not for chemicals.

Actually, looking at the definition of sense 2 again: "a category of things distinguished by some common characteristic or quality". If we consider "active form" as a category of pemetrexed (the active category vs inactive), this could work.

But "converted into" suggests transformation into a specific manifestation.

I think I should go with sense 11 (index 11).

Wait, looking at the example for sense 11: "his resentment took the form of extreme hostility"
And the definition: "a particular mode in which something is manifested"

For the drug: "pemetrexed is converted into an active form" - it is manifested in an active mode.

Yes, this fits.

But let me check if sense 12 could fit. If "form" means "phase" or "state", then "active state" could work. But the definition requires "identical in chemical composition", which is violated if it's converted (metabolized).

Therefore, sense 11 is the best choice.

Actually, looking at the list once more, is there any other sense?
Sense 1:10:00 - word form
Sense 1:09:01 - kind/sort/variety (index 2)
Sense 1:09:00 - perceptual structure (index 3)
Sense 1:07:01 - spatial attributes (index 4)
Sense 1:08:00 - human body (index 5)
Sense 1:03:00 - spatial arrangement (index 6)
Sense 1:07:00 - visual appearance (index 7)
Sense 1:10:01 - printed document (index 8)
Sense 1:14:02 - biology group (index 9)
Sense 1:10:02 - arrangement in composition (index 10)
Sense 1:07:03 - particular mode manifested (index 11)
Sense 1:26:00 - physical chemistry state (index 12)
Sense 1:14:00 - students (index 13)
Sense 1:07:02 - ability to perform (index 14)
Sense 1:06:00 - mannequin (index 15)
Sense 1:06:01 - mold (index 16)

Given that the context is about a chemical conversion, and sense 12 is the only one mentioning physical chemistry, and despite the "identical chemical composition" issue, it might be the intended sense for "chemical form".

But I think the "identical chemical composition" is a strong constraint that makes sense 12 wrong for a metabolite conversion.

Between sense 2 (kind/variety) and sense 11 (mode of manifestation):
- "An active form" as a kind of pemetrexed: possible
- "An active form" as a mode of manifestation: possible

But "converted into" strongly suggests a change of state/manifestation, not just categorization.

Also, looking at the phrase "active form" in medical dictionaries, it refers to the form in which a drug is active (manifested as active).

I will go with index 11.

Wait, I should verify if there's any other interpretation.

Could it be sense 1 (word form)? No.
Could it be sense 3 (musical form)? No.

I think 11 is correct.

But let me reconsider sense 12 one more time. In physical chemistry, "form" can refer to polymorphs or allotropes? No, those are different forms but same composition. But if it's metabolized, composition changes.

Unless... pemetrexed is converted into an active form meaning it changes conformation or state (like from inactive conformation to active conformation) without changing chemical composition? Some drugs are activated by pH changes or binding, not metabolism. But the text says "converted into", which often implies metabolism.

However, looking at the Alimta (pemetrexed) mechanism, pemetrexed itself is the active form. It might not be a prodrug. Let me check my knowledge... Pemetrexed is a folate analog. It might be transported into cells and polyglutamated to become the active form (pemetrexed polyglutamate). This is a chemical modification (addition of glutamate residues), so composition changes.

Therefore, sense 12 is definitely wrong because composition changes.

So sense 11 is the answer.

Final check: sense 11 is "form%1:07:03::" with definition "a particular mode in which something is manifested".

Yes.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: block
Target surface form: blocks
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=block%2:35:00:: | definition=render unsuitable for passage | synonyms=barricade, blockade, stop, block off, block up, bar | examples=block the way; barricade the streets
2. sense_key=block%2:41:00:: | definition=hinder or prevent the progress or accomplishment of | synonyms=obstruct, blockade, hinder, stymie, stymy, embarrass | examples=His brother blocked him at every turn
3. sense_key=block%2:41:01:: | definition=stop from happening or developing | synonyms=stop, halt, kibosh | examples=Block his election; Halt the process
4. sense_key=block%2:32:00:: | definition=interfere with or prevent the reception of signals | synonyms=jam | examples=Jam the Voice of America; block the signals emitted by this station
5. sense_key=block%2:41:03:: | definition=run on a block system | examples=block trains
6. sense_key=block%2:39:05:: | definition=interrupt the normal function of by means of anesthesia | examples=block a nerve; block a muscle
7. sense_key=block%2:39:00:: | definition=shut out from view or get in the way so as to hide from sight | synonyms=obstruct | examples=The thick curtain blocked the action on the stage; The trees obstruct my view of the mountains
8. sense_key=block%2:35:03:: | definition=stamp or emboss a title or design on a book with a block | examples=block the book cover
9. sense_key=block%2:35:02:: | definition=obstruct | synonyms=stuff, lug, choke up | examples=My nose is all stuffed; Her arteries are blocked
10. sense_key=block%2:35:12:: | definition=block passage through | synonyms=obstruct, obturate, impede, occlude, jam, close up | examples=obstruct the path
11. sense_key=block%2:35:06:: | definition=support, secure, or raise with a block | examples=block a plate for printing; block the wheels of a car
12. sense_key=block%2:33:00:: | definition=impede the movement of (an opponent or a ball) | synonyms=parry, deflect | examples=block an attack
13. sense_key=block%2:31:00:: | definition=be unable to remember | synonyms=forget, blank out, draw a blank | examples=I'm drawing a blank; You are blocking the name of your first wife!
14. sense_key=block%2:30:01:: | definition=shape by using a block | examples=Block a hat; block a garment
15. sense_key=block%2:30:00:: | definition=shape into a block or blocks | examples=block the graphs so one can see the results clearly
16. sense_key=block%2:30:02:: | definition=prohibit the conversion or use of (assets) | synonyms=freeze, immobilize, immobilise | examples=Blocked funds; Freeze the assets of this hostile government

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the word "blocks" in the given context.

 Context analysis:
 - The text is about a medicine called Alimta (pemetrexed)
 - It describes how the medicine works: "pemetrexed is converted into an active form that blocks the activity of the enzymes"
 - The enzymes are involved in producing nucleotides (building blocks of DNA and RNA)
 - So the medicine prevents/interferes with the activity of these enzymes

 Looking at the candidate senses:

 1. block%2:35:00:: - render unsuitable for passage (physical blocking, like barricading)
 2. block%2:41:00:: - hinder or prevent the progress or accomplishment of (obstruct, hinder)
 3. block%2:41:01:: - stop from happening or developing (stop, halt)
 4. block%2:32:00:: - interfere with signals (jam signals)
 5. block%2:41:03:: - run on a block system (trains)
 6. block%2:39:05:: - interrupt by anesthesia (block a nerve)
 7. block%2:39:00:: - shut out from view (obstruct view)
 8. block%2:35:03:: - stamp/emboss with a block
 9. block%2:35:02:: - obstruct (stuff, lug, choke up) - physical obstruction like arteries
 10. block%2:35:12:: - block passage through (obstruct, obturate, impede, occlude)
 11. block%2:35:06:: - support with a block
 12. block%2:33:00:: - impede movement of opponent/ball (sports)
 13. block%2:31:00:: - be unable to remember
 14. block%2:30:01:: - shape by using a block
 15. block%2:30:00:: - shape into blocks
 16. block%2:30:02:: - prohibit conversion/use of assets (freeze)

 The context is about blocking enzyme activity. This is about inhibiting or preventing the function/activity of enzymes.

 Sense 2: "hinder or prevent the progress or accomplishment of" - synonyms include obstruct, hinder. This fits well with blocking enzyme activity (hindering their function).

 Sense 3: "stop from happening or developing" - this is also close, but "stop" might be too absolute. The medicine inhibits the enzymes, hindering their activity.

 Sense 9: "obstruct" with synonyms "stuff, lug, choke up" - examples mention arteries being blocked. This is physical obstruction.

 Sense 10: "block passage through" - also physical.

 Sense 2 seems most appropriate for abstract hindering/preventing of activity/processes. The enzymes' activity is being hindered/obstructed.

 Let me check the exact wording again: "blocks the activity of the enzymes"

 This is about inhibiting or obstructing the activity/function of something (enzymes).

 Sense 2: hinder or prevent the progress or accomplishment of
 Sense 3: stop from happening or developing

 Between 2 and 3, sense 2 seems better because:
 - It mentions "hinder or prevent" which covers inhibition
 - The examples include "His brother blocked him at every turn" which is about hindering progress
 - Enzyme inhibition is about hindering their function/activity

 However, looking at sense 9: "obstruct" with examples "Her arteries are blocked" - this is biological/physiological blocking.

 But sense 9 is specifically about physical obstruction (stuffing, choking up).

 Sense 2 is more general: "hinder or prevent the progress or accomplishment of"

 Actually, looking at WordNet structure, sense 2 (block%2:41:00::) is likely the sense used for blocking in the sense of obstructing or impeding an action or process.

 Sense 3 (block%2:41:01::) is more about stopping an event from happening (block his election).

 Blocking enzyme activity is about hindering the function/progress of the enzymes in their task of producing nucleotides.

 So sense 2 seems best.

 Wait, let me reconsider sense 9 vs sense 2.

 Sense 9: block%2:35:02:: - obstruct, stuff, lug, choke up. Examples: "My nose is all stuffed; Her arteries are blocked"
 This is physical blockage.

 Sense 2: block%2:41:00:: - hinder or prevent the progress or accomplishment of. Examples: "His brother blocked him at every turn"
 This is abstract hindrance.

 In biochemistry, when we say a drug "blocks" an enzyme, we usually mean it inhibits it - which is closer to hindering/preventing its function (sense 2) rather than physically stuffing it (sense 9).

 Also, sense 10: block%2:35:12:: - block passage through, obstruct, obturate, impede, occlude, jam, close up. Examples: "obstruct the path"
 This is also physical.

 So for abstract "activity" of enzymes, sense 2 is the best fit.

 Actually, looking at the definition of sense 2 again: "hinder or prevent the progress or accomplishment of"
 And sense 3: "stop from happening or developing"

 In pharmacology, enzyme blockers inhibit enzymes, which prevents the reaction from happening. But "blocks the activity" specifically targets the function/operation.

 I think sense 2 is the correct choice.

 Let me double-check if there's a more specific sense for biological/chemical blocking...

 Sense 6: interrupt normal function by anesthesia (block a nerve) - this is close but specifically about anesthesia.

 Sense 4: interfere with signals (jam) - not signals.

 So yes, sense 2.

 Wait, I should check the WordNet sense keys to make sure I understand the numbering.

 The format is block%2:41:00::
 - 2 = verb
 - 41 = lexicographer file (probably verb.communication or verb.social? Actually 41 is likely verb.contact or similar)

 Actually, WordNet lexicographer file numbers:
 - 35 = verb.contact
 - 41 = verb.social? No, let me think.

 Standard WordNet lexicographer file numbers:
 - verb.contact = 35
 - verb.creation = 36
 - verb.body = 39
 - verb.change = 30
 - verb.cognition = 31
 - verb.communication = 32
 - verb.competition = 33
 - verb.consumption = 34
 - verb.contact = 35
 - verb.motion = 37
 - verb.perception = 38
 - verb.possession = 40
 - verb.social = 41
 - verb.stative = 42
 - verb.weather = 43

 So:
 - block%2:35:00:: = verb.contact
 - block%2:41:00:: = verb.social
 - block%2:41:01:: = verb.social (different sense)
 - block%2:32:00:: = verb.communication
 - block%2:39:05:: = verb.body
 - block%2:39:00:: = verb.body
 - block%2:35:03:: = verb.contact
 - block%2:35:02:: = verb.contact
 - block%2:35:12:: = verb.contact
 - block%2:35:06:: = verb.contact
 - block%2:33:00:: = verb.competition
 - block%2:31:00:: = verb.cognition
 - block%2:30:01:: = verb.change
 - block%2:30:00:: = verb.change
 - block%2:30:02:: = verb.change

 So sense 2 (block%2:41:00::) is in verb.social - "hinder or prevent the progress or accomplishment of"
 Sense 3 (block%2:41:01::) is also verb.social - "stop from happening or developing"

 In the context of enzymes, blocking their activity is a biological inhibition. In WordNet, this might be considered under verb.contact (physical blocking) or verb.social (abstract blocking).

 But "block an enzyme" is often considered a type of inhibition/hindrance.

 However, looking at sense 9 (block%2:35:02::) - "obstruct" with examples about arteries being blocked. This is verb.contact.

 But the definition mentions "stuff, lug, choke up" which implies physical filling.

 For enzymes, it's more about binding to the active site and preventing function - which is hindering.

 I think sense 2 is still the best choice.

 Actually, looking at the example for sense 2: "His brother blocked him at every turn" - this is about preventing someone from making progress.

 For enzymes, blocking their activity prevents them from accomplishing their function (producing nucleotides).

 So sense 2 fits well.

 Sense 3 "stop from happening or developing" - examples: "Block his election; Halt the process"
 This could also work, but "stop from happening" suggests preventing an event, whereas "blocks the activity" suggests ongoing hindrance of function.

 I'll go with sense 2.

 Wait, I need to be careful. The user wants the "sense_index" which appears to be the number in the list (1-16).

 So if I choose sense 2, I return {"sense_index": 2}.

 Let me reconsider if sense 9 might be better.
 Sense 9: "obstruct" - "My nose is all stuffed; Her arteries are blocked"
 This is biological context.

 But the synonyms "stuff, lug, choke up" suggest congestion, not enzymatic inhibition.

 Sense 2's synonyms: "obstruct, blockade, hinder, stymie, stymy, embarrass"
 These fit better with "hinder the activity".

 Also, in many WSD datasets, "block" in the context of blocking enzymes or receptors is tagged with the "hinder" sense (sense 2).

 Therefore, my final answer is sense_index 2.

provider: DeepInfra


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: involved
Target surface form: involved
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=involved%3:00:00:: | definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved; the problems involved
2. sense_key=involved%5:00:00:encumbered:00 | definition=entangled or hindered as if e.g. in mire | synonyms=mired | examples=the difficulties in which the question is involved; brilliant leadership mired in details and confusion
3. sense_key=involved%5:00:00:attached:01 | definition=emotionally involved
4. sense_key=involved%5:00:00:complex:00 | definition=highly complex or intricate and occasionally devious; ; ; ; ; ; ; ; - Sir Walter Scott | synonyms=Byzantine, convoluted, knotty, tangled, tortuous | examples=the Byzantine tax structure; Byzantine methods for holding on to his chairmanship
5. sense_key=involved%5:00:00:enclosed:00 | definition=enveloped | examples=a castle involved in mist; the difficulties in which the question is involved

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the word "involved" in the given context.

 Context analysis:
 - The text is about Alimta (pemetrexed), a cytotoxic medicine/antimetabolite used for cancer treatment.
 - The specific sentence: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."
 - Here, "involved" describes enzymes that participate in or are associated with the process of producing nucleotides.

 Candidate sense analysis:
 1. sense_key=involved%3:00:00:: | definition=connected by participation or association or use | examples="we accomplished nothing, simply because of the large number of people involved; the problems involved"
    - This fits perfectly. The enzymes are connected by participation/association with producing nucleotides. They participate in the process.

 2. sense_key=involved%5:00:00:encumbered:00 | definition=entangled or hindered as if e.g. in mire | synonyms=mired | examples="the difficulties in which the question is involved; brilliant leadership mired in details and confusion"
    - This suggests being stuck or hindered. The enzymes are not hindered; they are participating in a biological process. Doesn't fit.

 3. sense_key=involved%5:00:00:attached:01 | definition=emotionally involved
    - This refers to emotional attachment. Enzymes don't have emotions. Doesn't fit.

 4. sense_key=involved%5:00:00:complex:00 | definition=highly complex or intricate and occasionally devious | synonyms=Byzantine, convoluted, knotty, tangled, tortuous
    - This describes complexity. While the process might be complex, "involved" here describes participation, not complexity. Doesn't fit.

 5. sense_key=involved%5:00:00:enclosed:00 | definition=enveloped | examples="a castle involved in mist; the difficulties in which the question is involved"
    - This suggests being surrounded/enveloped. While one could say enzymes are "involved in" a process in the sense of being enveloped, the primary meaning here is participation/association, not physical envelopment.

 The best fit is sense 1: "connected by participation or association or use". The enzymes participate in/are associated with the production of nucleotides.

 The index requested is the number in the list: 1, 2, 3, 4, or 5.

 So the answer should be: {"sense_index": 1}

provider: ModelRun


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: produce
Target surface form: producing
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in <t>producing</t> nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=produce%2:36:02:: | definition=bring forth or yield | synonyms=bring forth | examples=The tree would not produce fruit
2. sense_key=produce%2:36:00:: | definition=create or manufacture a man-made product | synonyms=make, create | examples=We produce more cars than we can sell; The company has been making toys for two centuries
3. sense_key=produce%2:36:03:: | definition=cause to happen, occur or exist | synonyms=bring about, give rise | examples=This procedure produces a curious effect; The new law gave rise to many complaints
4. sense_key=produce%2:39:01:: | definition=bring out for display | synonyms=bring forth | examples=The proud father produced many pictures of his baby; The accused brought forth a letter in court that he claims exonerates him
5. sense_key=produce%2:36:05:: | definition=cultivate by growing, often involving improvements by means of agricultural techniques | synonyms=grow, raise, farm | examples=The Bordeaux region produces great red wines; They produce good ham in Parma
6. sense_key=produce%2:39:00:: | definition=bring onto the market or release | synonyms=bring on, bring out | examples=produce a movie; bring out a book
7. sense_key=produce%2:29:00:: | definition=come to have or undergo a change of (physical features and attributes) | synonyms=grow, develop, get, acquire | examples=He grew a beard; The patient developed abdominal pains

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation on the word "producing" in the given context.

 Context analysis:
 - The text is about Alimta (pemetrexed), a cytotoxic medicine/antimetabolite used for cancer treatment
 - The specific sentence: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in <t>producing</t> nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."
 - Here, "producing" refers to the biological/cellular process of creating/manufacturing nucleotides (DNA/RNA building blocks)
 - The enzymes are involved in the synthesis/creation of nucleotides

 Candidate sense analysis:

 1. sense_key=produce%2:36:02:: | definition=bring forth or yield | synonyms=bring forth | examples=The tree would not produce fruit
    - This is about natural yielding/giving forth, like plants producing fruit. While biological, the context here is about enzymatic synthesis of cellular components, which is more like manufacturing/creating.

 2. sense_key=produce%2:36:00:: | definition=create or manufacture a man-made product | synonyms=make, create | examples=We produce more cars than we can sell; The company has been making toys for two centuries
    - This is about manufacturing/creating products. While nucleotides aren't "man-made" in the industrial sense, this sense is often used for biological synthesis (cells producing proteins, enzymes producing substances). The examples show industrial manufacturing, but the definition "create or manufacture" fits well with enzymatic synthesis of nucleotides.

 3. sense_key=produce%2:36:03:: | definition=cause to happen, occur or exist | synonyms=bring about, give rise | examples=This procedure produces a curious effect; The new law gave rise to many complaints
    - This is about causing effects or outcomes, not about synthesizing physical substances like nucleotides.

 4. sense_key=produce%2:39:01:: | definition=bring out for display | synonyms=bring forth | examples=The proud father produced many pictures of his baby
    - This is about presenting/showing something, not relevant here.

 5. sense_key=produce%2:36:05:: | definition=cultivate by growing, often involving improvements by means of agricultural techniques | synonyms=grow, raise, farm | examples=The Bordeaux region produces great red wines
    - This is agricultural production, not relevant to cellular biochemistry.

 6. sense_key=produce%2:39:00:: | definition=bring onto the market or release | synonyms=bring on, bring out | examples=produce a movie; bring out a book
    - This is about releasing/publishing, not relevant.

 7. sense_key=produce%2:29:00:: | definition=come to have or undergo a change of (physical features and attributes) | synonyms=grow, develop | examples=He grew a beard
    - This is about personal growth/development, not relevant.

 Now, between sense 1 and sense 2:
 - Sense 1 (bring forth or yield) is often used for natural, organic production (trees producing fruit, animals producing offspring)
 - Sense 2 (create or manufacture) is used for making/creating things, including in biological contexts (cells producing proteins, enzymes producing compounds)

 In biological/medical contexts, when talking about enzymes synthesizing nucleotides, DNA, RNA, proteins, etc., the sense is typically "create or manufacture" (sense 2) or "bring forth" (sense 1).

 However, looking carefully:
 - Sense 1: "bring forth or yield" - often implies natural generation, yielding fruit, offspring, etc.
 - Sense 2: "create or manufacture a man-made product" - the examples are industrial, but WordNet often uses this for biological synthesis too.

 Actually, looking at WordNet's actual sense distinctions:
 - produce%2:36:00:: usually covers manufacturing, creating products (including biological products in modern usage)
 - produce%2:36:02:: usually covers yielding, bringing forth (like fruit, crops naturally)

 But in the context of "enzymes involved in producing nucleotides", this is about biochemical synthesis - the creation/manufacturing of nucleotides by enzymatic processes.

 However, I need to be careful. Let me reconsider the WordNet senses more carefully.

 In WordNet 3.0/3.1:
 - produce%2:36:00:: - create or manufacture a man-made product
 - produce%2:36:02:: - bring forth or yield

 The distinction is often that sense 2:36:00 involves deliberate creation/manufacturing (including by biological systems acting as machines), while 2:36:02 is more about natural yielding.

 But in many WSD datasets, biological synthesis (cells producing proteins) is often mapped to sense 2:36:00 (create/manufacture) or sometimes to sense 2:36:02.

 Let me look at the examples again:
 - Sense 1 example: "The tree would not produce fruit" - natural biological process
 - Sense 2 examples: "We produce more cars than we can sell" - industrial manufacturing

 The context here is about enzymes (biological catalysts) producing nucleotides. This is a biological synthetic process.

 However, in WordNet, "produce" when referring to biological synthesis (like producing DNA, proteins, nucleotides) is often sense 2:36:00 (create/manufacture) because it views the cell/enzyme as a factory manufacturing components.

 But wait, looking at the gloss for sense 1: "bring forth or yield" - this could also apply to biological production.

 Let me think about the specific context: "enzymes that are involved in producing nucleotides"
 - Enzymes catalyze the synthesis of nucleotides
 - This is a manufacturing/creating process at the molecular level

 Actually, looking at standard WSD practice for biological contexts:
 - When cells or organisms produce substances (proteins, chemicals, etc.), it's often sense 2:36:00 (create/manufacture)
 - When land/nature produces crops/fruit spontaneously, it's sense 2:36:02 or 2:36:05

 But there's a potential issue: sense 2 says "man-made product" - nucleotides are not man-made, they're natural biological molecules.

 However, WordNet senses are often extended. Sense 2:36:00 is the general "create/make" sense, while 2:36:02 is "yield/give forth".

 Let me reconsider sense 3: "cause to happen, occur or exist" - this is about causing effects, not creating physical entities.

 Actually, looking at the target: "producing nucleotides" - nucleotides are physical substances being synthesized.

 Between sense 1 and 2:
 - Sense 1 (bring forth or yield): The tree produces fruit. The cow produces milk.
 - Sense 2 (create or manufacture): The factory produces cars. The cell produces proteins.

 In modern biological usage, cells/enzymes "produce" compounds in the sense of manufacturing them (sense 2), even though they're not "man-made" in the sense of human-made. The WordNet gloss says "man-made" but this is often interpreted broadly in application, or the sense is used for any manufactured/created product including biological ones.

 However, looking at the exact WordNet 3.1 entries:
 - produce.v.01: create or manufacture a man-made product
 - produce.v.02: cause to happen, occur or exist
 - produce.v.03: bring forth or yield

 Wait, the numbering in the candidate senses might not match the standard WordNet order. Let me check the sense keys:
 - produce%2:36:00:: - this is produce.v.01 (create or manufacture)
 - produce%2:36:02:: - this is produce.v.03 (bring forth or yield)
 - produce%2:36:03:: - this is produce.v.02 (cause to happen)

 So:
 - Sense 1 in the list = produce.v.03 (bring forth or yield)
 - Sense 2 in the list = produce.v.01 (create or manufacture)
 - Sense 3 in the list = produce.v.02 (cause to happen)

 In the context of enzymes producing nucleotides, this is clearly a case of biological synthesis/manufacturing. The enzymes are manufacturing/creating nucleotides.

 However, "bring forth or yield" (sense 1) could also apply to biological generation.

 But looking at the examples:
 - Sense 1: "The tree would not produce fruit" - natural generation
 - Sense 2: "We produce more cars than we can sell" - manufacturing

 For enzymes producing nucleotides, this is more like manufacturing (biochemical synthesis) than like a tree yielding fruit. Enzymes are molecular machines that assemble nucleotides from precursors - this is manufacturing.

 Therefore, sense 2 (produce%2:36:00::) seems most appropriate.

 Wait, I should double-check if there's any other interpretation. Could it be sense 3 (cause to happen)? "producing nucleotides" - nucleotides are entities that come into existence, not just effects. So no.

 Sense 2 is the best fit.

 But let me reconsider sense 1 vs 2 one more time. In many WSD datasets, biological production (cells producing antibodies, etc.) is annotated as sense 2 (create/manufacture) because it involves active synthesis rather than passive yielding.

 Also, the phrase "involved in producing" suggests an active process of creation/synthesis, which aligns with "create or manufacture" rather than "bring forth" (which suggests emergence/yielding).

 Therefore, the answer should be sense_index: 2.

 Wait, I need to make sure about the indexing. The user lists:
 1. sense_key=produce%2:36:02::
 2. sense_key=produce%2:36:00::
 3. sense_key=produce%2:36:03::
 4. sense_key=produce%2:39:01::
 5. sense_key=produce%2:36:05::
 6. sense_key=produce%2:39:00::
 7. sense_key=produce%2:29:00::

 So sense 2 in the list is produce%2:36:00:: (create or manufacture).

 Yes, that's the one I want.

 Final check: Is there any chance it's sense 1 (bring forth or yield)?
 - "The tree would not produce fruit" - similar to enzymes producing nucleotides?
 - Both are biological, but fruit production is the natural end result of a plant's life cycle, whereas nucleotide production is a manufacturing process of molecular components.
 - Also, in the context of medicine and biochemistry, "produce" is used in the sense of synthesis/manufacture.

 I think sense 2 is correct.

provider: Novita


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: building_block
Target surface form: building blocks
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the <t>building blocks</t> of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=building_block%1:17:00:: | definition=a single undivided natural thing occurring in the composition of something else | synonyms=unit | examples=units of nucleic acids
2. sense_key=building_block%1:06:00:: | definition=a block of material used in construction work

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the target lemma "building_block" with the surface form "building blocks" in the given context.

 Let me analyze the context:
 - The text is about Alimta (pemetrexed), a cytotoxic medicine
 - It mentions that pemetrexed blocks enzymes involved in producing nucleotides
 - It describes nucleotides as "the building blocks of DNA and RNA"
 - DNA and RNA are described as "the genetic material of cells"

 Now let's look at the candidate senses:

 1. sense_key=building_block%1:17:00::
    - definition: a single undivided natural thing occurring in the composition of something else
    - synonyms: unit
    - examples: units of nucleic acids

 2. sense_key=building_block%1:06:00::
    - definition: a block of material used in construction work

 Analysis:
 - Sense 1 refers to a fundamental component or unit that makes up something else (like nucleotides making up DNA/RNA). The example specifically mentions "units of nucleic acids" which aligns with nucleotides being building blocks of DNA/RNA.
 - Sense 2 refers to physical construction materials (like bricks, concrete blocks used in building houses).

 In the context, "building blocks" is used metaphorically to describe nucleotides as the fundamental units/components that make up DNA and RNA. This is clearly Sense 1, not the physical construction sense.

 The context explicitly mentions "nucleotides (the building blocks of DNA and RNA)" - this is the biological/chemical sense where building blocks means fundamental components or units.

 Therefore, the correct sense is index 1.

 Wait, I need to check the format. The user wants me to return a JSON object like {"sense_index": 3}. But looking at the candidate senses, they are numbered 1 and 2. So I should return {"sense_index": 1}.

 Let me double-check:
 - Sense 1: building_block%1:17:00:: - unit/component sense
 - Sense 2: building_block%1:06:00:: - construction block sense

 Context: "nucleotides (the building blocks of DNA and RNA)" - definitely the component/unit sense, not physical construction.

 So the answer is {"sense_index": 1}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: genetic
Target surface form: genetic
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the <t>genetic</t> material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=genetic%5:00:00:inheritable:00 | definition=occurring among members of a family usually by heredity | synonyms=familial, hereditary, inherited, transmitted, transmissible | examples=an inherited disease; familial traits
2. sense_key=genetic%3:01:02:: | definition=of or relating to or produced by or being a gene | synonyms=genic, genetical | examples=genic combinations; genetic code
3. sense_key=genetic%3:01:01:: | definition=pertaining to or referring to origin | examples=genetic history reconstructs the origins of a literary work
4. sense_key=genetic%3:01:00:: | definition=of or relating to the science of genetics | synonyms=genetical | examples=genetic research

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 The user wants me to perform fine-grained Word Sense Disambiguation for the word "genetic" in a specific context.

 Context analysis:
 - The text is about Alimta (pemetrexed), a cytotoxic medicine/antimetabolite used for cancer treatment.
 - The specific sentence: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the <t>genetic</t> material of cells)."
 - Here, "genetic" is describing "material of cells" - specifically referring to DNA and RNA as the genetic material.
 - This is referring to the biological/genetic material that carries hereditary information.

 Candidate sense analysis:

 1. sense_key=genetic%5:00:00:inheritable:00 | definition=occurring among members of a family usually by heredity | synonyms=familial, hereditary, inherited, transmitted, transmissible | examples=an inherited disease; familial traits
    - This sense refers to inheritable traits/diseases. While DNA/RNA are involved in heredity, the phrase "genetic material" here is referring to the material itself (DNA/RNA), not specifically to the concept of inheritance or familial occurrence. This seems too narrow for "genetic material."

 2. sense_key=genetic%3:01:02:: | definition=of or relating to or produced by or being a gene | synonyms=genic, genetical | examples=genic combinations; genetic code
    - This sense relates to genes specifically. DNA and RNA are genetic material - they are the molecules that constitute genes and carry genetic information. "Genetic material" is a standard term referring to DNA/RNA. The examples include "genetic code" which is closely related to genetic material.

 3. sense_key=genetic%3:01:01:: | definition=pertaining to or referring to origin | examples=genetic history reconstructs the origins of a literary work
    - This is a more general sense about origins (etymological/genesis), like "genetic history" of a literary work. This doesn't fit the biological context of DNA/RNA.

 4. sense_key=genetic%3:01:00:: | definition=of or relating to the science of genetics | synonyms=genetical | examples=genetic research
    - This refers to the science/field of genetics (e.g., genetic research, geneticist). While related, "genetic material" is not talking about the science itself, but about the physical material (DNA/RNA) that is the subject of genetics.

 Comparison between sense 2 and sense 4:
 - Sense 2: "of or relating to or produced by or being a gene" - DNA and RNA are the genetic material, meaning the material that comprises genes or relates to genes.
 - Sense 4: "of or relating to the science of genetics" - This would be more appropriate for "genetic research," "genetic testing" (as a field), etc.

 The phrase "genetic material" specifically refers to the molecules (DNA, RNA) that carry genetic information - i.e., material relating to genes. This aligns best with sense 2: "of or relating to or produced by or being a gene."

 Also, looking at the gloss for sense 2: "of or relating to or produced by or being a gene" - genetic material is material that is produced by or constitutes genes, or relates to genes.

 Sense 1 is about inheritable traits, which is related but distinct from "genetic material" as a physical substance.

 Therefore, the best choice is sense 2 (genetic%3:01:02::).

 Wait, let me double-check the indexing. The user asks for the "sense_index" which appears to be the number in the list (1, 2, 3, or 4).

 So sense_index would be 2.

 Let me verify:
 - Sense 1: inheritable/familial - "genetic disease" would fit here, but "genetic material" is different.
 - Sense 2: relating to genes - "genetic code", "genetic material" fits here.
 - Sense 3: relating to origin - etymological.
 - Sense 4: relating to science of genetics - "genetic research".

 Yes, sense 2 is correct.

 Actually, looking at WordNet more carefully:
 - genetic%3:01:02:: usually maps to the "genic" sense - relating to genes.
 - genetic%3:01:00:: usually maps to the "genetical" sense - relating to genetics (the field).

 In the context: "the building blocks of DNA and RNA, the genetic material of cells"
 This refers to DNA and RNA being the material that constitutes the genes or carries genetic information. This is the "relating to genes" sense, not the "relating to the science" sense.

 Therefore, the answer is sense_index 2.

 Wait, I should check if "genetic material" could be sense 1 (inheritable). No, that doesn't make sense because:
 1. It's an adjective modifier "genetic" modifying "material"
 2. Sense 1 is specifically "occurring among members of a family usually by heredity" - this describes things like diseases or traits, not material.
 3. You wouldn't say "the inheritable material of cells" in this context - you're saying the material that contains genes/genetic information.

 So definitely sense 2.

 Final check:
 - Target: genetic
 - Context: DNA and RNA are the genetic material
 - Best sense: of or relating to or produced by or being a gene (sense 2)

 Output format: {"sense_index": 2}