[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: see
Target surface form: see
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=see%2:39:00:: | definition=perceive by sight or have the power to perceive by sight | examples=You have to be a good observer to see all the details; Can you see the bird in that tree?
2. sense_key=see%2:31:01:: | definition=perceive (an idea or situation) mentally | synonyms=understand, realize, realise | examples=Now I see!; I just can't see your point
3. sense_key=see%2:39:02:: | definition=perceive or be contemporaneous with | synonyms=witness, find | examples=We found Republicans winning the offices; You'll see a lot of cheating in this school
4. sense_key=see%2:36:00:: | definition=imagine; conceive of; see in one's mind | synonyms=visualize, visualise, envision, project, fancy, figure | examples=I can't see him on horseback!; I can see what will happen
5. sense_key=see%2:31:00:: | definition=deem to be | synonyms=consider, reckon, view, regard | examples=She views this quite differently from me; I consider her to be shallow
6. sense_key=see%2:31:02:: | definition=get to know or become aware of, usually accidentally | synonyms=learn, hear, get word, get wind, pick up, find out | examples=I learned that she has two grown-up children; I see that you have been promoted
7. sense_key=see%2:39:03:: | definition=see or watch | synonyms=watch, view, catch, take in | examples=view a show on television; This program will be seen all over the world
8. sense_key=see%2:38:00:: | definition=come together | synonyms=meet, run into, encounter, run across, come across | examples=I'll probably see you at the meeting; How nice to see you again!
9. sense_key=see%2:32:00:: | definition=find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, find out, ascertain, watch, learn | examples=I want to see whether she speaks French; See whether it works
10. sense_key=see%2:31:03:: | definition=be careful or certain to do something; make certain of something | synonyms=check, insure, see to it, ensure, control, ascertain | examples=He verified that the valves were closed; See that the curtains are closed
11. sense_key=see%2:41:11:: | definition=go to see for professional or business reasons | examples=You should see a lawyer; We had to see a psychiatrist
12. sense_key=see%2:41:12:: | definition=go to see for a social visit | examples=I went to see my friend Mary the other day
13. sense_key=see%2:41:10:: | definition=go to see a place, as for entertainment | synonyms=visit | examples=We went to see the Eiffel Tower in the morning
14. sense_key=see%2:41:14:: | definition=take charge of or deal with | synonyms=attend, take care, look | examples=Could you see about lunch?; I must attend to this matter
15. sense_key=see%2:35:09:: | definition=receive as a specified guest | examples=the doctor will see you now; The minister doesn't see anybody before noon
16. sense_key=see%2:41:00:: | definition=date regularly; have a steady relationship with | synonyms=go steady, go out, date | examples=Did you know that she is seeing an older man?; He is dating his former wife again!
17. sense_key=see%2:39:05:: | definition=see and understand, have a good eye | examples=The artist must first learn to see
18. sense_key=see%2:31:08:: | definition=deliberate or decide | examples=See whether you can come tomorrow; let's see--which movie should we see tonight?
19. sense_key=see%2:39:11:: | definition=observe as if with an eye | examples=The camera saw the burglary and recorded it
20. sense_key=see%2:39:13:: | definition=observe, check out, and look over carefully or inspect | synonyms=examine | examples=The customs agent examined the baggage; I must see your passport before you can enter the country
21. sense_key=see%2:39:12:: | definition=go or live through | synonyms=experience, go through | examples=We had many trials to go through; he saw action in Viet Nam
22. sense_key=see%2:38:03:: | definition=accompany or escort | synonyms=escort | examples=I'll see you to the door
23. sense_key=see%2:33:00:: | definition=match or meet | examples=I saw the bet of one of my fellow players
24. sense_key=see%2:31:13:: | definition=make sense of; assign a meaning to | synonyms=interpret, construe | examples=What message do you see in this letter?; How do you interpret his behavior?

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The context is: "For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR)."

This is telling the reader to consult or look at another document for more information. It's a directive to find information by looking at a specific source.

Let me examine the candidate senses:

1. perceive by sight - not quite right, this is about consulting a document
2. perceive mentally - no, not about understanding
3. perceive or be contemporaneous with - no
4. imagine - no
5. deem to be - no
6. get to know or become aware of - no
7. see or watch - this could be close, about viewing something, but the examples are about shows/TV
8. come together/meet - no
9. find out, learn, or determine with certainty - this is about making an effort to discover something. The examples are "I want to see whether she speaks French; See whether it works"
10. be careful or certain to do something - no, this is about ensuring something
11. go to see for professional or business reasons - no
12. go to see for a social visit - no
13. go to see a place, as for entertainment - no
14. take charge of or deal with - no
15. receive as a specified guest - no
16. date regularly - no
17. see and understand, have a good eye - no
18. deliberate or decide - no
19. observe as if with an eye - no
20. observe, check out, and look over carefully or inspect - synonyms include "examine" - "The customs agent examined the baggage; I must see your passport before you can enter the country"
21. go or live through - no
22. accompany or escort - no
23. match or meet - no
24. make sense of; assign a meaning to - no

Hmm, let me think more carefully. The phrase "see the Summary of Product Characteristics" is telling the reader to consult/read/check a document for information.

Sense 9: "find out, learn, or determine with certainty, usually by making an inquiry or other effort" - this could work, but the examples are about checking whether something is true.

Sense 20: "observe, check out, and look over carefully or inspect" with synonym "examine" - this has the example "I must see your passport" which is similar in that it's about looking at a document/item.

Actually, let me reconsider. The usage "see [document]" meaning "consult [document]" or "refer to [document]" is quite common in formal/technical writing.

Looking at sense 7: "see or watch" with examples "view a show on television; This program will be seen all over the world" - this is about viewing/watching entertainment.

Looking at sense 20: "observe, check out, and look over carefully or inspect" with synonym "examine" - this is about examining something. The example "I must see your passport before you can enter the country" is similar - it's about consulting/checking a document.

I think sense 20 is the closest match. The meaning here is to examine, consult, or look over the Summary of Product Characteristics document for more information.

Actually, wait. Let me reconsider sense 9 again: "find out, learn, or determine with certainty, usually by making an inquiry or other effort" with synonyms "determine, check, find out, ascertain, watch, learn". The examples are about checking/investigating. But the context is more about consulting a reference document.

Looking at sense 20 more carefully: "observe, check out, and look over carefully or inspect" - this is about examining something. This seems to fit the idea of consulting/examining a document.

But actually, I'm wondering if there's a better fit. The phrase "For more information, see X" is essentially saying "consult X" or "look at X".

Hmm, none of the senses seem to perfectly capture this "consult a document" meaning. Let me look again...

Sense 7: "see or watch" with examples about viewing - this could work if we think of it as "look at" the document.

Sense 9: "find out, learn, or determine with certainty" - this is about investigation/inquiry.

Sense 20: "observe, check out, and look over carefully or inspect" - this is about examining.

I think sense 20 (examine) is the closest match, as consulting a document for information is a form of examining/inspecting it.

Actually, let me reconsider once more. The phrase "see the Summary of Product Characteristics" is essentially saying "consult this document." It's telling the reader to look at or examine the document for more information.

Sense 20 with synonym "examine" seems most appropriate here. The example "I must see your passport" is similar in that it's directing someone to look at a document for a specific purpose.

I'll go with sense 20.

Wait, actually I should reconsider sense 7 again. "see or watch" with synonyms "watch, view, catch, take in". This is about viewing/watching something. "For more information, see X" could be interpreted as "view X" or "look at X". But the examples are specifically about entertainment shows, which doesn't quite fit.

Sense 20 with "examine" seems more appropriate because the context is about consulting a reference document for information, which is more about examining/inspecting than just viewing.

I'll stick with sense 20.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: product
Target surface form: Product
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=product%1:06:01:: | definition=commodities offered for sale | synonyms=merchandise, ware | examples=good business depends on having good merchandise; that store offers a variety of products
2. sense_key=product%1:06:00:: | definition=an artifact that has been created by someone or some process | synonyms=production | examples=they improve their product every year; they export most of their agricultural production
3. sense_key=product%1:09:00:: | definition=a quantity obtained by multiplication | synonyms=mathematical product | examples=the product of 2 and 3 is 6
4. sense_key=product%1:27:00:: | definition=a chemical substance formed as a result of a chemical reaction | examples=a product of lime and nitric acid
5. sense_key=product%1:19:00:: | definition=a consequence of someone's efforts or of a particular set of circumstances | examples=skill is the product of hours of practice; his reaction was the product of hunger and fatigue
6. sense_key=product%1:14:00:: | definition=the set of elements common to two or more sets | synonyms=intersection, Cartesian product | examples=the set of red hats is the intersection of the set of hats and the set of red things

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

finish_reason: stop

content:
```json
{"sense_index": 2}
```

role: assistant

reasoning_content:
The target word is "Product" in the phrase "Summary of Product Characteristics".
This phrase refers to a pharmaceutical product (medicinal product), which is a specific type of artifact that has been created by someone or some process (or a commodity offered for sale).
Let's evaluate the senses:
1. commodities offered for sale (merchandise, ware) - applicable to pharmaceuticals, but "Summary of Product Characteristics" is a regulatory document about a medical product (an artifact/creation).
2. an artifact that has been created by someone or some process (production) - "Alimta" is a product created by a pharmaceutical company.
3. a quantity obtained by multiplication - irrelevant.
4. a chemical substance formed as a result of a chemical reaction - Alimta is a drug, but the "Summary of Product Characteristics" refers to the pharmaceutical product (the drug) as a whole, which is an artifact/preparation.
5. a consequence of someone's efforts - irrelevant.
6. the set of elements common to two or more sets - irrelevant.

Wait, "Summary of Product Characteristics" (SmPC) is the official EU term for the document that describes a medicinal product. The "product" here is the medicinal product (Alimta).
Sense 1: commodities offered for sale. Synonyms: merchandise, ware.
Sense 2: an artifact that has been created by someone or some process. Synonyms: production.

Is a medicinal product better captured as a commodity offered for sale, or an artifact created by a process? "Summary of Product Characteristics" is about the manufactured drug (an artifact created by some process). "Artifact that has been created by someone or some process" fits the pharmaceutical preparation (Alimta) perfectly.

Let's re-read sense 1 and 2.
Sense 1: commodities offered for sale. "that store offers a variety of products"
Sense 2: an artifact that has been created by someone or some process. "they improve their product every year"
A pharmaceutical product is a manufactured artifact. Sense 2 seems more fitting because it encompasses the manufactured nature of the drug (artifact), whereas sense 1 emphasizes it being merchandise. Alimta is an artifact created by a pharmaceutical company.

Let's look closely at sense 2: "an artifact that has been created by someone or some process". A medicinal product is definitely an artifact created by a process.

Let's look at sense 1: "commodities offered for sale". While Alimta is sold, the "Summary of Product Characteristics" refers to the medicinal product's characteristics (composition, clinical particulars, etc.), treating it more as an artifact of a manufacturing process rather than just merchandise.

I will choose sense 2.

format: unknown

native_finish_reason: stop

provider: SiliconFlow

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: part
Target surface form: part
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=part%1:24:00:: | definition=something determined in relation to something that includes it | synonyms=portion, component part, component, constituent | examples=he wanted to feel a part of something bigger than himself; I read a portion of the manuscript
2. sense_key=part%1:06:00:: | definition=something less than the whole of a human artifact | synonyms=portion | examples=the rear part of the house; glue the two parts together
3. sense_key=part%1:17:00:: | definition=a portion of a natural object | synonyms=piece | examples=they analyzed the river into three parts; he needed a piece of granite
4. sense_key=part%1:09:02:: | definition=that which concerns a person with regard to a particular role or situation | examples=it requires vigilance on our part; they resisted every effort on his part
5. sense_key=part%1:15:00:: | definition=the extended spatial location of something | synonyms=region | examples=the farming regions of France; religions in all parts of the world
6. sense_key=part%1:04:01:: | definition=the actions and activities assigned to or required or expected of a person or group | synonyms=function, office, role | examples=the function of a teacher; the government must do its part
7. sense_key=part%1:09:01:: | definition=an actor's portrayal of someone in a play | synonyms=character, role, theatrical role, persona | examples=she played the part of Desdemona
8. sense_key=part%1:21:00:: | definition=assets belonging to or due to or contributed by an individual person or group | synonyms=share, portion, percentage | examples=he wanted his share in cash
9. sense_key=part%1:09:00:: | definition=one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division | examples=the written part of the exam; the finance section of the company
10. sense_key=part%1:08:01:: | definition=a line of scalp that can be seen when sections of hair are combed in opposite directions | synonyms=parting | examples=his part was right in the middle
11. sense_key=part%1:10:00:: | definition=the melody carried by a particular voice or instrument in polyphonic music | synonyms=voice | examples=he tried to sing the tenor part
12. sense_key=part%1:04:03:: | definition=the part played by a person in bringing about a result | synonyms=contribution, share | examples=I am proud of my contribution in advancing the project; they all did their share of the work

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
The target word is "part" in the phrase: "For more information, see the Summary of Product Characteristics (also part of the EPAR)."

Let me analyze the context:
- The phrase is "also part of the EPAR"
- EPAR stands for European Public Assessment Report (a regulatory document for medicines)
- The Summary of Product Characteristics is described as being a component/portion of the larger EPAR document
- This refers to something being a component or portion of a larger whole (the EPAR)

Let me look at the candidate senses:

1. "something determined in relation to something that includes it" - synonyms: portion, component part, component, constituent - examples: "he wanted to feel a part of something bigger than himself"

2. "something less than the whole of a human artifact" - synonyms: portion - examples: "the rear part of the house"

3. "a portion of a natural object" - synonyms: piece - doesn't fit, EPAR is a document (artifact), not a natural object

4. "that which concerns a person with regard to a particular role or situation" - doesn't fit

5. "the extended spatial location of something" - doesn't fit

6. "the actions and activities assigned to or required or expected of a person or group" - doesn't fit

7. "an actor's portrayal of someone in a play" - doesn't fit

8. "assets belonging to or due to or contributed by an individual person or group" - doesn't fit

9. "one of the portions into which something is regarded as divided and which together constitute a whole" - synonyms: section, division - examples: "the written part of the exam"

10. "a line of scalp that can be seen when sections of hair are combed in opposite directions" - doesn't fit

11. "the melody carried by a particular voice or instrument in polyphonic music" - doesn't fit

12. "the part played by a person in bringing about a result" - doesn't fit

The main contenders are:
- Sense 1: "something determined in relation to something that includes it" - general component/part sense
- Sense 2: "something less than the whole of a human artifact" - specifically about artifacts
- Sense 9: "one of the portions into which something is regarded as divided and which together constitute a whole"

The EPAR is a human artifact (a document), and the Summary of Product Characteristics is a section/part of it.

Sense 1 seems most appropriate because:
- It's the most general "component part" sense
- "also part of the EPAR" matches the structure "part of something that includes it"
- The example "he wanted to feel a part of something bigger than himself" uses the same prepositional phrase structure

Sense 2 specifically mentions "human artifact" which fits (EPAR is a document), but the examples are more about physical objects like houses.

Sense 9 mentions "portions into which something is regarded as divided" with synonyms like "section, division" - this could also fit since the Summary of Product Characteristics is like a section of the EPAR.

However, I think Sense 1 is the best match because:
- It's the most general sense of "part" meaning a component or portion
- The phrase "part of the EPAR" matches the definition "something determined in relation to something that includes it"
- The synonyms "portion, component part, component, constituent" are appropriate for this context

Actually, let me reconsider. The phrase is saying that the Summary of Product Characteristics is a constituent/component of the EPAR. This is about something being a component part of a larger document.

Sense 1: "something determined in relation to something that includes it" - this is the general abstract sense of being part of something
Sense 9: "one of the portions into which something is regarded as divided and which together constitute a whole" - this emphasizes division into sections

Both could work, but Sense 1 seems more appropriate for the abstract "part of" relationship, while Sense 9 seems more about specific divisions or sections.

I'll go with Sense 1 as the best match.

provider: AtlasCloud


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
7. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
13. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the target word**: The target is "active" in the phrase "The active substance in Alimta..." and later "...converted into an active form that blocks the activity...".

2.  **Analyze the context**: The text describes a medicine (Alimta) and its mechanism of action. The phrase "active substance" refers to the ingredient that causes the medical effect. Similarly, an "active form" of the chemical is one that produces the pharmacological effect (blocking enzymes).

3.  **Evaluate the candidate senses**:
    *   Sense 1: "tending to become more severe or wider in scope" (e.g., active tuberculosis). Not relevant to a chemical substance in medicine.
    *   Sense 2: "engaged in or ready for military or naval operations". Irrelevant.
    *   Sense 3: "disposed to take action or effectuate change". Refers to people/agents with will/intent usually, not chemical ingredients.
    *   Sense 4: "taking part in an activity". Refers to people.
    *   Sense 5: "characterized by energetic activity". Refers to movement/liveliness.
    *   Sense 6: "exerting influence or producing a change or effect". Example given: "an active ingredient". This matches the context perfectly. "Active substance" is synonymous with "active ingredient".
    *   Sense 7: "full of activity or engaged in continuous activity". Refers to places/markets.
    *   Sense 8: "in operation". Synonym: "alive". While it is "in operation" in a sense, sense 6 is specific to producing an effect/ingredient, which is the standard pharmaceutical terminology.
    *   Sense 9: Solar activity. Irrelevant.
    *   Sense 10: Grammatical voice. Irrelevant.
    *   Sense 11: Verbs/adjectives expressing action. Irrelevant.
    *   Sense 12/13: Volcanos. Irrelevant.
    *   Sense 14: Full-time work. Irrelevant.

4.  **Select the best sense**: Sense 6 explicitly defines "active" as "exerting influence or producing a change or effect" and uses "an active ingredient" as the example. The context mentions "active substance" (synonymous with active ingredient) and a form that "blocks the activity" (produces an effect).

5.  **Determine the index**: The senses are numbered 1 through 14 in the list provided.
    *   1 -> active%3:00:02::
    *   2 -> active%5:00:00:operational:00
    *   3 -> active%3:00:03::
    *   4 -> active%5:00:00:involved:00
    *   5 -> active%3:00:01::
    *   6 -> active%3:00:07:: (Definition: exerting influence or producing a change or effect)

    Let's double check the list numbering in the prompt.
    1. sense_key=active%3:00:02:: | definition=tending to become more severe...
    2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military...
    3. sense_key=active%3:00:03:: | definition=disposed to take action...
    4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity...
    5. sense_key=active%3:00:01:: | definition=characterized by energetic activity...
    6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient

    The target text says "The active substance in Alimta". This is the component that does the work (produces the change/effect).
    Sense 6 is the correct definition and matches the example "an active ingredient".

    Therefore, the index is 6.

provider: DigitalOcean


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: substance
Target surface form: substance
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=substance%1:03:00:: | definition=the real physical matter of which a person or thing consists | examples=DNA is the substance of our genes
2. sense_key=substance%1:09:01:: | definition=the choicest or most essential or most vital part of some idea or experience | synonyms=kernel, core, center, centre, essence, gist | examples=the gist of the prosecutor's argument; the heart and soul of the Republican Party
3. sense_key=substance%1:09:00:: | definition=the idea that is intended | synonyms=meaning | examples=What is the meaning of this proverb?
4. sense_key=substance%1:27:00:: | definition=material of a particular kind or constitution | examples=the immune response recognizes invading substances
5. sense_key=substance%1:21:00:: | definition=considerable capital (wealth or income) | synonyms=means | examples=he is a man of means
6. sense_key=substance%1:10:00:: | definition=what a communication that is about something is about | synonyms=message, content, subject matter
7. sense_key=substance%1:03:01:: | definition=a particular kind or species of matter with uniform properties | examples=shigella is one of the most toxic substances known to man

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 7}
```

content:
```json
{"sense_index": 7}
```

reasoning_content:
1.  **Analyze the Target Word and Context**:
    *   Target word: "substance" (lemma: substance).
    *   Context: "The active *substance* in Alimta, pemetrexed, is a cytotoxic medicine..."
    *   The sentence is discussing a pharmaceutical product (Alimta). It refers to the "active substance" inside the medicine.
    *   In pharmacology, an "active substance" is the chemical ingredient responsible for the drug's effect.

2.  **Analyze the Candidate Senses**:

    *   *Sense 1*: `substance%1:03:00::` -> "the real physical matter of which a person or thing consists". Example: "DNA is the substance of our genes". This is a very general definition of physical matter. While pemetrexed is physical matter, the specific phrase "active substance" usually refers to a specific chemical entity with uniform properties, not just "matter" in a general sense.

    *   *Sense 2*: `substance%1:09:01::` -> "the choicest or most essential or most vital part of some idea or experience". Synonyms: kernel, core, essence. This is an abstract meaning. The context is physical/chemical. Incorrect.

    *   *Sense 3*: `substance%1:09:00::` -> "the idea that is intended". Synonyms: meaning. Abstract. Incorrect.

    *   *Sense 4*: `substance%1:27:00::` -> "material of a particular kind or constitution". Example: "the immune response recognizes invading substances". This fits well. Pemetrexed is a material of a particular kind.

    *   *Sense 5*: `substance%1:21:00::` -> "considerable capital (wealth or income)". Synonyms: means. Context is financial/wealth. Incorrect.

    *   *Sense 6*: `substance%1:10:00::` -> "what a communication that is about something is about". Synonyms: message, content. Abstract. Incorrect.

    *   *Sense 7*: `substance%1:03:01::` -> "a particular kind or species of matter with uniform properties". Example: "shigella is one of the most toxic substances known to man".
        *   Let's compare Sense 4 and Sense 7.
        *   Sense 4: "material of a particular kind or constitution". Example: "invading substances".
        *   Sense 7: "a particular kind or species of matter with uniform properties". Example: "toxic substances".
        *   Both fit the general notion of a chemical/drug.
        *   However, Sense 7 is often the standard WordNet definition for chemical substances or drugs. "Active substance" implies a specific chemical entity with defined properties.
        *   Let's look at the specific nuances.
        *   Sense 1 is very broad physical matter.
        *   Sense 7 is a specific kind of matter with uniform properties (chemistry definition).
        *   Sense 4 is often used for materials or mixtures.
        *   In pharmaceutical contexts, an "active substance" is a specific chemical compound.
        *   Let's check the hierarchy or common usage mapping.
        *   WordNet 3.1:
            *   substance (n) 1: the real physical matter of which a person or thing consists. (Sense 1 here).
            *   substance (n) 2: the substance of a living cell... (sometimes merged).
            *   substance (n) 3: a particular kind or species of matter with uniform properties. (Sense 7 here).
            *   substance (n) 4: material of a particular kind or constitution. (Sense 4 here).
        *   Pemetrexed is a specific chemical compound. Therefore, Sense 7 ("a particular kind or species of matter with uniform properties") is the most precise scientific definition for a drug component. Sense 4 is slightly more generic ("material of a particular kind"), often used for things like "sticky substance" or "hazardous substance" in a less strictly defined chemical sense, though they overlap heavily.
        *   The example for Sense 7 is "shigella is one of the most toxic substances known to man". This aligns with biological/chemical agents.
        *   The example for Sense 4 is "the immune response recognizes invading substances".
        *   The text says "The active substance in Alimta, pemetrexed". Pemetrexed is a specific chemical species. Sense 7 is the definition for "chemical substance".

    *   Let's re-evaluate Sense 1. "the real physical matter of which a person or thing consists". This is usually contrasted with spirit or form, or used for "substance of the protoplasm". Not the best fit for a specific drug ingredient.

    *   Let's compare Sense 4 and Sense 7 again.
        *   Sense 7: "a particular kind or species of matter with uniform properties". This is the definition of a chemical substance. Pemetrexed is a chemical substance.
        *   Sense 4: "material of a particular kind or constitution". This is close, but Sense 7 is the standard definition for "substance" in a chemical/pharmacological context.

    *   Let's look at the examples provided in the prompt again.
        *   Sense 7 Example: "shigella is one of the most toxic substances known to man". This refers to a specific biological/chemical agent. Pemetrexed is a specific chemical agent.
        *   Sense 4 Example: "the immune response recognizes invading substances". This treats substances as objects of a reaction.

    *   Sense 7 seems to be the specific hypernym for chemical compounds in WordNet (often linked to `chemical` or `matter`).
    *   In the European Medicines Agency context (EPAR mentioned in text), "active substance" is a formal term for the active pharmaceutical ingredient (API).
    *   API = a specific chemical entity.
    *   Definition: "a particular kind or species of matter with uniform properties". This fits perfectly.

    *   Let's double check the indexing in the prompt list.
        *   Index 7 corresponds to `substance%1:03:01::`.
        *   Wait, let's look at the sense keys provided.
        *   Sense 1: `substance%1:03:00::` (physical matter)
        *   Sense 7: `substance%1:03:01::` (particular kind/species of matter)
        *   Sense 4: `substance%1:27:00::` (material of a particular kind)

    *   The distinction between Sense 4 and Sense 7 is crucial here.
    *   Sense 7 (Sense key ...01::) is the chemical substance sense.
    *   Sense 4 (Sense key ...27:00::) is slightly broader material sense?
    *   Actually, in WordNet 3.0/3.1:
        *   `substance%1:03:00::` is the top node "physical matter".
        *   `substance%1:03:01::` is the hyponym "chemical substance" (a particular kind...).
        *   The text refers to "active substance", which is a technical term for a specific chemical entity.
        *   Therefore, Sense 7 is the correct choice. It defines "substance" as a specific kind of matter, which is exactly what pemetrexed is.

3.  **Final Verification**:
    *   Context: "The active substance... pemetrexed..."
    *   Pemetrexed is a specific molecule.
    *   Sense 7: "a particular kind or species of matter with uniform properties".
    *   This is the definition of a chemical substance.
    *   Sense 4 is "material of a particular kind or constitution". This is often used for things like "a sticky substance" or "radioactive substance". While pemetrexed is a substance in that sense too, Sense 7 is the more specific, technical definition corresponding to "chemical substance" or "drug substance". The example "toxic substances" supports the chemical/biological agent reading.
    *   Sense 1 is too general (matter itself vs specific kind of matter).

    *   Therefore, Index 7 is the best fit.

provider: Baidu


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the target word and context:**
    *   Target lemma: "medicine"
    *   Target surface form: "medicine"
    *   Context snippet: "...pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing...)"
    *   The context describes a specific substance (pemetrexed) being referred to as a "medicine". It mentions it treats cancer (kills cells).

2.  **Analyze the candidate senses:**

    *   **Sense 1:** "the branches of medical science that deal with nonsurgical techniques" (Synonyms: medical specialty).
        *   *Context match?* No. The text refers to a specific substance (pemetrexed), not a branch of science or study.

    *   **Sense 2:** "(medicine) something that treats or prevents or alleviates the symptoms of disease" (Synonyms: medication, medicament, medicinal drug).
        *   *Context match?* Yes. The text refers to "Alimta" and "pemetrexed" as a "medicine". It says it "kills cells... such as cancer cells", implying it treats disease. The synonym "medication" fits perfectly with the earlier mention of "anti-emetic medicine". This sense refers to a substance/drug.

    *   **Sense 3:** "the learned profession that is mastered by graduate training in a medical school..." (Synonyms: practice of medicine).
        *   *Context match?* No. The text is not referring to the profession or the field of study (e.g., "he studied medicine"). It refers to a physical object/substance administered to a patient.

    *   **Sense 4:** "punishment for one's actions" (Synonyms: music).
        *   *Context match?* No. This is an idiomatic sense ("take your medicine"). The context is medical/pharmaceutical.

3.  **Select the best sense:**
    *   Sense 2 defines "medicine" as a substance used to treat disease (synonyms: medication, drug).
    *   The context describes pemetrexed as a "cytotoxic medicine" used to kill cancer cells. This aligns perfectly with Sense 2.

4.  **Format the output:**
    *   The user wants a JSON object `{"sense_index": X}`.
    *   The chosen sense corresponds to index 2.

    *   Wait, let me double-check the indexing.
    *   Sense 1: branches of medical science.
    *   Sense 2: substance/drug.
    *   Sense 3: profession.
    *   Sense 4: punishment.

    *   The target "cytotoxic medicine" refers to a substance.
    *   Sense 2 is "something that treats or prevents...".
    *   Therefore, sense_index is 2.

5.  **Final Output Generation:**
    *   JSON: `{"sense_index": 2}`.

provider: Together


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the target word and context:**
    *   Target lemma: medicine
    *   Target surface form: medicine
    *   Context snippet: "...pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells)..."
    *   The context is describing a specific substance (pemetrexed/Alimta) used to treat cancer. It is referred to as a "cytotoxic medicine" and defined as something that "kills cells".

2.  **Analyze the candidate senses:**
    *   Sense 1: "the branches of medical science that deal with nonsurgical techniques". Synonyms: medical specialty. (e.g., "He practices medicine"). This refers to a field of study or practice, not a physical substance.
    *   Sense 2: "(medicine) something that treats or prevents or alleviates the symptoms of disease". Synonyms: medication, medicament, medicinal drug. This refers to a substance/drug.
    *   Sense 3: "the learned profession that is mastered by graduate training...". Synonyms: practice of medicine. Example: "he studied medicine at Harvard". This refers to the profession or field of study.
    *   Sense 4: "punishment for one's actions". Synonyms: music. Idiomatic usage ("take your medicine").

3.  **Match context to senses:**
    *   The context explicitly defines the target word as "a medicine that kills cells that are dividing".
    *   Pemetrexed is a specific drug/substance.
    *   Sense 2 is the definition of a drug/medicinal substance.
    *   Senses 1 and 3 refer to the field/profession.
    *   Sense 4 is an idiom unrelated to pharmacology.

4.  **Conclusion:**
    *   The target word refers to a specific medicinal substance (a drug).
    *   Sense 2 corresponds to "medication" or "medicinal drug".
    *   Therefore, Sense 2 is the correct choice.

5.  **Format Output:**
    *   The instruction asks for a JSON object: {"sense_index": X}.
    *   The chosen index is 2.

provider: Novita


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: kill
Target surface form: kills
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=kill%2:35:00:: | definition=cause to die; put to death, usually intentionally or knowingly | examples=This man killed several people when he tried to rob a bank; The farmer killed a pig for the holidays
2. sense_key=kill%2:41:01:: | definition=thwart the passage of | synonyms=shoot down, defeat, vote down, vote out | examples=kill a motion; he shot down the student's proposal
3. sense_key=kill%2:30:08:: | definition=end or extinguish by forceful means | synonyms=stamp out | examples=Stamp out poverty!
4. sense_key=kill%2:42:00:: | definition=be fatal | examples=cigarettes kill; drunken driving kills
5. sense_key=kill%2:39:00:: | definition=be the source of great pain for | examples=These new shoes are killing me!
6. sense_key=kill%2:37:00:: | definition=overwhelm with hilarity, pleasure, or admiration | examples=The comedian was so funny, he was killing me!
7. sense_key=kill%2:35:06:: | definition=hit with so much force as to make a return impossible, in racket games | examples=She killed the ball
8. sense_key=kill%2:35:05:: | definition=hit with great force | examples=He killed the ball
9. sense_key=kill%2:35:02:: | definition=deprive of life | examples=AIDS has killed thousands in Africa
10. sense_key=kill%2:35:01:: | definition=cause the death of, without intention | examples=She was killed in the collision of three cars
11. sense_key=kill%2:34:00:: | definition=drink down entirely | synonyms=toss off, pop, bolt down, belt down, pour down, down | examples=He downed three martinis before dinner; She killed a bottle of brandy that night
12. sense_key=kill%2:30:00:: | definition=mark for deletion, rub off, or erase | synonyms=obliterate, wipe out | examples=kill these lines in the President's speech
13. sense_key=kill%2:30:04:: | definition=tire out completely | examples=The daily stress of her work is killing her
14. sense_key=kill%2:30:03:: | definition=cause to cease operating | examples=kill the engine
15. sense_key=kill%2:30:02:: | definition=destroy a vitally essential quality of or in | examples=Eating artichokes kills the taste of all other foods

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the Context:**
    *   Sentence: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells)..."
    *   Subject: "medicine" / "active substance" / "pemetrexed".
    *   Object: "cells that are dividing, such as cancer cells".
    *   Meaning: The medicine causes the cancer cells to die. It destroys them biologically. This is the primary mechanism of cytotoxic drugs.

2.  **Analyze the Candidate Senses:**
    *   1: `kill%2:35:00::` - "cause to die; put to death, usually intentionally or knowingly". Examples: murder, pig slaughter. Fits "cause to die", but usually implies an agent (like a person) intentionally killing another person/animal.
    *   2: `kill%2:41:01::` - "thwart the passage of". Metaphorical. Not applicable.
    *   3: `kill%2:30:08::` - "end or extinguish by forceful means". Metaphorical (stamp out poverty). Not quite right for biological cell death.
    *   4: `kill%2:42:00::` - "be fatal". Intransitive. Examples: "cigarettes kill". The context uses "kills cells" (transitive).
    *   5: `kill%2:39:00::` - "be the source of great pain for". Idiomatic. Not applicable.
    *   6: `kill%2:37:00::` - "overwhelm with hilarity...". Idiomatic. Not applicable.
    *   7: `kill%2:35:06::` - racket games. Not applicable.
    *   8: `kill%2:35:05::` - hit with great force. Not applicable.
    *   9: `kill%2:35:02::` - "deprive of life". Example: "AIDS has killed thousands in Africa". This fits well. It describes causing death on a large scale or by a process/disease/agent, without the specific "put to death" intentional nuance of sense 1. It covers the biological causation of death.
    *   10: `kill%2:35:01::` - "cause the death of, without intention". Example: car collision. Not applicable to medicine acting intentionally on cancer.
    *   11: `kill%2:34:00::` - drink entirely. Not applicable.
    *   12: `kill%2:30:00::` - mark for deletion. Not applicable.
    *   13: `kill%2:30:04::` - tire out completely. Not applicable.
    *   14: `kill%2:30:03::` - cause to cease operating. Not applicable.
    *   15: `kill%2:30:02::` - destroy a vitally essential quality. Not applicable.

3.  **Compare Sense 1 and Sense 9:**
    *   Sense 1: "cause to die; put to death, usually intentionally or knowingly". Examples focus on human agency (robbery, farmer). While the drug is intended to kill cancer, WordNet distinguishes specific types of killing.
    *   Sense 9: "deprive of life". Example: "AIDS has killed thousands". This sense is often used for diseases, processes, or things that cause death as a function of their nature. Pemetrexed (the medicine) acts like a disease or a force that deprives cells of life. The example "AIDS has killed..." parallels "medicine kills cells".
    *   Let's look closer at the hierarchy or distinction.
        *   Sense 1 emphasizes "put to death, usually intentionally". This usually implies a sentient agent doing the killing (murder, execution).
        *   Sense 9 is "deprive of life". This is the general biological definition. Drugs, diseases, and natural phenomena generally fall here.
    *   The context is "a medicine that kills cells". The drug deprives the cells of life.
    *   Does the distinction between "put to death" (Sense 1) and "deprive of life" (Sense 9) hinge on the agent? Sense 1 examples involve human agents. Sense 9 example involves a disease (AIDS).
    *   A medicine is an agent, but it acts biologically. The context is scientific/medical.
    *   Sense 9 seems the most appropriate for a cytotoxic substance causing cell death, similar to how a disease causes death.

4.  **Verify Sense 9:**
    *   Definition: "deprive of life".
    *   Example: "AIDS has killed thousands in Africa".
    *   Context: "pemetrexed... kills cells".
    *   This fits perfectly. It describes the biological cessation of life caused by an agent/substance.

5.  **Final Decision:** Sense 9 is the best match. Sense 1 is too specific to human/sentient agency (homicide/slaughter). Sense 4 is intransitive. Sense 10 is accidental. Sense 9 is the general transitive "cause to die" for non-human or quasi-agents (like diseases, drugs).

    Wait, let me double-check Sense 1 vs 9.
    Sense 1: "cause to die; put to death..." (Examples: man killed people, farmer killed pig).
    Sense 9: "deprive of life" (Example: AIDS has killed...).
    The target is a medicine. Is a medicine closer to a human agent or a disease agent?
    In WordNet annotation practices (e.g., SemCor), Sense 1 is usually for sentient agents. Sense 9 is for events, situations, or inanimate agents that result in death.
    Therefore, the medicine falls under Sense 9.

    Let's check index.
    Sense 1 is index 1.
    Sense 9 is index 9.

    Let's re-read Sense 1 definition: "cause to die; put to death, usually intentionally or knowingly".
    While the doctor prescribes it intentionally, the *medicine* itself acts as the instrument.
    Sense 9 definition: "deprive of life".
    This is the most neutral and scientifically accurate definition for a chemical causing cell death.

    Therefore, Sense 9.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cells
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the Target:** The target word is "cells" (plural noun), the surface form of "cell".
2.  **Analyze the Context:** The context is a medical text describing the drug Alimta (pemetrexed).
    *   "Alimta... is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells)..."
    *   "...genetic material of cells."
3.  **Analyze the Candidate Senses:**
    *   Sense 1: "any small compartment" (e.g., honeycomb). Too generic.
    *   Sense 2: "(biology) the basic structural and functional unit of all organisms..." This fits the biological context perfectly. The text talks about cancer cells, dividing cells, and genetic material (DNA/RNA) within cells.
    *   Sense 3: "a device that delivers an electric current..." (Electric cell). Not relevant.
    *   Sense 4: "a small unit serving as part of... a political movement". Not relevant.
    *   Sense 5: "a hand-held mobile radiotelephone..." (Cell phone). Not relevant.
    *   Sense 6: "small room in which a monk or nun lives". Not relevant.
    *   Sense 7: "a room where a prisoner is kept". Not relevant.
4.  **Select the Best Sense:** Sense 2 is the biological definition. The context explicitly mentions "cancer cells" and "genetic material of cells" and "dividing". This aligns exactly with the definition of biological cells.
5.  **Format Output:** The user wants a JSON object `{"sense_index": X}` where X is the index number (1-based).

    *   Index 1 corresponds to sense_key=cell%1:06:03:: (compartment).
    *   Index 2 corresponds to sense_key=cell%1:03:00:: (biology unit).
    *   Index 3 corresponds to sense_key=cell%1:06:00:: (electric cell).
    *   Index 4 corresponds to sense_key=cell%1:14:00:: (political unit).
    *   Index 5 corresponds to sense_key=cell%1:06:04:: (mobile phone).
    *   Index 6 corresponds to sense_key=cell%1:06:02:: (monk's room).
    *   Index 7 corresponds to sense_key=cell%1:06:01:: (prison cell).

    The correct index is 2.

provider: StreamLake


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: divide
Target surface form: dividing
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=divide%2:41:00:: | definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire after World War I
2. sense_key=divide%2:31:00:: | definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven?
3. sense_key=divide%2:42:00:: | definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries
4. sense_key=divide%2:35:00:: | definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated
5. sense_key=divide%2:38:00:: | definition=make a division or separation | synonyms=separate
6. sense_key=divide%2:35:01:: | definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

content:
```json
{"sense_index": 1}
```

reasoning_content:
1.  **Analyze the target word and context:**
    *   Target lemma: divide
    *   Target surface form: dividing
    *   Context snippet: "...a medicine that kills cells that are <t>dividing</t>, such as cancer cells..."

2.  **Analyze the meaning in context:**
    *   The sentence describes a cytotoxic medicine (pemetrexed) that kills cells.
    *   Which cells? Cells that are "dividing".
    *   In biology, "dividing" cells refer to the process of cell division (mitosis/meiosis).
    *   This process involves a single cell separating into two or more daughter cells.
    *   It is an active process of separating into parts (distinct new cells).

3.  **Evaluate candidate senses:**

    *   **Sense 1:** `divide%2:41:00::` | definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire...
        *   *Analysis:* This is the general sense of separating something into parts. In cell biology, cell division is exactly this: one cell separates into two parts (daughter cells). While the examples are physical objects (cake) or geopolitical entities, the core meaning "separate into parts" fits the biological process of cell division perfectly. A cell divides itself into two cells.

    *   **Sense 2:** `divide%2:31:00::` | definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven?
        *   *Analysis:* This is the mathematical sense. "Dividing cells" is not a math operation.

    *   **Sense 3:** `divide%2:42:00::` | definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries
        *   *Analysis:* This implies something static separating two other things. The cells are not acting as a barrier between other things; they are undergoing a process of splitting themselves.

    *   **Sense 4:** `divide%2:35:00::` | definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated
        *   *Analysis:* This is intransitive and implies breaking apart or coming loose. While cell division is intransitive (the cell divides), it is an active biological generation of new parts, not just "coming apart" like a broken toy. However, sense 1 is often used intransitively in this context ("The cell divides"). Let's look at the definition of Sense 1 again. Sense 1 is usually transitive ("divide the cake"), but can be used intransitively ("The road divides"). Sense 4's example ("The two pieces... separated") implies separation of things that were joined, often by accident or loss of cohesion. Cell division is a programmed biological process of creating parts. Sense 1 ("separate into parts") captures the generative aspect better than Sense 4 ("come apart"). Also, WordNet hierarchy usually treats "cell division" under the general concept of dividing into parts.

    *   **Sense 5:** `divide%2:38:00::` | definition=make a division or separation | synonyms=separate
        *   *Analysis:* This is very general. "Make a division". It lacks examples, making it harder to pin down specific usage compared to Sense 1. Usually, generic senses without examples are less preferred if a more specific sense with examples fits.

    *   **Sense 6:** `divide%2:35:01::` | definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea
        *   *Analysis:* This implies an external agent forcing things apart. The cells are dividing on their own (biological process), not being pulled apart by an external agent in this context (though cytotoxic medicines kill them, the *dividing* refers to the state of the cell undergoing division).

4.  **Select the best sense:**
    *   The phrase "cells that are dividing" refers to the biological process of cell division.
    *   This involves a cell separating into constituent parts (daughter cells).
    *   Sense 1 "separate into parts or portions" is the standard definition for this biological process (mitosis). When we say "The cell divides," we mean it separates into parts. The example "divide the cake" is about creating portions. A cell dividing creates portions (daughter cells).
    *   Sense 4 ("come apart") is possible as an intransitive sense, but usually implies failure of structural integrity (coming unstuck), whereas Sense 1 implies the active process of branching or splitting into new entities. Standard WordSense Disambiguation tools (like IMS, UKB) and semantic ontologies map "cell division" to the concept of separating into parts.
    *   Sense 1 is the core, general sense of the verb "to divide" (splitting something into parts). "Cells dividing" means the cells are splitting themselves into parts (daughter cells).

    Let's double-check Sense 1 vs Sense 4.
    Sense 1 definition: "separate into parts or portions".
    Sense 4 definition: "come apart".
    Context: "cells that are dividing".
    The biological term is "cell division". A cell divides into two. This fits "separate into parts".
    If I look at WordNet (3.0 or 3.1), Sense 1 (split, split up, separate, dissever, carve up) is the primary transitive/intransitive sense of splitting something into parts.
    Sense 4 (separate, part) examples: "The two pieces that we had glued separated". This suggests disintegration or separation of previously attached items.
    Cell division is a specific type of separation where one becomes two. It aligns best with the "separate into parts" definition of Sense 1. Even though Sense 1's examples are transitive, the definition applies to the process. The process is called "division". Sense 1 is the root sense for "division".
    Therefore, Sense 1 is the correct choice.

    Index check:
    1. sense_key=divide%2:41:00:: (Index 1)
    2. sense_key=divide%2:31:00:: (Index 2)
    3. sense_key=divide%2:42:00:: (Index 3)
    4. sense_key=divide%2:35:00:: (Index 4)
    5. sense_key=divide%2:38:00:: (Index 5)
    6. sense_key=divide%2:35:01:: (Index 6)

    Result: Sense 1.

provider: Friendli


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: body
Target surface form: body
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=body%1:08:00:: | definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
2. sense_key=body%1:14:00:: | definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium; the student body
3. sense_key=body%1:08:02:: | definition=a natural object consisting of a dead animal or person | synonyms=dead body | examples=they found the body in the lake
4. sense_key=body%1:17:00:: | definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. sense_key=body%1:08:01:: | definition=the body excluding the head and neck and limbs | synonyms=torso, trunk | examples=they moved their arms and legs and bodies
6. sense_key=body%1:14:02:: | definition=a collection of particulars considered as a system | examples=a body of law; a body of doctrine
7. sense_key=body%1:07:00:: | definition=the property of holding together and retaining its shape | synonyms=consistency, consistence, eubstance | examples=wool has more body than rayon; when the dough has enough consistency it is ready to bake
8. sense_key=body%1:10:00:: | definition=the central message of a communication | examples=the body of the message was short
9. sense_key=body%1:07:01:: | definition=the main mass of a thing
10. sense_key=body%1:06:01:: | definition=a resonating chamber in a musical instrument (as the body of a violin) | synonyms=soundbox
11. sense_key=body%1:06:00:: | definition=the external structure of a vehicle | examples=the body of the car was badly rusted

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the target lemma and form**: The target word is "body" (noun). The surface form is "body".

2.  **Analyze the context**: The sentence is "In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes..."
    *   The context is a medical/pharmacological text describing how a drug (Alimta/pemetrexed) works inside a living organism.
    *   It describes biochemical processes (conversion, blocking enzymes) happening within the organism.
    *   The "body" here refers to the entire physical structure of the patient (likely a human or animal) where the drug acts.

3.  **Evaluate candidate senses**:
    *   *Sense 1 (body%1:08:00::)*: "the entire structure of an organism (an animal, plant, or human being)".
        *   Synonyms: organic structure, physical structure.
        *   Example: "he felt as if his whole body were on fire".
        *   Fit: This fits perfectly. The drug acts inside the living organism's physical structure.
    *   *Sense 2 (body%1:14:00::)*: "a group of persons associated by some common tie...".
        *   Fit: Incorrect. Not a group of people.
    *   *Sense 3 (body%1:08:02::)*: "a natural object consisting of a dead animal or person".
        *   Fit: Incorrect. The context implies a living organism undergoing treatment.
    *   *Sense 4 (body%1:17:00::)*: "an individual 3-dimensional object that has mass...".
        *   Fit: Too generic/physical. Usually refers to inanimate objects or heavenly bodies.
    *   *Sense 5 (body%1:08:01::)*: "the body excluding the head and neck and limbs" (torso/trunk).
        *   Fit: Incorrect. The drug acts systemically, not just in the torso.
    *   *Sense 6 (body%1:14:02::)*: "a collection of particulars considered as a system" (body of law).
        *   Fit: Incorrect. Not an abstract collection.
    *   *Sense 7 (body%1:07:00::)*: "the property of holding together..." (consistency).
        *   Fit: Incorrect.
    *   *Sense 8 (body%1:10:00::)*: "the central message of a communication".
        *   Fit: Incorrect.
    *   *Sense 9 (body%1:07:01::)*: "the main mass of a thing".
        *   Fit: Too generic. Doesn't capture the biological organism aspect.
    *   *Sense 10 (body%1:06:01::)*: "a resonating chamber...".
        *   Fit: Incorrect.
    *   *Sense 11 (body%1:06:00::)*: "the external structure of a vehicle".
        *   Fit: Incorrect.

4.  **Confirm the best sense**: Sense 1 is the definition of a living organism's physical structure. The text describes how a drug works "in the body", meaning inside the living organism.

5.  **Format the output**: The instructions require a JSON object with the sense index. The index for the chosen sense is 1.

    {"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: convert
Target surface form: converted
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=convert%2:30:00:: | definition=change from one system to another or to a new plan or policy | synonyms=change over | examples=We converted from 220 to 110 Volt
2. sense_key=convert%2:30:03:: | definition=change the nature, purpose, or function of something | examples=convert lead into gold; convert hotels into jails
3. sense_key=convert%2:30:01:: | definition=change religious beliefs, or adopt a religious belief | examples=She converted to Buddhism
4. sense_key=convert%2:30:02:: | definition=exchange or replace with another, usually of the same kind or category | synonyms=change, exchange, commute | examples=Could you convert my dollars into pounds?; He changed his name
5. sense_key=convert%2:30:07:: | definition=cause to adopt a new or different faith | examples=The missionaries converted the Indian population
6. sense_key=convert%2:33:02:: | definition=score an extra point or points after touchdown by kicking the ball through the uprights or advancing the ball into the end zone | examples=Smith converted and his team won
7. sense_key=convert%2:33:01:: | definition=complete successfully | examples=score a penalty shot or free throw
8. sense_key=convert%2:33:00:: | definition=score (a spare)
9. sense_key=convert%2:32:00:: | definition=make (someone) agree, understand, or realize the truth or validity of something | synonyms=win over, convince | examples=He had finally convinced several customers of the advantages of his product
10. sense_key=convert%2:30:09:: | definition=exchange a penalty for a less severe one | synonyms=commute, exchange
11. sense_key=convert%2:30:04:: | definition=change in nature, purpose, or function; undergo a chemical change | examples=The substance converts to an acid

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the Context:**
    *   The sentence is: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes..."
    *   The subject is "pemetrexed" (a chemical substance/drug).
    *   The action is the transformation of pemetrexed into an "active form".
    *   This happens "in the body" via a biological/chemical process.
    *   The result is a change in the chemical structure/nature of the substance.

2.  **Analyze the Candidate Senses:**
    *   Sense 1: "change from one system to another..." (e.g., electrical voltage). Not relevant to a chemical transformation.
    *   Sense 2: "change the nature, purpose, or function of something" (e.g., lead into gold). This involves a transformation of substance. This is a strong candidate. "Convert lead into gold" parallels "convert pemetrexed into an active form".
    *   Sense 3: "change religious beliefs..." Not relevant.
    *   Sense 4: "exchange or replace with another..." (e.g., dollars into pounds). This is usually about swapping units or items of value, not a chemical reaction.
    *   Sense 5: "cause to adopt a new or different faith". Not relevant.
    *   Sense 6: Sports (American football). Not relevant.
    *   Sense 7: Sports (penalty shot). Not relevant.
    *   Sense 8: Sports (bowling). Not relevant.
    *   Sense 9: "make (someone) agree...". Not relevant.
    *   Sense 10: Legal context (commute a sentence). Not relevant.
    *   Sense 11: "change in nature, purpose, or function; undergo a chemical change" (e.g., "The substance converts to an acid").

3.  **Compare Sense 2 and Sense 11:**
    *   Sense 2 (Transitive): "change the nature... of something". Example: "convert lead into gold".
    *   Sense 11 (Intransitive/Ergative usage often implied in WordNet definitions, though the example says "The substance converts..."): "change in nature...; undergo a chemical change".
    *   Let's look at the syntactic frame in the context: "pemetrexed is converted into an active form".
    *   This is a passive construction ("is converted"). The underlying active form would be "The body converts pemetrexed into..." or "Pemetrexed converts into...".
    *   Sense 11 explicitly mentions "undergo a chemical change" and "The substance converts to an acid". The context is explicitly about a chemical/biological change.
    *   Sense 2 covers "change the nature... of something" (transitive). Example: "convert hotels into jails", "convert lead into gold".
    *   However, Sense 11 specifically includes "undergo a chemical change" in the definition, which matches the biological context of a drug metabolism perfectly.
    *   Wait, let me check the index numbering again.
        *   Sense 11 is defined as: "change in nature, purpose, or function; undergo a chemical change".
        *   Example: "The substance converts to an acid".
    *   The target word is "converted" (passive voice).
        *   "Pemetrexed is converted..." -> "Something converts pemetrexed..." (Transitive Sense 2?) OR "Pemetrexed converts..." (Intransitive Sense 11?).
    *   WordNet distinguishes these based on transitivity usually.
        *   Sense 2: "change the nature... *of something*". (Transitive). Example: "convert lead into gold". This fits the "A is converted into B" structure perfectly. Passive of transitive.
        *   Sense 11: "change in nature...; undergo a chemical change". (Intransitive). Example: "The substance converts to an acid".
    *   If the sentence was "Pemetrexed converts into an active form", Sense 11 would be perfect.
    *   The sentence is "Pemetrexed is converted into an active form". This is passive. Passive voice usually corresponds to a transitive sense.
    *   Let's look at Sense 2 again. "change the nature, purpose, or function of something". Examples: "convert lead into gold", "convert hotels into jails". This is the transitive sense of transformation.
    *   Let's look at Sense 11 again. It says "undergo a chemical change". While the *process* is chemical, the syntactic frame "is converted" implies an agent or a general process acting on the object, which aligns better with the transitive Sense 2 definition "change the nature... of something".
    *   However, WordNet often tags chemical conversions under specific scientific definitions if available. Sense 11 explicitly has "chemical change" in the gloss.
    *   Let's look at the mapping often used in WSD tasks (like OntoNotes or SemCor).
    *   Sense 2 is general transformation.
    *   Sense 11 is specific to chemical change/intransitive use often, or the chemical sense specifically.
    *   Let's consider the overlap. If I "convert X into Y", I am using Sense 2. If X "converts into Y", I am using Sense 11.
    *   The text is "pemetrexed is converted".
    *   "is converted" is the passive of "converts (something)".
    *   Therefore, Sense 2 (Transitive) is the syntactic match.
    *   Does Sense 11 cover the transitive use? The definition says "change in nature...". It doesn't say "change *something*". It says "The substance converts...". This suggests intransitive.
    *   Therefore, strictly speaking, Sense 2 is the transitive sense required by the passive construction.
    *   Does Sense 2 cover chemical transformation? Yes, "convert lead into gold" is a chemical/physical transformation.
    *   Is there a more specific sense?
    *   Let's check if Sense 11 can be transitive. Usually, ergative verbs in WordNet are split.
    *   If I choose Sense 11, I am saying the word is being used intransitively. But the passive auxiliary "is" indicates it's a transitive usage.
    *   *Correction*: Sometimes WordNet senses are not strictly split by transitivity in the way a linguist might hope, but usually, they are.
    *   Let's look at the provided sense list again.
    *   Sense 2: "change the nature, purpose, or function of something" -> Transitive.
    *   Sense 11: "change in nature...; undergo a chemical change" -> Intransitive.
    *   The context sentence: "pemetrexed is converted..." -> Passive -> Transitive -> Sense 2.

    *   Wait, let me reconsider Sense 11. Sometimes specific domains (Chemistry) override syntax.
    *   However, the example for Sense 11 is strictly intransitive ("The substance converts").
    *   The examples for Sense 2 are transitive ("convert lead into gold").
    *   Since the sentence is "is converted" (passive of transitive), Sense 2 is the correct syntactic frame.
    *   The content (chemical change) fits Sense 2's example "lead into gold" (transmutation).

    *   Let's check if there's ambiguity with Sense 4. "Exchange or replace... convert dollars into pounds". This is substitution, not transformation. The drug molecule changes its structure to become active, it is not swapped for another molecule. So Sense 4 is out.

    *   So it's between Sense 2 and Sense 11.
    *   Sense 2: Transitive transformation.
    *   Sense 11: Intransitive chemical conversion.
    *   The sentence uses the passive form of a transitive verb. "Pemetrexed is converted".
    *   Therefore, the active form is "The body/enzymes convert pemetrexed".
    *   This matches Sense 2: "change the nature... of something". "Something" = pemetrexed.
    *   Therefore, Sense 2 is the best fit.

    *   Let me double check if Sense 11 is sometimes used for the transitive in automated systems or specific annotation guidelines. In WordNet 3.0/3.1:
        *   convert%2:30:04:: (Sense 11 in this list) is the intransitive chemical sense.
        *   convert%2:30:03:: (Sense 2 in this list) is the transitive transformation sense.
    *   Context: "In the body, pemetrexed is converted into an active form..."
    *   This describes a chemical reaction (metabolism).
    *   However, without a specific "transitive chemical" sense listed, the general transitive transformation sense (Sense 2) covers the syntactic structure and the semantic content (changing nature/substance).
    *   Sense 2 example "convert lead into gold" is a chemical transformation (albeit a fictional one).
    *   Therefore, Sense 2 covers the chemical transformation aspect when used transitively.

    *   Decision: Sense 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
7. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
13. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
1.  **Analyze the context:**
    The sentence is: "In the body, pemetrexed is converted into an *active* form that blocks the activity of the enzymes..."
    The subject is pemetrexed, a chemical substance (medicine).
    The phrase is "active form".
    The meaning implies that the converted form has a specific effect (blocking enzymes). It is chemically or biologically potent/effective.

2.  **Analyze the candidate senses:**
    *   Sense 1: "tending to become more severe or wider in scope" (e.g., active tuberculosis). Incorrect. This refers to disease progression.
    *   Sense 2: "engaged in or ready for military or naval operations". Incorrect. Military context.
    *   Sense 3: "disposed to take action or effectuate change" (e.g., active interest). Incorrect. This usually applies to people or agents with volition.
    *   Sense 4: "taking part in an activity" (e.g., active member). Incorrect. Sociological context.
    *   Sense 5: "characterized by energetic activity" (e.g., active toddler). Incorrect. Physical movement.
    *   Sense 6: "exerting influence or producing a change or effect" (e.g., an active ingredient). This fits perfectly. Pemetrexed is converted into a form that exerts influence (blocks enzymes). This is the standard pharmacological definition of "active" regarding ingredients or forms of drugs.
    *   Sense 7: "full of activity or engaged in continuous activity" (e.g., active seaport). Incorrect.
    *   Sense 8: "in operation" (e.g., keep hope alive). Incorrect. Functional/existential status, not chemical potency.
    *   Sense 9: "(of the sun)...". Incorrect.
    *   Sense 10: "expressing that the subject of the sentence has the semantic function of actor". Incorrect. Grammatical context.
    *   Sense 11: "(used of verbs...)". Incorrect. Grammatical context.
    *   Sense 12: "(of e.g. volcanos) capable of erupting". Incorrect.
    *   Sense 13: "(of e.g. volcanos) erupting...". Incorrect.
    *   Sense 14: "engaged in full-time work". Incorrect.

3.  **Select the best sense:**
    Sense 6 ("exerting influence or producing a change or effect") is the definition used for active substances, active ingredients, or active forms of drugs. The example "an active ingredient" aligns exactly with the context of a pharmaceutical description ("active substance", "active form").

4.  **Format output:**
    The user wants a JSON object with "sense_index". The index corresponds to the list numbering provided in the prompt (1 through 14).
    Sense 6 is the correct one.

    Double check indices.
    1. sense_key=active%3:00:02::
    2. sense_key=active%5:00:00:operational:00
    3. sense_key=active%3:00:03::
    4. sense_key=active%5:00:00:involved:00
    5. sense_key=active%3:00:01::
    6. sense_key=active%3:00:07:: -> "exerting influence or producing a change or effect".

    Yes, it is index 6.