[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: other
Target surface form: other
Context:
Researchers in Edinburgh, Scotland, have found that in 23 of 38 breast tumors, one copy of chromosome 17 was mutated at the spot where gene p53 lies. The scientists say that since breast cancer often strikes multiple members of certain families, the gene, when inherited in a damaged form, may predispose women to the cancer. The p53 gene has just been implicated in lung cancer. In a report out last week, John Minna and colleagues at the National Cancer Institute say that about half the cells taken from lung cancer tissue they tested are missing this gene. There also are reports from several labs, as yet unpublished, of missing p53 genes in tissue taken from kidney, brain and skin cancers. At the same time, the Johns Hopkins team and others are rushing to pinpoint <t>other</t> tumor-suppressor genes. Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer.

Candidate senses:
1. sense_key=other%3:00:00:: | definition=not the same one or ones already mentioned or implied; - the White Queen | examples=today isn't any other day; the construction of highways and other public works
2. sense_key=other%5:00:00:past:00 | definition=recently past | examples=the other evening
3. sense_key=other%5:00:02:past:00 | definition=belonging to the distant past | synonyms=early, former | examples=the early inhabitants of Europe; former generations
4. sense_key=other%5:00:00:strange:00 | definition=very unusual; different in character or quality from the normal or expected; - Lance Morrow | examples=a strange, other dimension...where his powers seemed to fail

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: hope
Target surface form: hopes
Context:
The scientists say that since breast cancer often strikes multiple members of certain families, the gene, when inherited in a damaged form, may predispose women to the cancer. The p53 gene has just been implicated in lung cancer. In a report out last week, John Minna and colleagues at the National Cancer Institute say that about half the cells taken from lung cancer tissue they tested are missing this gene. There also are reports from several labs, as yet unpublished, of missing p53 genes in tissue taken from kidney, brain and skin cancers. At the same time, the Johns Hopkins team and others are rushing to pinpoint other tumor-suppressor genes. Dr. Vogelstein <t>hopes</t> soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5.

Candidate senses:
1. sense_key=hope%2:37:01:: | definition=expect and wish | synonyms=trust, desire | examples=I trust you will behave better from now on; I hope she understands that she cannot expect a raise
2. sense_key=hope%2:37:00:: | definition=be optimistic; be full of hope; have hopes | examples=I am still hoping that all will turn out well
3. sense_key=hope%2:31:00:: | definition=intend with some possibility of fulfilment | synonyms=go for | examples=I hope to have finished this work by tomorrow evening

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

finish_reason: stop

role: assistant

reasoning_content:
Here's my analysis of the statement "Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer," breaking down my thought process:

**Deconstructing the Verb "Hopes"**

Okay, so the target word is "hopes." My mind immediately jumps to the common grammatical structure: "hopes to [infinitive]." I recognize that this signifies an intention, but not a guarantee of success. It's an aspiration, a planned action with the underlying understanding that it might not come to pass, but the speaker certainly intends to bring it about.

This resonates with the third sense I hold for the word "hope": "intend with some possibility of fulfilment." The examples that pop into my head are similar – “I hope to have finished this work by tomorrow evening," or "I hope to solve this complex problem". It's a statement of future action with some element of uncertainty. It is not like a guarantee or a prediction. It is a plan.

type: thinking

service_tier: default

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: involved
Target surface form: involved
Context:
The scientists say that since breast cancer often strikes multiple members of certain families, the gene, when inherited in a damaged form, may predispose women to the cancer. The p53 gene has just been implicated in lung cancer. In a report out last week, John Minna and colleagues at the National Cancer Institute say that about half the cells taken from lung cancer tissue they tested are missing this gene. There also are reports from several labs, as yet unpublished, of missing p53 genes in tissue taken from kidney, brain and skin cancers. At the same time, the Johns Hopkins team and others are rushing to pinpoint other tumor-suppressor genes. Dr. Vogelstein hopes soon to isolate one on chromosome 18, also <t>involved</t> in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5.

Candidate senses:
1. sense_key=involved%3:00:00:: | definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved; the problems involved
2. sense_key=involved%5:00:00:encumbered:00 | definition=entangled or hindered as if e.g. in mire | synonyms=mired | examples=the difficulties in which the question is involved; brilliant leadership mired in details and confusion
3. sense_key=involved%5:00:00:attached:01 | definition=emotionally involved
4. sense_key=involved%5:00:00:complex:00 | definition=highly complex or intricate and occasionally devious; ; ; ; ; ; ; ; - Sir Walter Scott | synonyms=Byzantine, convoluted, knotty, tangled, tortuous | examples=the Byzantine tax structure; Byzantine methods for holding on to his chairmanship
5. sense_key=involved%5:00:00:enclosed:00 | definition=enveloped | examples=a castle involved in mist; the difficulties in which the question is involved

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Nuances of "Involved"**

Okay, so the target word is "involved," and the context is Dr. Vogelstein's work with chromosome 18 and colon cancer. My mind immediately begins to dissect the possible senses. Let's see... I've got a few candidates. There's the obvious one: sense 1, "connected by participation or association or use," which seems like the front-runner. That's the most straightforward interpretation given the subject matter. It suggests that chromosome 18 has a direct *connection* to colon cancer.

Then there are the other, more figurative options, like "entangled" (sense 2), "emotionally involved" (sense 3), "highly complex" (sense 4), and "enveloped" (sense 5). While all of these have potential applications in broader contexts, they just don't seem to fit here. "Entangled" suggests a negative impediment, and there isn't anything to suggest a negative association. "Emotionally involved" is completely irrelevant to genetic research. "Highly complex" is a possible description, but not the same as the "involved" Dr. Vogelstein is hoping to show. And "enveloped" is a similarly vague and unlikely descriptor.

Therefore, the first sense – the one emphasizing *association and participation* – is the only logical fit. It's the most precise and scientifically sound interpretation. The other senses are simply too far afield to be considered seriously in this particular context. It's really quite straightforward, actually.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: close
Target surface form: close
Context:
The p53 gene has just been implicated in lung cancer. In a report out last week, John Minna and colleagues at the National Cancer Institute say that about half the cells taken from lung cancer tissue they tested are missing this gene. There also are reports from several labs, as yet unpublished, of missing p53 genes in tissue taken from kidney, brain and skin cancers. At the same time, the Johns Hopkins team and others are rushing to pinpoint other tumor-suppressor genes. Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are <t>close</t> to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer.

Candidate senses:
1. sense_key=close%3:00:01:: | definition=at or within a short distance in space or time or having elements near each other | examples=close to noon; how close are we to town?
2. sense_key=close%3:00:02:: | definition=close in relevance or relationship | examples=a close family; we are all...in close sympathy with...
3. sense_key=close%3:00:05:: | definition=not far distant in time or space or degree or circumstances | synonyms=near, nigh | examples=near neighbors; in the near future
4. sense_key=close%5:00:00:careful:00 | definition=rigorously attentive; strict and thorough | examples=close supervision; paid close attention
5. sense_key=close%5:00:00:accurate:00 | definition=marked by fidelity to an original | synonyms=faithful | examples=a close translation; a faithful copy of the portrait
6. sense_key=close%5:00:00:equal:00 | definition=(of a contest or contestants) evenly matched | synonyms=tight | examples=a close contest; a close election
7. sense_key=close%5:00:00:confined:00 | definition=crowded | synonyms=confining | examples=close quarters
8. sense_key=close%5:00:00:unventilated:00 | definition=lacking fresh air | synonyms=airless, stuffy, unaired | examples=a dusty airless attic; the dreadfully close atmosphere
9. sense_key=close%5:00:00:fine:00 | definition=of textiles | synonyms=tight | examples=a close weave; smooth percale with a very tight weave
10. sense_key=close%5:00:00:restrained:00 | definition=strictly confined or guarded | examples=kept under close custody
11. sense_key=close%5:00:00:private:00 | definition=confined to specific persons | examples=a close secret
12. sense_key=close%5:00:00:tight:01 | definition=fitting closely but comfortably | synonyms=snug, close-fitting | examples=a close fit
13. sense_key=close%5:00:00:short:01 | definition=used of hair or haircuts | examples=a close military haircut
14. sense_key=close%5:00:00:stingy:00 | definition=giving or spending with reluctance | synonyms=cheeseparing, near, penny-pinching, skinny | examples=our cheeseparing administration; very close (or near) with his money
15. sense_key=close%5:00:00:uncommunicative:00 | definition=inclined to secrecy or reticence about divulging information | synonyms=closelipped, closemouthed, secretive, tightlipped | examples=although they knew her whereabouts her friends kept close about it

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 3}
```

content:
```json
{"sense_index": 3}
```

reasoning_content:
**Analyzing the Nuances of "Close"**

Okay, so the phrase is "close to finding." My immediate thought is, this signifies proximity to a goal – progress, really. Let's delve into the senses of "close," which of course, I am well familiar with.

First, I think of the most common sense: physical or temporal proximity – *close to noon, how close are we to town?* But then, there's another related sense: not far in time, space, degree, or circumstance. Almost interchangeable with "near."

WordNet is invaluable here. It distinguishes between *close%3:00:01::* and *close%3:00:05::*, it's helpful to see these explicitly called out. *Close%3:00:01::* is the spatial/temporal "short distance" sense. *Close%3:00:05::* is *near, nigh* – it's all about nearness in *time, space, degree, or circumstances*. And the synonyms are important: near, close, nigh...

Now, I need to pinpoint the relevant sense for "close to finding." Is it space, time, or degree/circumstance? "Close to finding" is clearly a measure of *progress* in time, and *circumstance*, or degree, so it is the third sense. WordNet usually links "close to [verb]ing" or "near to [verb]ing" to that third sense: not far distant in *time, space, or circumstance*. This confirms that my initial intuition was correct: we're discussing proximity to achievement.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: find
Target surface form: finding
Context:
The p53 gene has just been implicated in lung cancer. In a report out last week, John Minna and colleagues at the National Cancer Institute say that about half the cells taken from lung cancer tissue they tested are missing this gene. There also are reports from several labs, as yet unpublished, of missing p53 genes in tissue taken from kidney, brain and skin cancers. At the same time, the Johns Hopkins team and others are rushing to pinpoint other tumor-suppressor genes. Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to <t>finding</t> another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer.

Candidate senses:
1. sense_key=find%2:40:02:: | definition=come upon, as if by accident; meet with | synonyms=happen, chance, bump, encounter | examples=We find this idea in Plato; I happened upon the most wonderful bakery not very far from here
2. sense_key=find%2:39:02:: | definition=discover or determine the existence, presence, or fact of | synonyms=detect, observe, discover, notice | examples=She detected high levels of lead in her drinking water; We found traces of lead in the paint
3. sense_key=find%2:40:00:: | definition=come upon after searching; find the location of something that was missed or lost | synonyms=regain | examples=Did you find your glasses?; I cannot find my gloves!
4. sense_key=find%2:32:00:: | definition=establish after a calculation, investigation, experiment, survey, or study | synonyms=determine, find out, ascertain | examples=find the product of two numbers; The physicist who found the elusive particle won the Nobel Prize
5. sense_key=find%2:31:10:: | definition=come to believe on the basis of emotion, intuitions, or indefinite grounds | synonyms=feel | examples=I feel that he doesn't like me; I find him to be obnoxious
6. sense_key=find%2:39:01:: | definition=perceive or be contemporaneous with | synonyms=witness, see | examples=We found Republicans winning the offices; You'll see a lot of cheating in this school
7. sense_key=find%2:40:01:: | definition=get something or somebody for a specific purpose | synonyms=line up, get hold, come up | examples=I found this gadget that will serve as a bottle opener; I got hold of these tools to fix our plumbing
8. sense_key=find%2:36:00:: | definition=make a discovery, make a new finding | synonyms=discover | examples=Roentgen discovered X-rays; Physicists believe they found a new elementary particle
9. sense_key=find%2:31:09:: | definition=make a discovery | synonyms=discover | examples=She found that he had lied to her; The story is false, so far as I can discover
10. sense_key=find%2:40:03:: | definition=obtain through effort or management | examples=She found the time and energy to take care of her aging parents; We found the money to send our sons to college
11. sense_key=find%2:32:01:: | definition=decide on and make a declaration about | synonyms=rule | examples=find someone guilty
12. sense_key=find%2:30:00:: | definition=receive a specified treatment (abstract) | synonyms=receive, get, obtain, incur | examples=These aspects of civilization do not find expression or receive an interpretation; His movie received a good review
13. sense_key=find%2:39:05:: | definition=perceive oneself to be in a certain condition or place | examples=I found myself in a difficult situation; When he woke up, he found himself in a hospital room
14. sense_key=find%2:40:15:: | definition=get or find back; recover the use of | synonyms=recover, retrieve, regain | examples=She regained control of herself; She found her voice and replied quickly
15. sense_key=find%2:38:10:: | definition=succeed in reaching; arrive at | examples=The arrow found its mark
16. sense_key=find%2:30:13:: | definition=accept and make use of one's personality, abilities, and situation | synonyms=find oneself | examples=My son went to Berkeley to find himself

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
**Analyzing the Nuances of "Find" in Scientific Contexts**

Okay, so I'm processing this sentence: "Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5." My initial thought is to pinpoint the exact meaning of "finding" here. It's crucial for understanding the state of their research.

I'm immediately drawn to the subtle difference between two senses of "find." Sense 8, which is listed as "make a discovery, make a new finding" (synonym: discover), immediately feels relevant. The examples "Roentgen discovered X-rays" and "Physicists believe they found a new elementary particle" solidify this connection. That aligns with the idea of uncovering something novel – another gene.

Then I check Sense 4, which is listed as "establish after a calculation, investigation, experiment, survey, or study" (synonyms: determine, find out, ascertain). The examples "find the product of two numbers" or "The physicist who found the elusive particle won the Nobel Prize" feel like a better fit. But wait, that second example, "The physicist who found the elusive particle won the Nobel Prize," is also under sense 8! That's interesting, but I feel like both senses are close.

The definition of sense 4 emphasizes a process of establishing something through calculation, investigation, or experimentation. Sense 8, however, is about the act of *making* a discovery.

Since they're looking for *another* gene, a novel entity, I think Sense 8, "make a discovery, make a new finding," is the more appropriate meaning here. It implies they are on the verge of uncovering something new about the genetic basis of colon cancer.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: involved
Target surface form: involved
Context:
The p53 gene has just been implicated in lung cancer. In a report out last week, John Minna and colleagues at the National Cancer Institute say that about half the cells taken from lung cancer tissue they tested are missing this gene. There also are reports from several labs, as yet unpublished, of missing p53 genes in tissue taken from kidney, brain and skin cancers. At the same time, the Johns Hopkins team and others are rushing to pinpoint other tumor-suppressor genes. Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene <t>involved</t> with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer.

Candidate senses:
1. sense_key=involved%3:00:00:: | definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved; the problems involved
2. sense_key=involved%5:00:00:encumbered:00 | definition=entangled or hindered as if e.g. in mire | synonyms=mired | examples=the difficulties in which the question is involved; brilliant leadership mired in details and confusion
3. sense_key=involved%5:00:00:attached:01 | definition=emotionally involved
4. sense_key=involved%5:00:00:complex:00 | definition=highly complex or intricate and occasionally devious; ; ; ; ; ; ; ; - Sir Walter Scott | synonyms=Byzantine, convoluted, knotty, tangled, tortuous | examples=the Byzantine tax structure; Byzantine methods for holding on to his chairmanship
5. sense_key=involved%5:00:00:enclosed:00 | definition=enveloped | examples=a castle involved in mist; the difficulties in which the question is involved

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
Here's my analysis of the query, presented as if it were my thought process:

**Deconstructing the Semantic Landscape of "Involved"**

Alright, let's break this down. The core of the prompt is the word "involved," specifically within the context of "finding another gene involved with some types of colon cancer." Immediately, I'm keying in on the polysemy of "involved." I need to determine the intended sense.

Given the phrase, the most logical and relevant sense here is, undoubtedly, sense 1: "connected by participation or association or use". It's the only one that makes sense biologically. We are talking about gene *association*. It's not involved in anything else other than connection.

So, the focus is on the *relationship* between a gene and colon cancer. My task is to understand, and then explain, how that word is being used in this specific biomedical context. That sense is the crucial element I must keep at the forefront.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: type
Target surface form: types
Context:
The p53 gene has just been implicated in lung cancer. In a report out last week, John Minna and colleagues at the National Cancer Institute say that about half the cells taken from lung cancer tissue they tested are missing this gene. There also are reports from several labs, as yet unpublished, of missing p53 genes in tissue taken from kidney, brain and skin cancers. At the same time, the Johns Hopkins team and others are rushing to pinpoint other tumor-suppressor genes. Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some <t>types</t> of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer.

Candidate senses:
1. sense_key=type%1:09:00:: | definition=a subdivision of a particular kind of thing | examples=what type of sculpture do you prefer?
2. sense_key=type%1:18:00:: | definition=a person of a specified kind (usually with many eccentricities) | synonyms=character, eccentric, case | examples=a real character; a strange character
3. sense_key=type%1:14:01:: | definition=(biology) the taxonomic group whose characteristics are used to define the next higher taxon
4. sense_key=type%1:10:01:: | definition=printed characters | examples=small type is hard to read
5. sense_key=type%1:10:00:: | definition=all of the tokens of the same symbol | examples=the word `element' contains five different types of character
6. sense_key=type%1:06:00:: | definition=a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper | examples=he dropped a case of type, so they made him pick them up

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
Here's my summary, as though I'm thinking through this:

**Analyzing the Word "Types" in Context**

Okay, so the target is "types" in the phrase "some types of colon cancer." Right off the bat, I'm thinking we need to establish the primary sense being used here. Given the context, the most likely sense, and the one that intuitively makes the most sense, is the idea of a **subdivision within a broader category**. It's not about typing on a keyboard, or anything unrelated to categorization. "Types" here means "varieties" or "subclasses" – distinct groups that fall under the umbrella of colon cancer. This suggests we are discussing different *kinds* of the disease, perhaps differentiated by genetic markers, histological features, or treatment responses. Let's keep that in mind as we delve deeper.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: believe
Target surface form: believes
Context:
In a report out last week, John Minna and colleagues at the National Cancer Institute say that about half the cells taken from lung cancer tissue they tested are missing this gene. There also are reports from several labs, as yet unpublished, of missing p53 genes in tissue taken from kidney, brain and skin cancers. At the same time, the Johns Hopkins team and others are rushing to pinpoint other tumor-suppressor genes. Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna <t>believes</t> people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer. Recently, he and others reported that the retinoblastoma suppressor gene may also be involved in some lung cancers, as well as several other more common cancers, too.

Candidate senses:
1. sense_key=believe%2:31:00:: | definition=accept as true; take to be true | examples=I believed his report; We didn't believe his stories from the War
2. sense_key=believe%2:31:04:: | definition=judge or regard; look upon; judge | synonyms=think, consider, conceive | examples=I think he is very smart; I believe her to be very smart
3. sense_key=believe%2:31:03:: | definition=be confident about something | synonyms=trust | examples=I believe that he will come back from the war
4. sense_key=believe%2:31:01:: | definition=follow a credo; have a faith; be a believer | examples=When you hear his sermons, you will be able to believe, too
5. sense_key=believe%2:31:02:: | definition=credit with veracity | examples=You cannot believe this man; Should we believe a publication like the National Enquirer?

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

content:
```json
{"sense_index": 2}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: people
Target surface form: people
Context:
In a report out last week, John Minna and colleagues at the National Cancer Institute say that about half the cells taken from lung cancer tissue they tested are missing this gene. There also are reports from several labs, as yet unpublished, of missing p53 genes in tissue taken from kidney, brain and skin cancers. At the same time, the Johns Hopkins team and others are rushing to pinpoint other tumor-suppressor genes. Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes <t>people</t> who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer. Recently, he and others reported that the retinoblastoma suppressor gene may also be involved in some lung cancers, as well as several other more common cancers, too.

Candidate senses:
1. sense_key=people%1:14:00:: | definition=(plural) any group of human beings (men or women or children) collectively | examples=old people; there were at least 200 people in the audience
2. sense_key=people%1:14:01:: | definition=the body of citizens of a state or country | synonyms=citizenry | examples=the Spanish people
3. sense_key=people%1:14:02:: | definition=members of a family line | examples=his people have been farmers for generations; are your people still alive?
4. sense_key=people%1:14:03:: | definition=the common people generally | synonyms=multitude, masses, mass, hoi polloi, the great unwashed | examples=separate the warriors from the mass; power to the people

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
Okay, let's break this down.

**"People" - Navigating Word Sense Disambiguation**

Alright, so the target word is "people," as in, "...believes people who inherit a defective gene...". It seems pretty straightforward, but I need to quickly run through the senses to be certain I'm using the correct one. Let's see:

*   Sense 1: "Any group of human beings collectively." Yep, that's the default, the most general meaning. Sounds immediately promising.
*   Sense 2: "The body of citizens of a state or country." That's less likely in this context, unless we're talking about a specific population's attitudes towards genetics, but it's not the primary inference.
*   Sense 3: "Members of a family line." Hmm, this could *potentially* be relevant if we were talking about familial tendencies towards diseases. Still, not the main focus here, and would need more contextual clues.
*   Sense 4: "The common people generally." Again, potentially relevant if we were discussing societal attitudes toward inherited diseases, but not the most immediately apparent meaning.

Given the context, sense 1, "any group of human beings collectively," is the clear winner. I'm going with the broadest, most general understanding of the word "people." No need to overthink it; the meaning is evident.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: inherit
Target surface form: inherit
Context:
In a report out last week, John Minna and colleagues at the National Cancer Institute say that about half the cells taken from lung cancer tissue they tested are missing this gene. There also are reports from several labs, as yet unpublished, of missing p53 genes in tissue taken from kidney, brain and skin cancers. At the same time, the Johns Hopkins team and others are rushing to pinpoint other tumor-suppressor genes. Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who <t>inherit</t> a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer. Recently, he and others reported that the retinoblastoma suppressor gene may also be involved in some lung cancers, as well as several other more common cancers, too.

Candidate senses:
1. sense_key=inherit%2:40:00:: | definition=obtain from someone after their death | examples=I inherited a castle from my French grandparents
2. sense_key=inherit%2:40:02:: | definition=receive from a predecessor | examples=The new chairman inherited many problems from the previous chair
3. sense_key=inherit%2:40:01:: | definition=receive by genetic transmission | examples=I inherited my good eyesight from my mother

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 3}
```

reasoning_content:
Okay, here's my take on those thoughts, framed as my own understanding, given my expertise:

**My Analysis of "Inherit" in a Genetic Context**

Right, so we're talking about the word "inherit" here, and it's specifically about individuals who have a defective gene on one of their two copies of chromosome 3. The context instantly flags this as genetic transmission. We're dealing with the flow of genetic material from parents to offspring, or from prior generations to a subsequent one. Given that we are dealing with a defective gene, we can surmise that we are talking about either a genetic mutation passed on, or a gene that has predispositions to cause a particular effect.

Therefore, the most direct and accurate candidate here is, without a doubt, "receive by genetic transmission". It accurately captures the essence of inheriting a gene, defect and all, through the mechanisms of DNA replication and gamete formation. It speaks to the process by which that genetic material becomes part of an individual's genome. It's a precise and appropriate choice, reflecting the biological reality of this scenario.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: copy
Target surface form: copies
Context:
In a report out last week, John Minna and colleagues at the National Cancer Institute say that about half the cells taken from lung cancer tissue they tested are missing this gene. There also are reports from several labs, as yet unpublished, of missing p53 genes in tissue taken from kidney, brain and skin cancers. At the same time, the Johns Hopkins team and others are rushing to pinpoint other tumor-suppressor genes. Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two <t>copies</t> of chromosome 3 are especially prone to lung cancer. Recently, he and others reported that the retinoblastoma suppressor gene may also be involved in some lung cancers, as well as several other more common cancers, too.

Candidate senses:
1. sense_key=copy%1:10:00:: | definition=a reproduction of a written record (e.g. of a legal or school record) | synonyms=transcript
2. sense_key=copy%1:06:00:: | definition=a thing made to be similar or identical to another thing | examples=she made a copy of the designer dress; the clone was a copy of its ancestor
3. sense_key=copy%1:10:01:: | definition=matter to be printed; exclusive of graphical materials | synonyms=written matter
4. sense_key=copy%1:10:02:: | definition=material suitable for a journalistic account | examples=catastrophes make good copy

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
Okay, here's my interpretation of that thought process, tailored for an expert audience:

**Analyzing "Two Copies of Chromosome 3"**

Alright, let's break this down. We're looking at "two copies of chromosome 3." The term "copy" immediately triggers a cascade of potential meanings. My mind quickly filters through the common usages, the nuances of the word are important here. I'm seeing a transcript, a replicate, something identical, printable matter, and something journal-worthy. The key, of course, lies in the context.

The most precise and relevant sense is definitely **sense 2: "a thing made to be similar or identical to another thing."** It's the only meaning that truly makes sense when thinking about chromosomes. When we say "two copies," we're not talking about a transcript of the sequence, or a journalistic piece *about* it. We're referring to the physical entity – the chromosome replicate, the homolog. It represents the accurate state of the chromosome's duplication.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: especially
Target surface form: especially
Context:
In a report out last week, John Minna and colleagues at the National Cancer Institute say that about half the cells taken from lung cancer tissue they tested are missing this gene. There also are reports from several labs, as yet unpublished, of missing p53 genes in tissue taken from kidney, brain and skin cancers. At the same time, the Johns Hopkins team and others are rushing to pinpoint other tumor-suppressor genes. Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are <t>especially</t> prone to lung cancer. Recently, he and others reported that the retinoblastoma suppressor gene may also be involved in some lung cancers, as well as several other more common cancers, too.

Candidate senses:
1. sense_key=especially%4:02:00:: | definition=to a distinctly greater extent or degree than is common | synonyms=particularly, peculiarly, specially | examples=he was particularly fussy about spelling; a particularly gruesome attack
2. sense_key=especially%4:02:01:: | definition=in a special manner | synonyms=specially | examples=a specially arranged dinner

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
Okay, here's my interpretation of that thought process, tailored for an expert audience:

**Analyzing "Especially" in Context**

Alright, the key here is the word "especially," modifying "prone." My immediate task is to nail down the precise semantic contribution of "especially" in this specific phrase, "especially prone to lung cancer." I'm quickly cycling through the common senses of "especially," focusing on how they interact with "prone."

My first thought is the intensifier sense – sense 1 in the dictionary definition: "to a distinctly greater extent or degree than is common." That's the core of "particularly," "peculiarly," or "specially" in this context. It suggests an elevated degree of susceptibility. Specifically, it implies the subject has a significantly heightened probability of contracting lung cancer compared to a baseline. It's not just "prone," but *particularly* prone. The second sense, "in a special manner", is clearly not relevant here. So, the intensified degree of proneness is the appropriate definition.

The fit is quite straightforward: "especially" is acting as an intensifier, emphasizing that the entity described is *particularly* prone to the disease. The phrase is working fine.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: report
Target surface form: reported
Context:
There also are reports from several labs, as yet unpublished, of missing p53 genes in tissue taken from kidney, brain and skin cancers. At the same time, the Johns Hopkins team and others are rushing to pinpoint other tumor-suppressor genes. Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer. Recently, he and others <t>reported</t> that the retinoblastoma suppressor gene may also be involved in some lung cancers, as well as several other more common cancers, too. Where these discoveries will lead, scientists can only speculate.

Candidate senses:
1. sense_key=report%2:32:00:: | definition=to give an account or representation of in words | synonyms=describe, account | examples=Discreet Italian police described it in a manner typically continental
2. sense_key=report%2:32:04:: | definition=announce as the result of an investigation or experience or finding | examples=Dozens of incidents of wife beatings are reported daily in this city; The team reported significant advances in their research
3. sense_key=report%2:32:03:: | definition=announce one's presence | examples=I report to work every day at 9 o'clock
4. sense_key=report%2:32:01:: | definition=make known to the authorities | examples=One student reported the other to the principal
5. sense_key=report%2:32:13:: | definition=be responsible for reporting the details of, as in journalism | synonyms=cover | examples=Snow reported on China in the 1950's; The cub reporter covered New York City
6. sense_key=report%2:32:02:: | definition=complain about; make a charge against | examples=I reported her to the supervisor

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
Here's my take on the word "reported" in that context:

**Analyzing the Nuances of "Reported"**

Okay, so the task is to nail down the most appropriate sense of "reported" within the phrase "he and others reported that the retinoblastoma suppressor gene...". My immediate instinct, given the subject matter – a gene's involvement in cancer – tells me this is likely scientific communication. Now, let's break down the candidate senses. Sense 2, specifically, grabs my attention: "announce as the result of an investigation or experience or finding." Bingo! That’s it. That definition is precisely the essence of scientific reporting. It captures the idea of sharing newly acquired knowledge, findings derived from research or experimentation, and the formal announcement of those results. This is not just a casual mention; this "reporting" implies a deliberate, structured dissemination of data and conclusions, likely through a publication, presentation, or formal communication within the scientific community. It's the hallmark of disseminating research, and it fits this context perfectly.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: involved
Target surface form: involved
Context:
There also are reports from several labs, as yet unpublished, of missing p53 genes in tissue taken from kidney, brain and skin cancers. At the same time, the Johns Hopkins team and others are rushing to pinpoint other tumor-suppressor genes. Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer. Recently, he and others reported that the retinoblastoma suppressor gene may also be <t>involved</t> in some lung cancers, as well as several other more common cancers, too. Where these discoveries will lead, scientists can only speculate.

Candidate senses:
1. sense_key=involved%3:00:00:: | definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved; the problems involved
2. sense_key=involved%5:00:00:encumbered:00 | definition=entangled or hindered as if e.g. in mire | synonyms=mired | examples=the difficulties in which the question is involved; brilliant leadership mired in details and confusion
3. sense_key=involved%5:00:00:attached:01 | definition=emotionally involved
4. sense_key=involved%5:00:00:complex:00 | definition=highly complex or intricate and occasionally devious; ; ; ; ; ; ; ; - Sir Walter Scott | synonyms=Byzantine, convoluted, knotty, tangled, tortuous | examples=the Byzantine tax structure; Byzantine methods for holding on to his chairmanship
5. sense_key=involved%5:00:00:enclosed:00 | definition=enveloped | examples=a castle involved in mist; the difficulties in which the question is involved

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
Okay, here's my interpretation of that thought process, tailored for an expert audience:

**Analyzing "Involved" in the Context of Oncogenesis**

Alright, the word I'm working with is "involved," specifically in the phrase "the retinoblastoma suppressor gene may also be *involved* in some lung cancers." My focus here is nailing down the precise nuance of "involved." We're talking about a gene, the retinoblastoma suppressor, and its potential role in lung cancer. Therefore, I need to pinpoint what "involved" truly means in this oncogenic context.

Essentially, I'm parsing this for meaning to understand the relationship being described. Is it a direct causal interaction? An indirect association? Or perhaps the gene’s function is being *used* in an unanticipated pathway? The dictionary definition points towards connection via participation, association, or use. That's the starting point. I'm leaning heavily towards its involvement being a complex oncogenic role. I need to keep the specifics of the connection in mind as I approach this.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: other
Target surface form: other
Context:
There also are reports from several labs, as yet unpublished, of missing p53 genes in tissue taken from kidney, brain and skin cancers. At the same time, the Johns Hopkins team and others are rushing to pinpoint other tumor-suppressor genes. Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer. Recently, he and others reported that the retinoblastoma suppressor gene may also be involved in some lung cancers, as well as several <t>other</t> more common cancers, too. Where these discoveries will lead, scientists can only speculate.

Candidate senses:
1. sense_key=other%3:00:00:: | definition=not the same one or ones already mentioned or implied; - the White Queen | examples=today isn't any other day; the construction of highways and other public works
2. sense_key=other%5:00:00:past:00 | definition=recently past | examples=the other evening
3. sense_key=other%5:00:02:past:00 | definition=belonging to the distant past | synonyms=early, former | examples=the early inhabitants of Europe; former generations
4. sense_key=other%5:00:00:strange:00 | definition=very unusual; different in character or quality from the normal or expected; - Lance Morrow | examples=a strange, other dimension...where his powers seemed to fail

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{
  "sense_index": 1
}
```

content:
```json
{
  "sense_index": 1
}
```

reasoning_content:
Okay, here's my interpretation of that word "other" in this specific context, as if it were my own thought process:

**Deconstructing "Other" in Cancer Context**

Alright, the target word is "other" in that phrase about cancer. It's used in the sentence "as well as several other more common cancers, too," so my immediate instinct is to parse that. It's pretty straightforward, but it's important to be exact. "Other" here clearly indicates *additional* cancers. It's not referring back to or being synonymous with the ones already cited. It's additive, expanding the scope of the discussion.

Thinking more broadly, I'd say the relevant sense here is, unequivocally, Sense 1: "not the same one or ones already mentioned or implied." That's the core of its meaning. The sentence is saying there are these specific cancers, and then, importantly, there are *more* cancers – different cancers. It's akin to saying "today isn't any other day," or even something like "the construction of highways and other public works" – clearly there are highways, and then there are *different* public works. It's a fundamental distinction. I'd need to go into more detail to consider the specifics of that word, but in this context, the definition is clear.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: more
Target surface form: more
Context:
There also are reports from several labs, as yet unpublished, of missing p53 genes in tissue taken from kidney, brain and skin cancers. At the same time, the Johns Hopkins team and others are rushing to pinpoint other tumor-suppressor genes. Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer. Recently, he and others reported that the retinoblastoma suppressor gene may also be involved in some lung cancers, as well as several other <t>more</t> common cancers, too. Where these discoveries will lead, scientists can only speculate.

Candidate senses:
1. sense_key=more%4:02:00:: | definition=used to form the comparative of some adjectives and adverbs | synonyms=to a greater extent | examples=more interesting; more beautiful
2. sense_key=more%4:02:01:: | definition=comparative of much; to a greater degree or extent | examples=he works more now; they eat more than they should

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
Here's my analysis of the word "more" in that context:

**"More" in the phrase "more common"**

Okay, so the target is "more" in the phrase "several other more common cancers." I need to determine the intended sense. "More" modifies "common," so it's a comparative relationship I'm looking at. I quickly run through the likely senses.

Sense 1: Definitely the primary contender - it forms the comparative of adjectives and adverbs. Think "more interesting," "more beautiful." This is most likely.

Sense 2: The other sense is the comparative of "much," indicating a greater degree or extent, as in "he works more now." This is possible, but less direct in this case.

Given the context, "more" is clearly acting as a degree modifier, forming the comparative of the adjective "common." It's directly comparing the frequency or prevalence of the cancers, indicating those mentioned are *more* frequent than others. So, it's definitively Sense 1, the comparative form.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: common
Target surface form: common
Context:
There also are reports from several labs, as yet unpublished, of missing p53 genes in tissue taken from kidney, brain and skin cancers. At the same time, the Johns Hopkins team and others are rushing to pinpoint other tumor-suppressor genes. Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer. Recently, he and others reported that the retinoblastoma suppressor gene may also be involved in some lung cancers, as well as several other more <t>common</t> cancers, too. Where these discoveries will lead, scientists can only speculate.

Candidate senses:
1. sense_key=common%3:00:02:: | definition=belonging to or participated in by a community as a whole; public | examples=for the common good; common lands are set aside for use by all members of a community
2. sense_key=common%3:00:01:: | definition=having no special distinction or quality; widely known or commonly encountered; average or ordinary or usual | examples=the common man; a common sailor
3. sense_key=common%5:00:00:shared:00 | definition=common to or shared by two or more parties | synonyms=mutual | examples=a common friend; the mutual interests of management and labor
4. sense_key=common%5:00:00:familiar:02 | definition=commonly encountered | synonyms=usual | examples=a common (or familiar) complaint; the usual greeting
5. sense_key=common%5:00:00:informal:02 | definition=being or characteristic of or appropriate to everyday language | synonyms=vernacular, vulgar | examples=common parlance; a vernacular term
6. sense_key=common%5:00:00:lowborn:00 | definition=of or associated with the great masses of people | synonyms=plebeian, vulgar, unwashed | examples=the common people in those days suffered greatly; behavior that branded him as common
7. sense_key=common%5:00:00:inferior:02 | definition=of low or inferior quality or value; - Shakespeare | synonyms=coarse | examples=of what coarse metal ye are molded; produced...the common cloths used by the poorer population
8. sense_key=common%5:00:00:unrefined:01 | definition=lacking refinement or cultivation or taste | synonyms=coarse, rough-cut, uncouth, vulgar | examples=he had coarse manners but a first-rate mind; behavior that branded him as common
9. sense_key=common%5:00:00:ordinary:00 | definition=to be expected; standard | examples=common decency

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 4}
```

content:
```json
{"sense_index": 4}
```

reasoning_content:
**Analyzing the Nuances of "Common"**

Okay, so the target word here is "common," specifically in the phrase "several other more common cancers, too." My immediate focus is on which sense of "common" is intended. I quickly run through the possibilities in my mind: public or community-based (unlikely here), average or ordinary (a possibility, but needs further scrutiny), mutual or shared (doesn't quite fit), and then finally, the one that resonates most strongly, "commonly encountered" or "usual."

Thinking through it further, that fourth sense, "commonly encountered," directly relates to the frequency of occurrence. "Commonly encountered" *is* about how often something happens. I'm going to test that hypothesis. Let's see... the definition I have access to is "commonly encountered," and the examples provided include "a common (or familiar) complaint; the usual greeting". Bingo.

If we apply this definition to "more common cancers," the phrase translates to "cancers that occur more frequently." That, intuitively, seems like the most logical interpretation. This is a clear case of semantic disambiguation, and Sense 4, "commonly encountered," is the clear winner.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancers
Context:
There also are reports from several labs, as yet unpublished, of missing p53 genes in tissue taken from kidney, brain and skin cancers. At the same time, the Johns Hopkins team and others are rushing to pinpoint other tumor-suppressor genes. Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer. Recently, he and others reported that the retinoblastoma suppressor gene may also be involved in some lung cancers, as well as several other more common <t>cancers</t>, too. Where these discoveries will lead, scientists can only speculate.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
Okay, here's my interpretation of this definition, tailored as if I, an expert in my field, am processing this information:

**Understanding the Term "Cancers"**

Alright, so the text explicitly frames "cancers" within the context of malignant tumors and diseases. We're talking specifically about conditions like "lung cancers" and "more common cancers" here. This signals the precise usage we're dealing with. It's not a generic term, but directly referring to those life-threatening cellular aberrations.

The core definition, as I understand it from the context, is that *any* malignant growth or tumor falls under this umbrella. It's all about uncontrolled, abnormal cell division. That's the key: it doesn't matter the specific cell type or location; if the cells are dividing erratically, invasively, and without normal regulatory processes, then we're dealing with cancer. The sense key reinforces this — it's *the* definition of cancer as a specific disease entity.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: discovery
Target surface form: discoveries
Context:
At the same time, the Johns Hopkins team and others are rushing to pinpoint other tumor-suppressor genes. Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer. Recently, he and others reported that the retinoblastoma suppressor gene may also be involved in some lung cancers, as well as several other more common cancers, too. Where these <t>discoveries</t> will lead, scientists can only speculate. Already two major pharmaceutical companies, the Squibb unit of Bristol-Myers Squibb Co. and Hoffmann-La Roche Inc., are collaborating with gene hunters to turn the anticipated cascade of discoveries into predictive tests and, maybe, new therapies.

Candidate senses:
1. sense_key=discovery%1:04:00:: | definition=the act of discovering something | synonyms=find, uncovering
2. sense_key=discovery%1:10:00:: | definition=something that is discovered
3. sense_key=discovery%1:09:00:: | definition=a productive insight | synonyms=breakthrough, find
4. sense_key=discovery%1:10:01:: | definition=(law) compulsory pretrial disclosure of documents relevant to a case; enables one side in a litigation to elicit information from the other side concerning the facts in the case

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: only
Target surface form: only
Context:
At the same time, the Johns Hopkins team and others are rushing to pinpoint other tumor-suppressor genes. Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer. Recently, he and others reported that the retinoblastoma suppressor gene may also be involved in some lung cancers, as well as several other more common cancers, too. Where these discoveries will lead, scientists can <t>only</t> speculate. Already two major pharmaceutical companies, the Squibb unit of Bristol-Myers Squibb Co. and Hoffmann-La Roche Inc., are collaborating with gene hunters to turn the anticipated cascade of discoveries into predictive tests and, maybe, new therapies.

Candidate senses:
1. sense_key=only%4:02:02:: | definition=and nothing more | synonyms=merely, simply, just, but | examples=I was merely asking; it is simply a matter of time
2. sense_key=only%4:02:01:: | definition=without any others being included or involved | synonyms=entirely, exclusively, solely, alone | examples=was entirely to blame; a school devoted entirely to the needs of problem children
3. sense_key=only%4:02:00:: | definition=with nevertheless the final result | examples=He arrived only to find his wife dead; We won only to lose again in the next round
4. sense_key=only%4:02:04:: | definition=in the final outcome | examples=These news will only make you more upset
5. sense_key=only%4:02:06:: | definition=except that | examples=It was the same story; only this time she came out better
6. sense_key=only%4:02:03:: | definition=never except when | synonyms=only if, only when | examples=call me only if your cold gets worse
7. sense_key=only%4:02:05:: | definition=as recently as | examples=I spoke to him only an hour ago

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
Okay, here's my interpretation of that thought process, tailored for an expert audience:

**Analyzing the Nuances of "Only"**

Alright, the key word here is "only," specifically in the phrase "scientists can only speculate." My immediate reaction is to parse the possible senses of "only" because this is crucial for accurate interpretation. We're dealing with the constraints on what scientists *can* do.

Let's break it down: "Only" implies a limitation. It suggests that speculation is the *sole* action. Therefore the meaning can be, "merely" speculate, "simply/just" speculate. Or, we could consider "and nothing more," suggesting a lack of certainty and limited action.

However, we need to consider other readings. Could "only" mean "without any others being included or involved?" This would be a very different reading; that scientists *alone* are speculating, perhaps in contrast to collaboration.

Considering the context of speculation, sense 1, "and nothing more," fits far better than sense 2. It captures the idea that they can just, simply, speculate.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: speculate
Target surface form: speculate
Context:
At the same time, the Johns Hopkins team and others are rushing to pinpoint other tumor-suppressor genes. Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer. Recently, he and others reported that the retinoblastoma suppressor gene may also be involved in some lung cancers, as well as several other more common cancers, too. Where these discoveries will lead, scientists can only <t>speculate</t>. Already two major pharmaceutical companies, the Squibb unit of Bristol-Myers Squibb Co. and Hoffmann-La Roche Inc., are collaborating with gene hunters to turn the anticipated cascade of discoveries into predictive tests and, maybe, new therapies.

Candidate senses:
1. sense_key=speculate%2:31:01:: | definition=to believe especially on uncertain or tentative grounds | synonyms=theorize, theorise, conjecture, hypothesize, hypothesise, hypothecate | examples=Scientists supposed that large dinosaurs lived in swamps
2. sense_key=speculate%2:32:00:: | definition=talk over conjecturally, or review in an idle or casual way and with an element of doubt or without sufficient reason to reach a conclusion | examples=We were speculating whether the President had to resign after the scandal
3. sense_key=speculate%2:31:00:: | definition=reflect deeply on a subject | synonyms=chew over, think over, meditate, ponder, excogitate, contemplate | examples=I mulled over the events of the afternoon; philosophers have speculated on the question of God for thousands of years
4. sense_key=speculate%2:40:00:: | definition=invest at a risk | synonyms=job | examples=I bought this house not because I want to live in it but to sell it later at a good price, so I am speculating

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Nuances of "Speculate"**

Okay, so the target word is "speculate" in the phrase "Where these discoveries will lead, scientists can only speculate." My mind immediately jumps to the possible senses, considering the context. First, there's that core meaning of *believing* on uncertain ground, basically to theorize, conjecture, or hypothesize. Then, there's the more communicative sense: talking something over in a doubtful or casual way. A third sense, though it feels less relevant here, is deep reflection. Finally, there is a fourth sense, relating to investment at risk, but that feels very distant from this context.

Given that "Where these discoveries will lead..." implies a scientific context, my initial instinct is that the first two senses are most relevant: formulating a theory, or discussing possibilities. I often see "speculate on/about" or just "speculate" in scientific literature referring to that first cognitive sense. I need to make sure I am separating the cognitive act from the communication of the act.

Wait, let me consult WordNet to confirm my thoughts. WordNet distinguishes the senses: `speculate%2:31:01::` is *theorize, conjecture, hypothesize* (cognition), and `speculate%2:32:00::` is *talk over conjecturally* (communication). Okay, that's helpful. Now, considering the original phrase, "Where these discoveries will lead, scientists can only speculate" feels most like forming a *guess* or *hypothesis*. This clearly leans towards a primarily cognitive process, although communication could then result.

Let's refine this, focusing on the first sense: "to believe especially on uncertain or tentative grounds". That's it! That fits perfectly. Scientists can only *guess, hypothesize, or conjecture* about the future implications of these discoveries. Sense 1 is the clear winner here.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: major
Target surface form: major
Context:
Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer. Recently, he and others reported that the retinoblastoma suppressor gene may also be involved in some lung cancers, as well as several other more common cancers, too. Where these discoveries will lead, scientists can only speculate. Already two <t>major</t> pharmaceutical companies, the Squibb unit of Bristol-Myers Squibb Co. and Hoffmann-La Roche Inc., are collaborating with gene hunters to turn the anticipated cascade of discoveries into predictive tests and, maybe, new therapies. Some researchers say new cancer drugs to slow or reverse tumor growth may be based on the suppressor proteins normally produced by the genes.

Candidate senses:
1. sense_key=major%3:00:06:: | definition=of greater importance or stature or rank | examples=a major artist; a major role
2. sense_key=major%3:00:02:: | definition=greater in scope or effect | examples=a major contribution; a major improvement
3. sense_key=major%3:00:01:: | definition=greater in number or size or amount | examples=a major portion (a majority) of the population; Ursa Major
4. sense_key=major%3:00:05:: | definition=of the field of academic study in which one concentrates or specializes | examples=his major field was mathematics
5. sense_key=major%3:00:04:: | definition=of a scale or mode | examples=major scales; the key of D major
6. sense_key=major%3:00:07:: | definition=of greater seriousness or danger | examples=a major earthquake; a major hurricane
7. sense_key=major%3:00:03:: | definition=of full legal age
8. sense_key=major%5:00:00:senior:00 | definition=of the elder of two boys with the same family name | examples=Jones major

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: unit
Target surface form: unit
Context:
Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer. Recently, he and others reported that the retinoblastoma suppressor gene may also be involved in some lung cancers, as well as several other more common cancers, too. Where these discoveries will lead, scientists can only speculate. Already two major pharmaceutical companies, the Squibb <t>unit</t> of Bristol-Myers Squibb Co. and Hoffmann-La Roche Inc., are collaborating with gene hunters to turn the anticipated cascade of discoveries into predictive tests and, maybe, new therapies. Some researchers say new cancer drugs to slow or reverse tumor growth may be based on the suppressor proteins normally produced by the genes.

Candidate senses:
1. sense_key=unit%1:23:00:: | definition=any division of quantity accepted as a standard of measurement or exchange | synonyms=unit of measurement | examples=the dollar is the United States unit of currency; a unit of wheat is a bushel
2. sense_key=unit%1:24:00:: | definition=an individual or group or structure or other entity regarded as a structural or functional constituent of a whole | examples=the reduced the number of units and installations; the word is a basic linguistic unit
3. sense_key=unit%1:14:00:: | definition=an organization regarded as part of a larger social group | synonyms=social unit | examples=the coach said the offensive unit did a good job; after the battle the soldier had trouble rejoining his unit
4. sense_key=unit%1:09:00:: | definition=a single undivided whole | examples=an idea is not a unit that can be moved from one brain to another
5. sense_key=unit%1:17:00:: | definition=a single undivided natural thing occurring in the composition of something else | synonyms=building block | examples=units of nucleic acids
6. sense_key=unit%1:03:00:: | definition=an assemblage of parts that is regarded as a single entity | synonyms=whole | examples=how big is that part compared to the whole?; the team is a unit

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
Okay, here's my interpretation of that thought process, tailored for an expert audience:

**Analyzing "Unit" in a Corporate Context**

Alright, the target word is "unit," specifically in the context of "the Squibb unit of Bristol-Myers Squibb Co." My immediate focus, as expected, is on the organizational sense. It's almost certain we're not dealing with a physical measure or some other technical definition. The key here is understanding the relationship within a larger corporate structure.

My analysis zeroes in on that third sense in my mental lexicon: "an organization regarded as part of a larger social group." In this case, "social group" is a bit of a placeholder, of course. The *real* relationship is purely organizational. The "Squibb unit" is almost certainly a division, subsidiary, or some similarly structured component *within* the overall Bristol-Myers Squibb Company. The "unit" designation implies a degree of operational autonomy or specialization, while still being inextricably linked to, and under the control of, the parent company. I’d be interested to investigate further to confirm if the Squibb unit has a distinct business function that supports the larger parent company.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: collaborate
Target surface form: collaborating
Context:
Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer. Recently, he and others reported that the retinoblastoma suppressor gene may also be involved in some lung cancers, as well as several other more common cancers, too. Where these discoveries will lead, scientists can only speculate. Already two major pharmaceutical companies, the Squibb unit of Bristol-Myers Squibb Co. and Hoffmann-La Roche Inc., are <t>collaborating</t> with gene hunters to turn the anticipated cascade of discoveries into predictive tests and, maybe, new therapies. Some researchers say new cancer drugs to slow or reverse tumor growth may be based on the suppressor proteins normally produced by the genes.

Candidate senses:
1. sense_key=collaborate%2:41:00:: | definition=work together on a common enterprise of project | synonyms=join forces, cooperate, get together | examples=The soprano and the pianist did not get together very well; We joined forces with another research group
2. sense_key=collaborate%2:41:01:: | definition=cooperate as a traitor | examples=he collaborated with the Nazis when they occupied Paris

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
Okay, here's my take on those thoughts, framed as my own:

**Analyzing "Collaborating" in the Pharma-Gene Hunt Context**

Alright, the target word is "collaborating," and we're looking at it within the framework of pharma companies partnering with gene hunters – a classic scenario for developing predictive tests and new therapies. My immediate task is to nail down the precise sense of "collaborating" here. It's crucial to disambiguate.

My mind immediately jumps to two candidate senses. The first, and the obvious frontrunner, is the sense of *working together on a common enterprise or project*. That feels right, it aligns with the strategic alliance we're envisioning. We're talking about a joint effort, shared goals. Pharma brings resources, regulatory expertise, and a market presence; gene hunters bring their expertise in genomics, target discovery, and perhaps novel technologies. It's a classic synergy.

Then, there's the less likely but always present "cooperate as a traitor" sense. Given the context of a potential, mutually beneficial partnership, it's quickly dismissed. This sense would be completely off-base and not supported by the broader idea of pharma companies working with others.

So, I'm confidently landing on the first sense: **"working together on a common enterprise or project"** is the clear and intended meaning here. The language of collaboration is a cornerstone in this scenario.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: hunter
Target surface form: hunters
Context:
Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer. Recently, he and others reported that the retinoblastoma suppressor gene may also be involved in some lung cancers, as well as several other more common cancers, too. Where these discoveries will lead, scientists can only speculate. Already two major pharmaceutical companies, the Squibb unit of Bristol-Myers Squibb Co. and Hoffmann-La Roche Inc., are collaborating with gene <t>hunters</t> to turn the anticipated cascade of discoveries into predictive tests and, maybe, new therapies. Some researchers say new cancer drugs to slow or reverse tumor growth may be based on the suppressor proteins normally produced by the genes.

Candidate senses:
1. sense_key=hunter%1:18:00:: | definition=someone who hunts game | synonyms=huntsman
2. sense_key=hunter%1:18:01:: | definition=a person who searches for something | examples=a treasure hunter
3. sense_key=hunter%1:17:00:: | definition=a constellation on the equator to the east of Taurus; contains Betelgeuse and Rigel | synonyms=Orion
4. sense_key=hunter%1:06:00:: | definition=a watch with a hinged metal lid to protect the crystal | synonyms=hunting watch

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
Okay, here's my interpretation of those thoughts, summarized from my perspective as an expert in my field:

**Decoding "Gene Hunters"**

Alright, let's break this down. When I see the term "gene hunters," my mind immediately jumps to the implication of an active search. We're not just passively observing; we're actively *looking* for something specific within the realm of genetics. It's a very evocative term, isn't it? It frames the whole endeavor with a sense of adventure, of pursuit, a hunt for a specific gene.

My understanding of the term is that there are *two* key components; those who work to discover something new, and a general search for something, just as a 'treasure hunter' would actively hunt for a treasure. It's a direct parallel. It suggests a focused investigation, perhaps a deliberate research process, not just happenstance discovery. The 'something' could be a specific gene of interest. I'm imagining a concerted effort, maybe involving experimental design, data analysis, and all the rigor that goes along with any kind of scientific research. It is more than just searching.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: turn
Target surface form: turn
Context:
Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer. Recently, he and others reported that the retinoblastoma suppressor gene may also be involved in some lung cancers, as well as several other more common cancers, too. Where these discoveries will lead, scientists can only speculate. Already two major pharmaceutical companies, the Squibb unit of Bristol-Myers Squibb Co. and Hoffmann-La Roche Inc., are collaborating with gene hunters to <t>turn</t> the anticipated cascade of discoveries into predictive tests and, maybe, new therapies. Some researchers say new cancer drugs to slow or reverse tumor growth may be based on the suppressor proteins normally produced by the genes.

Candidate senses:
1. sense_key=turn%2:38:00:: | definition=change orientation or direction, also in the abstract sense | examples=Turn towards me; The mugger turned and fled before I could see his face
2. sense_key=turn%2:30:04:: | definition=undergo a transformation or a change of position or action | synonyms=change state | examples=We turned from Socialism to Capitalism; The people turned against the President when he stole the election
3. sense_key=turn%2:42:00:: | definition=undergo a change or development | synonyms=become | examples=The water turned into ice; Her former friend became her worst enemy
4. sense_key=turn%2:38:02:: | definition=cause to move around or rotate | examples=turn a key; turn your palm this way
5. sense_key=turn%2:30:00:: | definition=change to the contrary | synonyms=change by reversal, reverse | examples=The trend was reversed; the tides turned against him
6. sense_key=turn%2:38:03:: | definition=pass to the other side of | synonyms=move around | examples=turn the corner; move around the obstacle
7. sense_key=turn%2:30:03:: | definition=pass into a condition gradually, take on a specific property or attribute; become | synonyms=grow | examples=The weather turned nasty; She grew angry
8. sense_key=turn%2:35:08:: | definition=let (something) fall or spill from a container | synonyms=release | examples=turn the flour onto a plate
9. sense_key=turn%2:38:04:: | definition=move around an axis or a center | examples=The wheels are turning
10. sense_key=turn%2:38:01:: | definition=cause to move around a center so as to show another side of | synonyms=turn over | examples=turn a page of a book
11. sense_key=turn%2:38:06:: | definition=to send or let go | examples=They turned away the crowd at the gate of the governor's mansion
12. sense_key=turn%2:36:00:: | definition=to break and turn over earth especially with a plow | synonyms=plow, plough | examples=Farmer Jones plowed his east field last week; turn the earth in the Spring
13. sense_key=turn%2:35:06:: | definition=shape by rotating on a lathe or cutting device or a wheel | examples=turn the legs of the table; turn the clay on the wheel
14. sense_key=turn%2:30:09:: | definition=change color | examples=In Vermont, the leaves turn early
15. sense_key=turn%2:29:00:: | definition=twist suddenly so as to sprain | synonyms=twist, sprain, wrench, wrick, rick | examples=wrench one's ankle; The wrestler twisted his shoulder
16. sense_key=turn%2:42:13:: | definition=cause to change or turn into something different;assume new characteristics | examples=The princess turned the frog into a prince by kissing him; The alchemists tried to turn lead into gold
17. sense_key=turn%2:41:10:: | definition=accomplish by rotating | examples=turn a somersault; turn cartwheels
18. sense_key=turn%2:40:13:: | definition=get by buying and selling | examples=the company turned a good profit after a year
19. sense_key=turn%2:38:13:: | definition=cause to move along an axis or into a new direction | examples=turn your face to the wall; turn the car around
20. sense_key=turn%2:38:14:: | definition=channel one's attention, interest, thought, or attention toward or away from something | examples=The pedophile turned to boys for satisfaction; people turn to mysticism at the turn of a millennium
21. sense_key=turn%2:35:11:: | definition=cause (a plastic object) to assume a crooked or angular form | synonyms=flex, bend, deform, twist | examples=bend the rod; twist the dough into a braid
22. sense_key=turn%2:35:10:: | definition=alter the functioning or setting of | examples=turn the dial to 10; turn the heat down
23. sense_key=turn%2:33:13:: | definition=direct at someone | examples=She turned a smile on me; They turned their flashlights on the car
24. sense_key=turn%2:32:14:: | definition=have recourse to or make an appeal or request for help or information to | synonyms=call on | examples=She called on her Representative to help her; She turned to her relatives for help
25. sense_key=turn%2:30:01:: | definition=go sour or spoil | synonyms=sour, ferment, work | examples=The milk has soured; The wine worked
26. sense_key=turn%2:30:14:: | definition=become officially one year older | examples=She is turning 50 this year

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 16}
```

content:
```json
{"sense_index": 16}
```

reasoning_content:
Okay, here's my interpretation of that word "turn" in the given context, delivered as a first-person summary geared towards an expert:

**Deconstructing "Turn" in a Translational Context**

Alright, let's unpack this "turn" here. My initial focus is on its transitivity within the phrase: "...to *turn* the anticipated cascade of discoveries into predictive tests...". My instinct is to zero in on the causative aspect, the notion of *transformation*. I'm thinking about how the act of "turning" is about creating a deliberate shift. Specifically, we're not just looking at a simple rearrangement; it's a *conversion* or *metamorphosis*.

The examples that immediately come to mind are the classic alchemical ones – "turn lead into gold," or the fairytale trope of "turn the frog into a prince". They embody the essence of *causing* a change, a fundamental alteration from one state or form to another. That is, taking one thing and using an intermediary process to create another distinct thing.

Therefore, within this context, "turn" is best understood as a purposeful manipulation of raw research findings, transforming them into something applicable and useful: predictive tests. This isn't just about discovery; it's about the purposeful application and exploitation of it to make something useful. It's about taking the *potential* of the "anticipated cascade of discoveries" and rendering them into an applied tool – a predictive test. The implied action here is that, without action, those discoveries would remain unexploited.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: discovery
Target surface form: discoveries
Context:
Dr. Vogelstein hopes soon to isolate one on chromosome 18, also involved in colon cancer. Ray White in Utah and Walter Bodmer, a researcher in Great Britain, are close to finding another gene involved with some types of colon cancer, thought to be on chromosome 5. Dr. Minna believes people who inherit a defective gene somewhere on one of their two copies of chromosome 3 are especially prone to lung cancer. Recently, he and others reported that the retinoblastoma suppressor gene may also be involved in some lung cancers, as well as several other more common cancers, too. Where these discoveries will lead, scientists can only speculate. Already two major pharmaceutical companies, the Squibb unit of Bristol-Myers Squibb Co. and Hoffmann-La Roche Inc., are collaborating with gene hunters to turn the anticipated cascade of <t>discoveries</t> into predictive tests and, maybe, new therapies. Some researchers say new cancer drugs to slow or reverse tumor growth may be based on the suppressor proteins normally produced by the genes.

Candidate senses:
1. sense_key=discovery%1:04:00:: | definition=the act of discovering something | synonyms=find, uncovering
2. sense_key=discovery%1:10:00:: | definition=something that is discovered
3. sense_key=discovery%1:09:00:: | definition=a productive insight | synonyms=breakthrough, find
4. sense_key=discovery%1:10:01:: | definition=(law) compulsory pretrial disclosure of documents relevant to a case; enables one side in a litigation to elicit information from the other side concerning the facts in the case

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```