[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: use
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for <t>use</t> in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=use%1:04:01:: | definition=(psychology) an automatic pattern of behavior in reaction to a specific situation; may be inherited or acquired through frequent repetition | synonyms=habit | examples=owls have nocturnal habits; she had a habit twirling the ends of her hair
2. sense_key=use%1:22:00:: | definition=(economics) the utilization of economic goods to satisfy needs or in manufacturing | synonyms=consumption, economic consumption, usance, use of goods and services | examples=the consumption of energy has increased steadily
3. sense_key=use%1:07:00:: | definition=what something is used for | synonyms=function, purpose, role | examples=the function of an auger is to bore holes; ballet is beautiful but what use is it?
4. sense_key=use%1:04:02:: | definition=exerting shrewd or devious influence especially for one's own advantage | synonyms=manipulation | examples=his manipulation of his friends was scandalous
5. sense_key=use%1:07:03:: | definition=(law) the exercise of the legal right to enjoy the benefits of owning property | synonyms=enjoyment | examples=we were given the use of his boat
6. sense_key=use%1:04:00:: | definition=the act of using | synonyms=usage, utilization, utilisation, employment, exercise | examples=he warned against the use of narcotic drugs; skilled in the utilization of computers
7. sense_key=use%1:07:02:: | definition=a particular service | examples=he put his knowledge to good use; patrons have their uses

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 6}
```

content:
```json
{"sense_index": 6}
```

reasoning_content:
**Analyzing the Nuances of "Use" in a Clinical Context**

Okay, so I'm presented with "use" in the sentence "Alimta is not recommended for use in patients with moderate or severe kidney problems." My initial task is to pin down the precise meaning of "use" here, because, as we all know, a word as common as "use" can have multiple senses. I've already got a list of potential candidates buzzing around in my head: habit, consumption, function, manipulation, enjoyment, the general act of using, and a specific service.

Given that the surrounding context mentions "use *in patients*", the intended sense must be the *action* of using Alimta. It's not a habit, it's not a particular function, and it’s certainly not enjoyment or manipulation in this context. It's the act of administering or prescribing the drug, in other words the *usage*. The example provided, "he warned against the use of narcotic drugs," is spot on. Therefore, the best sense for "use" is sense 6, meaning the act of utilizing or employing the drug Alimta, and the text I'm reading confirms that it is the precise meaning I am looking for.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in <t>patients</t> with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

finish_reason: stop

content:
```json
{"sense_index": 1}
```

role: assistant

reasoning_content:
**Analyzing the Alimta Usage Context**

Okay, so I'm looking at this information about Alimta, a medical treatment, and specifically, its application and contraindications. The key phrase here is, "Alimta is not recommended for use in patients with moderate or severe kidney problems." My immediate task is to identify the precise meaning of "patients" in this context.

Given the subject matter, the only logical interpretation is the most straightforward: **patient%1:18:00::**, which is a *person who requires medical care*. The alternative sense, **patient%1:10:00::** which might relate to a semantic role, is clearly incorrect. It's a fundamental understanding, but it is necessary to be precise, especially when dealing with medical contexts. There's no ambiguity here; it's a person seeking or receiving medical attention. The implication, then, is that Alimta presents a risk for individuals with compromised kidney function. This is critical information that informs treatment decisions and highlights the need for careful patient assessment.

type: thinking

service_tier: default

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: moderate
Target surface form: moderate
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with <t>moderate</t> or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=moderate%5:00:00:mild:00 | definition=not extreme | synonyms=temperate | examples=a moderate penalty; temperate in his response to criticism
2. sense_key=moderate%3:00:00:: | definition=being within reasonable or average limits; not excessive or extreme | examples=moderate prices; a moderate income
3. sense_key=moderate%5:00:00:temperate:00 | definition=marked by avoidance of extravagance or extremes | synonyms=restrained | examples=moderate in his demands; restrained in his response

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing "Moderate" in a Medical Context**

Okay, so the task is to pinpoint the correct sense of "moderate" in the phrase "...moderate or severe kidney problems." My initial thought is to compare the candidate senses within WordNet.

I see that "moderate" appears in a medical context, specifically with "severe". Let's assess the options: Is it like *not extreme*? Is it like *being within reasonable or average limits*? Is it being *restrained*?

The context suggests a severity scale: mild, moderate, severe. I immediately gravitate towards the first sense, "not extreme". It seems most applicable here.

Diving into WordNet, I find several entries for "moderate". One, with a definition of "not extreme". There's also one that defines it as *being within reasonable or average limits*. And, yet another definition with a sense of *avoidance of extremes*. It's critical to determine if any definition relates to the opposite sense of *severe*.

It seems like WordNet has a specific sense related to contrasting it with *severe*. Let me check the synset associated with "mild". "mild" is the head word. So, "moderate" here is not directly a head word, but rather a satellite of "mild". That makes sense. "Mild", in this context, refers to a "moderate in type or degree or effect or force".

I see in WordNet, that "mild" is defined as moderate in severity. Thus, "moderate" must be referring to the severity scale in medicine, being in contrast to something extreme or severe.

Let's look at the candidates more closely. Candidate 1 is "not extreme". This sounds right. Candidate 2 is "within reasonable limits," like a price. This doesn't seem to fit the medical context.

Thinking further, severe is an antonym to mild. So, if "moderate" is a satellite of "mild", then it's directly along the scale of severity.

Therefore, "moderate" in "moderate kidney problems" *must* be referring to the "not extreme" sense, which is like "mild." This maps to WordNet's definition of "moderate%5:00:00:mild:00".

Now, about the synonyms for this candidate, the WordNet entry provides "temperate". Does "temperate" fit with kidney problems? WordNet groups them, but I need to be sure. "Temperate" usually means being restrained. This still makes sense in the context of disease, as it does refer to being *not extreme*.

Let's check "reasonable or average limits." No, kidney problems are not reasonable, but are measured for severity.

So, I will conclude that candidate 1, the "not extreme" sense, is the correct interpretation.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: severe
Target surface form: severe
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or <t>severe</t> kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=severe%5:00:00:strong:00 | definition=very strong or vigorous | synonyms=hard, knockout | examples=strong winds; a hard left to the chin
2. sense_key=severe%5:00:00:intense:00 | definition=intensely or extremely bad or unpleasant in degree or quality | synonyms=terrible, wicked | examples=severe pain; a severe case of flu
3. sense_key=severe%5:00:00:plain:01 | definition=severely simple | synonyms=austere, stark, stern | examples=a stark interior
4. sense_key=severe%5:00:00:critical:03 | definition=causing fear or anxiety by threatening great harm | synonyms=dangerous, grave, grievous, serious, life-threatening | examples=a dangerous operation; a grave situation
5. sense_key=severe%5:00:01:bad:00 | definition=very bad in degree or extent | examples=a severe worldwide depression; the house suffered severe damage
6. sense_key=severe%5:00:02:nonindulgent:00 | definition=unsparing and uncompromising in discipline or judgment; - H.G.Wells | synonyms=spartan | examples=a parent severe to the pitch of hostility; a hefty six-footer with a rather severe mien

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

content:
```json
{"sense_index": 2}
```

reasoning_content:
**Analyzing the Meaning of "Severe" in a Medical Context**

Okay, so the target is "severe" within the phrase "severe kidney problems." My initial approach is to evaluate the candidates and see which best fits the intended medical context. Candidate 2, with examples like "severe case of flu" and a definition of "intensely or extremely bad or unpleasant in degree or quality", immediately stands out. That's a strong fit. "Severe kidney problems" certainly describes an *intensely bad* medical state.

I'm also considering Candidate 4, which offers "critical" and synonyms like "dangerous" and "life-threatening". That does work, but is it the *best* fit? It leans towards something urgent and possibly immediate, which might not always be the case for "severe kidney problems."

Now, let me make sure. I'm checking WordNet to confirm that "a severe case of flu" is exactly candidate 2. And, yes, the gradation of medical conditions – mild, moderate, severe – points to the appropriate level of "badness". Candidate 2 also has "intensely or extremely bad or unpleasant in degree or quality," which works well for pain, illness, or medical state.

Just to be absolutely sure, I'm taking another look at Candidate 5. "Very bad in degree or extent" fits more general contexts, like "severe worldwide depression" or "severe damage." While "severe kidney problems" *could* fall under that broad umbrella, the "flu" example within Candidate 2 feels more precise. The "flu" example in Candidate 2 perfectly aligns with "kidney problems." The connection is clear.

Okay, so I am confident that sense index 2 is the most appropriate.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: problem
Target surface form: problems
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney <t>problems</t>. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=problem%1:09:00:: | definition=a source of difficulty | synonyms=trouble | examples=one trouble after another delayed the job; what's the problem?
2. sense_key=problem%1:10:00:: | definition=a question raised for consideration or solution | examples=our homework consisted of ten problems to solve
3. sense_key=problem%1:26:00:: | definition=a state of difficulty that needs to be resolved | synonyms=job | examples=she and her husband are having problems; it is always a job to contact him

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{
  "sense_index": 3
}
```

content:
```json
{
  "sense_index": 3
}
```

reasoning_content:
**Analyzing "Kidney Problems" in a Medical Context**

Okay, here's what's running through my head as I parse this text. The phrase "kidney problems" pops up in a medical context related to Alimta dosage. My mind immediately starts dissecting the word "problems." We are talking about "moderate or severe kidney *problems*." So, "problem" here means the kidneys are *not* working properly, right?

I immediately consult my mental lexicon—WordNet, in this case. I consider the nuances of "problem" – is it a *source* of difficulty (like a malfunctioning machine) or a *state* of difficulty that needs resolution? There are several senses of "problem," but the context is key.

My initial instinct is to equate "kidney problems" with "kidney *trouble*." Trouble suggests something is *wrong*, a malfunction. Does "kidney trouble" map onto one of the senses of "problem"? I check.

I think: trouble is a *source* of difficulty, usually. But, wait, "problem" also has a "state of difficulty that needs to be resolved" sense. Health problems are often "trouble". I note that "health problem" is often annotated as "a state of difficulty that needs to be resolved".

Then I check SemCor. The SemCor corpus confirms this: "health problems", "heart problems," etc., all point to this "state of difficulty" sense. Is "kidney problems" a source? No, it's a *state* that *needs resolving*. It's not just a difficult thing to deal with; it's a condition that needs treatment.

So I weigh the two senses. Sense 1, the source of difficulty, vs. Sense 3, a state of difficulty that needs to be resolved. This is where I go deeper:

*   Sense 1 has "trouble" as a synonym. So a "kidney trouble" makes sense, and this is where I initially want to go. However, that isn't quite the best annotation. It is just used to make the process easier.
*   Sense 3 has "job" as a synonym. This seems odd.
    I think about examples: "she and her husband are having problems." Fits well. "Patients *with* kidney problems" - they are "having" them, a *state*. "Financial problems" - a state.

The synsets are useful, the context of the sentence is paramount. I'm focusing on that. I check the hierarchy. Kidney problems are clearly a medical *condition* - a *state*. This points strongly to sense 3: a state of difficulty, not a mere source. The *condition* hierarchy is more fitting.

Looking at the definitions, I'm now clear that "kidney problems" reflects a **state of difficulty**, a medical condition demanding resolution. Sense 3, a state of difficulty is what is being discussed.

Sense 3 is the correct choice structurally, even if "job" is a weird synonym. "job" just happens to be in that synset (e.g., "it is a job to keep this place clean"). But "problem" as a state of difficulty applies to "marital problems", "financial problems", "kidney problems".

Ultimately, the phrase "patients *with* moderate or severe kidney problems" describes the *condition* they have. It's a "state of difficulty" within their bodies. It isn't merely a *source* of difficulty like a machine issue. Therefore, sense 3 (problem%1:26:00) is the better fit, being "a state of difficulty that needs to be resolved."


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: more
Target surface form: more
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For <t>more</t> information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=more%3:00:02:: | definition=(comparative of `many' used with count nouns) quantifier meaning greater in number | examples=a hall with more seats; we have no more bananas
2. sense_key=more%3:00:01:: | definition=(comparative of `much' used with mass nouns) a quantifier meaning greater in size or amount or extent or degree | synonyms=more than | examples=more land; more support

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
**Analyzing the Word "More" in Context**

Okay, so the target word is "more," and the surface form, unsurprisingly, is also "more." The context is "For more information, see the Summary of Product Characteristics..." Now, I need to choose the correct sense from the possibilities. I've got two candidates: the first relates to "many" and deals with countable nouns, while the second relates to "much" and deals with mass nouns.

Ah, "information." That's the key. I know "information" is a mass noun; you can't have "one information" or "two informations," right? Therefore, the "more" in "more information" must be functioning as the comparative of "much." It's referring to a greater amount or degree, not a greater number. That means sense 2 is the correct one: "comparative of 'much' used with mass nouns." Sense 1, which relates to countable nouns and "many," is clearly incorrect here. I'm selecting sense 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: information
Target surface form: information
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more <t>information</t>, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=information%1:10:02:: | definition=formal accusation of a crime
2. sense_key=information%1:10:00:: | definition=a message received and understood | synonyms=info
3. sense_key=information%1:09:00:: | definition=knowledge acquired through study or experience or instruction
4. sense_key=information%1:07:00:: | definition=(communication theory) a numerical measure of the uncertainty of an outcome | synonyms=selective information, entropy | examples=the signal contained thousands of bits of information
5. sense_key=information%1:14:00:: | definition=a collection of facts from which conclusions may be drawn | synonyms=data | examples=statistical data

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
**Analyzing the Nuances of "Information" in Context**

Okay, so the target word here is "information," and the context is "For more information, see the Summary of Product Characteristics..." Immediately, I'm already sifting through the potential senses. My initial instinct, given the phrase, is that it's most likely sense 2: "a message received and understood" – basically, *info*. We're talking about a document, and the goal is clearly to get more details or facts about something, in this case, the drug Alimta. It makes sense, right? "For more *info*..." that aligns with sense 2.

But hold on, let's not jump to conclusions. I need to be precise.  Let's consider the other possibilities.  Sense 3, "knowledge acquired through study," and sense 5, a "collection of facts" (data), are in the running, but seem less likely here. We're not talking about deep learning or raw data. The phrase suggests something readily consumable.

Alright, so the question is *is* "information" referring to a *message* vs. "data"?  "For more *info*" really does seem to cleanly map to sense 2.  I'm thinking about textual information, provided in a document.  I would like to check some WordNet examples, if available, just to be absolutely sure.

I'm checking the definitions: sense 2, information%1:10:00::, is a "message received and understood," and it lists "info" as a synonym. Bingo!  It matches the most common usage of the term "For more information."  Sense 5, information%1:14:00:: is data. So, "For more information" is "For more info" in this case.  It's clear that it's a message received, rather than raw data.

Yes, now looking at WordNet, "info" is indeed a perfect synonym for information%1:10:00::, which is a "message received and understood."  That's the best fit. I'm selecting Sense 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: see
Target surface form: see
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=see%2:41:12:: | definition=go to see for a social visit | examples=I went to see my friend Mary the other day
2. sense_key=see%2:39:02:: | definition=perceive or be contemporaneous with | synonyms=witness, find | examples=We found Republicans winning the offices; You'll see a lot of cheating in this school
3. sense_key=see%2:38:03:: | definition=accompany or escort | synonyms=escort | examples=I'll see you to the door
4. sense_key=see%2:39:03:: | definition=see or watch | synonyms=watch, view, catch, take in | examples=view a show on television; This program will be seen all over the world
5. sense_key=see%2:39:12:: | definition=go or live through | synonyms=experience, go through | examples=We had many trials to go through; he saw action in Viet Nam
6. sense_key=see%2:31:00:: | definition=deem to be | synonyms=consider, reckon, view, regard | examples=She views this quite differently from me; I consider her to be shallow
7. sense_key=see%2:35:09:: | definition=receive as a specified guest | examples=the doctor will see you now; The minister doesn't see anybody before noon
8. sense_key=see%2:39:05:: | definition=see and understand, have a good eye | examples=The artist must first learn to see
9. sense_key=see%2:41:14:: | definition=take charge of or deal with | synonyms=attend, take care, look | examples=Could you see about lunch?; I must attend to this matter
10. sense_key=see%2:39:11:: | definition=observe as if with an eye | examples=The camera saw the burglary and recorded it
11. sense_key=see%2:33:00:: | definition=match or meet | examples=I saw the bet of one of my fellow players
12. sense_key=see%2:41:00:: | definition=date regularly; have a steady relationship with | synonyms=go steady, go out, date | examples=Did you know that she is seeing an older man?; He is dating his former wife again!
13. sense_key=see%2:31:01:: | definition=perceive (an idea or situation) mentally | synonyms=understand, realize, realise | examples=Now I see!; I just can't see your point
14. sense_key=see%2:38:00:: | definition=come together | synonyms=meet, run into, encounter, run across, come across | examples=I'll probably see you at the meeting; How nice to see you again!
15. sense_key=see%2:39:13:: | definition=observe, check out, and look over carefully or inspect | synonyms=examine | examples=The customs agent examined the baggage; I must see your passport before you can enter the country
16. sense_key=see%2:31:02:: | definition=get to know or become aware of, usually accidentally | synonyms=learn, hear, get word, get wind, pick up, find out | examples=I learned that she has two grown-up children; I see that you have been promoted
17. sense_key=see%2:31:03:: | definition=be careful or certain to do something; make certain of something | synonyms=check, insure, see to it, ensure, control, ascertain | examples=He verified that the valves were closed; See that the curtains are closed
18. sense_key=see%2:39:00:: | definition=perceive by sight or have the power to perceive by sight | examples=You have to be a good observer to see all the details; Can you see the bird in that tree?
19. sense_key=see%2:36:00:: | definition=imagine; conceive of; see in one's mind | synonyms=visualize, visualise, envision, project, fancy, figure | examples=I can't see him on horseback!; I can see what will happen
20. sense_key=see%2:41:11:: | definition=go to see for professional or business reasons | examples=You should see a lawyer; We had to see a psychiatrist
21. sense_key=see%2:41:10:: | definition=go to see a place, as for entertainment | synonyms=visit | examples=We went to see the Eiffel Tower in the morning
22. sense_key=see%2:31:13:: | definition=make sense of; assign a meaning to | synonyms=interpret, construe | examples=What message do you see in this letter?; How do you interpret his behavior?
23. sense_key=see%2:31:08:: | definition=deliberate or decide | examples=See whether you can come tomorrow; let's see--which movie should we see tonight?
24. sense_key=see%2:32:00:: | definition=find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, find out, ascertain, watch, learn | examples=I want to see whether she speaks French; See whether it works

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 15}
```

content:
```json
{"sense_index": 15}
```

reasoning_content:
**My Analysis of "See" in Context**

Okay, so I'm being asked to perform Word Sense Disambiguation on the lemma "see" within the phrase "For more information, see the Summary of Product Characteristics...". My immediate thought is, what are the relevant senses here? The task isn't to explicitly list what "refer to" maps to, but let's check for senses like "examine," "check out," or "look over carefully." Initially, I considered "determine with certainty", but that seems unlikely.

Let's dive into the list of candidate senses. I'm considering possibilities like:

*   "examine (observe, check out, and look over carefully or inspect)" - Sense 15, which seems like it *could* fit the context of "see the summary."
*   "perceive by sight" - Sense 18. This one might also be applicable, as it could mean looking at the summary.

I’m also keeping an eye out for any implied meanings, such as "consult," even though it's not explicitly listed. I check if there is another sense, e.g., "consult", but it's not listed.

After reviewing the senses, I'm leaning toward the "examine" sense from WordNet, since I'm interpreting "see" to mean "look at," "examine," and "consult." I ask myself, is there a sense of "consult" in WordNet for "see?" No.

I recognize that the common meaning of "see" in contexts like "see page X" is to "look at", so there is a similarity to "examine". I considered if the sense of "perceive by sight" applied here, as I'm thinking about "For more information, look at the summary."

I have another look, and the WordNet definition for `see%2:39:13::` is "observe, check out, and look over carefully or inspect" (synonyms: examine). Then I read the example provided: "I must see your passport before you can enter the country." This makes sense; "see" is an imperative, meaning "look at," "examine," or "consult." Is there a "consult" sense? No, not for "see".

Then I thought, what about "see" as in "refer to"? Could that be? It's often mapped to "examine" or even "perceive by sight." So then I reviewed whether sense 24: "determine, check, find out" made sense here. It doesn't seem to, as that would apply to "See whether it works". Sense 15 is transitive. "See the Summary" takes a noun phrase.

Then, I'm exploring whether "see" could mean "perceive by sight". Is it purely visual perception? No. "See the summary" implies reading and referring to the document.

So, let's look at sense 15. The example of "I must see your passport" is a good analogy for "see the Summary."

I also checked other candidate senses, but I believe the "examine" sense (15) is the best, as it aligns perfectly with the instruction to "look at", "examine," or "consult" the summary for information. Checking the synonyms, "check out" and "look over carefully" fit perfectly.

I think of the meaning as "For more information, observe, check out, and look over carefully or inspect the Summary...".

Then I review WordNet once more. I am confident that I should pick sense 15 "examine", since "I must see your passport" is the example. This implies "examine the summary".

I did consider the "consult" meaning, but I looked in WordNet, and "see" is not listed as a synonym. Dictionaries may group "refer to" under "perceive by sight" or "examine." Based on all that, I'm settling on the "examine" sense.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: product
Target surface form: Product
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=product%1:06:01:: | definition=commodities offered for sale | synonyms=merchandise, ware | examples=good business depends on having good merchandise; that store offers a variety of products
2. sense_key=product%1:27:00:: | definition=a chemical substance formed as a result of a chemical reaction | examples=a product of lime and nitric acid
3. sense_key=product%1:09:00:: | definition=a quantity obtained by multiplication | synonyms=mathematical product | examples=the product of 2 and 3 is 6
4. sense_key=product%1:14:00:: | definition=the set of elements common to two or more sets | synonyms=intersection, Cartesian product | examples=the set of red hats is the intersection of the set of hats and the set of red things
5. sense_key=product%1:06:00:: | definition=an artifact that has been created by someone or some process | synonyms=production | examples=they improve their product every year; they export most of their agricultural production
6. sense_key=product%1:19:00:: | definition=a consequence of someone's efforts or of a particular set of circumstances | examples=skill is the product of hours of practice; his reaction was the product of hunger and fatigue

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{
  "sense_index": 1
}
```

content:
```json
{
  "sense_index": 1
}
```

reasoning_content:
**Deconstructing "Product" in the SmPC: A Pharmaceutical Perspective**

Okay, so the target here is the word "Product" as it appears in "Summary of Product Characteristics," specifically in the context of the medicine Alimta. My initial thought process is to really nail down the nuance here. A medicine, like Alimta, is either a commodity for sale (merchandise, ware) or an artifact created through a process. Given that we're talking about European pharmaceutical regulatory terminology (the SmPC), that's our key context.

I'm considering these two senses: "commodities offered for sale" and "an artifact that has been created by someone or some process." Now, a *medicinal product* generally fits both, right? It's sold as a commodity *and* it's definitely a product of a manufacturing process. Hmm.

Looking at synonyms, for the first sense it's merchandise and ware. For the second it is production. In a regulatory setting, the medicinal product *is* the commercialized drug. The SmPC describes characteristics of the drug as *marketed*. Therefore "commodity offered for sale" seems to fit. But wait, hold on, it could also be sense 5?

Checking WordNet, sense 1 gives examples like "good business depends on having good merchandise", while sense 5 gives "they improve their product every year". Ok, so a manufactured medicine *is* an artifact, but is it sense 1 or sense 5?

Focusing on the phrase, "Summary of Product Characteristics", *product* usually refers to the specific marketed good. So, a "medicinal product" often maps to sense 1 (commodities) or sense 5. Now, thinking through the senses as they apply here. Is it an artifact *created by some process*? Or merchandise?

I'm thinking, in pharmaceuticals, "product" refers to the specific *preparation* of the drug (e.g., Alimta) that is marketed. This is a commodity offered for sale. So, sense 1? But is there a catch?

Let's look at the WordNet hierarchy. Artifact -> Creation -> Product, production (sense 5) and Commodity, trade good, good (merchandise, ware, product (sense 1)). So product as a pharmaceutical drug could be either 1 or 5.

Let me check one more angle; is the pharmaceutical product a commodity offered for sale? Yes, absolutely. However, "consumer product", "commercial product" is a hyponym of product%1:06:01:: (sense 1).

In WordNet, "merchandise, ware, product" (sense 1) has hyponyms like cargo, commodity, consumer goods, retail store, etc. While "product, production" (sense 5) has hyponyms like alloys, animal product, end product, output, etc.

But a medicinal drug is a chemical substance? No, a medicine is a "drug," a "pharmacological agent." Here "product" means the medicine itself. Searching for "Summary of Product Characteristics" (SmPC), *product* refers to the *medicinal product.* So is a medicine a chemical substance formed in a reaction? No. The SmPC applies to the whole formulation, not just a chemical product.

Now I am narrowing in. Between sense 1 and sense 5. I'm guessing that sense 1 is more appropriate, since the SmPC applies to the commercialized medicine (the marketed drug), which is a commodity.

Re-reading the examples, "that store offers a variety of products" (sense 1) vs "they improve their product every year" (sense 5). In the context of the SmPC, "product" means the commercial product. I am leaning towards sense 1. Could "medicinal product" map to sense 1?

I think I will choose 1.

Double checking, "consumer product" in WordNet is a hyponym of commodity, trade good, good, which is the hypernym of product%1:06:01:: which means it is in the correct synset. So, the product%1:06:01:: (sense 1) is a hyponym of "commodity, trade good, good". Let me confirm; yes, it is "commodities offered for sale".

The Summary of Product Characteristics (SmPC) is for medicinal products. The "product" here is the *pharmaceutical product*.

Final decision: I am going with sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: part
Target surface form: part
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=part%1:04:03:: | definition=the part played by a person in bringing about a result | synonyms=contribution, share | examples=I am proud of my contribution in advancing the project; they all did their share of the work
2. sense_key=part%1:08:01:: | definition=a line of scalp that can be seen when sections of hair are combed in opposite directions | synonyms=parting | examples=his part was right in the middle
3. sense_key=part%1:09:00:: | definition=one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division | examples=the written part of the exam; the finance section of the company
4. sense_key=part%1:21:00:: | definition=assets belonging to or due to or contributed by an individual person or group | synonyms=share, portion, percentage | examples=he wanted his share in cash
5. sense_key=part%1:09:02:: | definition=that which concerns a person with regard to a particular role or situation | examples=it requires vigilance on our part; they resisted every effort on his part
6. sense_key=part%1:10:00:: | definition=the melody carried by a particular voice or instrument in polyphonic music | synonyms=voice | examples=he tried to sing the tenor part
7. sense_key=part%1:06:00:: | definition=something less than the whole of a human artifact | synonyms=portion | examples=the rear part of the house; glue the two parts together
8. sense_key=part%1:24:00:: | definition=something determined in relation to something that includes it | synonyms=portion, component part, component, constituent | examples=he wanted to feel a part of something bigger than himself; I read a portion of the manuscript
9. sense_key=part%1:15:00:: | definition=the extended spatial location of something | synonyms=region | examples=the farming regions of France; religions in all parts of the world
10. sense_key=part%1:17:00:: | definition=a portion of a natural object | synonyms=piece | examples=they analyzed the river into three parts; he needed a piece of granite
11. sense_key=part%1:04:01:: | definition=the actions and activities assigned to or required or expected of a person or group | synonyms=function, office, role | examples=the function of a teacher; the government must do its part
12. sense_key=part%1:09:01:: | definition=an actor's portrayal of someone in a play | synonyms=character, role, theatrical role, persona | examples=she played the part of Desdemona

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 8}
```

content:
```json
{"sense_index": 8}
```

reasoning_content:
**Analyzing "Part" in Context**

Okay, so I'm looking at the word "part" in the phrase "also part of the EPAR" within the context of the Summary of Product Characteristics (SPC) being related to the European Public Assessment Report (EPAR). My initial thought is to quickly cycle through potential senses and narrow it down. Let's see... we're looking for a word to describe the relationship between these two documents.

I'm initially considering senses like "section" or "portion," those seem relevant. Specifically, I'm trying to decide between senses that involve division or composition. I immediately think that "section" or "division" (Sense 3), or a "component" or "constituent" (Sense 8) are the front runners. Then, I had to double-check if the EPAR is considered a human artifact, which seems appropriate. So, "something less than the whole of a human artifact" (Sense 7) *could* be relevant, but I quickly decide it's less likely.

Okay, let's distinguish between Sense 3 and Sense 8. Sense 3, "one of the portions into which something is regarded as divided and which together constitute a whole" seems like the *written* portion of an exam. That's a good example, but is the EPAR *divided* into parts in that sense? It is, in a way, but the relationship feels more integral than just a segmented division. Sense 8, on the other hand, "something determined in relation to something that includes it," feels like a perfect fit, especially with those synonyms: "component part," "component," "constituent." I like the examples, "he wanted to feel a part of something bigger than himself; I read a portion of the manuscript."

I think that "part of the EPAR" implies that the SPC is a component of the larger document. Now, let's check WordNet and look at the specifics. Hmm, `part%1:24:00::` *is* defined as "something determined in relation to something that includes it," with synonyms like "portion, component part, component, constituent." That feels right on target. This aligns perfectly with a document being *part* of a larger document. Then, let's check Sense 3 again for comparison: `part%1:09:00::` is in the `cognition` category. Still, the written *part* of an exam makes sense.

Okay, "part of [a whole]" usually suggests Sense 8. Let's make this more concrete by substituting "component part" to see if it makes sense. Yes, "The SPC is also a component part of the EPAR." And that reads properly.

Now, wait... What about the usage of "part" without an article? "He is part of the team," "It is part of the EPAR." This is key. The relational nature of "part" here, not countable "a part," confirms Sense 8. The examples fit well: "he wanted to feel a part of something bigger than himself," or the very similar "I read a portion of the manuscript."

I'm now confident, especially after considering that the SPC *is* a "component" or "constituent" of the EPAR. Sense 8, `part%1:24:00::` is the correct sense.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
2. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
3. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
4. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
5. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
6. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
7. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
8. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
12. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession
13. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
14. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 14}
```

content:
```json
{"sense_index": 14}
```

reasoning_content:
**Analyzing the Meaning of "Active" in Context**

Okay, so the lemma I'm working with is "active," and the surface form is, unsurprisingly, also "active." The context is "The active substance in Alimta, pemetrexed, is a cytotoxic medicine..." Right away, my expert intuition kicks in. "Active substance" screams *pharmacology* or *chemistry*. We're talking about the part of a medicine that *does* something – that exerts an effect.

Let's see… Candidate 14 pops up: `sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient`. Bingo. That's a perfect fit. The definition and, especially, the example provided ("an active ingredient") align *precisely* with the context of an "active substance" in a drug. No ambiguity here. This is the sense we're after.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: substance
Target surface form: substance
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=substance%1:03:01:: | definition=a particular kind or species of matter with uniform properties | examples=shigella is one of the most toxic substances known to man
2. sense_key=substance%1:09:01:: | definition=the choicest or most essential or most vital part of some idea or experience | synonyms=kernel, core, center, centre, essence, gist | examples=the gist of the prosecutor's argument; the heart and soul of the Republican Party
3. sense_key=substance%1:03:00:: | definition=the real physical matter of which a person or thing consists | examples=DNA is the substance of our genes
4. sense_key=substance%1:21:00:: | definition=considerable capital (wealth or income) | synonyms=means | examples=he is a man of means
5. sense_key=substance%1:09:00:: | definition=the idea that is intended | synonyms=meaning | examples=What is the meaning of this proverb?
6. sense_key=substance%1:10:00:: | definition=what a communication that is about something is about | synonyms=message, content, subject matter
7. sense_key=substance%1:27:00:: | definition=material of a particular kind or constitution | examples=the immune response recognizes invading substances

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing "Substance" in a Medical Context**

Okay, so I'm looking at this Alimta leaflet and the phrase "The active substance in Alimta, pemetrexed, is a cytotoxic medicine...". My immediate task is to nail down the specific meaning of "substance" here, particularly in the context of pharmacology. I need to make sure I understand how this term is being used to make decisions.

First, I've got a list of possible senses from WordNet to consider. We're looking at things like "a particular kind or species of matter," "the choicest or most essential part," and even broader definitions like "material of a particular kind." My gut reaction is that we're dealing with the literal, chemical composition of the drug.

So, let's look at a few that seem relevant: "substance%1:03:01::" which is "a particular kind or species of matter with uniform properties," and "substance%1:27:00::" which is "material of a particular kind or constitution." The term "active substance" is used to describe the primary effective component of medicine and this makes sense. Then I check for specific chemical substances with a particular compound, and hyponyms of the term, such as "chemical substance".

Given that pemetrexed is a specific chemical compound, my understanding of how active ingredient/substance works suggests that the first definition, "a particular kind or species of matter with uniform properties," is the most accurate fit. It's the "active ingredient," the chemical entity within Alimta that exerts its cytotoxic effects. This meaning aligns with the pharmacological context perfectly.

Checking the WordNet hierarchy, I can see that "substance%1:03:01::" has hyponyms like "chemical substance" and "active agent," which confirms my analysis. This sense is a better fit than sense 7, "material of a particular kind or constitution." So, the best fit for "active substance" here is definitely sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine
2. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
3. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
4. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
**Deconstructing the Meaning of "Medicine"**

Okay, so the word "medicine" is the target here, and we need to zero in on its specific meaning within this context: "...pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing...)". Let's run through the potential senses. First, there's "punishment" – clearly not relevant here. That's a non-starter. Next, "branches of medical science" – while related, it feels too broad and doesn't quite capture the specific function described. It's too high-level. Then, there's the more direct sense: "something that treats or prevents or alleviates the symptoms of disease," in essence, "medication" or a "medicament." Finally, there's the "learned profession," the "practice of medicine" itself.

Given that pemetrexed is explicitly presented as "a medicine that kills cells," the most precise and accurate interpretation is undoubtedly the third sense: it's a *medication* or *drug*. The text specifically characterizes pemetrexed as having a cytotoxic effect, which aligns perfectly with this sense. Therefore, the interpretation is straightforward; the target word is describing a particular type of medicinal agent. Case closed.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
**My Analysis of "Medicine" in Context**

Okay, so the lemma I'm working with is "medicine," and the surface form is, unsurprisingly, also "medicine." Now, let's see what the context provides. I see "...a cytotoxic medicine (a medicine that kills cells...)." Right away, that's incredibly helpful. I need to nail down the precise meaning from the available senses: is this a punishment, a profession, or something to do with the field of medical science?

That context about killing cancer cells really narrows it down. Sense 1 doesn't fit at all, given this is clearly describing a physical substance, not a moral concept. Sense 3, the learned profession, doesn't align with the description either. And Sense 4, which refers to the branches of medical science, is too broad, I need to get more specific.

Therefore, Sense 2, "something that treats or prevents or alleviates the symptoms of disease (medication, medicament, medicinal drug)," is the only one that truly fits this specific description of "a cytotoxic medicine." It's a drug, a medication, designed to affect a biological process, in this case, the division of cancer cells. It's the perfect match. Case closed.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: kill
Target surface form: kills
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=kill%2:35:02:: | definition=deprive of life | examples=AIDS has killed thousands in Africa
2. sense_key=kill%2:30:03:: | definition=cause to cease operating | examples=kill the engine
3. sense_key=kill%2:42:00:: | definition=be fatal | examples=cigarettes kill; drunken driving kills
4. sense_key=kill%2:35:00:: | definition=cause to die; put to death, usually intentionally or knowingly | examples=This man killed several people when he tried to rob a bank; The farmer killed a pig for the holidays
5. sense_key=kill%2:30:02:: | definition=destroy a vitally essential quality of or in | examples=Eating artichokes kills the taste of all other foods
6. sense_key=kill%2:30:04:: | definition=tire out completely | examples=The daily stress of her work is killing her
7. sense_key=kill%2:30:00:: | definition=mark for deletion, rub off, or erase | synonyms=obliterate, wipe out | examples=kill these lines in the President's speech
8. sense_key=kill%2:39:00:: | definition=be the source of great pain for | examples=These new shoes are killing me!
9. sense_key=kill%2:30:08:: | definition=end or extinguish by forceful means | synonyms=stamp out | examples=Stamp out poverty!
10. sense_key=kill%2:35:05:: | definition=hit with great force | examples=He killed the ball
11. sense_key=kill%2:35:01:: | definition=cause the death of, without intention | examples=She was killed in the collision of three cars
12. sense_key=kill%2:41:01:: | definition=thwart the passage of | synonyms=shoot down, defeat, vote down, vote out | examples=kill a motion; he shot down the student's proposal
13. sense_key=kill%2:35:06:: | definition=hit with so much force as to make a return impossible, in racket games | examples=She killed the ball
14. sense_key=kill%2:37:00:: | definition=overwhelm with hilarity, pleasure, or admiration | examples=The comedian was so funny, he was killing me!
15. sense_key=kill%2:34:00:: | definition=drink down entirely | synonyms=toss off, pop, bolt down, belt down, pour down, down | examples=He downed three martinis before dinner; She killed a bottle of brandy that night

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{
  "sense_index": 1
}
```

reasoning_content:
**Analyzing the Semantics of "Kills" in a Cytotoxic Context**

Okay, so I'm presented with "kills" in the context of cytotoxic medicine. My immediate thought is to consider the lemma "kill" and the various senses WordNet offers. Let's see... I've got a list here: deprive of life, cause to cease operating, be fatal, cause to die (usually intentionally), destroy a vital quality, and cause death without intention.

The object is "cells that are dividing."  A medicine is the agent here. Which sense makes the most sense? "Deprive of life" seems like a good starting point, like when AIDS has killed thousands. "Cause to die" is also relevant, but often implies intentionality, which isn't the case here with medicine. And then there's the "without intention" sense, like in an accident.

Hmm, for medicines, it's more about destruction, causing the cells to cease functioning, causing them to die. WordNet has "cause to die" related to medicine, but is that the right fit here? I'm leaning toward either the "deprive of life" sense or the "cause to die" sense. With "deprive of life" the example is a disease or substance.

Let's look more closely. Sense 1, "deprive of life," is exemplified by "AIDS has killed thousands." That seems appropriate here, a substance causing death. Sense 4, "cause to die," has an intentional element I'm not seeing here. Wait, "deprive of life" perfectly encapsulates the action of a medicine. Sense 5 is interesting too ("destroy a vitally essential quality"), but isn't as precise.

Thinking it through, "deprive of life" seems most accurate, given the example of AIDS. It's that general "kill" sense. But is "cause to die" too broad? Now that I think about it, it makes more sense as the medicine isn't doing it intentionally. Maybe I'm getting bogged down in the nuances.

Let's double-check. I have:

*   `kill%2:35:02::` - deprive of life (AIDS killed thousands)
*   `kill%2:35:00::` - cause to die; put to death, usually intentionally (This man killed...)
*   `kill%2:35:01::` - cause the death of, without intention (She was killed in the collision...)

Since it's cytotoxic, it causes cells to die. This aligns very closely with the "deprive of life" sense, as the medicine effectively terminates the cells' viability. That feels right. Yes, "a medicine that kills cells" best fits "deprive of life" (kill%2:35:02).


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cells
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
3. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
4. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
7. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
**My Analysis of "Cells" in a Medical Context**

Okay, the target word is "cells," and the sentence clearly positions it within a biological context: we're talking about medicine, a cytotoxic medicine that *kills* them, and specifically, cancer cells, and further mentions the DNA/RNA. Alright, let's run through the senses quickly. We've got:

1.  *Small compartment* - Unlikely. Though there could be *some* loose, vague parallel to consider, it's irrelevant with the context we have.
2.  *Electric cell* - No, completely wrong here.
3.  *Monk/Nun Cubicle* - Definitely not applicable here.
4.  *Prison Cell* - Nope, that is completely unrelated.
5.  *Cellular phone* - Absolutely not.

And finally, the obvious winner, sense number 6: *the basic structural and functional unit of all organisms* – boom. That's it. It's the biological definition we're looking for, the building block of life. The mention of division, medicine designed to act upon those dividing structures...it's undeniable.

Therefore, sense index 6. Moving on.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: divide
Target surface form: dividing
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=divide%2:42:00:: | definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries
2. sense_key=divide%2:35:01:: | definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea
3. sense_key=divide%2:38:00:: | definition=make a division or separation | synonyms=separate
4. sense_key=divide%2:41:00:: | definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire after World War I
5. sense_key=divide%2:31:00:: | definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven?
6. sense_key=divide%2:35:00:: | definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 4}
```

content:
```json
{"sense_index": 4}
```

reasoning_content:
**Okay, let's break this down for "dividing" in the context of cytotoxic medicine. My focus is on the biological sense, specifically cell division, so it's all about how these drugs affect cells' ability to multiply.**

Initially, I reviewed the candidate senses, automatically ruling out those that don't fit the biological context - acting as a barrier, forcing apart, or performing a mathematical division. The key is how the cell is coming apart or multiplying by separation. The most likely options are where things "separate into parts or portions," "come apart," or "make a division/separation".

I keep in mind, I need to check these definitions in light of the biological context. I initially didn't see the specific biological definition of "divide" in the candidate senses, but the context is that it's dealing with cells, so I have to keep that in mind. I reviewed the candidates and their definitions.

Now, which is the best fit? "Separate into parts or portions" really clicks when thinking of cell division, as in, a single cell separating into two. I checked WordNet to confirm. WordNet does include this under "separate into parts or portions" with "split" as a synonym. Bingo! I also checked other synonyms. "Come apart" seems too... abrupt, implying a breaking rather than the controlled process of division. "Make a division or separation" could work, but seems a bit broader. It looks like "separate into parts or portions" can be intransitive! "The cells divide" is correct! This one, divide%2:41:00::, is the winner!

To make sure, I looked at WordNet definitions and checked for sentences with "cells divide" and mapped to "separate into parts or portions". This is correct! Let me double check if it covers the intransitive sense. It works.

I reviewed the candidate senses. "Separate into parts or portions" (divide%2:41:00::) is most likely the correct sense. I checked the SemCor examples to confirm.

Yes, in SemCor, the biological division of cells is annotated as "divide%2:41:00:: (separate into parts or portions)". And now, I am confident that sense_key=divide%2:41:00:: is the best one.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: body
Target surface form: body
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=body%1:14:02:: | definition=a collection of particulars considered as a system | examples=a body of law; a body of doctrine
2. sense_key=body%1:07:00:: | definition=the property of holding together and retaining its shape | synonyms=consistency, consistence, eubstance | examples=wool has more body than rayon; when the dough has enough consistency it is ready to bake
3. sense_key=body%1:06:01:: | definition=a resonating chamber in a musical instrument (as the body of a violin) | synonyms=soundbox
4. sense_key=body%1:17:00:: | definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. sense_key=body%1:10:00:: | definition=the central message of a communication | examples=the body of the message was short
6. sense_key=body%1:08:02:: | definition=a natural object consisting of a dead animal or person | synonyms=dead body | examples=they found the body in the lake
7. sense_key=body%1:06:00:: | definition=the external structure of a vehicle | examples=the body of the car was badly rusted
8. sense_key=body%1:08:00:: | definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
9. sense_key=body%1:08:01:: | definition=the body excluding the head and neck and limbs | synonyms=torso, trunk | examples=they moved their arms and legs and bodies
10. sense_key=body%1:07:01:: | definition=the main mass of a thing
11. sense_key=body%1:14:00:: | definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium; the student body

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 8}
```

reasoning_content:
**Analyzing the Meaning of "Body" in a Biological Context**

Okay, so the word "body" appears in this sentence about how pemetrexed functions. My immediate thought is that this refers to the physical structure, the organism itself – the human body in this case, obviously.

I'm running through the senses of "body" that I've got, and sense number 8, the definition of the *entire structure of an organism* (animal, plant, or human being), and its synonyms like "organic structure" and "physical structure", leaps out. This fits the context perfectly: "In the *body*, pemetrexed is converted..." It is a very good fit.

Let's quickly dismiss the other contenders. A "collection of particulars," "property of holding together," "resonating chamber," "individual 3-dimensional object," "central message," "dead body," "external structure of a vehicle," "torso, trunk," "main mass of a thing," or a "group of persons" are all clearly not applicable here. Sense 8 is clearly the correct one for this biological discussion.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: convert
Target surface form: converted
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=convert%2:33:01:: | definition=complete successfully | examples=score a penalty shot or free throw
2. sense_key=convert%2:30:07:: | definition=cause to adopt a new or different faith | examples=The missionaries converted the Indian population
3. sense_key=convert%2:32:00:: | definition=make (someone) agree, understand, or realize the truth or validity of something | synonyms=win over, convince | examples=He had finally convinced several customers of the advantages of his product
4. sense_key=convert%2:30:04:: | definition=change in nature, purpose, or function; undergo a chemical change | examples=The substance converts to an acid
5. sense_key=convert%2:33:02:: | definition=score an extra point or points after touchdown by kicking the ball through the uprights or advancing the ball into the end zone | examples=Smith converted and his team won
6. sense_key=convert%2:30:09:: | definition=exchange a penalty for a less severe one | synonyms=commute, exchange
7. sense_key=convert%2:30:03:: | definition=change the nature, purpose, or function of something | examples=convert lead into gold; convert hotels into jails
8. sense_key=convert%2:30:00:: | definition=change from one system to another or to a new plan or policy | synonyms=change over | examples=We converted from 220 to 110 Volt
9. sense_key=convert%2:30:01:: | definition=change religious beliefs, or adopt a religious belief | examples=She converted to Buddhism
10. sense_key=convert%2:30:02:: | definition=exchange or replace with another, usually of the same kind or category | synonyms=change, exchange, commute | examples=Could you convert my dollars into pounds?; He changed his name
11. sense_key=convert%2:33:00:: | definition=score (a spare)

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 7}
```

content:
```json
{"sense_index": 7}
```

reasoning_content:
**Analyzing the "Convert" Sense in Context**

Okay, so the lemma is "convert," surface form "converted," and the context is "In the body, pemetrexed is converted into an active form..." Right off the bat, I need to pinpoint the correct sense from the list. Given the biological context, the senses related to faith or scoring are clearly irrelevant. I'm focusing on senses involving change.

The passive construction, "is converted," is the key.  It tells me it's a transitive usage – something is *being* converted *into* something else. Sense 4, "undergo a chemical change," seems promising initially but is listed as intransitive, like "The substance converts to an acid." Not a fit. The sentence implies that something (the body or enzymes) *does* the converting.

Sense 7, "change the nature, purpose, or function of something," is the more likely contender. It's transitive ("convert lead into gold") which mirrors the structure of the context. We're looking at something being transformed. Now, I need to confirm if sense 7 encompasses chemical changes, and if it's broad enough to cover biological transformations.

Looking back at WordNet, sense 4 is intransitive while sense 7 is transitive, and I recall that the active counterpart of the sentence would be something like, "[The body/enzymes] convert pemetrexed into an active form". "Convert lead into gold" (sense 7) seems to be the right fit here. I'm checking back to make sure, but the passive nature of "is converted" definitely points towards a transitive verb.

Looking at the definitions side-by-side:

*   Sense 4: "change in nature, purpose, or function; undergo a chemical change" - seems to be chemical, but it is intransitive.
*   Sense 7: "change the nature, purpose, or function of something" - this one works.

"Convert into" is a phrase used in sense 7, like "convert lead into gold," which aligns perfectly with "converted into an active form." Now, to be absolutely sure, I'm checking the example for sense 4, which is "The substance converts *to* an acid" - the "to" rules out sense 4.

Therefore, even though sense 4 directly references chemical change, sense 7's transitive nature and the matching phrase "convert into" with the "pemetrexed is converted into an active form" make it the most appropriate sense.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
4. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
5. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession
6. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
7. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
11. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
12. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
13. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
14. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 13}
```

content:
```json
{"sense_index": 13}
```

reasoning_content:
**Analyzing the "Active" Lemma in a Biological Context**

Okay, the target word is "active" and it's used in the sentence "pemetrexed is converted into an active form..." Right away, my brain jumps to the idea of the *active form* of a substance, probably a drug or chemical, which is a very specific concept in my field. I'm thinking about its biological or chemical impact.

Candidate 13 seems like a strong contender: sense_key=active%3:00:07:: with the definition "exerting influence or producing a change or effect." The provided examples, "an active ingredient," really solidify this connection. The context mentions "the active substance in Alimta" and being "converted into an active form," which screams "exerting an effect" – it's biologically or chemically *active*.

Let's quickly rule out other senses, just to be thorough: full of activity (too general), military (completely off), volcanos (nope), tending to become more severe (not relevant), full-time work (irrelevant), disposed to take action (slightly related, but not in this specific case), grammar (clearly not), in operation (alive) (not what we're looking for), sunspots (no way!), energetic activity (too general), volcanos capable of erupting (again, nope), taking part (involved) (not the primary meaning), grammar (dynamic verbs) (nope!).

Candidate 13, "exerting influence or producing a change or effect (active ingredient)," perfectly captures the sense of "active form" as it relates to a chemical/pharmacological context, as if it's the "active ingredient". I'm confident that's the correct sense.