[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: dose
Target surface form: dose
Context:
Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended <t>dose</t> of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes.

Candidate senses:
1. sense_key=dose%1:06:00:: | definition=a measured portion of medicine taken at any one time | synonyms=dosage
2. sense_key=dose%1:23:00:: | definition=the quantity of an active agent (substance or radiation) taken in or absorbed at any one time | synonyms=dosage
3. sense_key=dose%1:26:00:: | definition=a communicable infection transmitted by sexual intercourse or genital contact | synonyms=venereal disease, VD, venereal infection, social disease, Cupid's itch, Cupid's disease
4. sense_key=dose%1:06:01:: | definition=street name for lysergic acid diethylamide | synonyms=acid, back breaker, battery-acid, dot, Elvis, loony toons

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**My Analysis of "dose" in a Medical Context**

Okay, here's what I've got. I need to pinpoint the correct WordNet sense for "dose" in this context: "The recommended dose of Alimta is 500 mg per square metre of body surface area." My initial candidates are sense 1 (a measured portion of medicine), sense 2 (the quantity of an active agent), and two irrelevant senses.

The question is, does this "dose" refer to the *physical portion* of the drug or the *amount/quantity*? Let's break down the WordNet definitions and how the word is actually used.  Sense 1, a noun.artifact, is defined as "a measured portion of medicine taken at any one time."  Sense 2, a noun.quantity, is "the quantity of an active agent (substance or radiation) taken in or absorbed at any one time." The sentence explicitly states "500 mg," which sounds like a quantity.

My initial thought is to consider hypernyms in WordNet.  Sense 1 is linked to "medicine," an artifact, while sense 2 relates to "quantity."  But in the example sentence "500 mg is directly a measure/quantity!" I should check if dose%1:06:00:: has hypernyms. I remember now: dose is under medicine in WordNet because medicines are artifacts! So a dose of medicine is, effectively, the medicine itself.

Okay, let's look at the usage examples.  The wording of the definition is important: "a *measured* portion of medicine."  That "measured" is key. A measured *portion* of medicine *is* an amount. In this context, Alimta is explicitly a medicine, and the sentence clearly talks about a quantity – 500mg. It's a measured amount *of* that medicine!

I will do a final check of SemCor examples to guide my decision: I remember seeing examples in SemCor: "a lethal dose of" vs. "a dose of penicillin".  And "a single dose," "the dose".

I see that there are more occurrences of dose%1:06:00:: (14 instances) than dose%1:23:00:: (3 instances) in SemCor. This strongly suggests which sense is most common. And then there are things like "dose of penicillin" or "a daily dose."

I recall that in SemCor when "dose" refers to *medicine* or *drug*, it's tagged with sense 1. Sense 2 (quantity) is really for radiation or other absorbed substances.

The provided text comes from a patient information document. It's medical.  Given that Alimta is medicine, and that the text refers to this is a "recommended dose," then according to the standard clinical terminology a "dose of medicine" is the thing that the patient takes.

So, despite the quantity aspect, the best fit is sense 1. It is a "measured *portion* of medicine", which is the medicine itself, and not a bare quantity.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: mg
Target surface form: mg
Context:
Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 <t>mg</t> per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes.

Candidate senses:
1. sense_key=mg%1:23:00:: | definition=one thousandth (1/1,000) gram | synonyms=milligram
2. sense_key=mg%1:27:00:: | definition=a light silver-white ductile bivalent metallic element; in pure form it burns with brilliant white flame; occurs naturally only in combination (as in magnesite and dolomite and carnallite and spinel and olivine) | synonyms=magnesium, atomic number 12

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

finish_reason: stop

content:
```json
{"sense_index": 1}
```

role: assistant

reasoning_content:
Here's my analysis of the situation:

**Disambiguating "mg"**

Alright, the target word is "mg". Immediately, I know this is ripe for potential ambiguity, as "mg" could represent either milligram or magnesium. I need to figure out which is intended in the context I'm given: "The recommended dose of Alimta is 500 mg per square metre of body surface area..."

My immediate thought is to consider the two senses. Sense 1, milligram, represents one-thousandth of a gram and functions as a unit of mass/weight. Sense 2, magnesium, is the chemical element with atomic number 12.

Given the phrase "500 mg per square metre," the context strongly suggests a unit of measurement related to dosage or concentration. "Per square metre" indicates a measure of surface area. I can immediately discard magnesium as a plausible meaning; it wouldn't make sense to express a chemical element in such a unit. Instead, the "mg" almost certainly refers to milligram. Specifically, it specifies the mass or weight of the medication (Alimta) to be administered.

Therefore, sense 1, milligram, is the correct interpretation. This is a pretty straightforward disambiguation, given my experience.

type: thinking

service_tier: default

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: body
Target surface form: body
Context:
Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of <t>body</t> surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes.

Candidate senses:
1. sense_key=body%1:08:00:: | definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
2. sense_key=body%1:14:00:: | definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium; the student body
3. sense_key=body%1:08:02:: | definition=a natural object consisting of a dead animal or person | synonyms=dead body | examples=they found the body in the lake
4. sense_key=body%1:17:00:: | definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. sense_key=body%1:08:01:: | definition=the body excluding the head and neck and limbs | synonyms=torso, trunk | examples=they moved their arms and legs and bodies
6. sense_key=body%1:14:02:: | definition=a collection of particulars considered as a system | examples=a body of law; a body of doctrine
7. sense_key=body%1:07:00:: | definition=the property of holding together and retaining its shape | synonyms=consistency, consistence, eubstance | examples=wool has more body than rayon; when the dough has enough consistency it is ready to bake
8. sense_key=body%1:10:00:: | definition=the central message of a communication | examples=the body of the message was short
9. sense_key=body%1:07:01:: | definition=the main mass of a thing
10. sense_key=body%1:06:01:: | definition=a resonating chamber in a musical instrument (as the body of a violin) | synonyms=soundbox
11. sense_key=body%1:06:00:: | definition=the external structure of a vehicle | examples=the body of the car was badly rusted

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Semantic Range of "Body" in a Pharmaceutical Context**

Okay, let's break this down. The task is to identify the most appropriate sense of "body" within this specific context: "The recommended dose of Alimta is 500 mg per square metre of *body* surface area (calculated using the patient's height and weight)..." Right, so we're dealing with *body surface area*.

I've been presented with a list of candidate senses, and my initial thought is, based on the phrase itself, we're likely referring to the physical structure of the *patient*. Let's quickly go through the definitions.

*   **Sense 1: body%1:08:00:: - the entire structure of an organism (an animal, plant, or human being) (organic structure, physical structure)**. This immediately jumps out as a strong contender. "Entire structure" aligns directly with the concept of the complete surface area of a *human*.
*   **Sense 2: body%1:14:00:: - a group of persons associated by some common tie or occupation and regarded as an entity**. This doesn't seem relevant. We're not discussing a collective group here.
*   **Sense 3: body%1:08:02:: - a natural object consisting of a dead animal or person (dead body)**. Obviously, this is irrelevant. This is a medical context referring to a living being.
*   **Sense 4: body%1:17:00:: - an individual 3-dimensional object that has mass and that is distinguishable from other objects**. While technically accurate, it's too general.
*   **Sense 5: body%1:08:01:: - the body excluding the head and neck and limbs (torso, trunk)**. This is a partial body, and we're dealing with the entire surface area.
*   **Sense 6: body%1:14:02:: - a collection of particulars considered as a system**. This is too abstract, and does not align.
*   **Sense 7: body%1:07:00:: - the property of holding together and retaining its shape**. Again, not relevant.
*   **Sense 8: body%1:10:00:: - the central message of a communication**. Definitely not.
*   **Sense 9: body%1:07:01:: - the main mass of a thing**. Again too general.
*   **Sense 10: body%1:06:01:: - a resonating chamber in a musical instrument**. No, not a musical instrument.
*   **Sense 11: body%1:06:00:: - the external structure of a vehicle**. No.

Therefore, after reviewing each of the definitions, it's clear that **Sense 1** is the most precise and appropriate. We're talking about the complete physical structure, the organism, the entire surface area of the human. "Body surface area" directly implies this sense.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: calculate
Target surface form: calculated
Context:
Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (<t>calculated</t> using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes.

Candidate senses:
1. sense_key=calculate%2:31:00:: | definition=make a mathematical calculation or computation | synonyms=cipher, cypher, compute, work out, reckon, figure
2. sense_key=calculate%2:31:03:: | definition=judge to be probable | synonyms=estimate, reckon, count on, figure, forecast
3. sense_key=calculate%2:40:00:: | definition=keep an account of | synonyms=account
4. sense_key=calculate%2:32:01:: | definition=predict in advance | synonyms=forecast
5. sense_key=calculate%2:31:02:: | definition=specifically design a product, event, or activity for a certain public | synonyms=aim, direct
6. sense_key=calculate%2:31:05:: | definition=have faith or confidence in | synonyms=count, bet, depend, look, reckon | examples=you can count on me to help you any time; Look to your friends for support

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Meaning of "Calculated"**

Okay, so the word "calculated" is the key here, and I need to determine its specific meaning within this pharmaceutical context. The sentence is about a recommended Alimta dose being determined based on body surface area, which itself is *calculated* using height and weight. Let's break down the potential senses:

First, there's the core meaning of making a mathematical *calculation* – this seems highly relevant, given we're talking about a formula. Then there's the sense of *estimation* or judging probability. Could it be that? I don't think so, based on the context. Next we have accounting, which seems off, as well as forecasting and designing something for a specific public. Neither of those fits. Finally there's the sense of having faith in someone. No.

Given that body surface area is mathematically derived from height and weight using a formula, sense 1, "make a mathematical calculation or computation", is the only correct answer. It's the most precise and appropriate meaning within this specific pharmaceutical context.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: using
Context:
Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated <t>using</t> the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes.

Candidate senses:
1. sense_key=use%2:34:01:: | definition=put into service; make work or employ for a particular purpose or for its inherent or natural purpose | synonyms=utilize, utilise, apply, employ | examples=use your head!; we only use Spanish at home
2. sense_key=use%2:34:02:: | definition=take or consume (regularly or habitually) | synonyms=habituate | examples=She uses drugs rarely
3. sense_key=use%2:34:00:: | definition=use up, consume fully | synonyms=expend | examples=The legislature expended its time on school questions
4. sense_key=use%2:41:14:: | definition=seek or achieve an end by using to one's advantage | examples=She uses her influential friends to get jobs; The president's wife used her good connections
5. sense_key=use%2:41:04:: | definition=avail oneself to | synonyms=practice, apply | examples=apply a principle; practice a religion
6. sense_key=use%2:41:03:: | definition=habitually do something (use only in the past tense) | examples=She used to call her mother every week but now she calls only occasionally; I used to get sick when I ate in that dining hall

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Meaning of "Using" in Context**

Okay, so the target word is "using," and it's in the sentence "The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient's height and weight)." My initial step is always to go straight to the lemma, which, of course, is "use." Now, I need to evaluate the potential senses of the word. I see a few contenders:

*   **Sense 1:** "put into service; make work or employ for a particular purpose..." – this is about employing something to achieve an end, like tools or data. (Synonyms: utilize, apply, employ)
*   **Sense 2:** "take or consume (regularly or habitually)" - thinking of someone's consumption
*   **Sense 3:** "use up, consume fully" - thinking of full consumption
*   **Sense 4:** "seek or achieve an end by using to one's advantage" - thinking of self-benefit
*   **Sense 5:** "avail oneself to (practice, apply)" - think of practice or action
*   **Sense 6:** "habitually do something" - thinking of past actions

In this specific sentence, "calculated using the patient's height and weight" is the critical phrase. It's clear that the calculation *employs* the patient's height and weight as inputs. We're *utilizing* those measurements to perform a calculation. This context doesn't fit the habitual, consuming, or advantage-seeking senses.

Therefore, the best match is definitely **Sense 1**. The height and weight are being put into service or employed to achieve the purpose of calculating the body surface area. So, my conclusion is that the sense index for this instance of "using" should be 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patient
Context:
Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the <t>patient</t> s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
Okay, here's my interpretation of this medical context:

**Analyzing the Alimta Scenario**

Alright, I'm diving into this Alimta situation. Immediately, my mind zeroes in on the key elements: Alimta, cancer treatment, the significance of Body Surface Area (BSA), and the core process: calculating dosage based on a patient's height and weight. The immediate question is, "Who are we talking about here?"

Then, I consider the potential senses of the word 'patient'. The initial thought, sense 1, instantly clicks – we're dealing with *a person who requires medical care*. The second sense, referring to a semantic role, is relevant, but secondary for this specific calculation. The primary focus *has* to be the individual receiving the treatment. The process would be useless otherwise.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: height
Target surface form: height
Context:
Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s <t>height</t> and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes.

Candidate senses:
1. sense_key=height%1:07:00:: | definition=the vertical dimension of extension; distance from the base of something to the top | synonyms=tallness
2. sense_key=height%1:26:00:: | definition=the highest level or degree attainable; the highest stage of development | synonyms=acme, elevation, peak, pinnacle, summit, superlative | examples=his landscapes were deemed the acme of beauty; the artist's gifts are at their acme
3. sense_key=height%1:07:01:: | definition=(of a standing person) the distance from head to foot | synonyms=stature
4. sense_key=height%1:07:02:: | definition=elevation especially above sea level or above the earth's surface | synonyms=altitude | examples=the altitude gave her a headache

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{
  "sense_index": 3
}
```

content:
```json
{
  "sense_index": 3
}
```

reasoning_content:
**My Analysis of "Height" in Context**

Okay, the target word is "height," and the context is "calculated using the patient's height and weight." My mind immediately jumps to the possible senses, and I've got four candidates to consider. The first seems general: the *vertical dimension*. The second is about the *highest level or degree*. The third, ah, this one is interesting. It directly relates to *the distance from head to foot of a standing person*, which is also known as *stature*. And finally, there's the sense of *elevation above a surface*, like sea level or the Earth.

Considering the immediate context, "patient's height and weight," I can clearly rule out senses 1, 2, and 4. They just don't fit. The most precise and fitting definition is sense 3: *"the distance from head to foot of a standing person."* The synonym "stature" solidifies this connection. The context directly deals with *human* height for *clinical* calculation, so there's no ambiguity. Therefore, the most relevant sense here, and the best choice, is sense index 3.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: weight
Target surface form: weight
Context:
Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and <t>weight</t>). It is given once every three weeks as an intravenous infusion lasting 10 minutes.

Candidate senses:
1. sense_key=weight%1:07:00:: | definition=the vertical force exerted by a mass as a result of gravity
2. sense_key=weight%1:06:01:: | definition=sports equipment used in calisthenic exercises and weightlifting; it is not attached to anything and is raised and lowered by use of the hands and arms | synonyms=free weight, exercising weight
3. sense_key=weight%1:07:01:: | definition=the relative importance granted to something | synonyms=weightiness | examples=his opinion carries great weight; the progression implied an increasing weightiness of the items listed
4. sense_key=weight%1:06:00:: | definition=an artifact that is heavy
5. sense_key=weight%1:12:00:: | definition=an oppressive feeling of heavy force | examples=bowed down by the weight of responsibility
6. sense_key=weight%1:23:01:: | definition=a system of units used to express the weight of something | synonyms=system of weights
7. sense_key=weight%1:23:00:: | definition=a unit used to measure weight | synonyms=weight unit | examples=he placed two weights in the scale pan
8. sense_key=weight%1:23:02:: | definition=(statistics) a coefficient assigned to elements of a frequency distribution in order to represent their relative importance | synonyms=weighting

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Meaning of "Weight"**

Okay, let's break this down. The target word is "weight," and we're looking at it within the context of calculating body surface area using a patient's height and "weight." Clearly, we're dealing with a physical measurement here. So, let's consider the candidate senses.

Sense 1, "the vertical force exerted by a mass as a result of gravity," immediately resonates. It captures the essence of body weight – the gravitational force acting on the patient's mass, a quantifiable physical property. This is the definition we use in clinical settings, relating to measuring the mass of a patient.

The other senses are quickly eliminated: sports equipment (Sense 2) is irrelevant; importance (Sense 3), heavy artifacts (Sense 4), oppressive feelings (Sense 5), units for expressing/measuring weight (Senses 6, 7), or statistical coefficients (Sense 8) are all clearly off-target given the context of height and body surface area calculation.

Therefore, Sense 1 is the unambiguous winner. It's the only one that makes logical and practical sense within this specific medical context.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: give
Target surface form: given
Context:
Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is <t>given</t> once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta.

Candidate senses:
1. sense_key=give%2:40:03:: | definition=cause to have, in the abstract sense or physical sense | examples=She gave him a black eye; The draft gave me a cold
2. sense_key=give%2:40:05:: | definition=be the cause or source of | synonyms=yield, afford | examples=He gave me a lot of trouble; Our meeting afforded much interesting information
3. sense_key=give%2:40:00:: | definition=transfer possession of something concrete or abstract to somebody | examples=I gave her my money; can you give me lessons?
4. sense_key=give%2:40:07:: | definition=convey or reveal information | examples=Give one's name
5. sense_key=give%2:32:01:: | definition=convey, as of a compliment, regards, attention, etc.; bestow | synonyms=pay | examples=Don't pay him any mind; give the orders
6. sense_key=give%2:36:02:: | definition=organize or be responsible for | synonyms=hold, throw, have, make | examples=hold a reception; have, throw, or make a party
7. sense_key=give%2:32:00:: | definition=convey or communicate; of a smile, a look, a physical gesture | synonyms=throw | examples=Throw a glance; She gave me a dirty look
8. sense_key=give%2:40:01:: | definition=give as a present; make a gift of | synonyms=gift, present | examples=What will you give her for her birthday?
9. sense_key=give%2:36:03:: | definition=cause to happen or be responsible for | synonyms=yield | examples=His two singles gave the team the victory
10. sense_key=give%2:31:02:: | definition=dedicate | synonyms=pay, devote | examples=give thought to; give priority to
11. sense_key=give%2:36:00:: | definition=give or supply | synonyms=render, yield, return, generate | examples=The cow brings in 5 liters of milk; This year's crop yielded 1,000 bushels of corn
12. sense_key=give%2:40:09:: | definition=transmit (knowledge or skills) | synonyms=impart, leave, pass on | examples=give a secret to the Russians; leave your name and address here
13. sense_key=give%2:36:01:: | definition=bring about | synonyms=establish | examples=The trompe l'oeil-illusion establishes depth
14. sense_key=give%2:40:02:: | definition=leave with; give temporarily | examples=Can I give you my keys while I go in the pool?; Can I give you the children for the weekend?
15. sense_key=give%2:41:00:: | definition=emit or utter | examples=Give a gulp; give a yelp
16. sense_key=give%2:40:10:: | definition=endure the loss of | synonyms=sacrifice | examples=He gave his life for his children; I gave two sons to the war
17. sense_key=give%2:40:06:: | definition=place into the hands or custody of | synonyms=pass, hand, reach, pass on, turn over | examples=hand me the spoon, please; Turn the files over to me, please
18. sense_key=give%2:32:03:: | definition=give entirely to a specific person, activity, or cause | synonyms=dedicate, consecrate, commit, devote | examples=She committed herself to the work of God; give one's talents to a good cause
19. sense_key=give%2:40:13:: | definition=give (as medicine) | examples=I gave him the drug
20. sense_key=give%2:40:14:: | definition=give or convey physically | synonyms=apply | examples=She gave him First Aid; I gave him a punch in the nose
21. sense_key=give%2:32:02:: | definition=bestow | synonyms=render | examples=give homage; render thanks
22. sense_key=give%2:40:11:: | definition=bestow, especially officially | synonyms=grant | examples=grant a degree; give a divorce
23. sense_key=give%2:38:00:: | definition=move in order to make room for someone for something | synonyms=move over, give way, ease up, yield | examples=The park gave way to a supermarket; `Move over,' he told the crowd
24. sense_key=give%2:34:00:: | definition=give food to | synonyms=feed | examples=Feed the starving children in India; don't give the child this tough meat
25. sense_key=give%2:40:08:: | definition=contribute to some cause | synonyms=contribute, chip in, kick in | examples=I gave at the office
26. sense_key=give%2:38:13:: | definition=break down, literally or metaphorically | synonyms=collapse, fall in, cave in, give way, break, founder | examples=The wall collapsed; The business collapsed
27. sense_key=give%2:31:00:: | definition=estimate the duration or outcome of something | examples=He gave the patient three months to live; I gave him a very good chance at success
28. sense_key=give%2:41:10:: | definition=execute and deliver | examples=Give bond
29. sense_key=give%2:40:12:: | definition=deliver in exchange or recompense | examples=I'll give you three books for four CDs
30. sense_key=give%2:40:15:: | definition=afford access to | synonyms=afford, open | examples=the door opens to the patio; The French doors give onto a terrace
31. sense_key=give%2:36:13:: | definition=present to view | examples=He gave the sign to start
32. sense_key=give%2:36:12:: | definition=perform for an audience | examples=Pollini is giving another concert in New York
33. sense_key=give%2:35:00:: | definition=be flexible under stress of physical force | synonyms=yield | examples=This material doesn't give
34. sense_key=give%2:34:10:: | definition=propose | examples=He gave the first of many toasts at the birthday party
35. sense_key=give%2:32:11:: | definition=accord by verdict | examples=give a decision for the plaintiff
36. sense_key=give%2:32:08:: | definition=manifest or show | examples=This student gives promise of real creativity; The office gave evidence of tampering
37. sense_key=give%2:32:15:: | definition=offer in good faith | examples=He gave her his word
38. sense_key=give%2:32:14:: | definition=submit for consideration, judgment, or use | examples=give one's opinion; give an excuse
39. sense_key=give%2:32:09:: | definition=guide or direct, as by behavior of persuasion | examples=You gave me to think that you agreed with me
40. sense_key=give%2:32:07:: | definition=allow to have or take | examples=I give you two minutes to respond
41. sense_key=give%2:32:10:: | definition=inflict as a punishment | examples=She gave the boy a good spanking; The judge gave me 10 years
42. sense_key=give%2:30:13:: | definition=occur | examples=what gives?
43. sense_key=give%2:29:11:: | definition=consent to engage in sexual intercourse with a man | examples=She gave herself to many men
44. sense_key=give%2:29:10:: | definition=proffer (a body part) | examples=She gave her hand to her little sister

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
**Analyzing the Verb "Given" in a Medical Context**

Okay, so the task at hand is to pinpoint the most accurate sense of the word "given" within this sentence: "It is given once every three weeks as an intravenous infusion lasting 10 minutes." The "it" refers to Alimta, which, as we know, is a chemotherapy drug. The core of my analysis focuses on how "given" relates to administering medicine.

Let's dissect this. My initial instinct, based on the context, led me to candidate 19: sense\_key=give%2:40:13::. This sense is clearly defined as "give (as medicine)," and the example "I gave him the drug" feels like a perfect fit.

Just to be thorough, I'm checking other potential matches. Candidate 1 (cause to have...) and Candidate 3 (transfer possession...) don't seem like viable options. Candidate 20 (give or convey physically; apply) is closer, but even that is less precise.

Upon careful consideration of the context – Alimta, a drug, administered via intravenous infusion – candidate 19's specificity is key. The phrasing "give (as medicine)" perfectly captures the action. Therefore, I'm confident that sense key `give%2:40:13::` is the most appropriate interpretation here. It's the strongest match by far, given the medical nature of the sentence.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: once
Target surface form: once
Context:
Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given <t>once</t> every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta.

Candidate senses:
1. sense_key=once%4:02:00:: | definition=on one occasion | synonyms=one time, in one case | examples=once I ran into her
2. sense_key=once%4:02:02:: | definition=as soon as | examples=once we are home, we can rest
3. sense_key=once%4:02:01:: | definition=at a previous time | synonyms=formerly, at one time, erstwhile, erst | examples=at one time he loved her; her erstwhile writing

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Meaning of "Once" in a Medical Context**

Okay, so I'm presented with this medical text that describes a treatment being administered "<t>once</t> every three weeks." My initial task, as I see it, is to precisely define the meaning of "once" in this very specific context. This is crucial for accurate interpretation, especially when dealing with treatment schedules.

Immediately, I start to parse the possible senses of "once". I'm considering the potential ambiguity, and I'm listing out the likely interpretations. There are essentially three possibilities:

*   **Option 1:** "On one occasion." This would mean a single administration every three weeks – exactly what the text seems to be implying. This is the simplest and most direct interpretation of "once" in terms of frequency or occurrence.
*   **Option 2:** "As soon as." This sense of "once" creates a temporal relationship, implying a subsequent event. This doesn't make sense in this context. It would imply that the infusion starts as soon as every three weeks, which makes no sense.
*   **Option 3:** "At a previous time." This refers to a past situation, or "formerly". This has no relevance here, as the treatment occurs on a repeating basis.

So, after a rapid semantic analysis of those senses, I can immediately dismiss senses two and three as nonsensical in this medical description. They just don't fit. The only interpretation that logically aligns with the text's description of an intravenous infusion is sense one: "on one occasion." Therefore, the treatment is given once every three weeks.

The word "once" here indicates a frequency of administration. It means that the patient is given the intravenous infusion a single time during each three-week cycle. The text is very clear, and this interpretation is unambiguous.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: every
Target surface form: every
Context:
Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once <t>every</t> three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta.

Candidate senses:
1. sense_key=every%5:00:00:all:00 | definition=(used of count nouns) each and all of the members of a group considered singly and without exception | examples=every person is mortal; every party is welcome
2. sense_key=every%5:00:02:all:00 | definition=each and all of a series of entities or intervals as specified | examples=every third seat; every two hours

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

content:
```json
{"sense_index": 2}
```

reasoning_content:
**Analyzing the Best Sense for "Every"**

Okay, so I need to nail down the most accurate sense of "every" in this sentence: "It is given once <t>every</t> three weeks as an intravenous infusion lasting 10 minutes." Let's see... the system's provided two candidates:

*   Sense 1: "each and all of the members of a group considered singly and without exception" – seems a little broad, like "every person is mortal." Doesn't quite fit the rhythmic, time-based feel of the context.
*   Sense 2: "each and all of a series of entities or intervals as specified" – Ah, bingo! This is it. "Every three weeks" clearly refers to a recurring interval, just like "every two hours" or "every third seat." The context is all about this periodic schedule. That's a perfect match. Sense 2 it is. Case closed.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: week
Target surface form: weeks
Context:
Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three <t>weeks</t> as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta.

Candidate senses:
1. sense_key=week%1:28:00:: | definition=any period of seven consecutive days | synonyms=hebdomad | examples=it rained for a week
2. sense_key=week%1:28:01:: | definition=hours or days of work in a calendar week | synonyms=workweek | examples=they worked a 40-hour week
3. sense_key=week%1:28:02:: | definition=a period of seven consecutive days starting on Sunday | synonyms=calendar week

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Temporal Meaning of "Weeks"**

Okay, so I need to nail down the precise meaning of "weeks" in this clinical context: "It is given once every three weeks as an intravenous infusion lasting 10 minutes." My initial approach is to consider the possible semantic senses. Let's see... I've got a few options here. First, there's the standard definition: a period of seven consecutive days, which is often referred to as a "hebdomad," like "it rained for a week." Then, there’s the sense related to the workweek. Finally, there's the specific calendar week starting on Sunday.

Given the phrase "once every three weeks," it's pretty clear the time period definition is what's relevant. The context suggests a duration, a temporal interval. This isn't about work hours or the specific start day of a calendar week. So, that leaves me with the first option, the "any period of seven consecutive days" sense. This aligns perfectly with the idea of a treatment administered at regular intervals. It's a clear and concise interpretation of what's intended. Therefore, sense 1 is, without a doubt, the correct interpretation. I'm confident in selecting "week%1:28:00::" as the correct sense.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: infusion
Target surface form: infusion
Context:
Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous <t>infusion</t> lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta.

Candidate senses:
1. sense_key=infusion%1:27:00:: | definition=a solution obtained by steeping or soaking a substance (usually in water) | synonyms=extract
2. sense_key=infusion%1:22:00:: | definition=the process of extracting certain active properties (as a drug from a plant) by steeping or soaking (usually in water)
3. sense_key=infusion%1:04:00:: | definition=(medicine) the passive introduction of a substance (a fluid or drug or electrolyte) into a vein or between tissues (as by gravitational force)
4. sense_key=infusion%1:04:01:: | definition=the act of infusing or introducing a certain modifying element or quality | examples=the team's continued success is attributable to a steady infusion of new talent

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 3}
```

content:
```json
{"sense_index": 3}
```

reasoning_content:
Here's my thought process on this:

**Deconstructing "Infusion" in a Medical Context**

Okay, the target word is "infusion", and the phrase "intravenous infusion lasting 10 minutes" is pretty clear-cut medical language. I've got to determine the correct sense of "infusion" here, given the context.

I immediately start by considering the different senses of the word. Sense 1 is about steeping or soaking, like making tea. Sense 2 expands on that process, focusing on extracting active properties, particularly from plants. Sense 3 is the medical definition; the passive introduction of a substance into a vein. Finally, Sense 4 is more abstract, talking about introducing a modifying element.

With "intravenous" and a 10-minute duration, it's immediately obvious that Sense 3 is the correct meaning here. The context is explicitly medical, pointing towards the administration of a fluid or drug directly into the bloodstream. The timeframe also supports that this is a direct, probably controlled, procedure.

So, the sense index is 3. Got it.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: last
Target surface form: lasting
Context:
Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion <t>lasting</t> 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta.

Candidate senses:
1. sense_key=last%2:42:00:: | definition=persist for a specified period of time | synonyms=endure | examples=The bad weather lasted for three days
2. sense_key=last%2:42:01:: | definition=continue to live through hardship or adversity | synonyms=survive, live, live on, go, endure, hold up | examples=We went without water and food for 3 days; These superstitions survive in the backwaters of America

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Target Word "Lasting"**

Okay, so the task is to pinpoint the correct sense of "lasting" in this sentence: "It is given once every three weeks as an intravenous infusion lasting 10 minutes." Let's break it down.

My initial scan brings up two potential senses from the lexicon: "persist for a specified period of time" and "continue to live through hardship or adversity". Clearly, the first definition, associated with the sense key last%2:42:00::, is the one we want. The phrase "lasting 10 minutes" is all about the infusion's *duration*, its persistence over a specific timeframe. Sense 2, pertaining to survival or enduring hardship (last%2:42:01::), is completely out of context here. It's a straightforward case of semantic disambiguation. The infusion *lasts* for 10 minutes – it endures, it persists, that's the core meaning being conveyed. The other senses are irrelevant for this application.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: minute
Target surface form: minutes
Context:
Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 <t>minutes</t>. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta.

Candidate senses:
1. sense_key=minute%1:28:00:: | definition=a unit of time equal to 60 seconds or 1/60th of an hour | synonyms=min | examples=he ran a 4 minute mile
2. sense_key=minute%1:28:01:: | definition=an indefinitely short time | synonyms=moment, mo, second, bit | examples=wait just a moment; in a mo
3. sense_key=minute%1:28:02:: | definition=a particular point in time | synonyms=moment, second, instant | examples=the moment he arrived the party began
4. sense_key=minute%1:23:00:: | definition=a unit of angular distance equal to a 60th of a degree | synonyms=arcminute, minute of arc
5. sense_key=minute%1:10:00:: | definition=a short note | examples=the secretary keeps the minutes of the meeting
6. sense_key=minute%1:07:00:: | definition=distance measured by the time taken to cover it | synonyms=hour | examples=we live an hour from the airport; its just 10 minutes away

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Word "Minutes"**

Okay, let's break this down. My goal is to pinpoint the exact meaning of "minutes" within this phrase: "...lasting 10 <t>minutes</t>." I'm presented with a few candidate senses, and it's my job to select the most appropriate one.

I've got six possibilities, each with its own definition and sense key. We have a unit of time (sense 1), a short time (sense 2), a point in time (sense 3), an angular measurement (sense 4), a short note (sense 5), and a distance (sense 6).

Now, considering the phrase "lasting 10 minutes," the most logical interpretation is that "minutes" refers to a duration of time. It's quantifying how long something endures. A specific, definable block of time. Sense 1, "a unit of time equal to 60 seconds or 1/60th of an hour," fits this context perfectly. Therefore, the correct sense index is 1. Done.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: reduce
Target surface form: reduce
Context:
The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To <t>reduce</t> side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose.

Candidate senses:
1. sense_key=reduce%2:30:00:: | definition=cut down on; make a reduction in | synonyms=cut down, cut back, trim, trim down, trim back, cut | examples=reduce your daily fat intake; The employer wants to cut back health benefits
2. sense_key=reduce%2:30:06:: | definition=make less complex | examples=reduce a problem to a single question
3. sense_key=reduce%2:41:00:: | definition=bring to humbler or weaker state or condition | examples=He reduced the population to slavery
4. sense_key=reduce%2:40:04:: | definition=simplify the form of a mathematical equation of expression by substituting one term for another
5. sense_key=reduce%2:37:00:: | definition=lower in grade or rank or force somebody into an undignified situation | examples=She reduced her niece to a servant
6. sense_key=reduce%2:30:11:: | definition=be the essential element | synonyms=come down, boil down | examples=The proposal boils down to a compromise
7. sense_key=reduce%2:30:05:: | definition=reduce in size; reduce physically | synonyms=shrink | examples=Hot water will shrink the sweater; Can you shrink this image?
8. sense_key=reduce%2:40:00:: | definition=lessen and make more modest | examples=reduce one's standard of living
9. sense_key=reduce%2:30:04:: | definition=make smaller | synonyms=scale down | examples=reduce an image
10. sense_key=reduce%2:30:03:: | definition=to remove oxygen from a compound, or cause to react with hydrogen or form a hydride, or to undergo an increase in the number of electrons | synonyms=deoxidize, deoxidise
11. sense_key=reduce%2:30:01:: | definition=narrow or limit | synonyms=tighten | examples=reduce the influx of foreigners
12. sense_key=reduce%2:41:03:: | definition=put down by force or intimidation | synonyms=repress, quash, keep down, subdue, subjugate | examples=The government quashes any attempt of an uprising; China keeps down her dissidents very efficiently
13. sense_key=reduce%2:35:00:: | definition=undergo meiosis | examples=The cells reduce
14. sense_key=reduce%2:35:01:: | definition=reposition (a broken bone after surgery) back to its normal site
15. sense_key=reduce%2:30:12:: | definition=destress and thus weaken a sound when pronouncing it
16. sense_key=reduce%2:30:08:: | definition=reduce in scope while retaining essential elements | synonyms=abridge, foreshorten, abbreviate, shorten, cut, contract | examples=The manuscript must be shortened
17. sense_key=reduce%2:30:10:: | definition=be cooked until very little liquid is left | synonyms=boil down, decoct, concentrate | examples=The sauce should reduce to one cup
18. sense_key=reduce%2:30:02:: | definition=cook until very little liquid is left | synonyms=boil down, concentrate | examples=The cook reduced the sauce by boiling it for a long time
19. sense_key=reduce%2:30:09:: | definition=lessen the strength or flavor of a solution or mixture | synonyms=dilute, thin, thin out, cut | examples=cut bourbon
20. sense_key=reduce%2:29:00:: | definition=take off weight | synonyms=melt off, lose weight, slim, slenderize, thin, slim down

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Semantic Landscape of "Reduce"**

Alright, let's break this down. The task is to pin down the most accurate WordNet sense of "reduce" within the phrase "To reduce side effects...". Given my expertise, I'm already mentally sifting through potential interpretations.

I've got a list of candidate senses, and I need to assess their relevance. My initial thought is to quickly consider each sense's definition, weighing them against the context of "reducing side effects."

First, sense 1, "cut down on; make a reduction in," immediately grabs my attention. The synonyms ("cut down," "cut back," etc.) and examples ("reduce your daily fat intake") align perfectly with the concept of decreasing or lessening something, which seems very plausible for side effects. It's a reduction in their severity or frequency.

I also see sense 9, "make smaller," and sense 8, "lessen and make more modest". Sense 11 "narrow or limit; tighten" is another option. However, these are less of a direct match with the idea of diminishing or alleviating the impact of side effects.

Therefore, when weighing these options, sense 1 stands out as the most appropriate interpretation. The definition of "cut down on; make a reduction in" perfectly captures the intention of diminishing the impact or severity of side effects. It's the most semantically sound choice in this particular context.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: side_effect
Target surface form: side effects
Context:
The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce <t>side effects</t>, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose.

Candidate senses:
1. sense_key=side_effect%1:26:00:: | definition=a secondary and usually adverse effect of a drug or therapy | examples=severe headaches are one of the side effects of the drug
2. sense_key=side_effect%1:19:00:: | definition=any adverse and unwanted secondary effect | synonyms=fallout | examples=a strategy to contain the fallout from the accounting scandal

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing "Side Effects" in Context**

Okay, here's the situation: the target word is "side effects," which is the plural form of "side_effect." The sentence I'm given mentions "To reduce side effects, patients should take a corticosteroid and folic acid... during treatment with Alimta." Alright, "Alimta" along with "corticosteroid" and the context of treatment clearly point to medication or chemotherapy. My expertise kicks in – I instantly recognize this as a medical context.

Now, I need to choose the correct sense. I've got two to consider. The first, sense key "side_effect%1:26:00::", defines a "secondary and usually adverse effect of a drug or therapy." Bingo! This hits the nail on the head. The second, "side_effect%1:19:00::", is a more general "any adverse and unwanted secondary effect," essentially meaning "fallout." While that's *possible* in some abstract contexts, the phrasing here screams medical, and the provided examples fit the medical definition perfectly. Therefore, I'm confident that sense 1, the definition specifically referring to a drug or therapy, is the intended meaning.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, <t>patients</t> should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
Okay, here's my interpretation of that thought process, tailored for an expert audience:

**Analyzing the Target Word "Patients"**

Alright, the task is to disambiguate "patients" in the context "To reduce side effects, patients should take a corticosteroid and folic acid...". Immediately, I consider the likely senses. It's almost always *sense 1*, the classic medical definition – a person receiving care. But I know I must be precise, so I keep in mind the potential for *sense 2*, which is a more abstract, semantic role – the affected entity. Given the context of medical treatment, it’s a pretty straightforward case. The sentence is about medical treatment so the word must mean people receiving care. I can confidently assign "patient%1:18:00::" to *sense 1*, and therefore my disambiguated sense index is 1. That's a solid, unambiguous assignment.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: type
Target surface form: type
Context:
The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a <t>type</t> of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose.

Candidate senses:
1. sense_key=type%1:09:00:: | definition=a subdivision of a particular kind of thing | examples=what type of sculpture do you prefer?
2. sense_key=type%1:18:00:: | definition=a person of a specified kind (usually with many eccentricities) | synonyms=character, eccentric, case | examples=a real character; a strange character
3. sense_key=type%1:14:01:: | definition=(biology) the taxonomic group whose characteristics are used to define the next higher taxon
4. sense_key=type%1:10:01:: | definition=printed characters | examples=small type is hard to read
5. sense_key=type%1:10:00:: | definition=all of the tokens of the same symbol | examples=the word `element' contains five different types of character
6. sense_key=type%1:06:00:: | definition=a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper | examples=he dropped a case of type, so they made him pick them up

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**My Analysis of "Type" in Context**

Okay, let's break this down. The objective is to identify the most accurate sense of "type" in this clinical context: "...patients should take a corticosteroid and folic acid (a <t>type</t> of vitamin), and receive injections of vitamin B12...". Clearly, "type" here is functioning as a descriptor, linking folic acid to a broader category: "vitamin". My immediate thought is to consider the various dictionary senses provided and filter based on that relationship.

Looking at the candidate senses, I can quickly eliminate a few. "Person of a specified kind" (sense 2), "taxonomic group" (sense 3), and anything related to "printed characters" (senses 4, 5, and 6) are all irrelevant. The context of vitamin usage is not about character sets or taxonomy.

That leaves me with sense 1: "a subdivision of a particular kind of thing." This seems promising, it is most closely related to the context: folic acid being a *subdivision* of the *kind* of thing being described as a vitamin.

Therefore, sense 1 is indeed the appropriate sense for this usage of "type." Thus, the sense index is 1. I'm satisfied.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: injection
Target surface form: injections
Context:
The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive <t>injections</t> of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose.

Candidate senses:
1. sense_key=injection%1:04:00:: | definition=the forceful insertion of a substance under pressure
2. sense_key=injection%1:27:00:: | definition=any solution that is injected (as into the skin) | synonyms=injectant
3. sense_key=injection%1:04:01:: | definition=the act of putting a liquid into the body by means of a syringe | synonyms=shot | examples=the nurse gave him a flu shot

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 3}
```

reasoning_content:
**Analyzing the Meaning of "Injections"**

Okay, so I'm looking at the word "injections" in the sentence "…and receive injections of vitamin B12 during treatment with Alimta." My immediate task is to pinpoint the correct sense of "injection" here. Let's see, the system presents me with a few candidates:

*   **injection%1:04:00::** This is the forceful insertion of a substance under pressure. Definitely not this one; too generic. Think fuel injection.
*   **injection%1:27:00::** This is the solution itself, the injectant. It *could* work, but it feels a bit... passive in this context. While one *could* "receive injections of vitamin B12" and technically be referring to the substance, something feels off.
*   **injection%1:04:01::** Aha, this one's more promising! It's the act of putting a liquid into the body, the procedure itself – basically a shot. That's the key: "The act of putting a liquid into the body by means of a syringe". And the synonyms are spot on: "shot"! Now we're talking.

Given the context, "receive injections of vitamin B12," it seems far more likely the intent is to say patients are receiving the *procedure* – the shots – rather than just the substance (the injectant) passively. One *receives* the *act* of "putting a liquid into the body".

I can confirm my instinct by thinking of how people commonly discuss this. We would say things like, "They receive shots of vitamin B12," which perfectly maps to the chosen sense. We wouldn't typically say they "received injectant of vitamin B12".

Therefore, the intended meaning is definitely sense 3: "the act of putting a liquid into the body by means of a syringe". The system's index is correct.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: treatment
Target surface form: treatment
Context:
The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during <t>treatment</t> with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose.

Candidate senses:
1. sense_key=treatment%1:04:00:: | definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) | synonyms=intervention
2. sense_key=treatment%1:04:01:: | definition=the management of someone or something | synonyms=handling | examples=the handling of prisoners; the treatment of water sewage
3. sense_key=treatment%1:07:00:: | definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture
4. sense_key=treatment%1:10:00:: | definition=an extended communication (often interactive) dealing with some particular topic | synonyms=discussion, discourse | examples=the book contains an excellent discussion of modal logic; his treatment of the race question is badly biased

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**My Analysis of "Treatment" in Context**

Okay, so the task is to pinpoint the most accurate meaning of "treatment" in the phrase "...and receive injections of vitamin B12 during treatment with Alimta." I immediately start by considering the potential senses. I've got the following options:

1.  "care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)" - This feels like the most obvious candidate, given the medical context.
2.  "the management of someone or something" - This could potentially apply, but feels less precise than the first option in this scenario.
3.  "a manner of dealing with something artistically" - Definitely not relevant; we're dealing with a pharmaceutical context, not an artistic one.
4.  "an extended communication (often interactive) dealing with some particular topic" - No, this is also inapplicable; the context is clearly not about communication.

Given that Alimta is an anticancer chemotherapy drug, the first sense, describing medical care and procedures to relieve illness or injury, is the clear winner. Therefore, I'm confident in selecting that sense. This is a straightforward application of domain knowledge to disambiguate the word.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: give
Target surface form: given
Context:
How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is <t>given</t> with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects.

Candidate senses:
1. sense_key=give%2:40:03:: | definition=cause to have, in the abstract sense or physical sense | examples=She gave him a black eye; The draft gave me a cold
2. sense_key=give%2:40:05:: | definition=be the cause or source of | synonyms=yield, afford | examples=He gave me a lot of trouble; Our meeting afforded much interesting information
3. sense_key=give%2:40:00:: | definition=transfer possession of something concrete or abstract to somebody | examples=I gave her my money; can you give me lessons?
4. sense_key=give%2:40:07:: | definition=convey or reveal information | examples=Give one's name
5. sense_key=give%2:32:01:: | definition=convey, as of a compliment, regards, attention, etc.; bestow | synonyms=pay | examples=Don't pay him any mind; give the orders
6. sense_key=give%2:36:02:: | definition=organize or be responsible for | synonyms=hold, throw, have, make | examples=hold a reception; have, throw, or make a party
7. sense_key=give%2:32:00:: | definition=convey or communicate; of a smile, a look, a physical gesture | synonyms=throw | examples=Throw a glance; She gave me a dirty look
8. sense_key=give%2:40:01:: | definition=give as a present; make a gift of | synonyms=gift, present | examples=What will you give her for her birthday?
9. sense_key=give%2:36:03:: | definition=cause to happen or be responsible for | synonyms=yield | examples=His two singles gave the team the victory
10. sense_key=give%2:31:02:: | definition=dedicate | synonyms=pay, devote | examples=give thought to; give priority to
11. sense_key=give%2:36:00:: | definition=give or supply | synonyms=render, yield, return, generate | examples=The cow brings in 5 liters of milk; This year's crop yielded 1,000 bushels of corn
12. sense_key=give%2:40:09:: | definition=transmit (knowledge or skills) | synonyms=impart, leave, pass on | examples=give a secret to the Russians; leave your name and address here
13. sense_key=give%2:36:01:: | definition=bring about | synonyms=establish | examples=The trompe l'oeil-illusion establishes depth
14. sense_key=give%2:40:02:: | definition=leave with; give temporarily | examples=Can I give you my keys while I go in the pool?; Can I give you the children for the weekend?
15. sense_key=give%2:41:00:: | definition=emit or utter | examples=Give a gulp; give a yelp
16. sense_key=give%2:40:10:: | definition=endure the loss of | synonyms=sacrifice | examples=He gave his life for his children; I gave two sons to the war
17. sense_key=give%2:40:06:: | definition=place into the hands or custody of | synonyms=pass, hand, reach, pass on, turn over | examples=hand me the spoon, please; Turn the files over to me, please
18. sense_key=give%2:32:03:: | definition=give entirely to a specific person, activity, or cause | synonyms=dedicate, consecrate, commit, devote | examples=She committed herself to the work of God; give one's talents to a good cause
19. sense_key=give%2:40:13:: | definition=give (as medicine) | examples=I gave him the drug
20. sense_key=give%2:40:14:: | definition=give or convey physically | synonyms=apply | examples=She gave him First Aid; I gave him a punch in the nose
21. sense_key=give%2:32:02:: | definition=bestow | synonyms=render | examples=give homage; render thanks
22. sense_key=give%2:40:11:: | definition=bestow, especially officially | synonyms=grant | examples=grant a degree; give a divorce
23. sense_key=give%2:38:00:: | definition=move in order to make room for someone for something | synonyms=move over, give way, ease up, yield | examples=The park gave way to a supermarket; `Move over,' he told the crowd
24. sense_key=give%2:34:00:: | definition=give food to | synonyms=feed | examples=Feed the starving children in India; don't give the child this tough meat
25. sense_key=give%2:40:08:: | definition=contribute to some cause | synonyms=contribute, chip in, kick in | examples=I gave at the office
26. sense_key=give%2:38:13:: | definition=break down, literally or metaphorically | synonyms=collapse, fall in, cave in, give way, break, founder | examples=The wall collapsed; The business collapsed
27. sense_key=give%2:31:00:: | definition=estimate the duration or outcome of something | examples=He gave the patient three months to live; I gave him a very good chance at success
28. sense_key=give%2:41:10:: | definition=execute and deliver | examples=Give bond
29. sense_key=give%2:40:12:: | definition=deliver in exchange or recompense | examples=I'll give you three books for four CDs
30. sense_key=give%2:40:15:: | definition=afford access to | synonyms=afford, open | examples=the door opens to the patio; The French doors give onto a terrace
31. sense_key=give%2:36:13:: | definition=present to view | examples=He gave the sign to start
32. sense_key=give%2:36:12:: | definition=perform for an audience | examples=Pollini is giving another concert in New York
33. sense_key=give%2:35:00:: | definition=be flexible under stress of physical force | synonyms=yield | examples=This material doesn't give
34. sense_key=give%2:34:10:: | definition=propose | examples=He gave the first of many toasts at the birthday party
35. sense_key=give%2:32:11:: | definition=accord by verdict | examples=give a decision for the plaintiff
36. sense_key=give%2:32:08:: | definition=manifest or show | examples=This student gives promise of real creativity; The office gave evidence of tampering
37. sense_key=give%2:32:15:: | definition=offer in good faith | examples=He gave her his word
38. sense_key=give%2:32:14:: | definition=submit for consideration, judgment, or use | examples=give one's opinion; give an excuse
39. sense_key=give%2:32:09:: | definition=guide or direct, as by behavior of persuasion | examples=You gave me to think that you agreed with me
40. sense_key=give%2:32:07:: | definition=allow to have or take | examples=I give you two minutes to respond
41. sense_key=give%2:32:10:: | definition=inflict as a punishment | examples=She gave the boy a good spanking; The judge gave me 10 years
42. sense_key=give%2:30:13:: | definition=occur | examples=what gives?
43. sense_key=give%2:29:11:: | definition=consent to engage in sexual intercourse with a man | examples=She gave herself to many men
44. sense_key=give%2:29:10:: | definition=proffer (a body part) | examples=She gave her hand to her little sister

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 19}
```

content:
```json
{"sense_index": 19}
```

reasoning_content:
**Analyzing the Verb "Given" in a Medical Context**

Okay, the target word is "given" in that Alimta sentence. My initial thought is to zero in on the specific sense of "give" because its meaning can be quite varied. I know Alimta is a medication – an anticancer chemotherapy, specifically – and it's being administered to a patient.

So, let's analyze the relevant senses. I'm seeing "give (as medicine)" – that's sense 19 – as the prime candidate. Looking closer at the definitions in the WordNet database and examples really seems to confirm it. The example "I gave him the drug" is a perfect fit.

Just to be thorough, I'm quickly eliminating other senses like a general transfer of possession or causing something to exist. The context here is very specific to medical administration: the sentence is specifically discussing the process of administering or providing medication: "an anti-emetic medicine...should also be given."

Therefore, I'm confident that sense index 19 is the correct interpretation.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic <t>medicine</t> (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects.

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
**My Analysis of "Medicine" in Context**

Okay, so the task is to pinpoint the specific meaning of "medicine" in this phrase: "...an anti-emetic <t>medicine</t> (to prevent vomiting) and fluids..." Let's see... I've got a few candidate senses to consider. The first one, "medical specialty," doesn't seem to fit. An anti-emetic isn't a *branch* of medical science itself, that’s clearly incorrect. The fourth, referring to punishment, is obviously a distractor; I'm assuming that's there to test disambiguation. So that leaves senses two and three. Sense three, "the learned profession... devoted to preventing or alleviating... diseases..." focuses on the *practice* of medicine. While that's *related*, it doesn't quite capture the *thing* being described by "anti-emetic."

Ah, here we go! Sense two jumps out immediately. It defines "medicine" as "something that treats or prevents or alleviates the symptoms of disease." That's perfect. An anti-emetic *is* a medication, a drug, a medicament, designed to *prevent* vomiting. It’s the "something" that treats this symptom. Therefore, the best sense is unquestionably sense index 2. This is a straightforward application of lexical semantics.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: prevent
Target surface form: prevent
Context:
How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to <t>prevent</t> vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects.

Candidate senses:
1. sense_key=prevent%2:41:01:: | definition=keep from happening or arising; make impossible | synonyms=forestall, foreclose, preclude, forbid | examples=My sense of tact forbids an honest answer; Your role in the projects precludes your involvement in the competitive project
2. sense_key=prevent%2:41:00:: | definition=stop (someone or something) from doing something or being in a certain state | synonyms=keep | examples=We must prevent the cancer from spreading; His snoring kept me from falling asleep

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**My Analysis of "Prevent" in Context**

Okay, so I need to nail down the correct sense of "prevent" in this specific sentence: "When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose." My goal is to choose the most accurate sense index.

I'm given two candidate senses:

*   **Sense 1:** "keep from happening or arising; make impossible" (synonyms: forestall, preclude).
*   **Sense 2:** "stop (someone or something) from doing something or being in a certain state" (synonyms: keep).

I'm immediately looking at the syntactic frame and the meaning. In Sense 1, the definition, "keep from happening or arising," seems to fit directly with "to prevent vomiting" and "to prevent dehydration." I interpret this as "to keep vomiting from happening/arising." Vomiting and dehydration are actions/events, so it's a matter of preventing their occurrence.

In contrast, Sense 2 implies stopping *someone or something* from *doing* something or being in a state. The syntax often involves an object and a prepositional phrase, such as "prevent someone from V-ing." Examples of this would be "prevent the cancer from spreading" or "His snoring kept me from falling asleep." Here, the focus is on a patient or agent. Sense 1's use has a different syntactic pattern: the object is the event itself.

I'm now cross-referencing this with the WordNet entries. Let's see...

*   **prevent%2:41:01:: (Sense 1)** has the definition: "keep from happening or arising; make impossible" and the frame: "Somebody ----s something; Something ----s something".
*   **prevent%2:41:00:: (Sense 2)** has the definition: "stop (someone or something) from doing something or being in a certain state" and frames: "Somebody ----s somebody from V-ing; Something ----s somebody from V-ing; Somebody ----s something from V-ing; etc."

In the given sentence, I'm observing "(to prevent vomiting)". "Vomiting" acts as a noun (and an event) functioning as the direct object. Therefore, the situation is that "Something prevents vomiting," which means keeping it from happening or arising. I'm certain that Sense 1 is the appropriate and accurate sense.