[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: part
Target surface form: parts
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other <t>parts</t> of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=part%1:24:00:: | definition=something determined in relation to something that includes it | synonyms=portion, component part, component, constituent | examples=he wanted to feel a part of something bigger than himself; I read a portion of the manuscript
2. sense_key=part%1:06:00:: | definition=something less than the whole of a human artifact | synonyms=portion | examples=the rear part of the house; glue the two parts together
3. sense_key=part%1:17:00:: | definition=a portion of a natural object | synonyms=piece | examples=they analyzed the river into three parts; he needed a piece of granite
4. sense_key=part%1:09:02:: | definition=that which concerns a person with regard to a particular role or situation | examples=it requires vigilance on our part; they resisted every effort on his part
5. sense_key=part%1:15:00:: | definition=the extended spatial location of something | synonyms=region | examples=the farming regions of France; religions in all parts of the world
6. sense_key=part%1:04:01:: | definition=the actions and activities assigned to or required or expected of a person or group | synonyms=function, office, role | examples=the function of a teacher; the government must do its part
7. sense_key=part%1:09:01:: | definition=an actor's portrayal of someone in a play | synonyms=character, role, theatrical role, persona | examples=she played the part of Desdemona
8. sense_key=part%1:21:00:: | definition=assets belonging to or due to or contributed by an individual person or group | synonyms=share, portion, percentage | examples=he wanted his share in cash
9. sense_key=part%1:09:00:: | definition=one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division | examples=the written part of the exam; the finance section of the company
10. sense_key=part%1:08:01:: | definition=a line of scalp that can be seen when sections of hair are combed in opposite directions | synonyms=parting | examples=his part was right in the middle
11. sense_key=part%1:10:00:: | definition=the melody carried by a particular voice or instrument in polyphonic music | synonyms=voice | examples=he tried to sing the tenor part
12. sense_key=part%1:04:03:: | definition=the part played by a person in bringing about a result | synonyms=contribution, share | examples=I am proud of my contribution in advancing the project; they all did their share of the work

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Disambiguating "parts" in a Medical Context**

Okay, here's the breakdown. My task is to figure out the right WordNet sense of "parts" in that phrase about cancer spreading. It needs to be precise, especially given the technical context. I'm going through the senses one by one, methodically, focusing on how well each fits the meaning.

The prime contenders seemed to be: Sense 1, the general "something determined in relation to something that includes it," Sense 3, "a portion of a natural object," and Sense 5, "the extended spatial location of something." Sense 1 seems the most likely, considering that Sense 1 is the part-whole relation.

I'm thinking like the annotators for SemEval-2013 Task 12, who had to disambiguate the word in the context of medical texts (EMEA corpus).

Sense 5 ("region") is tempting because cancer *does* spread to regions, but the core meaning of "parts of the body" is anatomical components. Sense 3 (“a portion of a natural object”), is less appropriate because "piece" is its synonym, which doesn't really work here. This is important to note - word senses are defined through synonyms that can be swapped. Thus, I would not say "pieces of the body".

The phrase "component part" is synonymous with Sense 1, which means this sense is the most accurate. I'm confident in tagging it as `part%1:24:00::` because it best reflects "component" or "constituent" sense of "part" in the context of the body. My final output is {"sense_index": 1}.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: body
Target surface form: body
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the <t>body</t>), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=body%1:08:00:: | definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
2. sense_key=body%1:14:00:: | definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium; the student body
3. sense_key=body%1:08:02:: | definition=a natural object consisting of a dead animal or person | synonyms=dead body | examples=they found the body in the lake
4. sense_key=body%1:17:00:: | definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. sense_key=body%1:08:01:: | definition=the body excluding the head and neck and limbs | synonyms=torso, trunk | examples=they moved their arms and legs and bodies
6. sense_key=body%1:14:02:: | definition=a collection of particulars considered as a system | examples=a body of law; a body of doctrine
7. sense_key=body%1:07:00:: | definition=the property of holding together and retaining its shape | synonyms=consistency, consistence, eubstance | examples=wool has more body than rayon; when the dough has enough consistency it is ready to bake
8. sense_key=body%1:10:00:: | definition=the central message of a communication | examples=the body of the message was short
9. sense_key=body%1:07:01:: | definition=the main mass of a thing
10. sense_key=body%1:06:01:: | definition=a resonating chamber in a musical instrument (as the body of a violin) | synonyms=soundbox
11. sense_key=body%1:06:00:: | definition=the external structure of a vehicle | examples=the body of the car was badly rusted

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

finish_reason: stop

content:
```json
{"sense_index": 1}
```

role: assistant

reasoning_content:
**Analyzing the "Body" in This Medical Context**

Okay, let's break this down. My goal is to pinpoint the most accurate meaning of "body" within this clinical context: "...and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy..."

My expertise tells me that precision is paramount here. I've been given a list of potential senses for "body," and I need to methodically evaluate each one:

*   **Sense 1 (body%1:08:00::):** "the entire structure of an organism (an animal, plant, or human being) (organic structure, physical structure)" - This is the primary contender, aligning with my initial instinct. It encompasses the entirety of the human form, which is clearly relevant in this medical scenario.
*   **Sense 2 (body%1:14:00::):** "a group of persons associated by some common tie or occupation and regarded as an entity" - This seems completely irrelevant; we aren't talking about a committee or group.
*   **Sense 3 (body%1:08:02::):** "a natural object consisting of a dead animal or person (dead body)" - This is nonsensical in this medical context. The patient is living.
*   **Sense 4 (body%1:17:00::):** "an individual 3-dimensional object that has mass and that is distinguishable from other objects" - Too generic. While technically true of a human, it lacks the necessary specificity.
*   **Sense 5 (body%1:08:01::):** "the body excluding the head and neck and limbs (torso, trunk)" - This is too limited. The phrase "other parts of the body" implies a much broader scope, including limbs, head, internal organs, etc.
*   **Sense 6 (body%1:14:02::):** "a collection of particulars considered as a system" - Abstract and doesn't fit the context.
*   **Sense 7 (body%1:07:00::):** "the property of holding together and retaining its shape" - Physical, but overly general. Not relevant here.
*   **Sense 8 (body%1:10:00::):** "the central message of a communication" - Clearly not relevant.
*   **Sense 9 (body%1:07:01::):** "the main mass of a thing" - Too vague. This could apply to anything.
*   **Sense 10 (body%1:06:01::):** "a resonating chamber in a musical instrument" - Clearly irrelevant.
*   **Sense 11 (body%1:06:00::):** "the external structure of a vehicle" - Not applicable.

Given the phrase "spread easily, to other parts of the body", I'm now certain that **Sense 1 (body%1:08:00::) is the correct interpretation**. It refers to the *entire* human physical structure—the organism as a whole—which is the only reasonable way to interpret this medical context. The malignancy is spreading within the patient, which is within that person's physical body.

type: thinking

service_tier: default

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in <t>patients</t> who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
Okay, here's my interpretation of that thought process, tailored for an expert audience:

**Analyzing "Patients" in Context**

Alright, the word in question is "patients," the plural of "patient." The surrounding context is "...in patients who have not received chemotherapy..." My first instinct, as always, is to disambiguate. I immediately pull up the possible senses, which, in this case, are:

1.  "patient%1:18:00::" - Basically, the medical definition: someone requiring medical care.
2.  "patient%1:10:00::" - This is the semantic patient role, the thing that undergoes the action, is affected by it.

The context is crystal clear. We're talking about individuals undergoing medical care, not the linguistic concept. The phrase "who have not received chemotherapy" further reinforces this. This isn't some abstract discussion of grammatical roles; it's a very concrete statement about a specific population within a medical setting.

Therefore, the only reasonable interpretation here is sense index 1. No ambiguity to be found!


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicines
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (<t>medicines</t> for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
Here's my analysis of the word "medicines" in the given context:

**Analyzing the Meaning of "Medicines"**

Okay, the target word is "medicines," and the context is "...chemotherapy (<t>medicines</t> for cancer) before...". I need to determine the correct sense of "medicines" here. Let's see...

I've got a few candidates to consider: Sense 1 is about the *field* of medical science, the non-surgical stuff. Sense 2 sounds like it could fit, referring to drugs or medication used to treat diseases. Sense 3 is the *practice* of medicine, the profession itself. And Sense 4 is, well, it's about punishment, completely unrelated!

Given the phrase "medicines for cancer," it's pretty straightforward. We're talking about *pharmaceutical drugs* used to treat cancer. Sense 2, "something that treats or prevents or alleviates the symptoms of disease," is the clear winner. So, the sense index is going to be 2. It's a simple medication context.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for <t>cancer</t>) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
Here's my thought process, as if I were analyzing this:

**Deciphering "Cancer" in Context**

Okay, so the target word is "cancer" within the context of "chemotherapy (medicines for <t>cancer</t>)". Right away, I'm thinking, this is a medical context. Let's run through the senses and see which one makes the most sense here.

*   Sense 1, a malignant growth or tumor, hits the mark immediately. Chemotherapy is, by definition, medication used to treat this kind of disease. That’s the most likely one to be referring to.
*   Sense 2, relating to astrology—a person born under a particular sign—doesn't work at all in the medical setting of chemotherapy. I can dismiss this one outright.
*   Senses 3 and 4, the constellation and astrological sign are equally irrelevant. Chemotherapy isn't related to star signs.
*   Sense 5, the type genus of the Cancridae family, is a zoological definition. Chemotherapy doesn't involve classifications of crabs.

Therefore, considering the medical context of chemotherapy, sense 1, the malignant neoplastic disease, is the intended meaning. This is a straightforward disambiguation. Index 1 it is.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: advanced
Target surface form: advanced
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before <t>advanced</t> or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=advanced%5:00:00:precocious:00 | definition=farther along in physical or mental development | examples=the child's skeletal age was classified as `advanced'; children in the advanced classes in elementary school read far above grade average
2. sense_key=advanced%5:00:00:late:02 | definition=comparatively late in a course of development | examples=the illness had reached an advanced stage; an advanced state of exhaustion
3. sense_key=advanced%5:00:00:progressive:01 | definition=ahead of the times | synonyms=forward-looking, innovative, modern | examples=the advanced teaching methods; had advanced views on the subject
4. sense_key=advanced%5:00:02:high:02 | definition=at a higher level in training or knowledge or skill | examples=an advanced degree; an advanced text in physics
5. sense_key=advanced%5:00:00:high-tech:00 | definition=ahead in development; complex or intricate | synonyms=sophisticated | examples=advanced technology; a sophisticated electronic control system
6. sense_key=advanced%5:00:00:late:00 | definition=far along in time | synonyms=ripe | examples=a man of advanced age; advanced in years
7. sense_key=advanced%5:00:00:civilized:00 | definition=(of societies) highly developed especially in technology or industry | examples=advanced societies; an advanced country technologically
8. sense_key=advanced%5:00:00:front:00 | definition=situated ahead or going before | synonyms=advance, in advance | examples=an advance party; at that time the most advanced outpost was still east of the Rockies

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

content:
```json
{"sense_index": 2}
```

reasoning_content:
**My Analysis of "Advanced" in the Medical Context**

Okay, here's how I'm approaching this. The target word is "advanced" in this phrase: "...advanced or metastatic non-small cell lung cancer...". My immediate instinct is to parse the possible meanings of "advanced" in this medical context. I see several possibilities from the word sense disambiguation (WSD) options, but my focus is on finding the most appropriate definition.

The core of my thought process revolves around the phrase "advanced or metastatic non-small cell lung cancer." Clearly, "advanced" is describing a characteristic of the cancer itself. It's not about training levels, being ahead of the times, or high-tech development. I'm eliminating those immediately.

Looking at the remaining options, sense 2, "comparatively late in a course of development," stands out. The example given, "the illness had reached an advanced stage," is a perfect fit for this medical terminology. This aligns with my clinical understanding. Metastatic cancer is a late stage of cancer, hence the term "advanced" describes the cancer.

Therefore, my final analysis is that sense 2, specifically "comparatively late in a course of development," is the best and most appropriate interpretation of "advanced" in this particular context. It's a clear and concise way to describe the progression of the illness.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cell
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small <t>cell</t> lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
**Analyzing the Meaning of "Cell" in a Medical Context**

Okay, let's break this down. My goal is to pinpoint the exact meaning of "cell" in this phrase: "...before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells." Given the medical nature of the context, I'm expecting a biological interpretation, but it's always good to be thorough.

I've been presented with a few options: a general compartment, a biological unit, an electrical device, a political unit, a mobile phone, a monastic room, and a prison cell. Immediately, some of these can be eliminated. The descriptions of electrical devices, political movements, phones, or physical rooms are clearly irrelevant in a medical context.

Thinking through it, the concept of a "basic structural and functional unit of all organisms" is where my focus lands. Lung cancer, by definition, has to do with biological units, or cells. So, "non-small cell lung cancer" must refer to a type of lung cancer distinguished by the type of cell involved. It's logical, and the provided definition matches perfectly.

Therefore, the intended sense index is 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: affect
Target surface form: affecting
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not <t>affecting</t> the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=affect%2:30:00:: | definition=have an effect upon | synonyms=impact, bear upon, bear on, touch on, touch | examples=Will the new rules affect me?
2. sense_key=affect%2:29:00:: | definition=act physically on; have an effect upon | examples=the medicine affects my heart rate
3. sense_key=affect%2:42:00:: | definition=connect closely and often incriminatingly | synonyms=involve, regard | examples=This new ruling affects your business
4. sense_key=affect%2:32:00:: | definition=make believe with the intent to deceive | synonyms=feign, sham, pretend, dissemble | examples=He feigned that he was ill; He shammed a headache
5. sense_key=affect%2:37:00:: | definition=have an emotional or cognitive impact upon | synonyms=impress, move, strike | examples=This child impressed me as unusually mature; This behavior struck me as odd

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
**Deconstructing the Verb "Affecting" in a Medical Context**

Okay, so I'm looking at this clinical context: "non-small cell lung cancer that is not affecting the squamous cells." The target word is "affecting," and I need to determine the most accurate sense of the word in this phrase. It's a key detail for interpreting the statement accurately.

I've got a few candidate senses lined up, each with its own nuances. Let's start breaking them down. Sense 2, "act physically on; have an effect upon," seems like a decent starting point. The example provided, "the medicine affects my heart rate," resonates – it's a direct physical interaction.

I quickly check WordNet for more context on the "affect" senses, considering synonyms, hypernyms, etc. My focus is still on the physical action or impact.

I'm thinking about the scenario. Does the cancer "act physically on" the squamous cells? Yes, cancer is a biological process that physically interacts with tissues and cells. I briefly considered sense 1, but realized cancer's impact isn't just an abstract influence like a rule change.

I'm now zeroing in on Sense 2: "act physically on." Let's compare and contrast. Sense 1, "have an effect upon," is more abstract, like the effect of a policy. Sense 2 feels right; with a cancer diagnosis, we're talking about a biological agent physically interacting with cells. The medicine and the heart rate example reinforces this.

Therefore, cancer *affecting* the squamous cells means a physical interaction, which is a key concept here. It's not just an "effect," it's a direct biological action. Sense 2 is the clear winner for this clinical context.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: used
Context:
Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is <t>used</t> in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription.

Candidate senses:
1. sense_key=use%2:34:01:: | definition=put into service; make work or employ for a particular purpose or for its inherent or natural purpose | synonyms=utilize, utilise, apply, employ | examples=use your head!; we only use Spanish at home
2. sense_key=use%2:34:02:: | definition=take or consume (regularly or habitually) | synonyms=habituate | examples=She uses drugs rarely
3. sense_key=use%2:34:00:: | definition=use up, consume fully | synonyms=expend | examples=The legislature expended its time on school questions
4. sense_key=use%2:41:14:: | definition=seek or achieve an end by using to one's advantage | examples=She uses her influential friends to get jobs; The president's wife used her good connections
5. sense_key=use%2:41:04:: | definition=avail oneself to | synonyms=practice, apply | examples=apply a principle; practice a religion
6. sense_key=use%2:41:03:: | definition=habitually do something (use only in the past tense) | examples=She used to call her mother every week but now she calls only occasionally; I used to get sick when I ate in that dining hall

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Verb "Used" in a Medical Context**

Okay, so the target word is "used" within the sentence about Alimta. My initial thought is to quickly consider the possible senses, as I know there are a few. Let's see: sense 1, "put into service," sense 2, "take or consume regularly," sense 3, "use up," sense 4, "exploit," sense 5, "avail oneself of," and sense 6, "habitually do something" which is like "used to."

My intuition leans towards "put into service" initially, but let me carefully examine.  Sense 2, "take or consume," feels off at first glance. It's more about the consumer. I pause, though, and reflect on the context. The sentence states, "Alimta is *used* in combination with cisplatin...".  Can a medication *take* itself, or *consume* itself? That feels unnatural in this specific phrasing.

The sentence continues by stating that doctors and caregivers will *employ* or *administer* it. Back to the senses... yes. The context is "Alimta is used to treat two types of cancer..." and "Alimta is used in combination with cisplatin...". I know that it fits much better with sense 1, meaning "put into service," synonyms are utilize, employ.

Sense 2 highlights something more like drug usage *by a person*. The example "She uses drugs rarely" illustrates this perfectly. I am certain that sense 1, "employ/utilize/apply," is the correct one. The "used" in the Alimta context is clearly about its application as a treatment, not its consumption by the drug itself.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in <t>patients</t> who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
Here's my analysis of the word "patients" in this context:

**Analyzing the Meaning of "Patients"**

Okay, so the target word is "patients," with "patient" as its lemma. The surrounding text is: "Alimta is used in combination with cisplatin in <t>patients</t> who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past."

Let's break down the candidate senses. I'm seeing two potential meanings here. Sense 1, which the system has labeled "a person who requires medical care (patient%1:18:00::)" and Sense 2, described as "the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause (patient%1:10:00::)."

Given the sentence structure and the mention of "Alimta," "cisplatin," and "chemotherapy," it's instantly clear that we're dealing with a medical context. The phrase "who have not been treated before" and "who have received another type of chemotherapy" strongly suggests the subject of the sentence, "patients," are indeed people receiving medical treatment.

Therefore, sense 1, "a person who requires medical care," is the accurate interpretation here. This is a straightforward case where the domain knowledge strongly points to the intended meaning. This meaning is indexed as 1, which confirms my intuitive understanding.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: treat
Target surface form: treated
Context:
Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been <t>treated</t> before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription.

Candidate senses:
1. sense_key=treat%2:41:00:: | definition=interact in a certain way | synonyms=handle, do by | examples=Do right by her; Treat him with caution, please
2. sense_key=treat%2:30:01:: | definition=subject to a process or treatment, with the aim of readying for some purpose, improving, or remedying a condition | synonyms=process | examples=process cheese; process hair
3. sense_key=treat%2:29:00:: | definition=provide treatment for | synonyms=care for | examples=The doctor treated my broken leg; The nurses cared for the bomb victims
4. sense_key=treat%2:32:00:: | definition=act on verbally or in some form of artistic expression | synonyms=cover, handle, plow, deal, address | examples=This book deals with incest; The course covered all of Western Civilization
5. sense_key=treat%2:40:00:: | definition=provide with a gift or entertainment | examples=Grandmother always treated us to the circus; I like to treat myself to a day at a spa when I am depressed
6. sense_key=treat%2:34:00:: | definition=provide with choice or abundant food or drink | synonyms=regale | examples=Don't worry about the expensive wine--I'm treating; She treated her houseguests with good food every night
7. sense_key=treat%2:32:03:: | definition=engage in negotiations in order to reach an agreement | examples=they had to treat with the King
8. sense_key=treat%2:31:00:: | definition=regard or consider in a specific way | examples=I treated his advances as a joke

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 3}
```

content:
```json
{"sense_index": 3}
```

reasoning_content:
**Analyzing the Meaning of "Treated" in a Medical Context**

Okay, let's break down this usage of "treated." The sentence is about Alimta and its application to patients, and the key phrase is "have not been treated before." My initial instinct, given the medical setting, is that it pertains to medical care or intervention. Let's look at the possible senses:

1.  "Interact in a certain way" - Unlikely here, too general.
2.  "Subject to a process or treatment, with the aim of readying...improving...remedying..." - This is a possibility, referring to a process.
3.  "Provide treatment for" - This seems like a strong contender; the core meaning of medical care.
4.  "Act on verbally or in some artistic expression" - Definitely not relevant.
5.  "Provide with a gift or entertainment," "provide with choice or abundant food or drink," "engage in negotiations," "regard or consider in a specific way" - These are all obviously irrelevant in this context.

Given the context, the meaning of "treated" must refer to medical care. So, comparing the remaining options: "subject to a process" (Sense 2) or "provide treatment for" (Sense 3). Sense 3, "provide treatment for," seems most directly applicable. Think of "The doctor treated my broken leg." This implies the act of providing medical care.

Now, let's explore sense 3 further: In the hypernym tree of "treat, care for -> remedy, relieve -> care, cure, help," it is clearly medical treatment of patients/illnesses. I am confident Sense 3 is the correct interpretation here. So, "patients who have not been treated before" is correctly understood as "patients who have not received medical treatment before."


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in <t>patients</t> who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Meaning of "Patients"**

Okay, so the target word is "patients," and the context is Alimta treatment. Let's break this down. My initial thought is to consider the possible senses – it's crucial to be precise, especially when dealing with medical terminology.

First, I see the obvious sense, patient%1:18:00::, which is the medical definition: "a person who requires medical care." That's the most likely fit, given the Alimta context – we're obviously talking about people receiving medical treatment.

Then, there's patient%1:10:00::, which relates to semantic roles. That's a linguistic concept, representing an entity affected by a verb. While potentially relevant in a deeper analysis of the sentence structure, it feels entirely out of place here. We're discussing drug administration, not sentence structure.

So, it's a straightforward decision, really. Sense 1, the medical meaning, is the clear winner. This is a pretty basic disambiguation, but it's important to be methodical about it. This level of precision is necessary for this type of medical context.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: type
Target surface form: type
Context:
Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another <t>type</t> of chemotherapy in the past. The medicine can only be obtained with a prescription.

Candidate senses:
1. sense_key=type%1:09:00:: | definition=a subdivision of a particular kind of thing | examples=what type of sculpture do you prefer?
2. sense_key=type%1:18:00:: | definition=a person of a specified kind (usually with many eccentricities) | synonyms=character, eccentric, case | examples=a real character; a strange character
3. sense_key=type%1:14:01:: | definition=(biology) the taxonomic group whose characteristics are used to define the next higher taxon
4. sense_key=type%1:10:01:: | definition=printed characters | examples=small type is hard to read
5. sense_key=type%1:10:00:: | definition=all of the tokens of the same symbol | examples=the word `element' contains five different types of character
6. sense_key=type%1:06:00:: | definition=a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper | examples=he dropped a case of type, so they made him pick them up

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Meaning of "Type" in a Medical Context**

Okay, let's break down this "type" usage within the sentence: "...in patients who have received another <t>type</t> of chemotherapy in the past." My initial thought is to run through the possible senses of "type" that I'm familiar with, given my expertise. I need to zero in on the intended meaning in this medical context.

I see several possibilities: a subdivision or kind of something, a person of a particular kind (which doesn't fit here, obviously!), a taxonomic group (biologically relevant, but unlikely here), printed characters (definitely not), all tokens of the same symbol (again, not applicable), and a small metal block (completely irrelevant).

The phrase "another type of chemotherapy" strongly suggests we're talking about a *kind* or *variety* of chemotherapy. The patient is already being treated with one type, and we're referring to a *different* type they've had in the past. This makes sense_key=type%1:09:00:: the most relevant one. The definition "a subdivision of a particular kind of thing" fits perfectly. So, the meaning is clear: "another kind of chemotherapy." Case closed.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: past
Target surface form: past
Context:
Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the <t>past</t>. The medicine can only be obtained with a prescription.

Candidate senses:
1. sense_key=past%1:28:00:: | definition=the time that has elapsed | synonyms=past times, yesteryear | examples=forget the past
2. sense_key=past%1:28:01:: | definition=a earlier period in someone's life (especially one that they have reason to keep secret) | examples=reporters dug into the candidate's past
3. sense_key=past%1:10:00:: | definition=a verb tense that expresses actions or states in the past | synonyms=past tense

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
**Disambiguating "Past" in a Clinical Context**

Okay, let's break down this use of "past" in the phrase "...in patients who have received another type of chemotherapy in the *past*." My expert intuition immediately tells me we're dealing with a temporal context, but let's be rigorous. I need to make sure I consider all potential interpretations.

First, I need to consider the candidate senses:

1.  "The time that has elapsed" – that's a classic, straightforward definition of time gone by. Fits what I'm expecting.
2.  "An earlier period in someone's life" - While the phrase 'in the past' can relate to periods of time in a persons life, it doesn't quite fit the context.
3.  "A verb tense" – definitely not relevant here. That's about grammar, not clinical history.

Given the phrase "in the past" that the text gave, it is almost certain it is referring to the time that has elapsed. I am highly confident that the use of "past" here means time in the past. Therefore, with a high degree of certainty, it is sense index 1, where "past" represents the time that has elapsed.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The <t>medicine</t> can only be obtained with a prescription. How is Alimta used?

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
**My Analysis of "Medicine" in Context**

Okay, let's break this down. The target word is "medicine," and the sentence reads, "The *medicine* can only be obtained with a prescription." Right away, I start sifting through my mental dictionary of possible senses. I've got a few candidates:

*   **Sense 1:** Seems to refer to the *field* of medical science itself, the non-surgical techniques. That doesn't quite fit the context. I'm looking for something tangible. I can't see the context referring to this.
*   **Sense 2:** This is promising. "Something that treats or prevents or alleviates the symptoms of disease." That sounds like a *medication* or *medicament*. This feels like the right track.
*   **Sense 3:** This refers to the *profession* itself, the learned discipline. Again, not fitting the way that the word "medicine" is used here. Doesn't quite relate to the prescription aspect.
*   **Sense 4:** This sounds like punishment, not fitting here.

Now, the context mentions "Alimta," a prescription drug. That seals the deal. "Alimta" is a tangible *medication*. Therefore, sense 2 is the correct one. The sense index is clearly 2. It's that simple, I think.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: only
Target surface form: only
Context:
It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can <t>only</t> be obtained with a prescription. How is Alimta used?

Candidate senses:
1. sense_key=only%4:02:02:: | definition=and nothing more | synonyms=merely, simply, just, but | examples=I was merely asking; it is simply a matter of time
2. sense_key=only%4:02:01:: | definition=without any others being included or involved | synonyms=entirely, exclusively, solely, alone | examples=was entirely to blame; a school devoted entirely to the needs of problem children
3. sense_key=only%4:02:00:: | definition=with nevertheless the final result | examples=He arrived only to find his wife dead; We won only to lose again in the next round
4. sense_key=only%4:02:04:: | definition=in the final outcome | examples=These news will only make you more upset
5. sense_key=only%4:02:06:: | definition=except that | examples=It was the same story; only this time she came out better
6. sense_key=only%4:02:03:: | definition=never except when | synonyms=only if, only when | examples=call me only if your cold gets worse
7. sense_key=only%4:02:05:: | definition=as recently as | examples=I spoke to him only an hour ago

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
**Deconstructing the Ambiguity of "Only"**

Okay, so I'm presented with the word "only" in the sentence "The medicine can only be obtained with a prescription," and I need to figure out its precise meaning. My initial instinct is to run through the possible senses: "merely," "exclusively," "in the final result," "except that," "only if," and even "as recently as," although that last one seems a long shot.

I immediately start to hone in on the contenders: sense 2 ("exclusively") versus sense 6 ("only if").  I test sense 2 by substituting synonyms like "exclusively" or "solely." "The medicine can exclusively be obtained with a prescription." Does that work?  It feels right, but I have to be careful. Sense 6 intrigues me because it links "only" to a condition ("never except when"), which makes me think of "only if" or "only when."  I start to consider whether the implication is, "the medicine can be obtained never except with a prescription."

I then double-check the synonyms in my mind. Sense 2: synonyms are "entirely, exclusively, solely, alone," which matches the definition, “without any others being included or involved.” That’s a good sign. Sense 6 has “only if, only when.” I consult WordNet to verify. It confirms that the synonyms are accurate. I check the definitions and examples in WordNet to be absolutely certain.

I keep coming back to "exclusively." Does the sentence imply that the medicine can *solely* be obtained with a prescription?  Yes, that’s it.  I ask myself if the word "only" is modifying the prepositional phrase ("with a prescription") here, but then I remember that even though the word order is "only be obtained," the meaning is still "exclusively with." The "only" restricts the prescription.

So I cycle back through the possibilities: "merely," "exclusively," and "only if." I realize that "merely" is not a fit, and "only if" doesn’t quite capture the restriction in this sentence. Then I look back at WordNet.

I look at the synonyms for "merely." I reject this sense because the sentence has more restrictive semantics. I look at the synonyms for "exclusively." I see it can be synonymous with "solely" or "alone," and that is the key. I review the WordNet definitions again and the examples. I realize that the correct sense of "only" here is "exclusively." "The medicine can only be obtained with a prescription" is equivalent to saying, "The medicine can be obtained exclusively with a prescription."


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: obtain
Target surface form: obtained
Context:
It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be <t>obtained</t> with a prescription. How is Alimta used?

Candidate senses:
1. sense_key=obtain%2:40:00:: | definition=come into possession of | examples=How did you obtain the visa?
2. sense_key=obtain%2:30:00:: | definition=receive a specified treatment (abstract) | synonyms=receive, get, find, incur | examples=These aspects of civilization do not find expression or receive an interpretation; His movie received a good review
3. sense_key=obtain%2:42:00:: | definition=be valid, applicable, or true | synonyms=prevail, hold | examples=This theory still holds

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**My Analysis of "Obtained" in Context**

Alright, let's break this down. The target word is "obtained," and the context is "The medicine can only be obtained with a prescription." My goal is to pinpoint the correct sense of "obtained" here, and the provided senses are:

1.  "come into possession of"
2.  "receive a specified treatment (abstract)"
3.  "be valid, applicable, or true"

Given my understanding of this field, it's immediately clear that "The medicine can only be obtained with a prescription" is about *acquiring* the medicine. It's not about receiving some abstract treatment (sense 2), nor is it about something being valid or true (sense 3). Instead, it's about the act of *getting* the medicine, of coming into possession of it. This directly aligns with the definition of sense 1 (sense\_key=obtain%2:40:00::). Therefore, my conclusion is that sense 1 is the correct one in this specific context.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: prescription
Target surface form: prescription
Context:
It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a <t>prescription</t>. How is Alimta used?

Candidate senses:
1. sense_key=prescription%1:10:00:: | definition=directions prescribed beforehand; the action of prescribing authoritative rules or directions | examples=I tried to follow her prescription for success
2. sense_key=prescription%1:06:00:: | definition=a drug that is available only with written instructions from a doctor or dentist to a pharmacist | synonyms=prescription drug, prescription medicine, ethical drug | examples=he told the doctor that he had been taking his prescription regularly
3. sense_key=prescription%1:10:02:: | definition=written instructions for an optician on the lenses for a given person
4. sense_key=prescription%1:10:01:: | definition=written instructions from a physician or dentist to a druggist concerning the form and dosage of a drug to be issued to a given patient

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 4}
```

content:
```json
{"sense_index": 4}
```

reasoning_content:
**Analyzing the Context of "Prescription"**

Okay, so the word I need to disambiguate is "prescription," and the sentence I'm given is "The medicine can only be obtained with a prescription." Right away, I start running through the potential senses. I've got a few: rules or directions, the drug itself (prescription drug), instructions for an optician, and written instructions for a pharmacist.

My initial thought is to lean towards written instructions for a pharmacist (Sense 4), since the sentence talks about *obtaining* medicine. Then I see the sense, a drug that is available only *with* written instructions... Hang on. If it were the drug itself, the sentence would be "The medicine can only be obtained with a *prescription drug*." That doesn't make sense. The medicine is obtained WITH a *prescription* (the document).

So, eliminating that, I go back to Sense 4: written instructions for a pharmacist. That works perfectly. It's the document that's required to get the medicine. But let me just quickly run through the others. The rule/direction sense doesn't fit the context; it's too general. And written instructions for an optician doesn't fit, given the context.

Yes, sense 4 is the clear winner, with the other senses easily rejected. This is quite straightforward.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: used
Context:
What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta <t>used</t>? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy.

Candidate senses:
1. sense_key=use%2:34:01:: | definition=put into service; make work or employ for a particular purpose or for its inherent or natural purpose | synonyms=utilize, utilise, apply, employ | examples=use your head!; we only use Spanish at home
2. sense_key=use%2:34:02:: | definition=take or consume (regularly or habitually) | synonyms=habituate | examples=She uses drugs rarely
3. sense_key=use%2:34:00:: | definition=use up, consume fully | synonyms=expend | examples=The legislature expended its time on school questions
4. sense_key=use%2:41:14:: | definition=seek or achieve an end by using to one's advantage | examples=She uses her influential friends to get jobs; The president's wife used her good connections
5. sense_key=use%2:41:04:: | definition=avail oneself to | synonyms=practice, apply | examples=apply a principle; practice a religion
6. sense_key=use%2:41:03:: | definition=habitually do something (use only in the past tense) | examples=She used to call her mother every week but now she calls only occasionally; I used to get sick when I ate in that dining hall

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**My Analysis of "Used" in the Alimta Context**

Okay, the target word is "used" in the context of "How is Alimta used?". My task is to determine the most accurate sense from a list of possibilities. I'm going through the candidate senses: *use%2:34:01* (employ, utilize), *use%2:34:02* (take or consume), *use%2:34:00* (use up), *use%2:41:14* (achieve an end by using to one's advantage), *use%2:41:04* (avail oneself), and *use%2:41:03* (habitually do something).

First, I'm focusing on the first two options because they seem most relevant. Sense 2, "take or consume," feels immediately less likely. The example "She uses drugs rarely" highlights that this sense pertains to an agent consuming something. But Alimta is the *object* in the question, the thing being "used," which means that *I* use the drug, not the other way around. My first instinct is to assume a passive voice and that Alimta can't be *used* in the same way that someone uses a drug.

I'm thinking: "How is Alimta used?" – Is it about how a doctor applies it? Is it about its purpose? The phrase "Alimta should only be given under the supervision of a doctor" is a clue. It's about its *administration* or *application*. That pushes me back to sense 1: "put into service; make work or employ for a particular purpose." This aligns with synonyms like "apply," "employ," and "utilize," which feel right.

Now, to solidify my choice. I'm carefully considering the "habituate" implication of sense 2. The definition, "take or consume (regularly or habitually)," strongly indicates substance use or personal intake, not how a medicine *functions*. The passive construction of the phrase "Alimta is used" doesn't fit with this sense because it implies that the drug is the agent.

So, I'm confirming that sense 1 fits better. "How is Alimta employed/applied/put into service?" This reads correctly, especially since the following sentence mentions a doctor. "What is Alimta used for? Alimta is used to treat two types of cancer... How is Alimta used? Alimta should only be given under the supervision of a doctor..." Sense 1 is the best fit. I'm confident. I'm going with "put into service; make work or employ for a particular purpose" and, therefore, that this is the best sense of "used" in this context.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: only
Target surface form: only
Context:
Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should <t>only</t> be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight).

Candidate senses:
1. sense_key=only%4:02:02:: | definition=and nothing more | synonyms=merely, simply, just, but | examples=I was merely asking; it is simply a matter of time
2. sense_key=only%4:02:01:: | definition=without any others being included or involved | synonyms=entirely, exclusively, solely, alone | examples=was entirely to blame; a school devoted entirely to the needs of problem children
3. sense_key=only%4:02:00:: | definition=with nevertheless the final result | examples=He arrived only to find his wife dead; We won only to lose again in the next round
4. sense_key=only%4:02:04:: | definition=in the final outcome | examples=These news will only make you more upset
5. sense_key=only%4:02:06:: | definition=except that | examples=It was the same story; only this time she came out better
6. sense_key=only%4:02:03:: | definition=never except when | synonyms=only if, only when | examples=call me only if your cold gets worse
7. sense_key=only%4:02:05:: | definition=as recently as | examples=I spoke to him only an hour ago

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
**Analyzing the Nuances of "Only" in a Clinical Context**

Okay, so I'm presented with the sentence "Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy." My immediate thought is, "What kind of 'only' are we dealing with here?" The word 'only' is so subtle, but it can drastically change the meaning.

I start by considering the different senses this word can convey. I'm focusing on the core meanings here: is it about *exclusivity* or is it more about a *conditional* restriction? Does it mean Alimta should only be given to a patient in a very specific situation?

My first instinct is to see how I'd naturally rephrase this. I'm drawn to exploring sense 2, which speaks of *exclusivity* - "without any others being included or involved."  Could this mean "Alimta should be given *exclusively* under the supervision..." or perhaps "solely under the supervision..."? That makes a lot of sense, because as an expert in my field, that's how I'd interpret the phrase.

I have to carefully evaluate the context, though. Sense 6 keeps popping up: "never except when."  Is "under the supervision" a conditional clause, which would then be implied by sense 6? The wording is important. I note that this sense has synonyms like "only if" or "only when". Does that phrasing fit?  If so, I'd understand that "Alimta should *only* be given under the supervision..." is synonymous with "Alimta should be given *only when* under the supervision..." However, the text implies that this is a *requirement* rather than a *conditional*.

I need to confirm if it means it should never be given in a situation *except* under the supervision of a doctor. But no, the prepositional phrase doesn't fit a clause with 'if' or 'when'. That usage feels less natural in this instance.

I return to sense 2: "without any others being included or involved."  This sense seems right.  I check again: synonyms are "entirely, exclusively, solely, alone." The example is "a school devoted entirely to the needs of problem children." I can see that clearly applying here. "Alimta should be given *solely* under the supervision..." or "exclusively under the supervision..."

To double-check, I look at sense 1: "and nothing more", like saying "I was merely asking". No, that's not about restriction to a specific condition or group.

I dig a little deeper. I'm used to seeing phrases like "available only to members" or "only under the supervision of." The phrase "only under the supervision of..." is similar to standard expressions like "The medicine can *only* be obtained with a prescription." This confirms my belief.

I think, "Yes, sense 2 is the most appropriate interpretation." I can rephrase the sentence as: "Alimta should be given solely under the supervision of..." It aligns with established medical protocols and standard English usage. I'm confident. Sense 2 (index 2) is the correct interpretation.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: give
Target surface form: given
Context:
Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be <t>given</t> under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight).

Candidate senses:
1. sense_key=give%2:40:03:: | definition=cause to have, in the abstract sense or physical sense | examples=She gave him a black eye; The draft gave me a cold
2. sense_key=give%2:40:05:: | definition=be the cause or source of | synonyms=yield, afford | examples=He gave me a lot of trouble; Our meeting afforded much interesting information
3. sense_key=give%2:40:00:: | definition=transfer possession of something concrete or abstract to somebody | examples=I gave her my money; can you give me lessons?
4. sense_key=give%2:40:07:: | definition=convey or reveal information | examples=Give one's name
5. sense_key=give%2:32:01:: | definition=convey, as of a compliment, regards, attention, etc.; bestow | synonyms=pay | examples=Don't pay him any mind; give the orders
6. sense_key=give%2:36:02:: | definition=organize or be responsible for | synonyms=hold, throw, have, make | examples=hold a reception; have, throw, or make a party
7. sense_key=give%2:32:00:: | definition=convey or communicate; of a smile, a look, a physical gesture | synonyms=throw | examples=Throw a glance; She gave me a dirty look
8. sense_key=give%2:40:01:: | definition=give as a present; make a gift of | synonyms=gift, present | examples=What will you give her for her birthday?
9. sense_key=give%2:36:03:: | definition=cause to happen or be responsible for | synonyms=yield | examples=His two singles gave the team the victory
10. sense_key=give%2:31:02:: | definition=dedicate | synonyms=pay, devote | examples=give thought to; give priority to
11. sense_key=give%2:36:00:: | definition=give or supply | synonyms=render, yield, return, generate | examples=The cow brings in 5 liters of milk; This year's crop yielded 1,000 bushels of corn
12. sense_key=give%2:40:09:: | definition=transmit (knowledge or skills) | synonyms=impart, leave, pass on | examples=give a secret to the Russians; leave your name and address here
13. sense_key=give%2:36:01:: | definition=bring about | synonyms=establish | examples=The trompe l'oeil-illusion establishes depth
14. sense_key=give%2:40:02:: | definition=leave with; give temporarily | examples=Can I give you my keys while I go in the pool?; Can I give you the children for the weekend?
15. sense_key=give%2:41:00:: | definition=emit or utter | examples=Give a gulp; give a yelp
16. sense_key=give%2:40:10:: | definition=endure the loss of | synonyms=sacrifice | examples=He gave his life for his children; I gave two sons to the war
17. sense_key=give%2:40:06:: | definition=place into the hands or custody of | synonyms=pass, hand, reach, pass on, turn over | examples=hand me the spoon, please; Turn the files over to me, please
18. sense_key=give%2:32:03:: | definition=give entirely to a specific person, activity, or cause | synonyms=dedicate, consecrate, commit, devote | examples=She committed herself to the work of God; give one's talents to a good cause
19. sense_key=give%2:40:13:: | definition=give (as medicine) | examples=I gave him the drug
20. sense_key=give%2:40:14:: | definition=give or convey physically | synonyms=apply | examples=She gave him First Aid; I gave him a punch in the nose
21. sense_key=give%2:32:02:: | definition=bestow | synonyms=render | examples=give homage; render thanks
22. sense_key=give%2:40:11:: | definition=bestow, especially officially | synonyms=grant | examples=grant a degree; give a divorce
23. sense_key=give%2:38:00:: | definition=move in order to make room for someone for something | synonyms=move over, give way, ease up, yield | examples=The park gave way to a supermarket; `Move over,' he told the crowd
24. sense_key=give%2:34:00:: | definition=give food to | synonyms=feed | examples=Feed the starving children in India; don't give the child this tough meat
25. sense_key=give%2:40:08:: | definition=contribute to some cause | synonyms=contribute, chip in, kick in | examples=I gave at the office
26. sense_key=give%2:38:13:: | definition=break down, literally or metaphorically | synonyms=collapse, fall in, cave in, give way, break, founder | examples=The wall collapsed; The business collapsed
27. sense_key=give%2:31:00:: | definition=estimate the duration or outcome of something | examples=He gave the patient three months to live; I gave him a very good chance at success
28. sense_key=give%2:41:10:: | definition=execute and deliver | examples=Give bond
29. sense_key=give%2:40:12:: | definition=deliver in exchange or recompense | examples=I'll give you three books for four CDs
30. sense_key=give%2:40:15:: | definition=afford access to | synonyms=afford, open | examples=the door opens to the patio; The French doors give onto a terrace
31. sense_key=give%2:36:13:: | definition=present to view | examples=He gave the sign to start
32. sense_key=give%2:36:12:: | definition=perform for an audience | examples=Pollini is giving another concert in New York
33. sense_key=give%2:35:00:: | definition=be flexible under stress of physical force | synonyms=yield | examples=This material doesn't give
34. sense_key=give%2:34:10:: | definition=propose | examples=He gave the first of many toasts at the birthday party
35. sense_key=give%2:32:11:: | definition=accord by verdict | examples=give a decision for the plaintiff
36. sense_key=give%2:32:08:: | definition=manifest or show | examples=This student gives promise of real creativity; The office gave evidence of tampering
37. sense_key=give%2:32:15:: | definition=offer in good faith | examples=He gave her his word
38. sense_key=give%2:32:14:: | definition=submit for consideration, judgment, or use | examples=give one's opinion; give an excuse
39. sense_key=give%2:32:09:: | definition=guide or direct, as by behavior of persuasion | examples=You gave me to think that you agreed with me
40. sense_key=give%2:32:07:: | definition=allow to have or take | examples=I give you two minutes to respond
41. sense_key=give%2:32:10:: | definition=inflict as a punishment | examples=She gave the boy a good spanking; The judge gave me 10 years
42. sense_key=give%2:30:13:: | definition=occur | examples=what gives?
43. sense_key=give%2:29:11:: | definition=consent to engage in sexual intercourse with a man | examples=She gave herself to many men
44. sense_key=give%2:29:10:: | definition=proffer (a body part) | examples=She gave her hand to her little sister

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{
  "sense_index": 19
}
```

content:
```json
{
  "sense_index": 19
}
```

reasoning_content:
**Analyzing the Word "Given" in Context**

Okay, so the target word is "given," stemming from "give." Let's see... the surrounding text mentions "Alimta," which is clearly a medication. Phrases like "under the supervision of a doctor," "anticancer chemotherapy," and "recommended dose" all point towards Alimta being a drug. We're reading: "Alimta should only be given..." That screams medical administration.

Now to the senses. Let's consider the candidates. Sense 19, "give (as medicine)," has that definition which immediately jumps out. There's even an example, "I gave him the drug," which mirrors the situation we're analyzing. Sense 20, "give or convey physically," while potentially applicable in some very abstract scenarios, doesn't really fit the medical context here, and the definition feels off. Sense 3, "transfer possession," is too broad for this specific usage.

Therefore, given the context of a drug being administered, Sense 19 is the best fit. It's the most specific and aligned with the meaning we're extracting from the text. This is a clear case of "given" meaning "administered as medicine."


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: doctor
Target surface form: doctor
Context:
Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a <t>doctor</t> who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight).

Candidate senses:
1. sense_key=doctor%1:18:00:: | definition=a licensed medical practitioner | synonyms=doc, physician, MD, Dr., medico | examples=I felt so bad I went to see my doctor
2. sense_key=doctor%1:18:02:: | definition=(Roman Catholic Church) a title conferred on 33 saints who distinguished themselves through the orthodoxy of their theological teaching | synonyms=Doctor of the Church | examples=the Doctors of the Church greatly influenced Christian thought down to the late Middle Ages
3. sense_key=doctor%1:04:00:: | definition=children take the roles of physician or patient or nurse and pretend they are at the physician's office | examples=the children explored each other's bodies by playing the game of doctor
4. sense_key=doctor%1:18:01:: | definition=a person who holds Ph.D. degree (or the equivalent) from an academic institution | synonyms=Dr. | examples=she is a doctor of philosophy in physics

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**My Analysis of "Doctor" in Context**

Alright, let's break this down. The target word is "doctor," and the sentence clearly specifies "Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy." My expertise immediately flags several potential senses for "doctor," and I need to select the right one.

First, I consider the possible senses: a licensed medical practitioner, a title within the Roman Catholic Church, a role played by children, and someone holding a Ph.D. After quick consideration, the context of anticancer chemotherapy immediately rules out the other options. The description, "qualified in the use of anticancer chemotherapy," points unmistakably to the sense of a licensed medical professional – the physician. It’s the only definition that fits the medical context, so there’s no room for debate here. I’m quite confident that the correct sense to use is sense index 1: a licensed medical practitioner. Case closed.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: use
Context:
Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the <t>use</t> of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight).

Candidate senses:
1. sense_key=use%1:04:00:: | definition=the act of using | synonyms=usage, utilization, utilisation, employment, exercise | examples=he warned against the use of narcotic drugs; skilled in the utilization of computers
2. sense_key=use%1:07:00:: | definition=what something is used for | synonyms=function, purpose, role | examples=the function of an auger is to bore holes; ballet is beautiful but what use is it?
3. sense_key=use%1:07:02:: | definition=a particular service | examples=he put his knowledge to good use; patrons have their uses
4. sense_key=use%1:22:00:: | definition=(economics) the utilization of economic goods to satisfy needs or in manufacturing | synonyms=consumption, economic consumption, usance, use of goods and services | examples=the consumption of energy has increased steadily
5. sense_key=use%1:04:01:: | definition=(psychology) an automatic pattern of behavior in reaction to a specific situation; may be inherited or acquired through frequent repetition | synonyms=habit | examples=owls have nocturnal habits; she had a habit twirling the ends of her hair
6. sense_key=use%1:04:02:: | definition=exerting shrewd or devious influence especially for one's own advantage | synonyms=manipulation | examples=his manipulation of his friends was scandalous
7. sense_key=use%1:07:03:: | definition=(law) the exercise of the legal right to enjoy the benefits of owning property | synonyms=enjoyment | examples=we were given the use of his boat

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Senses of "Use" in a Medical Context**

Okay, let's break this down. The challenge is to identify the most accurate indexed sense of "use" within the phrase "qualified in the *use* of anticancer chemotherapy." I need to sift through the potential senses and choose the best fit based on the context.

I see a list of potential senses: I'm presented with these candidates:
*   **sense\_key=use%1:04:00::**: the act of using (with synonyms like usage, utilization, employment, exercise)
*   **sense\_key=use%1:07:00::**: what something is used for (function, purpose, role)
*   **sense\_key=use%1:07:02::**: a particular service
*   **sense\_key=use%1:22:00::**: the utilization of economic goods
*   **sense\_key=use%1:04:01::**: an automatic pattern of behavior
*   **sense\_key=use%1:04:02::**: exerting influence for one's own advantage
*   **sense\_key=use%1:07:03::**: the exercise of the legal right to enjoy the benefits of owning property

The context, "qualified in the use of anticancer chemotherapy," points towards the act of employing, administering, or utilizing the chemotherapy. It's about practical application and a skill set.

Now, let's evaluate them against that context. Sense 2, 3, 4, 5, 6, and 7 seem irrelevant. However, Sense 1 immediately resonates. The definition "the act of using" aligns perfectly with the idea of a doctor's qualification regarding chemotherapy. The inclusion of synonyms like "utilization" and "employment" are useful.

The provided example: "skilled in the utilization of computers" is a great reference point. It's a precise parallel to "qualified in the use of anticancer chemotherapy". The construction is nearly identical: competence and qualification in using something. This helps to confirm my assessment.

Therefore, the first sense, `use%1:04:00::` appears to be the most appropriate choice. That's the one I'd select. The index is 1.