[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: information
Target surface form: information
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more <t>information</t>, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=information%1:10:00:: | definition=a message received and understood | synonyms=info
2. sense_key=information%1:09:00:: | definition=knowledge acquired through study or experience or instruction
3. sense_key=information%1:10:02:: | definition=formal accusation of a crime
4. sense_key=information%1:14:00:: | definition=a collection of facts from which conclusions may be drawn | synonyms=data | examples=statistical data
5. sense_key=information%1:07:00:: | definition=(communication theory) a numerical measure of the uncertainty of an outcome | synonyms=selective information, entropy | examples=the signal contained thousands of bits of information

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 The user wants me to perform Word Sense Disambiguation for the word "information" in the given context.

 Context analysis:
 The text is about a medical drug called Alimta (pemetrexed). It describes dosing, side effects, contraindications, etc. The target sentence is: "For more <t>information</t>, see the Summary of Product Characteristics (also part of the EPAR)."

 This is a standard phrase "For more information..." which typically means "for more details/knowledge/data about this topic."

 Let's look at the candidate senses:

 1. sense_key=information%1:10:00:: | definition=a message received and understood | synonyms=info
    - This is a general sense of information as a message or communication.

 2. sense_key=information%1:09:00:: | definition=knowledge acquired through study or experience or instruction
    - This refers to knowledge gained through learning.

 3. sense_key=information%1:10:02:: | definition=formal accusation of a crime
    - This is a legal sense (e.g., "lay an information"), clearly not relevant here.

 4. sense_key=information%1:14:00:: | definition=a collection of facts from which conclusions may be drawn | synonyms=data | examples=statistical data
    - This refers to data, facts, statistics.

 5. sense_key=information%1:07:00:: | definition=(communication theory) a numerical measure of the uncertainty of an outcome | synonyms=selective information, entropy | examples=the signal contained thousands of bits of information
    - This is the technical information theory sense, clearly not relevant.

 Now between sense 1, 2, and 4.

 Sense 1 (message received and understood): This is a very general sense. "For more information" could fit here as "for more messages/details."

 Sense 2 (knowledge acquired...): This emphasizes the acquisition of knowledge through study/experience. While the Summary of Product Characteristics does contain knowledge, the phrase "for more information" in this context is pointing to a document that contains facts/data, not necessarily emphasizing the process of acquiring knowledge.

 Sense 4 (collection of facts... data): This seems very relevant. The Summary of Product Characteristics (SmPC) is a document containing factual data about the drug. The phrase "for more information" here means "for more factual details/data."

 However, let's look at typical usage. "For more information, see..." is an extremely common phrase. In WordNet, sense 1 (information%1:10:00::) is often the default sense for general usage of "information" as a message or communication content.

 But let's look more carefully at the definitions:

 Sense 1: "a message received and understood" - synonyms: info
 Sense 2: "knowledge acquired through study or experience or instruction"
 Sense 4: "a collection of facts from which conclusions may be drawn" - synonyms: data

 In the context of medical labeling and drug information, "information" refers to the factual content of the document (SmPC). This aligns well with sense 4 (data, collection of facts).

 However, sense 1 is also plausible as a general "message" or "details."

 Let me check WordNet's actual hierarchy:
 - information%1:10:00:: is under communication -> message
 - information%1:09:00:: is under cognition -> knowledge
 - information%1:14:00:: is under group -> collection (specifically "data" is the synonym)

 The phrase "For more information" is ambiguous between these, but in the context of referring to a technical document (Summary of Product Characteristics), it's asking for more factual data/details.

 But wait, looking at typical WSD datasets (like SemCor or Senseval), "information" in phrases like "for more information" or "contact us for information" is often tagged with sense 1 (the general communication sense) or sense 2 (knowledge).

 Actually, looking at WordNet examples:
 - Sense 1: "a message received and understood" - this is very general.
 - Sense 4: examples include "statistical data"

 The Summary of Product Characteristics is definitely a collection of facts/data. So sense 4 seems appropriate.

 But I need to be careful. In many WSD systems, "information" in the context of "more information" or "further information" referring to documents is often mapped to sense 1 or 2.

 Let me reconsider the distinction:
 - Sense 1 focuses on the communicative aspect (a message)
 - Sense 2 focuses on the cognitive aspect (knowledge gained)
 - Sense 4 focuses on the content as facts/data

 In "For more information, see the Summary of Product Characteristics", the reader is being directed to a source that contains factual data about the drug. This is essentially saying "For more facts/data/details..."

 However, sense 1 is the most frequent sense and is often used as a default. But the instruction says to use context, examples, and synonyms to choose the best.

 The context is medical/technical. The document referred to (Summary of Product Characteristics) is a regulatory document containing specific factual data about the medicine.

 Sense 4 (data, collection of facts) seems most precise here. The synonyms include "data" and the example mentions "statistical data". While the SmPC isn't just statistics, it is a structured collection of facts.

 But let me check if there's any reason to prefer sense 1. Sense 1 is "a message received and understood". Is the SmPC a message? Yes. Is it information in the sense of communication? Yes.

 However, sense 4 is more specific to factual content. In medical contexts, "information" often borders on "data".

 Actually, looking at the definition of sense 4 again: "a collection of facts from which conclusions may be drawn". This is the definition of "data" essentially. The SmPC provides facts about dosage, side effects, etc., from which healthcare providers draw conclusions about treatment.

 Sense 2: "knowledge acquired through study..." - this would imply the reader gains knowledge by reading it, which is true, but the phrase "for more information" refers to the content of the document, not the state of knowledge the reader will achieve.

 Between sense 1 and 4:
 - Sense 1 is more about the transmission/communication aspect.
 - Sense 4 is more about the factual content.

 In "For more information, see X", X is the location of the facts/data. So sense 4 seems better.

 However, I should verify if WordNet distinguishes these clearly. In many WSD tasks, sense 1 is the most common for general "information" usage.

 Let me think about the examples provided for sense 4: "statistical data". This suggests sense 4 is quite specific to data in the sense of statistics or datasets.

 The SmPC is not just raw data; it's structured information. But it is factual.

 Actually, looking at the synsets:
 - information%1:10:00:: (message) - hypernym: message, content, subject matter
 - information%1:14:00:: (data) - hypernym: collection, aggregation

 The phrase "for more information" is extremely common. In the SemCor corpus (WordNet tagged), how is it tagged?

 I recall that "information" is highly polysemous but sense 1 is the most frequent. However, sense 4 is distinct as "data".

 Let me reconsider the context. The text is describing a drug. It says "For more information, see the Summary of Product Characteristics". This is a standard regulatory phrase. The SmPC contains comprehensive factual data about the drug.

 If I have to choose between "a message" (sense 1) and "a collection of facts/data" (sense 4), I think sense 4 is more accurate because:
 1. The context is technical/medical
 2. The reference is to a detailed factual document (SmPC)
 3. "Data" (synonym for sense 4) fits well here, whereas "message" (sense 1) is a bit too general and communicative-focused.

 However, sense 2 (knowledge) could also work: "For more knowledge..."

 But sense 4 specifically mentions "facts" and "data", which aligns with the nature of a Product Characteristics summary.

 Wait, I should look at the actual WordNet entries to see the hyponyms or examples to be sure.

 Sense 1 examples (from WordNet): "he awaited news of the outcome"
 Sense 2 examples: "the instructions provided little enlightenment"
 Sense 4 examples: "statistical data"

 The phrase "For more information" is so generic that it could be sense 1. But given the specific context of a drug label referring to a technical document, sense 4 (data/facts) is more precise.

 But I'm concerned that sense 4 might be too narrow (specifically for statistical/data contexts). Let me reconsider.

 Actually, looking at the definition of sense 4: "a collection of facts from which conclusions may be drawn". This is the definition of "data". The SmPC is indeed a collection of facts from which medical professionals draw conclusions.

 Sense 1: "a message received and understood" - this emphasizes the communicative act. While the SmPC communicates, the phrase "for more information" in this context is asking for the factual content, not just any message.

 I think sense 4 is the best choice.

 Wait, I should check if there's any possibility of sense 0 (not listed) or if I'm missing something. The senses listed are 1, 2, 3, 4, 5 (indexed as 1,2,3,4,5 in the candidate list).

 The user asks for the "best indexed sense". The indices are:
 1. sense_key=information%1:10:00::
 2. sense_key=information%1:09:00::
 3. sense_key=information%1:10:02::
 4. sense_key=information%1:14:00::
 5. sense_key=information%1:07:00::

 So if I choose sense 4 (data), the index is 4.

 If I choose sense 1 (message), the index is 1.

 Let me double-check by searching my internal knowledge of WordNet sense frequencies and typical disambiguation.

 In the sentence "For more information, call 1-800...", this is usually sense 1 (general info) or sense 2.

 But in "process this information", it could be sense 4 (data).

 Here, "see the Summary of Product Characteristics" - the SmPC is a structured dataset of drug properties. This strongly suggests sense 4.

 Also, the presence of the example "statistical data" for sense 4 suggests it's for structured factual content, which matches a drug monograph.

 Therefore, I will choose index 4.

 But let me reconsider sense 2 one more time. "Knowledge acquired through study..." - the SmPC is a source of knowledge, but the phrase "for more information" refers to the object (the info itself), not the resulting knowledge state. Sense 2 focuses on the acquisition: "knowledge acquired...". The phrase "for more information" doesn't emphasize the acquisition process, but the availability of facts.

 So sense 4 is better than sense 2.

 Between 1 and 4: Sense 1 is too broad. Sense 4 captures the factual, data-like nature of the drug information.

 Final decision: index 4.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: see
Target surface form: see
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=see%2:39:00:: | definition=perceive by sight or have the power to perceive by sight | examples=You have to be a good observer to see all the details; Can you see the bird in that tree?
2. sense_key=see%2:31:01:: | definition=perceive (an idea or situation) mentally | synonyms=understand, realize, realise | examples=Now I see!; I just can't see your point
3. sense_key=see%2:39:02:: | definition=perceive or be contemporaneous with | synonyms=witness, find | examples=We found Republicans winning the offices; You'll see a lot of cheating in this school
4. sense_key=see%2:36:00:: | definition=imagine; conceive of; see in one's mind | synonyms=visualize, visualise, envision, project, fancy, figure | examples=I can't see him on horseback!; I can see what will happen
5. sense_key=see%2:31:00:: | definition=deem to be | synonyms=consider, reckon, view, regard | examples=She views this quite differently from me; I consider her to be shallow
6. sense_key=see%2:31:02:: | definition=get to know or become aware of, usually accidentally | synonyms=learn, hear, get word, get wind, pick up, find out | examples=I learned that she has two grown-up children; I see that you have been promoted
7. sense_key=see%2:39:03:: | definition=see or watch | synonyms=watch, view, catch, take in | examples=view a show on television; This program will be seen all over the world
8. sense_key=see%2:38:00:: | definition=come together | synonyms=meet, run into, encounter, run across, come across | examples=I'll probably see you at the meeting; How nice to see you again!
9. sense_key=see%2:32:00:: | definition=find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, find out, ascertain, watch, learn | examples=I want to see whether she speaks French; See whether it works
10. sense_key=see%2:31:03:: | definition=be careful or certain to do something; make certain of something | synonyms=check, insure, see to it, ensure, control, ascertain | examples=He verified that the valves were closed; See that the curtains are closed
11. sense_key=see%2:41:11:: | definition=go to see for professional or business reasons | examples=You should see a lawyer; We had to see a psychiatrist
12. sense_key=see%2:41:12:: | definition=go to see for a social visit | examples=I went to see my friend Mary the other day
13. sense_key=see%2:41:10:: | definition=go to see a place, as for entertainment | synonyms=visit | examples=We went to see the Eiffel Tower in the morning
14. sense_key=see%2:41:14:: | definition=take charge of or deal with | synonyms=attend, take care, look | examples=Could you see about lunch?; I must attend to this matter
15. sense_key=see%2:35:09:: | definition=receive as a specified guest | examples=the doctor will see you now; The minister doesn't see anybody before noon
16. sense_key=see%2:41:00:: | definition=date regularly; have a steady relationship with | synonyms=go steady, go out, date | examples=Did you know that she is seeing an older man?; He is dating his former wife again!
17. sense_key=see%2:39:05:: | definition=see and understand, have a good eye | examples=The artist must first learn to see
18. sense_key=see%2:31:08:: | definition=deliberate or decide | examples=See whether you can come tomorrow; let's see--which movie should we see tonight?
19. sense_key=see%2:39:11:: | definition=observe as if with an eye | examples=The camera saw the burglary and recorded it
20. sense_key=see%2:39:13:: | definition=observe, check out, and look over carefully or inspect | synonyms=examine | examples=The customs agent examined the baggage; I must see your passport before you can enter the country
21. sense_key=see%2:39:12:: | definition=go or live through | synonyms=experience, go through | examples=We had many trials to go through; he saw action in Viet Nam
22. sense_key=see%2:38:03:: | definition=accompany or escort | synonyms=escort | examples=I'll see you to the door
23. sense_key=see%2:33:00:: | definition=match or meet | examples=I saw the bet of one of my fellow players
24. sense_key=see%2:31:13:: | definition=make sense of; assign a meaning to | synonyms=interpret, construe | examples=What message do you see in this letter?; How do you interpret his behavior?

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

finish_reason: stop

role: assistant

reasoning_content:
 The user wants me to perform Word Sense Disambiguation for the word "see" in the given context.

Context analysis:
The sentence is: "For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR)."

This is a common phrase in medical/technical documentation. "See" here means to refer to or consult another document for additional information. It's directing the reader to look at another source.

Looking at the candidate senses:

1. sense_key=see%2:39:00:: - perceive by sight (literal seeing) - not quite right, though related
2. sense_key=see%2:31:01:: - perceive mentally/understand - not quite
3. sense_key=see%2:39:02:: - witness/find - not quite
4. sense_key=see%2:36:00:: - imagine/visualize - no
5. sense_key=see%2:31:00:: - deem to be/consider - no
6. sense_key=see%2:31:02:: - get to know/become aware (learn) - close, but "see" here is more about referring to a source
7. sense_key=see%2:39:03:: - see or watch (view) - could be close, but usually implies visual watching
8. sense_key=see%2:38:00:: - come together/meet - no
9. sense_key=see%2:32:00:: - find out/learn/determine - possible, but usually involves inquiry
10. sense_key=see%2:31:03:: - be careful/certain (see to it) - no
11. sense_key=see%2:41:11:: - go to see for professional reasons - no
12. sense_key=see%2:41:12:: - go to see for social visit - no
13. sense_key=see%2:41:10:: - go to see a place (visit) - no
14. sense_key=see%2:41:14:: - take charge of/deal with (see about) - no, though "see about" is different from "see the Summary"
15. sense_key=see%2:35:09:: - receive as a guest - no
16. sense_key=see%2:41:00:: - date regularly - no
17. sense_key=see%2:39:05:: - see and understand (have a good eye) - no
18. sense_key=see%2:31:08:: - deliberate or decide - no
19. sense_key=see%2:39:11:: - observe as if with an eye - no
20. sense_key=see%2:39:13:: - observe/check out/inspect/examine - this is close. "See" here means to look at/refer to/examine the document.
21. sense_key=see%2:39:12:: - go or live through (experience) - no
22. sense_key=see%2:38:03:: - accompany/escort - no
23. sense_key=see%2:33:00:: - match or meet (cards) - no
24. sense_key=see%2:31:13:: - make sense of/interpret - no

Wait, I need to look more carefully. The phrase "see the Summary of Product Characteristics" is similar to "see page 10" or "see the appendix". This is a reference sense.

Looking at the options again:

Sense 20: see%2:39:13:: definition=observe, check out, and look over carefully or inspect | synonyms=examine | examples=The customs agent examined the baggage; I must see your passport before you can enter the country

This seems like "inspect" or "look at", which could work for "see the document".

But there's also:
Sense 7: see%2:39:03:: definition=see or watch | synonyms=watch, view, catch, take in | examples=view a show on television; This program will be seen all over the world

Sense 1: see%2:39:00:: perceive by sight...

Actually, looking at WordNet, the sense "see" meaning "refer to" or "consult" might be missing from this list, or it might be covered by one of these.

Let me reconsider sense 6: see%2:31:02:: definition=get to know or become aware of, usually accidentally | synonyms=learn, hear, get word, get wind, pick up, find out | examples=I learned that she has two grown-up children; I see that you have been promoted

And sense 9: see%2:32:00:: definition=find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, find out, ascertain, watch, learn | examples=I want to see whether she speaks French; See whether it works

But "see the Summary" is not about finding out or learning in the sense of discovering information through inquiry, but rather directing the reader to look at a specific reference.

Actually, looking at standard WSD for "see" in "see X" where X is a reference work (like "see the dictionary", "see page 5"), this is often sense 1 (perceive by sight) used metaphorically, or it could be sense 20 (examine/inspect).

But wait, looking at the examples for sense 20: "The customs agent examined the baggage; I must see your passport before you can enter the country" - this is about inspecting physically.

For "see" in bibliographic/reference contexts ("see also", "see page 10"), WordNet often treats this as sense 1 (perceive by sight) or sometimes as sense 7 (view/watch).

But actually, looking carefully at the list, I don't see a specific "refer to" sense. However, sense 20 (examine, inspect) or sense 7 (view, watch) could cover it.

Wait, there's also sense 2: perceive mentally/understand - "Now I see!"

Let me think about the context again. "For more information, see the Summary of Product Characteristics..." This is a cross-reference. In WordNet, this is typically handled by sense 1 (perceive by sight) as the primary literal sense extended to written references, or possibly sense 39:13 (examine).

But looking at the examples for sense 39:13: "I must see your passport" - this is about looking at a document to verify. "See the Summary" is about consulting a document for information.

Actually, looking at WordNet 3.0 or 3.1, the sense "see" for referring to written material is often sense 1 (perceive by sight) or sense 7 (view).

But there's another possibility: sense 6 (learn, find out) - "I see that you have been promoted" - this is about becoming aware.

Or sense 9 (determine, check, find out) - "See whether it works".

But "see the Summary" is not "see whether..." or "see that...".

Let me look at sense 20 again: "observe, check out, and look over carefully or inspect". The example "I must see your passport" is very similar to "see the Summary of Product Characteristics" - both involve looking at a document to get information.

However, in the context of "For more information, see...", it's a directive to the reader to consult the referenced document. This is a very common usage.

Looking at the candidate list, sense 20 (see%2:39:13::) seems the closest with "examine" and the passport example.

But I should also consider sense 7 (see%2:39:03::) with "view" and the example "This program will be seen all over the world" - this is about viewing content.

Actually, looking at standard WordNet sense inventories for "see", the sense used for "see the dictionary" or "see page 5" is typically:
- see%2:39:00:: (perceive by sight) - the basic sense
OR
- see%2:39:03:: (view, watch)

But given the specific example in sense 20 about seeing a passport (a document), and the definition including "examine", this seems like a strong candidate.

However, looking at the fine-grained distinctions, "see" in "see the Summary of Product Characteristics" is an instruction to look at or consult that document. This is similar to "see your doctor" (sense 11) but that's for professional reasons.

Wait, sense 11 is "go to see for professional or business reasons" - examples: "You should see a lawyer". This is about visiting a person, not consulting a document.

Sense 20: "examine" - "I must see your passport". This is examining a document.

Sense 7: "view" - "view a show on television".

Between 7 and 20, sense 20 seems more appropriate because it involves examining/looking at something specific to get information, whereas sense 7 is more about watching/viewing as entertainment or broadcast.

But actually, looking at the WordNet hierarchy, sense 20 (examine) is a hyponym of sense 7 (perceive visually)? No, looking at the sense keys:
- 2:39:00 is the root perception sense
- 2:39:03 is "see or watch" (view)
- 2:39:13 is "observe, check out, and look over carefully or inspect" (examine)

Given the context is medical documentation referring to another document, and the example in sense 20 involves seeing a passport (official document), sense 20 appears to be the best fit.

But I need to be careful. Is there a sense specifically for "refer to"? Looking at the list provided, I don't see "refer" or "consult" explicitly.

Let me reconsider sense 6: "get to know or become aware of, usually accidentally" - synonyms include learn, hear, find out. Example: "I see that you have been promoted". This is about understanding or learning.

Sense 2: "perceive (an idea or situation) mentally" - understand.

Sense 24: "make sense of; assign a meaning to" - interpret.

None of these fit perfectly.

Sense 20 with "examine" and the passport example seems the most concrete match for looking at a document.

However, I should verify if "see" in "see the instructions" is typically tagged as sense 1 (basic sight) or sense 20 (examine) in WordNet corpora.

In many WSD datasets, "see" referring to written material (like "see below", "see the manual") is often annotated with the basic visual sense (sense 1) or the "examine" sense (sense 20) depending on whether it's casual looking or careful examination.

Given the context is formal medical text ("Summary of Product Characteristics"), and it's about consulting detailed information, sense 20 (examine, inspect) seems more appropriate than just basic perception (sense 1).

But looking at the example for sense 1: "You have to be a good observer to see all the details" - this involves careful looking.

Actually, looking at the distinction:
- Sense 1: perceive by sight (basic)
- Sense 20: observe, check out, and look over carefully or inspect (examine)

"See the Summary of Product Characteristics" is an instruction to consult the document. This is similar to "see your doctor" (sense 11) but for a document. Since sense 11 is for people, and sense 20 has the passport example (document), sense 20 is better.

Also, sense 7 (view/watch) has examples about television programs, which is different from consulting a reference document.

Therefore, I choose sense 20 (index 20).

Wait, I need to check the indexing. The user lists them as 1, 2, 3... 24. So sense_key=see%2:39:13:: is index 20.

Let me double-check if there's any other sense that could fit better.

Sense 14: "take charge of or deal with" - "see about". But here it's "see the Summary", not "see about the Summary".

Sense 10: "be careful or certain to do something; make certain of something" - "see to it". Not matching.

Sense 18: "deliberate or decide" - "See whether you can come". Not matching.

So yes, between sense 1 (basic sight) and sense 20 (examine/inspect), sense 20 is more specific and fits better with the example of examining a passport/document.

Final decision: index 20.

format: unknown

native_finish_reason: stop

provider: Chutes

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: product
Target surface form: Product
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=product%1:06:01:: | definition=commodities offered for sale | synonyms=merchandise, ware | examples=good business depends on having good merchandise; that store offers a variety of products
2. sense_key=product%1:06:00:: | definition=an artifact that has been created by someone or some process | synonyms=production | examples=they improve their product every year; they export most of their agricultural production
3. sense_key=product%1:09:00:: | definition=a quantity obtained by multiplication | synonyms=mathematical product | examples=the product of 2 and 3 is 6
4. sense_key=product%1:27:00:: | definition=a chemical substance formed as a result of a chemical reaction | examples=a product of lime and nitric acid
5. sense_key=product%1:19:00:: | definition=a consequence of someone's efforts or of a particular set of circumstances | examples=skill is the product of hours of practice; his reaction was the product of hunger and fatigue
6. sense_key=product%1:14:00:: | definition=the set of elements common to two or more sets | synonyms=intersection, Cartesian product | examples=the set of red hats is the intersection of the set of hats and the set of red things

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 The user wants me to perform Word Sense Disambiguation for the word "product" in the given context. The target surface form is "Product" (capitalized) appearing in the phrase "Summary of Product Characteristics".

Let me analyze the context:
- The text is about a medication called Alimta (pemetrexed)
- It discusses medical treatment, intravenous infusions, side effects, etc.
- The specific phrase is "Summary of Product Characteristics (also part of the EPAR)"
- EPAR stands for European Public Assessment Report, which is a document related to pharmaceutical products in the EU.
- "Summary of Product Characteristics" (SmPC) is a standard medical/pharmaceutical term referring to the official datasheet for a medicinal product.

Now let's look at the candidate senses:

1. **product%1:06:01::** - commodities offered for sale (merchandise, ware)
   - Examples: good business depends on having good merchandise; that store offers a variety of products
   - This is the general commercial sense of goods for sale.

2. **product%1:06:00::** - an artifact that has been created by someone or some process (production)
   - Examples: they improve their product every year; they export most of their agricultural production
   - This is a general sense of something produced/manufactured.

3. **product%1:09:00::** - a quantity obtained by multiplication (mathematical product)
   - Examples: the product of 2 and 3 is 6
   - Mathematical sense - clearly not applicable here.

4. **product%1:27:00::** - a chemical substance formed as a result of a chemical reaction
   - Examples: a product of lime and nitric acid
   - Chemical sense - could be relevant since we're talking about a drug, but "Summary of Product Characteristics" refers to the drug as a whole commercial/medical product, not specifically as a chemical reaction product.

5. **product%1:19:00::** - a consequence of someone's efforts or of a particular set of circumstances
   - Examples: skill is the product of hours of practice; his reaction was the product of hunger and fatigue
   - Abstract/figurative sense - not applicable to a pharmaceutical product datasheet.

6. **product%1:14:00::** - the set of elements common to two or more sets (intersection, Cartesian product)
   - Mathematical/set theory sense - not applicable.

Now, the phrase "Summary of Product Characteristics" is specifically referring to the medical product (the drug Alimta). In pharmaceutical contexts, "product" typically refers to the medication itself as a commercial/manufactured item.

Between sense 1 (commodities offered for sale) and sense 2 (an artifact that has been created by someone or some process):

Sense 1 focuses on commercial goods for sale (merchandise).
Sense 2 focuses on something created/produced (an artifact).

In the context of "Summary of Product Characteristics" for a pharmaceutical drug, this is referring to the drug as a medicinal product - it's an artifact/creation (manufactured drug), but also a commercial product.

However, looking at the examples:
- Sense 1 examples: "good business depends on having good merchandise; that store offers a variety of products" - This is more about retail/consumer goods.
- Sense 2 examples: "they improve their product every year; they export most of their agricultural production" - This is about things produced/created.

In pharmaceutical regulatory contexts, "product" refers to the specific medicinal preparation (the artifact created by a process). The "Summary of Product Characteristics" describes the properties and usage of this specific medicinal artifact.

But I need to be careful. In WordNet, sense 1:06:01 is specifically "commodities offered for sale" which is goods/wares. Sense 1:06:00 is "an artifact that has been created by someone or some process."

A pharmaceutical product is both, but which sense fits better?

Actually, looking at the specific phrase "Summary of Product Characteristics" - this is a standard EU regulatory term (SmPC). In this context, "product" refers to the medicinal product (the drug Alimta).

Sense 2 (product%1:06:00) - "an artifact that has been created by someone or some process" - this seems like it could apply to manufactured drugs.

Sense 1 (product%1:06:01) - "commodities offered for sale" - this emphasizes the commercial aspect.

However, in medical/pharmaceutical English, when we refer to a "medicinal product" or just "product" in regulatory documents, we're typically using sense 2 (something produced/manufactured) rather than sense 1 (merchandise/wares for sale).

But wait, let me reconsider. The word "Product" appears in "Summary of Product Characteristics" which is a specific technical term. The drug Alimta is both:
- A commodity offered for sale (sense 1)
- An artifact created by a process (sense 2)

However, looking at the WordNet definitions carefully:
- Sense 1: "commodities offered for sale" - synonyms: merchandise, ware. This is about goods, stuff sold in stores.
- Sense 2: "an artifact that has been created by someone or some process" - synonyms: production. This is about the result of production.

A pharmaceutical drug is definitely an artifact created by a process (manufacturing). It is also a commodity, but in the medical context of EPAR (European Public Assessment Report) and SmPC (Summary of Product Characteristics), the focus is on the manufactured medicinal preparation.

Actually, looking at typical WordNet sense distinctions, sense 1 (product%1:06:01) is the hypernym of "software product", "book", etc. in the commercial goods sense. Sense 2 (product%1:06:00) is more general - anything produced.

But I should look at the actual WordNet hierarchy to be sure. In WordNet 3.0/3.1:
- product%1:06:01:: is under "commodity, trade goods, goods"
- product%1:06:00:: is under "artifact, artefact"

A drug is an artifact. But is it a "commodity offered for sale"? Yes, but in the specific medical context of "Summary of Product Characteristics", it's referring to the drug as a therapeutic agent - the manufactured pharmaceutical preparation.

Let me consider if sense 4 might be relevant: "a chemical substance formed as a result of a chemical reaction". While drugs are chemicals, the phrase "Summary of Product Characteristics" refers to the drug product as a whole (the preparation), not specifically as a chemical reaction product. Also, the example "a product of lime and nitric acid" suggests this is about chemical reaction products, not manufactured pharmaceuticals.

I think the choice is between sense 1 and sense 2.

In the context of "Summary of Product Characteristics" for a medicine:
- This is standard regulatory terminology
- The "product" is the medicinal product (the drug)
- In pharmaceutical regulation, this refers to the specific formulation/manufactured item

Sense 2 seems more appropriate because:
1. It emphasizes the artifact/creation aspect rather than the commercial/merchandise aspect
2. While drugs are sold, the SmPC is about the characteristics of the drug itself (its composition, effects, etc.) as a manufactured item
3. Sense 1's synonyms "merchandise, ware" sound more like general consumer goods in a store, whereas a pharmaceutical product is a specific type of manufactured artifact

However, I should check if there's any specific information about how these senses are distinguished in WordNet.

Sense 1: commodities offered for sale - this is the sense used when talking about "consumer products", "dairy products", etc. in a commercial context.

Sense 2: an artifact that has been created by someone or some process - this is broader and includes things that might not be for sale, or emphasizes the production aspect.

Actually, looking at the examples for sense 2: "they improve their product every year; they export most of their agricultural production" - the first example treats "product" as something that can be improved (like a manufactured good or software), the second explicitly mentions agricultural production.

The phrase "Summary of Product Characteristics" treats the drug as a product that has characteristics (chemical, pharmacological, etc.). This aligns with sense 2 - the artifact view.

Also, consider that sense 1 is specifically about commodities (goods for sale), while sense 2 is about artifacts (created things). In the medical/pharmaceutical domain, "medicinal product" is a specific term referring to the prepared medicine.

I believe sense 2 (product%1:06:00::) is the correct choice.

Wait, let me double-check by looking at the exact wording again: "Summary of Product Characteristics (also part of the EPAR)".

EPAR = European Public Assessment Report, which is the document for authorized medicines in the EU. The SmPC is part of this.

The drug Alimta is the "product" here. It's a pharmaceutical product.

In WordNet, which sense would "pharmaceutical product" fall under? Likely sense 2, as it's an artifact created by a process, though it could also be sense 1 as a commodity.

But given that sense 1 is defined as "commodities offered for sale" with synonyms "merchandise, ware", and the context is medical/regulatory rather than commercial/retail, sense 2 seems more fitting.

However, I want to reconsider sense 1. Is a drug a "commodity offered for sale"? Yes. But is that the specific sense being invoked in "Summary of Product Characteristics"?

Actually, looking at this from a lexicographic perspective, "product" in the phrase "medicinal product" or in drug documentation typically maps to sense 1:06:00 (artifact) rather than 1:06:01 (commodity).

Let me verify by checking if there's any distinction in the hypernyms:
- Sense 1 (1:06:01) -> commodity, trade goods, goods
- Sense 2 (1:06:00) -> artifact, artefact

A medicinal product is definitely an artifact. Is it a "commodity"? Technically yes, but WordNet sense 1 is specifically for the commercial aspect.

Actually, looking at similar disambiguation tasks, "product" referring to a specific manufactured item (like a car model, software, or drug) usually maps to sense 2 (artifact), while "product" referring to goods in a store or product categories maps to sense 1.

Example: "This factory produces chemical products" - sense 2 (artifacts).
"This store sells beauty products" - could be sense 1 (commodities).

But "Summary of Product Characteristics" is about the intrinsic properties of the drug ( artifact), not its commercial availability.

Therefore, I choose sense 2 (index 2 in the list, which is product%1:06:00::).

Wait, I need to check the indexing. The user lists:
1. sense_key=product%1:06:01::
2. sense_key=product%1:06:00::
3. sense_key=product%1:09:00::
4. sense_key=product%1:27:00::
5. sense_key=product%1:19:00::
6. sense_key=product%1:14:00::

So:
- Index 1: commodities offered for sale
- Index 2: an artifact that has been created by someone or some process
- Index 3: mathematical product
- Index 4: chemical substance from reaction
- Index 5: consequence of efforts
- Index 6: set intersection

My choice is index 2.

But let me reconsider sense 4 just to be thorough. Sense 4 is "a chemical substance formed as a result of a chemical reaction". While Alimta is a chemical, and it's synthesized by chemical reactions, the phrase "Summary of Product Characteristics" refers to the drug preparation as a whole (which includes the active substance and excipients, presentation, packaging, etc.), not specifically as a product of a chemical reaction. The example "a product of lime and nitric acid" is clearly about chemical reaction products. The SmPC is not describing the chemical reaction product aspect specifically, but rather the pharmaceutical product as a therapeutic agent. So sense 4 is not correct.

Between 1 and 2, I maintain that 2 is better because:
1. The context is medical/scientific describing treatment, side effects, mechanism - focused on the drug as a therapeutic entity (artifact), not as merchandise
2. "Summary of Product Characteristics" describes the intrinsic properties of the medicinal preparation
3. Sense 1 emphasizes "offered for sale" which is secondary in this regulatory/medical context

Therefore, the answer should be {"sense_index": 2}.

provider: DigitalOcean


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: part
Target surface form: part
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=part%1:24:00:: | definition=something determined in relation to something that includes it | synonyms=portion, component part, component, constituent | examples=he wanted to feel a part of something bigger than himself; I read a portion of the manuscript
2. sense_key=part%1:06:00:: | definition=something less than the whole of a human artifact | synonyms=portion | examples=the rear part of the house; glue the two parts together
3. sense_key=part%1:17:00:: | definition=a portion of a natural object | synonyms=piece | examples=they analyzed the river into three parts; he needed a piece of granite
4. sense_key=part%1:09:02:: | definition=that which concerns a person with regard to a particular role or situation | examples=it requires vigilance on our part; they resisted every effort on his part
5. sense_key=part%1:15:00:: | definition=the extended spatial location of something | synonyms=region | examples=the farming regions of France; religions in all parts of the world
6. sense_key=part%1:04:01:: | definition=the actions and activities assigned to or required or expected of a person or group | synonyms=function, office, role | examples=the function of a teacher; the government must do its part
7. sense_key=part%1:09:01:: | definition=an actor's portrayal of someone in a play | synonyms=character, role, theatrical role, persona | examples=she played the part of Desdemona
8. sense_key=part%1:21:00:: | definition=assets belonging to or due to or contributed by an individual person or group | synonyms=share, portion, percentage | examples=he wanted his share in cash
9. sense_key=part%1:09:00:: | definition=one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division | examples=the written part of the exam; the finance section of the company
10. sense_key=part%1:08:01:: | definition=a line of scalp that can be seen when sections of hair are combed in opposite directions | synonyms=parting | examples=his part was right in the middle
11. sense_key=part%1:10:00:: | definition=the melody carried by a particular voice or instrument in polyphonic music | synonyms=voice | examples=he tried to sing the tenor part
12. sense_key=part%1:04:03:: | definition=the part played by a person in bringing about a result | synonyms=contribution, share | examples=I am proud of my contribution in advancing the project; they all did their share of the work

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 The user wants me to perform Word Sense Disambiguation (WSD) on the word "part" in the given context.

Context analysis:
The sentence is: "For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR)."

Breaking down the context:
- EPAR stands for European Public Assessment Report (a document related to pharmaceutical products)
- The Summary of Product Characteristics is being described as "part of the EPAR"
- This means the Summary of Product Characteristics is a component or section of the larger document (EPAR)

Looking at the candidate senses:

1. sense_key=part%1:24:00:: - "something determined in relation to something that includes it" - This is a very general relational sense. Examples include "component part", "constituent". This could fit but let's check others.

2. sense_key=part%1:06:00:: - "something less than the whole of a human artifact" - This refers to physical artifacts (like parts of a house). The EPAR is a document/information artifact, but this sense seems focused on physical objects.

3. sense_key=part%1:17:00:: - "a portion of a natural object" - Examples: piece of granite. Not applicable here.

4. sense_key=part%1:09:02:: - "that which concerns a person with regard to a particular role or situation" - Examples: "on our part", "on his part". This is about responsibility or involvement. Not fitting.

5. sense_key=part%1:15:00:: - "the extended spatial location of something" - Geographic regions. Not applicable.

6. sense_key=part%1:04:01:: - "the actions and activities assigned to or required or expected of a person or group" - Role/function. Not applicable.

7. sense_key=part%1:09:01:: - "an actor's portrayal of someone in a play" - Theatrical role. Not applicable.

8. sense_key=part%1:21:00:: - "assets belonging to or due to or contributed by an individual person or group" - Share/percentage. Not applicable.

9. sense_key=part%1:09:00:: - "one of the portions into which something is regarded as divided and which together constitute a whole" - Synonyms: section, division. Examples: "the written part of the exam", "the finance section of the company". This fits well - the Summary of Product Characteristics is a section/portions of the EPAR document.

10. sense_key=part%1:08:01:: - "a line of scalp..." - Hair parting. Not applicable.

11. sense_key=part%1:10:00:: - "the melody carried by a particular voice..." - Musical part. Not applicable.

12. sense_key=part%1:04:03:: - "the part played by a person in bringing about a result" - Contribution. Not applicable.

Comparing sense 1 and sense 9:
Sense 1 (part%1:24:00::) is very abstract - "something determined in relation to something that includes it". It's a meronymic relation (part-whole).
Sense 9 (part%1:09:00::) is more specific to abstract divisions/sections of documents or organized wholes - "one of the portions into which something is regarded as divided and which together constitute a whole".

The example for sense 9: "the written part of the exam", "the finance section of the company" - these are clearly about sections of documents or organizational structures.

The example for sense 1: "he wanted to feel a part of something bigger than himself" - this is more about belonging/being a component in an abstract sense.

Given that the EPAR is a document/report and the Summary of Product Characteristics is a section/component of that document, sense 9 seems most appropriate. It's similar to "the written part of the exam" or "finance section of the company".

However, let me check sense 1 more carefully. The gloss is "something determined in relation to something that includes it" - this is the most general part-whole relation. The examples include "component part" and "constituent".

Sense 9 is specifically about portions into which something is divided that constitute a whole. This is specifically about sections/divisions.

In the context of documents, we typically say a section is "part of" a document. Both could work, but sense 9 (section, division) seems more precise for document structure.

Wait, let me look at WordNet hierarchy:
Sense 1: noun.Tops (the most general sense) - part%1:24:00:: - part, portion, component part, component, constituent
Sense 9: noun.cognition - part%1:09:00:: - part, section, division

Actually, looking at the sense keys:
part%1:24:00:: - This is under noun.Tops (lexicographer file noun.Tops) - the most general part-whole relation.
part%1:09:00:: - This is under noun.cognition - refers to sections/divisions of a whole.

The context refers to a document (EPAR) and a component of it (Summary of Product Characteristics). In WordNet, documents are often handled under noun.artifact or noun.communication.

Let me reconsider sense 2: "something less than the whole of a human artifact" - examples: "the rear part of the house", "glue the two parts together". This is physical.

But documents can be considered artifacts. However, sense 2 examples suggest physical objects.

Sense 9 seems best: "one of the portions into which something is regarded as divided and which together constitute a whole" with examples like "the written part of the exam", "the finance section of the company".

The Summary of Product Characteristics is indeed a section/division of the EPAR document.

Sense 1 is also possible but more general. Sense 9 is more specific to the idea of a document section.

Actually, looking at the examples for sense 1 again: "he wanted to feel a part of something bigger than himself" - this is about belonging to a group, not about document structure.

Sense 9 examples: "the written part of the exam" - clearly a document section.

Therefore, sense 9 (part%1:09:00::) is the best choice.

Wait, indexing: The candidates are numbered 1-12. I need to return the index number.

Candidate 9 corresponds to sense_key=part%1:09:00::

So the answer should be {"sense_index": 9}

Let me double-check if there's any other possibility.

Could it be sense 1? "component part" - the Summary of Product Characteristics is a component of the EPAR. Yes, but sense 9 is more specific to abstract divisions like document sections.

Could it be sense 8? "assets belonging to..." - no, not about ownership.

Could it be sense 4? "that which concerns a person..." - "on our part" - no.

Could it be sense 12? "the part played by a person..." - no.

Sense 9 is clearly the best fit.

One final check: The phrase is "also part of the EPAR". The Summary of Product Characteristics is a document that is included as a section/part of the larger EPAR document. This fits the pattern of "the finance section of the company" or "the written part of the exam".

Yes, sense 9.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
7. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
13. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 The user wants me to perform Word Sense Disambiguation for the word "active" in the given context.

 Context analysis:
 The sentence is: "The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine..."
 Later it mentions: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes..."

 Here, "active substance" refers to the ingredient that is actually producing the biological effect. It's the component that exerts influence or produces a change (therapeutic effect).

 Looking at the candidate senses:

 1. active%3:00:02:: - tending to become more severe or wider in scope (e.g., active tuberculosis) - doesn't fit.
 2. active%5:00:00:operational:00 - military/naval operations - doesn't fit.
 3. active%3:00:03:: - disposed to take action or effectuate change - possible, but more about disposition/personality.
 4. active%5:00:00:involved:00 - taking part in an activity - possible, but not quite right for chemical substances.
 5. active%3:00:01:: - characterized by energetic activity - physical energy, not right.
 6. active%3:00:07:: - exerting influence or producing a change or effect - examples: "an active ingredient" - THIS MATCHES PERFECTLY.
 7. active%3:00:06:: - full of activity or engaged in continuous activity - markets, seaports - not right.
 8. active%5:00:00:existent:00 - in operation - possible but less specific than 6.
 9. active%3:00:10:: - sun activity - no.
 10. active%3:00:09:: - grammatical subject as actor - no.
 11. active%3:00:00:: - verbs expressing action - no.
 12. active%3:00:05:: - volcanos capable of erupting - no.
 13. active%3:00:04:: - volcanos erupting - no.
 14. active%3:00:08:: - engaged in full-time work - no.

 Sense 6 (active%3:00:07::) is defined as "exerting influence or producing a change or effect" with the example "an active ingredient". This is exactly the pharmaceutical context of "active substance" meaning the substance that is pharmacologically active/producing the therapeutic effect.

 The index appears to be 6 based on the ordering (though WordNet sense keys are not just indices, the user wants the "sense_index"). Looking at the list:
 1. sense_key=active%3:00:02::
 2. sense_key=active%5:00:00:operational:00
 3. sense_key=active%3:00:03::
 4. sense_key=active%5:00:00:involved:00
 5. sense_key=active%3:00:01::
 6. sense_key=active%3:00:07::
 7. sense_key=active%3:00:06::
 8. sense_key=active%5:00:00:existent:00
 9. sense_key=active%3:00:10::
 10. sense_key=active%3:00:09::
 11. sense_key=active%3:00:00::
 12. sense_key=active%3:00:05::
 13. sense_key=active%3:00:04::
 14. sense_key=active%3:00:08::

 So sense_key=active%3:00:07:: is at position/index 6.

 Wait, let me double-check the ordering. The user lists:
 1. sense_key=active%3:00:02::
 2. sense_key=active%5:00:00:operational:00
 3. sense_key=active%3:00:03::
 4. sense_key=active%5:00:00:involved:00
 5. sense_key=active%3:00:01::
 6. sense_key=active%3:00:07::
 ...

 Yes, it's the 6th one in the list.

 The definition "exerting influence or producing a change or effect" with example "an active ingredient" perfectly matches "active substance" in the context of pharmaceuticals (referring to pemetrexed as the active substance in Alimta).

 Therefore, the answer should be {"sense_index": 6}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: substance
Target surface form: substance
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=substance%1:03:00:: | definition=the real physical matter of which a person or thing consists | examples=DNA is the substance of our genes
2. sense_key=substance%1:09:01:: | definition=the choicest or most essential or most vital part of some idea or experience | synonyms=kernel, core, center, centre, essence, gist | examples=the gist of the prosecutor's argument; the heart and soul of the Republican Party
3. sense_key=substance%1:09:00:: | definition=the idea that is intended | synonyms=meaning | examples=What is the meaning of this proverb?
4. sense_key=substance%1:27:00:: | definition=material of a particular kind or constitution | examples=the immune response recognizes invading substances
5. sense_key=substance%1:21:00:: | definition=considerable capital (wealth or income) | synonyms=means | examples=he is a man of means
6. sense_key=substance%1:10:00:: | definition=what a communication that is about something is about | synonyms=message, content, subject matter
7. sense_key=substance%1:03:01:: | definition=a particular kind or species of matter with uniform properties | examples=shigella is one of the most toxic substances known to man

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the word "substance" in the given context.

 Context analysis:
 - The text is about a medicine called Alimta
 - It mentions "The active substance in Alimta, pemetrexed..."
 - Pemetrexed is described as a cytotoxic medicine/antimetabolite
 - It's a chemical compound that gets converted in the body to block enzymes
 - This is clearly referring to the chemical/matter that constitutes the medicine

 Looking at the candidate senses:

 1. sense_key=substance%1:03:00:: | definition=the real physical matter of which a person or thing consists | examples=DNA is the substance of our genes
 - This refers to physical matter. The "active substance" here is pemetrexed, which is indeed the physical chemical matter that makes up the drug.

 2. sense_key=substance%1:09:01:: | definition=the choicest or most essential or most vital part of some idea or experience | synonyms=kernel, core, center, centre, essence, gist
 - This is about abstract ideas/essence, not physical chemical compounds.

 3. sense_key=substance%1:09:00:: | definition=the idea that is intended | synonyms=meaning
 - Abstract meaning, not relevant here.

 4. sense_key=substance%1:27:00:: | definition=material of a particular kind or constitution | examples=the immune response recognizes invading substances
 - This is about materials/constitution. Could fit, but let's look at others.

 5. sense_key=substance%1:21:00:: | definition=considerable capital (wealth or income) | synonyms=means
 - Financial meaning, clearly not relevant.

 6. sense_key=substance%1:10:00:: | definition=what a communication that is about something is about | synonyms=message, content, subject matter
 - About communication/content, not relevant.

 7. sense_key=substance%1:03:01:: | definition=a particular kind or species of matter with uniform properties | examples=shigella is one of the most toxic substances known to man
 - This refers to a specific kind of matter with uniform properties. The example mentions "toxic substances" which are chemical substances.

 Comparing sense 1 and sense 7:
 - Sense 1: "the real physical matter of which a person or thing consists" - This is about the constituent matter of something.
 - Sense 7: "a particular kind or species of matter with uniform properties" - This is about specific types/kinds of matter.

 In the context "The active substance in Alimta, pemetrexed...", we are referring to pemetrexed as the specific chemical compound (a particular kind of matter with uniform properties) that is the active ingredient.

 However, sense 1 could also fit: "the real physical matter of which a person or thing consists" - pemetrexed is the physical matter of which the medicine consists.

 But looking at the examples:
 - Sense 1 example: "DNA is the substance of our genes" - DNA is the material making up genes.
 - Sense 7 example: "shigella is one of the most toxic substances known to man" - Shigella (bacteria/toxin) is a specific substance.

 In pharmaceutical contexts, "active substance" typically refers to the specific chemical compound (active ingredient) that has the therapeutic effect. This aligns well with sense 7: "a particular kind or species of matter with uniform properties."

 Sense 4: "material of a particular kind or constitution" - example "the immune response recognizes invading substances" - this is also plausible.

 But sense 7 seems most specific to chemical/pharmaceutical substances. The phrase "active substance" in medical/pharmaceutical English typically maps to sense 7 (a specific chemical entity).

 Let me check WordNet structure mentally:
 - substance%1:03:00:: is usually the general "physical matter" sense
 - substance%1:03:01:: is usually the "chemical substance" sense (specific kind of matter)

 In the context, "pemetrexed" is identified as the active substance. Pemetrexed is a specific chemical compound. Therefore, sense 7 (substance%1:03:01::) is the best fit.

 Wait, looking at the indices provided:
 1. substance%1:03:00::
 2. substance%1:09:01::
 3. substance%1:09:00::
 4. substance%1:27:00::
 5. substance%1:21:00::
 6. substance%1:10:00::
 7. substance%1:03:01::

 So sense 7 is substance%1:03:01:: - "a particular kind or species of matter with uniform properties"

 This is the correct sense for "active substance" referring to a pharmaceutical ingredient.

 Actually, looking at sense 4: substance%1:27:00:: - "material of a particular kind or constitution" - this could also work, but 1:27 is usually for "substance" as in "substance abuse" or foreign substances in the body? No, looking at the example "the immune response recognizes invading substances" - this is about foreign materials entering the body.

 But sense 7 with the example "shigella is one of the most toxic substances known to man" is clearly about chemical/biological substances, which matches "pemetrexed" as a chemical drug substance.

 Therefore, the best sense is index 7.

 Wait, I need to be careful. The user asks for the "single best indexed sense" and the format is {"sense_index": 3} where the number corresponds to the position in the list (1-7).

 So if I choose sense 7, I should return {"sense_index": 7}.

 Let me double-check sense 1 vs sense 7:
 - Sense 1: "the real physical matter of which a person or thing consists" - This is the stuff something is made of. Example: "DNA is the substance of our genes."
 - Sense 7: "a particular kind or species of matter with uniform properties" - This is a specific type of matter. Example: "shigella is one of the most toxic substances known to man."

 In "the active substance in Alimta", we are identifying pemetrexed as the specific chemical compound that is active. This is not saying "pemetrexed is the substance (physical matter) of Alimta" in the sense of constitution (like DNA is the substance of genes), but rather "pemetrexed is the active substance" meaning it is the active chemical ingredient/species of matter.

 In pharmaceutical terminology, an "active substance" is a specific chemical entity (sense 7), not just the generic physical matter (sense 1).

 Also, sense 4: "material of a particular kind or constitution" - this is close but the example suggests it's about substances recognized by the immune system, which could be proteins, pathogens, etc. But sense 7 is more specifically about chemical substances with uniform properties.

 I think sense 7 is the best choice.

 Actually, looking at WordNet 3.0 or 3.1:
 - 1:03:00 is "the real physical matter of which a person or thing consists"
 - 1:03:01 is "a particular kind or species of matter with uniform properties" (e.g., "shigella is one of the most toxic substances known to man")

 Yes, for a drug like pemetrexed, it is a particular kind of matter (chemical compound) with uniform properties. So sense 7.

 But let me reconsider sense 4: substance%1:27:00:: - "material of a particular kind or constitution"
 This could also fit "active substance" as a material of a particular kind.

 However, the distinction in WordNet is:
 - 1:03:01 is specifically for chemical substances (toxic substances, chemical substances)
 - 1:27:00 is more general material constitution

 The example for 1:27:00 is "the immune response recognizes invading substances" - this is about foreign substances entering the body, which could be proteins, bacteria, chemicals, etc.

 But 1:03:01 is specifically about kinds of matter with uniform properties - chemical substances.

 Given that pemetrexed is a chemical compound (antimetabolite), sense 7 (1:03:01) is most appropriate.

 Final check: The user wants the JSON format {"sense_index": 7}.

provider: ModelRun


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 The user wants me to perform Word Sense Disambiguation for the word "medicine" in the given context.

 Let me analyze the context:
 - The text is about Alimta, a drug used for cancer treatment
 - It mentions "anti-emetic medicine (to prevent vomiting)"
 - It mentions "cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells)"
 - The target word "medicine" here refers to a substance/drug that treats disease (specifically cancer)

 Now let's look at the candidate senses:

 1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
    - This refers to the field of study or branch of science, not a specific drug/substance.

 2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
    - This refers to a substance/drug used to treat disease. This matches the context where "medicine" refers to Alimta/pemetrexed as a cytotoxic substance that kills cancer cells.

 3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
    - This refers to the profession or practice of being a doctor, not a substance.

 4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine
    - This is a figurative usage meaning punishment, clearly not the intended meaning in this medical context.

 The context clearly describes "medicine" as a substance (pemetrexed) that treats disease (cancer). It is described as "cytotoxic" and belonging to "antimetabolites", and it "kills cells". This is clearly referring to a pharmaceutical substance/drug.

 Therefore, sense 2 is the correct choice: "something that treats or prevents or alleviates the symptoms of disease" (medication, medicament, medicinal drug).

 The answer should be: {"sense_index": 2}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 The user wants me to perform Word Sense Disambiguation for the target word "medicine" in the given context.

 Let me analyze the context:
 - The text is about a drug called Alimta (pemetrexed)
 - It mentions "an anti-emetic medicine (to prevent vomiting)"
 - It mentions "a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells)"

 So the target word "medicine" is referring to a substance/drug used to treat or prevent disease, not the field of study, the profession, or punishment.

 Now let's look at the candidate senses:

 1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
 - This refers to the field/science of medicine (e.g., "he specializes in internal medicine"). Not what we want here.

 2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
 - This refers to a substance/drug used for treatment. The context explicitly talks about "anti-emetic medicine" and "cytotoxic medicine" as substances given to patients. This matches perfectly.

 3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
 - This refers to the profession or practice (e.g., "he studied medicine"). The context is talking about specific drugs, not the profession.

 4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine
 - This is the figurative sense ("take your medicine" meaning accept punishment). Clearly not relevant here.

 The context clearly uses "medicine" to mean a substance used for treatment - specifically referring to anti-emetic medicine and cytotoxic medicine as pharmaceutical substances. This aligns with sense 2.

 Wait, I need to check the indexing. The user wants the "indexed sense" - looking at the list, they are numbered 1, 2, 3, 4. So I should return the number 2.

 Actually, looking carefully: "Choose the single best indexed sense". The candidates are labeled 1, 2, 3, 4. So the answer should be sense_index 2.

 But let me double-check the WordNet sense keys to make sure I understand the indexing correctly:
 - medicine%1:09:00:: is sense 1
 - medicine%1:06:00:: is sense 2
 - medicine%1:04:00:: is sense 3
 - medicine%1:04:02:: is sense 4 (note the 02 at the end)

 Yes, the numbering corresponds to the list order.

 So the answer is {"sense_index": 2}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: kill
Target surface form: kills
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=kill%2:35:00:: | definition=cause to die; put to death, usually intentionally or knowingly | examples=This man killed several people when he tried to rob a bank; The farmer killed a pig for the holidays
2. sense_key=kill%2:41:01:: | definition=thwart the passage of | synonyms=shoot down, defeat, vote down, vote out | examples=kill a motion; he shot down the student's proposal
3. sense_key=kill%2:30:08:: | definition=end or extinguish by forceful means | synonyms=stamp out | examples=Stamp out poverty!
4. sense_key=kill%2:42:00:: | definition=be fatal | examples=cigarettes kill; drunken driving kills
5. sense_key=kill%2:39:00:: | definition=be the source of great pain for | examples=These new shoes are killing me!
6. sense_key=kill%2:37:00:: | definition=overwhelm with hilarity, pleasure, or admiration | examples=The comedian was so funny, he was killing me!
7. sense_key=kill%2:35:06:: | definition=hit with so much force as to make a return impossible, in racket games | examples=She killed the ball
8. sense_key=kill%2:35:05:: | definition=hit with great force | examples=He killed the ball
9. sense_key=kill%2:35:02:: | definition=deprive of life | examples=AIDS has killed thousands in Africa
10. sense_key=kill%2:35:01:: | definition=cause the death of, without intention | examples=She was killed in the collision of three cars
11. sense_key=kill%2:34:00:: | definition=drink down entirely | synonyms=toss off, pop, bolt down, belt down, pour down, down | examples=He downed three martinis before dinner; She killed a bottle of brandy that night
12. sense_key=kill%2:30:00:: | definition=mark for deletion, rub off, or erase | synonyms=obliterate, wipe out | examples=kill these lines in the President's speech
13. sense_key=kill%2:30:04:: | definition=tire out completely | examples=The daily stress of her work is killing her
14. sense_key=kill%2:30:03:: | definition=cause to cease operating | examples=kill the engine
15. sense_key=kill%2:30:02:: | definition=destroy a vitally essential quality of or in | examples=Eating artichokes kills the taste of all other foods

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
 The user wants me to perform Word Sense Disambiguation for the word "kills" in the given context.

 Context analysis:
 - The text is about a medicine called Alimta (pemetrexed)
 - It's described as a "cytotoxic medicine"
 - The specific phrase is: "a medicine that kills cells that are dividing, such as cancer cells"
 - This is describing the mechanism of action of a chemotherapy drug
 - The drug causes cell death, specifically in dividing cells (cancer cells)

 Looking at the candidate senses:

 1. sense_key=kill%2:35:00:: | definition=cause to die; put to death, usually intentionally or knowingly | examples=This man killed several people when he tried to rob a bank; The farmer killed a pig for the holidays
 - This is about causing death, usually intentionally. While cells are being caused to die, this sense seems more focused on human/animal death with intention.

 2. sense_key=kill%2:41:01:: | definition=thwart the passage of | synonyms=shoot down, defeat, vote down, vote out | examples=kill a motion; he shot down the student's proposal
 - This is about stopping legislation/proposals. Not relevant.

 3. sense_key=kill%2:30:08:: | definition=end or extinguish by forceful means | synonyms=stamp out | examples=Stamp out poverty!
 - This is metaphorical ending of abstract things. Not quite right for biological cell death.

 4. sense_key=kill%2:42:00:: | definition=be fatal | examples=cigarettes kill; drunken driving kills
 - This is intransitive - "cigarettes kill" (cause death). The target is transitive "kills cells".

 5. sense_key=kill%2:39:00:: | definition=be the source of great pain for | examples=These new shoes are killing me!
 - Slang/figurative use. Not relevant.

 6. sense_key=kill%2:37:00:: | definition=overwhelm with hilarity, pleasure, or admiration | examples=The comedian was so funny, he was killing me!
 - Figurative use. Not relevant.

 7. sense_key=kill%2:35:06:: | definition=hit with so much force as to make a return impossible, in racket games | examples=She killed the ball
 - Sports term. Not relevant.

 8. sense_key=kill%2:35:05:: | definition=hit with great force | examples=He killed the ball
 - Sports/physical impact. Not relevant.

 9. sense_key=kill%2:35:02:: | definition=deprive of life | examples=AIDS has killed thousands in Africa
 - This is about causing death, depriving of life. This could work for cells.

 10. sense_key=kill%2:35:01:: | definition=cause the death of, without intention | examples=She was killed in the collision of three cars
 - Accidental causing of death. The medicine is intentionally designed to kill cancer cells, so this might not fit perfectly, though the mechanism is biological.

 11. sense_key=kill%2:34:00:: | definition=drink down entirely | synonyms=toss off, pop, bolt down, belt down, pour down, down | examples=He downed three martinis before dinner; She killed a bottle of brandy that night
 - Drinking. Not relevant.

 12. sense_key=kill%2:30:00:: | definition=mark for deletion, rub off, or erase | synonyms=obliterate, wipe out | examples=kill these lines in the President's speech
 - Editing/deleting text. Not relevant.

 13. sense_key=kill%2:30:04:: | definition=tire out completely | examples=The daily stress of her work is killing her
 - Exhaustion. Not relevant.

 14. sense_key=kill%2:30:03:: | definition=cause to cease operating | examples=kill the engine
 - Stopping machines. Cells aren't machines in this sense, though metaphorically similar.

 15. sense_key=kill%2:30:02:: | definition=destroy a vitally essential quality of or in | examples=Eating artichokes kills the taste of all other foods
 - Destroying qualities. Not quite right.

 Now comparing sense 1 and sense 9:
 - Sense 1: "cause to die; put to death, usually intentionally or knowingly" - examples involve humans/animals
 - Sense 9: "deprive of life" - example "AIDS has killed thousands in Africa"

 Both could potentially apply to cells. However, in biomedical contexts, when we say a drug "kills cells," we are typically using the biological sense of causing cell death.

 Looking at the WordNet hierarchy:
 - Sense 1 (kill%2:35:00) is the general "cause to die" sense
 - Sense 9 (kill%2:35:02) is "deprive of life"
 - Sense 10 (kill%2:35:01) is "cause the death of, without intention"

 Actually, looking carefully at the sense keys:
 - kill%2:35:00 is the first sense (index 1 in the list)
 - kill%2:35:02 is sense 9 in the list
 - kill%2:35:01 is sense 10 in the list

 In WordNet, the sense numbering usually goes from most common to least common, but here the user has provided an indexed list 1-15.

 The context is clearly about a cytotoxic drug causing cell death. This is a literal killing (causing death) of cells.

 Between sense 1 (cause to die; put to death, usually intentionally or knowingly) and sense 9 (deprive of life):
 - Sense 1 emphasizes intentionality and is often used for deliberate killing (murder, execution)
 - Sense 9 is more general "deprive of life"
 - However, sense 1's examples include "The farmer killed a pig for the holidays" which is intentional but also biological.

 But wait, looking at sense 9's example: "AIDS has killed thousands in Africa" - this is about disease causing death, which is more analogous to a drug causing cell death.

 However, sense 1 is the primary sense of "kill" - to cause to die. The "intentionally or knowingly" part is typical but not exclusive.

 Actually, looking at the biomedical context, "kill cells" is standard terminology for cytotoxicity. This would map to the general "cause to die" sense.

 But I need to check if there's a specific sense for biological killing. Looking at the list, sense 9 "deprive of life" seems to be the biological/medical sense based on the AIDS example.

 However, sense 1 is also valid. Let me think about the distinction:
 - Sense 1: "cause to die; put to death, usually intentionally or knowingly" - this is the agentive sense where someone/something causes death
 - Sense 9: "deprive of life" - this is also causative but perhaps more focused on the biological aspect

 Actually, looking at WordNet structure online or from knowledge:
 - kill%2:35:00:: is the main transitive sense
 - kill%2:35:02:: is "deprive of life"

 In the context of "a medicine that kills cells", the medicine is the agent causing the cells to die. This is a straightforward instance of "cause to die" (sense 1) or "deprive of life" (sense 9).

 But sense 9's example "AIDS has killed thousands" suggests it's used for pathogens/diseases causing death. A medicine causing cell death is similar - it's an agent causing biological death.

 However, sense 1 is broader and includes "The farmer killed a pig" which is also biological death.

 Let me reconsider the intentionality aspect. The medicine is designed specifically to kill cancer cells (intentionally). So sense 1 fits well with "usually intentionally or knowingly".

 But sense 10 is "cause the death of, without intention" which would be accidental.

 Given that:
 1. The drug is intentionally designed to kill cells (cytotoxic)
 2. The context is medical/scientific
 3. Sense 1 is the primary sense of causing death

 I think sense 1 is the best fit. However, sense 9 is also strong.

 Wait, looking at the user's list order, these seem to be arbitrary indices 1-15, not the WordNet sense numbers. The sense keys are provided.

 The sense keys are:
 1. kill%2:35:00::
 9. kill%2:35:02::
 10. kill%2:35:01::

 In WordNet:
 - kill%2:35:00 is "cause to die; put to death, usually intentionally or knowingly"
 - kill%2:35:01 is "cause the death of, without intention"
 - kill%2:35:02 is "deprive of life"

 Actually, checking WordNet:
 - kill.v.01: cause to die; put to death, usually intentionally or knowingly
 - kill.v.02: thwart the passage of
 - kill.v.03: end or extinguish by forceful means
 - kill.v.04: be fatal
 - kill.v.05: be the source of great pain for
 - kill.v.06: overwhelm with hilarity, pleasure, or admiration
 - kill.v.07: hit with so much force as to make a return impossible, in racket games
 - kill.v.08: hit with great force
 - kill.v.09: deprive of life
 - kill.v.10: cause the death of, without intention
 - kill.v.11: drink down entirely
 - kill.v.12: mark for deletion, rub off, or erase
 - kill.v.13: tire out completely
 - kill.v.14: cause to cease operating
 - kill.v.15: destroy a vitally essential quality of or in

 So in the user's list:
 - Index 1 corresponds to kill.v.01 (sense_key=kill%2:35:00)
 - Index 9 corresponds to kill.v.09 (sense_key=kill%2:35:02)
 - Index 10 corresponds to kill.v.10 (sense_key=kill%2:35:01)

 Now, for "kills cells" in a medical context:
 - "Deprive of life" (sense 9/kill.v.09) is very close to "cause to die" (sense 1/kill.v.01)
 - The distinction in WordNet is subtle. Sense 1 often implies agency and intention (murder, execution, slaughter). Sense 9 is more general "deprive of life" and includes things like "AIDS has killed thousands".

 For a drug killing cells, both could work. However, "deprive of life" (sense 9) is often used in biological contexts where organisms or cells are deprived of life.

 But looking at the example for sense 1: "The farmer killed a pig for the holidays" - this is biological killing for a purpose.

 Looking at the example for sense 9: "AIDS has killed thousands in Africa" - this is a disease killing people.

 A drug is more like an agent (like a farmer) than a disease (like AIDS), though both cause biological death.

 However, in the specific context of cytotoxic drugs, the terminology is that the drug "kills" the cells - this is standard biological usage.

 I think sense 1 (cause to die) is the most appropriate because:
 1. It is the primary sense
 2. The drug is an agent causing the death of cells
 3. It is intentional (the drug is designed to do this)

 But sense 9 is also very plausible because:
 1. It specifically mentions AIDS killing people, which is biological
 2. "Deprive of life" is the biological definition

 Let me check if there's any other sense that could fit. Sense 15 "destroy a vitally essential quality of or in" - no, that's about taste. Sense 14 "cause to cease operating" - could be metaphorical for cells, but "kill" in biology is literal death, not just stopping operation.

 Between 1 and 9, I think 1 is slightly better because the context emphasizes the medicine as an agent acting on cells ("a medicine that kills cells"), which aligns with "cause to die; put to death" (sense 1) rather than just "deprive of life" (sense 9). The intentionality aspect also fits because the medicine is specifically designed to kill cancer cells.

 However, looking at the example for sense 9 again: "AIDS has killed thousands in Africa" - AIDS is a condition/disease, not an intentional agent. The drug is an intentional agent.

 Therefore, sense 1 is the best fit.

 Wait, I should reconsider sense 9. In WordNet, sense 9 (kill%2:35:02) "deprive of life" might be the hypernym or a more general sense. But given the example of AIDS, it seems to be for pathogens or biological agents.

 Actually, looking at the definitions again:
 - Sense 1: "cause to die; put to death, usually intentionally or knowingly"
 - Sense 9: "deprive of life"

 The key difference is "intentionally or knowingly". While the drug is intentionally administered to kill cells, the cells themselves are not "put to death" in the legal/moral sense, but rather their biological life is terminated.

 But in biomedical English, "kill" is used transitively for cells in the sense of causing cell death. This maps to the general "cause to die" sense.

 I think I'm overthinking. The most common sense of "kill" when applied to cells in a medical context is sense 1 or sense 9. Given that sense 1 is the first and primary sense, and the examples include killing animals (biological), it is likely the correct choice.

 However, looking at the user's instruction: "WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense."

 The context: "a medicine that kills cells that are dividing"
 - This is about causing the death of cells
 - It is biological
 - It is the intended effect

 Sense 1 examples: "This man killed several people", "The farmer killed a pig"
 Sense 9 examples: "AIDS has killed thousands"

 The medicine is like the farmer (agent) killing the pig (cells), not like AIDS killing people. So sense 1.

 But wait, cells are not sentient beings, so "put to death" might seem odd, but "cause to die" is perfect.

 I will go with sense 1.

 Actually, one more check: is there any chance it's sense 15 "destroy a vitally essential quality of or in"? No, that's clearly wrong.

 Sense 14 "cause to cease operating"? Cells don't "operate" like engines.

 So it's between 1, 9, and 10.
 - 10 is without intention (accident), so wrong.
 - 9 is "deprive of life" with AIDS example (pathogen)
 - 1 is "cause to die" with farmer example (agent)

 The medicine is an agent, so 1.

 Final decision: sense_index 1