[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: past
Target surface form: past
Context:
Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the <t>past</t>. The medicine can only be obtained with a prescription.

Candidate senses:
1. sense_key=past%1:28:00:: | definition=the time that has elapsed | synonyms=past times, yesteryear | examples=forget the past
2. sense_key=past%1:28:01:: | definition=a earlier period in someone's life (especially one that they have reason to keep secret) | examples=reporters dug into the candidate's past
3. sense_key=past%1:10:00:: | definition=a verb tense that expresses actions or states in the past | synonyms=past tense

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Sense of "Past"**

Okay, so the target is "past" and it appears as "past" in the text. Let's see... the context is "...patients who have received another type of chemotherapy in the past." Right off the bat, I need to evaluate the potential senses of "past" in this sentence. The dictionary senses I've got are:

1.  "the time that has elapsed" – that's a general definition, like "forget the past."
2.  "a earlier period in someone's life (especially one that they have reason to keep secret)" – This definitely seems like a distinct concept. Not likely here.
3.  "a verb tense that expresses actions or states in the past" – Nope. The context isn't about grammar.

Looking at the context "in the past", I'm leaning heavily towards Sense 1. It’s clearly referring to "the time that has elapsed," a timeframe. It can't be a hidden part of someone's life or a tense. "In the past" aligns perfectly with the elapsed-time definition. Sense 1 is the clear winner. This is a pretty straightforward disambiguation.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The <t>medicine</t> can only be obtained with a prescription. How is Alimta used?

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

finish_reason: stop

content:
```json
{"sense_index": 2}
```

role: assistant

reasoning_content:
**Analyzing the Context of Alimta**

Okay, so we're dealing with "Alimta," which I know contains pemetrexed and is indicated for cancer treatment. The text states it requires a prescription. My immediate task is to categorize this information. My initial sense candidates are pretty straightforward: a branch of medical science, something that treats disease (a medication, specifically), the learned profession, or, less likely here, punishment. Given the information and my expertise, sense number two is the clear winner. The reference is directly to the drug "Alimta" itself, which is undoubtedly a medication. The prescription aspect further solidifies this understanding, placing it firmly within the realm of medicinal drugs that require professional oversight. This is routine clinical knowledge.

type: thinking

service_tier: default

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: only
Target surface form: only
Context:
It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can <t>only</t> be obtained with a prescription. How is Alimta used?

Candidate senses:
1. sense_key=only%4:02:02:: | definition=and nothing more | synonyms=merely, simply, just, but | examples=I was merely asking; it is simply a matter of time
2. sense_key=only%4:02:01:: | definition=without any others being included or involved | synonyms=entirely, exclusively, solely, alone | examples=was entirely to blame; a school devoted entirely to the needs of problem children
3. sense_key=only%4:02:00:: | definition=with nevertheless the final result | examples=He arrived only to find his wife dead; We won only to lose again in the next round
4. sense_key=only%4:02:04:: | definition=in the final outcome | examples=These news will only make you more upset
5. sense_key=only%4:02:06:: | definition=except that | examples=It was the same story; only this time she came out better
6. sense_key=only%4:02:03:: | definition=never except when | synonyms=only if, only when | examples=call me only if your cold gets worse
7. sense_key=only%4:02:05:: | definition=as recently as | examples=I spoke to him only an hour ago

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
**Analyzing the Nuances of "Only"**

Okay, so I'm looking at the word "only" in the sentence "The medicine can only be obtained with a prescription." My first thought is to narrow down the possible senses. There are several options in the list provided, and each needs careful consideration within this specific context.

Initially, I considered sense 1, "and nothing more" (merely, simply). But quickly I realized that's not quite right here. It's not about minimization; it's about restriction. Then, sense 2, "without any others being included or involved" (exclusively, solely), jumped out. That seems promising. I mean, "The medicine can solely be obtained..." or "...exclusively with a prescription" – that fits pretty well.

Sense 6, "never except when" (only if, only when), also seemed relevant for a moment. Replacing it with "The medicine can be obtained only if you have a prescription." But here's the catch: the phrase uses "only with," which seems to map more to "exclusively."

I was focusing on that connection between "only with" and how to replace the prepositional phrase. Then I thought about the core meaning: the medicine's availability is restricted to a prescription. This means it can *only* be obtained in that way, and in no other.

I went back to sense 2. Let's see how "exclusively" or "solely" works in the sentence. Replacing "only" with these words works and makes sense. It perfectly captures the idea that a prescription is the *exclusive* requirement.

Let's check the synonyms to verify "exclusively".  The examples of these also match perfectly here: "a school devoted entirely to the needs" aligns with "can be obtained exclusively with a prescription."

I then went back to sense 6. "Only if" and "only when" seem to work with a conditional statement. However, in this case, "only with" translates to "exclusively" because of the way "with" functions. Therefore, sense 2 does appear to be the most accurate because the phrase includes "only with."
So, I think I've confirmed it. Sense 2 is the correct interpretation. "Only" in this context translates to "exclusively" or "solely," highlighting the exclusivity of the prescription as the means to obtain the medicine.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: obtain
Target surface form: obtained
Context:
It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be <t>obtained</t> with a prescription. How is Alimta used?

Candidate senses:
1. sense_key=obtain%2:40:00:: | definition=come into possession of | examples=How did you obtain the visa?
2. sense_key=obtain%2:30:00:: | definition=receive a specified treatment (abstract) | synonyms=receive, get, find, incur | examples=These aspects of civilization do not find expression or receive an interpretation; His movie received a good review
3. sense_key=obtain%2:42:00:: | definition=be valid, applicable, or true | synonyms=prevail, hold | examples=This theory still holds

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Usage of "Obtained"**

Okay, so the task is to figure out the intended meaning of "obtained" in the sentence "The medicine can only be obtained with a prescription." The surface form is clearly "obtained", derived from the lemma "obtain". Right, let's look at the candidate senses.

Sense 1: "come into possession of". This seems immediately promising. The definition suggests a straightforward acquisition. This aligns with getting a medicine.

Sense 2: "receive a specified treatment". Okay, this includes things like "receive an interpretation" or "incur." This doesn't seem right. It's more about experiencing or being subjected to something, not directly acquiring.

Sense 3: "be valid, applicable, or true." This is clearly about something being applicable, or prevailing (like a rule). Definitely not applicable here.

Okay, back to Sense 1. "come into possession of" really hits the mark. The medicine is *being acquired*, *obtained*. It's a straightforward acquisition process, just like how you'd "obtain" a visa.

Let me check. Does "come into possession of" fit in the provided context? Yes. "How did you obtain the visa?" is a relevant example and feels synonymous with the sentence. So, I'm confident. The first sense, "obtain%2:40:00:: | come into possession of," is the correct one in this context.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: prescription
Target surface form: prescription
Context:
It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a <t>prescription</t>. How is Alimta used?

Candidate senses:
1. sense_key=prescription%1:10:00:: | definition=directions prescribed beforehand; the action of prescribing authoritative rules or directions | examples=I tried to follow her prescription for success
2. sense_key=prescription%1:06:00:: | definition=a drug that is available only with written instructions from a doctor or dentist to a pharmacist | synonyms=prescription drug, prescription medicine, ethical drug | examples=he told the doctor that he had been taking his prescription regularly
3. sense_key=prescription%1:10:02:: | definition=written instructions for an optician on the lenses for a given person
4. sense_key=prescription%1:10:01:: | definition=written instructions from a physician or dentist to a druggist concerning the form and dosage of a drug to be issued to a given patient

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 4}
```

content:
```json
{"sense_index": 4}
```

reasoning_content:
**Deconstructing "Prescription" in Context**

Okay, the target word is "prescription," and the phrase I'm working with is "The medicine can only be obtained with a prescription." Right away, I start mentally parsing the potential senses. I've got a few: the broader act of prescribing directions, the drug itself being called a "prescription drug," instructions for eyeglasses, and, finally, the actual written order from the doctor.

Given the context, "with a prescription" strongly suggests the written authorization, the doctor's order. Is it the medicine itself or the written instructions that are obtained with the prescription? Thinking about it, the medicine is *obtained with* the prescription. It's the written slip of paper (sense 4) that allows you to get the medicine. Now, sense 2—"prescription drug"—refers to the medication. Someone might say "he's taking his prescription regularly" referring to the medication. But the sentence uses "with a prescription," therefore, my analysis is "prescription" here refers to the written instructions (sense 4).

Let me confirm this. "With a prescription" implies authorization, and that seems to point directly to the written document from the doctor. Sense 4 describes it perfectly: "written instructions from a physician or dentist to a druggist concerning the form and dosage of a drug to be issued to a given patient." That's the one.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: used
Context:
What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta <t>used</t>? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy.

Candidate senses:
1. sense_key=use%2:34:01:: | definition=put into service; make work or employ for a particular purpose or for its inherent or natural purpose | synonyms=utilize, utilise, apply, employ | examples=use your head!; we only use Spanish at home
2. sense_key=use%2:34:02:: | definition=take or consume (regularly or habitually) | synonyms=habituate | examples=She uses drugs rarely
3. sense_key=use%2:34:00:: | definition=use up, consume fully | synonyms=expend | examples=The legislature expended its time on school questions
4. sense_key=use%2:41:14:: | definition=seek or achieve an end by using to one's advantage | examples=She uses her influential friends to get jobs; The president's wife used her good connections
5. sense_key=use%2:41:04:: | definition=avail oneself to | synonyms=practice, apply | examples=apply a principle; practice a religion
6. sense_key=use%2:41:03:: | definition=habitually do something (use only in the past tense) | examples=She used to call her mother every week but now she calls only occasionally; I used to get sick when I ate in that dining hall

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the "Used" in Context**

Okay, the target is "use," and the surface form is "used" in this sentence about Alimta. The context is "How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy." Right, Alimta is a medication, a type of anticancer chemotherapy. So, "How is Alimta used?" – that's essentially asking how it's *employed* or *administered* to achieve its therapeutic purpose.

Now, let's consider the possible senses. Wait, there's a sense that refers to drug abuse ("take or consume regularly"), but that's not what we're looking at here. This is about administering a drug, not habitual consumption.

Based on my analysis, sense 1 is: put into service; make work or employ for a particular purpose or for its inherent or natural purpose (utilize, apply, employ).

Let's look at the context again: "How is Alimta used?" -> How is it administered / utilized.

Yes, sense 1 is appropriate.

There are no additional medical-specific senses that are available.

The available senses are as follows:
1. put into service (utilize, utilise, apply, employ)
2. take or consume (regularly or habitually) (habituate) -> uses drugs
3. use up, consume fully (expend)
4. seek or achieve an end by using to one's advantage -> exploit
5. avail oneself to (practice, apply) -> apply a principle
6. habitually do something -> used to

Sense 1 is the most fitting, perfectly capturing the idea of how the medication is being *utilized/employed* in the treatment process.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: only
Target surface form: only
Context:
Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should <t>only</t> be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight).

Candidate senses:
1. sense_key=only%4:02:02:: | definition=and nothing more | synonyms=merely, simply, just, but | examples=I was merely asking; it is simply a matter of time
2. sense_key=only%4:02:01:: | definition=without any others being included or involved | synonyms=entirely, exclusively, solely, alone | examples=was entirely to blame; a school devoted entirely to the needs of problem children
3. sense_key=only%4:02:00:: | definition=with nevertheless the final result | examples=He arrived only to find his wife dead; We won only to lose again in the next round
4. sense_key=only%4:02:04:: | definition=in the final outcome | examples=These news will only make you more upset
5. sense_key=only%4:02:06:: | definition=except that | examples=It was the same story; only this time she came out better
6. sense_key=only%4:02:03:: | definition=never except when | synonyms=only if, only when | examples=call me only if your cold gets worse
7. sense_key=only%4:02:05:: | definition=as recently as | examples=I spoke to him only an hour ago

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 2}
```

reasoning_content:
**Analyzing the Semantic Range of "Only"**

Okay, so the task is to disambiguate "only" in the sentence "Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy." My initial thought is to run through the candidate senses and figure out which one fits the context best.

The options, as presented, seem to be: "and nothing more" (merely), "without any others being included or involved" (exclusively), something about final results, something about exceptions...hmm.

My immediate impression is that "should only be given under..." suggests *exclusivity* or perhaps a *conditional* restriction. Let's see...I'm leaning heavily towards "exclusively" here. So, sense 2: "without any others being included or involved" seems promising. Let's go through the synonyms -- entirely, exclusively, solely, alone. Fits. Okay, let's explore more specifically. Is it "merely, simply, just"? No. And I'm pretty sure it can't be conditional here, because "only when" or "only if" wouldn't grammatically fit.

Let's test sense 2. "Should solely be given under..." or "should exclusively be given under...". Yes, that makes perfect sense!

Just to be safe, I'm going to quickly check the other candidate senses just to make sure. Does "should merely be given..." make sense? No, it implies something different.

Ah, okay, so if I replace "only" with "exclusively", it works: "Alimta should exclusively be given under the supervision..." And if I replace it with "solely," it still makes sense. Great!

Okay, sense 1 is definitely wrong. It's not a matter of "and nothing more". And sense 6, which is usually related to "only if" or "only when," doesn't fit the sentence structure.

So, let's go back and solidify this assessment. "Only" here indicates "without any others being included or involved."

The phrase, "The medicine can *only* be obtained with a prescription," is exactly analogous. "Alimta should *only* be given under..." - both times "exclusively" works well.

Yep, it's definitely not "merely". My gut feeling is right: the adverbial usage is key here. It modifies the verb "be given" and indicates that the action can occur under one specific set of circumstances.

Yes, sense 2 is the correct one. The word "only" acts as an adverb in this scenario, meaning "should be given exclusively."


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: give
Target surface form: given
Context:
Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be <t>given</t> under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight).

Candidate senses:
1. sense_key=give%2:40:03:: | definition=cause to have, in the abstract sense or physical sense | examples=She gave him a black eye; The draft gave me a cold
2. sense_key=give%2:40:05:: | definition=be the cause or source of | synonyms=yield, afford | examples=He gave me a lot of trouble; Our meeting afforded much interesting information
3. sense_key=give%2:40:00:: | definition=transfer possession of something concrete or abstract to somebody | examples=I gave her my money; can you give me lessons?
4. sense_key=give%2:40:07:: | definition=convey or reveal information | examples=Give one's name
5. sense_key=give%2:32:01:: | definition=convey, as of a compliment, regards, attention, etc.; bestow | synonyms=pay | examples=Don't pay him any mind; give the orders
6. sense_key=give%2:36:02:: | definition=organize or be responsible for | synonyms=hold, throw, have, make | examples=hold a reception; have, throw, or make a party
7. sense_key=give%2:32:00:: | definition=convey or communicate; of a smile, a look, a physical gesture | synonyms=throw | examples=Throw a glance; She gave me a dirty look
8. sense_key=give%2:40:01:: | definition=give as a present; make a gift of | synonyms=gift, present | examples=What will you give her for her birthday?
9. sense_key=give%2:36:03:: | definition=cause to happen or be responsible for | synonyms=yield | examples=His two singles gave the team the victory
10. sense_key=give%2:31:02:: | definition=dedicate | synonyms=pay, devote | examples=give thought to; give priority to
11. sense_key=give%2:36:00:: | definition=give or supply | synonyms=render, yield, return, generate | examples=The cow brings in 5 liters of milk; This year's crop yielded 1,000 bushels of corn
12. sense_key=give%2:40:09:: | definition=transmit (knowledge or skills) | synonyms=impart, leave, pass on | examples=give a secret to the Russians; leave your name and address here
13. sense_key=give%2:36:01:: | definition=bring about | synonyms=establish | examples=The trompe l'oeil-illusion establishes depth
14. sense_key=give%2:40:02:: | definition=leave with; give temporarily | examples=Can I give you my keys while I go in the pool?; Can I give you the children for the weekend?
15. sense_key=give%2:41:00:: | definition=emit or utter | examples=Give a gulp; give a yelp
16. sense_key=give%2:40:10:: | definition=endure the loss of | synonyms=sacrifice | examples=He gave his life for his children; I gave two sons to the war
17. sense_key=give%2:40:06:: | definition=place into the hands or custody of | synonyms=pass, hand, reach, pass on, turn over | examples=hand me the spoon, please; Turn the files over to me, please
18. sense_key=give%2:32:03:: | definition=give entirely to a specific person, activity, or cause | synonyms=dedicate, consecrate, commit, devote | examples=She committed herself to the work of God; give one's talents to a good cause
19. sense_key=give%2:40:13:: | definition=give (as medicine) | examples=I gave him the drug
20. sense_key=give%2:40:14:: | definition=give or convey physically | synonyms=apply | examples=She gave him First Aid; I gave him a punch in the nose
21. sense_key=give%2:32:02:: | definition=bestow | synonyms=render | examples=give homage; render thanks
22. sense_key=give%2:40:11:: | definition=bestow, especially officially | synonyms=grant | examples=grant a degree; give a divorce
23. sense_key=give%2:38:00:: | definition=move in order to make room for someone for something | synonyms=move over, give way, ease up, yield | examples=The park gave way to a supermarket; `Move over,' he told the crowd
24. sense_key=give%2:34:00:: | definition=give food to | synonyms=feed | examples=Feed the starving children in India; don't give the child this tough meat
25. sense_key=give%2:40:08:: | definition=contribute to some cause | synonyms=contribute, chip in, kick in | examples=I gave at the office
26. sense_key=give%2:38:13:: | definition=break down, literally or metaphorically | synonyms=collapse, fall in, cave in, give way, break, founder | examples=The wall collapsed; The business collapsed
27. sense_key=give%2:31:00:: | definition=estimate the duration or outcome of something | examples=He gave the patient three months to live; I gave him a very good chance at success
28. sense_key=give%2:41:10:: | definition=execute and deliver | examples=Give bond
29. sense_key=give%2:40:12:: | definition=deliver in exchange or recompense | examples=I'll give you three books for four CDs
30. sense_key=give%2:40:15:: | definition=afford access to | synonyms=afford, open | examples=the door opens to the patio; The French doors give onto a terrace
31. sense_key=give%2:36:13:: | definition=present to view | examples=He gave the sign to start
32. sense_key=give%2:36:12:: | definition=perform for an audience | examples=Pollini is giving another concert in New York
33. sense_key=give%2:35:00:: | definition=be flexible under stress of physical force | synonyms=yield | examples=This material doesn't give
34. sense_key=give%2:34:10:: | definition=propose | examples=He gave the first of many toasts at the birthday party
35. sense_key=give%2:32:11:: | definition=accord by verdict | examples=give a decision for the plaintiff
36. sense_key=give%2:32:08:: | definition=manifest or show | examples=This student gives promise of real creativity; The office gave evidence of tampering
37. sense_key=give%2:32:15:: | definition=offer in good faith | examples=He gave her his word
38. sense_key=give%2:32:14:: | definition=submit for consideration, judgment, or use | examples=give one's opinion; give an excuse
39. sense_key=give%2:32:09:: | definition=guide or direct, as by behavior of persuasion | examples=You gave me to think that you agreed with me
40. sense_key=give%2:32:07:: | definition=allow to have or take | examples=I give you two minutes to respond
41. sense_key=give%2:32:10:: | definition=inflict as a punishment | examples=She gave the boy a good spanking; The judge gave me 10 years
42. sense_key=give%2:30:13:: | definition=occur | examples=what gives?
43. sense_key=give%2:29:11:: | definition=consent to engage in sexual intercourse with a man | examples=She gave herself to many men
44. sense_key=give%2:29:10:: | definition=proffer (a body part) | examples=She gave her hand to her little sister

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 19}
```

content:
```json
{"sense_index": 19}
```

reasoning_content:
**Analyzing the "Give" Sense for Medical Context**

Okay, so the task at hand is to pinpoint the correct sense of "give" when it appears as "given" in this sentence about Alimta, a cancer medicine. The context is pretty clear: "Alimta should only be given under the supervision of a doctor..." It's obviously about administering a medication.

Let's quickly run through the candidate senses. Hmm, sense 1, "cause to have," feels a bit too broad. Sense 2, "be the cause or source of," seems a bit off too. Sense 3, "transfer possession," that’s closer, but not quite right in this medical scenario. Then, bingo! Sense 19, "give (as medicine)," has hit the mark. It's spot on. The definition fits like a glove, especially given the Alimta context.

Double-checking... "give (as medicine)" – perfect. The example "I gave him the drug" solidifies it. Okay, sense 19 it is! Let's just make sure the index is correct... Yep, index 19. So, the sense index is definitely 19.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: doctor
Target surface form: doctor
Context:
Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a <t>doctor</t> who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight).

Candidate senses:
1. sense_key=doctor%1:18:00:: | definition=a licensed medical practitioner | synonyms=doc, physician, MD, Dr., medico | examples=I felt so bad I went to see my doctor
2. sense_key=doctor%1:18:02:: | definition=(Roman Catholic Church) a title conferred on 33 saints who distinguished themselves through the orthodoxy of their theological teaching | synonyms=Doctor of the Church | examples=the Doctors of the Church greatly influenced Christian thought down to the late Middle Ages
3. sense_key=doctor%1:04:00:: | definition=children take the roles of physician or patient or nurse and pretend they are at the physician's office | examples=the children explored each other's bodies by playing the game of doctor
4. sense_key=doctor%1:18:01:: | definition=a person who holds Ph.D. degree (or the equivalent) from an academic institution | synonyms=Dr. | examples=she is a doctor of philosophy in physics

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Nuances of "Doctor"**

Okay, so the task is to pinpoint the correct sense of "doctor" within this sentence: "Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy." Right away, my expert intuition kicks in. We're talking about a pharmaceutical context, specifically anticancer chemotherapy. This immediately narrows the field.

I've got a few candidate senses popping up: a licensed medical practitioner (the physician), Doctor of the Church (clearly irrelevant here), the game "doctor" (completely out of bounds), and a Ph.D. degree holder (less likely, but requires consideration given some crossover fields).

Given that we're dealing with chemotherapy administration, the "doctor" in question is clearly *supervising* the process. This demands a medical understanding of cancer treatment, its side effects, and the drug itself – which, frankly, a Ph.D., while knowledgeable in some aspects, may not necessarily possess the clinical experience for. The only sense that fits the bill is the **licensed medical practitioner (physician)**. The term "qualified in the use of anticancer chemotherapy" is a direct indicator of the need for medical training and a license to prescribe and supervise. Sense 1 is the most appropriate.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: use
Context:
Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the <t>use</t> of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight).

Candidate senses:
1. sense_key=use%1:04:00:: | definition=the act of using | synonyms=usage, utilization, utilisation, employment, exercise | examples=he warned against the use of narcotic drugs; skilled in the utilization of computers
2. sense_key=use%1:07:00:: | definition=what something is used for | synonyms=function, purpose, role | examples=the function of an auger is to bore holes; ballet is beautiful but what use is it?
3. sense_key=use%1:07:02:: | definition=a particular service | examples=he put his knowledge to good use; patrons have their uses
4. sense_key=use%1:22:00:: | definition=(economics) the utilization of economic goods to satisfy needs or in manufacturing | synonyms=consumption, economic consumption, usance, use of goods and services | examples=the consumption of energy has increased steadily
5. sense_key=use%1:04:01:: | definition=(psychology) an automatic pattern of behavior in reaction to a specific situation; may be inherited or acquired through frequent repetition | synonyms=habit | examples=owls have nocturnal habits; she had a habit twirling the ends of her hair
6. sense_key=use%1:04:02:: | definition=exerting shrewd or devious influence especially for one's own advantage | synonyms=manipulation | examples=his manipulation of his friends was scandalous
7. sense_key=use%1:07:03:: | definition=(law) the exercise of the legal right to enjoy the benefits of owning property | synonyms=enjoyment | examples=we were given the use of his boat

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the "Use" Sense in Context**

Okay, so the task at hand is to determine the appropriate sense of "use" in the sentence: "Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy." The target lemma is "use," and the surface form is, well, "use." Straightforward enough.

I've been presented with several candidate senses. Let's run through them quickly, keeping the context in mind.

Sense 1: "the act of using." This seems immediately promising, given the phrasing "qualified in the *use* of..." The definition aligns well, and the provided examples, like "skilled in the utilization of computers," feel directly applicable to the idea of a doctor being skilled in the *use* of a chemotherapy drug.

Sense 2: "what something is used for (function)." Not a good fit. We aren't talking about the function of chemotherapy itself here.

Sense 3: "a particular service." Doesn't apply here.

Sense 4: "consumption." Clearly wrong.

Sense 5: "(psychology) an automatic pattern of behavior." Way off.

Sense 6: "exerting shrewd or devious influence." Nope.

Sense 7: "(law) the exercise of the legal right." No legal implications here.

Okay, let's circle back to Sense 1 and double check my initial assessment. "Qualified in the *use* of anticancer chemotherapy" strongly suggests expertise in *the act of applying* or *administering* the drug. The "skilled in the utilization of computers" example feels like a perfect analogy. The doctor isn't just aware of the drug; they know how to *employ* it effectively.

Given the context, I'm confident that Sense 1: "the act of using," is the correct interpretation.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: dose
Target surface form: dose
Context:
Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended <t>dose</t> of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes.

Candidate senses:
1. sense_key=dose%1:06:00:: | definition=a measured portion of medicine taken at any one time | synonyms=dosage
2. sense_key=dose%1:23:00:: | definition=the quantity of an active agent (substance or radiation) taken in or absorbed at any one time | synonyms=dosage
3. sense_key=dose%1:26:00:: | definition=a communicable infection transmitted by sexual intercourse or genital contact | synonyms=venereal disease, VD, venereal infection, social disease, Cupid's itch, Cupid's disease
4. sense_key=dose%1:06:01:: | definition=street name for lysergic acid diethylamide | synonyms=acid, back breaker, battery-acid, dot, Elvis, loony toons

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Meaning of "Dose" in a Clinical Context**

Okay, so I'm looking at "dose" in the context of "The recommended dose of Alimta is 500 mg per square metre of body surface area..." and immediately I know Alimta is a chemotherapy drug, an anticancer medicine. My mind jumps to the different senses of "dose" - a measured portion of medicine (Sense 1) or the quantity of an active agent (Sense 2). Both seem relevant initially, but the key is the explicit reference to Alimta as a "medicine." Sense 1 directly relates to a measured *portion* of medicine, which aligns perfectly with how we use it clinically.

Just to be absolutely sure, let me double-check the WordNet gloss. Sense 1 is indeed "a measured portion of medicine taken at any one time," while Sense 2 is broader and describes "the quantity of an active agent." The specific phrase, "The recommended dose of Alimta...", is referring to the *specific amount* to be administered. Therefore, Sense 1 is definitely the most precise and appropriate interpretation in this pharmaceutical setting. The context demands the narrow focus of the measured portion for drug administration.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: mg
Target surface form: mg
Context:
Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 <t>mg</t> per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes.

Candidate senses:
1. sense_key=mg%1:23:00:: | definition=one thousandth (1/1,000) gram | synonyms=milligram
2. sense_key=mg%1:27:00:: | definition=a light silver-white ductile bivalent metallic element; in pure form it burns with brilliant white flame; occurs naturally only in combination (as in magnesite and dolomite and carnallite and spinel and olivine) | synonyms=magnesium, atomic number 12

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
**Analyzing the Meaning of "mg" in a Medical Context**

Okay, so the target is "mg" and it's within the sentence "The recommended dose of Alimta is 500 mg per square metre of body surface area...". Let's dissect this. We have two candidate senses here: "milligram" and "magnesium." Now, in my experience, in a medical setting, particularly when discussing drug dosages like Alimta, we're almost always dealing with units of weight. It's about quantifying the amount of the drug the patient is receiving. Dose is a quantity.

Thinking about it this way, "milligram," representing one-thousandth of a gram, perfectly fits the bill. It's a unit of mass, the common measurement for medication. "Magnesium," a metallic element, would be completely off-base in this context. While important in its own right, it's irrelevant to the dosage of a pharmaceutical compound. Therefore, based on the context of drug dosing, it's clear that the intended meaning of "mg" here is "milligram."


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: body
Target surface form: body
Context:
Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of <t>body</t> surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes.

Candidate senses:
1. sense_key=body%1:08:00:: | definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
2. sense_key=body%1:14:00:: | definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium; the student body
3. sense_key=body%1:08:02:: | definition=a natural object consisting of a dead animal or person | synonyms=dead body | examples=they found the body in the lake
4. sense_key=body%1:17:00:: | definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. sense_key=body%1:08:01:: | definition=the body excluding the head and neck and limbs | synonyms=torso, trunk | examples=they moved their arms and legs and bodies
6. sense_key=body%1:14:02:: | definition=a collection of particulars considered as a system | examples=a body of law; a body of doctrine
7. sense_key=body%1:07:00:: | definition=the property of holding together and retaining its shape | synonyms=consistency, consistence, eubstance | examples=wool has more body than rayon; when the dough has enough consistency it is ready to bake
8. sense_key=body%1:10:00:: | definition=the central message of a communication | examples=the body of the message was short
9. sense_key=body%1:07:01:: | definition=the main mass of a thing
10. sense_key=body%1:06:01:: | definition=a resonating chamber in a musical instrument (as the body of a violin) | synonyms=soundbox
11. sense_key=body%1:06:00:: | definition=the external structure of a vehicle | examples=the body of the car was badly rusted

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Meaning of "Body" in This Medical Context**

Okay, so the target word is "body," and the surrounding text is about Alimta dosage – specifically, how it's measured based on "body surface area." My initial thought is to identify the relevant sense of "body" here, given its multiple meanings. We've got a list of possible senses, which include the entire physical structure of an organism, a group of people, a deceased person, and a 3-dimensional object, along with the torso.

The phrase "body surface area" in this medical context *clearly* relates to the patient's physical being. When they're calculating a dosage based on someone's height and weight, they're talking about the external dimensions of their entire physical form. This means we're dealing with sense 1: the entire structure of an organism. No other sense even comes close to fitting. The focus is solely on the patient's physical attributes to make sure that the proper dose of the medicine is received.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: calculate
Target surface form: calculated
Context:
Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (<t>calculated</t> using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes.

Candidate senses:
1. sense_key=calculate%2:31:00:: | definition=make a mathematical calculation or computation | synonyms=cipher, cypher, compute, work out, reckon, figure
2. sense_key=calculate%2:31:03:: | definition=judge to be probable | synonyms=estimate, reckon, count on, figure, forecast
3. sense_key=calculate%2:40:00:: | definition=keep an account of | synonyms=account
4. sense_key=calculate%2:32:01:: | definition=predict in advance | synonyms=forecast
5. sense_key=calculate%2:31:02:: | definition=specifically design a product, event, or activity for a certain public | synonyms=aim, direct
6. sense_key=calculate%2:31:05:: | definition=have faith or confidence in | synonyms=count, bet, depend, look, reckon | examples=you can count on me to help you any time; Look to your friends for support

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**My Analysis of "Calculated" in Context**

Alright, let's break this down. The target word is "calculated," and the context is about determining the Alimta dosage based on a patient's body surface area. My initial thought process immediately focuses on the different senses of "calculate" within my semantic network. I quickly run through the possibilities.

I can immediately dismiss options like "judge to be probable," "keep an account of," "predict in advance," "specifically design a product," and "have faith or confidence in" because they don't seem to fit the scenario of determining a dosage.

Given the phrase "calculated using the patient's height and weight," I hone in on the first sense: "make a mathematical calculation or computation." That's the one. The body surface area is being *computed* using a formula that requires height and weight as inputs. It's a straightforward mathematical process, and that's the clear meaning in this context. No ambiguity here.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: using
Context:
Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated <t>using</t> the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes.

Candidate senses:
1. sense_key=use%2:34:01:: | definition=put into service; make work or employ for a particular purpose or for its inherent or natural purpose | synonyms=utilize, utilise, apply, employ | examples=use your head!; we only use Spanish at home
2. sense_key=use%2:34:02:: | definition=take or consume (regularly or habitually) | synonyms=habituate | examples=She uses drugs rarely
3. sense_key=use%2:34:00:: | definition=use up, consume fully | synonyms=expend | examples=The legislature expended its time on school questions
4. sense_key=use%2:41:14:: | definition=seek or achieve an end by using to one's advantage | examples=She uses her influential friends to get jobs; The president's wife used her good connections
5. sense_key=use%2:41:04:: | definition=avail oneself to | synonyms=practice, apply | examples=apply a principle; practice a religion
6. sense_key=use%2:41:03:: | definition=habitually do something (use only in the past tense) | examples=She used to call her mother every week but now she calls only occasionally; I used to get sick when I ate in that dining hall

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Verb "Using"**

Okay, so the target here is "use," specifically the "-ing" form: "using." The context is pretty straightforward: "calculated using the patient's height and weight." My initial thought is to run through the possible senses of "use" in my head – I have my usual list: put into service, consume, expend, leverage, apply, or even habitually do something.

Looking at the context, it's immediately clear that sense 1 is the winner. This is about calculation, and that means "put into service; make work or employ for a particular purpose." We're not consuming anything, or habitually doing anything, and it's not about advantage. The patient's height and weight are being **employed** in a calculation.

The synonyms, as expected, align perfectly: utilize, utilise, apply, and employ all work well. The context test seals the deal: "calculated utilizing the patient's height and weight" is perfect. Absolutely, sense 1 is the best fit. Case closed.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patient
Context:
Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the <t>patient</t> s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
**Analyzing the Context of "Patient"**

Okay, so I'm presented with "patient" as the lemma and "patient" as the surface form, and the surrounding text is "calculated using the patient's height and weight." This is within the context of Alimta, a cancer medication. My job is to determine the correct sense of "patient" in this instance.

The candidates I'm given are: 1) a person who requires medical care, and 2) the semantic role of an entity that isn't the agent. Given the medical context and the phrase referencing height and weight calculations, it's immediately clear that the intended meaning is **definitely** the first one. We're talking about the person undergoing treatment, not some abstract semantic role. It's a straightforward disambiguation.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: height
Target surface form: height
Context:
Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s <t>height</t> and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes.

Candidate senses:
1. sense_key=height%1:07:00:: | definition=the vertical dimension of extension; distance from the base of something to the top | synonyms=tallness
2. sense_key=height%1:26:00:: | definition=the highest level or degree attainable; the highest stage of development | synonyms=acme, elevation, peak, pinnacle, summit, superlative | examples=his landscapes were deemed the acme of beauty; the artist's gifts are at their acme
3. sense_key=height%1:07:01:: | definition=(of a standing person) the distance from head to foot | synonyms=stature
4. sense_key=height%1:07:02:: | definition=elevation especially above sea level or above the earth's surface | synonyms=altitude | examples=the altitude gave her a headache

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 3}
```

content:
```json
{"sense_index": 3}
```

reasoning_content:
**Analyzing the Word "Height" in Context**

Okay, so the lemma I'm working with is "height," and the surface form is, unsurprisingly, also "height." The context here is a clinical one; specifically, it's about calculating body surface area and mentions the patient's "height and weight." Right away, I'm thinking we're dealing with the physical dimension of a person. Now, let's break down the senses.

We've got Sense 1, which is the general vertical dimension – the literal *height* of an object. Then there’s Sense 2, the abstract “highest level or degree.” Sense 4, which is about elevation, especially above sea level. This is not likely the correct sense. That leaves Sense 3: the distance from head to foot of a standing person. (And they even give us the synonym "stature," which is helpful.)

Given the clinical context and the mention of weight, it's clear we're dealing with the patient's physical measurement. I'm going with Sense 3: the person's distance from head to foot, their overall stature. The context is perfectly aligned with this interpretation.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: weight
Target surface form: weight
Context:
Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and <t>weight</t>). It is given once every three weeks as an intravenous infusion lasting 10 minutes.

Candidate senses:
1. sense_key=weight%1:07:00:: | definition=the vertical force exerted by a mass as a result of gravity
2. sense_key=weight%1:06:01:: | definition=sports equipment used in calisthenic exercises and weightlifting; it is not attached to anything and is raised and lowered by use of the hands and arms | synonyms=free weight, exercising weight
3. sense_key=weight%1:07:01:: | definition=the relative importance granted to something | synonyms=weightiness | examples=his opinion carries great weight; the progression implied an increasing weightiness of the items listed
4. sense_key=weight%1:06:00:: | definition=an artifact that is heavy
5. sense_key=weight%1:12:00:: | definition=an oppressive feeling of heavy force | examples=bowed down by the weight of responsibility
6. sense_key=weight%1:23:01:: | definition=a system of units used to express the weight of something | synonyms=system of weights
7. sense_key=weight%1:23:00:: | definition=a unit used to measure weight | synonyms=weight unit | examples=he placed two weights in the scale pan
8. sense_key=weight%1:23:02:: | definition=(statistics) a coefficient assigned to elements of a frequency distribution in order to represent their relative importance | synonyms=weighting

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Nuances of "Weight" in a Medical Context**

Okay, so the task is to pinpoint the correct meaning of "weight" in this Alimta dosage description. My first instinct is to zero in on the physical property of body mass, given it's coupled with "height." Let's see, what does my knowledge base have? Ah, "weight%1:07:00::" seems spot on – it's the "vertical force exerted by a mass as a result of gravity," which aligns perfectly with how we measure a patient's size for medication dosage.

I'll quickly scan the other senses just to be thorough. We have sports equipment ("weight%1:06:01::"), importance ("weight%1:07:01::"), a heavy artifact ("weight%1:06:00::"), an oppressive feeling ("weight%1:12:00::"), units ("weight%1:23:01::"), and some statistical concepts ("weight%1:23:00::", "weight%1:23:02::"). Those are clearly irrelevant. The phrase "patient's height and weight" is unambiguously referring to the patient's physical body weight, as in sense 1. So, after a quick review, I'm confident that "weight%1:07:00::" is the appropriate sense here, as it encapsulates the actual quantity being used for the dosage calculation.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: give
Target surface form: given
Context:
Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is <t>given</t> once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta.

Candidate senses:
1. sense_key=give%2:40:03:: | definition=cause to have, in the abstract sense or physical sense | examples=She gave him a black eye; The draft gave me a cold
2. sense_key=give%2:40:05:: | definition=be the cause or source of | synonyms=yield, afford | examples=He gave me a lot of trouble; Our meeting afforded much interesting information
3. sense_key=give%2:40:00:: | definition=transfer possession of something concrete or abstract to somebody | examples=I gave her my money; can you give me lessons?
4. sense_key=give%2:40:07:: | definition=convey or reveal information | examples=Give one's name
5. sense_key=give%2:32:01:: | definition=convey, as of a compliment, regards, attention, etc.; bestow | synonyms=pay | examples=Don't pay him any mind; give the orders
6. sense_key=give%2:36:02:: | definition=organize or be responsible for | synonyms=hold, throw, have, make | examples=hold a reception; have, throw, or make a party
7. sense_key=give%2:32:00:: | definition=convey or communicate; of a smile, a look, a physical gesture | synonyms=throw | examples=Throw a glance; She gave me a dirty look
8. sense_key=give%2:40:01:: | definition=give as a present; make a gift of | synonyms=gift, present | examples=What will you give her for her birthday?
9. sense_key=give%2:36:03:: | definition=cause to happen or be responsible for | synonyms=yield | examples=His two singles gave the team the victory
10. sense_key=give%2:31:02:: | definition=dedicate | synonyms=pay, devote | examples=give thought to; give priority to
11. sense_key=give%2:36:00:: | definition=give or supply | synonyms=render, yield, return, generate | examples=The cow brings in 5 liters of milk; This year's crop yielded 1,000 bushels of corn
12. sense_key=give%2:40:09:: | definition=transmit (knowledge or skills) | synonyms=impart, leave, pass on | examples=give a secret to the Russians; leave your name and address here
13. sense_key=give%2:36:01:: | definition=bring about | synonyms=establish | examples=The trompe l'oeil-illusion establishes depth
14. sense_key=give%2:40:02:: | definition=leave with; give temporarily | examples=Can I give you my keys while I go in the pool?; Can I give you the children for the weekend?
15. sense_key=give%2:41:00:: | definition=emit or utter | examples=Give a gulp; give a yelp
16. sense_key=give%2:40:10:: | definition=endure the loss of | synonyms=sacrifice | examples=He gave his life for his children; I gave two sons to the war
17. sense_key=give%2:40:06:: | definition=place into the hands or custody of | synonyms=pass, hand, reach, pass on, turn over | examples=hand me the spoon, please; Turn the files over to me, please
18. sense_key=give%2:32:03:: | definition=give entirely to a specific person, activity, or cause | synonyms=dedicate, consecrate, commit, devote | examples=She committed herself to the work of God; give one's talents to a good cause
19. sense_key=give%2:40:13:: | definition=give (as medicine) | examples=I gave him the drug
20. sense_key=give%2:40:14:: | definition=give or convey physically | synonyms=apply | examples=She gave him First Aid; I gave him a punch in the nose
21. sense_key=give%2:32:02:: | definition=bestow | synonyms=render | examples=give homage; render thanks
22. sense_key=give%2:40:11:: | definition=bestow, especially officially | synonyms=grant | examples=grant a degree; give a divorce
23. sense_key=give%2:38:00:: | definition=move in order to make room for someone for something | synonyms=move over, give way, ease up, yield | examples=The park gave way to a supermarket; `Move over,' he told the crowd
24. sense_key=give%2:34:00:: | definition=give food to | synonyms=feed | examples=Feed the starving children in India; don't give the child this tough meat
25. sense_key=give%2:40:08:: | definition=contribute to some cause | synonyms=contribute, chip in, kick in | examples=I gave at the office
26. sense_key=give%2:38:13:: | definition=break down, literally or metaphorically | synonyms=collapse, fall in, cave in, give way, break, founder | examples=The wall collapsed; The business collapsed
27. sense_key=give%2:31:00:: | definition=estimate the duration or outcome of something | examples=He gave the patient three months to live; I gave him a very good chance at success
28. sense_key=give%2:41:10:: | definition=execute and deliver | examples=Give bond
29. sense_key=give%2:40:12:: | definition=deliver in exchange or recompense | examples=I'll give you three books for four CDs
30. sense_key=give%2:40:15:: | definition=afford access to | synonyms=afford, open | examples=the door opens to the patio; The French doors give onto a terrace
31. sense_key=give%2:36:13:: | definition=present to view | examples=He gave the sign to start
32. sense_key=give%2:36:12:: | definition=perform for an audience | examples=Pollini is giving another concert in New York
33. sense_key=give%2:35:00:: | definition=be flexible under stress of physical force | synonyms=yield | examples=This material doesn't give
34. sense_key=give%2:34:10:: | definition=propose | examples=He gave the first of many toasts at the birthday party
35. sense_key=give%2:32:11:: | definition=accord by verdict | examples=give a decision for the plaintiff
36. sense_key=give%2:32:08:: | definition=manifest or show | examples=This student gives promise of real creativity; The office gave evidence of tampering
37. sense_key=give%2:32:15:: | definition=offer in good faith | examples=He gave her his word
38. sense_key=give%2:32:14:: | definition=submit for consideration, judgment, or use | examples=give one's opinion; give an excuse
39. sense_key=give%2:32:09:: | definition=guide or direct, as by behavior of persuasion | examples=You gave me to think that you agreed with me
40. sense_key=give%2:32:07:: | definition=allow to have or take | examples=I give you two minutes to respond
41. sense_key=give%2:32:10:: | definition=inflict as a punishment | examples=She gave the boy a good spanking; The judge gave me 10 years
42. sense_key=give%2:30:13:: | definition=occur | examples=what gives?
43. sense_key=give%2:29:11:: | definition=consent to engage in sexual intercourse with a man | examples=She gave herself to many men
44. sense_key=give%2:29:10:: | definition=proffer (a body part) | examples=She gave her hand to her little sister

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 19}
```

reasoning_content:
**Analyzing the Word "Given" in a Medical Context**

Okay, the target word is "given," and the context mentions an intravenous infusion of "Alimta," which I immediately recognize as a chemotherapy medicine. My first thought is to quickly check the definition of "give" because this is obviously a medical context. I need to make sure I am on the right track. My intuition is that this usage will be a close one, but to be sure, I review the definitions I have access to. Aha! Sense 19: "give (as medicine) - 'I gave him the drug'." That perfectly aligns with the sentence, "It is given... as an intravenous infusion." It's a textbook match.

To be extra certain, I need to check the remaining text. "The medicine can only be obtained with a prescription." "Alimta should only be given under the supervision of a doctor..." and the original sentence, "It is given once every three weeks as an intravenous infusion..." Yes, all those usages point squarely to sense 19. It's a clean and definitive match. No ambiguity here.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: once
Target surface form: once
Context:
Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given <t>once</t> every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta.

Candidate senses:
1. sense_key=once%4:02:00:: | definition=on one occasion | synonyms=one time, in one case | examples=once I ran into her
2. sense_key=once%4:02:02:: | definition=as soon as | examples=once we are home, we can rest
3. sense_key=once%4:02:01:: | definition=at a previous time | synonyms=formerly, at one time, erstwhile, erst | examples=at one time he loved her; her erstwhile writing

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Deconstructing "Once" in Context**

Alright, let's break this down. The target word is "once," and the surrounding text is crucial: "It is given once every three weeks as an intravenous infusion lasting 10 minutes." My immediate thought is, what are the nuances here? We're dealing with "once" in the context of frequency.

Okay, let's explore the definitions. I'm seeing a few options. We have "on one occasion," which seems promising. There's also "as soon as," which is clearly irrelevant, and "at a previous time," which is also not the right fit here.

Looking at "once" as "on one occasion" or "one time" definitely clicks. The phrase "once every three weeks" screams frequency. It's happening *one time* within each three-week cycle. So, definition 1 is the winner. The phrase indicates a singular administration event within that specified timeframe. Case closed.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: every
Target surface form: every
Context:
Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once <t>every</t> three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta.

Candidate senses:
1. sense_key=every%5:00:00:all:00 | definition=(used of count nouns) each and all of the members of a group considered singly and without exception | examples=every person is mortal; every party is welcome
2. sense_key=every%5:00:02:all:00 | definition=each and all of a series of entities or intervals as specified | examples=every third seat; every two hours

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
**Analyzing "Every" in Context**

Okay, so the target is "every," and thankfully, the surface form matches the lemma. The context is "It is given once every three weeks as an intravenous infusion lasting 10 minutes." My initial task is to identify the applicable sense. There are two likely candidates: the first being the typical 'each and all' sense, applying to individual members of a group, and the second, which is about a specified interval or series.

Considering the surrounding text, the phrase "every three weeks" is clearly referring to a temporal interval. This automatically leads me to sense 2. The example "every two hours" is a perfect parallel; the meaning is fundamentally the same. The interpretation of "every" here, is that the infusion is given at an interval of three weeks between infusions. Therefore, I'm confident that sense 2 is the correct one in this specific context.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: week
Target surface form: weeks
Context:
Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three <t>weeks</t> as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta.

Candidate senses:
1. sense_key=week%1:28:00:: | definition=any period of seven consecutive days | synonyms=hebdomad | examples=it rained for a week
2. sense_key=week%1:28:01:: | definition=hours or days of work in a calendar week | synonyms=workweek | examples=they worked a 40-hour week
3. sense_key=week%1:28:02:: | definition=a period of seven consecutive days starting on Sunday | synonyms=calendar week

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
**Deconstructing "Weeks" in a Medical Context**

Okay, so the word "weeks" is the key here, specifically in the phrase "every three weeks" concerning an intravenous infusion. My expertise tells me I need to be precise. Let's break down the possible meanings.

First, we have the most general sense, Sense 1: simply a period of seven consecutive days. Like, "It rained for a week." Simple enough.

Then, there's Sense 2, referring to a workweek, the hours or days dedicated to work within a calendar week. We could say "a workweek."

Finally, Sense 3 is the calendar week, starting on Sunday.

Given the medical context of dosage frequency, "every three weeks" doesn't necessarily mean three calendar weeks starting on Sunday, nor a 3-week "workweek." Therefore, the correct interpretation has to be the most basic and flexible: Sense 1, a period of twenty-one consecutive days. This provides the most clarity and accuracy in this case.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: infusion
Target surface form: infusion
Context:
Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous <t>infusion</t> lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta.

Candidate senses:
1. sense_key=infusion%1:27:00:: | definition=a solution obtained by steeping or soaking a substance (usually in water) | synonyms=extract
2. sense_key=infusion%1:22:00:: | definition=the process of extracting certain active properties (as a drug from a plant) by steeping or soaking (usually in water)
3. sense_key=infusion%1:04:00:: | definition=(medicine) the passive introduction of a substance (a fluid or drug or electrolyte) into a vein or between tissues (as by gravitational force)
4. sense_key=infusion%1:04:01:: | definition=the act of infusing or introducing a certain modifying element or quality | examples=the team's continued success is attributable to a steady infusion of new talent

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 3}
```

reasoning_content:
**Analyzing the Term "Infusion" in a Medical Context**

Okay, so I'm looking at this medical context: "given once every three weeks as an intravenous infusion lasting 10 minutes." The key term here is "infusion," and I need to hone in on the precise meaning. Let's see...

Candidate 3 jumps out immediately. It's: `sense_key=infusion%1:04:00:: | definition=(medicine) the passive introduction of a substance (a fluid or drug or electrolyte) into a vein or between tissues (as by gravitational force)`. This aligns *perfectly* with the phrase "intravenous infusion" in the text. The definition emphasizes the passive nature, the introduction of a substance, and the venous route. The "10 minutes" duration also suggests a carefully administered process, not a quick extraction or simple steeping.

While the other candidates are relevant in *some* contexts, they just don't fit here:

*   Candidate 1, "solution obtained by steeping," is way off-base. Steeping is a different process entirely.
*   Candidate 2, "process of extracting," could fit in general terms, but not in this very specific context.
*   Candidate 4, "act of infusing a modifying element," is closer, but it's too general. It doesn't pinpoint the medical application with the precision of Candidate 3.

Therefore, the medical definition in Candidate 3 is the only realistic match. This patient is undergoing an intravenous infusion, likely receiving medication or fluids directly into their bloodstream over a short period.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: last
Target surface form: lasting
Context:
Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past. The medicine can only be obtained with a prescription. How is Alimta used? Alimta should only be given under the supervision of a doctor who is qualified in the use of anticancer chemotherapy. The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion <t>lasting</t> 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta.

Candidate senses:
1. sense_key=last%2:42:00:: | definition=persist for a specified period of time | synonyms=endure | examples=The bad weather lasted for three days
2. sense_key=last%2:42:01:: | definition=continue to live through hardship or adversity | synonyms=survive, live, live on, go, endure, hold up | examples=We went without water and food for 3 days; These superstitions survive in the backwaters of America

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
**Analyzing the Semantic Nuances of "Lasting"**

Alright, let's break this down. The core word is "lasting," derived from "last." My expertise immediately kicks in to identify the pertinent sense within this specific context. We've got two candidate senses flagged by the lexical resources: the duration sense – "persist for a specified period of time" – and the survival sense – "continue to live through hardship."

The context is crucial here: "It is given once every three weeks as an intravenous infusion lasting 10 minutes." The phrase "lasting 10 minutes" clearly indicates a duration. It’s measuring the time the infusion *persists*. Therefore, the first sense, "persist for a specified period of time," is the definitive match. It's a straightforward application of the temporal understanding of "last," no need to overthink it. This is a clear case of duration being the intended meaning.