[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: form
Target surface form: form
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=form%1:10:00:: | definition=the phonological or orthographic sound or appearance of a word that can be used to describe or identify something | synonyms=word form, signifier, descriptor | examples=the inflected forms of a word can be represented by a stem and a list of inflections to be attached
2. sense_key=form%1:09:01:: | definition=a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety | examples=sculpture is a form of art; what kinds of desserts are there?
3. sense_key=form%1:09:00:: | definition=a perceptual structure | synonyms=shape, pattern | examples=the composition presents problems for students of musical form; a visual pattern must include not only objects but the spaces between them
4. sense_key=form%1:07:01:: | definition=any spatial attributes (especially as defined by outline) | synonyms=shape, configuration, contour, conformation | examples=he could barely make out their shapes
5. sense_key=form%1:08:00:: | definition=alternative names for the body of a human being | synonyms=human body, physical body, material body, soma, build, figure | examples=Leonardo studied the human body; he has a strong physique
6. sense_key=form%1:03:00:: | definition=the spatial arrangement of something as distinct from its substance | synonyms=shape | examples=geometry is the mathematical science of shape
7. sense_key=form%1:07:00:: | definition=the visual appearance of something or someone | synonyms=shape, cast | examples=the delicate cast of his features
8. sense_key=form%1:10:01:: | definition=a printed document with spaces in which to write | examples=he filled out his tax form
9. sense_key=form%1:14:02:: | definition=(biology) a group of organisms within a species that differ in trivial ways from similar groups | synonyms=variant, strain, var. | examples=a new strain of microorganisms
10. sense_key=form%1:10:02:: | definition=an arrangement of the elements in a composition or discourse | examples=the essay was in the form of a dialogue; he first sketches the plot in outline form
11. sense_key=form%1:07:03:: | definition=a particular mode in which something is manifested | examples=his resentment took the form of extreme hostility
12. sense_key=form%1:26:00:: | definition=(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary | synonyms=phase | examples=the reaction occurs in the liquid phase of the system
13. sense_key=form%1:14:00:: | definition=a body of students who are taught together | synonyms=class, grade, course | examples=early morning classes are always sleepy
14. sense_key=form%1:07:02:: | definition=an ability to perform well | examples=he was at the top of his form; the team was off form last night
15. sense_key=form%1:06:00:: | definition=a life-size dummy used to display clothes | synonyms=mannequin, manikin, mannikin, manakin
16. sense_key=form%1:06:01:: | definition=a mold for setting concrete | examples=they built elaborate forms for pouring the foundation

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "form" in the context: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides..."

Let me analyze the context:
- This is about a medicine/drug (pemetrexed) being converted in the body
- It's converted into an "active form"
- This is about the chemical/molecular state of the substance

Looking at the candidate senses:

1. form%1:10:00:: - phonological/orthographic appearance of a word - NOT relevant
2. form%1:09:01:: - category of things distinguished by common characteristic - could be loosely related but not specific enough
3. form%1:09:00:: - perceptual structure - not quite right
4. form%1:07:01:: - spatial attributes defined by outline - not relevant
5. form%1:08:00:: - alternative names for human body - not relevant
6. form%1:03:00:: - spatial arrangement distinct from substance - not relevant
7. form%1:07:00:: - visual appearance - not quite right
8. form%1:10:01:: - printed document - not relevant
9. form%1:14:02:: - biology: group of organisms - not quite right for chemistry context
10. form%1:10:02:: - arrangement of elements in composition - not relevant
11. form%1:07:03:: - particular mode in which something is manifested - this could work! "active form" is a mode/state in which the substance is manifested
12. sense_key=form%1:26:00:: - physical chemistry: distinct state of matter - THIS IS IT! This is about chemistry, a "distinct state of matter" - pemetrexed is converted into an active form/state. This is about the chemical/molecular form of the substance.

Sense 12 is the best match. This is about a chemical/biochemical context where pemetrexed is converted into an active "form" - meaning a particular chemical state or phase of the molecule. The gloss mentions "physical chemistry" and "a distinct state of matter" which fits perfectly with how drugs are described as having different forms (active form, inactive form, etc.).

So the answer should be sense_index: 12


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: block
Target surface form: blocks
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=block%2:35:00:: | definition=render unsuitable for passage | synonyms=barricade, blockade, stop, block off, block up, bar | examples=block the way; barricade the streets
2. sense_key=block%2:41:00:: | definition=hinder or prevent the progress or accomplishment of | synonyms=obstruct, blockade, hinder, stymie, stymy, embarrass | examples=His brother blocked him at every turn
3. sense_key=block%2:41:01:: | definition=stop from happening or developing | synonyms=stop, halt, kibosh | examples=Block his election; Halt the process
4. sense_key=block%2:32:00:: | definition=interfere with or prevent the reception of signals | synonyms=jam | examples=Jam the Voice of America; block the signals emitted by this station
5. sense_key=block%2:41:03:: | definition=run on a block system | examples=block trains
6. sense_key=block%2:39:05:: | definition=interrupt the normal function of by means of anesthesia | examples=block a nerve; block a muscle
7. sense_key=block%2:39:00:: | definition=shut out from view or get in the way so as to hide from sight | synonyms=obstruct | examples=The thick curtain blocked the action on the stage; The trees obstruct my view of the mountains
8. sense_key=block%2:35:03:: | definition=stamp or emboss a title or design on a book with a block | examples=block the book cover
9. sense_key=block%2:35:02:: | definition=obstruct | synonyms=stuff, lug, choke up | examples=My nose is all stuffed; Her arteries are blocked
10. sense_key=block%2:35:12:: | definition=block passage through | synonyms=obstruct, obturate, impede, occlude, jam, close up | examples=obstruct the path
11. sense_key=block%2:35:06:: | definition=support, secure, or raise with a block | examples=block a plate for printing; block the wheels of a car
12. sense_key=block%2:33:00:: | definition=impede the movement of (an opponent or a ball) | synonyms=parry, deflect | examples=block an attack
13. sense_key=block%2:31:00:: | definition=be unable to remember | synonyms=forget, blank out, draw a blank | examples=I'm drawing a blank; You are blocking the name of your first wife!
14. sense_key=block%2:30:01:: | definition=shape by using a block | examples=Block a hat; block a garment
15. sense_key=block%2:30:00:: | definition=shape into a block or blocks | examples=block the graphs so one can see the results clearly
16. sense_key=block%2:30:02:: | definition=prohibit the conversion or use of (assets) | synonyms=freeze, immobilize, immobilise | examples=Blocked funds; Freeze the assets of this hostile government

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

finish_reason: stop

role: assistant

reasoning_content:
1.  **Analyze the context**:
    *   Sentence: "In the body, pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides..."
    *   Subject: "an active form" (referring to pemetrexed, a medicine).
    *   Object: "the activity of the enzymes".
    *   Domain: Medical/Pharmacological mechanism of action.
    *   Meaning: The drug interferes with, stops, or inhibits the normal function of the enzymes. It prevents them from doing their job (producing nucleotides).

2.  **Evaluate the candidate senses**:

    *   *Sense 1 (block%2:35:00::)*: "render unsuitable for passage". Physical obstruction (streets, ways). Not about abstract activity/enzymes.
    *   *Sense 2 (block%2:41:00::)*: "hinder or prevent the progress or accomplishment of". Synonyms: obstruct, hinder, stymie. Example: "His brother blocked him at every turn." This is close in an abstract sense, but often implies a struggle or opposition. It's possible, but there might be a more specific biological sense.
    *   *Sense 3 (block%2:41:01::)*: "stop from happening or developing". Synonyms: stop, halt. Example: "Block his election". Also abstract, fits "block activity", but usually implies stopping an event/process entirely rather than inhibiting a biological function.
    *   *Sense 4 (block%2:32:00::)*: "interfere with or prevent the reception of signals". Synonyms: jam. Example: "Jam the Voice of America". Specific to signals/broadcasts. Not quite right for enzyme activity, though enzymes send/proccess chemical signals (in a way), but "jam" is the telltale synonym here.
    *   *Sense 5 (block%2:41:03::)*: "run on a block system". Train context. Irrelevant.
    *   *Sense 6 (block%2:39:05::)*: "interrupt the normal function of by means of anesthesia". Examples: "block a nerve". This is the specific medical/biological sense of preventing a physiological function. While the context is not anesthesia (it's chemotherapy), the core meaning is "interrupt the normal function of [a biological entity]". The definition "interrupt the normal function of" fits perfectly with "blocks the activity of the enzymes".
    *   *Sense 7 (block%2:39:00::)*: "shut out from view". Visual obstruction. Irrelevant.
    *   *Sense 8 (block%2:35:03::)*: "stamp or emboss". Printing context. Irrelevant.
    *   *Sense 9 (block%2:35:02::)*: "obstruct". Examples: "stuffed nose", "arteries are blocked". Physical obstruction of flow. Enzymes aren't "stuffed" or "occluded" like a pipe; their activity is inhibited.
    *   *Sense 10 (block%2:35:12::)*: "block passage through". Synonyms: occlude, impede. Similar to 1 and 9. Physical blockage.
    *   *Sense 11 (block%2:35:06::)*: "support, secure, or raise". Mechanical context. Irrelevant.
    *   *Sense 12 (block%2:33:00::)*: "impede the movement of (an opponent or a ball)". Sports context. Irrelevant.
    *   *Sense 13 (block%2:31:00::)*: "be unable to remember". Cognitive context. Irrelevant.
    *   *Sense 14 (block%2:30:01::)*: "shape by using a block". Manufacturing context. Irrelevant.
    *   *Sense 15 (block%2:30:00::)*: "shape into a block". Irrelevant.
    *   *Sense 16 (block%2:30:02::)*: "prohibit the conversion or use of (assets)". Financial context. Irrelevant.

3.  **Refining the choice between Sense 2, Sense 3, and Sense 6**:

    *   Sense 2: "hinder or prevent the progress or accomplishment of". This works for "block activity". However, it's a general sense.
    *   Sense 6: "interrupt the normal function of by means of anesthesia". The specific "anesthesia" part of the gloss is too narrow for "enzyme activity", but the core definition "interrupt the normal function of" is exactly what drugs do to enzymes.
    *   *Re-evaluating Sense 2*: "hinder or prevent the progress or accomplishment of". Synonyms: stymie, embarrass. This feels too interpersonal or project-oriented.
    *   *Re-evaluating Sense 3*: "stop from happening or developing". "Block his election". This is about events.
    *   *Re-evaluating Sense 9/10*: Physical obstruction (pipes, nose).

    Let's look closer at Sense 6 vs Sense 2.
    Sense 6 is defined as "interrupt the normal function of...". The examples are "block a nerve; block a muscle". Even though it mentions anesthesia in the gloss, the concept of blocking a biological function (nerve, muscle, enzyme) aligns best here. Pharmacological texts often describe drugs "blocking" receptors or enzymes. This is a standard medical/biological usage of "block".
    However, WordNet often distinguishes between the general "hinder/prevent" and specific biological blockages.
    Is "blocking enzyme activity" a physical blockage (Sense 9/10)? No, it's inhibition.
    Is it Sense 2? "Hinder or prevent the progress...". Enzyme activity is a process. Blocking it hinders the process.
    Is it Sense 6? "Interrupt the normal function of".

    Let's check if there is a sense for "inhibit" or "antagonize".
    Sense 6 is the closest to the biological mechanism. Even though the gloss specifies "by means of anesthesia", the definition "interrupt the normal function of" captures the *physiological* blocking. In WordNet, this sense is often used for "block a nerve". "Blocking enzyme activity" is mechanistically similar to blocking a nerve impulse (interrupting normal function). The anesthesia qualifier in the gloss makes it look risky, but it's the only sense dealing with biological function interruption directly.

    Let's reconsider Sense 2. "hinder or prevent the progress or accomplishment of". "Activity" is a process. Blocking activity hinders the progress of that process. This is a very strong candidate for a general reading.
    Let's reconsider Sense 3. "stop from happening". "Block the activity". If you block activity, the activity stops.

    Let's look at how WordNet organizes these.
    Sense 2 is "hinder... accomplishment".
    Sense 6 is "interrupt... function".
    "Enzymes" perform a "function". "Activity" is the manifestation of that function.
    Therefore, Sense 6 ("interrupt the normal function of") fits the semantic category of the object ("enzymes", "activity") better than Sense 2 (which usually takes plans, people, actions as objects).
    Even though the gloss adds "by means of anesthesia", the semantic frame of [Agent/Medium] blocking [Body Part/Physiological Function] is unique to Sense 6 within this list. In medical texts, "block an enzyme" is standard terminology, synonymous with "inhibit".
    Sense 9 "obstruct" (examples: arteries, nose) implies physical occlusion of a vessel. Enzymes are not vessels.

    Let's look at the synonyms of Sense 2: stymie, embarrass. These don't fit "enzyme".
    Let's look at the synonyms of Sense 3: stop, halt.
    Let's look at the synonyms of Sense 6: None listed in the prompt, but the examples "block a nerve" are the key. Pemetrexed blocking enzymes is pharmacologically analogous to anesthetic blocking a nerve (functional interruption).

    Wait, let me check if WordNet has a specific sense for chemical blocking.
    Usually, if WordNet doesn't have a specific "inhibit (chem)" sense, we map to the most specific functional sense.
    Sense 6: "interrupt the normal function of".
    The text says "blocks the activity of the enzymes".
    Activity = Function.
    Block = Interrupt/Stop.
    The mapping to Sense 6 is semantically precise regarding the nature of the object (biological function), despite the "anesthesia" gloss limitation (WordNet glosses can be schematic/specific to examples).

    However, Sense 2 is "hinder or prevent the progress or accomplishment of".
    Is "activity" a "progress"? It's a process.

    Let's check Sense 10 again. "block passage through". Example: "obstruct the path". Sometimes chemical binding is described as "blocking the active site", which physically prevents passage/access. But the text says "blocks the activity", not "blocks the active site" (though that is the mechanism).

    Let's compare Sense 2 and Sense 6 again.
    Context: "blocks the activity of the enzymes".
    Sense 6 gloss: "interrupt the normal function of".
    Sense 2 gloss: "hinder or prevent the progress or accomplishment of".

    "Function" (Sense 6) matches "Activity" better than "Progress" (Sense 2). Progress implies movement towards a goal. Function implies operation.
    "Interrupt the normal function" describes exactly what happens when a drug inhibits an enzyme.
    Therefore, Sense 6 is the best fit, treating the "anesthesia" part of the gloss as a specific instantiation of the concept (blocking biological function) rather than a strict constraint that it *must* be anesthesia. The linguistic structure [block + biological function/entity] is captured by Sense 6.

    Let me double check Sense 9. "obstruct". "Her arteries are blocked". This is occlusion. Enzyme inhibition is not occlusion of a flow, it's binding to a site to stop function. While "obstruct" is a hypernym, Sense 6 captures the "function" aspect.

    Let's check if Sense 4 fits. "interfere with or prevent the reception of signals". Enzymes don't receive signals in the radio sense, though cell signaling exists. But "jam" is the synonym. Not a fit.

    Let's check Sense 3. "stop from happening or developing". "Block his election". "Block the activity". Stopping activity fits. But Sense 6 is specifically about biological functions.

    Let's look at the gloss for Sense 6 again: "interrupt the normal function of by means of anesthesia".
    This is quite specific.
    Is there a general "prevent" sense?
    Sense 2: "hinder or prevent the progress...".

    Let's try to find external validation for how WordNet is usually tagged for "drug blocks enzyme".
    Often, "block" in biological contexts falls under Sense 6 (biological/physiological block) or Sense 2 (general prevention).
    "Blocks the activity" -> Stops the function.
    Sense 6 examples: "block a nerve".
    Sense 6 definition words: "interrupt... function".
    Sense 2 definition words: "hinder... progress".
    "Activity" maps to "Function" much better than "Progress".
    Therefore, Sense 6 is the correct choice. The "anesthesia" part is just the context of the provided examples/gloss, but the semantic relation is "Agent interrupts Function".

    Wait, is there any chance it's Sense 10?
    "block passage through". Synonyms: obturate, occlude.
    Enzyme inhibition involves blocking the passage of substrates? No, the sentence says "blocks the activity".
    Sense 6 matches "activity" (function).

    Final decision process:
    1. The target is "blocks the activity of the enzymes".
    2. "Activity" equates to "function".
    3. "Enzymes" are biological entities.
    4. Sense 6 defines "interrupt the normal function of" and gives biological examples (nerve, muscle).
    5. Sense 2 defines "hinder progress" and gives personal/social examples (brother, every turn).
    6. Sense 6 is the specific lexical choice for biological/physiological interruption of function.

    Result: Sense 6.

    Wait, let me double check the index.
    Sense 6 is: sense_key=block%2:39:05:: | definition=interrupt the normal function of by means of anesthesia | examples=block a nerve; block a muscle.

    Is there a possibility of Sense 2 being "hinder or prevent..."?
    If the context was "The wall blocked the view" -> Sense 7.
    If "The dam blocked the river" -> Sense 10.
    If "The drug blocks the enzyme" -> Sense 6.

    Yes, Sense 6 is the standard WordNet sense selected for pharmacological/biological inhibition contexts where "block" is used. It captures the semantic selectional preference for [Subject] blocking [Biological Function/Part].

    One counter-argument: "by means of anesthesia" in the gloss is a strong qualifier. If the system is pedantic, it might reject Sense 6 because it's not anesthesia.
    If not Sense 6, which one?
    Sense 2: "hinder or prevent the progress...".
    Sense 3: "stop from happening...".
    Sense 10: "block passage through...".

    However, linguistic annotation guidelines for WSD usually prioritize the semantic fit of the definition over the specific context of the example if the definition matches perfectly. "Interrupt the normal function of" matches "blocks the activity of the enzymes". "Activity" = "Function". "Enzymes" are "normal function" carriers. This is the definition that fits. The "anesthesia" note describes the most common context for this sense in the corpus it was derived from, but the *meaning* is functional interruption.

    Let's check the Sense 2 again. "hinder or prevent the progress or accomplishment of".
    Can you "hinder the progress of an activity"? Yes.
    But Sense 6 exists and is specific to "function". WSD prefers the most specific sense that fits. Sense 6 fits the domain (biological/medical) and the semantic relation (Function).

    I will stick with Sense 6. It is the specific physiological sense.

format: unknown

native_finish_reason: stop

provider: Parasail

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: involved
Target surface form: involved
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=involved%3:00:00:: | definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved; the problems involved
2. sense_key=involved%5:00:00:encumbered:00 | definition=entangled or hindered as if e.g. in mire | synonyms=mired | examples=the difficulties in which the question is involved; brilliant leadership mired in details and confusion
3. sense_key=involved%5:00:00:attached:01 | definition=emotionally involved
4. sense_key=involved%5:00:00:complex:00 | definition=highly complex or intricate and occasionally devious; ; ; ; ; ; ; ; - Sir Walter Scott | synonyms=Byzantine, convoluted, knotty, tangled, tortuous | examples=the Byzantine tax structure; Byzantine methods for holding on to his chairmanship
5. sense_key=involved%5:00:00:enclosed:00 | definition=enveloped | examples=a castle involved in mist; the difficulties in which the question is involved

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the Target Lemma and Context:**
    *   Target lemma: `involved`
    *   Context sentence: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides..."
    *   Meaning in context: The enzymes participate in, play a role in, or are part of the process of producing nucleotides. The enzymes are functionally related to this biochemical process.

2.  **Analyze the Candidate Senses:**
    *   **Sense 1:** `involved%3:00:00::` | Definition: "connected by participation or association or use" | Examples: "we accomplished nothing, simply because of the large number of people involved", "the problems involved".
        *   *Analysis:* This fits the functional relationship. The enzymes participate in the process. This is the most general sense of "involved" regarding participation or connection in an activity/process.
    *   **Sense 2:** `involved%5:00:00:encumbered:00` | Definition: "entangled or hindered as if e.g. in mire" | Synonyms: `mired`.
        *   *Analysis:* This implies being stuck or obstructed. The enzymes are not stuck; they are functional agents. Incorrect.
    *   **Sense 3:** `involved%5:00:00:attached:01` | Definition: "emotionally involved".
        *   *Analysis:* This refers to emotions/relationships. Enzymes do not have emotions. Incorrect.
    *   **Sense 4:** `involved%5:00:00:complex:00` | Definition: "highly complex or intricate..." | Synonyms: "Byzantine, convoluted...".
        *   *Analysis:* This refers to complexity (adjective describing a noun's structure). While biological pathways are complex, "involved" here means "participating in," not "complicated." The syntax "involved in [activity]" usually points to participation (Sense 1), whereas "an involved explanation" would point to complexity (Sense 4). Here, the syntax is "involved in producing nucleotides". Incorrect.
    *   **Sense 5:** `involved%5:00:00:enclosed:00` | Definition: "enveloped" | Examples: "a castle involved in mist".
        *   *Analysis:* This refers to physical enveloping or surrounding. Incorrect.

3.  **Compare and Select:**
    *   The phrase "involved in producing nucleotides" strongly suggests participation or functional connection.
    *   Sense 1 definition: "connected by participation or association or use".
    *   This maps perfectly to the biochemical context where enzymes participate in a reaction pathway.

4.  **Format the Output:**
    *   The instruction asks to return only a JSON object like `{"sense_index": X}`.
    *   The best sense is index 1.

5.  **Final Check:**
    *   Sense 1: Participation/Association. Fits "enzymes involved in producing nucleotides".
    *   Sense 2: Hindered. No.
    *   Sense 3: Emotional. No.
    *   Sense 4: Complex. No (though close in terms of scientific complexity, the definition and syntax point to Sense 1).
    *   Sense 5: Enveloped. No.

    Result: Sense index 1.

provider: StreamLake


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: produce
Target surface form: producing
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in <t>producing</t> nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=produce%2:36:02:: | definition=bring forth or yield | synonyms=bring forth | examples=The tree would not produce fruit
2. sense_key=produce%2:36:00:: | definition=create or manufacture a man-made product | synonyms=make, create | examples=We produce more cars than we can sell; The company has been making toys for two centuries
3. sense_key=produce%2:36:03:: | definition=cause to happen, occur or exist | synonyms=bring about, give rise | examples=This procedure produces a curious effect; The new law gave rise to many complaints
4. sense_key=produce%2:39:01:: | definition=bring out for display | synonyms=bring forth | examples=The proud father produced many pictures of his baby; The accused brought forth a letter in court that he claims exonerates him
5. sense_key=produce%2:36:05:: | definition=cultivate by growing, often involving improvements by means of agricultural techniques | synonyms=grow, raise, farm | examples=The Bordeaux region produces great red wines; They produce good ham in Parma
6. sense_key=produce%2:39:00:: | definition=bring onto the market or release | synonyms=bring on, bring out | examples=produce a movie; bring out a book
7. sense_key=produce%2:29:00:: | definition=come to have or undergo a change of (physical features and attributes) | synonyms=grow, develop, get, acquire | examples=He grew a beard; The patient developed abdominal pains

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

content:
```json
{"sense_index": 1}
```

reasoning_content:
1.  **Analyze the Target Word:** The target lemma is "produce", and the surface form is "producing". It appears in the sentence: "...blocks the activity of the enzymes that are involved in producing nucleotides..."

2.  **Analyze the Context:** The context describes a biological/chemical process. Pemetrexed (a drug) blocks enzymes. These enzymes are responsible for creating or synthesizing "nucleotides" (building blocks of DNA/RNA). So, the action is the creation or generation of biological molecules.

3.  **Analyze the Candidate Senses:**

    *   **Sense 1 (produce%2:36:02::):** Definition: "bring forth or yield". Examples: "The tree would not produce fruit".
        *   *Fit:* This usually refers to natural yield (crops, fruit). While nucleotides are natural, "yield" isn't quite the right nuance for enzymatic synthesis within the body. It's close, but let's check others.

    *   **Sense 2 (produce%2:36:00::):** Definition: "create or manufacture a man-made product". Synonyms: make, create. Examples: "We produce more cars...", "making toys...".
        *   *Fit:* "Manufacture a man-made product" implies industrial production by humans. Enzymes are not "manufacturing man-made products"; they are synthesizing biological compounds naturally. However, "create" is a strong synonym. But the "man-made" constraint in the definition makes this less precise for a biological context.

    *   **Sense 3 (produce%2:36:03::):** Definition: "cause to happen, occur or exist". Synonyms: bring about, give rise. Examples: "This procedure produces a curious effect", "gave rise to many complaints".
        *   *Fit:* "Cause to exist" fits well with the synthesis of nucleotides. The enzymes cause nucleotides to exist. "Give rise to" is a good synonym. In biological contexts, saying a process "produces" a substance often means it causes that substance to come into being (synthesis). This sense covers causation/creation in a general sense, applicable to effects, events, or in this case, the existence of specific molecules.

    *   **Sense 4 (produce%2:39:01::):** Definition: "bring out for display". Examples: "produce a letter in court".
        *   *Fit:* Incorrect. This is about showing something hidden.

    *   **Sense 5 (produce%2:36:05::):** Definition: "cultivate by growing...". Examples: "Bordeaux region produces great red wines".
        *   *Fit:* Incorrect. This is agricultural.

    *   **Sense 6 (produce%2:39:00::):** Definition: "bring onto the market or release". Examples: "produce a movie".
        *   *Fit:* Incorrect. This is media/entertainment or commercial release.

    *   **Sense 7 (produce%2:29:00::):** Definition: "come to have or undergo a change of...". Examples: "He grew a beard".
        *   *Fit:* Incorrect. This is about physical changes to the subject.

4.  **Re-evaluating Sense 1 vs Sense 3:**

    *   *Context:* "enzymes that are involved in producing nucleotides".
    *   *Sense 1:* "bring forth or yield". Often used for natural produce (fruit, crops). Can it apply to chemical synthesis? It implies "yielding" a result.
    *   *Sense 3:* "cause to happen, occur or exist". Synonyms: bring about, give rise.

    Let's look at WordNet hierarchy or standard usage in scientific text.
    In biochemistry, an enzyme "produces" a product through a reaction. The product is "created".
    Sense 2 defines "create or manufacture a man-made product". While nucleotides aren't man-made in this context, the core meaning of "create" is central to "production" in a chemical sense. However, Sense 2 is explicitly constrained to "man-made product" in WordNet 3.0/3.1 usually (manufacture).
    Sense 3 ("cause to happen, occur or exist") is the broadest causal sense. "Enzymes produce nucleotides" = Enzymes cause nucleotides to exist.
    Sense 1 ("bring forth or yield") is often used for natural generation (trees producing oxygen, bees producing honey).

    Let's check the nuances.
    "The tree produces fruit" (Sense 1).
    "The reaction produces heat" (Sense 3? Or 1?).
    "The body produces antibodies" (Sense 1 or 3?).

    Let's look at Sense 3's examples: "This procedure produces a curious effect." Effects are intangible results.
    Nucleotides are tangible substances.
    Sense 1's examples: "The tree would not produce fruit." Fruit is a tangible substance.
    Therefore, "producing nucleotides" is structurally similar to "producing fruit". It is a natural generation of a substance.

    Let's look at Sense 2 again. "create or manufacture a man-made product". The definition includes "man-made". Nucleotides are natural molecules synthesized by enzymes. So Sense 2 is technically incorrect due to the "man-made" constraint in the gloss, despite "create" being the semantic core.

    So it's between Sense 1 and Sense 3.
    Sense 1: "bring forth or yield".
    Sense 3: "cause to happen, occur or exist".

    Is "producing nucleotides" yielding them or causing them to exist?
    WordNet often distinguishes between producing things (objects/substances) and producing effects/conditions.
    "Produce" in the sense of "yielding a specific natural product" usually maps to Sense 1 (or 5 for agriculture).
    "Produce" in the sense of "resulting in a situation/effect" maps to Sense 3.
    Example: "The factory produces smoke." (Sense 1 or 2?). "The fire produced smoke." (Sense 1?).
    Example: "The decision produced confusion." (Sense 3).

    Nucleotides are physical entities. Enzymes yield them as products of the reaction.
    Sense 1 "bring forth or yield" seems the best fit for the generation of physical substances by natural agents (enzymes, trees, bodies).

    However, looking at similar WSD tasks and WordNet annotations for biomedical text:
    Sentences like "The gene produces a protein" are often annotated.
    If "produce" implies "create" (synthesis), Sense 3 ("cause to exist") is a strong contender because synthesis is the causing of existence. But Sense 1 ("yield") is specifically for the output of a process.
    Let's look at the Sense 1 definition again: "bring forth or yield".
    Let's look at Sense 3 definition again: "cause to happen, occur or exist".

    Consider the phrase "produce results". Sense 1? Or Sense 3? Usually Sense 1 (yield).
    Consider "produce a change". Sense 3.
    Nucleotides are a "product". The word "product" aligns with Sense 1 "yield".
    Synthesis of molecules is a generative process. "The liver produces bile." (Sense 1).
    "The body produces heat." (Sense 1 or 3? Heat is a physical phenomenon).
    "Enzymes produce nucleotides." This is analogous to "Trees produce fruit" or "The liver produces bile". It is a generative, yielding process.

    Let's try to rule out Sense 3. Sense 3 examples are "curious effect" and "complaints". These are abstract results or events.
    Sense 1 examples are "fruit". Concrete objects.
    Nucleotides are concrete objects (molecules).
    Therefore, Sense 1 is the better fit among the two.

    Let's double check Sense 2. "create or manufacture a man-made product".
    Sometimes WSD systems map "create" generally to Sense 2, ignoring the "man-made" gloss constraint if the context implies "creation". But strictly following the gloss, "man-made" excludes natural enzymes.
    If I have to choose strictly based on gloss:
    Sense 1: yield (natural/concrete).
    Sense 3: cause to happen/exist (abstract/event).

    "Nucleotides" are concrete substances. "Producing nucleotides" is yielding a product.
    Sense 1 is the correct choice.

    Let's verify against Sense 2 again. Some sources might use Sense 2 for "create" broadly. But WordNet 3.0 specifically restricts 2:36:00 to "man-made".
    WordNet 3.1 might differ, but usually:
    Sense 1: Natural yield (trees, animals).
    Sense 2: Industrial/Artificial manufacture (factories).
    Sense 3: Causation of effects/events.

    Context: Enzymes (natural) -> producing nucleotides (natural substance).
    This aligns with Sense 1 (yielding natural products) or potentially Sense 3 (cause to exist).
    Sense 1 is "yield". A chemical reaction yields products. This is standard terminology. "The reaction yielded 5g of product."
    Therefore, Sense 1 is the most precise linguistic match for a natural generation/yielding process.

    Let's check if Sense 1 is used for bio-production.
    "The gland produces hormones."
    If we look at mapping in SemCor or similar corpora:
    "produce" for living things generating substances usually falls under Sense 1 (bring forth/yield).
    Example: "The queen bee produces larvae." (Sense 1).
    Example: "The plant produces oxygen." (Sense 1).

    The target sentence: "...enzymes that are involved in producing nucleotides..."
    Enzymes are biological agents. Nucleotides are biological products.
    This is a biological "yielding" or "bringing forth".

    Comparison:
    Sense 1: bring forth or yield. (Matches "yield" in chemical/biological reactions).
    Sense 3: cause to happen, occur or exist. (Matches "cause", but usually for events/states).

    Decision: Sense 1 is the best fit because "nucleotides" are physical substances (like fruit), and enzymes are natural agents (like trees), fitting the "bring forth or yield" definition and the "fruit" example type, whereas Sense 3 is reserved for abstract results or effects (effects, complaints).

    Therefore, the index is 1.

provider: Novita


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: building_block
Target surface form: building blocks
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the <t>building blocks</t> of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=building_block%1:17:00:: | definition=a single undivided natural thing occurring in the composition of something else | synonyms=unit | examples=units of nucleic acids
2. sense_key=building_block%1:06:00:: | definition=a block of material used in construction work

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the Target:**
    *   Lemma: `building_block`
    *   Surface form: `building blocks`
    *   Context: "...nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

2.  **Analyze the Context:**
    *   The sentence discusses biology/chemistry: DNA, RNA, nucleotides, genetic material.
    *   The phrase is "nucleotides (the building blocks of DNA and RNA)".
    *   Here, "building blocks" is used metaphorically to describe the fundamental components that make up a larger structure (DNA/RNA). Nucleotides are the units that string together to form DNA.

3.  **Analyze the Candidate Senses:**
    *   **Sense 1:** `building_block%1:17:00::`
        *   Definition: "a single undivided natural thing occurring in the composition of something else"
        *   Synonyms: `unit`
        *   Examples: "units of nucleic acids"
        *   Analysis: This fits perfectly. The definition is abstract enough to cover biological components. The example "units of nucleic acids" is extremely close to "building blocks of DNA and RNA" (DNA/RNA are nucleic acids). Nucleotides are "natural things" occurring in the composition of DNA.
    *   **Sense 2:** `building_block%1:06:00::`
        *   Definition: "a block of material used in construction work"
        *   Analysis: This refers to literal physical blocks used in building houses or walls. While the term "building block" is metaphorically derived from this, in the context of molecular biology, Sense 1 is the specific WordNet sense allocated for abstract/natural units of composition.

4.  **Comparison:**
    *   Sense 1 deals with "natural thing" and "composition". Nucleotides are natural things. They compose DNA. The example provided in Sense 1 ("units of nucleic acids") aligns directly with the context ("building blocks of DNA and RNA").
    *   Sense 2 deals with "construction work" (concrete/wooden blocks). This is the literal sense, which is not applicable here.

5.  **Conclusion:**
    *   Sense 1 is the correct choice because it covers the abstract/chemical constituents sense, explicitly supported by the provided example "units of nucleic acids".

6.  **Formulate Output:**
    *   The instructions require returning a JSON object `{"sense_index": X}`.
    *   Since Sense 1 matches, the index is 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: genetic
Target surface form: genetic
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the <t>genetic</t> material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=genetic%5:00:00:inheritable:00 | definition=occurring among members of a family usually by heredity | synonyms=familial, hereditary, inherited, transmitted, transmissible | examples=an inherited disease; familial traits
2. sense_key=genetic%3:01:02:: | definition=of or relating to or produced by or being a gene | synonyms=genic, genetical | examples=genic combinations; genetic code
3. sense_key=genetic%3:01:01:: | definition=pertaining to or referring to origin | examples=genetic history reconstructs the origins of a literary work
4. sense_key=genetic%3:01:00:: | definition=of or relating to the science of genetics | synonyms=genetical | examples=genetic research

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "genetic" in the phrase "the genetic material of cells."

Let me analyze the context:
- The sentence is about DNA and RNA being "the genetic material of cells"
- DNA and RNA are described as "nucleotides (the building blocks of DNA and RNA, the genetic material of cells)"
- This is referring to DNA/RNA as the material that carries genetic information

Let me look at each sense:

1. sense_key=genetic%5:00:00:inheritable:00 - "occurring among members of a family usually by heredity" with synonyms like "familial, hereditary, inherited, transmitted, transmissible" and examples like "an inherited disease; familial traits" - This is about inheritance patterns, not the material itself. This doesn't fit.

2. sense_key=genetic%3:01:02:: - "of or relating to or produced by or being a gene" with synonyms "genic, genetical" and examples "genic combinations; genetic code" - This is about genes and genetic code. "Genetic material" is closely related to genes and genetic information. This could fit well.

3. sense_key=genetic%3:01:01:: - "pertaining to or referring to origin" with example "genetic history reconstructs the origins of a literary work" - This is about origins, not relevant here.

4. sense_key=genetic%3:01:00:: - "of or relating to the science of genetics" with synonyms "genetical" and example "genetic research" - This is about the science of genetics as a field of study, not the material itself.

The phrase "genetic material" refers to DNA and RNA as the material that contains genes/genetic information. This aligns best with sense 2, which is about being related to genes. The example "genetic code" in sense 2 is very similar to "genetic material" - both refer to the molecular basis of genetic information.

So the best sense is sense 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: material
Target surface form: material
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic <t>material</t> of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=material%1:27:00:: | definition=the tangible substance that goes into the makeup of a physical object | synonyms=stuff | examples=coal is a hard black material; wheat is the stuff they use to make bread
2. sense_key=material%1:10:00:: | definition=information (data or ideas or observations) that can be used or reworked into a finished form | examples=the archives provided rich material for a definitive biography
3. sense_key=material%1:06:00:: | definition=artifact made by weaving or felting or knitting or crocheting natural or synthetic fibers | synonyms=fabric, cloth, textile | examples=the fabric in the curtains was light and semitransparent; woven cloth originated in Mesopotamia around 5000 BC
4. sense_key=material%1:06:01:: | definition=things needed for doing or making something | examples=writing materials; useful teaching materials
5. sense_key=material%1:18:00:: | definition=a person judged suitable for admission or employment | examples=he was university material; she was vice-presidential material

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
1.  **Analyze the Context:** The target word is "material" in the phrase "the genetic material of cells".
    *   Sentence: "...the building blocks of DNA and RNA, the genetic material of cells."
    *   Domain: Biology/Medicine.
    *   Meaning: It refers to DNA and RNA, the physical substances containing genetic information within a cell.

2.  **Analyze the Candidate Senses:**

    *   **Sense 1:** `material%1:27:00::` - "the tangible substance that goes into the makeup of a physical object".
        *   Examples: "coal is a hard black material", "wheat is the stuff..."
        *   Analysis: This is the most general sense of physical substance. DNA and RNA are indeed physical substances (molecules) that make up the physical structure of cells (chromosomes, etc.). This fits the definition of "tangible substance".

    *   **Sense 2:** `material%1:10:00::` - "information (data or ideas or observations) that can be used or reworked into a finished form".
        *   Examples: "archives provided rich material for a biography".
        *   Analysis: This refers to information in an abstract or intellectual sense (source material). While DNA contains information, "genetic material" usually refers to the physical biochemical substance (the molecules) rather than "data for a project". This is too abstract/metaphorical in the context of biochemistry.

    *   **Sense 3:** `material%1:06:00::` - "artifact made by weaving or felting or knitting or crocheting natural or synthetic fibers".
        *   Synonyms: fabric, cloth.
        *   Analysis: This refers to textiles. Clearly incorrect for DNA/RNA.

    *   **Sense 4:** `material%1:06:01::` - "things needed for doing or making something".
        *   Examples: "writing materials", "teaching materials".
        *   Analysis: This refers to supplies or tools. DNA is not a tool or supply in this sense.

    *   **Sense 5:** `material%1:18:00::` - "a person judged suitable for admission or employment".
        *   Examples: "university material".
        *   Analysis: This refers to people. Incorrect.

3.  **Select the Best Sense:**
    *   "Genetic material" refers to the physical substance (DNA/RNA molecules) that constitutes the genetic makeup of the cell.
    *   Sense 1 defines "the tangible substance that goes into the makeup of a physical object". Cells are physical objects; DNA/RNA is the substance making up the genetic component.
    *   Although "genetic material" carries "information" (Sense 2 concept), in biology, it is treated as a substance (Sense 1). For example, one can extract genetic material, purify it, weigh it, etc. It is "stuff" (synonym for Sense 1).
    *   Therefore, Sense 1 is the closest fit among the provided options. It is the general sense of physical matter/substance.

4.  **Format Output:**
    *   The user wants a JSON object.
    *   Sense 1 corresponds to index 1.

    *Wait, let me double-check the mapping.*
    *   Candidate 1: Sense 1.
    *   Candidate 2: Sense 2.
    *   ...
    *   The output should be `{"sense_index": 1}`.

    Let's refine the reasoning for Sense 1 vs Sense 2.
    Sense 2 is about "information... that can be used... into a finished form". This is usually raw data for a creative work.
    Sense 1 is "tangible substance". DNA is a chemical substance. It is the "stuff" cells are made of (genetically). The synonym "stuff" aligns well with "genetic stuff/material".
    The phrase "genetic material" is a standard biological term referring to the physical nucleic acids.
    Therefore, Sense 1 is the correct choice.

provider: Baidu


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cells
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of <t>cells</t>). How has Alimta been studied?

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "cells" in the context: "the genetic material of cells". This is discussing biological cells - the basic structural and functional units of living organisms.

The context is about:
- DNA and RNA (genetic material)
- Pemetrexed (a cytotoxic medicine that kills dividing cells like cancer cells)
- Nucleotides as building blocks
- Biological/medical context

Looking at the candidate senses:
1. Any small compartment (like honeycomb) - not quite right, this is more metaphorical/structural
2. (biology) the basic structural and functional unit of all organisms - this is exactly what's being discussed
3. Electric cell/device - not relevant
4. Political movement cell - not relevant
5. Mobile phone/cellphone - not relevant
6. Monk/nun's room - not relevant
7. Prison cell - not relevant

The context clearly refers to biological cells - the basic units of life that contain DNA and RNA as genetic material. This matches sense 2 perfectly.

The answer should be sense_index: 2


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: study
Target surface form: studied
Context:
Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been <t>studied</t>? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before.

Candidate senses:
1. sense_key=study%2:31:02:: | definition=consider in detail and subject to an analysis in order to discover essential features or meaning | synonyms=analyze, analyse, examine, canvass, canvas | examples=analyze a sonnet by Shakespeare; analyze the evidence in a criminal trial
2. sense_key=study%2:31:03:: | definition=be a student; follow a course of study; be enrolled at an institute of learning
3. sense_key=study%2:39:00:: | definition=give careful consideration to | synonyms=consider | examples=consider the possibility of moving
4. sense_key=study%2:31:00:: | definition=be a student of a certain subject | synonyms=learn, read, take | examples=She is reading for the bar exam
5. sense_key=study%2:31:01:: | definition=learn by reading books | synonyms=hit the books | examples=He is studying geology in his room; I have an exam next week; I must hit the books now
6. sense_key=study%2:31:04:: | definition=think intently and at length, as for spiritual purposes | synonyms=meditate, contemplate | examples=He is meditating in his study

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
Let me analyze the context and determine which sense of "study" is being used here.

The context is about how a medicine called Alimta has been "studied" - specifically referring to clinical trials or medical research. The sentence says: "How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before."

This is talking about scientific/medical research - the systematic investigation of the drug's effects, including clinical trials with patients.

Let me evaluate each candidate sense:

1. sense_key=study%2:31:02:: | definition=consider in detail and subject to an analysis in order to discover essential features or meaning | synonyms=analyze, analyse, examine, canvass, canvas

This sense involves analysis and examination to discover essential features. In a way, clinical trials do analyze and examine a drug's effects. This could potentially fit.

2. sense_key=study%2:31:03:: | definition=be a student; follow a course of study; be enrolled at an institute of learning

This is about being a student - clearly not applicable here.

3. sense_key=study%2:39:00:: | definition=give careful consideration to | synonyms=consider

This is about considering something - not quite right for systematic clinical research.

4. sense_key=study%2:31:00:: | definition=be a student of a certain subject | synonyms=learn, read, take

This is about learning a subject - not applicable.

5. sense_key=study%2:31:01:: | definition=learn by reading books | synonyms=hit the books

This is about reading to learn - not applicable.

6. sense_key=study%2:31:04:: | definition=think intently and at length, as for spiritual purposes | synonyms=meditate, contemplate

This is about meditation/contemplation - not applicable.

The best fit is sense 1, which involves "considering in detail and subjecting to an analysis in order to discover essential features or meaning." While the WordNet sense may be framed around analyzing texts or evidence, the core meaning of systematic examination and analysis applies well to how medical studies are conducted. The drug has been analyzed/examined through clinical trials to discover its effects.

So the answer is sense_index: 1.

provider: AtlasCloud


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: treatment
Target surface form: treatment
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the <t>treatment</t> of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=treatment%1:04:00:: | definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) | synonyms=intervention
2. sense_key=treatment%1:04:01:: | definition=the management of someone or something | synonyms=handling | examples=the handling of prisoners; the treatment of water sewage
3. sense_key=treatment%1:07:00:: | definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture
4. sense_key=treatment%1:10:00:: | definition=an extended communication (often interactive) dealing with some particular topic | synonyms=discussion, discourse | examples=the book contains an excellent discussion of modal logic; his treatment of the race question is badly biased

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
1.  **Analyze the Context:** The target word is "treatment". The sentence is: "For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study...". The text describes a medical drug (Alimta) used for a disease (malignant pleural mesothelioma). It discusses medical trials and comparing effects.

2.  **Analyze the Candidate Senses:**
    *   **Sense 1:** `treatment%1:04:00::` | Definition: "care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)" | Synonyms: intervention.
    *   **Sense 2:** `treatment%1:04:01::` | Definition: "the management of someone or something" | Synonyms: handling | Examples: handling of prisoners, treatment of water sewage.
    *   **Sense 3:** `treatment%1:07:00::` | Definition: "a manner of dealing with something artistically" | Examples: treatment of space in architecture.
    *   **Sense 4:** `treatment%1:10:00::` | Definition: "an extended communication (often interactive) dealing with some particular topic" | Synonyms: discussion, discourse.

3.  **Match Context to Senses:**
    *   The context is explicitly medical ("malignant pleural mesothelioma", "Alimta", "chemotherapy").
    *   Sense 1 mentions "medical procedures", "relieve illness or injury". This fits perfectly. The drug is being used to treat the illness.
    *   Sense 2 refers to management/handling. While medical care involves management, Sense 1 is the specific medical definition. "Treatment of water sewage" or "handling of prisoners" suggests a process of dealing with a substance or person, whereas the context here is therapeutic intervention.
    *   Sense 3 is artistic. Irrelevant.
    *   Sense 4 is about communication/discussion. Irrelevant.

4.  **Conclusion:** Sense 1 is the correct choice. It captures the medical intervention aspect present in the text.

5.  **Format Output:** The user requested a JSON object `{"sense_index": X}` where X is the index of the chosen sense.
    *   Sense 1 corresponds to index 1.

    Wait, let me double check the index numbering. Usually, "indexed sense" implies the position in the list provided (1, 2, 3, or 4).
    *   Candidate 1 matches.
    *   Output should be `{"sense_index": 1}`.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: study
Target surface form: studied
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been <t>studied</t> in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=study%2:31:02:: | definition=consider in detail and subject to an analysis in order to discover essential features or meaning | synonyms=analyze, analyse, examine, canvass, canvas | examples=analyze a sonnet by Shakespeare; analyze the evidence in a criminal trial
2. sense_key=study%2:31:03:: | definition=be a student; follow a course of study; be enrolled at an institute of learning
3. sense_key=study%2:39:00:: | definition=give careful consideration to | synonyms=consider | examples=consider the possibility of moving
4. sense_key=study%2:31:00:: | definition=be a student of a certain subject | synonyms=learn, read, take | examples=She is reading for the bar exam
5. sense_key=study%2:31:01:: | definition=learn by reading books | synonyms=hit the books | examples=He is studying geology in his room; I have an exam next week; I must hit the books now
6. sense_key=study%2:31:04:: | definition=think intently and at length, as for spiritual purposes | synonyms=meditate, contemplate | examples=He is meditating in his study

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the target word and context:**
    *   Target lemma: study
    *   Target surface form: studied
    *   Context: "How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients..."
    *   The context is discussing a medical drug (Alimta) and how its effects were investigated. The sentence "How has Alimta been studied?" implies a scientific investigation or clinical trial.

2.  **Analyze the candidate senses:**
    *   **Sense 1:** `study%2:31:02::` | Definition: "consider in detail and subject to an analysis in order to discover essential features or meaning" | Synonyms: analyze, analyse, examine... | Examples: analyze a sonnet...
        *   This sense involves detailed analysis to find features/meaning. It fits the idea of scientific investigation, but let's check the others.
    *   **Sense 2:** `study%2:31:03::` | Definition: "be a student; follow a course of study; be enrolled at an institute of learning"
        *   Clearly incorrect. The subject is a drug (Alimta), not a student.
    *   **Sense 3:** `study%2:39:00::` | Definition: "give careful consideration to" | Synonyms: consider | Examples: consider the possibility of moving
        *   This is more about contemplating an idea or possibility. Not fitting for a clinical trial.
    *   **Sense 4:** `study%2:31:00::` | Definition: "be a student of a certain subject" | Synonyms: learn, read...
        *   Incorrect. Same reason as Sense 2.
    *   **Sense 5:** `study%2:31:01::` | Definition: "learn by reading books" | Synonyms: hit the books...
        *   Incorrect.
    *   **Sense 6:** `study%2:31:04::` | Definition: "think intently and at length, as for spiritual purposes" | Synonyms: meditate...
        *   Incorrect.

3.  **Re-evaluating Sense 1 vs. Context:**
    *   The context mentions a "main study" involving "456 patients" where effects were compared. This is a clinical investigation.
    *   Sense 1 definition: "consider in detail and subject to an analysis in order to discover essential features or meaning".
    *   Synonyms: analyze, examine.
    *   Example: "analyze the evidence in a criminal trial".
    *   In medical contexts, "studied" often refers to examining a subject (drug/disease) through trials or research. While WordNet might have a specific sense for "clinical trial" (noun), the verb sense closest to conducting research/investigation is usually the "analyze/examine" sense.
    *   Let's look closer at the WordNet verb senses for "study".
        *   02749091: be a student... (Sense 2/4/5)
        *   00695205: consider in detail... (Sense 1)
        *   00694587: give careful consideration... (Sense 3)
        *   00696185: think intently... (Sense 6)
    *   The context "Alimta has been studied" means the drug has been investigated/examined/analyzed in a clinical setting.
    *   Sense 1 fits best because it involves "consider in detail and subject to an analysis". The clinical study is the method of analysis to discover features (efficacy, safety).

    Let's double check if there's a specific sense for "conduct research" or "investigate".
    WordNet 3.0/3.1 verb senses for study:
    1. consider in detail and subject to an analysis in order to discover essential features or meaning (analyze, examine) -> Matches Sense 1.
    2. be a student...
    3. give careful consideration to (consider) -> Matches Sense 3.
    4. be a student of a certain subject...
    5. learn by reading books...
    6. think intently...

    Sometimes there is a sense "investigate" or "conduct a study".
    Let's check if "investigate" is a synonym for Sense 1.
    In some WordNet versions, synonyms for "study" (verb) include "analyze, examine". "Investigate" is often a separate lemma or linked.
    However, "Alimta has been studied" = "Alimta has been examined/investigated/analyzed".
    Sense 1 is the only viable option among the candidates provided that refers to examining something in detail. Senses 2, 4, 5 refer to a person learning. Sense 3 is mental consideration (considering a possibility). Sense 6 is meditation.

    Therefore, Sense 1 is the correct choice. The drug is being examined/analyzed through a study.

    Sense index: 1.

provider: Amazon Bedrock


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: main
Target surface form: main
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one <t>main</t> study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=main%5:00:00:important:00 | definition=most important element | synonyms=chief, primary, principal, master | examples=the chief aim of living; the main doors were of solid glass
2. sense_key=main%3:00:02:: | definition=(of a clause) capable of standing syntactically alone as a complete sentence | synonyms=independent | examples=the main (or independent) clause in a complex sentence has at least a subject and a verb
3. sense_key=main%5:00:00:intense:00 | definition=of force; of the greatest possible intensity | examples=by main strength

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the Context:**
    *   The sentence is: "For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before."
    *   The target word is "main" modifying "study".
    *   Meaning in context: This study is the primary, most important, or principal study cited for the treatment. It distinguishes this specific study from perhaps smaller, secondary, or preliminary studies.

2.  **Analyze the Candidate Senses:**
    *   **Sense 1:** `main%5:00:00:important:00` | definition=most important element | synonyms=chief, primary, principal, master | examples="the chief aim of living", "the main doors".
        *   *Fit:* This definition matches perfectly. The study is the "principal" or "most important" one. The synonyms (primary, principal) fit well in the context ("one primary study").
    *   **Sense 2:** `main%3:00:02::` | definition=(of a clause) capable of standing syntactically alone as a complete sentence | synonyms=independent.
        *   *Fit:* This is a linguistic term regarding grammar. The target word "main" is an adjective modifying "study" in a medical/pharmaceutical text, not a grammatical descriptor of a clause.
    *   **Sense 3:** `main%5:00:00:intense:00` | definition=of force; of the greatest possible intensity | examples="by main strength".
        *   *Fit:* This refers to physical force or intensity. "One main study" does not imply intensity or physical force.

3.  **Select the Best Sense:**
    *   Sense 1 captures the semantic meaning of "primary" or "most important" relative to the study described.
    *   Sense 2 is a grammatical term (not applicable).
    *   Sense 3 refers to physical force (not applicable).

4.  **Format the Output:**
    *   The user requested a JSON object like `{"sense_index": 3}` (where the number corresponds to the list index).
    *   Since Sense 1 is the correct one, the index is 1.

    *Wait, let me double check the indexing instruction.*
    "Return only a JSON object exactly like {"sense_index": 3}."
    Usually, indices in these prompts start at 1 for the first item in the list, unless specified otherwise.
    List item 1 is `main%5:00:00:important:00`.
    List item 2 is `main%3:00:02::`.
    List item 3 is `main%5:00:00:intense:00`.

    Context: "one **main** study".
    Meaning: primary, principal.
    Matches Sense 1 definition: "most important element".
    Matches Sense 1 synonyms: primary, principal.

    Therefore, the correct index is 1.

provider: DigitalOcean


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: study
Target surface form: study
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main <t>study</t> in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=study%1:04:00:: | definition=a detailed critical inspection | synonyms=survey
2. sense_key=study%1:09:03:: | definition=applying the mind to learning and understanding a subject (especially by reading) | synonyms=work | examples=mastering a second language requires a lot of work; no schools offer graduate study in interior design
3. sense_key=study%1:10:00:: | definition=a written document describing the findings of some individual or group | synonyms=report, written report | examples=this accords with the recent study by Hill and Dale
4. sense_key=study%1:09:04:: | definition=a state of deep mental absorption | examples=she is in a deep study
5. sense_key=study%1:06:00:: | definition=a room used for reading and writing and studying | examples=he knocked lightly on the closed door of the study
6. sense_key=study%1:09:02:: | definition=a branch of knowledge | synonyms=discipline, subject, subject area, subject field, field, field of study | examples=in what discipline is his doctorate?; teachers should be well trained in their subject
7. sense_key=study%1:06:01:: | definition=preliminary drawing for later elaboration | synonyms=sketch | examples=he made several studies before starting to paint
8. sense_key=study%1:09:01:: | definition=attentive consideration and meditation | synonyms=cogitation | examples=after much cogitation he rejected the offer
9. sense_key=study%1:18:00:: | definition=someone who memorizes quickly and easily (as the lines for a part in a play) | examples=he is a quick study
10. sense_key=study%1:10:01:: | definition=a composition intended to develop one aspect of the performer's technique | examples=a study in spiccato bowing

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the context**: The target word is "study" in the sentence: "For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main **study** in 456 patients who had not received chemotherapy for their disease before."
    *   The context is a medical text (European Medicines Agency style).
    *   It discusses a clinical trial where a drug (Alimta) was tested on patients.
    *   The phrase "main study in 456 patients" strongly implies a research investigation or a clinical trial.

2.  **Analyze the candidate senses**:
    *   **Sense 1**: `study%1:04:00::` | definition=a detailed critical inspection | synonyms=survey.
        *   This refers to an investigation or examination. A clinical study/trial fits this definition broadly. It involves inspecting the effects of the drug.
    *   **Sense 2**: `study%1:09:03::` | definition=applying the mind to learning and understanding a subject (especially by reading) | synonyms=work.
        *   This refers to the process of learning (e.g., "studying for a test"). Not appropriate here.
    *   **Sense 3**: `study%1:10:00::` | definition=a written document describing the findings of some individual or group | synonyms=report, written report.
        *   This refers to the physical document (the report). The context says Alimta "has been studied in one main study". While a study produces a document, the act/event described here is the trial itself involving 456 patients. However, sometimes "study" is used metonymically. Let's look at Sense 1 again.
    *   **Sense 4**: `study%1:09:04::` | definition=a state of deep mental absorption.
        *   Not relevant.
    *   **Sense 5**: `study%1:06:00::` | definition=a room used for reading and writing and studying.
        *   Not relevant.
    *   **Sense 6**: `study%1:09:02::` | definition=a branch of knowledge | synonyms=discipline, subject.
        *   Not relevant.
    *   **Sense 7**: `study%1:06:01::` | definition=preliminary drawing for later elaboration.
        *   Not relevant.
    *   **Sense 8**: `study%1:09:01::` | definition=attentive consideration and meditation.
        *   Not relevant.
    *   **Sense 9**: `study%1:18:00::` | definition=someone who memorizes quickly and easily.
        *   Not relevant.
    *   **Sense 10**: `study%1:10:01::` | definition=a composition intended to develop one aspect of the performer's technique.
        *   Musical study. Not relevant.

3.  **Differentiate between Sense 1 and Sense 3**:
    *   Sense 1: "a detailed critical inspection" (the act or process). Synonyms: survey.
    *   Sense 3: "a written document describing the findings..." (the artifact/report). Synonyms: report, written report.
    *   The sentence says: "Alimta has been studied in one main study".
    *   If we substitute definitions:
        *   "Alimta has been studied in one main **detailed critical inspection**." -> This fits well. It refers to the research project/trial.
        *   "Alimta has been studied in one main **written report**." -> This doesn't fit as well. You don't conduct a drug trial *in* a written report. You conduct it in a process/investigation. The "main study" refers to the clinical trial itself (the investigation), not the paper written about it later.
    *   Therefore, Sense 1 is the best fit.

4.  **Final Verification**:
    *   Context: Clinical trial.
    *   WordNet Sense 1: Detailed critical inspection (often used for surveys, scientific investigations).
    *   Example usage in WordNet for Sense 1 isn't provided in the prompt, but the definition aligns with "scientific study" or "clinical study".
    *   Index: 1.

5.  **Format Output**: JSON object `{"sense_index": 1}`.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 <t>patients</t> who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the target lemma and surface form:**
    *   Lemma: patient
    *   Surface form: patients (plural noun)

2.  **Analyze the context:**
    *   The text discusses a medicine called Alimta (pemetrexed).
    *   It mentions "treatment of malignant pleural mesothelioma".
    *   It mentions a "main study in 456 patients who had not received chemotherapy for their disease before."
    *   The patients are people receiving medical treatment for a disease (mesothelioma).

3.  **Analyze the candidate senses:**

    *   **Sense 1:**
        *   Definition: "a person who requires medical care"
        *   Examples: "the number of emergency patients has grown rapidly"
        *   Synonyms: (None listed, but semantically implies sick person, case).
        *   Fit: The context explicitly mentions a medical study ("main study"), a disease ("malignant pleural mesothelioma"), and chemotherapy. The people involved (the "patients") are receiving medical care/treatment. This matches perfectly.

    *   **Sense 2:**
        *   Definition: "the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause"
        *   Synonyms: "affected role", "patient role"
        *   Fit: This is a linguistic/grammatical definition regarding semantic roles (thematic relations). While the people in the study *are* in the patient role relative to the treatment, the word "patients" in this text is a concrete noun referring to the *people*, not the abstract grammatical role. The context is medical/pharmaceutical, not linguistic analysis. The plural form "patients" refers to multiple individuals, not a grammatical concept.

4.  **Compare and Decide:**
    *   Sense 1 refers to a person under medical care.
    *   Sense 2 refers to a linguistic concept (semantic role).
    *   The text is a Summary of Product Characteristics for a drug, discussing a clinical trial involving people with cancer. These people are "patients" in the medical sense.
    *   Therefore, Sense 1 is the correct choice.

5.  **Format the output:**
    *   The user requires a JSON object: `{"sense_index": 1}`.
    *   The user specified "Do not answer with a WordNet sense key."
    *   The user specified "Return only a JSON object".

6.  **Final Check:**
    *   Context: "456 patients who had not received chemotherapy" -> These are people needing medical care.
    *   Sense 1: person who requires medical care. Match.
    *   Sense 2: semantic role. No match.

    Index corresponds to the position in the list provided.
    1. sense_key=patient%1:18:00:: -> Index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: before
Target surface form: before
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease <t>before</t>. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=before%4:02:03:: | definition=earlier in time; previously | synonyms=earlier | examples=I had known her before; as I said before
2. sense_key=before%4:02:01:: | definition=at or in the front | synonyms=ahead, in front | examples=I see the lights of a town ahead; the road ahead is foggy

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the target word and context**:
    *   Target lemma: "before"
    *   Target surface form: "before"
    *   Context sentence: "For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease <t>before</t>."
    *   Surrounding context: The text discusses a clinical study for a cancer drug (Alimta). The specific sentence talks about patients who had not received chemotherapy *previously* or *in the past*.

2.  **Analyze Candidate Sense 1**:
    *   Sense key: `before%4:02:03::`
    *   Definition: "earlier in time; previously"
    *   Synonyms: "earlier"
    *   Examples: "I had known her before"; "as I said before"
    *   Fit: The context says patients hadn't received chemotherapy "before". This implies "prior to this point in time" or "previously". This fits perfectly. "Had not received chemotherapy before" is equivalent to "had not previously received chemotherapy".

3.  **Analyze Candidate Sense 2**:
    *   Sense key: `before%4:02:01::`
    *   Definition: "at or in the front"
    *   Synonyms: "ahead, in front"
    *   Examples: "I see the lights of a town ahead"; "the road ahead is foggy"
    *   Fit: This refers to spatial location (being in front). Does the sentence mean patients hadn't received chemotherapy "in front"? No. It refers to a temporal sequence (prior to the study). Therefore, this sense is incorrect.

4.  **Conclusion**:
    *   Sense 1 is the correct fit. It denotes a temporal relationship, meaning "at an earlier time".
    *   Sense 2 denotes a spatial relationship.
    *   The context clearly indicates a temporal relationship (the patients' treatment history).

5.  **Formulate Output**:
    *   The user wants a JSON object: `{"sense_index": 1}`.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: effect
Target surface form: effects
Context:
How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The <t>effects</t> of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past.

Candidate senses:
1. sense_key=effect%1:19:00:: | definition=a phenomenon that follows and is caused by some previous phenomenon | synonyms=consequence, outcome, result, event, issue, upshot | examples=the magnetic effect was greater when the rod was lengthwise; his decision had depressing consequences for business
2. sense_key=effect%1:07:00:: | definition=an outward appearance | synonyms=impression | examples=he made a good impression; I wanted to create an impression of success
3. sense_key=effect%1:09:00:: | definition=an impression (especially one that is artificial or contrived) | examples=he just did it for effect
4. sense_key=effect%1:10:00:: | definition=the central meaning or theme of a speech or literary work | synonyms=essence, burden, core, gist
5. sense_key=effect%1:07:01:: | definition=(of a law) having legal validity | synonyms=force | examples=the law is still in effect
6. sense_key=effect%1:26:00:: | definition=a symptom caused by an illness or a drug | examples=the effects of sleep loss; the effect of the anesthetic

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "effects" (plural form of "effect"). Let me analyze the context.

The context is discussing a medical drug called Alimta (pemetrexed) and how it has been studied. The sentence says: "The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone." and "the effects of Alimta were compared with those of docetaxel".

In this medical context, "effects" refers to the outcomes or results of the drug treatment - specifically what happens when patients take the medication. This is about the therapeutic effects (or side effects) of a drug.

Let me look at the candidate senses:

1. "a phenomenon that follows and is caused by some previous phenomenon" - This is a general sense about consequences/outcomes. Synonyms include consequence, outcome, result.

2. "an outward appearance" - This is about visual impressions, not relevant here.

3. "an impression (especially one that is artificial or contrived)" - Not relevant in this medical context.

4. "the central meaning or theme of a speech or literary work" - Not relevant.

5. "(of a law) having legal validity" - Not relevant, this is about laws.

6. "a symptom caused by an illness or a drug" - This is specifically about medical effects, with examples like "the effects of sleep loss; the effect of the anesthetic."

Sense 6 is specifically about drug effects, which perfectly matches this context about the effects of a chemotherapy drug (Alimta). The examples given ("the effects of sleep loss; the effect of the anesthetic") are medical contexts, just like the current context.

So the best sense is sense_index 6.

provider: Friendli