[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: dehydration
Target surface form: dehydration
Context:
How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent <t>dehydration</t>) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects.

Candidate senses:
1. sense_key=dehydration%1:26:00:: | definition=dryness resulting from the removal of water | synonyms=desiccation
2. sense_key=dehydration%1:26:01:: | definition=depletion of bodily fluids
3. sense_key=dehydration%1:22:00:: | definition=the process of extracting moisture | synonyms=desiccation, drying up, evaporation

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

content:
```json
{"sense_index": 2}
```

reasoning_content:
1.  **Analyze the Target**: The target word is "dehydration" (noun).
2.  **Analyze the Context**: The text is a medical description of the drug Alimta.
    *   Sentence: "When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose."
    *   Key phrase: "fluids (to prevent dehydration)".
    *   Action: Giving fluids prevents "dehydration".
    *   Domain: Medical/physiological context. Vomiting causes loss of fluids. Giving fluids restores them.
3.  **Analyze the Candidate Senses**:
    *   *Sense 1*: `dehydration%1:26:00::` | definition="dryness resulting from the removal of water" | synonyms=[desiccation].
        *   This refers to a state of dryness or the result of removing water (often from substances, food, etc.). It's a static state.
    *   *Sense 2*: `dehydration%1:26:01::` | definition="depletion of bodily fluids".
        *   This refers specifically to the physiological condition of lacking enough fluids in the body.
        *   "Depletion of bodily fluids" matches "prevent [loss of fluids]". Vomiting leads to depletion of fluids. Giving fluids prevents this depletion.
    *   *Sense 3*: `dehydration%1:22:00::` | definition="the process of extracting moisture" | synonyms=[desiccation, drying up, evaporation].
        *   This refers to the *process* of removing moisture, often technical (like dehydrating food) or chemical.
4.  **Evaluate Fit**:
    *   In the context "prevent dehydration" by giving "fluids", we are talking about a physiological state/condition of the patient.
    *   Sense 1 ("dryness") is too generic and often implies a result of a physical process on an object (like desiccation).
    *   Sense 3 ("process of extracting") is an action/process. While dehydration can be a process, in medical contexts involving patients, "dehydration" usually refers to the *condition* of the patient (the result of the process of losing fluids).
    *   Sense 2 ("depletion of bodily fluids") is the precise medical definition. It aligns perfectly with the context of a patient needing fluids to prevent the depletion of bodily fluids caused by vomiting.
5.  **Select Best Sense**: Sense 2 is the correct medical sense.
6.  **Format Output**: The user wants a JSON object `{"sense_index": X}`.
    *   Sense 2 corresponds to index 2 (assuming 1-based indexing based on the list provided).
    *   Wait, let me check the list numbering provided in the prompt.
    *   1. sense_key=...
    *   2. sense_key=...
    *   3. sense_key=...
    *   So the index is 2.

    Let's double check sense indices.
    Sense 1: dryness (result state).
    Sense 2: depletion of bodily fluids (medical condition/state).
    Sense 3: process (action).

    The context is preventing a medical condition by administering fluids. This is Sense 2.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: give
Target surface form: given
Context:
How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be <t>given</t> before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects.

Candidate senses:
1. sense_key=give%2:40:03:: | definition=cause to have, in the abstract sense or physical sense | examples=She gave him a black eye; The draft gave me a cold
2. sense_key=give%2:40:05:: | definition=be the cause or source of | synonyms=yield, afford | examples=He gave me a lot of trouble; Our meeting afforded much interesting information
3. sense_key=give%2:40:00:: | definition=transfer possession of something concrete or abstract to somebody | examples=I gave her my money; can you give me lessons?
4. sense_key=give%2:40:07:: | definition=convey or reveal information | examples=Give one's name
5. sense_key=give%2:32:01:: | definition=convey, as of a compliment, regards, attention, etc.; bestow | synonyms=pay | examples=Don't pay him any mind; give the orders
6. sense_key=give%2:36:02:: | definition=organize or be responsible for | synonyms=hold, throw, have, make | examples=hold a reception; have, throw, or make a party
7. sense_key=give%2:32:00:: | definition=convey or communicate; of a smile, a look, a physical gesture | synonyms=throw | examples=Throw a glance; She gave me a dirty look
8. sense_key=give%2:40:01:: | definition=give as a present; make a gift of | synonyms=gift, present | examples=What will you give her for her birthday?
9. sense_key=give%2:36:03:: | definition=cause to happen or be responsible for | synonyms=yield | examples=His two singles gave the team the victory
10. sense_key=give%2:31:02:: | definition=dedicate | synonyms=pay, devote | examples=give thought to; give priority to
11. sense_key=give%2:36:00:: | definition=give or supply | synonyms=render, yield, return, generate | examples=The cow brings in 5 liters of milk; This year's crop yielded 1,000 bushels of corn
12. sense_key=give%2:40:09:: | definition=transmit (knowledge or skills) | synonyms=impart, leave, pass on | examples=give a secret to the Russians; leave your name and address here
13. sense_key=give%2:36:01:: | definition=bring about | synonyms=establish | examples=The trompe l'oeil-illusion establishes depth
14. sense_key=give%2:40:02:: | definition=leave with; give temporarily | examples=Can I give you my keys while I go in the pool?; Can I give you the children for the weekend?
15. sense_key=give%2:41:00:: | definition=emit or utter | examples=Give a gulp; give a yelp
16. sense_key=give%2:40:10:: | definition=endure the loss of | synonyms=sacrifice | examples=He gave his life for his children; I gave two sons to the war
17. sense_key=give%2:40:06:: | definition=place into the hands or custody of | synonyms=pass, hand, reach, pass on, turn over | examples=hand me the spoon, please; Turn the files over to me, please
18. sense_key=give%2:32:03:: | definition=give entirely to a specific person, activity, or cause | synonyms=dedicate, consecrate, commit, devote | examples=She committed herself to the work of God; give one's talents to a good cause
19. sense_key=give%2:40:13:: | definition=give (as medicine) | examples=I gave him the drug
20. sense_key=give%2:40:14:: | definition=give or convey physically | synonyms=apply | examples=She gave him First Aid; I gave him a punch in the nose
21. sense_key=give%2:32:02:: | definition=bestow | synonyms=render | examples=give homage; render thanks
22. sense_key=give%2:40:11:: | definition=bestow, especially officially | synonyms=grant | examples=grant a degree; give a divorce
23. sense_key=give%2:38:00:: | definition=move in order to make room for someone for something | synonyms=move over, give way, ease up, yield | examples=The park gave way to a supermarket; `Move over,' he told the crowd
24. sense_key=give%2:34:00:: | definition=give food to | synonyms=feed | examples=Feed the starving children in India; don't give the child this tough meat
25. sense_key=give%2:40:08:: | definition=contribute to some cause | synonyms=contribute, chip in, kick in | examples=I gave at the office
26. sense_key=give%2:38:13:: | definition=break down, literally or metaphorically | synonyms=collapse, fall in, cave in, give way, break, founder | examples=The wall collapsed; The business collapsed
27. sense_key=give%2:31:00:: | definition=estimate the duration or outcome of something | examples=He gave the patient three months to live; I gave him a very good chance at success
28. sense_key=give%2:41:10:: | definition=execute and deliver | examples=Give bond
29. sense_key=give%2:40:12:: | definition=deliver in exchange or recompense | examples=I'll give you three books for four CDs
30. sense_key=give%2:40:15:: | definition=afford access to | synonyms=afford, open | examples=the door opens to the patio; The French doors give onto a terrace
31. sense_key=give%2:36:13:: | definition=present to view | examples=He gave the sign to start
32. sense_key=give%2:36:12:: | definition=perform for an audience | examples=Pollini is giving another concert in New York
33. sense_key=give%2:35:00:: | definition=be flexible under stress of physical force | synonyms=yield | examples=This material doesn't give
34. sense_key=give%2:34:10:: | definition=propose | examples=He gave the first of many toasts at the birthday party
35. sense_key=give%2:32:11:: | definition=accord by verdict | examples=give a decision for the plaintiff
36. sense_key=give%2:32:08:: | definition=manifest or show | examples=This student gives promise of real creativity; The office gave evidence of tampering
37. sense_key=give%2:32:15:: | definition=offer in good faith | examples=He gave her his word
38. sense_key=give%2:32:14:: | definition=submit for consideration, judgment, or use | examples=give one's opinion; give an excuse
39. sense_key=give%2:32:09:: | definition=guide or direct, as by behavior of persuasion | examples=You gave me to think that you agreed with me
40. sense_key=give%2:32:07:: | definition=allow to have or take | examples=I give you two minutes to respond
41. sense_key=give%2:32:10:: | definition=inflict as a punishment | examples=She gave the boy a good spanking; The judge gave me 10 years
42. sense_key=give%2:30:13:: | definition=occur | examples=what gives?
43. sense_key=give%2:29:11:: | definition=consent to engage in sexual intercourse with a man | examples=She gave herself to many men
44. sense_key=give%2:29:10:: | definition=proffer (a body part) | examples=She gave her hand to her little sister

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

finish_reason: stop

role: assistant

reasoning_content:
Let me analyze the context and the target word "given" to determine its correct sense.

The context is about the medical administration of a drug called Alimta. The sentence is:
"When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be <t>given</t> before or after the cisplatin dose."

In this context, "given" refers to administering fluids and anti-emetic medicine to patients. It's about providing medical treatment, specifically administering substances like medicine or fluids in a medical context.

Let me look at the candidate senses:

1. sense_key=give%2:40:03:: - "cause to have, in the abstract sense or physical sense" - This is too general.

2. sense_key=give%2:40:05:: - "be the cause or source of" - This is about causing something, not administering.

3. sense_key=give%2:40:00:: - "transfer possession of something concrete or abstract to somebody" - This is about transferring ownership, not about administering medicine.

4. sense_key=give%2:40:07:: - "convey or reveal information" - This is about information, not medical administration.

5. sense_key=give%2:32:01:: - "convey, as of a compliment, regards, attention, etc.; bestow" - Not applicable here.

6. sense_key=give%2:36:02:: - "organize or be responsible for" - Not applicable.

7. sense_key=give%2:32:00:: - "convey or communicate; of a smile, a look, a physical gesture" - Not applicable.

8. sense_key=give%2:40:01:: - "give as a present; make a gift of" - Not applicable in a medical context.

9. sense_key=give%2:36:03:: - "cause to happen or be responsible for" - Not applicable.

10. sense_key=give%2:31:02:: - "dedicate" - Not applicable.

11. sense_key=give%2:36:00:: - "give or supply" - This could potentially apply, but it's more about supplying products or resources.

12. sense_key=give%2:40:09:: - "transmit (knowledge or skills)" - Not applicable.

13. sense_key=give%2:36:01:: - "bring about" - Not applicable.

14. sense_key=give%2:40:02:: - "leave with; give temporarily" - Not applicable.

15. sense_key=give%2:41:00:: - "emit or utter" - Not applicable.

16. sense_key=give%2:40:10:: - "endure the loss of" - Not applicable.

17. sense_key=give%2:40:06:: - "place into the hands or custody of" - This is about physically handing something over, not administering medicine.

18. sense_key=give%2:32:03:: - "give entirely to a specific person, activity, or cause" - Not applicable.

19. sense_key=give%2:40:13:: - "give (as medicine)" - This seems to be the most fitting sense. The definition explicitly mentions medicine, and the example "I gave him the drug" aligns with our context where fluids and anti-emetic medicine are being given to patients.

20. sense_key=give%2:40:14:: - "give or convey physically" - This could apply but is less specific than sense 19.

21. sense_key=give%2:32:02:: - "bestow" - Not applicable.

22. sense_key=give%2:40:11:: - "bestow, especially officially" - Not applicable.

23. sense_key=give%2:38:00:: - "move in order to make room for someone for something" - Not applicable.

24. sense_key=give%2:34:00:: - "give food to" - Not applicable.

25. sense_key=give%2:40:08:: - "contribute to some cause" - Not applicable.

26. sense_key=give%2:38:13:: - "break down, literally or metaphorically" - Not applicable.

27. sense_key=give%2:31:00:: - "estimate the duration or outcome of something" - Not applicable.

28. sense_key=give%2:41:10:: - "execute and deliver" - Not applicable.

29. sense_key=give%2:40:12:: - "deliver in exchange or recompense" - Not applicable.

30. sense_key=give%2:40:15:: - "afford access to" - Not applicable.

31. sense_key=give%2:36:13:: - "present to view" - Not applicable.

32. sense_key=give%2:36:12:: - "perform for an audience" - Not applicable.

33. sense_key=give%2:35:00:: - "be flexible under stress of physical force" - Not applicable.

34. sense_key=give%2:34:10:: - "propose" - Not applicable.

35. sense_key=give%2:32:11:: - "accord by verdict" - Not applicable.

36. sense_key=give%2:32:08:: - "manifest or show" - Not applicable.

37. sense_key=give%2:32:15:: - "offer in good faith" - Not applicable.

38. sense_key=give%2:32:14:: - "submit for consideration, judgment, or use" - Not applicable.

39. sense_key=give%2:32:09:: - "guide or direct, as by behavior of persuasion" - Not applicable.

40. sense_key=give%2:32:10:: - "allow to have or take" - Not applicable.

41. sense_key=give%2:32:07:: - "inflict as a punishment" - Not applicable.

42. sense_key=give%2:30:13:: - "occur" - Not applicable.

43. sense_key=give%2:29:11:: - "consent to engage in sexual intercourse with a man" - Not applicable.

44. sense_key=give%2:29:10:: - "proffer (a body part)" - Not applicable.

The most appropriate sense is clearly sense 19: "give (as medicine)" with the example "I gave him the drug". This directly matches our context where fluids and anti-emetic medicine are being administered to patients.

format: unknown

native_finish_reason: stop

provider: Together

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: before
Target surface form: before
Context:
How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given <t>before</t> or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects.

Candidate senses:
1. sense_key=before%4:02:03:: | definition=earlier in time; previously | synonyms=earlier | examples=I had known her before; as I said before
2. sense_key=before%4:02:01:: | definition=at or in the front | synonyms=ahead, in front | examples=I see the lights of a town ahead; the road ahead is foggy

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the target word**: The lemma is "before", and the surface form is "before". The context is a medical text describing how to use the drug Alimta. The specific sentence is: "When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given <t>before</t> or after the cisplatin dose."

2.  **Analyze the candidate senses**:
    *   Sense 1: `before%4:02:03::` | Definition: "earlier in time; previously" | Synonyms: "earlier" | Examples: "I had known her before; as I said before". This sense relates to time. It indicates that one event happens prior to another event.
    *   Sense 2: `before%4:02:01::` | Definition: "at or in the front" | Synonyms: "ahead, in front" | Examples: "I see the lights of a town ahead; the road ahead is foggy". This sense relates to spatial position.

3.  **Analyze the context**:
    *   The sentence discusses the administration of medicines (anti-emetic and fluids) relative to the administration of cisplatin.
    *   The phrase is "given before or after the cisplatin dose".
    *   "After" is a temporal preposition (indicating time).
    *   The contrast is between the timing of the supportive care (anti-emetics/fluids) and the chemotherapy dose.
    *   One administers medicine *earlier in time* than the cisplatin dose, or *later in time* than the cisplatin dose.
    *   It does not refer to spatial position (in front of the physical dose).

4.  **Match context to senses**:
    *   Does "before" mean "at or in the front" here? No, it's not about spatial location.
    *   Does "before" mean "earlier in time" here? Yes. The medicine is administered prior to the cisplatin dose.

5.  **Determine the best index**:
    *   Sense 1 fits perfectly (temporal relationship).
    *   Sense 2 fits spatial relationships.

    Therefore, the correct sense is Sense 1.

6.  **Format the output**: The user wants a JSON object `{"sense_index": X}`. Since Sense 1 is the correct one, the index is 1.

    Wait, let me double-check the numbering. The list provided is:
    1. sense_key=before%4:02:03:: ...
    2. sense_key=before%4:02:01:: ...

    Yes, Sense 1 corresponds to index 1.

    Let's verify the WordNet sense keys usually associated.
    `before%4:02:03::` corresponds to the adverb "earlier in time".
    `before%4:02:01::` corresponds to the adverb "at or in the front".
    The context "given before ... the cisplatin dose" uses "before" as a preposition (or adverb depending on analysis, but here it takes an object "the cisplatin dose", so it's a preposition).
    WordNet 3.1 or 3.0 structures:
    There are prepositional senses too.
    Let's look at the provided candidates strictly.
    Candidate 1: "earlier in time; previously".
    Candidate 2: "at or in the front".

    Context: "given [before] or [after] the cisplatin dose".
    "After" clearly indicates time. "Before" acts as the antonym here regarding the timeline of administration.
    Therefore, it matches the definition "earlier in time".

    Sense 1 is the correct choice.

provider: AtlasCloud


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: after
Target surface form: after
Context:
How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or <t>after</t> the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects.

Candidate senses:
1. sense_key=after%4:02:01:: | definition=happening at a time subsequent to a reference time | synonyms=subsequently, later, afterwards, afterward, later on | examples=he apologized subsequently; he's going to the store but he'll be back here later
2. sense_key=after%4:02:00:: | definition=behind or in the rear | examples=and Jill came tumbling after

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the Request:**
    *   Target lemma: *after*
    *   Target surface form: *after*
    *   Context: A medical text describing the administration of the drug Alimta, specifically regarding timing relative to cisplatin dose ("...should also be given before or after the cisplatin dose.").
    *   Candidate senses:
        1.  sense_key=after%4:02:01:: | definition=happening at a time subsequent to a reference time | synonyms=subsequently, later, afterwards, afterward, later on | examples=he apologized subsequently; he's going to the store but he'll be back here later
        2.  sense_key=after%4:02:00:: | definition=behind or in the rear | examples=and Jill came tumbling after
    *   Task: Choose the single best indexed sense (1 or 2) and return a JSON object `{"sense_index": N}`. No hedging. No WordNet sense keys in the output.

2.  **Analyze the Context:**
    *   Sentence: "When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or <t>after</t> the cisplatin dose."
    *   Usage: The word "after" is used as a preposition here (or possibly a conjunction, but in WordNet adverb/preposition distinctions can vary; let's look at the sense definitions provided).
    *   Meaning: The administration of fluids/medicine happens at a time *subsequent* to the administration of the cisplatin dose. It is a temporal relationship. "Before or after" refers to time relative to the event (cisplatin dose).

3.  **Analyze Candidate Sense 1:**
    *   Definition: "happening at a time subsequent to a reference time"
    *   Synonyms: subsequently, later, afterwards...
    *   Examples: "he apologized subsequently" (temporal).
    *   Fit: This describes the temporal sequence. Giving fluids *after* the cisplatin dose means giving them later in time than the cisplatin dose. This matches the definition perfectly.

4.  **Analyze Candidate Sense 2:**
    *   Definition: "behind or in the rear"
    *   Examples: "and Jill came tumbling after"
    *   Fit: This refers to spatial position (following behind someone). While Jack and Jill is a classic example of spatial following (often with a temporal overlap), the primary definition "behind or in the rear" does not fit the medical context of scheduling drug administration. We are talking about a schedule/timeline, not physical positioning in a line.

5.  **Comparison:**
    *   Sense 1 focuses on time (subsequent to a reference time).
    *   Sense 2 focuses on space (behind/in the rear).
    *   The context is medical administration schedule: "before or after the cisplatin dose". This is clearly temporal.
    *   Therefore, Sense 1 is the correct choice.

6.  **Format Output:**
    *   The user wants JSON: `{"sense_index": 1}` (since sense 1 is the first candidate provided).


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: dose
Target surface form: dose
Context:
How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin <t>dose</t>. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects.

Candidate senses:
1. sense_key=dose%1:06:00:: | definition=a measured portion of medicine taken at any one time | synonyms=dosage
2. sense_key=dose%1:23:00:: | definition=the quantity of an active agent (substance or radiation) taken in or absorbed at any one time | synonyms=dosage
3. sense_key=dose%1:26:00:: | definition=a communicable infection transmitted by sexual intercourse or genital contact | synonyms=venereal disease, VD, venereal infection, social disease, Cupid's itch, Cupid's disease
4. sense_key=dose%1:06:01:: | definition=street name for lysergic acid diethylamide | synonyms=acid, back breaker, battery-acid, dot, Elvis, loony toons

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

content:
```json
{"sense_index": 1}
```

reasoning_content:
1.  **Analyze the Request:**
    *   Task: Word Sense Disambiguation (WSD).
    *   Target lemma: `dose`.
    *   Target surface form: `dose`.
    *   Context: A paragraph describing the administration of the drug "Alimta" (pemetrexed), mentioning specific amounts (500 mg), frequency, and side effects.
    *   Candidate senses: Four options provided with definitions and synonyms.
    *   Constraint: Choose the single best indexed sense. Do not hedge. Return only a JSON object `{"sense_index": X}`.

2.  **Analyze the Context:**
    *   The text discusses a medical drug (Alimta) used in anticancer chemotherapy.
    *   Phrases: "recommended dose of Alimta is 500 mg", "dose reduced", "cisplatin dose".
    *   The word "dose" refers to a specific measured amount of the medication administered at one time or according to a schedule.

3.  **Analyze the Candidate Senses:**
    *   *Sense 1:* `dose%1:06:00::` | Definition: "a measured portion of medicine taken at any one time" | Synonyms: "dosage".
        *   Fit: This fits very well. It explicitly mentions "measured portion of medicine". The context talks about 500 mg of Alimta.
    *   *Sense 2:* `dose%1:23:00::` | Definition: "the quantity of an active agent (substance or radiation) taken in or absorbed at any one time" | Synonyms: "dosage".
        *   Fit: This is also a strong contender. Alimta is an active agent (substance). However, Sense 1 specifies "medicine", which Alimta is. Sense 2 is broader (could be radiation, pesticides, etc.). In a medical/pharmaceutical context, Sense 1 is usually the preferred specific sense.
    *   *Sense 3:* `dose%1:26:00::` | Definition: "a communicable infection transmitted by sexual intercourse..." | Synonyms: "venereal disease...".
        *   Fit: Completely irrelevant. No sexual context.
    *   *Sense 4:* `dose%1:06:01::` | Definition: "street name for lysergic acid diethylamide" | Synonyms: "acid...".
        *   Fit: Irrelevant. Not a slang term for LSD here.

4.  **Compare Sense 1 and Sense 2:**
    *   WordNet often distinguishes between the general concept of a quantity of an agent (Sense 2) and the specific medical administration (Sense 1).
    *   The text is about a specific medicine ("Alimta") administered to a patient.
    *   Sense 1 definition: "a measured portion of medicine taken at any one time".
    *   Sense 2 definition: "the quantity of an active agent... taken in or absorbed".
    *   While Sense 2 applies, Sense 1 is more specific to the domain ("medicine"). The text says "recommended dose... is 500 mg". This is a measured portion of medicine.
    *   Let's look at the hierarchy.
        *   Sense 1 is under the "artifact" or "medicine" hierarchy (indicated by `1:06` usually relating to artifacts/objects, specifically medicinal drugs).
        *   Sense 2 is under `1:23` (usually relating to measure/quantity or phenomenon).
    *   Usually, when referring to a prescribed amount of a drug in a clinical setting, Sense 1 (measured portion of medicine) is the standard mapping.
    *   However, checking common WSD practices for WordNet:
        *   WordNet 3.0 definitions:
            *   01: a measured portion of medicine taken at any one time.
            *   02: the quantity of an active agent (substance or radiation) taken in or absorbed at any one time.
    *   The context emphasizes the *prescribed amount* ("recommended dose", "dose reduced").
    *   Sense 1 is "a measured portion of medicine". This is the exact definition for a pharmaceutical context. Sense 2 includes radiation, which is not happening here. Specificity principle favors Sense 1.

5.  **Select the Best Index:**
    *   Index 1 corresponds to `dose%1:06:00::`.
    *   This matches "a measured portion of medicine".

6.  **Final Check:**
    *   Context: "The recommended dose of Alimta..."
    *   Sense 1: "measured portion of medicine".
    *   This is a perfect match.

    *   JSON format required: `{"sense_index": 1}`.

provider: StreamLake


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: treatment
Target surface form: Treatment
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. <t>Treatment</t> should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=treatment%1:04:00:: | definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) | synonyms=intervention
2. sense_key=treatment%1:04:01:: | definition=the management of someone or something | synonyms=handling | examples=the handling of prisoners; the treatment of water sewage
3. sense_key=treatment%1:07:00:: | definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture
4. sense_key=treatment%1:10:00:: | definition=an extended communication (often interactive) dealing with some particular topic | synonyms=discussion, discourse | examples=the book contains an excellent discussion of modal logic; his treatment of the race question is badly biased

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the Request:**
    *   Target lemma: `treatment`
    *   Target surface form: `Treatment`
    *   Context: A medical text describing the administration, dosage, and management of a drug called Alimta (pemetrexed) for cancer. The specific sentence is: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects."
    *   Candidate senses: Four options provided with definitions, synonyms, and examples.
    *   Constraints: Choose the single best indexed sense. Do not hedge. Return only JSON `{"sense_index": X}`.

2.  **Analyze the Context:**
    *   The text is about medical care ("anticancer chemotherapy", "doctor", "dose", "patients", "side effects", "kidney problems").
    *   The specific instance of "Treatment" refers to the overall regimen of administering Alimta to the patient to fight cancer. It involves medical procedures (intravenous infusion) and management of the patient's condition with the drug.
    *   The sentence talks about delaying, discontinuing, or reducing the dose of this medical intervention based on the patient's health metrics (blood counts).

3.  **Analyze the Candidate Senses:**

    *   **Sense 1:** `treatment%1:04:00::`
        *   Definition: "care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)"
        *   Synonyms: "intervention"
        *   Fit: This is a strong candidate. The context is explicitly medical. Alimta is an anticancer drug. The "treatment" is the medical procedure/applications intended to relieve illness (cancer).

    *   **Sense 2:** `treatment%1:04:01::`
        *   Definition: "the management of someone or something"
        *   Synonyms: "handling"
        *   Examples: "the handling of prisoners; the treatment of water sewage"
        *   Fit: While there is an element of "management" in a clinical trial or administration, this sense usually refers to how one deals with a substance (like water) or a person in a non-medical/procedural sense (like prisoners). It doesn't capture the "medical care" aspect as strongly as Sense 1.

    *   **Sense 3:** `treatment%1:07:00::`
        *   Definition: "a manner of dealing with something artistically"
        *   Examples: "his treatment of space borrows from Italian architecture"
        *   Fit: Irrelevant. No artistic context here.

    *   **Sense 4:** `treatment%1:10:00::`
        *   Definition: "an extended communication (often interactive) dealing with some particular topic"
        *   Synonyms: "discussion, discourse"
        *   Examples: "the book contains an excellent discussion..."
        *   Fit: Irrelevant. This refers to a written or spoken exposition.

4.  **Compare Sense 1 and Sense 2:**
    *   Sense 1 explicitly mentions "medical procedures" and "relieve illness". The context is entirely about medical procedures (infusions, doses) and relieving illness (anticancer). The word "intervention" fits well here.
    *   Sense 2 is broader ("management"). While a doctor manages the patient, the word "treatment" in medical contexts almost always maps to Sense 1 (medical care). For example, "cancer treatment" falls under Sense 1.
    *   Therefore, Sense 1 is the correct choice.

5.  **Determine the Index:**
    *   Sense 1 is the first entry in the list provided by the user.
    *   Index = 1.

6.  **Final Verification:**
    *   Sentence: "Treatment should be delayed..."
    *   Meaning: The medical care/drug administration regimen.
    *   Match: Sense 1 definition "care provided to improve a situation (especially medical procedures...)". Perfect match.

7.  **Construct Output:**
    *   JSON format: `{"sense_index": 1}`.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: delay
Target surface form: delayed
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be <t>delayed</t> or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=delay%2:30:00:: | definition=cause to be slowed down or delayed | synonyms=detain, hold up | examples=Traffic was delayed by the bad weather; she delayed the work that she didn't want to perform
2. sense_key=delay%2:42:00:: | definition=act later than planned, scheduled, or required | examples=Don't delay your application to graduate school or else it won't be considered
3. sense_key=delay%2:30:01:: | definition=stop or halt | synonyms=stay, detain | examples=Please stay the bloodshed!
4. sense_key=delay%2:30:05:: | definition=slow the growth or development of | synonyms=check, retard | examples=The brain damage will retard the child's language development

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
The target word is "delayed" in the context: "Treatment should be delayed or discontinued, or the dose reduced..."
The options are:
1. delay%2:30:00:: cause to be slowed down or delayed | synonyms=detain, hold up
2. delay%2:42:00:: act later than planned, scheduled, or required
3. delay%2:30:01:: stop or halt | synonyms=stay, detain
4. delay%2:30:05:: slow the growth or development of | synonyms=check, retard

In the context "Treatment should be delayed or discontinued", delayed means postponed or held up, i.e., the treatment is not given at the scheduled time. "Discontinued" means stopped completely. "Delayed" means postponed/slowed down/held up.
Wait, sense 1: "cause to be slowed down or delayed" - this applies to causing a process to be postponed.
Sense 2: "act later than planned" - this is an intransitive use (delaying one's application is similar, but "delay your application" is transitive). Sense 2 is usually intransitive, though the example has a direct object ("delay your application").
Sense 3: "stop or halt" - delayed is coordinated with "discontinued", but it means postponed rather than stopped.
Sense 4: "slow the growth or development of" - not applicable here.

Let's look closely at Sense 1: "cause to be slowed down or delayed" - synonyms: detain, hold up.
"Traffic was delayed" - held up, postponed.
"she delayed the work" - held up the work, postponed the work.

In "Treatment should be delayed", it means the treatment is postponed, not given on schedule. This fits "cause to be slowed down or delayed" or "act later than planned".
Wait, "delayed" here is a passive construction of a transitive verb ("someone delays the treatment"). Thus, Sense 1 (transitive: cause to be delayed) is more appropriate than Sense 2 (usually intransitive: act later than planned).
Sense 1 definition: cause to be slowed down or delayed.
Synonyms: detain, hold up.
Examples: Traffic was delayed... she delayed the work...

Therefore, Sense 1 is the best fit for the transitive/postponement meaning.

Let's check if Sense 3 ("stop or halt") is meant to be closer to "discontinued". But "delayed or discontinued" implies two different actions: one is postponing (delay), the other is stopping (discontinue). So Sense 1 is better.

Let's review the WordNet senses for "delay":
Verb:
1: detain, hold up, delay -- cause to be slowed down or delayed
2: delay, wait, hold off, put off, postpone, defer, remit, put over -- act later than planned, scheduled, or required
3: stay, detain, delay -- stop or halt
4: check, retard, delay -- slow the growth or development of

"delay%2:30:00::" corresponds to WordNet 3.0 sense 1.
"delay%2:42:00::" corresponds to WordNet 3.0 sense 2.
Wait, Sense 2 in WordNet: "act later than planned, scheduled, or required". But the example is "Don't delay your application to graduate school or else it won't be considered", which is transitive. Actually, WordNet example for Sense 2 is "Don't delay your application to graduate school or else it won't be considered". Wait, "delay" in this example is transitive. But the definition "act later than planned" usually fits the intransitive usage ("I delayed").
However, "delay the treatment" means "postpone the treatment". The definition of Sense 1 is "cause to be slowed down or delayed". If I delay the treatment, I cause the treatment to be delayed. This perfectly matches Sense 1.

Wait, let's consider Sense 1 again. "cause to be slowed down or delayed".
Is "delay the treatment" sense 1 or 2?
Actually, WordNet has Sense 1: "cause to be slowed down or delayed" (detain, hold up).
Sense 2: "act later than planned, scheduled, or required" (postpone, put off, defer).
Wait, synonyms for Sense 2: delay, wait, hold off, put off, postpone, defer, remit, put over.
If the synonym for Sense 2 includes "postpone", and "delay the treatment" means "postpone the treatment", maybe Sense 2 is the intended sense?
Let's check the sense keys.
delay%2:30:00:: corresponds to WordNet 3.0 sense 1 (detain, hold up).
delay%2:42:00:: corresponds to WordNet 3.0 sense 2 (postpone, put off, defer).
Wait, the prompt gives the definition and synonyms!
Sense 1: definition=cause to be slowed down or delayed | synonyms=detain, hold up
Sense 2: definition=act later than planned, scheduled, or required | synonyms=(none given in prompt, wait, no synonyms listed in prompt for Sense 2, but examples=Don't delay...)

Wait, the prompt gives:
2. sense_key=delay%2:42:00:: | definition=act later than planned, scheduled, or required | examples=Don't delay your application to graduate school or else it won't be considered

If I rely on the provided text:
Sense 1: synonyms=detain, hold up. "Traffic was delayed" "she delayed the work"
Sense 2: "act later than planned, scheduled, or required". "Don't delay your application..."

In the medical context, "Treatment should be delayed" means the treatment is postponed, i.e., it will be given later than planned. So Sense 2 fits "later than planned".
Wait, Sense 1 is "cause to be slowed down or delayed". If the doctor delays the treatment, they cause it to be delayed.
But Sense 2 is "act later than planned, scheduled, or required". The example for Sense 2 is "Don't delay your application", which is transitive!
Is there a difference? "Delay your application" = act later than planned regarding your application?
"Delay the treatment" = postpone the treatment.
If we look at WordNet:
Sense 1: cause to be slowed down or delayed. "Traffic was delayed by the bad weather"; "she delayed the work that she didn't want to perform"
Sense 2: act later than planned, scheduled, or required. "Don't delay your application to graduate school or else it won't be considered"

Actually, "delay the treatment" in medicine is synonymous with "postpone the treatment". Sense 2 definition says "act later than planned", which aligns with "postpone". Sense 1 is more about "detain, hold up", like a train being delayed, or a person being delayed.
Let's check the exact WordNet definitions.
WordNet 3.0:
1. delay, detain, hold up -- cause to be slowed down or delayed; "Traffic was delayed by the bad weather"; "she delayed the work that she didn't want to perform"
2. delay, wait, hold off, postpone, defer, put off, put over, remit -- act later than planned, scheduled, or required; "Don't delay your application to graduate school or else it won't be considered"

Wait, Sense 2's synonyms include postpone, defer. "Delay" as "postpone" is definitely Sense 2.
Wait, the prompt says:
2. sense_key=delay%2:42:00:: | definition=act later than planned, scheduled, or required | examples=Don't delay your application to graduate school or else it won't be considered

In the context, "Treatment should be delayed or discontinued", "delayed" means postponed, acting later than planned (i.e., the next cycle of treatment will be given later). Thus, Sense 2 fits perfectly because "delayed" means "given later than scheduled".

Wait! Sense 1 definition is "cause to be slowed down or delayed". "delayed" in "Treatment should be delayed" is passive. "Someone delays the treatment." If "delay the treatment" means "postpone the treatment", then it's Sense 2.
Let's consider Sense 1: "cause to be slowed down or delayed". If a treatment is delayed, it means it's held up, but "delayed" in oncology specifically means "postponed" (e.g., cycle 2 is delayed by a week).
Sense 2: "act later than planned, scheduled, or required". The example "Don't delay your application" matches the syntax "delay the treatment".
So Sense 2 seems better.

Wait, is "delay the treatment" Sense 1 or Sense 2?
Sense 1: "cause to be slowed down or delayed".
Sense 2: "act later than planned...".
If I say "The train was delayed", it's Sense 1 (held up).
If I say "The meeting was delayed", it means it was postponed (Sense 2).
"Treatment should be delayed" means it should be postponed. So Sense 2.

Let's re-read carefully:
1. definition=cause to be slowed down or delayed | synonyms=detain, hold up | examples=Traffic was delayed by the bad weather; she delayed the work that she didn't want to perform
2. definition=act later than planned, scheduled, or required | examples=Don't delay your application to graduate school or else it won't be considered
3. definition=stop or halt | synonyms=stay, detain | examples=Please stay the bloodshed!
4. definition=slow the growth or development of | synonyms=check, retard | examples=The brain damage will retard the child's language development

"act later than planned, scheduled, or required" perfectly describes postponing a medical treatment. The example "Don't delay your application" shows that "delay" in this sense can take a direct object (or be passivized, as in "Treatment should be delayed").
Therefore, Sense 2 is the correct choice.

Let's double check.
In Sense 1, "she delayed the work that she didn't want to perform" - this could also be postponing! But the synonyms "detain, hold up" suggest a physical hindrance or being held up, like traffic.
In Sense 2, the definition is "act later than planned". The example "Don't delay your application" is about scheduling. Medical treatment is scheduled. "once every three weeks". So delaying it means acting later than scheduled. Sense 2 is the best fit.

I will choose Sense 2.

Wait, let's review sense keys:
1. delay%2:30:00:: -> 2:30 is the lexname "verb.change"? No, 2:30 is verb.change? Wait, 2:42 is verb.stative? No, 2:30 is verb.change. 2:42 is verb.stative? Actually 2:30:00 is verb.change, 2:42 is verb.body? No, 2:42:00 is verb.social.
Actually, the lexname doesn't matter. The prompt provides the text.
Sense 2 fits the "later than scheduled" aspect of the medical context ("once every three weeks" -> "later than scheduled").

I'll output {"sense_index": 2}.

provider: SiliconFlow


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: discontinue
Target surface form: discontinued
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or <t>discontinued</t>, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=discontinue%2:42:00:: | definition=put an end to a state or an activity | synonyms=stop, cease, give up, quit, lay off | examples=Quit teasing your little brother
2. sense_key=discontinue%2:42:01:: | definition=come to or be at an end | examples=the support from our sponsoring agency will discontinue after March 31
3. sense_key=discontinue%2:30:00:: | definition=prevent completion | synonyms=break, break off, stop | examples=stop the project; break off the negotiations

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the Target Lemma and Context:**
    *   **Lemma:** `discontinue`
    *   **Surface Form:** `discontinued`
    *   **Context:** A medical text about the drug "Alimta". The sentence is: "Treatment should be delayed or *discontinued*, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects."
    *   **Meaning in Context:** The text describes stopping the administration of the drug (treatment) due to adverse reactions (side effects). It's an active decision to stop the ongoing treatment process.

2.  **Analyze the Candidate Senses:**

    *   **Sense 1:**
        *   Definition: "put an end to a state or an activity"
        *   Synonyms: stop, cease, give up, quit, lay off
        *   Examples: "Quit teasing your little brother"
        *   Analysis: This sense involves an agent actively stopping an activity. In the context, doctors/administrators stop the treatment. "Treatment" is the "activity" or "state". This fits well. It implies agency and an active decision to stop.

    *   **Sense 2:**
        *   Definition: "come to or be at an end"
        *   Synonyms: (none listed, implied intransitive nature based on definition)
        *   Examples: "the support from our sponsoring agency will discontinue after March 31"
        *   Analysis: This sense is intransitive or ergative, focusing on the cessation happening naturally or as a state change rather than an agent actively "quitting" something. While the treatment stops, the sentence structure "Treatment should be... discontinued" uses a passive construction implying an agent (the doctor) stops it. Sense 1 is usually the transitive "stop doing something" sense, while Sense 2 is often "stop happening". The example "support... will discontinue" suggests an ending of availability or existence. The context here is about medical intervention—stopping a specific course of action. Sense 1 is a stronger fit for the transitive/passive usage of stopping a treatment regime.

    *   **Sense 3:**
        *   Definition: "prevent completion"
        *   Synonyms: break, break off, stop
        *   Examples: "stop the project; break off the negotiations"
        *   Analysis: This sense focuses on interruption or preventing the *completion* of something that hasn't finished yet. While stopping treatment does prevent completion of the full course, the core meaning in medical contexts is usually "stopping the administration" rather than just "interrupting". However, Sense 1 is broader ("put an end to a state or an activity"). Sense 3 often implies a "break" or interruption, potentially temporary or abortive before a natural conclusion. "Discontinue" in medical contexts usually means stopping the drug permanently (or at least for that specific course). Sense 1 covers "put an end to". Sense 3 covers "prevent completion". Is "discontinuing treatment" preventing completion? Yes, often. But is it the primary definition?
        *   Let's check the synonyms. Sense 1: stop, cease. Sense 3: break, break off.
        *   "Discontinued" in the text: "Treatment should be... discontinued". If you discontinue a drug, you stop giving it. You don't necessarily just "break it off" (which often implies negotiation or conversation) or "break" it. Sense 1's "put an end to a state or an activity" captures the cessation of the treatment activity perfectly. Sense 3 is often used for things like negotiations or processes that are "broken off". Sense 1 is the general transitive sense of stopping an action.
        *   Comparison: Sense 1 vs Sense 3.
            *   Sense 1: Quit teasing. Stop doing something.
            *   Sense 3: Stop the project. Break off negotiations.
            *   In medicine, "discontinue" is standard terminology for stopping a medication. It maps to "stop" or "cease" (Sense 1). "Prevent completion" (Sense 3) feels slightly distinct—it implies the thing was meant to be completed and now won't be. While true, "put an end to an activity" (Sense 1) is the fundamental definition of stopping treatment.
            *   Let's look at the definitions again. Sense 1: "put an end to a state or an activity". Sense 3: "prevent completion".
            *   If I "discontinue" a subscription, I stop it (Sense 1/2). If I "discontinue" a treatment, I stop the administration.
            *   WordNet distinctions can be subtle. Sense 3 is "break, break off". "Break off" implies abruptness or suspension. "Discontinue" treatment can be abrupt or gradual, but it means "stop".
            *   Sense 1 examples: "Quit teasing". "Stop" is a synonym.
            *   Sense 3 examples: "stop the project".
            *   Wait, "stop the project" is listed under Sense 3 ("prevent completion"). "Quit teasing" is Sense 1.
            *   Is stopping a treatment more like "Quit teasing" (stop a behavior) or "Stop the project" (abort a plan)?
            *   Actually, "discontinue" is often Sense 1 in many WSD tasks. Let's verify the specific WordNet 3.0 (or similar) entries.
            *   WN 3.0:
                *   1: put an end to a state or an activity. (stop, cease, give up, quit, lay off).
                *   2: come to or be at an end. (intransitive).
                *   3: prevent completion. (break, break off, stop).
            *   The usage "Treatment should be ... discontinued" is passive. The active form is "The doctor discontinued the treatment".
            *   "Discontinue" maps strongly to "stop" in medical texts.
            *   Does Sense 1 or Sense 3 map better to "stopping a drug"?
            *   Sense 1: "put an end to an activity". Treatment is an activity. This fits.
            *   Sense 3: "prevent completion". "Stop the project". A course of treatment is a project/plan. If you stop it, you prevent its completion.
            *   However, Sense 1 includes "stop" as a synonym. Sense 3 *also* includes "stop" as a synonym.
            *   Let's look at the examples closer.
            *   Sense 1: "Quit teasing". This is stopping a behavior.
            *   Sense 3: "Stop the project". This is aborting a planned undertaking.
            *   "Treatment" is a planned undertaking. It is similar to a "project". Therefore, Sense 3 seems plausible.
            *   BUT, "discontinue" is very commonly associated with "cease" or "stop" generally.
            *   Let's look at the semantic domain. Sense 1 is general activity. Sense 3 often implies interruption (break/break off). "Discontinuation" of a drug is usually a cessation, not just an interruption (though it prevents completion).
            *   Let's check the hypernyms or hierarchy if possible. Sense 1 (`discontinue%2:42:00`) is often `stop`. Sense 3 (`discontinue%2:30:00`) is `prevent_completion`. The `2:30` domain often involves "stopping a process".
            *   Let's consider the "Quit teasing" vs "Stop the project".
                *   "Quit teasing": The teaser stops the action.
                *   "Stop the project": The agent stops the project.
                *   "Discontinue treatment": The agent stops the treatment.
            *   Is it Sense 1 or Sense 3? Let's look at the Sense 1 definition again: "put an end to a state or an activity".
            *   Let's look at Sense 3 again: "prevent completion".
            *   If I "discontinue" a line of products, I stop making them (Sense 1/2).
            *   If I "discontinue" a treatment, I stop giving it.
            *   The core meaning of "discontinue" is "to stop doing something".
            *   Sense 1 seems to be the default transitive "stop" sense.
            *   Sense 3 ("prevent completion") implies that the completion was the goal and it is thwarted. "Stop the project" prevents the project from finishing. "Discontinuing treatment" prevents the treatment course from finishing. This makes Sense 3 a strong candidate.
            *   However, many dictionaries define "discontinue" simply as "cease doing" or "stop". "Quit teasing" is stopping an activity. "Stop the project" is stopping an activity.
            *   Let's differentiate based on the synonyms "break/break off" in Sense 3. "Break off" usually implies discontinuing something that is continuous or a process (like negotiations). Treatment is a process. But "break" isn't the primary synonym for discontinuing a drug. "Stop" or "cease" are. Sense 1 has "stop, cease". Sense 3 has "break, break off".
            *   The synonyms in Sense 1 ("stop", "cease", "quit") are much more standard collocations for "discontinue treatment" than Sense 3's "break" or "break off". You don't usually say "The doctor broke off the treatment" (unless it was an IV line physically, or maybe negotiations). You say "The doctor stopped/ceased/discontinued the treatment".
            *   Therefore, Sense 1 is the better fit based on the synonyms "stop" and "cease".

3.  **Final Decision:**
    *   Context: "Treatment should be ... discontinued."
    *   Sense 1: "put an end to a state or an activity" (synonyms: stop, cease).
    *   Sense 3: "prevent completion" (synonyms: break, break off).
    *   "Ceasing" or "stopping" treatment fits Sense 1 perfectly. Sense 3's connotation of "breaking off" or specifically "preventing completion" (often implying an interruption or failure to complete) is slightly distinct. While stopping treatment prevents completion, the primary act is stopping the activity. The text highlights "delayed or discontinued", suggesting "stopped".
    *   Also, Sense 1 (`2:42`) is the "stative/active" change file. Sense 3 (`2:30`) is the "creation/physical" file (often used for stopping processes like manufacturing or projects).
    *   Actually, `2:42` (Sense 1) is usually the best choice for "stopping an action" (like teasing, or in this case, administering a drug).
    *   Wait, let me double check the sense key domain.
    *   Sense 1 (`discontinue%2:42:00`): 2:42 is `change`. Gloss: put an end to a state or an activity.
    *   Sense 3 (`discontinue%2:30:00`): 2:30 is `change`. Gloss: prevent completion.
    *   Example "Stop the project" maps to Sense 3.
    *   Example "Quit teasing" maps to Sense 1.
    *   Is treatment a "teasing" (behavior) or a "project" (undertaking)?
    *   It is an undertaking. However, "discontinue" is overwhelmingly associated with Sense 1 in standard usage for "discontinue service/drug/etc". Let's check the synonyms again.
    *   Sense 1: "stop", "cease".
    *   Sense 3: "break", "break off".
    *   "The treatment was discontinued." = "The treatment was stopped." (Sense 1 synonym).
    *   "The treatment was broken off." (Possible, but less idiomatic).
    *   Therefore, Sense 1 is selected. The synonymy with "stop" and "cease" confirms it.

    *   Refining the choice: Sense 2 is intransitive ("come to an end"). The sentence uses passive voice ("should be ... discontinued"), which corresponds to the transitive "discontinue" (someone stops it). So it's not Sense 2.
    *   Between Sense 1 and Sense 3: Sense 1 is the generic "stop". Sense 3 is "prevent completion" / "break off".
    *   Medical discontinuation is a cessation of administration. It fits "stop an activity" (Sense 1) perfectly. Sense 3 nuances lean towards "breaking off" negotiations or projects, often with a sense of interruption. While "discontinuing" a drug prevents the course from completing, the act itself is "stopping" the drug administration (the activity).
    *   Most WSD systems and dictionaries treat "discontinue" (transitive) primarily as "cease/stop". Sense 1 is the primary transitive sense.

    *   Result: Sense1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: dose
Target surface form: dose
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the <t>dose</t> reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=dose%1:06:00:: | definition=a measured portion of medicine taken at any one time | synonyms=dosage
2. sense_key=dose%1:23:00:: | definition=the quantity of an active agent (substance or radiation) taken in or absorbed at any one time | synonyms=dosage
3. sense_key=dose%1:26:00:: | definition=a communicable infection transmitted by sexual intercourse or genital contact | synonyms=venereal disease, VD, venereal infection, social disease, Cupid's itch, Cupid's disease
4. sense_key=dose%1:06:01:: | definition=street name for lysergic acid diethylamide | synonyms=acid, back breaker, battery-acid, dot, Elvis, loony toons

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the target word**: The target lemma is "dose", and the surface form is "dose". It appears in the phrase: "...the <t>dose</t> reduced, in patients whose blood counts are abnormal..."

2.  **Analyze the context**: The text is about the administration of a specific medication called "Alimta" (an anticancer chemotherapy drug).
    *   It discusses "recommended dose of Alimta is 500 mg".
    *   It mentions adjusting the "dose" based on side effects (blood counts).
    *   It mentions "cisplatin dose".
    *   The context is strictly medical/pharmaceutical, referring to a specific quantity of medication to be administered to a patient.

3.  **Evaluate candidate senses**:
    *   **Sense 1**: `dose%1:06:00::` - Definition: "a measured portion of medicine taken at any one time". Synonyms: "dosage".
        *   *Analysis*: This fits very well. Alimta is a medicine. The text discusses the quantity (500 mg/m²) and adjusting it. The definition explicitly mentions "medicine".
    *   **Sense 2**: `dose%1:23:00::` - Definition: "the quantity of an active agent (substance or radiation) taken in or absorbed at any one time". Synonyms: "dosage".
        *   *Analysis*: This is also a strong candidate. Chemotherapy drugs are active agents/substances. However, Sense 1 specifically mentions "medicine". In the WordNet hierarchy (ontology), Sense 1 (dose%1:06:00) is a hyponym of "medicine" (noun.artifact), while Sense 2 (dose%1:23:00) is a hyponym of "definite quantity" (noun.quantity) or related to "physical entity".
        *   Usually, WordNet distinguishes between the *concept* of the amount (Sense 2) and the *instance* or unit of the drug preparation (Sense 1).
        *   Let's look at the examples often associated with these senses.
            *   Sense 1 examples: "I took a dose of aspirin".
            *   Sense 2 examples: "The dose of radiation was high". Or "a dose of arsenic" (as a poison/agent).
        *   The context here is "the <t>dose</t> reduced". This refers to the measured amount of the medicinal drug Alimta. While Alimta is an active agent, the primary categorization in a clinical setting for "dose of Alimta" falls under "measured portion of medicine".
        *   Let's check the hierarchy.
            *   Sense 1 (`dose%1:06:00`) -> `dose` -> `medicinal_drug` -> ...
            *   Sense 2 (`dose%1:23:00`) -> `dose` -> `definite_quantity` -> ...
        *   Actually, let's look closer at the definitions.
            *   Sense 1: "measured portion of medicine".
            *   Sense 2: "quantity of an active agent (substance or radiation)".
        *   Alimta is a medicine. Therefore, Sense 1 is the most specific and accurate fit for "medicine". Sense 2 is broader (active agent) and often used for radiation or toxic substances, though "substance" covers drugs too. However, since "medicine" is explicitly mentioned in Sense 1, and the text is about "anticancer chemotherapy" (medicine), Sense 1 is preferred over the broader Sense 2.
        *   Wait, let's check if Sense 1 implies the *pill* itself or the *amount*. Definition says "measured portion".
        *   Let's re-read the text: "the recommended dose... is 500 mg". "the dose reduced". This refers to the quantity administered.
        *   WordNet 3.1 or 3.0 distinctions:
            *   `dose%1:06:00`: "a measured portion of medicine taken at any one time". Domain: noun.artifact (often implies the object, but definition is portion).
            *   `dose%1:23:00`: "the quantity of an active agent...". Domain: noun.quantity.
        *   Standard WSD usually prefers the more specific sense if applicable. Since Alimta is a "medicine", Sense 1 is more specific than Sense 2 (active agent).
        *   Many WSD datasets (like SemCor) tag medical drug dosages as Sense 1.
        *   Sense 3: "venereal disease". Clearly wrong.
        *   Sense 4: "LSD". Clearly wrong.

4.  **Refine between Sense 1 and Sense 2**:
    *   If I say "I need a dose of that medicine," I usually map to Sense 1.
    *   If I say "The radiation dose was 5 Gray," I map to Sense 2.
    *   Alimta is a medicine/drug. Sense 1 includes "medicine" in the gloss. Sense 2 includes "substance or radiation".
    *   Therefore, Sense 1 is the intended sense for a dose of a pharmaceutical drug.

5.  **Final Decision**: Sense 1 is the best fit.

    *   Sense 1: "measured portion of medicine" -> Matches Alimta (medicine).
    *   Sense 2: "quantity of an active agent" -> Matches active agents, often used for radiation or chemicals in a scientific context, but Sense 1 is the specialized medical sense.

    Result: Sense 1.

provider: DigitalOcean


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: reduce
Target surface form: reduced
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose <t>reduced</t>, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=reduce%2:30:00:: | definition=cut down on; make a reduction in | synonyms=cut down, cut back, trim, trim down, trim back, cut | examples=reduce your daily fat intake; The employer wants to cut back health benefits
2. sense_key=reduce%2:30:06:: | definition=make less complex | examples=reduce a problem to a single question
3. sense_key=reduce%2:41:00:: | definition=bring to humbler or weaker state or condition | examples=He reduced the population to slavery
4. sense_key=reduce%2:40:04:: | definition=simplify the form of a mathematical equation of expression by substituting one term for another
5. sense_key=reduce%2:37:00:: | definition=lower in grade or rank or force somebody into an undignified situation | examples=She reduced her niece to a servant
6. sense_key=reduce%2:30:11:: | definition=be the essential element | synonyms=come down, boil down | examples=The proposal boils down to a compromise
7. sense_key=reduce%2:30:05:: | definition=reduce in size; reduce physically | synonyms=shrink | examples=Hot water will shrink the sweater; Can you shrink this image?
8. sense_key=reduce%2:40:00:: | definition=lessen and make more modest | examples=reduce one's standard of living
9. sense_key=reduce%2:30:04:: | definition=make smaller | synonyms=scale down | examples=reduce an image
10. sense_key=reduce%2:30:03:: | definition=to remove oxygen from a compound, or cause to react with hydrogen or form a hydride, or to undergo an increase in the number of electrons | synonyms=deoxidize, deoxidise
11. sense_key=reduce%2:30:01:: | definition=narrow or limit | synonyms=tighten | examples=reduce the influx of foreigners
12. sense_key=reduce%2:41:03:: | definition=put down by force or intimidation | synonyms=repress, quash, keep down, subdue, subjugate | examples=The government quashes any attempt of an uprising; China keeps down her dissidents very efficiently
13. sense_key=reduce%2:35:00:: | definition=undergo meiosis | examples=The cells reduce
14. sense_key=reduce%2:35:01:: | definition=reposition (a broken bone after surgery) back to its normal site
15. sense_key=reduce%2:30:12:: | definition=destress and thus weaken a sound when pronouncing it
16. sense_key=reduce%2:30:08:: | definition=reduce in scope while retaining essential elements | synonyms=abridge, foreshorten, abbreviate, shorten, cut, contract | examples=The manuscript must be shortened
17. sense_key=reduce%2:30:10:: | definition=be cooked until very little liquid is left | synonyms=boil down, decoct, concentrate | examples=The sauce should reduce to one cup
18. sense_key=reduce%2:30:02:: | definition=cook until very little liquid is left | synonyms=boil down, concentrate | examples=The cook reduced the sauce by boiling it for a long time
19. sense_key=reduce%2:30:09:: | definition=lessen the strength or flavor of a solution or mixture | synonyms=dilute, thin, thin out, cut | examples=cut bourbon
20. sense_key=reduce%2:29:00:: | definition=take off weight | synonyms=melt off, lose weight, slim, slenderize, thin, slim down

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the target word and context:**
    *   **Target lemma:** reduce
    *   **Target surface form:** reduced
    *   **Context sentence:** "Treatment should be delayed or discontinued, or the dose **reduced**, in patients whose blood counts are abnormal or who have certain other side effects."
    *   **Broader context:** The text discusses a chemotherapy drug (Alimta), dosage (500 mg/m2), and how to manage side effects. Specifically, if patients have abnormal blood counts or side effects, the medical action taken might be to lower the amount of the drug administered.

2.  **Analyze the meaning in context:**
    *   The phrase "the dose reduced" means the amount of medication given to the patient is lowered or decreased.
    *   The goal is to make the quantity smaller to avoid toxicity or further harm.
    *   Synonyms relevant here: decrease, lower, diminish, cut down.

3.  **Evaluate the candidate senses:**

    *   **Sense 1:** `reduce%2:30:00::` | definition: cut down on; make a reduction in | examples: reduce your daily fat intake; The employer wants to cut back health benefits.
        *   *Analysis:* This sense refers to decreasing a quantity or amount (fat intake, health benefits). In the medical context, reducing a dose is making a reduction in the quantity of the drug. This fits well.

    *   **Sense 2:** `reduce%2:30:06::` | definition: make less complex | examples: reduce a problem to a single question.
        *   *Analysis:* Not about complexity. Incorrect.

    *   **Sense 3:** `reduce%2:41:00::` | definition: bring to humbler or weaker state or condition | examples: He reduced the population to slavery.
        *   *Analysis:* Metaphorical or sociological usage. Incorrect.

    *   **Sense 4:** `reduce%2:40:04::` | definition: simplify the form of a mathematical equation...
        *   *Analysis:* Mathematical usage. Incorrect.

    *   **Sense 5:** `reduce%2:37:00::` | definition: lower in grade or rank...
        *   *Analysis:* Hierarchical usage. Incorrect.

    *   **Sense 6:** `reduce%2:30:11::` | definition: be the essential element...
        *   *Analysis:* Abstract summarization. Incorrect.

    *   **Sense 7:** `reduce%2:30:05::` | definition: reduce in size; reduce physically | synonyms: shrink | examples: Hot water will shrink the sweater...
        *   *Analysis:* This implies physical contraction or shrinking of an object. While a dose is a physical entity in a way, "shrinking" usually refers to dimensions. Sense 1 is more abstractly about quantity/amount. However, is there a specific "lower the amount" sense?

    *   **Sense 8:** `reduce%2:40:00::` | definition: lessen and make more modest | examples: reduce one's standard of living.
        *   *Analysis:* Modest living standards. Close, but usually implies lifestyle or expectations.

    *   **Sense 9:** `reduce%2:30:04::` | definition: make smaller | synonyms: scale down | examples: reduce an image.
        *   *Analysis:* Making something smaller in scale or size.

    *   **Sense 10:** `reduce%2:30:03::` | definition: to remove oxygen... (chemistry).
        *   *Analysis:* Chemical context. Incorrect.

    *   **Sense 11:** `reduce%2:30:01::` | definition: narrow or limit | synonyms: tighten.
        *   *Analysis:* Restriction. Incorrect.

    *   **Sense 12:** `reduce%2:41:03::` | definition: put down by force...
        *   *Analysis:* Subjugation. Incorrect.

    *   **Sense 13:** `reduce%2:35:00::` | definition: undergo meiosis.
        *   *Analysis:* Biology (cell division). Incorrect.

    *   **Sense 14:** `reduce%2:35:01::` | definition: reposition (a broken bone...).
        *   *Analysis:* Medical, but orthopedic/surgical specific. Incorrect for dosage.

    *   **Sense 15:** `reduce%2:30:12::` | definition: destress and thus weaken a sound...
        *   *Analysis:* Phonetics. Incorrect.

    *   **Sense 16:** `reduce%2:30:08::` | definition: reduce in scope while retaining essential elements...
        *   *Analysis:* Editing/abridging. Incorrect.

    *   **Sense 17 & 18:** Cooking definitions.
        *   *Analysis:* Incorrect.

    *   **Sense 19:** `reduce%2:30:09::` | definition: lessen the strength or flavor of a solution or mixture.
        *   *Analysis:* While this involves a solution (medicine), "reducing a dose" usually means lowering the *quantity administered*, not diluting the concentration of the liquid itself (though sometimes related, the context "the dose reduced" implies the number of milligrams goes down, not that the specific ml of liquid is watered down).

    *   **Sense 20:** `reduce%2:29:00::` | definition: take off weight.
        *   *Analysis:* Dieting. Incorrect.

4.  **Select the best match:**
    *   Comparing Sense 1 ("cut down on; make a reduction in") and Sense 9 ("make smaller").
    *   Sense 1 examples: "reduce your daily fat intake" (quantity/amount), "cut back health benefits" (extent/quantity). This aligns perfectly with "reduce the dose" (lower the quantity/amount of medicine).
    *   Sense 9 examples: "reduce an image" (size/scale).
    *   Sense 1 is the general sense for decreasing a quantity or amount of something consumed or administered. "Reduce the dose" is synonymous with "cut down the dose".

    *   Let's re-verify Sense 1 vs Sense 9.
    *   Sense 1 gloss: "make a reduction in". Examples focus on intake and benefits (amounts/quantities).
    *   Sense 9 gloss: "make smaller". Examples focus on scaling (images).
    *   In medical contexts, "dose reduction" is the standard term for lowering the amount of drug. This aligns closest with the concept of "cutting down" or "making a reduction in" the amount. Sense 1 is the most appropriate standard WordNet sense for decreasing quantities like fat intake or doses.

    Therefore, Sense 1 is the correct choice.

    Refining the decision:
    Context: "the dose reduced".
    Meaning: The quantity of the drug is decreased.
    Sense 1 definition: "cut down on; make a reduction in".
    Examples: "reduce your daily fat intake".
    This matches the semantic field of adjusting quantities of substances/intake.

5.  **Final Output Generation:**
    *   Target sense index: 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in <t>patients</t> whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the Request:**
    *   Target lemma: "patient" (plural "patients").
    *   Context: A medical text describing the usage of the drug "Alimta" (pemetrexed). It discusses doctors, doses, side effects, kidney problems, etc.
    *   Candidate senses:
        1.  Sense 1 (patient%1:18:00::): "a person who requires medical care". Example: "the number of emergency patients has grown rapidly".
        2.  Sense 2 (patient%1:10:00::): "the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause". Synonyms: "affected role, patient role".
    *   Constraint: Choose the single best indexed sense. Return JSON `{"sense_index": X}`.

2.  **Analyze the Context:**
    *   The sentence containing the target word is: "Treatment should be delayed or discontinued, or the dose reduced, in <t>patients</t> whose blood counts are abnormal or who have certain other side effects."
    *   The broader context talks about "supervision of a doctor", "anticancer chemotherapy", "body surface area", "side effects", "kidney problems".
    *   The word "patients" refers to people receiving medical care (Alimta). They are the recipients of the treatment.

3.  **Evaluate Candidate Senses:**

    *   **Sense 1 (Medical Patient):**
        *   Definition: "a person who requires medical care".
        *   Fit: Perfect fit. The text describes people undergoing chemotherapy treatment for cancer. They are under a doctor's supervision, taking medicine, dealing with side effects. This matches the general noun definition of a patient in a hospital setting.

    *   **Sense 2 (Semantic Role):**
        *   Definition: "the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause".
        *   Fit: This is a linguistic/grammatical definition. It refers to the abstract concept of the "patient" role in semantic theory (distinct from agent, experiencer, etc.). While the people mentioned *are* semantic patients of the verb "treat" or "affect", the *word* usage here is the concrete noun referring to the person, not the abstract linguistic concept. In WordNet, sense 2 is usually the technical linguistic term. The context is a medical instruction leaflet, not a linguistics textbook.

4.  **Select the Best Sense:**
    *   The text describes actual people receiving medical care.
    *   Sense 1 matches the entity (the person).
    *   Sense 2 matches a theoretical linguistic construct.
    *   The target word "patients" refers to the group of people.
    *   Therefore, Sense 1 is the correct choice.

5.  **Format Output:**
    *   JSON format: `{"sense_index": 1}`.

    *   *Self-Correction/Double Check:* Is there any ambiguity?
        *   "patients" refers to the people.
        *   Sense 1: person who requires medical care.
        *   Context: "patients should take a corticosteroid", "patients with moderate or severe kidney problems".
        *   Unambiguously Sense 1.

provider: DeepInfra


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: blood_count
Target surface form: blood counts
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose <t>blood counts</t> are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=blood_count%1:23:00:: | definition=the number of red and white corpuscles in a blood sample
2. sense_key=blood_count%1:04:00:: | definition=the act of estimating the number of red and white corpuscles in a blood sample

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The user wants me to perform Word Sense Disambiguation (WSD) for the phrase "blood counts" in the provided context.
I need to choose between two candidate senses provided.

Target lemma: blood_count
Target surface form: blood counts

Context analysis:
The text describes the administration of the drug Alimta. It mentions side effects and conditions for delaying or discontinuing treatment. Specifically, it says: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose **blood counts** are abnormal or who have certain other side effects."

Candidate sense analysis:
1. Sense 1 (blood_count%1:23:00::): "the number of red and white corpuscles in a blood sample". This refers to the numerical value or the result of the measurement. "The count is low."
2. Sense 2 (blood_count%1:04:00::): "the act of estimating the number of red and white corpuscles in a blood sample". This refers to the procedure or action of counting.

Evaluating the context:
The sentence says "...patients whose **blood counts** are abnormal...".
Grammatically, "counts" here refers to the results (the numbers) of the test. If it referred to the act (Sense 2), it would likely be phrased differently (e.g., "patients whose blood counts indicate abnormalities" - though even then, it's usually the result). Saying "blood counts are abnormal" means the numerical values (white cell count, red cell count, platelets, etc.) are not within normal ranges.
If "blood count" referred to the act (Sense 2), we might say "the blood count was performed incorrectly".
Here, "abnormal" modifies the nature of the counts (the values). You don't say an act is "abnormal" in this specific medical context meaning the numerical result is off; you say the act was "improper" or the result is "abnormal".
Common usage in medical contexts: "Your blood counts are low/high/abnormal." This refers to the numbers.

Sense 1 fits the definition "the number of red and white corpuscles". It is a noun denoting the measurement result.
Sense 2 is an act. While the test is performed, the result is what matters for treatment decisions. "Whose blood counts are abnormal" implies possession of a specific status (the numbers).

Therefore, the correct sense is the one referring to the number/value.

Sense index mapping:
Sense 1 corresponds to index 1.
Sense 2 corresponds to index 2.

I need to output {"sense_index": 1}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: abnormal
Target surface form: abnormal
Context:
Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are <t>abnormal</t> or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems.

Candidate senses:
1. sense_key=abnormal%3:00:00:: | definition=not normal; not typical or usual or regular or conforming to a norm | synonyms=unnatural | examples=abnormal powers of concentration; abnormal amounts of rain
2. sense_key=abnormal%3:00:03:: | definition=departing from the normal in e.g. intelligence and development | examples=they were heartbroken when they learned their child was abnormal; an abnormal personality
3. sense_key=abnormal%5:00:00:immoderate:00 | definition=much greater than the normal | examples=abnormal profits; abnormal ambition

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the Target Word and Context:**
    *   Target Lemma: `abnormal`
    *   Context: A medical text about the drug "Alimta". The specific sentence is: "Treatment should be delayed or discontinued, or the dose <t>abnormal</t> or who have certain other side effects."
    *   Meaning in context: The phrase "blood counts are abnormal" refers to medical test results (blood cell counts) that fall outside the healthy or expected range. It implies a deviation from the standard physiological norm, indicating a potential health issue (side effect of the drug).

2.  **Analyze the Candidate Senses:**

    *   **Sense 1:** `abnormal%3:00:00::`
        *   Definition: "not normal; not typical or usual or regular or conforming to a norm"
        *   Synonyms: "unnatural"
        *   Examples: "abnormal powers of concentration"; "abnormal amounts of rain"
        *   Fit: This is the general, broad sense of "abnormal". Blood counts not conforming to the norm (healthy range) fits this definition perfectly. It applies to medical test results, weather, behavior, etc.

    *   **Sense 2:** `abnormal%3:00:03::`
        *   Definition: "departing from the normal in e.g. intelligence and development"
        *   Examples: "they were heartbroken when they learned their child was abnormal"; "an abnormal personality"
        *   Fit: This sense is specific to human attributes like intelligence, development, or personality. It often carries a connotation of a defect or disability in a person's growth or mind. While blood counts relate to health, this markers like blood counts. This is too specific and anthropocentric in the wrong way.

    *   **Sense 3:** `abnormal%5:00:00:immoderate:00`
        *   Definition: "much greater than the normal"
        *   Examples: "abnormal profits"; "abnormal ambition"
        *   Fit: This sense implies "excessive" or "immoderate". While abnormal blood counts can be high or low, the core meaning here is just "not normal" (could be high or low), not specifically "much greater". Also, Sense 3 is tagged as an adjective satellite (`%5`) implying it's a specific subsense of "immoderate". Blood counts being low (neutropenia, anemia) are just as "abnormal" in this context as them being high. The general sense (Sense 1) covers both high and low deviations.

3.  **Compare and Decide:**
    *   Sense 1 is the general definition ("not conforming to a norm").
    *   Sense 2 is specific to intelligence/development.
    *   Sense 3 is specific to being "much greater" (immoderate).

    The context describes "blood counts". In medicine, "abnormal" blood counts mean they deviate from the reference range. This fits Sense 1 best. Sense 2 is about people/development. Sense 3 is about magnitude/excess. Sense 1 captures the general deviation from a norm required for a medical test result.

4.  **Formulate Output:**
    *   The correct index is 1.
    *   Format: `{"sense_index": 1}`

provider: Amazon Bedrock