[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: kill
Target surface form: kills
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=kill%2:35:00:: | definition=cause to die; put to death, usually intentionally or knowingly | examples=This man killed several people when he tried to rob a bank; The farmer killed a pig for the holidays
2. sense_key=kill%2:41:01:: | definition=thwart the passage of | synonyms=shoot down, defeat, vote down, vote out | examples=kill a motion; he shot down the student's proposal
3. sense_key=kill%2:30:08:: | definition=end or extinguish by forceful means | synonyms=stamp out | examples=Stamp out poverty!
4. sense_key=kill%2:42:00:: | definition=be fatal | examples=cigarettes kill; drunken driving kills
5. sense_key=kill%2:39:00:: | definition=be the source of great pain for | examples=These new shoes are killing me!
6. sense_key=kill%2:37:00:: | definition=overwhelm with hilarity, pleasure, or admiration | examples=The comedian was so funny, he was killing me!
7. sense_key=kill%2:35:06:: | definition=hit with so much force as to make a return impossible, in racket games | examples=She killed the ball
8. sense_key=kill%2:35:05:: | definition=hit with great force | examples=He killed the ball
9. sense_key=kill%2:35:02:: | definition=deprive of life | examples=AIDS has killed thousands in Africa
10. sense_key=kill%2:35:01:: | definition=cause the death of, without intention | examples=She was killed in the collision of three cars
11. sense_key=kill%2:34:00:: | definition=drink down entirely | synonyms=toss off, pop, bolt down, belt down, pour down, down | examples=He downed three martinis before dinner; She killed a bottle of brandy that night
12. sense_key=kill%2:30:00:: | definition=mark for deletion, rub off, or erase | synonyms=obliterate, wipe out | examples=kill these lines in the President's speech
13. sense_key=kill%2:30:04:: | definition=tire out completely | examples=The daily stress of her work is killing her
14. sense_key=kill%2:30:03:: | definition=cause to cease operating | examples=kill the engine
15. sense_key=kill%2:30:02:: | definition=destroy a vitally essential quality of or in | examples=Eating artichokes kills the taste of all other foods

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are asked to choose the best sense for "kills" in the context: "a medicine that kills cells that are dividing, such as cancer cells". We have 15 candidate senses with definitions and examples. The target word is "kills", referring to the action of a medicine on cells. The medicine is cytotoxic, meaning it kills cells. The context specifies "cells that are dividing, such as cancer cells". So we need a sense that means causing cells to die, specifically by a chemical substance. Let's analyze the senses:

1. cause to die; put to death, usually intentionally or knowingly. Examples: This man killed several people... The farmer killed a pig. This implies an intentional act by an agent (person). But here the subject is a medicine, not a person. Could fit if we consider the medicine as the causer, but the examples are all about human agents.

2. thwart the passage of (like vote down). Not relevant.

3. end or extinguish by forceful means; stamp out. Example: Stamp out poverty! Metaphorical, not literal killing of cells.

4. be fatal. Example: cigarettes kill; drunken driving kills. This sense is intransitive? "cigarettes kill" means they cause death, but it's a general statement. Here the construction is "a medicine that kills cells" – it's transitive, with an object. Sense 4 might be used without an object (e.g., "Smoking kills"), but it's defined as "be fatal", so it could be like "cigarettes kill" meaning cigarettes are a cause of death. However, in our sentence, "kills cells" is clearly transitive, so sense 4 might not fit exactly because it's more about causing death in general rather than killing specific entities.

5. be the source of great pain for. Not appropriate.

6. overwhelm with hilarity. Not.

7,8: hit with force (in racket games). Not.

9. deprive of life. Example: AIDS has killed thousands in Africa. AIDS is a disease, an abstract cause, not a person. So this sense is about causing death, often by disease or impersonal force. The subject is "AIDS", which is similar to "medicine". So sense 9: "deprive of life". That fits: a medicine that deprives cells of life. It's transitive and can be used with an impersonal agent.

10. cause the death of, without intention. Example: She was killed in the collision. Passive, or accidental. Our context is intentional (the medicine is designed to kill cells), so not exactly without intention, but the medicine itself doesn't have intention; it's a tool. Sense 10 is about unintentional killing where the subject is often an event or accident. But here the killing is the intended effect. So sense 10 might not be best.

11. drink down entirely. Not.

12. mark for deletion. Not.

13. tire out completely. Not.

14. cause to cease operating (like kill an engine). Not applicable to cells.

15. destroy a vitally essential quality of or in. Example: Eating artichokes kills the taste of all other foods. Metaphorical, not literal killing.

So the main candidates are 1, 9, and possibly 4. Compare 1 and 9. Sense 1: "cause to die; put to death, usually intentionally or knowingly". The examples involve human agents doing intentional killing. Sense 9: "deprive of life", with example "AIDS has killed thousands in Africa". This is more impersonal, and often used for things like diseases, drugs, etc. In medical contexts, we say "chemotherapy kills cancer cells". So sense 9 seems more appropriate because the subject is a medicine/drug, like AIDS, rather than a person. Sense 1 is more for intentional killing by a person. Also, note the syntax: "a medicine that kills cells" – the medicine is the agent, so it's an inanimate cause. WordNet often differentiates between intentional murder (1) and causing death by disease/accident (9). Indeed, in WordNet, sense 1 is often used for people killing, while sense 9 is for anything that deprives of life. Sense 10 is accidental death. So I'll choose sense 9.

Check: The context says "cytotoxic medicine (a medicine that kills cells)". So it's the action of a substance causing cell death. That matches sense 9.

Thus, the answer is sense_index 9.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cells
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

finish_reason: stop

role: assistant

reasoning_content:
We are asked to perform word sense disambiguation for the lemma "cell" with surface form "cells" in the given context. The candidate senses are listed with sense indices 1 through 7. We need to choose the most appropriate sense based on the context.

Context: "Alimta ... pemetrexed is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells) ... nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

Clearly, the word "cells" here refers to biological cells—the basic structural and functional unit of living organisms. Sense 2 matches: "cell%1:03:00:: definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals". The context explicitly mentions "cancer cells" and "genetic material of cells", which are biological.

No other sense fits: sense 1 (compartments like honeycomb), sense 3 (electric cell), sense 4 (political movement), sense 5 (mobile phone), sense 6 (monk's room), sense 7 (prison cell). All are clearly inappropriate.

Thus, the correct indexed sense is 2.

Return JSON: {"sense_index": 2}

format: unknown

native_finish_reason: stop

provider: Baidu

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: divide
Target surface form: dividing
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=divide%2:41:00:: | definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire after World War I
2. sense_key=divide%2:31:00:: | definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven?
3. sense_key=divide%2:42:00:: | definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries
4. sense_key=divide%2:35:00:: | definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated
5. sense_key=divide%2:38:00:: | definition=make a division or separation | synonyms=separate
6. sense_key=divide%2:35:01:: | definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are given a target lemma "divide" with target surface form "dividing" in a specific context. The context is about Alimta, a cytotoxic medicine that kills cells that are dividing, such as cancer cells. So the cells are in the process of dividing, meaning cell division (mitosis). We need to choose the best WordNet sense for "divide" here.

Let's examine the candidate senses:

1. sense_key=divide%2:41:00:: | definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire after World War I
This is about dividing objects or territories into parts.

2. sense_key=divide%2:31:00:: | definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven?
This is mathematical division.

3. sense_key=divide%2:42:00:: | definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries
This is about serving as a boundary.

4. sense_key=divide%2:35:00:: | definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated
This is intransitive: things come apart.

5. sense_key=divide%2:38:00:: | definition=make a division or separation | synonyms=separate
This is a bit vague: "make a division or separation". It might apply to cells dividing.

6. sense_key=divide%2:35:01:: | definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea
This is transitive: forcing things apart.

Now, in the context: "cells that are dividing" - this is a biological process where a cell divides into two daughter cells. This is a form of coming apart or splitting. However, sense 4 is "come apart" and is intransitive, which fits "cells that are dividing" (cells themselves come apart). Sense 1 is transitive "separate into parts or portions", typically with an agent. But cells dividing is often considered an intransitive process. Let's check WordNet for biological cell division. Usually, there is a specific sense for "divide" in biology: "reproduce by division" (e.g., bacteria divide). However, in the given candidates, we don't have that exact sense. The closest might be sense 4: "come apart". But note that in cell division, the cell doesn't just come apart; it actively divides into two. There might be an implicit sense: "to split into two or more parts" which is intransitive. Sense 4 says "come apart", which could be synonymous with "split". However, the example "The two pieces that we had glued separated" is about previously joined things coming apart. Cells dividing is a bit more active: they split into new cells. But in common usage, "cells divide" uses the intransitive sense.

Let's look at the definition of sense 5: "make a division or separation". That could be both transitive and intransitive? The definition is vague. It might be the sense used for cells. Actually, in many dictionaries, the biological sense is often defined as "to undergo cell division" or "to split into parts". In WordNet, there might be a specific sense for "divide" as "reproduce by division" (like for cells). But it's not listed here. Among the given, sense 4 "come apart" is the only intransitive one that doesn't require a sentient agent. Sense 1 is transitive with an agent dividing something. Sense 2 is math. Sense 3 is about standing between. Sense 5 is ambiguous. Sense 6 is transitive.

Given the context "cells that are dividing", we need an intransitive sense meaning "to undergo division". Sense 4 "come apart" fits that. Also, the synonyms for sense 4 are "separate, part". That could describe cells dividing.

But let's double-check: is there a better sense? The sentence: "kills cells that are dividing, such as cancer cells". Cancer cells are actively dividing (undergoing mitosis). The process is cell division. So the cells divide (intransitive). So I'd go with sense 4.

Thus, the answer is {"sense_index": 4}.

provider: Novita


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: body
Target surface form: body
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=body%1:08:00:: | definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
2. sense_key=body%1:14:00:: | definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium; the student body
3. sense_key=body%1:08:02:: | definition=a natural object consisting of a dead animal or person | synonyms=dead body | examples=they found the body in the lake
4. sense_key=body%1:17:00:: | definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. sense_key=body%1:08:01:: | definition=the body excluding the head and neck and limbs | synonyms=torso, trunk | examples=they moved their arms and legs and bodies
6. sense_key=body%1:14:02:: | definition=a collection of particulars considered as a system | examples=a body of law; a body of doctrine
7. sense_key=body%1:07:00:: | definition=the property of holding together and retaining its shape | synonyms=consistency, consistence, eubstance | examples=wool has more body than rayon; when the dough has enough consistency it is ready to bake
8. sense_key=body%1:10:00:: | definition=the central message of a communication | examples=the body of the message was short
9. sense_key=body%1:07:01:: | definition=the main mass of a thing
10. sense_key=body%1:06:01:: | definition=a resonating chamber in a musical instrument (as the body of a violin) | synonyms=soundbox
11. sense_key=body%1:06:00:: | definition=the external structure of a vehicle | examples=the body of the car was badly rusted

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We are given a sentence with the target word "body" in context: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides..." The context is clearly referring to the human body, as it talks about how the drug works inside the body. Among the candidate senses, sense 1: "the entire structure of an organism (an animal, plant, or human being)" fits perfectly. The example even mentions "he felt as if his whole body were on fire", which is about a human body. Other senses like dead body, torso, group of persons, etc., are not relevant. So the best sense index is 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: convert
Target surface form: converted
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=convert%2:30:00:: | definition=change from one system to another or to a new plan or policy | synonyms=change over | examples=We converted from 220 to 110 Volt
2. sense_key=convert%2:30:03:: | definition=change the nature, purpose, or function of something | examples=convert lead into gold; convert hotels into jails
3. sense_key=convert%2:30:01:: | definition=change religious beliefs, or adopt a religious belief | examples=She converted to Buddhism
4. sense_key=convert%2:30:02:: | definition=exchange or replace with another, usually of the same kind or category | synonyms=change, exchange, commute | examples=Could you convert my dollars into pounds?; He changed his name
5. sense_key=convert%2:30:07:: | definition=cause to adopt a new or different faith | examples=The missionaries converted the Indian population
6. sense_key=convert%2:33:02:: | definition=score an extra point or points after touchdown by kicking the ball through the uprights or advancing the ball into the end zone | examples=Smith converted and his team won
7. sense_key=convert%2:33:01:: | definition=complete successfully | examples=score a penalty shot or free throw
8. sense_key=convert%2:33:00:: | definition=score (a spare)
9. sense_key=convert%2:32:00:: | definition=make (someone) agree, understand, or realize the truth or validity of something | synonyms=win over, convince | examples=He had finally convinced several customers of the advantages of his product
10. sense_key=convert%2:30:09:: | definition=exchange a penalty for a less severe one | synonyms=commute, exchange
11. sense_key=convert%2:30:04:: | definition=change in nature, purpose, or function; undergo a chemical change | examples=The substance converts to an acid

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are given: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?"

We need to choose the best sense for "converted". The context is scientific: a drug (pemetrexed) is converted into an active form in the body. This is a biochemical transformation. Looking at the candidate senses:

1. convert%2:30:00:: change from one system to another or to a new plan or policy. Examples: "We converted from 220 to 110 Volt". Not suitable; not about a substance transformation.

2. convert%2:30:03:: change the nature, purpose, or function of something. Examples: "convert lead into gold; convert hotels into jails". This could work, but it's about changing something into something else, often with a different purpose. However, the context is chemical change: pemetrexed becomes an active form. The sense might be more about a chemical conversion.

3. convert%2:30:01:: change religious beliefs - clearly not.

4. convert%2:30:02:: exchange or replace with another, usually of the same kind or category. Examples: "Could you convert my dollars into pounds?" Not chemical.

5. convert%2:30:07:: cause to adopt a new or different faith - not.

6. convert%2:33:02:: football - not.

7. convert%2:33:01:: sports - not.

8. convert%2:33:00:: bowling - not.

9. convert%2:32:00:: convince - not.

10. convert%2:30:09:: exchange a penalty - not.

11. convert%2:30:04:: change in nature, purpose, or function; undergo a chemical change. Examples: "The substance converts to an acid". This is exactly the sense: a substance undergoes a chemical change. The definition says "undergo a chemical change", and the example is directly relevant. The gloss: "change in nature, purpose, or function; undergo a chemical change". This matches the context: pemetrexed is converted into an active form. That is a chemical change in the body.

Sense 2 is "change the nature, purpose, or function of something", but it's transitive: someone changes something. Sense 11 is intransitive or reflexive: "undergo a chemical change". However, in the sentence "pemetrexed is converted into an active form", it's passive, meaning it undergoes conversion. Sense 11 fits perfectly.

The instructions say: WordNet glosses are schematic; use the context, synonyms, and examples. Sense 11 explicitly mentions "undergo a chemical change" and the example is about a substance converting to an acid. So sense_index 11 is correct.

Thus, answer: {"sense_index":

provider: DigitalOcean


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
7. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
13. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are asked to disambiguate the word "active" in the given context. The target sentence: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes..." So, we need to find which sense of "active" fits best.

Let's examine the candidate senses:

1. "tending to become more severe or wider in scope" — examples: "active tuberculosis". This doesn't fit because we're talking about a drug's active form, meaning it is biologically effective, not becoming more severe.

2. "engaged in or ready for military or naval operations" — clearly not.

3. "disposed to take action or effectuate change" — somewhat abstract, but could fit in a metaphorical sense? However, an "active form" of a drug is not about being disposed to take action; it's about being in a state where it can exert its effect. But let's see other candidates.

4. "taking part in an activity" — this is about participation. Not suitable for a chemical form.

5. "characterized by energetic activity" — like an active toddler. Not suitable.

6. "exerting influence or producing a change or effect" — example: "an active ingredient". This is very close. An active form of a drug is the form that exerts its biological effect. The example "active ingredient" is exactly the same context: a substance that produces an effect. So sense 6 seems perfect.

7. "full of activity or engaged in continuous activity" — e.g., "an active seaport". Not applicable.

8. "in operation" — synonyms: alive, e.g., "keep hope alive". Possibly, but more abstract. "Active form" is not just "in operation", it specifically means it has its effect. Sense 6 is more precise.

9. "of the sun..." no.

10. "expressing that the subject ... has the semantic function of actor" — linguistic sense. No.

11. "(used of verbs...)" — grammatical sense. No.

12. "(of e.g. volcanos) capable of erupting" — no.

13. "(of e.g. volcanos) erupting or liable to erupt" — no.

14. "engaged in full-time work" — no.

Clearly, sense 6 is the one: "exerting influence or producing a change or effect" with the example "an active ingredient". In pharmacology, the "active form" of a drug is the one that produces the desired effect. So the answer is sense_index 6.

Return JSON: {"sense_index": 6}

provider: GMICloud


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: form
Target surface form: form
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=form%1:10:00:: | definition=the phonological or orthographic sound or appearance of a word that can be used to describe or identify something | synonyms=word form, signifier, descriptor | examples=the inflected forms of a word can be represented by a stem and a list of inflections to be attached
2. sense_key=form%1:09:01:: | definition=a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety | examples=sculpture is a form of art; what kinds of desserts are there?
3. sense_key=form%1:09:00:: | definition=a perceptual structure | synonyms=shape, pattern | examples=the composition presents problems for students of musical form; a visual pattern must include not only objects but the spaces between them
4. sense_key=form%1:07:01:: | definition=any spatial attributes (especially as defined by outline) | synonyms=shape, configuration, contour, conformation | examples=he could barely make out their shapes
5. sense_key=form%1:08:00:: | definition=alternative names for the body of a human being | synonyms=human body, physical body, material body, soma, build, figure | examples=Leonardo studied the human body; he has a strong physique
6. sense_key=form%1:03:00:: | definition=the spatial arrangement of something as distinct from its substance | synonyms=shape | examples=geometry is the mathematical science of shape
7. sense_key=form%1:07:00:: | definition=the visual appearance of something or someone | synonyms=shape, cast | examples=the delicate cast of his features
8. sense_key=form%1:10:01:: | definition=a printed document with spaces in which to write | examples=he filled out his tax form
9. sense_key=form%1:14:02:: | definition=(biology) a group of organisms within a species that differ in trivial ways from similar groups | synonyms=variant, strain, var. | examples=a new strain of microorganisms
10. sense_key=form%1:10:02:: | definition=an arrangement of the elements in a composition or discourse | examples=the essay was in the form of a dialogue; he first sketches the plot in outline form
11. sense_key=form%1:07:03:: | definition=a particular mode in which something is manifested | examples=his resentment took the form of extreme hostility
12. sense_key=form%1:26:00:: | definition=(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary | synonyms=phase | examples=the reaction occurs in the liquid phase of the system
13. sense_key=form%1:14:00:: | definition=a body of students who are taught together | synonyms=class, grade, course | examples=early morning classes are always sleepy
14. sense_key=form%1:07:02:: | definition=an ability to perform well | examples=he was at the top of his form; the team was off form last night
15. sense_key=form%1:06:00:: | definition=a life-size dummy used to display clothes | synonyms=mannequin, manikin, mannikin, manakin
16. sense_key=form%1:06:01:: | definition=a mold for setting concrete | examples=they built elaborate forms for pouring the foundation

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are given: Target word "form" with context: "In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes...". We need to choose the best sense among the 16 listed.

Let's analyze the context. The sentence: "pemetrexed is converted into an active form that blocks the activity of the enzymes". Here, "form" refers to a chemically active version or state of the drug. It is a particular molecular variant or version of the substance that has a specific activity. This is about a drug being metabolized into an active version. So "form" here means a particular variant or type of a substance with distinct properties. Looking at the candidate senses:

- Sense 2: "a category of things distinguished by some common characteristic or quality" (synonyms: kind, sort, variety). That could work: an active kind/variety of the drug. But is there a more specific sense?
- Sense 11: "a particular mode in which something is manifested" (examples: "his resentment took the form of extreme hostility"). That is about how something is manifested, but here it's about a chemical conversion to an active version, so it's more about a physical/chemical form.
- Sense 12: "(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary" (synonyms: phase). This is a technical chemistry sense: "phase". In the body, a drug can be converted into an active metabolite, which is a different chemical compound, not just a different phase. So "active form" might refer to a chemically modified version (e.g., a phosphorylated form). But is that necessarily a phase? Usually "form" in biochemistry can mean a molecular species, like an active form of a drug could be its metabolite. However, sense 12 specifies "distinct state of matter" and "phase boundary", which is more about solid, liquid, gas, etc. Not fitting here.
- Sense 9: "(biology) a group of organisms within a species that differ in trivial ways" - not relevant.
- Sense 10: "an arrangement of the elements in a composition or discourse" - not relevant.
- Many other senses about physical shape, appearance, etc., are not relevant.

The most fitting seems to be sense 2: kind, sort, variety. The drug is converted into an active kind. Alternatively, could it be sense 11: a particular mode in which something is manifested? The active form is the way the drug exists in an active state. That is close. But sense 2 is more about categories, and here it's specifically a type of the substance. Let's check the examples for sense 2: "sculpture is a form of art; what kinds of desserts are there?" That is broad. Sense 11: "his resentment took the form of extreme hostility" is about a manifestation, which might also fit: the drug takes the form of an active enzyme blocker. But I think sense 2 is more straightforward.

Is there a specific chemical sense that we should consider? The WordNet sense 12 (phase) is the only chemistry-related one, but it's not a great match. Often in biology/chemistry, "form" can refer to a specific molecular species, but WordNet might not have that. In context, "active form" is a common phrase meaning the active version of a drug. It's essentially a kind of the drug. So I'll go with sense 2.

But let's double-check: Could it be sense 11? "a particular mode in which something is manifested" — the active form is the mode in which the drug's activity is manifested. That also works. Which one is more precise? The phrase "converted into an active form" suggests the drug is transformed into a different chemical entity that is active. That entity is a "form" meaning a variant. In common usage, that's more like "kind". Sense 2 is "category of things distinguished by some common characteristic" — here, the characteristic is being active and able to block enzymes. So that fits. Sense 11's example uses "took the form of" which is more about a non-physical manifestation (resentment -> hostility). Here, it's a physical/chemical conversion. So sense 2 seems better.

I'll answer with sense_index: 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: block
Target surface form: blocks
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=block%2:35:00:: | definition=render unsuitable for passage | synonyms=barricade, blockade, stop, block off, block up, bar | examples=block the way; barricade the streets
2. sense_key=block%2:41:00:: | definition=hinder or prevent the progress or accomplishment of | synonyms=obstruct, blockade, hinder, stymie, stymy, embarrass | examples=His brother blocked him at every turn
3. sense_key=block%2:41:01:: | definition=stop from happening or developing | synonyms=stop, halt, kibosh | examples=Block his election; Halt the process
4. sense_key=block%2:32:00:: | definition=interfere with or prevent the reception of signals | synonyms=jam | examples=Jam the Voice of America; block the signals emitted by this station
5. sense_key=block%2:41:03:: | definition=run on a block system | examples=block trains
6. sense_key=block%2:39:05:: | definition=interrupt the normal function of by means of anesthesia | examples=block a nerve; block a muscle
7. sense_key=block%2:39:00:: | definition=shut out from view or get in the way so as to hide from sight | synonyms=obstruct | examples=The thick curtain blocked the action on the stage; The trees obstruct my view of the mountains
8. sense_key=block%2:35:03:: | definition=stamp or emboss a title or design on a book with a block | examples=block the book cover
9. sense_key=block%2:35:02:: | definition=obstruct | synonyms=stuff, lug, choke up | examples=My nose is all stuffed; Her arteries are blocked
10. sense_key=block%2:35:12:: | definition=block passage through | synonyms=obstruct, obturate, impede, occlude, jam, close up | examples=obstruct the path
11. sense_key=block%2:35:06:: | definition=support, secure, or raise with a block | examples=block a plate for printing; block the wheels of a car
12. sense_key=block%2:33:00:: | definition=impede the movement of (an opponent or a ball) | synonyms=parry, deflect | examples=block an attack
13. sense_key=block%2:31:00:: | definition=be unable to remember | synonyms=forget, blank out, draw a blank | examples=I'm drawing a blank; You are blocking the name of your first wife!
14. sense_key=block%2:30:01:: | definition=shape by using a block | examples=Block a hat; block a garment
15. sense_key=block%2:30:00:: | definition=shape into a block or blocks | examples=block the graphs so one can see the results clearly
16. sense_key=block%2:30:02:: | definition=prohibit the conversion or use of (assets) | synonyms=freeze, immobilize, immobilise | examples=Blocked funds; Freeze the assets of this hostile government

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are given the target word "blocks" in the context: "pemetrexed is converted into an active form that blocks the activity of the enzymes". The candidate senses are listed. We need to choose the best sense that matches the meaning of "blocks" in this biomedical context, where the active form of the drug inhibits enzyme activity.

Candidate senses:

1. render unsuitable for passage (e.g., block the way)
2. hinder or prevent progress (e.g., his brother blocked him)
3. stop from happening or developing (e.g., block his election; halt the process)
4. interfere with or prevent reception of signals (e.g., jam)
5. run on a block system (trains)
6. interrupt normal function by anesthesia
7. shut out from view
8. stamp/bookbinding
9. obstruct (nose stuffed)
10. block passage physically
11. support with a block
12. impede movement of opponent (sports)
13. forget
14. shape a hat
15. shape into a block
16. freeze assets

Sense 3: "stop from happening or developing" with synonyms stop, halt, kibosh. Example: "Block his election; Halt the process." This fits biochemical inhibition: the active form stops the activity of enzymes.
Sense 2: "hinder or prevent progress" also could fit, but sense 3 explicitly says "stop from happening or developing" which more directly matches blocking the activity of enzymes. Sense 2 is more about obstructing someone's progress, often with an animate subject and an effort. Sense 3 is more generic, about stopping a process.
Sense 6: interrupt normal function by means of anesthesia, but that is specifically for nerves or muscles. Here it's enzymes, which is not anesthesia but an antimetabolite. Sense 6 might be related but it's specific to medical procedures for nerves, not biochemical inhibition.

Given the context: "blocks the activity of the enzymes", we want "stop the activity" or "inhibit". The gloss for sense 3 is "stop from happening or developing" which works for activity. Examples: "Halt the process" - blocking enzyme activity means halting the enzymatic process. So sense 3 is best.

Thus, answer: {"sense_index": 3}.

provider: Together


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: involved
Target surface form: involved
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=involved%3:00:00:: | definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved; the problems involved
2. sense_key=involved%5:00:00:encumbered:00 | definition=entangled or hindered as if e.g. in mire | synonyms=mired | examples=the difficulties in which the question is involved; brilliant leadership mired in details and confusion
3. sense_key=involved%5:00:00:attached:01 | definition=emotionally involved
4. sense_key=involved%5:00:00:complex:00 | definition=highly complex or intricate and occasionally devious; ; ; ; ; ; ; ; - Sir Walter Scott | synonyms=Byzantine, convoluted, knotty, tangled, tortuous | examples=the Byzantine tax structure; Byzantine methods for holding on to his chairmanship
5. sense_key=involved%5:00:00:enclosed:00 | definition=enveloped | examples=a castle involved in mist; the difficulties in which the question is involved

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are asked to perform word sense disambiguation for the target word "involved" in the given context. The target lemma is "involved", surface form is "involved". The context is: "Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?"

The target word is "involved" in the phrase "enzymes that are involved in producing nucleotides". We need to pick the best sense from the five given.

Let's analyze each sense:

1. sense_key=involved%3:00:00:: | definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved; the problems involved
   This sense means being included or participating in something. In the context, enzymes are "involved in" producing nucleotides, meaning they participate in the process. This seems fitting.

2. sense_key=involved%5:00:00:encumbered:00 | definition=entangled or hindered as if e.g. in mire | synonyms=mired | examples=the difficulties in which the question is involved; brilliant leadership mired in details and confusion
   This sense means tangled or hindered, like being stuck. Not appropriate for enzymes participating in a process.

3. sense_key=involved%5:00:00:attached:01 | definition=emotionally involved
   This is about emotional involvement. Not appropriate for enzymes.

4. sense_key=involved%5:00:00:complex:00 | definition=highly complex or intricate and occasionally devious; ; ; ; ; ; ; ; - Sir Walter Scott | synonyms=Byzantine, convoluted, knotty, tangled, tortuous | examples=the Byzantine tax structure; Byzantine methods for holding on to his chairmanship
   This sense means convoluted or complex. Not appropriate here; the enzymes aren't described as complex, they are participating in a process.

5. sense_key=involved%5:00:00:enclosed:00 | definition=enveloped | examples=a castle involved in mist; the difficulties in which the question is involved
   This means enveloped or covered. Not appropriate.

Clearly, sense 1 is the correct one: "connected by participation or association or use". The phrase "enzymes that are involved in producing nucleotides" means enzymes that participate in the production.

Thus, the answer is {"sense_index": 1}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: produce
Target surface form: producing
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in <t>producing</t> nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=produce%2:36:02:: | definition=bring forth or yield | synonyms=bring forth | examples=The tree would not produce fruit
2. sense_key=produce%2:36:00:: | definition=create or manufacture a man-made product | synonyms=make, create | examples=We produce more cars than we can sell; The company has been making toys for two centuries
3. sense_key=produce%2:36:03:: | definition=cause to happen, occur or exist | synonyms=bring about, give rise | examples=This procedure produces a curious effect; The new law gave rise to many complaints
4. sense_key=produce%2:39:01:: | definition=bring out for display | synonyms=bring forth | examples=The proud father produced many pictures of his baby; The accused brought forth a letter in court that he claims exonerates him
5. sense_key=produce%2:36:05:: | definition=cultivate by growing, often involving improvements by means of agricultural techniques | synonyms=grow, raise, farm | examples=The Bordeaux region produces great red wines; They produce good ham in Parma
6. sense_key=produce%2:39:00:: | definition=bring onto the market or release | synonyms=bring on, bring out | examples=produce a movie; bring out a book
7. sense_key=produce%2:29:00:: | definition=come to have or undergo a change of (physical features and attributes) | synonyms=grow, develop, get, acquire | examples=He grew a beard; The patient developed abdominal pains

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are asked to perform word sense disambiguation for the target word "produce" in the given context. The context is about the mechanism of action of the drug Alimta (pemetrexed). Specifically, the sentence says: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

We need to choose the best sense from the given candidates. Let's analyze each sense in relation to the context.

Sense 1: "bring forth or yield" with examples like "The tree would not produce fruit." This is about natural yielding, often of plants or natural results.

Sense 2: "create or manufacture a man-made product" with examples like "We produce more cars than we can sell." This emphasizes manufacturing.

Sense 3: "cause to happen, occur or exist" with examples like "This procedure produces a curious effect." This is about causing an effect or result.

Sense 4: "bring out for display" like producing pictures or a letter. This doesn't fit.

Sense 5: "cultivate by growing" like producing wine or ham. This is agricultural, not relevant here.

Sense 6: "bring onto the market or release" like produce a movie or book. Not relevant.

Sense 7: "come to have or undergo a change of (physical features)" like growing a beard. Not relevant.

The context is about enzymes involved in "producing nucleotides". Nucleotides are molecules that are synthesized in cells through metabolic pathways. The enzymes are involved in the biosynthesis of nucleotides. It is a biological process where the enzymes catalyze reactions that result in the formation of nucleotides. This is not a man-made manufacturing, but a natural biochemical process. Sense 1 "bring forth or yield" can apply to natural yielding, but typically it's used for plants yielding fruit. However, nucleotides are "yielded" by enzymatic reactions. Sense 3 "cause to happen, occur or exist" also fits: the enzymes cause nucleotides to exist, they bring about the formation of nucleotides. The distinction: Sense 3 is more about causing an effect, while Sense 1 is about yielding something, often from a natural process. The example for Sense 3: "This procedure produces a curious effect" is about an abstract result. For a concrete product like nucleotides, Sense 1 might be more appropriate because it's about yielding a tangible substance. In biological contexts, "produce" often means to synthesize or generate a substance. WordNet sense 1 is "bring forth or yield", and its synonyms include "bring forth". It's often used for natural products. For instance, the body produces hormones. That fits well. Sense 2 is specifically "man-made", so not appropriate. Sense 3 is more about causing events or effects, less about yielding a substance. The gloss "cause to happen, occur or exist" could also include the existence of nucleotides. But typically, when talking about biochemical production of a molecule, sense 1 is used. Let's check the WordNet hierarchy: sense_key=produce%2:36:02:: is the second sense in the verb "produce" (if we index by frequency). In WordNet, sense ordering is by frequency. The given list has sense 1 with sense_key=produce%2:36:02::, which might be the most common sense? Actually, WordNet keys encode the sense number: the digits after the last colon are the sense number. produce%2:36:02:: means it's sense 2. In the provided candidates, they are numbered 1-7, but those numbers are just the list index, not the WordNet sense number. The sense_key is the identifier. So we need to pick the correct sense_key from the list. The question says: "Return only a JSON object exactly like {"sense_index": 3}." So we need to output the index from the list (1-7) that corresponds to the best sense.

Let's evaluate:

- Index 1: produce%2:36:02:: "bring forth or yield" – This seems most appropriate: enzymes yield nucleotides.
- Index 3: produce%2:36:03:: "cause to happen, occur or exist" – Could also be argued, but typically for causing an event like "produce an effect". The example "This procedure produces a curious effect" is abstract. Nucleotides are concrete substances, so "yield" is better.
- Index 2: "create or manufacture a man-made product" – Clearly not, since it's biological, not man-made.

Thus, I choose index 1.

But let's double-check: In biology, "produce" often means to synthesize. The WordNet sense mapping: The sense "bring forth or yield" includes examples like "The tree would not produce fruit." That is a natural yielding. The body producing nucleotides is analogous. The other sense "cause to happen" is more about being the reason for something, rather than being the direct agent that creates it. The enzymes directly catalyze the reactions that yield nucleotides. So I think index 1 is correct.

Therefore, the answer should be {"sense_index": 1}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: building_block
Target surface form: building blocks
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the <t>building blocks</t> of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=building_block%1:17:00:: | definition=a single undivided natural thing occurring in the composition of something else | synonyms=unit | examples=units of nucleic acids
2. sense_key=building_block%1:06:00:: | definition=a block of material used in construction work

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are asked to perform Word Sense Disambiguation for "building blocks" in the context: "pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)." The target lemma is "building_block" and the surface form is "building blocks". The candidate senses are:

1. sense_key=building_block%1:17:00:: | definition=a single undivided natural thing occurring in the composition of something else | synonyms=unit | examples=units of nucleic acids
2. sense_key=building_block%1:06:00:: | definition=a block of material used in construction work

Clearly, in the context, "building blocks" refers to nucleotides as the basic units that make up DNA and RNA. The first sense fits perfectly: "a single undivided natural thing occurring in the composition of something else" with examples "units of nucleic acids". The second sense refers to construction blocks, which is not relevant. So the answer is sense_index 1.

Return JSON: {"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: genetic
Target surface form: genetic
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the <t>genetic</t> material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=genetic%5:00:00:inheritable:00 | definition=occurring among members of a family usually by heredity | synonyms=familial, hereditary, inherited, transmitted, transmissible | examples=an inherited disease; familial traits
2. sense_key=genetic%3:01:02:: | definition=of or relating to or produced by or being a gene | synonyms=genic, genetical | examples=genic combinations; genetic code
3. sense_key=genetic%3:01:01:: | definition=pertaining to or referring to origin | examples=genetic history reconstructs the origins of a literary work
4. sense_key=genetic%3:01:00:: | definition=of or relating to the science of genetics | synonyms=genetical | examples=genetic research

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are given the target word "genetic" in context: "...the building blocks of DNA and RNA, the genetic material of cells". We need to choose the best sense from four options.

Let's examine each sense:

1. sense_key=genetic%5:00:00:inheritable:00 | definition=occurring among members of a family usually by heredity | synonyms=familial, hereditary, inherited, transmitted, transmissible | examples=an inherited disease; familial traits
   - This sense refers to inheritance within families. Here the context is about DNA/RNA as the genetic material of cells, not about familial inheritance of traits. Not applicable.

2. sense_key=genetic%3:01:02:: | definition=of or relating to or produced by or being a gene | synonyms=genic, genetical | examples=genic combinations; genetic code
   - This sense directly pertains to genes. "the genetic material of cells" refers to DNA/RNA, which is the material containing genes. This seems very fitting.

3. sense_key=genetic%3:01:01:: | definition=pertaining to or referring to origin | examples=genetic history reconstructs the origins of a literary work
   - This is about origin, like in "genetic fallacy" or "genetic history". Not relevant to DNA/RNA.

4. sense_key=genetic%3:01:00:: | definition=of or relating to the science of genetics | synonyms=genetical | examples=genetic research
   - This is about the field of genetics as a science. The phrase "genetic material" is a term from genetics, but the sense is more specifically about the material itself being related to genes, not the science. Sense 2 seems more precise: "of or relating to or produced by or being a gene". "Genetic material" means the material that genes are made of, so it is "produced by or being a gene"? Actually, genes are segments of DNA, so DNA is the genetic material. It relates to genes. So sense 2 fits best.

Thus, the best indexed sense is 2.

Return JSON: {"sense_index": 2}

provider: AtlasCloud


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: material
Target surface form: material
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic <t>material</t> of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=material%1:27:00:: | definition=the tangible substance that goes into the makeup of a physical object | synonyms=stuff | examples=coal is a hard black material; wheat is the stuff they use to make bread
2. sense_key=material%1:10:00:: | definition=information (data or ideas or observations) that can be used or reworked into a finished form | examples=the archives provided rich material for a definitive biography
3. sense_key=material%1:06:00:: | definition=artifact made by weaving or felting or knitting or crocheting natural or synthetic fibers | synonyms=fabric, cloth, textile | examples=the fabric in the curtains was light and semitransparent; woven cloth originated in Mesopotamia around 5000 BC
4. sense_key=material%1:06:01:: | definition=things needed for doing or making something | examples=writing materials; useful teaching materials
5. sense_key=material%1:18:00:: | definition=a person judged suitable for admission or employment | examples=he was university material; she was vice-presidential material

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are tasked with word sense disambiguation for the target word "material" in the given context. The context is: "the genetic material of cells". We need to choose the best indexed sense from the provided options.

Let's analyze the context. The phrase "genetic material" refers to the substance that makes up the genes, i.e., DNA and RNA. It is the physical substance of which genetic information is composed. This is a tangible substance, a physical object.

Now, look at the candidate senses:

1. sense_key=material%1:27:00:: | definition=the tangible substance that goes into the makeup of a physical object | synonyms=stuff | examples=coal is a hard black material; wheat is the stuff they use to make bread
   - This sense is about physical substances. "Genetic material" fits perfectly: it's the tangible substance (DNA, RNA) that makes up the genetic makeup of cells.

2. sense_key=material%1:10:00:: | definition=information (data or ideas or observations) that can be used or reworked into a finished form | examples=the archives provided rich material for a definitive biography
   - This is about information, not physical substance. While genetic material contains information, the context is clearly referring to the physical building blocks, not information per se. The sentence says "the building blocks of DNA and RNA, the genetic material of cells" — it's equating genetic material with the physical nucleotides, the tangible substance.

3. sense_key=material%1:06:00:: | definition=artifact made by weaving or felting or knitting or crocheting natural or synthetic fibers | synonyms=fabric, cloth, textile
   - This is about woven fabric, not relevant at all.

4. sense_key=material%1:06:01:: | definition=things needed for doing or making something | examples=writing materials; useful teaching materials
   - This is about supplies or tools, not the substance itself. Genetic material is not a "supply" in that sense; it's the substance.

5. sense_key=material%1:18:00:: | definition=a person judged suitable for admission or employment | examples=he was university material; she was vice-presidential material
   - This is about a person's suitability, not relevant.

Thus, sense 1 is the best match. It specifically refers to the tangible substance that makes up a physical object. The example "coal is a hard black material" shows that it's about physical stuff. Genetic material is indeed the physical substance of heredity.

So, answer: {"sense_index": 1}

provider: NextBit


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cells
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of <t>cells</t>). How has Alimta been studied?

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We are given a target lemma "cell" with surface form "cells" in a specific context. The context is a medical text discussing how Alimta (pemetrexed) works. It says: "pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)." So, the target word "cells" here refers to biological cells, specifically the cells that contain genetic material (DNA and RNA). That clearly points to the biological sense. Among the candidate senses, sense_index 2 is: "definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals". This matches perfectly. The context also mentions that Alimta kills dividing cells, like cancer cells, further reinforcing the biological sense. No other sense fits. Thus, the correct sense index is 2. Return {"sense_index": 2}.

provider: StreamLake


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: study
Target surface form: studied
Context:
Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been <t>studied</t>? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before.

Candidate senses:
1. sense_key=study%2:31:02:: | definition=consider in detail and subject to an analysis in order to discover essential features or meaning | synonyms=analyze, analyse, examine, canvass, canvas | examples=analyze a sonnet by Shakespeare; analyze the evidence in a criminal trial
2. sense_key=study%2:31:03:: | definition=be a student; follow a course of study; be enrolled at an institute of learning
3. sense_key=study%2:39:00:: | definition=give careful consideration to | synonyms=consider | examples=consider the possibility of moving
4. sense_key=study%2:31:00:: | definition=be a student of a certain subject | synonyms=learn, read, take | examples=She is reading for the bar exam
5. sense_key=study%2:31:01:: | definition=learn by reading books | synonyms=hit the books | examples=He is studying geology in his room; I have an exam next week; I must hit the books now
6. sense_key=study%2:31:04:: | definition=think intently and at length, as for spiritual purposes | synonyms=meditate, contemplate | examples=He is meditating in his study

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are asked to disambiguate "studied" in the sentence: "How has Alimta been studied?" from a medical context. The context discusses clinical studies on the drug Alimta. Let's evaluate each sense:

1. study%2:31:02:: "consider in detail and subject to an analysis in order to discover essential features or meaning" (analyze, examine). Example: "analyze a sonnet by Shakespeare; analyze the evidence in a criminal trial". This fits a clinical trial context: analyzing the drug's effects.

2. study%2:31:03:: "be a student; follow a course of study; be enrolled at an institute of learning". Not applicable here.

3. study%2:39:00:: "give careful consideration to" (consider). Example: "consider the possibility of moving". Too vague; clinical trials involve active investigation, not just consideration.

4. study%2:31:00:: "be a student of a certain subject" (learn, read, take). Example: "She is reading for the bar exam". Implies personal study, not clinical research.

5. study%2:31:01:: "learn by reading books" (hit the books). Example: "He is studying geology in his room". Not appropriate for drug research.

6. study%2:31:04:: "think intently and at length, as for spiritual purposes" (meditate, contemplate). Not applicable.

The context clearly refers to how the drug was investigated in clinical studies. Sense 1 (analyze, examine) is the most appropriate, as it involves detailed analysis in a research context. Synonyms like "examine" and "canvass" can apply to scientific study. Sense 3 (consider) might be a candidate, but it lacks the active investigation nuance. In medical literature, "studied" in "How has Alimta been studied?" means the drug was subjected to clinical trials and analysis. So, sense 1 is best.

Thus, answer is sense_index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: treatment
Target surface form: treatment
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the <t>treatment</t> of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=treatment%1:04:00:: | definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) | synonyms=intervention
2. sense_key=treatment%1:04:01:: | definition=the management of someone or something | synonyms=handling | examples=the handling of prisoners; the treatment of water sewage
3. sense_key=treatment%1:07:00:: | definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture
4. sense_key=treatment%1:10:00:: | definition=an extended communication (often interactive) dealing with some particular topic | synonyms=discussion, discourse | examples=the book contains an excellent discussion of modal logic; his treatment of the race question is badly biased

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are asked to perform fine-grained word sense disambiguation for the target word "treatment" in the given context. We have four candidate senses with their WordNet definitions, synonyms, and examples. The context is about how Alimta was studied for the treatment of malignant pleural mesothelioma. Specifically, the sentence is: "For the <t>treatment</t> of malignant pleural mesothelioma, Alimta has been studied in one main study..." The word "treatment" here refers to the medical intervention for a disease. Let's examine the candidate senses:

1. sense_key=treatment%1:04:00:: | definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) | synonyms=intervention
   - This seems to match the context perfectly: it's about medical treatment of a disease.

2. sense_key=treatment%1:04:01:: | definition=the management of someone or something | synonyms=handling | examples=the handling of prisoners; the treatment of water sewage
   - This sense is about managing things or people, not specifically medical. The context is about a medical therapy, so this doesn't fit as well.

3. sense_key=treatment%1:07:00:: | definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture
   - This is about artistic treatment, clearly irrelevant.

4. sense_key=treatment%1:10:00:: | definition=an extended communication (often interactive) dealing with some particular topic | synonyms=discussion, discourse | examples=the book contains an excellent discussion of modal logic; his treatment of the race question is badly biased
   - This is about a discussion or discourse, not medical treatment.

Clearly, sense 1 is the correct match: "care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)" with synonym "intervention". The context is exactly about a medical treatment for cancer.

Now, we need to return only a JSON object like {"sense_index": 1}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: study
Target surface form: studied
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been <t>studied</t> in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=study%2:31:02:: | definition=consider in detail and subject to an analysis in order to discover essential features or meaning | synonyms=analyze, analyse, examine, canvass, canvas | examples=analyze a sonnet by Shakespeare; analyze the evidence in a criminal trial
2. sense_key=study%2:31:03:: | definition=be a student; follow a course of study; be enrolled at an institute of learning
3. sense_key=study%2:39:00:: | definition=give careful consideration to | synonyms=consider | examples=consider the possibility of moving
4. sense_key=study%2:31:00:: | definition=be a student of a certain subject | synonyms=learn, read, take | examples=She is reading for the bar exam
5. sense_key=study%2:31:01:: | definition=learn by reading books | synonyms=hit the books | examples=He is studying geology in his room; I have an exam next week; I must hit the books now
6. sense_key=study%2:31:04:: | definition=think intently and at length, as for spiritual purposes | synonyms=meditate, contemplate | examples=He is meditating in his study

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are given a target lemma "study" and the surface form "studied". The context is from a medical/pharmaceutical text about Alimta, a medication. The sentence is: "For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before." The target word is "studied" in the phrase "has been studied". So the sense here is about evaluating or analyzing the drug in a clinical trial.

Let's look at the candidate senses:
1. sense_key=study%2:31:02:: | definition=consider in detail and subject to an analysis in order to discover essential features or meaning | synonyms=analyze, analyse, examine, canvass, canvas | examples=analyze a sonnet by Shakespeare; analyze the evidence in a criminal trial
2. sense_key=study%2:31:03:: | definition=be a student; follow a course of study; be enrolled at an institute of learning
3. sense_key=study%2:39:00:: | definition=give careful consideration to | synonyms=consider | examples=consider the possibility of moving
4. sense_key=study%2:31:00:: | definition=be a student of a certain subject | synonyms=learn, read, take | examples=She is reading for the bar exam
5. sense_key=study%2:31:01:: | definition=learn by reading books | synonyms=hit the books | examples=He is studying geology in his room; I have an exam next week; I must hit the books now
6. sense_key=study%2:31:04:: | definition=think intently and at length, as for spiritual purposes | synonyms=meditate, contemplate | examples=He is meditating in his study

The context is clearly about a clinical study where the drug was evaluated. "Alimta has been studied" means it was analyzed/examined in a research setting. Sense 1 fits perfectly: "consider in detail and subject to an analysis in order to discover essential features or meaning" with synonyms analyze, examine. The example "analyze the evidence in a criminal trial" is analogous to analyzing a drug in a trial.

Sense 3 ("give careful consideration to") might seem plausible, but it's more about contemplating possibilities, not systematic analysis. Sense 1 is more precise for scientific/medical analysis.

Sense 2, 4, 5 are about being a student, which is irrelevant. Sense 6 is about meditation.

Therefore, the best indexed sense is 1.

Output: {"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: main
Target surface form: main
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one <t>main</t> study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=main%5:00:00:important:00 | definition=most important element | synonyms=chief, primary, principal, master | examples=the chief aim of living; the main doors were of solid glass
2. sense_key=main%3:00:02:: | definition=(of a clause) capable of standing syntactically alone as a complete sentence | synonyms=independent | examples=the main (or independent) clause in a complex sentence has at least a subject and a verb
3. sense_key=main%5:00:00:intense:00 | definition=of force; of the greatest possible intensity | examples=by main strength

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are given the target word "main" in the context of a study description: "Alimta has been studied in one main study in 456 patients...". We need to choose the best WordNet sense among three candidates.

Candidate senses:
1. important: most important element. Synonyms: chief, primary, principal, master. Examples: "the chief aim of living; the main doors were of solid glass"
2. (of a clause) independent: capable of standing alone as a complete sentence. Example: "the main (or independent) clause..."
3. intense: of force; of the greatest possible intensity. Example: "by main strength"

The context: "one main study" clearly means the principal or most important study. Sense 1 fits perfectly: "most important element". Sense 2 is about grammar, not relevant. Sense 3 is about physical force, not relevant.

Thus, the answer is sense index 1.

Return JSON: {"sense_index": 1}