[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: have
Target surface form: have
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who <t>have</t> certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=have%2:40:00:: | definition=have or possess, either in a concrete or an abstract sense | synonyms=have got, hold | examples=She has $1,000 in the bank; He has got two beautiful daughters
2. sense_key=have%2:42:00:: | definition=have as a feature | synonyms=feature | examples=This restaurant features the most famous chefs in France
3. sense_key=have%2:39:06:: | definition=go through (mental or physical states or experiences) | synonyms=experience, receive, get | examples=get an idea; experience vertigo
4. sense_key=have%2:40:04:: | definition=have ownership or possession of | synonyms=own, possess | examples=He owns three houses in Florida; How many cars does she have?
5. sense_key=have%2:30:00:: | definition=cause to move; cause to be in a certain position or condition | synonyms=get, let | examples=He got his squad on the ball; This let me in for a big surprise
6. sense_key=have%2:34:00:: | definition=serve oneself to, or consume regularly | synonyms=consume, ingest, take in, take | examples=Have another bowl of chicken soup!; I don't take sugar in my coffee
7. sense_key=have%2:41:00:: | definition=have a personal or business relationship with someone | examples=have a postdoc; have an assistant
8. sense_key=have%2:36:00:: | definition=organize or be responsible for | synonyms=hold, throw, make, give | examples=hold a reception; have, throw, or make a party
9. sense_key=have%2:40:01:: | definition=have left | examples=I have two years left; I don't have any money left
10. sense_key=have%2:42:12:: | definition=be confronted with | examples=What do we have here?; Now we have a fine mess
11. sense_key=have%2:30:01:: | definition=undergo | synonyms=experience | examples=The stocks had a fast run-up
12. sense_key=have%2:29:02:: | definition=suffer from; be ill with | examples=She has arthritis
13. sense_key=have%2:32:00:: | definition=cause to do; cause to act in a specified manner | synonyms=induce, stimulate, cause, get, make | examples=The ads induced me to buy a VCR; My children finally got me to buy a computer
14. sense_key=have%2:40:05:: | definition=receive willingly something given or offered | synonyms=accept, take | examples=The only girl who would have him was the miller's daughter; I won't have this dog in my house!
15. sense_key=have%2:40:03:: | definition=get something; come into possession of | synonyms=receive | examples=receive payment; receive a gift
16. sense_key=have%2:29:05:: | definition=undergo (as of injuries and illnesses) | synonyms=suffer, sustain, get | examples=She suffered a fracture in the accident; He had an insulin shock after eating three candy bars
17. sense_key=have%2:40:02:: | definition=achieve a point or goal | synonyms=get, make | examples=Nicklaus had a 70; The Brazilian team got 4 goals
18. sense_key=have%2:29:00:: | definition=cause to be born | synonyms=give birth, deliver, bear, birth | examples=My wife had twins yesterday!
19. sense_key=have%2:35:00:: | definition=have sex with; archaic use | synonyms=take | examples=He had taken this woman when she was most vulnerable

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the context:**
    *   Sentence: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who <t>have</t> certain other side effects."
    *   Target word: "have"
    *   Subject: "patients" (or relative pronoun "who" referring to patients).
    *   Object: "certain other side effects".
    *   Meaning: The patients are experiencing or suffering from side effects. Side effects are negative medical conditions or symptoms resulting from treatment.

2.  **Evaluate candidate senses:**

    *   *Sense 1 (have%2:40:00::):* "have or possess...". Examples: "She has $1,000". Possession doesn't fit side effects well. You don't "possess" a side effect like an object.
    *   *Sense 2 (have%2:42:00::):* "have as a feature". Examples: "This restaurant features...". Usually applies to objects or places having characteristics. Not people having side effects.
    *   *Sense 3 (have%2:39:06::):* "go through (mental or physical states or experiences)". Examples: "get an idea", "experience vertigo". This is a strong candidate. Patients *experience* side effects.
    *   *Sense 4 (have%2:40:04::):* "have ownership or possession of". Examples: "He owns three houses". Similar to Sense 1, inappropriate for side effects.
    *   *Sense 5 (have%2:30:00::):* "cause to move...". Irrelevant.
    *   *Sense 6 (have%2:34:00::):* "serve oneself to, or consume regularly". Irrelevant.
    *   *Sense 7 (have%2:41:00::):* "have a personal or business relationship with someone". Irrelevant.
    *   *Sense 8 (have%2:36:00::):* "organize or be responsible for". Irrelevant.
    *   *Sense 9 (have%2:40:01::):* "have left". Irrelevant.
    *   *Sense 10 (have%2:42:12::):* "be confronted with". Examples: "What do we have here?". Not quite right for medical side effects.
    *   *Sense 11 (have%2:30:01::):* "undergo". Examples: "The stocks had a fast run-up". This is a synonym for experience.
    *   *Sense 12 (have%2:29:02::):* "suffer from; be ill with". Examples: "She has arthritis". This is very close. Side effects are essentially forms of illness or adverse medical conditions caused by the drug.
    *   *Sense 13 (have%2:32:00::):* "cause to do...". Irrelevant.
    *   *Sense 14 (have%2:40:05::):* "receive willingly...". Irrelevant.
    *   *Sense 15 (have%2:40:03::):* "get something; come into possession of". Irrelevant.
    *   *Sense 16 (have%2:29:05::):* "undergo (as of injuries and illnesses)". Examples: "She suffered a fracture", "He had an insulin shock". This is also very close. "Side effects" fall under the umbrella of injuries/illnesses/negative medical events experienced during treatment.
    *   *Sense 17 (have%2:40:02::):* "achieve a point or goal". Irrelevant.
    *   *Sense 18 (have%2:29:00::):* "cause to be born". Irrelevant.
    *   *Sense 19 (have%2:35:00::):* "have sex with". Irrelevant.

3.  **Refine choice:**
    The competition is mainly between:
    *   Sense 3: "go through... experiences"
    *   Sense 12: "suffer from; be ill with"
    *   Sense 16: "undergo (as of injuries and illnesses)"

    Let's look at the definitions and examples carefully.
    *   Context: "patients... who have certain other side effects."
    *   "Side effects" are adverse reactions, akin to illnesses or symptoms.
    *   Sense 12: "suffer from; be ill with". Example: "She has arthritis". This fits well. Patients "have" side effects much like they "have" arthritis or a cold.
    *   Sense 16: "undergo (as of injuries and illnesses)". Example: "He had an insulin shock". This also fits well. It emphasizes the event/experience of the specific medical incident.
    *   Sense 3: "go through (mental or physical states or experiences)". Example: "experience vertigo". Vertigo is a side effect or symptom. This fits too.

    Which is most specific and appropriate?
    Sense 3 is broader ("experience"). One can "have a nice day" (experience).
    Sense 12 focuses on the state of being ill ("She has arthritis"). Side effects are often states (nausea, fatigue) but can be events.
    Sense 16 focuses on undergoing injuries/illnesses ("He had an insulin shock", "suffered a fracture").

    In medical contexts, "have a side effect" is often synonymous with "experience a side effect" (Sense 3) or "suffer from an illness/condition" (Sense 12/16).

    Let's look at the WordNet hierarchy (implied by glosses).
    Sense 12 gloss: "suffer from; be ill with".
    Sense 16 gloss: "undergo (as of injuries and illnesses)".
    Sense 3 gloss: "go through (mental or physical states or experiences)".

    Often, WordNet distinguishes between having a chronic condition (Sense 12 - "She has arthritis") and undergoing a specific event/injury (Sense 16 - "suffered a fracture").

    "Side effects" covers a range: rashes, nausea, kidney problems.
    If a patient has a rash (a side effect), do they "have" it like arthritis (Sense 12) or undergo it like a fracture (Sense 16)?
    Usage: "He has a rash." -> Sense 12 seems apt.
    Usage: "He had a seizure." -> Sense 16 or 12.

    However, let's look at Sense 3 again. Synonyms: "experience".
    "Patients who experience side effects." This is standard medical phrasing.
    Sense 3 examples: "get an idea", "experience vertigo".
    Sense 16 examples: "suffered a fracture", "had an insulin shock".
    Sense 12 examples: "She has arthritis".

    "Side effects" are adverse reactions.
    "Patients ... have certain other side effects."
    This usage is closest to "suffering from" or "experiencing".

    Let's compare Sense 3 and Sense 12/16.
    Sense 3 is "go through... experiences".
    Sense 12 is "suffer from; be ill with".
    Sense 16 is "undergo (as of injuries...)".

    Sense 16's examples ("suffered a fracture", "had an insulin shock") refer to specific events or acute occurrences. "Side effects" can be acute events.
    Sense 12's example ("She has arthritis") implies a state/condition.
    Sense 3 covers states ("experience vertigo") and mental states.

    If I check standard WordSense Disambiguation mappings for "have" + [medical condition/symptom]:
    "I have a cold" -> usually mapped to Sense 12 (be ill with).
    "I have cancer" -> Sense 12.
    "I had a heart attack" -> often mapped to Sense 16 (undergo event/injury).
    "I have side effects" -> Side effects are the consequences of the treatment. They are conditions or symptoms.
    "Side effects" is plural and general. "Have side effects" usually means "suffer from side effects" or "experience side effects".

    Let's look at the gloss for Sense 16: "undergo (as of injuries and illnesses)".
    Let's look at the gloss for Sense 3: "go through (mental or physical states or experiences)".

    Sense 3 is defined as `go through (mental or physical states or experiences)`. Synonyms include `experience`.
    Sense 16 is defined as `undergo (as of injuries and illnesses)`. Synonyms include `suffer`.
    Sense 12 is defined as `suffer from; be ill with`.

    Side effects are defined as "a secondary, typically undesirable effect of a drug or medical treatment."
    Therefore, having a side effect is having an undesirable effect/illness/symptom.
    If I say "He has nausea", he is experiencing a state. (Sense 3 or 12).
    If I say "He has kidney failure", he has a condition. (Sense 12).
    If I say "He had a reaction", he underwent an event. (Sense 16).

    The phrase "have certain other side effects" is a general catch-all.
    However, Sense 3 ("go through... experiences") is very broad. Sense 16 ("undergo (as of injuries and illnesses)") is specific to the medical/injury domain in a way that parallels the context.

    Let's check the examples in the candidates again.
    Sense 12: "She has arthritis". Arthritis is a condition/disease. Side effects are often conditions/symptoms.
    Sense 16: "He had an insulin shock". Insulin shock is an adverse reaction/event. Side effects are adverse reactions.
    Sense 3: "experience vertigo". Vertigo is a symptom/side effect.

    There is significant overlap. Let's look at the nuances.
    Sense 16's examples "suffered a fracture", "had an insulin shock" describe specific events usually.
    Sense 12's example "She has arthritis" describes a chronic or existing condition.
    Sense 3's example "experience vertigo" describes a state.

    "Side effects" covers both (e.g., "vomiting" - event/state, "hair loss" - condition).
    However, "have side effects" acts very much like "have arthritis" (be afflicted with).
    But let's look at Sense 16 again. Synonyms: `suffer`. Examples: "suffered a fracture".
    "Have side effects" is synonymous with "suffer side effects".
    "Have a fracture" (Sense 16).

    Let's try to distinguish Sense 12 and 16.
    Sense 12: "be ill with". Focus on the state of illness.
    Sense 16: "undergo... injuries and illnesses". Focus on the undergoing of the event/instance.
    Usually, if you "have" a disease (arthritis), it's Sense 12.
    If you "have" a specific incident (shock, fracture), it's Sense 16.
    Side effects are generally treated as incidents or developments during treatment, or states of illness caused by treatment.

    However, in the context of clinical trials or drug descriptions (like this text), "patients who have side effects" implies the occurrence or experience of them.

    Let's look at Sense 3 vs Sense 16.
    Sense 3: "go through... experiences". Synonym: "experience".
    Sense 16: "undergo... injuries...". Synonyms: "suffer".

    In medical WSD tasks, "have" + [symptom/condition] is often Sense 12 (illness) or Sense 16 (injury/acute event).
    "Side effects" are unwanted medical conditions.
    Consider the phrase "have side effects".
    Dictionary definitions of "have" in this context: "to experience or suffer from (a symptom, illness, or injury)". This combines Sense 3 and 16/12.

    Let's look at the examples provided in the prompt for Sense 16: "He had an insulin shock". Insulin shock is a side effect of insulin overdose.
    The example for Sense 12: "She has arthritis".

    "Side effects" are structurally closer to "insulin shock" (adverse reactions) than "arthritis" (chronic disease), although side effects can be chronic. The text lists "abnormal blood counts", "kidney problems".
    "Kidney problems" -> Sense 12 (illness).
    "Abnormal blood counts" -> State.

    However, the collective phrase "have side effects" acts as a unit meaning "experience adverse reactions".
    "Suffer from" (Sense 12) is very strong for "have side effects".
    "Undergo" (Sense 16) is strong for specific events.

    Let's evaluate Sense 3 "go through (mental or physical states or experiences)".
    Synonym: "experience".
    "Patients ... who experience certain other side effects."
    This is a very natural paraphrase.
    Sense 3 example: "experience vertigo". Vertigo is a side effect.

    Let's evaluate Sense 16.
    Example: "He had an insulin shock".
    "Patients ... who suffer certain other side effects."
    Also natural.

    Let's evaluate Sense 12.
    Example: "She has arthritis".
    "Patients ... who are ill with certain other side effects." (Less natural).
    "Patients ... who suffer from certain other side effects." (Natural).

    There is a subtle distinction in WordNet between Sense 12 and 16.
    Sense 12 (`have%2:29:02::`) usually implies a persistent state of health ("She has arthritis", "He has the flu").
    Sense 16 (`have%2:29:05::`) implies undergoing an injury or illness event ("suffered a fracture", "had a shock").

    "Side effects" are typically conceptualized as events or occurrences in the timeline of treatment (like the insulin shock example).
    "Blood counts are abnormal" -> state.
    "Have side effects" -> The occurrence of the side effects.

    Wait, Sense 3 (`have%2:39:06::`) gloss: "go through (mental or physical states or experiences)".
    Synonyms: `experience`.
    Examples: `get an idea`, `experience vertigo`.
    Vertigo is a physical state/experience. Side effects are physical states/experiences.

    However, Sense 16 (`have%2:29:05::`) is specifically tagged for injuries and illnesses.
    Gloss: "undergo (as of injuries and illnesses)".
    Side effects are illnesses/conditions induced by drugs.

    Let's check the hierarchy in WordNet 3.0/3.1.
    Sense 16 is `undergo`.
    Sense 12 is `suffer` (or related).

    Often, "have" + [illness] is assigned to Sense 12 ("She has a cold").
    But if the illness is an event (heart attack), it might be Sense 16.
    Side effects can be both.

    Let's look at the definitions again.
    Sense 12: "suffer from; be ill with".
    Sense 16: "undergo (as of injuries and illnesses)".

    The word "undergo" in Sense 16 fits "treatment" well ("patients undergoing treatment"), but does it fit "having side effects"? "Undergo side effects"? Not idiomatic.
    "Suffer side effects"? Yes.
    "Experience side effects"? Yes.

    Let's look at Sense 3 again.
    Definition: "go through (mental or physical states or experiences)".
    "Experience" is the primary synonym.
    "Patients who experience side effects." This is the most standard medical phrasing.
    Example "experience vertigo".
    Vertigo is a side effect.
    Therefore Sense 3 is a very strong candidate.

    Let's check Sense 12 vs Sense 3.
    Sense 12 "suffer from; be ill with" implies a focus on the resulting state of being ill.
    Sense 3 "go through... experiences" implies the process of experiencing it.
    "Side effects" are things that happen to the patient.

    Let's consider Sense 16 again.
    Example "He had an insulin shock". This is very specific and acute.

    Let's consider Sense 3 again.
    Example "experience vertigo".

    Is there a distinction between "have a cold" (Sense 12) and "have vertigo" (Sense 3)?
    A cold is an illness entity. Vertigo is a state/sensation.
    Side effects cover both (Rash = condition, Nausea = state/sensation, Shock = event).

    However, the grouping of Sense 3 with "get an idea" makes it seem mental/general.
    But the gloss includes "physical states". Vertigo is physical.

    Let's look at Sense 16 synonyms: `suffer`, `sustain`, `get`.
    "Suffer side effects" is extremely common.
    "Sustain side effects"? No.

    Sense 12 synonyms: None listed in the prompt, but definition "suffer from".
    "Suffer from side effects". Common.

    Let's look at the Sense 3 synonyms: `experience`, `receive`, `get`.
    "Experience side effects". Most common/neutral.

    Let's look at Sense 11: `have%2:30:01::` | definition=undergo | synonyms=experience | examples=The stocks had a fast run-up.
    Wait, this is Sense 11 in the list provided.
    Sense 11 is "undergo".
    Sense 16 is also "undergo (as of injuries...)".
    Why are there two "undergo" senses?
    Sense 11 example: "stocks had a fast run-up". This is about things undergoing change.
    Sense 16 example: "suffered a fracture". This is about people undergoing injury.

    So for people/medical context, Sense 16 is the specific "undergo" sense.

    Now comparing Sense 3 ("experience") and Sense 16 ("undergo/suffer injury/illness").
    The object is "side effects".
    Side effects = illnesses/adverse conditions.
    Sense 16 specifies "injuries and illnesses".
    Sense 3 specifies "physical states".

    Usually, specific WordNet senses are preferred over general ones.
    Sense 16 is specific to "injuries and illnesses". Side effects are illnesses/conditions.
    The example "He had an insulin shock" is a perfect parallel to "He had a side effect" (as an event).
    Even though "side effects" is plural and covers symptoms, the categorization "illnesses" covers side effects.
    Sense 12 ("be ill with") is also specific.

    Let's decide between Sense 12 and Sense 16.
    Sense 12 example: "She has arthritis". (Chronic state).
    Sense 16 example: "He had an insulin shock". (Acute event).
    "Side effects" of chemotherapy.
    Chemotherapy side effects: Nausea, vomiting, hair loss, low blood counts.
    Some are acute (vomiting), some are states (low blood counts, hair loss).
    "Patients who have side effects".
    This phrasing suggests the occurrence of the side effects during the treatment course.

    If we look at the sense keys:
    Sense 12: `have%2:29:02::`
    Sense 16: `have%2:29:05::`
    These share the prefix `have%2:29:...`.
    WordNet 3.0 lexicographer file 29 is often "change" or "body"? No, let's check standard WordNet structure.
    2:29 corresponds to the verb 'suffer'.
    Sense 2:29:00 is "cause to be born" (Wait, Sense 18 in list).
    Sense 2:29:01 is "suffer from".

    Let's check the list indices provided in the prompt carefully.
    Sense 12: `have%2:29:02::` | definition=suffer from; be ill with.
    Sense 16: `have%2:29:05::` | definition=undergo (as of injuries and illnesses).

    Note the synonyms for Sense 16: `suffer`.
    Note the definition of Sense 12: `suffer from`.

    "Have side effects" allows both.
    But Sense 16's examples ("suffered a fracture", "insulin shock") are events that happen to the body.
    Sense 12's examples ("She has arthritis") is a condition possessed/held by the body.

    Side effects are not typically described as something you "possess" in the sense of arthritis (though you can say "I have a side effect"). They are things that happen/occur.
    "Patients who experience side effects".

    Sense 16 "undergo" fits the medical trial context (events occurring).
    Sense 12 "be ill with" fits if we view side effects as the disease state.

    However, let's look at Sense 3 again (`have%2:39:06::`).
    "go through (mental or physical states or experiences)".
    Synonyms: `experience`.
    This is the most robust translation for "have side effects" -> "experience side effects".
    Does WordNet map "have + illness" to Sense 3?
    The example "experience vertigo" is a physical state.
    Vertigo is a symptom/side effect.
    This suggests Sense 3 covers symptoms/states.

    Sense 16 covers "injuries and illnesses".
    Is a side effect an illness? Yes, an adverse drug reaction is an iatrogenic illness.
    Is a side effect an injury? Yes, sometimes (e.g. organ damage).

    Which sense is "better"?
    Sense 3 is very broad ("get an idea").
    Sense 16 is domain specific ("injuries and illnesses").
    Usually, the specific sense is preferred. Sense 16 specifically mentions "illnesses".
    Therefore Sense 16 seems better than Sense 3.

    Now Sense 16 vs Sense 12.
    Sense 16: undergo (events/instances).
    Sense 12: be ill with (states/conditions).
    "Side effects" can be both.
    However, the context mentions: "Treatment should be delayed ... in patients who have side effects."
    This implies the occurrence of the side effects.
    Also, Sense 16 includes `suffer` as a synonym. "Suffer side effects" is very idiomatic.
    Sense 12 uses `suffer from` in the definition. "Suffer from side effects" is also idiomatic.

    Let's look at the examples again.
    Sense 12: "She has arthritis." (She possesses this condition).
    Sense 16: "He had an insulin shock." (He underwent this event).

    "Side effects" in chemotherapy often involve acute reactions (shock, vomiting, fever) as well as sustained conditions.
    "Have side effects" is a summary of the adverse events.
    I lean towards Sense 16 because "insulin shock" is a direct parallel to an adverse drug event (side effect).
    Sense 12's "arthritis" is a disease, not an event.
    Side effects are events in the narrative of treatment.

    Let's check Sense 11 (`have%2:30:01::`).
    "undergo".
    Example: "stocks had a fast run-up".
    This is for abstract processes usually, or non-medical.

    So it's between Sense 3 and Sense 16.
    Sense 3 (Experience) vs Sense 16 (Suffer/Undergo injury/illness).
    Sense 16 is a hyponym of Sense 11 (undergo)? No, lexicographer files vary.

    Let's look at the specific wording "have certain other side effects".
    "Suffer side effects" (Sense 16 synonym).
    "Experience side effects" (Sense 3 synonym).

    If we look at Sense 3's definition: "go through (mental or physical states or experiences)".
    If we look at Sense 16's definition: "undergo (as of injuries and illnesses)".

    Side effects are "injuries and illnesses" caused by drugs.
    Specificity favors Sense 16.
    Example match ("insulin shock" vs "vertigo"):
    Vertigo is a symptom. Insulin shock is a condition/event.
    Side effects are conditions/events.

    Wait, "vertigo" is listed under Sense 3.
    Vertigo is a classic side effect.
    So Sense 3 covers side effects.

    Is there a reason to choose Sense 3 over 16?
    Sense 3 includes "mental or physical states".
    Sense 16 includes "injuries and illnesses".
    Many side effects are symptoms (nausea, pain) which are "states".
    Many are "illnesses" (hepatitis, neuropathy).

    However, Sense 16 includes "suffer".
    "To reduce side effects... patients should take..."
    "Patients... who have certain other side effects."

    Let's check a corpus or WSD dataset conventions.
    "have a headache" -> usually Sense 12 or 16?
    "have a heart attack" -> Sense 16.
    "have cancer" -> Sense 12.
    "have a side effect".
    Side effects are like headaches or heart attacks in that they are specific negative occurrences.

    Let's look at the examples in Sense 16 again.
    "She suffered a fracture" (Injury).
    "He had an insulin shock" (Illness/Event).

    Let's look at Sense 12.
    "She has arthritis" (Illness/State).

    "Have side effects" is plural. "Have arthritis" is singular condition.
    "Have side effects" means "Have [a list of adverse events]".
    This aligns more with the "suffer/undergo" aspect of Sense 16.
    "He had two heart attacks" -> Sense 16.
    "She has arthritis" -> Sense 12.

    The countability/plurality often shifts the sense from "possessing a condition" (Sense 12) to "undergoing events" (Sense 16/3).
    "She has arthritides" (rare).
    "He has headaches" (He experiences headaches). -> This feels like Sense 3 or 16.

    "Patients who have side effects." -> Patients who experience/suffer these events.
    Sense 16 seems the best fit due to the domain "injuries and illnesses" and the synonym "suffer".

    Let's reconsider Sense 3.
    "Go through... experiences".
    This is the hypernym of undergoing specific medical events in many ontologies.
    But WordNet separates them.
    Sense 16 is defined specifically for "injuries and illnesses".
    Since "side effects" are explicitly medical negative outcomes, Sense 16 is the specific sense.

    Let's check if "have" can be Sense 11 (undergo).
    Sense 11: "undergo". Example "The stocks had a fast run-up".
    This seems to be for non-human subjects or metaphorical usage.
    Sense 16: "undergo (as of injuries and illnesses)". Human subjects.
    So Sense 16 is the correct "undergo" for this context.

    Final check between Sense 3 and Sense 16.
    Context: "patients ... who have certain other side effects."
    Sense 3: "go through... experiences".
    Sense 16: "undergo (as of injuries and illnesses)".

    Is a side effect an "illness"? Yes.
    Is it an "experience"? Yes.
    Specificity principle: Choose the most specific sense applicable. Sense 16 is specific to "injuries and illnesses". Sense 3 applies to anything (ideas, vertigo, states).
    Therefore, Sense 16 is the best choice.

    Also, Sense 3 synonyms: experience, receive, get.
    Sense 16 synonyms: suffer, sustain, get.
    "Suffer side effects" is a strong collocate.
    "Receive side effects" (Sense 3) is not idiomatic. You receive the drug, not the side effect (metaphorically maybe, but medically 'experience' or 'suffer' is better). Sense 3 has 'receive' as a synonym.
    Sense 16 has 'suffer'.
    Therefore Sense 16 is better.

    One counter-argument: "experience" is a synonym for Sense 3. "Experience side effects" is very common.
    However, "suffer" is a synonym for Sense 16. "Suffer side effects" is also common.
    The definition of Sense 16 explicitly names "illnesses".
    The definition of Sense 3 names "physical states".
    Side effects (like anaphylactic shock or liver failure mentioned in broader contexts of Alimta) are serious medical events/illnesses.
    Thus Sense 16.

    Sense 16 is the choice.

provider: Baidu


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: certain
Target surface form: certain
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have <t>certain</t> other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=certain%5:00:00:definite:00 | definition=definite but not specified or identified | examples=set aside a certain sum each week; to a certain degree
2. sense_key=certain%3:00:02:: | definition=having or feeling no doubt or uncertainty; confident and assured | synonyms=sure | examples=felt certain of success; was sure (or certain) she had seen it
3. sense_key=certain%3:00:01:: | definition=established beyond doubt or question; definitely known | examples=what is certain is that every effect must have a cause; it is certain that they were on the bus
4. sense_key=certain%3:00:03:: | definition=certain to occur; destined or inevitable; ; ; - Benjamin Franklin | synonyms=sure | examples=he was certain to fail; his fate is certain
5. sense_key=certain%3:00:05:: | definition=established irrevocably | synonyms=sealed | examples=his fate is sealed
6. sense_key=certain%5:00:00:reliable:00 | definition=reliable in operation or effect | synonyms=sure | examples=a quick and certain remedy; a sure way to distinguish the two
7. sense_key=certain%5:00:00:careful:00 | definition=exercising or taking care great enough to bring assurance | synonyms=sure | examples=be certain to disconnect the iron when you are through; be sure to lock the doors

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output: sense_index": 1}

finish_reason: stop

content: sense_index": 1}

role: assistant

reasoning_content:
1.  **Analyze the target word and context:**
    *   Target word: "certain"
    *   Sentence: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects."
    *   Context meaning: The word "certain" is modifying "other side effects". It implies specific, particular side effects, but they aren't named in this specific sentence. It's a quantifier or determiner here the candidate senses:5:00:00:definite:00`
        *   Definition: "definite but not specified or identified"
        *   Examples: "set aside a certain sum each week", "to a certain degree"
        *   Analysis: This sense captures the meaning of "specific but unnamed". In the text, "certain other side effects" means specified/identified). This fits perfectly.

    *   **Sense 2:** `sense_key=certain%3:00:02::`
        *   Definition: "having or feeling no doubt or uncertainty; confident and assured"
        *   Examples: "felt certain of success"
        *   Analysis: This refers to a subjective mental state (certainty). The context is not about a doctor *feeling* certain. It's about a set of side effects. This does.

    *   **Sense 3:** `sense_key=certain%3:00:01::`
        *   Definition: "established beyond doubt or question; definitely known"
        *   Examples: "what is certain is that..."
        *   Analysis: This refers to facts or truths being established. While the side effects exist, "certain" here is not predicating the truth of the side effects (e.g., "it is certain that side effects occurred"). It is quantifying them (specific ones). This is not the best destined or inevitable"
        *   Examples: "he was certain to fail"
        *   Analysis: This refers to future probability/inevitability. The text does not mean "side effects that are inevitable". It means "specific/particular side effects". This does not fit.

    *   **Sense 5:** `sense_key=certain%3:00:05::`
        *   Definition: "established irrevocably"
        *   Examples: "his fate is sealed"
        *   Analysis: Similar to Sense 4, deals with destiny or finality. Irrelevant to "certain side effects".

    *   **Sense 6:** `sense_key=certain%5:00:00:reliable:00`
        *   Definition: "reliable in operation or effect"
        *   Examples: "a certain remedy"
        *   Analysis: This is an adjective describing a noun's reliability. "Certain side effects" does not mean "reliable side effects". It means "specific side effects".

    *   **Sense 7:** `sense_key=certain%5:00:00:careful:00`
        *   Definition: "exercising or taking care..."
        *   Examples: "be certain to disconnect..."
        *   Sense 1 ("definite but not specified or identified") is the standard WordNet sense for "certain" used as a determiner or prenominal adjective meaning "specific" or "particular".
    *   Sentence: "...who have **certain** other side effects."
    *   Paraphrase: "...who have **specific** (but unnamed) other side effects."
    *   WordNet example match: "set aside a certain sum each week" parallels "have certain other side effects". Both use "certain" to refer to a specific subset that is not explicitly identified in that specific noun phrase.

4.  **Conclusion:** Sense 1 is the correct choice.

5.  **Format Output:**
    *   The instructions ask for a JSON object `{"sense_index": X}`.
    *   The sense index corresponds to the numbering in the list (1 through 7).
    *   Selected index: 1.

format: unknown

native_finish_reason: stop

provider: Amazon Bedrock

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: certain
Target surface form: certain
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have <t>certain</t> other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=certain%5:00:00:definite:00 | definition=definite but not specified or identified | examples=set aside a certain sum each week; to a certain degree
2. sense_key=certain%3:00:02:: | definition=having or feeling no doubt or uncertainty; confident and assured | synonyms=sure | examples=felt certain of success; was sure (or certain) she had seen it
3. sense_key=certain%3:00:01:: | definition=established beyond doubt or question; definitely known | examples=what is certain is that every effect must have a cause; it is certain that they were on the bus
4. sense_key=certain%3:00:03:: | definition=certain to occur; destined or inevitable; ; ; - Benjamin Franklin | synonyms=sure | examples=he was certain to fail; his fate is certain
5. sense_key=certain%3:00:05:: | definition=established irrevocably | synonyms=sealed | examples=his fate is sealed
6. sense_key=certain%5:00:00:reliable:00 | definition=reliable in operation or effect | synonyms=sure | examples=a quick and certain remedy; a sure way to distinguish the two
7. sense_key=certain%5:00:00:careful:00 | definition=exercising or taking care great enough to bring assurance | synonyms=sure | examples=be certain to disconnect the iron when you are through; be sure to lock the doors

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

[Assistant] sense_index": 1}

[User] Your previous answer was invalid. Choose one candidate index between 1 and 7. Return only valid JSON exactly like {"sense_index": 1}.

reasoning_content:
1.  **Analyze the Target:** The target word is "certain" used as an adjective in the phrase "certain other side effects".

2.  **Analyze the Context:**
    *   The text is from a medical label for the drug Alimta.
    *   The specific sentence: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have <t>certain</t> other side effects."
    *   Meaning: The text refers to specific, specific types of side effects that are not explicitly named in this sentence but are known or defined elsewhere (perhaps in the full prescribing information). They are definite instances of side effects, but the identity is not specified in this immediate context. It implies "some specific but unnamed" side effects.

3.  **Evaluate Candidate Senses:**

    *   **Sense 1:** `certain%5:00:00:definite:00` | definition="definite but not specified or identified" | examples="set aside a certain sum each week; to a certain degree".
        *   Analysis: This fits well. "Certain other side effects" means specific side effects (definite) but the text does not list them (not specified or identified). This is the "indefinite specific" usage of "certain" (e.g., "a certain Mr. Smith", "certain conditions apply").
        *   Match: High.

    *   **Sense 2:** `certain%3:00:02::` | definition="having or feeling no doubt or uncertainty; confident and assured" | synonyms="sure".
        *   Analysis: This refers to a person's state of mind (predicative position usually, e.g., "I am certain"). Here "certain" modifies "side effects". Side effects cannot be confident or assured.
        *   Match: Low.

    *   **Sense 3:** `certain%3:00:01::` | definition="established beyond doubt or question; definitely known".
        *   Analysis: This usually applies to facts (e.g., "It is certain that..."). While side effects are real, the usage here is selecting a subset of side effects ("certain other side effects"), not asserting the epistemic certainty of their existence in general. The construction "certain [noun]" usually maps to Sense 1.
        *   Match: Low.

    *   **Sense 4:** `certain%3:00:03::` | definition="certain to occur; destined or inevitable".
        *   Analysis: "Certain side effects" does not mean "inevitable side effects" in this context. It means "specific/particular side effects".
        *   Match: Low.

    *   **Sense 5:** `certain%3:00:05::` | definition="established irrevocably" | synonyms="sealed".
        *   Analysis: Relates to fate. Not applicable.
        *   Match: Low.

    *   **Sense 6:** `certain%5:00:00:reliable:00` | definition="reliable in operation or effect".
        *   Analysis: e.g., "a certain remedy". Side effects are not "reliable" in this sense.
        *   Match: Low.

    *   **Sense 7:** `certain%5:00:00:careful:00` | definition="exercising or taking care...".
        *   Analysis: Adverbial usage usually ("be certain to..."). Not applicable here.
        *   Match: Low.

4.  **Synthesize Decision:**
    The usage "certain [noun]" (attributive position) where the noun is not identified specifically corresponds to WordNet Sense 1 ("definite but not specified or identified"). The examples "set aside a certain sum" matches the structure "have certain other side effects". The patient has specific side effects, but the text doesn't say which ones right there.

5.  **Format Output:** The user wants a JSON object `{"sense_index": 1}`.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: other
Target surface form: other
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain <t>other</t> side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=other%3:00:00:: | definition=not the same one or ones already mentioned or implied; - the White Queen | examples=today isn't any other day; the construction of highways and other public works
2. sense_key=other%5:00:00:past:00 | definition=recently past | examples=the other evening
3. sense_key=other%5:00:02:past:00 | definition=belonging to the distant past | synonyms=early, former | examples=the early inhabitants of Europe; former generations
4. sense_key=other%5:00:00:strange:00 | definition=very unusual; different in character or quality from the normal or expected; - Lance Morrow | examples=a strange, other dimension...where his powers seemed to fail

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content: sense_index": 1}

reasoning_content:
1.  or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain **other** side effects."
    *   The context discusses medical treatment (Alimta) and its potential negative reactions (side effects).
    *   The sentence structure is "X or Y" where X is "blood counts are abnormal" and Y is "have certain other side effects".
    *   "Other" modifies "side effects". It implies side effects *in addition to* or *different from* the previously mentioned conditions (abnormal blood counts). It effectively categorizes side effects into a set, distinguishing the specific one mentioned (abnormal blood counts) from the rest of the set.

2.  **Analyze the candidate senses:**
    *   **Sense 1:** `other%3:00:00::` | definition="not the same one or ones already mentioned or implied". Examples: "today isn't any other day", "highways and other public works".
        *   This sense captures the meaning of "additional" or "different" items belonging to the general category being discussed but distinct from the specific one just named. In the text, "abnormal blood counts" is one side effect, and "other side effects" refers to the remaining members of the set of side effects not explicitly named there.
    *   **Sense 2:** `other%5:00:00:past:00` | definition="recently past". Example: "the other evening".
        *   This refers to time. The context is not temporal in the sense of "the other day". It's about **Sense 3:** `other%5:00:02:past:00` | definition="belonging to the distant past". Synonyms: early, former. Examples: "early inhabitants", "former generations".
        *   This refers to historical time. Not applicable.
    *   **Sense 4:** `other%5:00:00:strange:00` | definition="very unusual; different in character or quality...". Example: "a strange, other dimension".
        *   This implies a metaphysical or highly idiosyncratic usage. The side effects mentioned are medical events, not "strange dimensions" or qualities of "otherness" in a philosophical sense.

3.  **Compare Sense 1 to the context:**
    *   The phrase "certain other side effects" means "side effects distinct from abnormal blood counts".
    *   The definition "not the same one or ones already mentioned or implied" fits perfectly. The text mentions abnormal blood counts, then refers to the rest of the group as "other side effects".
    *   The example "the construction of highways and other public works" is analogous. Highways are mentioned; other public works (schools, hospitals, etc.) are the "other" ones. Here, abnormal blood counts are mentioned; nausea, fatigue, etc. would be the "other" side effects.

4.  **Conclusion:** Sense 1 is the correct choice.

5.  **Format the output:** The user requested a JSON object `{"sense_index": 1}`.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: other
Target surface form: other
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain <t>other</t> side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=other%3:00:00:: | definition=not the same one or ones already mentioned or implied; - the White Queen | examples=today isn't any other day; the construction of highways and other public works
2. sense_key=other%5:00:00:past:00 | definition=recently past | examples=the other evening
3. sense_key=other%5:00:02:past:00 | definition=belonging to the distant past | synonyms=early, former | examples=the early inhabitants of Europe; former generations
4. sense_key=other%5:00:00:strange:00 | definition=very unusual; different in character or quality from the normal or expected; - Lance Morrow | examples=a strange, other dimension...where his powers seemed to fail

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

[Assistant] sense_index": 1}

[User] Your previous answer was invalid. Choose one candidate index between 1 and 4. Return only valid JSON exactly like {"sense_index": 1}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation for the word "other" in the provided context.

**Context:**
"Alimta should only be given under the supervision... Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain **other** side effects. Alimta is not recommended..."

**Target Lemma:** other
**Target Surface Form:** other

**Candidate Senses:**
1. `sense_key=other%3:00:00::` | definition=not the same one or ones already mentioned or implied... | examples=today isn't any other day; the construction of highways and other public works
2. `sense_key=other%5:00:00:past:00` | definition=recently past | examples=the other evening
3. `sense_key=other%5:00:02:past:00` | definition=belonging to the distant past | synonyms=early, former | examples=the early inhabitants of Europe; former generations
4. `sense_key=other%5:00:00:strange:00` | definition=very unusual... | examples=a strange, other dimension...

**Analysis:**
*   **Contextual Meaning:** The sentence says "...patients whose blood counts are abnormal or who have certain **other** side effects."
*   The context mentions specific side effects previously (or implies a set): blood counts being abnormal is one set of side effects/conditions. The target word "other" introduces additional side effects that are different from the ones just mentioned (abnormal blood counts).
*   It functions as a determiner/adjective distinguishing between a set mentioned ("abnormal blood counts") and remaining ones ("other side effects").

**Evaluating Candidates:**
*   **Sense 1:** "not the same one or ones already mentioned or implied". This fits perfectly. The side effects mentioned are "abnormal blood counts". The "other" side effects are those not already mentioned or implied by "abnormal blood counts". Example: "highways and **other** public works" (highways mentioned, other public works distinct from that). Matches the usage here.
*   **Sense 2:** "recently past". E.g., "the other evening". This is a temporal usage. The context is about medical conditions/side effects, not time. Incorrect.
*   **Sense 3:** "belonging to the distant past". Synonyms: early, former. E.g., "former generations". This is also a temporal usage regarding the past. Incorrect.
*   **Sense 4:** "very unusual; different in character...". This usually implies a mystical or alien quality ("strange, other dimension"). The context refers to medical side effects which are distinct from the ones mentioned, but not necessarily "mystical" or "strange" in the specific sense defined here. It's the standard quantifier use of "other".

**Conclusion:**
Sense 1 is the standard definition for "other" used to refer to items remaining in a set after some have been specified.

**Instruction Check:**
"Return only a JSON object exactly like {"sense_index": 3}."

My previous output was messed up (missing curly braces). I need to provide strictly valid JSON.

Correct Sense Index: 1

provider: Together


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: side_effect
Target surface form: side effects
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other <t>side effects</t>. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=side_effect%1:26:00:: | definition=a secondary and usually adverse effect of a drug or therapy | examples=severe headaches are one of the side effects of the drug
2. sense_key=side_effect%1:19:00:: | definition=any adverse and unwanted secondary effect | synonyms=fallout | examples=a strategy to contain the fallout from the accounting scandal

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
Let me analyze the context and the candidate senses for "side effects" in this text.

Context analysis:
- This is a medical context about a chemotherapy drug called Alimta
- The text discusses how to reduce "side effects" through various measures (corticosteroid, folic acid, vitamin B12)
- The side effects mentioned are clearly adverse/negative effects of the drug therapy
- The text mentions that treatment may need to be delayed or discontinued if patients have certain "side effects"

Candidate sense 1:
- Definition: "a secondary and usually adverse effect of a drug or therapy"
- Example: "severe headaches are one of the side effects of the drug"
- This sense specifically mentions drugs and therapy, which matches our context perfectly
- The example is also about drug side effects, similar to our context

Candidate sense 2:
- Definition: "any adverse and unwanted secondary effect"
- Synonyms: "fallout"
- Example: "a strategy to contain the fallout from the accounting scandal"
- This sense is more general and the example is about a business/accounting context, not medical

The context is clearly about a medical drug (Alimta) and its adverse effects during chemotherapy treatment. This matches perfectly with sense 1, which specifically refers to "a secondary and usually adverse effect of a drug or therapy." The example in sense 1 is also about drug side effects, which aligns with our context.

Sense 2 is more general ("any adverse and unwanted secondary effect") and the example is about a business scandal's fallout, not medical side effects.

Therefore, the best indexed sense is sense 1.

provider: Friendli


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: use
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for <t>use</t> in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=use%1:04:00:: | definition=the act of using | synonyms=usage, utilization, utilisation, employment, exercise | examples=he warned against the use of narcotic drugs; skilled in the utilization of computers
2. sense_key=use%1:07:00:: | definition=what something is used for | synonyms=function, purpose, role | examples=the function of an auger is to bore holes; ballet is beautiful but what use is it?
3. sense_key=use%1:07:02:: | definition=a particular service | examples=he put his knowledge to good use; patrons have their uses
4. sense_key=use%1:22:00:: | definition=(economics) the utilization of economic goods to satisfy needs or in manufacturing | synonyms=consumption, economic consumption, usance, use of goods and services | examples=the consumption of energy has increased steadily
5. sense_key=use%1:04:01:: | definition=(psychology) an automatic pattern of behavior in reaction to a specific situation; may be inherited or acquired through frequent repetition | synonyms=habit | examples=owls have nocturnal habits; she had a habit twirling the ends of her hair
6. sense_key=use%1:04:02:: | definition=exerting shrewd or devious influence especially for one's own advantage | synonyms=manipulation | examples=his manipulation of his friends was scandalous
7. sense_key=use%1:07:03:: | definition=(law) the exercise of the legal right to enjoy the benefits of owning property | synonyms=enjoyment | examples=we were given the use of his boat

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the target word and context**:
    *   Target lemma: `use` (noun).
    *   Context: "Alimta is not recommended for use in patients with moderate or severe kidney problems."
    *   The sentence talks about a medical procedure/treatment involving a drug (Alimta). Specifically, it talks about whether the drug should be applied/administered to a specific group of patients. The phrase is "recommended for use in patients".

2.  **Analyze the candidate senses**:

    *   **Sense 1**: `use%1:04:00::` | Definition: "the act of using" | Synonyms: usage, utilization, employment, exercise | Examples: "he warned against the use of narcotic drugs", "skilled in the utilization of computers".
        *   Analysis: This sense refers to the action or process of using something. The example "use of narcotic drugs" is extremely close to "use [of Alimta] in patients". The context describes the administration/application of the drug, which fits "the act of using".

    *   **Sense 2**: `use%1:07:00::` | Definition: "what something is used for" | Synonyms: function, purpose, role | Examples: "the function of an auger is to bore holes", "ballet is beautiful but what use is it?".
        *   Analysis: This sense refers to the purpose or function of an object. The context isn't asking "what is the use of Alimta?" (which would mean purpose), but rather discusses the *act* of administering it to specific patients. "Not recommended for use" doesn't mean "not recommended for its purpose"; it means "not recommended to be used".

    *   **Sense 3**: `use%1:07:02::` | Definition: "a particular service" | Examples: "he put his knowledge to good use", "patrons have their uses".
        *   Analysis: This is an idiom-like usage regarding usefulness or benefit. The context is about medical administration, not a service rendered by a person or the utility of an object in a general sense.

    *   **Sense 4**: `use%1:22:00::` | Definition: "(economics) the utilization of economic goods..." | Synonyms: consumption...
        *   Analysis: Economic context. Irrelevant here.

    *   **Sense 5**: `use%1:04:01::` | Definition: "(psychology) an automatic pattern of behavior..." | Synonyms: habit.
        *   Analysis: Wrong meaning. This is about habit.

    *   **Sense 6**: `use%1:04:02::` | Definition: "exerting shrewd or devious influence..." | Synonyms: manipulation.
        *   Analysis: Wrong meaning.

    *   **Sense 7**: `use%1:07:03::` | Definition: "(law) the exercise of the legal right..." | Synonyms: enjoyment.
        *   Analysis: Legal context. Irrelevant.

3.  **Select the best sense**:
    *   The phrase "recommended for use" corresponds to the "act of using" or "utilization" of the drug.
    *   Sense 1 definition: "the act of using". Synonyms: "utilization".
    *   Sense 1 example: "he warned against the use of narcotic drugs". This is semantically very similar to "not recommended for use... in patients".
    *   Therefore, Sense 1 is the correct choice.

4.  **Format the output**:
    *   Return JSON: `{"sense_index": 1}`.

provider: DigitalOcean


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in <t>patients</t> with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the target lemma and form:**
    *   Lemma: patient
    *   Surface form: patients (plural noun).

2.  **Analyze the context:**
    *   The text discusses a medical drug (Alimta), dosage calculation based on height and weight, intravenous infusion, side effects, corticosteroids, folic acid, vitamin B12, cisplatin, kidney problems, etc.
    *   The specific target sentence is: "Alimta is not recommended for use in <t>patients</t> with moderate or severe kidney problems."
    *   The surrounding text consistently refers to people receiving medical care ("patients should take...", "treatment should be delayed... in patients...").

3.  **Analyze the candidate senses:**
    *   **Sense 1:** `patient%1:18:00::` | Definition: "a person who requires medical care" | Example: "the number of emergency patients has grown rapidly".
        *   This fits the context perfectly. The text describes a drug prescribed for specific people (those with cancer, implicitly, given the chemotherapy context).
    *   **Sense 2:** `patient%1:10:00::` | Definition: "the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause" | Synonyms: "affected role, patient role".
        *   This is a linguistic/grammatical definition referring to thematic roles (like subject/object relations in semantics). While the people in the text act as the "patient" in the semantic sense (they are affected by the treatment), the *word* "patients" in this medical text refers to the *people* themselves, not the grammatical role. The text is not discussing linguistics; it's discussing medical treatment.

4.  **Compare and Decide:**
    *   Context: Medical instructions/clinical trial summary.
    *   Target word: "patients" (people).
    *   Sense 1 refers to the medical definition of a person under medical care.
    *   Sense 2 refers to the linguistic definition.
    *   Sense 1 is the clear winner. The sentence talks about "patients with ... kidney problems", referring to the category of people, not the grammatical role they play.

5.  **Format Output:**
    *   The user wants a JSON object `{"sense_index": X}` where X corresponds to the index in the list provided.
    *   The list starts with index 1 for sense_key=patient%1:18:00::.
    *   Therefore, index 1 is the correct choice.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: moderate
Target surface form: moderate
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with <t>moderate</t> or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=moderate%3:00:00:: | definition=being within reasonable or average limits; not excessive or extreme | examples=moderate prices; a moderate income
2. sense_key=moderate%5:00:00:mild:00 | definition=not extreme | synonyms=temperate | examples=a moderate penalty; temperate in his response to criticism
3. sense_key=moderate%5:00:00:temperate:00 | definition=marked by avoidance of extravagance or extremes | synonyms=restrained | examples=moderate in his demands; restrained in his response

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "moderate" in the context: "Alimta is not recommended for use in patients with moderate or severe kidney problems."

Let me analyze the context:
- The sentence discusses kidney problems
- "moderate or severe" - this is a scale of severity
- "moderate" here describes the degree/intensity of kidney problems
- It's being contrasted with "severe" - so moderate is in the middle range of severity (mild → moderate → severe)

Let me look at the candidate senses:

1. sense_key=moderate%3:00:00:: | definition=being within reasonable or average limits; not excessive or extreme | examples=moderate prices; a moderate income
- This is about being within limits, reasonable or average
- Examples are about prices and income - quantitative things

2. sense_key=moderate%5:00:00:mild:00 | definition=not extreme | synonyms=temperate | examples=a moderate penalty; temperate in his response to criticism
- This is about not being extreme
- Examples include "a moderate penalty" which is similar - describing degree of something negative
- The synonym "temperate" suggests avoiding extremes

3. sense_key=moderate%5:00:00:temperate:00 | definition=marked by avoidance of extravagance or extremes | synonyms=restrained | examples=moderate in his demands; restrained in his response
- This seems to be about behavior and self-restraint
- Examples are about demands and responses - behavioral contexts
- This doesn't fit the medical context

The context is about the degree/severity of kidney problems. "Moderate" here means "not extreme" in terms of severity - it's between mild and severe.

Sense 1 talks about "reasonable or average limits; not excessive or extreme" with examples about prices and income - quantitative/amount contexts.

Sense 2 has definition "not extreme" with example "a moderate penalty" which is similar to "moderate kidney problems" - describing degree of severity.

Sense 3 is about behavioral restraint, which doesn't fit.

Between sense 1 and sense 2:
- Sense 1: "being within reasonable or average limits; not excessive or extreme" - this could work for severity
- Sense 2: "not extreme" with example "a moderate penalty" - this is about intensity/degree of something negative

The example "a moderate penalty" in sense 2 is very similar to "moderate kidney problems" - both describe something negative that isn't extreme. The medical context is about severity/intensity, not about amounts or reasonable limits.

I think sense 2 is the best fit because:
1. The definition "not extreme" captures the meaning in this medical context
2. The example "a moderate penalty" is analogous to "moderate kidney problems" - both describe degree of severity of something negative
3. The synonym "temperate" relates to avoiding extremes

Sense 1 could also work since it mentions "not excessive or extreme" but the examples are about prices and income which are quantity/amount contexts rather than severity/intensity contexts.

I'll go with sense 2.

provider: AtlasCloud


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: severe
Target surface form: severe
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or <t>severe</t> kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=severe%5:00:00:intense:00 | definition=intensely or extremely bad or unpleasant in degree or quality | synonyms=terrible, wicked | examples=severe pain; a severe case of flu
2. sense_key=severe%5:00:00:strong:00 | definition=very strong or vigorous | synonyms=hard, knockout | examples=strong winds; a hard left to the chin
3. sense_key=severe%5:00:00:plain:01 | definition=severely simple | synonyms=austere, stark, stern | examples=a stark interior
4. sense_key=severe%5:00:02:nonindulgent:00 | definition=unsparing and uncompromising in discipline or judgment; - H.G.Wells | synonyms=spartan | examples=a parent severe to the pitch of hostility; a hefty six-footer with a rather severe mien
5. sense_key=severe%5:00:00:critical:03 | definition=causing fear or anxiety by threatening great harm | synonyms=dangerous, grave, grievous, serious, life-threatening | examples=a dangerous operation; a grave situation
6. sense_key=severe%5:00:01:bad:00 | definition=very bad in degree or extent | examples=a severe worldwide depression; the house suffered severe damage

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the Context:** The target word is "severe" in the phrase "severe kidney problems". The sentence is: "Alimta is not recommended for use in patients with moderate or severe kidney problems." The text discusses medical treatment, side effects, and contraindications based on patient health status.

2.  **Analyze the Candidate Senses:**

    *   **Sense 1:** `intensely or extremely bad or unpleasant in degree or quality`. Examples: "severe pain", "severe case of flu". Synonyms: "terrible", "wicked".
        *   *Evaluation:* This fits well with medical conditions. Kidney problems can be "bad or unpleasant". "Severe pain" is a classic collocation. This sense captures the intensity of the condition.

    *   **Sense 2:** `very strong or vigorous`. Examples: "strong winds", "a hard left to the chin". Synonyms: "hard", "knockout".
        *   *Evaluation:* This usually applies to physical forces or impacts (wind, punches). It does not fit medical conditions like kidney problems well.

    *   **Sense 3:** `severely simple`. Examples: "a stark interior". Synonyms: "austere", "stark", "stern".
        *   *Evaluation:* This refers to style, architecture, or demeanor. Not applicable to kidney problems.

    *   **Sense 4:** `unsparing and uncompromising in discipline or judgment`. Examples: "parent severe to the pitch of hostility". Synonyms: "spartan".
        *   *Evaluation:* This refers to human behavior or personality. Not applicable.

    *   **Sense 5:** `causing fear or anxiety by threatening great harm`. Examples: "a dangerous operation", "a grave situation". Synonyms: "dangerous", "grave", "grievous", "serious", "life-threatening".
        *   *Evaluation:* This is a strong contender. Severe kidney problems are indeed dangerous/life-threatening. However, the core meaning in medical grading (mild, moderate, severe) usually refers to the *degree* or *intensity* of the condition itself, rather than just the potential threat, though the two are linked.

    *   **Sense 6:** `very bad in degree or extent`. Examples: "severe worldwide depression", "the house suffered severe damage". Synonyms: (None listed in the snippet, but implied synonyms are usually 'serious', 'bad', 'grievous').
        *   *Evaluation:* This is very similar to Sense 1. It highlights degree/extent. "Severe kidney problems" implies the problems are of a high degree.

3.  **Compare Sense 1, Sense 5, and Sense 6:**

    *   *Sense 1 (intensely bad/unpleasant):* Focuses on the quality/degree of the suffering or condition. "Severe pain" fits here.
    *   *Sense 5 (threatening great harm):* Focuses on the potential outcome/danger. "Severe injury" fits here.
    *   *Sense 6 (very bad in degree/extent):* Focuses on the magnitude of the phenomenon. "Severe damage".

    Let's look at WordNet 3.1 (or similar derivations) structure for "severe".
    The distinction between Sense 1 and Sense 6 in the provided list is subtle.
    Sense 1: "intensely or extremely bad or unpleasant in degree or quality" (Examples: severe pain, severe case of flu).
    Sense 6: "very bad in degree or extent" (Examples: severe worldwide depression, severe damage).

    In medical contexts (e.g., CTCAE grading), "severe" grades the intensity of the symptom or the condition.
    "Kidney problems" constitutes a medical condition.
    Sense 1 examples ("severe pain", "severe case of flu") are strictly medical/physical experiences.
    Sense 5 examples ("dangerous operation", "grave situation") are more about the *risk* or *situation* rather than a specific physiological dysfunction grade. While severe kidney problems are dangerous, "severe" is grading the dysfunction.
    Sense 6 examples ("depression", "damage") are broad.

    Let's look closely at Sense 1 vs Sense 6.
    Sense 1 explicitly mentions "unpleasant in degree or quality" with "severe pain" and "severe case of flu". These are the closest analogs to "severe kidney problems". A "severe case" of something is the standard medical collocation.
    Sense 6 examples are "severe worldwide depression" (economic) or "severe damage" (physical object). While "damage" is close, Sense 1's examples are specifically physiological/medical conditions (pain, flu).

    Wait, let's re-read the glosses.
    Sense 1 gloss: "intensely or extremely bad or unpleasant in degree or quality".
    Sense 6 gloss: "very bad in degree or extent".

    "Kidney problems" are a condition. The grading is Mild -> Moderate -> Severe. This indicates high intensity/badness of the condition.
    Sense 1's example "severe case of flu" aligns perfectly with "severe kidney problems" (a medical condition/case).
    Sense 5 is about "dangerous/life-threatening". While true, "severe" in medical texts distinguishes intensity, not just danger (though they correlate). A mild condition can be dangerous, but "severe" specifically refers to the degree of the pathology.
    Therefore, Sense 1 seems the most precise for "severe [medical condition]".

    Let's double check Sense 5 synonyms: "dangerous, grave, grievous, serious, life-threatening".
    Let's double check Sense 1 synonyms: "terrible, wicked".

    Actually, usually in WordNet, the sense for "severe" regarding illness/ailments often falls under the definition "intensely or extremely bad or unpleasant in degree or quality" (Sense 1). "Severe pain" and "severe case of flu" are the examples there. "Kidney problems" is a condition similar to a "case of flu" or "pain".
    Sense 5 ("causing fear... threatening great harm") is often used for "severe storm", "severe shortage", or situations. "Severe kidney problems" are a state of the body, not primarily a "situation" in the narrative sense (like a "grave situation").

    There is a slight overlap with Sense 6 ("severe damage"), but kidney problems are a condition/disease, not just "damage" (though they result from damage). Sense 1's "severe case of flu" is the closest semantic neighbor to "severe kidney problems".

    Therefore, Sense 1 is the correct choice.

    Let's verify Sense 1 again.
    Index 1: "intensely or extremely bad or unpleasant in degree or quality". Examples: "severe pain", "a severe case of flu".
    Context: "moderate or severe kidney problems".
    This fits the medical grading of a condition perfectly.

    Sense 5 ("causing fear... threatening great harm") is arguably true, but usually "severe" in medical staging refers to intensity (Sense 1) rather than just the potential for harm (though that is implied). If the text said "the patient's condition is severe", it might lean toward Sense 5/6, but "severe kidney problems" describes the pathology itself, making Sense 1 (exemplified by "severe case of flu") the best fit.

    One might argue for Sense 6 ("very bad in degree or extent"). "Severe damage" vs "Severe kidney problems". However, "pain" and "flu" (Sense 1 examples) are pathologies/symptoms. "Depression" (Sense 6 example) can be economic. "Damage" is structural. "Kidney problems" are pathologies. Thus Sense 1 is better.

provider: Parasail


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: problem
Target surface form: problems
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney <t>problems</t>. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=problem%1:26:00:: | definition=a state of difficulty that needs to be resolved | synonyms=job | examples=she and her husband are having problems; it is always a job to contact him
2. sense_key=problem%1:10:00:: | definition=a question raised for consideration or solution | examples=our homework consisted of ten problems to solve
3. sense_key=problem%1:09:00:: | definition=a source of difficulty | synonyms=trouble | examples=one trouble after another delayed the job; what's the problem?

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the target word and context:**
    *   Target lemma: problem
    *   Target surface form: problems
    *   Context snippet: "Alimta is not recommended for use in patients with moderate or severe kidney <t>problems</t>."

2.  **Analyze the candidate senses:**

    *   **Sense 1:** `problem%1:26:00::`
        *   Definition: "a state of difficulty that needs to be resolved"
        *   Synonyms: job
        *   Examples: "she and her husband are having problems", "it is always a job to contact him"
        *   Analysis: This sense refers to a situation or state (often interpersonal or abstract) involving difficulty. While medical issues are a state of difficulty, the "job" synonym fits poorly here. The examples are more about general life difficulties or hassles.

    *   **Sense 2:** `problem%1:10:00::`
        *   Definition: "a question raised for consideration or solution"
        *   Examples: "our homework consisted of ten problems to solve"
        *   Analysis: This is strictly about academic or mathematical problems/questions. Not applicable to kidney issues.

    *   **Sense 3:** `problem%1:09:00::`
        *   Definition: "a source of difficulty"
        *   Synonyms: trouble
        *   Examples: "one trouble after another delayed the job", "what's the problem?"
        *   Analysis: This sense identifies the specific entity or condition that causes difficulty. In the context "kidney problems", the kidneys are the source of the trouble/difficulty. The phrase "kidney problems" is a standard collocation referring to medical conditions or diseases. A disease or medical condition acts as a "source of difficulty" for the patient. Synonyms like "trouble" fit better here ("kidney trouble") than "job" does.

3.  **Compare and Disambiguate:**
    *   The context refers to a medical condition ("kidney problems").
    *   Sense 2 is clearly wrong (math/questions).
    *   Sense 1 implies a state of affairs or a task. While a medical condition creates a state of difficulty, Sense 3 ("source of difficulty") aligns well with the physical/medical condition acting as the root cause of the trouble. WordNet's hierarchy often puts diseases/conditions under "source of difficulty" or related concepts.
    *   Let's look at the synonyms again.
        *   Sense 1: job. "Kidney jobs"? No.
        *   Sense 3: trouble. "Kidney trouble"? Yes, this is a common synonym.
    *   Let's look at the examples.
        *   Sense 1: "having problems" (relationship). This is a state.
        *   Sense 3: "what's the problem?" (asking for the source of the issue).
    *   "Kidney problems" are specific conditions causing dysfunction. They are sources of difficulty. In many WSD frameworks, medical "problems" or "issues" map to the "trouble/source of difficulty" sense rather than the "state of difficulty needing resolution" sense (which often implies a puzzle or a complex situation to navigate). Although the boundaries can be fuzzy, Sense 3 is the stronger fit because of the synonym "trouble" and the nature of a medical condition as a source of physical distress.

4.  **Select the best index:**
    *   Sense 1: State of difficulty.
    *   Sense 2: Question.
    *   Sense 3: Source of difficulty (trouble).
    *   Context: Medical condition (kidney problems).
    *   Medical conditions are sources of physical difficulty/trouble.
    *   Therefore, Sense 3 is the best choice.

5.  **Final Output Generation:**
    *   Format: JSON `{"sense_index": 3}`.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: more
Target surface form: more
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For <t>more</t> information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=more%3:00:01:: | definition=(comparative of `much' used with mass nouns) a quantifier meaning greater in size or amount or extent or degree | synonyms=more than | examples=more land; more support
2. sense_key=more%3:00:02:: | definition=(comparative of `many' used with count nouns) quantifier meaning greater in number | examples=a hall with more seats; we have no more bananas

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the target word and context:**
    *   Target lemma: `more`
    *   Target surface form: `more`
    *   Context sentence: "For <t>more</t> information, see the Summary of Product Characteristics (also part of the EPAR)."

2.  **Analyze the candidate senses:**
    *   **Sense 1:** `more%3:00:01::`
        *   Definition: (comparative of `much' used with mass nouns) a quantifier meaning greater in size or amount or extent or degree.
        *   Synonyms: more than.
        *   Examples: more land; more support.
        *   Key feature: Used with *mass nouns* (uncountable nouns like land, support, water, information).

    *   **Sense 2:** `more%3:00:02::`
        *   Definition: (comparative of `many' used with count nouns) quantifier meaning greater in number.
        *   Examples: a hall with more seats; we have no more bananas.
        *   Key feature: Used with *count nouns* (plural countable nouns like seats, bananas, people).

3.  **Evaluate the target word in context:**
    *   The phrase is "For more information..."
    *   The noun being modified is "information".
    *   Is "information" a mass noun or a count noun?
        *   "Information" is generally an uncountable noun (mass noun) in standard English. We say "a piece of information" rather than "an information" or "informations" (in standard usage).
    *   Therefore, the usage corresponds to the comparative of "much" (more information) rather than the comparative of "many" (which would apply to things like "more details" or "more facts").

4.  **Match with senses:**
    *   Sense 1 explicitly mentions mass nouns and gives examples like "more land" and "more support". "Information" fits this category. The definition "greater in size or amount or extent or degree" applies to the amount of information.
    *   Sense 2 explicitly mentions count nouns and gives examples like "more seats". This does not fit "information".

5.  **Conclusion:**
    *   The correct sense is Sense 1.

6.  **Format the output:**
    *   The user requested a JSON object `{"sense_index": X}`.
    *   The chosen sense index is 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: information
Target surface form: information
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more <t>information</t>, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=information%1:10:00:: | definition=a message received and understood | synonyms=info
2. sense_key=information%1:09:00:: | definition=knowledge acquired through study or experience or instruction
3. sense_key=information%1:10:02:: | definition=formal accusation of a crime
4. sense_key=information%1:14:00:: | definition=a collection of facts from which conclusions may be drawn | synonyms=data | examples=statistical data
5. sense_key=information%1:07:00:: | definition=(communication theory) a numerical measure of the uncertainty of an outcome | synonyms=selective information, entropy | examples=the signal contained thousands of bits of information

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  Product Characteristics (also part of the EPAR)." The broader context is a medical text describing a drug (Alimta), its administration, side effects, and precautions. The specific usage refers to seeking further details or knowledge about the drug from a specific document (Summary of Product Characteristics).
3.  **Analyze the Candidate Senses:**
    *   **Sense 1:** "a message received and understood" (synonyms: info). This is very general. It fits the idea of acquiring knowledge, but often implies a specific transaction of a message.
    *   **Sense 2:** "knowledge acquired through study or experience or instruction". This refers to the *possession* of knowledge or the general body of knowledge. "For more knowledge..." sounds a bit awkward compared to "For more details/facts...".
    *   **Sense 3:** "formal accusation of a crime". This is a legal term. The context is medical/pharmaceutical, not legal (in the sense of criminal charges). Incorrect.
    *   **Sense 4:** "a collection of facts from which conclusions may be drawn" (synonyms: data). Examples: "statistical data". The context invites the reader to consult a document for facts/details. "For more information" usually means "For more facts/details/data about this topic". The Summary of Product Characteristics contains a collection of facts (dosage, composition, trials). This sense aligns well with the objective content of a document.
    *   **Sense 5:** "(communication theory) a numerical measure of the uncertainty of an outcome" (synonyms: entropy). This is specific to information theory/physics. Incorrect.

4.  **Compare Sense 1 and Sense 4:**
    *   Sense 1 ("a message received and understood") is often used for signals or communications.
    *   Sense 2 ("knowledge acquired...") is often about the state of knowing.
    *   Sense 4 ("a collection of facts...", synonyms: data) fits the context of reading a document to get specific details about a drug. When someone asks for "information" in a reference context (like a brochure or manual), they are asking for data, facts, and details.

    Let's look at how WordNet definitions map to "For more information, see..."
    If I see a document, it contains facts/data.
    Sense 1 is often: "I have information for you" (a specific message).
    Sense 4 is often: "The library has a lot of information" (facts/data).
    The phrase "For more information" is a standard discourse marker. In this specific slot, it functions as "For more facts/details".
    WordNet sense 4 (data) is defined as "a collection of facts from which conclusions may be drawn". A Summary of Product Characteristics is exactly a collection of facts.
    Sense 1 is defined as "a message received and understood". While reading the document involves receiving a message, the content itself—what constitutes the "information"—is better described as a collection of facts (Sense 4).

    However, let's re-evaluate Sense 1 vs Sense 2 vs Sense 4.
    Common usage: "I need information." -> usually means facts/knowledge.
    Sense 2: "knowledge acquired...". This is the abstract mass noun of knowing.
    Sense 4: "collection of facts.

    Let's check the specific examplesistical data".
    Let's check usage in similar contexts. "For more information, visit our website." The website contains data/facts.
    "Information" in the sense of "facts provided or learned about something or someone" (Oxford Languages) is the standard definition.
    WordNet Sense 4 ("collection of facts... data") is the closest to "facts/details" in a document.

    Let doesn't fitactic slot "For more [noun]". "Information" here acts as the content. Sense 4 (data) fits "content".

    Let's look at Sense 1 again. Synonym "info". "Info" is very informal. The text is formal. "For more info" is common, but "For more information" usually refers to the content of the document.
    Sense 1 focuses on the act of transmission ("message received").
    Sense 4 focuses on the content ("collection of facts").

    Decision: Sense 4 seems the most appropriate for "information" contained in a document/report used for reference.

    *Self-Correction/Refinement:*
    Wait, let's look at the WordNet hierarchy and common WSD tasks.
    Sense 1: "a message received and understood".
    Sense 2: "knowledge acquired through study or experience or instruction".
    Sense 4: "a collection of facts from which conclusions may be drawn" (syn: data).

    If I say "Can you give me some information?", I am asking for facts.
    If I say "The information in this book is outdated", I am referring to facts/data.
    The context is: "For more information, see the Summary...".
    The Summary contains facts. Sense 4 matches "data" and "statistical data".

    Let's try Sense 2. "Knowledge acquired..." implies a state of the mind. The document provides the raw material (facts/data) to acquire knowledge. The document doesn't contain "knowledge" (a mental state); it contains "information" (facts/data).
    Therefore, Sense 4 is better than Sense 2.

    Is Sense 4 better than Sense 1?
    Sense 1: "a message". Is a drug label a message? Yes, technically. Is it received and understood? Yes.
    However, "information" as "data" (Sense 4) is a distinct sense in WordNet often used for technical/scientific contexts where facts are paramount. The example "statistical data" supports this. Medical information is heavily fact-based (data).

    Let's look at Sense 1's synonyms: info.
    Let's look at Sense 4's synonyms: data.
    "For more data, see the Summary..." -> Plausible, though "information" is the standard term.
    "For more info, see the Summary..." -> Plausible.

    Let's consider the nuance. Sense 1 is the most general, hypernymic sense in WordNet (often 1:10:00 is high up).
    WordNet 3.0/3.1:
    1. information, info (a message received and understood).
    2. information (knowledge acquired through study...).
    4. information, data (a collection of facts...).

    If the context implies facts, figures, and specifics from a document, Sense 4 is often the preferred fine-grained sense in WSD datasets (like SemCor/ONTONotes if memory serves). "Information" in medical texts usually refers to objective data/facts.

    Let's compare Sense 1 and Sense 4 again.
    The sentence "For more information, see the Summary..." implies "For more facts/details".
    Definition 4: "a collection of facts".
    Definition 1: "a message".
    While a document is a message, the *purpose* of "more information" here is to provide facts. Sense 4 specifically lists "data" as a synonym. Medical information is data.

    Therefore, Sense 4 is the best fit.