[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: likely
Target surface form: likely
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is <t>likely</t> to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=likely%5:00:00:credible:00 | definition=within the realm of credibility | examples=not a very likely excuse
2. sense_key=likely%3:00:00:: | definition=has a good chance of being the case or of coming about | examples=these services are likely to be available to us all before long; she is likely to forget
3. sense_key=likely%3:00:04:: | definition=likely but not certain to be or become true or real | synonyms=probable | examples=a likely result; he foresaw a probable loss
4. sense_key=likely%5:00:00:prospective:00 | definition=expected to become or be; in prospect | synonyms=potential | examples=potential clients

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
**Analyzing the Nuances of "Likely"**

Okay, so the target word is "likely" in the phrase "or is likely to spread easily, to other parts of the body". My mind immediately jumps to a few different senses. It's not *just* about probability; there's a strong element of expectation here, a sense of something being highly probable. The phrase "likely to spread" implies an anticipation, a high chance of this event occurring.

Let's break down the candidate senses I'm considering. We have "credible," which feels a bit off in this context. It's not about the plausibility of an excuse. Then there's "has a good chance of being the case or coming about"—that seems promising. Think of examples like "she is likely to forget" or "these services are likely to be available." Next, "likely but not certain," which is very similar to "probable." Finally, "expected to become or be; in prospect," which implies potential.

Aha! "Likely to spread" *definitely* fits the "has a good chance of being the case" sense. It aligns perfectly with that "likely + to + infinitive" syntactic pattern. It's about expectation, not just possibility. I'm verifying this now with the definition: "has a good chance of being the case or of coming about." This includes "these services are likely to be available to us all before long; she is likely to forget."

And just to be extra sure, the "probable" sense is often used attributively or predicatively with nominals, which doesn't quite fit the context. Therefore, Sense 2 is the clear winner.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: spread
Target surface form: spread
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to <t>spread</t> easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=spread%2:35:07:: | definition=become distributed or widespread | synonyms=propagate | examples=the infection spread; Optimism spread among the population
2. sense_key=spread%2:32:00:: | definition=cause to become widely known | synonyms=circulate, circularize, circularise, distribute, disseminate, propagate | examples=spread information; circulate a rumor
3. sense_key=spread%2:35:03:: | definition=spread out or open from a closed or folded state | synonyms=unfold, spread out, open | examples=open the map; spread your arms
4. sense_key=spread%2:35:12:: | definition=cover by spreading something over | examples=spread the bread with cheese
5. sense_key=spread%2:38:00:: | definition=strew or distribute over an area | synonyms=scatter, spread out | examples=He spread fertilizer over the lawn; scatter cards across the table
6. sense_key=spread%2:32:02:: | definition=become widely known and passed on | synonyms=go around, circulate | examples=the rumor spread; the story went around in the office
7. sense_key=spread%2:42:00:: | definition=spread across or over | synonyms=overspread | examples=A big oil spot spread across the water
8. sense_key=spread%2:38:02:: | definition=move outward | synonyms=diffuse, spread out, fan out | examples=The soldiers fanned out
9. sense_key=spread%2:35:13:: | definition=distribute over a surface in a layer | examples=spread cheese on a piece of bread
10. sense_key=spread%2:35:00:: | definition=distribute or disperse widely | synonyms=distribute | examples=The invaders spread their language all over the country

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

finish_reason: stop

content:
```json
{"sense_index": 1}
```

role: assistant

reasoning_content:
**Analyzing the Semantic Landscape of "Spread" in Oncology**

Okay, so the task at hand is to pinpoint the correct sense of "spread" in the very specific context of cancer metastasis – the process of cancer cells distributing and extending to other parts of the body. Given my expertise, I'm thinking, this is all about the *movement* and *distribution* of cancerous cells.

Let's look at these candidate senses. I'm seeing a lot of possibilities, but I need to be precise.
*   "Spread%2:35:07::" looks promising as it means 'become distributed or widespread'. This looks like it can be the best.
*   Sense 2 is "cause to become widely known," which doesn't fit the biological context.
*   Sense 3 is about opening/unfolding, no.
*   Sense 4 is about applying something over a surface... no.
*   Sense 5 refers to distributing something over an area.
*   Sense 6, 'become widely known and passed on' is close to sense 2.
*   Sense 7, 'spread across or over' is also a contender.
*   Sense 8, 'move outward, diffuse'.
*   Sense 9 is like Sense 4.
*   Sense 10, 'distribute or disperse widely (transitive)'.

Focusing back on this context, Sense 1, "become distributed or widespread," is looking like the frontrunner. It's essentially the same process as an infection spreading, which is the perfect analog for cancer metastasis. Sense 1 gives "the infection spread" as an example of this usage, which matches the context.

Now, let's contrast this with Sense 7, "spread across or over," and Sense 8, "move outward". Sense 8 might be tempting, but it has a more physical, spatial connotation. "The soldiers fanned out" is the example for Sense 8, which is an intransitive verb, where Sense 1 also contains the example of an intransitive verb, "the infection spread." Sense 1 captures this aspect more accurately than sense 8.

The phrase "malignant (has spread, or is likely to spread easily, to other parts of the body)" screams for an intransitive verb, and Sense 1's "become distributed or widespread" hits the mark exactly. It's the best fit in this context, so that's the one I'm selecting.

type: thinking

service_tier: default

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: easily
Target surface form: easily
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread <t>easily</t>, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=easily%4:02:05:: | definition=indicating high probability; in all likelihood | synonyms=well | examples=I might well do it; a mistake that could easily have ended in disaster
2. sense_key=easily%4:02:01:: | definition=with ease (`easy' is sometimes used informally for `easily') | synonyms=easy | examples=she was easily excited; was easily confused
3. sense_key=easily%4:02:06:: | definition=without question | examples=easily the best book she's written

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

content:
```json
{"sense_index": 2}
```

reasoning_content:
**Analyzing the Nuances of "Easily"**

Okay, so the target is "easily," and the surface form matches. The context is "...likely to spread easily, to other parts of the body...". Let's run through the candidates:

*   **Sense 1**: "indicating high probability; in all likelihood." Hmm, the example is "could easily have ended in disaster". But we've already got "likely to spread." Saying "likely to spread in all likelihood" feels redundant, doesn't it? It just doesn't sit right.

*   **Sense 2**: "with ease" — just like the example: "was easily confused".

*   **Sense 3**: "without question." Doesn't fit at all.

So, the phrase, "...likely to spread easily..." suggests that it spreads readily, or without much effort. The context indicates capacity or ability, not probability, although high probability is implied. It means it spreads *with ease*. That lines up perfectly with sense 2, "with ease." "Easy" is even the synonym. That seems to be the one!

Just to be absolutely sure, let's revisit that context: "...likely to spread easily, to other parts of the body...". It means it spreads with ease, and is easy to spread. Again, this points towards sense 2: "easily%4:02:01:: | definition=with ease".

Yep, sense 2 it is.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: other
Target surface form: other
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to <t>other</t> parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=other%5:00:00:strange:00 | definition=very unusual; different in character or quality from the normal or expected; - Lance Morrow | examples=a strange, other dimension...where his powers seemed to fail
2. sense_key=other%5:00:02:past:00 | definition=belonging to the distant past | synonyms=early, former | examples=the early inhabitants of Europe; former generations
3. sense_key=other%5:00:00:past:00 | definition=recently past | examples=the other evening
4. sense_key=other%3:00:00:: | definition=not the same one or ones already mentioned or implied; - the White Queen | examples=today isn't any other day; the construction of highways and other public works

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
**Deconstructing "Other"**

Okay, so I'm dissecting this phrase, "spread easily, to other parts of the body." My immediate instinct, being the seasoned professional I am, is to pinpoint the specific nuance of "other" here. The context is key, and I'm parsing its implications.

The wording directs my attention to body parts that haven't been explicitly mentioned or, presumably, are unaffected at this point. That's the core constraint. Now, let's consider the possible senses. We've got:

1.  Strange, different
2.  Early, former
3.  Recently past
4.  Not the same one or ones already mentioned or implied.

Given the context of a spread within a biological system, I can quickly eliminate the first three options. "Different," "former," or "past" simply don't fit the mechanistic relationship. The phrase clearly conveys a new location, a location distinct from the currently infected site. Therefore, option 4 is the winner. "Other" in this case unambiguously means *not the same* as what's been identified earlier in the text or is currently implied. It's a precise spatial and topological delineation within a broader system.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: part
Target surface form: parts
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other <t>parts</t> of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=part%1:04:03:: | definition=the part played by a person in bringing about a result | synonyms=contribution, share | examples=I am proud of my contribution in advancing the project; they all did their share of the work
2. sense_key=part%1:15:00:: | definition=the extended spatial location of something | synonyms=region | examples=the farming regions of France; religions in all parts of the world
3. sense_key=part%1:21:00:: | definition=assets belonging to or due to or contributed by an individual person or group | synonyms=share, portion, percentage | examples=he wanted his share in cash
4. sense_key=part%1:06:00:: | definition=something less than the whole of a human artifact | synonyms=portion | examples=the rear part of the house; glue the two parts together
5. sense_key=part%1:09:00:: | definition=one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division | examples=the written part of the exam; the finance section of the company
6. sense_key=part%1:24:00:: | definition=something determined in relation to something that includes it | synonyms=portion, component part, component, constituent | examples=he wanted to feel a part of something bigger than himself; I read a portion of the manuscript
7. sense_key=part%1:17:00:: | definition=a portion of a natural object | synonyms=piece | examples=they analyzed the river into three parts; he needed a piece of granite
8. sense_key=part%1:09:01:: | definition=an actor's portrayal of someone in a play | synonyms=character, role, theatrical role, persona | examples=she played the part of Desdemona
9. sense_key=part%1:10:00:: | definition=the melody carried by a particular voice or instrument in polyphonic music | synonyms=voice | examples=he tried to sing the tenor part
10. sense_key=part%1:08:01:: | definition=a line of scalp that can be seen when sections of hair are combed in opposite directions | synonyms=parting | examples=his part was right in the middle
11. sense_key=part%1:04:01:: | definition=the actions and activities assigned to or required or expected of a person or group | synonyms=function, office, role | examples=the function of a teacher; the government must do its part
12. sense_key=part%1:09:02:: | definition=that which concerns a person with regard to a particular role or situation | examples=it requires vigilance on our part; they resisted every effort on his part

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
**Analyzing the Sense of "Parts" in a Medical Context**

Okay, so I'm looking at the word "parts" in the phrase "other parts of the body," and I need to determine the best sense of this word, given it's medical. My initial thought is to identify which sense best captures the spatial aspect of cancer spreading.

I start by considering some candidate senses. First, there's "region," which is an extended spatial location. Then there's "piece," meaning a portion of a natural object, which a body could be, though not the usual sense when talking about "other parts of the body." Then there's "component" or "constituent," a part in relation to the whole.

Given that cancer "spreads to" other "parts" of the body, I'm leaning toward spatial concepts. Let's dig deeper: I need to check WordNet. I search for "parts of the body". Is "body part" itself a distinct synset? Yes, it is. But the target lemma is "part." If "body part" isn't a direct option, which sense of "part" applies?

Let's look at Candidate 2: "the extended spatial location of something" – synonyms include "region." Aha! "Other parts of the body" seems to mean "other locations in the body." I immediately think of examples like "religions in all parts of the world" which parallels my target phrase.

Now, I revisit Candidate 6, "something determined in relation to something that includes it," which is like a component or constituent. This isn't quite right for the movement implied by cancer spreading. But, for that to be the right candidate the lemma would need to be "body part".

I'm thinking now, I should consider the example of the phrase in medical texts, to determine if I'm being precise. I note that medical texts often use "regions of the body." I know in practice, a body part is more like an organ or limb. So, the concept of "location" is crucial here. The word "spread" requires a destination.

I keep coming back to Candidate 2: spatial region. It has "religions in all parts of the world" - this fits my medical phrase exactly: the analogy is obvious. Regions, regions, regions.

I check Candidate 7 again: "a portion of a natural object" but I'm focusing on "a location". This seems like dividing a river up, or breaking a rock into pieces. Definitely not it.

So, I'm seeing it this way: with the "spread to" implies movement to a spatial location.
So my selection is Candidate 2: a region.
I need to check WordNet dict again. Yes, "region" has the sense "a part of an animal that has a special function or is supplied by a given nerve or blood vessel" (e.g., abdominal region).

I think, the best choice is "region".

I'm leaning towards Candidate 2 (region). I can see it. If something spreads to another 'part of the body', it spreads to another region. Therefore, I pick sense 2. "regions" or locations.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: body
Target surface form: body
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the <t>body</t>), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=body%1:08:02:: | definition=a natural object consisting of a dead animal or person | synonyms=dead body | examples=they found the body in the lake
2. sense_key=body%1:06:01:: | definition=a resonating chamber in a musical instrument (as the body of a violin) | synonyms=soundbox
3. sense_key=body%1:10:00:: | definition=the central message of a communication | examples=the body of the message was short
4. sense_key=body%1:07:00:: | definition=the property of holding together and retaining its shape | synonyms=consistency, consistence, eubstance | examples=wool has more body than rayon; when the dough has enough consistency it is ready to bake
5. sense_key=body%1:07:01:: | definition=the main mass of a thing
6. sense_key=body%1:14:02:: | definition=a collection of particulars considered as a system | examples=a body of law; a body of doctrine
7. sense_key=body%1:14:00:: | definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium; the student body
8. sense_key=body%1:17:00:: | definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
9. sense_key=body%1:06:00:: | definition=the external structure of a vehicle | examples=the body of the car was badly rusted
10. sense_key=body%1:08:01:: | definition=the body excluding the head and neck and limbs | synonyms=torso, trunk | examples=they moved their arms and legs and bodies
11. sense_key=body%1:08:00:: | definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 11}
```

content:
```json
{"sense_index": 11}
```

reasoning_content:
**Analyzing "Body" in the Context of Metastatic Cancer**

Okay, so the target is the word "body" within the phrase "to other parts of the body." My expertise immediately flags this as a medical context, specifically related to cancer metastasis – that's the spread of cancer from its original site. I need to figure out which definition of "body" is most relevant here.

Let's quickly run through the candidates. "Dead body" is obviously incorrect. "Resonating chamber," "central message," "consistency," "main mass," "collection of particulars," "group of persons," and "vehicle structure" don't fit the context of cancer spreading to *other parts*. "Torso/trunk" narrows it down a bit, but isn't complete, and "3-dimensional object" is too general to be useful here.

That leaves us with the final candidate: "the entire structure of an organism (an animal, plant, or human being)," essentially the complete physical structure. The synonyms provided – "organic structure," "physical structure" – are spot on. And the example sentence, "he felt as if his whole body were on fire," further cements that this is about the complete physical form of the organism.

Therefore, the only reasonable interpretation of "other parts of the body" in this medical context is a reference to the human physical structure as a whole. Cancer spreads to *other parts of the entire body*. Simple.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in <t>patients</t> who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role
2. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
**Analyzing the Word "Patients" in Context**

Okay, so I'm looking at "patients," specifically the plural form, and the task is to pinpoint the correct sense based on the surrounding text. The context mentions Alimta, a medical treatment, and the phrase "in patients who have not received chemotherapy." My initial thought is to consider the possible meanings – the first being the semantic role of the patient, the one acted upon, and the second, a person needing medical attention.

Given the clinical nature of Alimta and the mention of chemotherapy, the second sense, the one referring to individuals under medical care, is undeniably the best fit. There's no ambiguity here. The sentence isn't about the *role* someone plays, but about the *people* receiving treatment. The context is perfectly aligned with the definition of a person needing medical care. Case closed.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicines
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (<t>medicines</t> for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
**Analyzing the Nuances of "Medicines" in Context**

Okay, so the target term is "medicine," but the surface form is "medicines" – that's the first thing to note. The surrounding text, though, centers on "chemotherapy (medicines for cancer)." Immediately, my mind flags this as a substance utilized in the treatment of cancer. This context is critical, as it narrows down the possible senses.

Now, let's look at the definitions. Sense 2, specifically, nails it: "(medicine) something that treats or prevents or alleviates the symptoms of disease." The provided synonyms – medication, medicament, medicinal drug – are dead-on. They resonate perfectly with the idea of chemotherapy agents. This is a clear match; it’s the appropriate sense to use here, and I index it as 2. Done.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for <t>cancer</t>) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
2. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
5. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 4}
```

content:
```json
{"sense_index": 4}
```

reasoning_content:
**Analyzing the Word "Cancer" in Context**

Okay, so the prompt gives me "cancer," specifically in the phrase "chemotherapy (medicines for cancer)." Immediately, my mind goes to the medical definition. I need to be precise, and I see that Sense 4 of the word aligns perfectly. This is the malignant neoplastic disease – the uncontrolled cell division, the tumor that can spread, the whole picture.

Let's quickly rule out the other senses. We're not talking about astrology or constellations (Senses 1, 3, and 5). And definitely not the genus *Cancer* (Sense 2, the crabs). Those are distractions. Chemotherapy deals with a disease, and Sense 4 precisely describes that disease: "any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream." Bingo. That's the one. My brain is happy; we can proceed.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: advanced
Target surface form: advanced
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before <t>advanced</t> or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=advanced%5:00:00:late:00 | definition=far along in time | synonyms=ripe | examples=a man of advanced age; advanced in years
2. sense_key=advanced%5:00:00:progressive:01 | definition=ahead of the times | synonyms=forward-looking, innovative, modern | examples=the advanced teaching methods; had advanced views on the subject
3. sense_key=advanced%5:00:02:high:02 | definition=at a higher level in training or knowledge or skill | examples=an advanced degree; an advanced text in physics
4. sense_key=advanced%5:00:00:front:00 | definition=situated ahead or going before | synonyms=advance, in advance | examples=an advance party; at that time the most advanced outpost was still east of the Rockies
5. sense_key=advanced%5:00:00:civilized:00 | definition=(of societies) highly developed especially in technology or industry | examples=advanced societies; an advanced country technologically
6. sense_key=advanced%5:00:00:high-tech:00 | definition=ahead in development; complex or intricate | synonyms=sophisticated | examples=advanced technology; a sophisticated electronic control system
7. sense_key=advanced%5:00:00:late:02 | definition=comparatively late in a course of development | examples=the illness had reached an advanced stage; an advanced state of exhaustion
8. sense_key=advanced%5:00:00:precocious:00 | definition=farther along in physical or mental development | examples=the child's skeletal age was classified as `advanced'; children in the advanced classes in elementary school read far above grade average

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 7}
```

content:
```json
{"sense_index": 7}
```

reasoning_content:
**Analyzing "Advanced" in the Context of Lung Cancer**

Okay, here's what I'm thinking. The key word is "advanced" as it relates to "advanced or metastatic non-small cell lung cancer." Clearly, we're talking about the *stage* of the disease. I need to be precise, so I started considering potential senses of "advanced" to make sure I'm zeroing in on the right one. I had a few possibilities floating around in my head: "far along in time" like with age, something "ahead of its time" like a teaching method, "at a higher level" as in training, or perhaps something "going before," highly developed societies, or something "high-tech" as in an advanced machine.

Then it hits me, and it clicks into place. There's a perfect fit! The sense that nails it is the "late" meaning, number 7 on my mental list. It's defined as "comparatively late in a course of development." Bingo! The examples given, "the illness had reached an advanced stage," are spot-on.

Just to be absolutely sure, I'm going to double-check against the context: "advanced or metastatic non-small cell lung cancer." Yep, it still aligns perfectly. This is sense "advanced%5:00:00:late:02" with the definition "comparatively late in a course of development" and the example "the illness had reached an advanced stage." Nailed it. This is exactly what we're looking for, in this context.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cell
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small <t>cell</t> lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell
5. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
**My Analysis of "Cell" in Context**

Okay, so the target word is "cell." The context, "advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells," immediately screams biology to me. No question about it; we're dealing with the biological meaning of "cell." Let's confirm with the definition: "the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals." Yep, spot on. Covers everything from single-celled organisms to complex multicellular structures. The index number, 7, likely just refers to the definition's location. This context is straightforward. Moving on.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: affect
Target surface form: affecting
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not <t>affecting</t> the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=affect%2:42:00:: | definition=connect closely and often incriminatingly | synonyms=involve, regard | examples=This new ruling affects your business
2. sense_key=affect%2:30:00:: | definition=have an effect upon | synonyms=impact, bear upon, bear on, touch on, touch | examples=Will the new rules affect me?
3. sense_key=affect%2:37:00:: | definition=have an emotional or cognitive impact upon | synonyms=impress, move, strike | examples=This child impressed me as unusually mature; This behavior struck me as odd
4. sense_key=affect%2:32:00:: | definition=make believe with the intent to deceive | synonyms=feign, sham, pretend, dissemble | examples=He feigned that he was ill; He shammed a headache
5. sense_key=affect%2:29:00:: | definition=act physically on; have an effect upon | examples=the medicine affects my heart rate

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{
  "sense_index": 5
}
```

content:
```json
{
  "sense_index": 5
}
```

reasoning_content:
**Analyzing the Meaning of "Affecting" in a Medical Context**

Okay, the target word is "affecting" in the phrase "...not affecting the squamous cells," within the context of non-small cell lung cancer. My initial thought is that it's referring to the cancer physically acting upon or having an impact on those cells. The disease isn't *involving* or *touching* those cells in some active way.

Let's dive into the nuances of "affect." I've got a few candidate senses from WordNet to consider. First, there's "connect closely and often incriminatingly" (involve, regard). That doesn't fit here. Next, "have an effect upon" (impact, bear upon). Then, we have "have an emotional or cognitive impact upon" (impress, move, strike) - that's definitely not it. There's also the deceptive "make believe." Nope. And finally, there's the one that seems most promising: "act physically on; have an effect upon." That's the one with the example of "the medicine affects my heart rate."

Given the medical context, I'm leaning heavily towards the "act physically on" sense, specifically *sense 5*. It's almost always related to biological or physical processes.

To be extra certain, I need to confirm whether the usage is consistent with WordNet's definition and standard examples. So, let me check the exact WordNet gloss for *affect%2:29:00::*. It states, "act physically on; have an effect upon," which fits perfectly. "The medicine affects my heart rate" is a great example. Cancer, in this scenario, would be acting physically on the cells, or involving them directly. Let's see... what about the relationship to disease? Yes, *affect%2:29:00::* falls under the verb.body domain. This is solidifying the interpretation here.

Let's also look at the other candidate senses just to be thorough. *Affect%2:30:00::* is verb.change, and *affect%2:42:00::* is verb.stative. These clearly do not fit here.

So, in the context, "cancer that is not affecting the squamous cells" means the cancer is *not* acting physically on those cells. The verb.body sense is the most relevant. The disease is *not* having a direct, physical effect on them. It's sense 5. I'm confident.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: used
Context:
Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is <t>used</t> in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription.

Candidate senses:
1. sense_key=use%2:34:02:: | definition=take or consume (regularly or habitually) | synonyms=habituate | examples=She uses drugs rarely
2. sense_key=use%2:41:03:: | definition=habitually do something (use only in the past tense) | examples=She used to call her mother every week but now she calls only occasionally; I used to get sick when I ate in that dining hall
3. sense_key=use%2:34:00:: | definition=use up, consume fully | synonyms=expend | examples=The legislature expended its time on school questions
4. sense_key=use%2:41:04:: | definition=avail oneself to | synonyms=practice, apply | examples=apply a principle; practice a religion
5. sense_key=use%2:34:01:: | definition=put into service; make work or employ for a particular purpose or for its inherent or natural purpose | synonyms=utilize, utilise, apply, employ | examples=use your head!; we only use Spanish at home
6. sense_key=use%2:41:14:: | definition=seek or achieve an end by using to one's advantage | examples=She uses her influential friends to get jobs; The president's wife used her good connections

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 5}
```

content:
```json
{"sense_index": 5}
```

reasoning_content:
**Analyzing the Meaning of "Used" in a Medical Context**

Okay, the target word is "used," and the lemma is "use." The context is about Alimta being *used* in combination with cisplatin for cancer treatment. My initial thought is that "used" here refers to employing the medicine for its intended purpose—treatment.

Let's quickly go through the possible senses. "She uses drugs rarely" - no, it's not the patient's usage, but the drug's application. "Use up, consume fully" and "avail oneself to" don't fit either. Then there's sense 5: "put into service; make work or employ for a particular purpose or for its inherent or natural purpose." That's the one! It's about utilizing something, like "use your head!" or "we only use Spanish at home".

Perfect, Alimta is *put into service* / *employed* in the treatment, in combination with another agent. It aligns perfectly with sense 5. I'll quickly double-check for any medical-specific meanings, but I don't see any overriding definition.

Therefore, sense 5, the standard meaning of applying something for a purpose, is the right one. The context reinforces that; Alimta is *used* to treat patients with cancer.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in <t>patients</t> who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
**Analyzing the Meaning of "Patients"**

Okay, so I've been given the word "patients" within the phrase "Alimta is used in combination with cisplatin in patients who have not been treated before...". My immediate task is to pinpoint the most appropriate sense of "patients" in this specific context. I'm already thinking about it in terms of its lemma, which is "patient".

Looking at the likely candidate senses, I have:

1.  a person who requires medical care
2.  the semantic role of an entity...

Based on the context – the mention of "Alimta" and "cisplatin," both well-known chemotherapy drugs – it's absolutely evident that we're talking about individuals undergoing medical treatment. The second sense, referring to a semantic role, is clearly irrelevant here. Therefore, sense number one, "a person who requires medical care," is the correct interpretation. It's that straightforward.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: treat
Target surface form: treated
Context:
Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been <t>treated</t> before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription.

Candidate senses:
1. sense_key=treat%2:31:00:: | definition=regard or consider in a specific way | examples=I treated his advances as a joke
2. sense_key=treat%2:29:00:: | definition=provide treatment for | synonyms=care for | examples=The doctor treated my broken leg; The nurses cared for the bomb victims
3. sense_key=treat%2:32:00:: | definition=act on verbally or in some form of artistic expression | synonyms=cover, handle, plow, deal, address | examples=This book deals with incest; The course covered all of Western Civilization
4. sense_key=treat%2:40:00:: | definition=provide with a gift or entertainment | examples=Grandmother always treated us to the circus; I like to treat myself to a day at a spa when I am depressed
5. sense_key=treat%2:41:00:: | definition=interact in a certain way | synonyms=handle, do by | examples=Do right by her; Treat him with caution, please
6. sense_key=treat%2:34:00:: | definition=provide with choice or abundant food or drink | synonyms=regale | examples=Don't worry about the expensive wine--I'm treating; She treated her houseguests with good food every night
7. sense_key=treat%2:32:03:: | definition=engage in negotiations in order to reach an agreement | examples=they had to treat with the King
8. sense_key=treat%2:30:01:: | definition=subject to a process or treatment, with the aim of readying for some purpose, improving, or remedying a condition | synonyms=process | examples=process cheese; process hair

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
**Analyzing the Meaning of "Treated" in Medical Context**

Okay, so the target word is "treated," and it's used in the sentence about Alimta combined with cisplatin, specifically for patients "who have not been treated before." Immediately, the medical context screams out at me. We're talking about a medicine, a treatment for cancer, so that narrows things down considerably.

Let's look at the candidate senses. I'm already dismissing most of these as irrelevant. Treating someone with regard, acting verbally, providing a gift or food, interacting, or negotiating—none of those apply here. I'm focused on the definitions related to actions performed *on* a person to affect a change, specifically in a medical context.

That brings me to sense 2: "treat%2:29:00:: provide treatment for." "Patients who have not been treated before"—that's the key phrase. It's clearly referring to patients who haven't received *medical* treatment previously. This sense fits perfectly. Providing treatment is *exactly* what's being implied. So, sense 2 is the clear winner here.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in <t>patients</t> who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Use of "Patients" in Context**

Okay, so the lemma I'm working with is "patient," and the surface form is "patients." The context is from a medical text discussing Alimta. The text states, "...on its own in patients who have received another type of chemotherapy in the past." This is pretty straightforward. It's unequivocally referring to individuals undergoing medical treatment. There's no room for ambiguity here, as would be the case in an abstract discussion.

My knowledge base tells me that "patient" has a couple of distinct senses. The first, and clearly relevant here, is a person receiving medical care. The second has to do with semantic roles, where the "patient" is the entity being acted upon, but this clearly is not the case here.

Therefore, the only applicable sense of "patient" in this context is Sense 1: a person who requires medical care. We will choose that.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: type
Target surface form: type
Context:
Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another <t>type</t> of chemotherapy in the past. The medicine can only be obtained with a prescription.

Candidate senses:
1. sense_key=type%1:10:00:: | definition=all of the tokens of the same symbol | examples=the word `element' contains five different types of character
2. sense_key=type%1:09:00:: | definition=a subdivision of a particular kind of thing | examples=what type of sculpture do you prefer?
3. sense_key=type%1:10:01:: | definition=printed characters | examples=small type is hard to read
4. sense_key=type%1:18:00:: | definition=a person of a specified kind (usually with many eccentricities) | synonyms=character, eccentric, case | examples=a real character; a strange character
5. sense_key=type%1:06:00:: | definition=a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper | examples=he dropped a case of type, so they made him pick them up
6. sense_key=type%1:14:01:: | definition=(biology) the taxonomic group whose characteristics are used to define the next higher taxon

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
**Analyzing "Type" in a Medical Context**

Okay, so the task is to pinpoint the correct sense of "type" in the phrase "...another type of chemotherapy in the past." Right off the bat, I need to assess the different potential meanings. Let's run through the candidates: first, the one about linguistic symbols - clearly not relevant here. Next, we have the broader "subdivision of a kind" – sounds promising; then the typography sense (printed characters), a person with particular characteristics, the physical blocks of type, and finally the biological taxonomic meaning.

Now, considering the medical context of chemotherapy, it's pretty clear that we're talking about *different kinds* or *categories* of treatment. The phrase implies a distinction between various approaches to chemotherapy. That perfectly aligns with sense index 2: "a subdivision of a particular kind of thing." Like asking "what type of sculpture?" We're asking "what type of chemotherapy?"

The other senses are easily eliminated: tokens and symbols, typography, a particular kind of person, the physical blocks, and a biological classification. So, sense index 2, is the definitive winner. It’s a straightforward disambiguation.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: past
Target surface form: past
Context:
Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the <t>past</t>. The medicine can only be obtained with a prescription.

Candidate senses:
1. sense_key=past%1:10:00:: | definition=a verb tense that expresses actions or states in the past | synonyms=past tense
2. sense_key=past%1:28:00:: | definition=the time that has elapsed | synonyms=past times, yesteryear | examples=forget the past
3. sense_key=past%1:28:01:: | definition=a earlier period in someone's life (especially one that they have reason to keep secret) | examples=reporters dug into the candidate's past

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
**My Analysis of "Past" in Context**

Okay, so the lemma is "past," and the surface form is, well, "past." The context is "...patients who have received another type of chemotherapy in the past." Right off the bat, I need to consider the possible senses: verb tense, the time that has elapsed, or an earlier period in someone's life.

In this specific instance, "in the past" clearly refers to the time that has already gone by, meaning "previously." It's not about some secret history that was uncovered, so that's out. And it's definitely not about grammatical tense. So, my initial thought leans towards sense 2, "the time that has elapsed," which has synonyms like "past times" and "yesteryear." The example provided – "forget the past" – feels relevant here.

Hmm, but wait... "in the past" really just boils down to meaning "previously." So "the time that has elapsed" does capture the idea of a period before the present, before the given moment.

Let me just double-check, compare sense 2 and sense 3 more carefully. Thinking about it in the provided context, "in patients who have received another type of chemotherapy in the past" means in the time before, or at a previous time. So, that further reinforces sense 2. It’s the standard temporal sense.

Therefore, the correct index is 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The <t>medicine</t> can only be obtained with a prescription. How is Alimta used?

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
3. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine
4. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
**Analyzing the Term "Medicine"**

Okay, so the target word here is "medicine," used within the phrase "The medicine can only be obtained with a prescription." Right away, the context is clear – we're talking about a treatment. Let's break this down systematically.

My initial thought, given the sentence, is that we're dealing with Sense 4: something that treats or prevents or alleviates disease, like a medication or a medicinal drug. The synonyms offered – medication, medicament, medicinal drug – all align perfectly with the clinical and practical use of the word in this context.

Now, let's briefly consider the other senses. Sense 1, referring to the branches of medical science, is clearly irrelevant here. The sentence isn't about medical fields, but a specific substance. Sense 2, the learned profession, and sense 3, referring to punishment, are equally inappropriate. It's a blatant misinterpretation of the text.

Therefore, with absolute certainty and given my expertise, Sense 4 is the only logical interpretation. The context, the synonyms, and the everyday understanding of the word all point directly to a medicinal treatment.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: only
Target surface form: only
Context:
It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can <t>only</t> be obtained with a prescription. How is Alimta used?

Candidate senses:
1. sense_key=only%4:02:03:: | definition=never except when | synonyms=only if, only when | examples=call me only if your cold gets worse
2. sense_key=only%4:02:06:: | definition=except that | examples=It was the same story; only this time she came out better
3. sense_key=only%4:02:05:: | definition=as recently as | examples=I spoke to him only an hour ago
4. sense_key=only%4:02:04:: | definition=in the final outcome | examples=These news will only make you more upset
5. sense_key=only%4:02:01:: | definition=without any others being included or involved | synonyms=entirely, exclusively, solely, alone | examples=was entirely to blame; a school devoted entirely to the needs of problem children
6. sense_key=only%4:02:02:: | definition=and nothing more | synonyms=merely, simply, just, but | examples=I was merely asking; it is simply a matter of time
7. sense_key=only%4:02:00:: | definition=with nevertheless the final result | examples=He arrived only to find his wife dead; We won only to lose again in the next round

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 5}
```

reasoning_content:
**Deconstructing the Word "Only"**

Okay, so the target is the word "only" in the sentence "The medicine can only be obtained with a prescription." Right, let's break this down. My initial thought is to consider the possible senses of "only." I'm mentally running through the candidates: is it "never except when," "except that," "as recently as," "in the final outcome," "without any others being included or involved," "and nothing more," or "with nevertheless the final result"?

Initially, my brain jumped to "without any others being included or involved," the sense that encompasses "exclusively," "solely," and "alone." So, I was thinking, "The medicine can exclusively/solely be obtained with a prescription." But then, I paused. Could it be "only if?" The sentence, "The medicine can be obtained only with a prescription" – does that translate to "never except when?" No, a prescription isn't a "when" or "if" clause.

Let's circle back to that fifth sense, "without any others being included or involved." Thinking out loud, "The medicine can solely be obtained with a prescription." That feels right. Then I briefly entertained the idea of "and nothing more," but that doesn't fit the context.

I'm now zeroing in on "entirely, exclusively, solely, alone." "The medicine can solely be obtained with a prescription," and then I reconsidered, thinking it could also be sense one: "only if, only when."

But, let's solidify the fifth sense and see if it fits. The definition is "without any others being included or involved," and the synonyms are "entirely, exclusively, solely, alone." I'm checking it again: "The medicine can solely be obtained with a prescription." That works.

Let me verify it further, I consulted WordNet and review the senses to reinforce. The key here seems to be that exclusive, sole means – “without any others being included or involved.” It's a match. I’m confident that it corresponds to the meaning. It is definitely sense 5, a match.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: obtain
Target surface form: obtained
Context:
It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be <t>obtained</t> with a prescription. How is Alimta used?

Candidate senses:
1. sense_key=obtain%2:42:00:: | definition=be valid, applicable, or true | synonyms=prevail, hold | examples=This theory still holds
2. sense_key=obtain%2:40:00:: | definition=come into possession of | examples=How did you obtain the visa?
3. sense_key=obtain%2:30:00:: | definition=receive a specified treatment (abstract) | synonyms=receive, get, find, incur | examples=These aspects of civilization do not find expression or receive an interpretation; His movie received a good review

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
**Analyzing the Usage of "Obtained"**

Alright, let's break this down. The target word is "obtain," and the specific form we're looking at is "obtained." The context provided is: "The medicine can only be obtained with a prescription." My task is to determine the correct sense of "obtain" in this sentence.

I've got three candidate senses to consider: "be valid, applicable, or true," "come into possession of," and "receive a specified treatment (abstract)." Given my expertise, I quickly rule out sense one, "be valid, applicable, or true," as this use is intransitive, and wouldn't fit here. The sentence clearly implies the act of *getting* or *acquiring* the medicine. Likewise, sense three, referring to a specific abstract treatment, is out of the running. This doesn't apply to acquiring medicine.

That leaves us with sense two: "come into possession of." Perfect! This definition captures the essence of the context: the medicine is *being acquired* or *received*. They are obtaining it. The example given, "How did you obtain the visa?" is spot on. The question is asking how one gained possession of something. This is a very clear match.

Therefore, sense two, "come into possession of," is definitively the correct sense of "obtained" in this sentence. Case closed.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: prescription
Target surface form: prescription
Context:
It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a <t>prescription</t>. How is Alimta used?

Candidate senses:
1. sense_key=prescription%1:10:00:: | definition=directions prescribed beforehand; the action of prescribing authoritative rules or directions | examples=I tried to follow her prescription for success
2. sense_key=prescription%1:10:02:: | definition=written instructions for an optician on the lenses for a given person
3. sense_key=prescription%1:10:01:: | definition=written instructions from a physician or dentist to a druggist concerning the form and dosage of a drug to be issued to a given patient
4. sense_key=prescription%1:06:00:: | definition=a drug that is available only with written instructions from a doctor or dentist to a pharmacist | synonyms=prescription drug, prescription medicine, ethical drug | examples=he told the doctor that he had been taking his prescription regularly

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 3}
```

content:
```json
{"sense_index": 3}
```

reasoning_content:
**Analyzing the "Prescription" Context**

Okay, so the target is "prescription" and the surface form is, well, "prescription." Straightforward enough. The sentence gives us: "The medicine can only be obtained with a prescription." Right away, I'm thinking about the different senses. We've got a few: the act of prescribing (that's sense 1), an optician's prescription (sense 2), the actual written instructions from a doctor (sense 3), and then the drug itself that requires a prescription (sense 4).

Now, considering "obtained with a prescription," the key is that we're getting medicine. Sense 4, the drug *itself*, is the tricky one. But the sentence is saying the *medicine* is "obtained *with* a [something]". It isn't saying the *prescription itself* is being obtained, therefore, sense 4 is out. My instinct says that "obtained *with* a [written instruction]" means that we're dealing with the doctor's order, the written document needed to get the medication.

Bingo. Sense 3, the doctor's written instructions to the pharmacist, feels like the perfect fit. It's the mechanism, the necessary step, to getting the medicine. Sense 3 is the clear winner here.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: used
Context:
What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta <t>used</t>? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy.

Candidate senses:
1. sense_key=use%2:34:02:: | definition=take or consume (regularly or habitually) | synonyms=habituate | examples=She uses drugs rarely
2. sense_key=use%2:41:03:: | definition=habitually do something (use only in the past tense) | examples=She used to call her mother every week but now she calls only occasionally; I used to get sick when I ate in that dining hall
3. sense_key=use%2:41:14:: | definition=seek or achieve an end by using to one's advantage | examples=She uses her influential friends to get jobs; The president's wife used her good connections
4. sense_key=use%2:41:04:: | definition=avail oneself to | synonyms=practice, apply | examples=apply a principle; practice a religion
5. sense_key=use%2:34:01:: | definition=put into service; make work or employ for a particular purpose or for its inherent or natural purpose | synonyms=utilize, utilise, apply, employ | examples=use your head!; we only use Spanish at home
6. sense_key=use%2:34:00:: | definition=use up, consume fully | synonyms=expend | examples=The legislature expended its time on school questions

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 5}
```

reasoning_content:
**Analyzing the Sense of "Used" in a Medical Context**

Okay, the lemma is "use," and the surface form is "used," which immediately suggests a past participle. The context is "How is Alimta used?" and "Alimta should only be given under the supervision...". My initial thought is to figure out the specific sense of "used" in this medical application.

Based on the surrounding context of the medical term, "Alimta," it clearly refers to how the drug is administered or employed. I'm considering several potential senses of "use": habituate, habitually do something, seek an end by advantage, avail oneself, put into service, or consume.

The fifth sense, "put into service; make work or employ for a particular purpose or for its inherent or natural purpose," feels like the best fit here. It's the most general and directly related to applying a tool or medicine to its intended function.

Let me just double-check. Could "use" mean "consume" in this medical setting? Sense 1, "take or consume regularly or habitually," has some overlap, especially in drug contexts, but here it's about administering the drug to the patient rather than the drug "consuming" anything itself. It's more of a passive construction – "How is Alimta used?" means "How is it employed?" So sense 5 seems most appropriate.

The subsequent sentence, "Alimta is used to treat...", reinforces this. It indicates that the drug is *employed* or *utilized* for its intended purpose. If I substitute synonyms for the fifth sense, that confirms my interpretation: "apply, employ, utilize."

Looking at the other senses, let's look at habituation. "She uses drugs rarely" would be an example; it still doesn't apply to the context of administration here.

Therefore, my conclusion is that sense 5, "put into service; make work or employ for a particular purpose," is the correct interpretation in this context.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: only
Target surface form: only
Context:
Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should <t>only</t> be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight).

Candidate senses:
1. sense_key=only%4:02:05:: | definition=as recently as | examples=I spoke to him only an hour ago
2. sense_key=only%4:02:01:: | definition=without any others being included or involved | synonyms=entirely, exclusively, solely, alone | examples=was entirely to blame; a school devoted entirely to the needs of problem children
3. sense_key=only%4:02:00:: | definition=with nevertheless the final result | examples=He arrived only to find his wife dead; We won only to lose again in the next round
4. sense_key=only%4:02:06:: | definition=except that | examples=It was the same story; only this time she came out better
5. sense_key=only%4:02:04:: | definition=in the final outcome | examples=These news will only make you more upset
6. sense_key=only%4:02:03:: | definition=never except when | synonyms=only if, only when | examples=call me only if your cold gets worse
7. sense_key=only%4:02:02:: | definition=and nothing more | synonyms=merely, simply, just, but | examples=I was merely asking; it is simply a matter of time

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
**Analyzing the Ambiguity of "Only"**

Okay, so I'm looking at the word "only" in this sentence: "Alimta should *only* be given under the supervision of a doctor..." My initial thought is to figure out the best sense of "only" here. I've got a list of candidate senses, and I need to figure out which one fits.

First, I consider sense 6, "never except when," which translates to "only if" or "only when." I try, "Alimta should never be given except when under the supervision..." and while grammatically correct, it feels a little clunky. And also "only be given under the supervision" sounds like "only when." Then I have an epiphany: "only be given under..." means "be given exclusively under..."

My next thought is to try sense 2, which means "without any others being included or involved" – synonyms like "entirely," "exclusively," or "solely." I rephrase: "Alimta should solely be given under..." Yes, that really seems to work. The "only" modifies the prepositional phrase "under the supervision", and it's communicating "in no other circumstances" - the meaning of "exclusively."

I check some of the other senses. Sense 2 sounds similar to "a school devoted entirely to the needs of problem children." Sense 6 is like "call me only if your cold gets worse." Sense 7, "and nothing more" (merely, simply), doesn't quite apply here.

Okay, let's look at it like this: If I replace "only" with "exclusively", it still makes sense. "Alimta should exclusively be given under..." Same with "solely."

Now, I keep coming back to sense 6, that "never except when" idea, which is kind of similar. But that usage needs to be with clauses. "Alimta should be given never except when under the supervision..." Doesn't sound right.

I check WordNet, and, based on the examples in WordNet: "a privilege granted only to him", which is like "given only under the supervision."

I confirm:

Sense 2 (exclusively, solely, alone, entirely)
or
Sense 6 (only if, only when)

I think Sense 2 is better. It aligns structurally, modifying a prepositional phrase, and semantically, it's conveying the meaning I want: this should happen and nothing else. Since we have "under the supervision", I think sense 2 makes the most sense.

So, I'm going with sense 2: "exclusively," "solely." That's the best fit here. It's about a *specific* condition being the *only* condition.