[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: genetic
Target surface form: genetic
Context:
Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging <t>genetic</t> tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings.

Candidate senses:
1. sense_key=genetic%5:00:00:inheritable:00 | definition=occurring among members of a family usually by heredity | synonyms=familial, hereditary, inherited, transmitted, transmissible | examples=an inherited disease; familial traits
2. sense_key=genetic%3:01:02:: | definition=of or relating to or produced by or being a gene | synonyms=genic, genetical | examples=genic combinations; genetic code
3. sense_key=genetic%3:01:01:: | definition=pertaining to or referring to origin | examples=genetic history reconstructs the origins of a literary work
4. sense_key=genetic%3:01:00:: | definition=of or relating to the science of genetics | synonyms=genetical | examples=genetic research

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are asked to choose the best indexed sense for "genetic" in the given context. The context discusses genetic tests that can spot individuals susceptible to cancer. The tests are related to genes and heredity. Let's evaluate each sense:

Sense 1: "occurring among members of a family usually by heredity" - synonyms include familial, hereditary. The context mentions inheriting copies of genes, and genetic tests for susceptibility. This sense fits well because the genetic tests are for inherited predispositions.

Sense 2: "of or relating to or produced by or being a gene" - synonyms: genic, genetical. Examples: "genic combinations; genetic code". This is also relevant because genetic tests relate to genes. However, sense 1 is more specific to heredity and family, which is directly applicable to the context of inherited copies and cancer susceptibility.

Sense 3: "pertaining to or referring to origin" - example: "genetic history reconstructs the origins of a literary work". This doesn't fit well; the context is about biology and medicine, not origin in a general sense.

Sense 4: "of or relating to the science of genetics" - example: "genetic research". This is plausible but more general. The context is about practical genetic tests for cancer susceptibility, which is applied genetics, but sense 1 seems more precise because it emphasizes the hereditary aspect.

The phrase "genetic tests" in the context is about detecting inherited defective copies, so sense 1 is most appropriate. The synonyms "familial, hereditary" match the idea of inherited cancer susceptibility.

Thus, best sense index is 1.

provider: DeepInfra


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: able
Target surface form: able
Context:
Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be <t>able</t> to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings.

Candidate senses:
1. sense_key=able%3:00:00:: | definition=(usually followed by `to') having the necessary means or skill or know-how or authority to do something | examples=able to swim; she was able to program her computer
2. sense_key=able%5:00:00:competent:00 | definition=have the skills and qualifications to do things well | synonyms=capable | examples=able teachers; a capable administrator
3. sense_key=able%5:00:00:capable:00 | definition=having inherent physical or mental ability or capacity | examples=able to learn; human beings are able to walk on two feet
4. sense_key=able%5:00:00:fit:01 | definition=having a strong healthy body | synonyms=able-bodied | examples=an able seaman; every able-bodied young man served in the army

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

finish_reason: stop

role: assistant

reasoning_content: We are given a context where "able" is used: "Emerging genetic tests will be able to spot such cancer-susceptible individuals..." The target form is "able" and it appears in the phrase "will be able to spot". This is a common construction meaning "have the capability to". The sense is about having the necessary means or skill to do something. Sense 1: "(usually followed by 'to') having the necessary means or skill or know-how or authority to do something" with example "able to swim". That fits perfectly. Sense 2 is about being competent in general (able teachers). Sense 3 is about inherent ability (able to learn). Sense 4 is about physical health (able-bodied). The context is about genetic tests having the capability to spot individuals. So sense 1 is the best. Thus answer: {"sense_index": 1}.

format: unknown

native_finish_reason: stop

provider: AtlasCloud

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: individual
Target surface form: individuals
Context:
Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible <t>individuals</t>, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings.

Candidate senses:
1. sense_key=individual%1:03:00:: | definition=a human being | synonyms=person, someone, somebody, mortal, soul | examples=there was too much for one person to do
2. sense_key=individual%1:18:00:: | definition=a single organism

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need to choose between sense 1 (a human being) and sense 2 (a single organism). The context: "Emerging genetic tests will be able to spot such cancer-susceptible <t>individuals</t>, ushering in what some scientists believe is a new age of predictive cancer diagnosis." The target is "individuals" referring to people who are cancer-susceptible. Clearly these are human beings. Sense 2 is "a single organism" which could include non-human organisms, but the context is about human genetic testing. Sense 1 is appropriate. So answer {"sense_index": 1}.

provider: Baidu


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: believe
Target surface form: believe
Context:
Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists <t>believe</t> is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings.

Candidate senses:
1. sense_key=believe%2:31:00:: | definition=accept as true; take to be true | examples=I believed his report; We didn't believe his stories from the War
2. sense_key=believe%2:31:04:: | definition=judge or regard; look upon; judge | synonyms=think, consider, conceive | examples=I think he is very smart; I believe her to be very smart
3. sense_key=believe%2:31:03:: | definition=be confident about something | synonyms=trust | examples=I believe that he will come back from the war
4. sense_key=believe%2:31:01:: | definition=follow a credo; have a faith; be a believer | examples=When you hear his sermons, you will be able to believe, too
5. sense_key=believe%2:31:02:: | definition=credit with veracity | examples=You cannot believe this man; Should we believe a publication like the National Enquirer?

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We need to choose the best sense for "believe" in the context: "Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists <t>believe</t> is a new age of predictive cancer diagnosis."

The context: scientists have an opinion or judgment that it is a new age. They are not necessarily accepting a fact as true (sense 1) but rather judging or regarding it as such. Sense 2: "judge or regard; look upon; judge" with synonyms think, consider. That fits. Sense 3 is "be confident about something" which is similar but more about confidence. Sense 4 is about religious faith. Sense 5 is about crediting with veracity. The best is sense 2.

Thus answer: {"sense_index": 2}

provider: Morph


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: new
Target surface form: new
Context:
Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a <t>new</t> age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings.

Candidate senses:
1. sense_key=new%3:00:00:: | definition=not of long duration; having just (or relatively recently) come into being or been made or acquired or discovered | examples=a new law; new cars
2. sense_key=new%5:00:00:original:00 | definition=original and of a kind not seen before | synonyms=fresh, novel | examples=the computer produced a completely novel proof of a well-known theorem
3. sense_key=new%5:00:00:inexperienced:00 | definition=lacking training or experience | synonyms=raw | examples=the new men were eager to fight; raw recruits
4. sense_key=new%5:00:00:unprecedented:00 | definition=having no previous example or precedent or parallel | synonyms=unexampled | examples=a time of unexampled prosperity
5. sense_key=new%5:00:00:other:00 | definition=other than the former one(s); different | examples=they now have a new leaders; my new car is four years old but has only 15,000 miles on it
6. sense_key=new%3:00:09:: | definition=unaffected by use or exposure | examples=it looks like new
7. sense_key=new%5:00:02:original:00 | definition=(of a new kind or fashion) gratuitously new | synonyms=newfangled | examples=newfangled ideas; she buys all these new-fangled machines and never uses them
8. sense_key=new%5:00:02:late:01 | definition=in use after medieval times | examples=New Eqyptian was the language of the 18th to 21st dynasties
9. sense_key=new%5:00:01:late:01 | definition=used of a living language; being the current stage in its development | synonyms=Modern | examples=Modern English; New Hebrew is Israeli Hebrew
10. sense_key=new%5:00:00:early:02 | definition=(of crops) harvested at an early stage of development; before complete maturity | synonyms=young | examples=new potatoes; young corn
11. sense_key=new%5:00:00:unaccustomed:00 | definition=unfamiliar | examples=new experiences; experiences new to him

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are given the target lemma "new" in the context: "Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a <t>new</t> age of predictive cancer diagnosis." The context is about a new era of predictive cancer diagnosis. The sense should be about something that has just come into being or is recent. Sense 1: "not of long duration; having just (or relatively recently) come into being or been made or acquired or discovered" fits well. Sense 2 is about "original and of a kind not seen before" which also fits, but sense 1 is more directly about recency. Sense 4 is "having no previous example" which also fits, but sense 1 is more general. Sense 5 is "other than the former one(s); different" which could also apply. However, the phrase "new age" typically means a recent era, so sense 1 seems best. Also, the example "a new law" is analogous. So I'll choose sense 1.

Thus {"sense_index": 1}

provider: Alibaba


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: age
Target surface form: age
Context:
Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new <t>age</t> of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings.

Candidate senses:
1. sense_key=age%1:07:00:: | definition=how long something has existed | examples=it was replaced because of its age
2. sense_key=age%1:28:02:: | definition=an era of history having some distinctive feature | synonyms=historic period | examples=we live in a litigious age
3. sense_key=age%1:28:00:: | definition=a time of life (usually defined in years) at which some particular qualification or power arises | synonyms=eld | examples=she was now of school age; tall for his eld
4. sense_key=age%1:28:03:: | definition=a prolonged period of time | synonyms=long time, years | examples=we've known each other for ages; I haven't been there for years and years
5. sense_key=age%1:28:01:: | definition=a late time of life | synonyms=old age, years, eld, geezerhood | examples=old age is not for sissies; he's showing his years

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We are given a lemma "age" in the context: "Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new <t>age</t> of predictive cancer diagnosis." The target word is "age" used as a noun. The context talks about a new era or period of predictive cancer diagnosis. This matches sense 2: "an era of history having some distinctive feature" with synonyms "historic period" and example "we live in a litigious age". The other senses refer to how long something has existed (sense 1), a time of life (sense 3), a prolonged period of time (sense 4), and old age (sense 5). Sense 2 is clearly the best fit. Therefore, the answer is {"sense_index": 2}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
Oncogenes must be present for a cell to become malignant, but researchers have found them in normal as well as in cancerous cells, suggesting that oncogenes don't cause cancer by themselves. In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive <t>cancer</t> diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We are given a target lemma "cancer" in a context about medical cancer, genetics, oncogenes, tumor-suppressor genes, etc. The candidate senses include a medical sense (sense 1), astrological senses (2, 3, 4), and a biological genus (5). Clearly the context is about disease, not astrology or crustaceans. So the correct sense is sense 1. The answer should be {"sense_index": 1}.

provider: Novita


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: first
Target surface form: first
Context:
In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the <t>first</t> beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births.

Candidate senses:
1. sense_key=first%3:00:00:: | definition=preceding all others in time or space or degree | examples=the first house on the right; the first day of spring
2. sense_key=first%5:00:00:ordinal:00 | definition=indicating the beginning unit in a series | synonyms=1st
3. sense_key=first%5:00:02:opening:00 | definition=serving to set in motion | synonyms=inaugural, initiative, initiatory, maiden | examples=the magazine's inaugural issue; the initiative phase in the negotiations
4. sense_key=first%5:00:01:opening:00 | definition=serving to begin | synonyms=beginning | examples=the beginning canto of the poem; the first verse
5. sense_key=first%5:00:00:best:00 | definition=ranking above all others | synonyms=foremost, world-class | examples=was first in her class; the foremost figure among marine artists
6. sense_key=first%3:00:03:: | definition=highest in pitch or chief among parts or voices or instruments or orchestra sections | examples=first soprano; the first violin section

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need to determine the correct sense for "first" in the context: "Bill and Bonnie Quinlan are among the first beneficiaries of the new findings." The word "first" here means they are some of the earliest beneficiaries, preceding others in time. Sense 1: "preceding all others in time or space or degree" fits well. Sense 2 is ordinal (1st) but that's more about position in a series. Sense 3 is "serving to set in motion" (inaugural), but here it's about being among the early recipients, not initiating anything. Sense 4 is "serving to begin" but again not exactly. Sense 5 is "ranking above all others" (best), but it's not about being the best; it's about being early. Sense 6 is about pitch. So sense 1 is the best match. The examples include "the first day of spring" which is about time precedence. So sense_index is 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: beneficiary
Target surface form: beneficiaries
Context:
In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first <t>beneficiaries</t> of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births.

Candidate senses:
1. sense_key=beneficiary%1:18:00:: | definition=the recipient of funds or other benefits | synonyms=donee
2. sense_key=beneficiary%1:10:00:: | definition=the semantic role of the intended recipient who benefits from the happening denoted by the verb in the clause | synonyms=benefactive role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We are given a target lemma 'beneficiary' used as plural 'beneficiaries'. The context is about genetic testing and cancer predisposition. The sentence: "Bill and Bonnie Quinlan are among the first beneficiaries of the new findings." They are receiving benefits from the new findings (i.e., the knowledge from research). This aligns with sense 1: "the recipient of funds or other benefits". Sense 2 is a linguistic role (semantic role in a clause). The context clearly refers to people who benefit from scientific discoveries. So sense 1 is correct.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: new
Target surface form: new
Context:
In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the <t>new</t> findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births.

Candidate senses:
1. sense_key=new%3:00:00:: | definition=not of long duration; having just (or relatively recently) come into being or been made or acquired or discovered | examples=a new law; new cars
2. sense_key=new%5:00:00:original:00 | definition=original and of a kind not seen before | synonyms=fresh, novel | examples=the computer produced a completely novel proof of a well-known theorem
3. sense_key=new%5:00:00:inexperienced:00 | definition=lacking training or experience | synonyms=raw | examples=the new men were eager to fight; raw recruits
4. sense_key=new%5:00:00:unprecedented:00 | definition=having no previous example or precedent or parallel | synonyms=unexampled | examples=a time of unexampled prosperity
5. sense_key=new%5:00:00:other:00 | definition=other than the former one(s); different | examples=they now have a new leaders; my new car is four years old but has only 15,000 miles on it
6. sense_key=new%3:00:09:: | definition=unaffected by use or exposure | examples=it looks like new
7. sense_key=new%5:00:02:original:00 | definition=(of a new kind or fashion) gratuitously new | synonyms=newfangled | examples=newfangled ideas; she buys all these new-fangled machines and never uses them
8. sense_key=new%5:00:02:late:01 | definition=in use after medieval times | examples=New Eqyptian was the language of the 18th to 21st dynasties
9. sense_key=new%5:00:01:late:01 | definition=used of a living language; being the current stage in its development | synonyms=Modern | examples=Modern English; New Hebrew is Israeli Hebrew
10. sense_key=new%5:00:00:early:02 | definition=(of crops) harvested at an early stage of development; before complete maturity | synonyms=young | examples=new potatoes; young corn
11. sense_key=new%5:00:00:unaccustomed:00 | definition=unfamiliar | examples=new experiences; experiences new to him

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We are given a sentence: "Bill and Bonnie Quinlan are among the first beneficiaries of the <t>new</t> findings." The context discusses emerging genetic tests and the idea of a new age of predictive cancer diagnosis. The word "new" here modifies "findings". The findings are recent discoveries about tumor-suppressor genes and cancer. The sense should be about something that has recently come into being or been discovered. Sense 1: "not of long duration; having just (or relatively recently) come into being or been made or acquired or discovered" fits well. The example "a new law" is parallel. The other senses: sense 2 is "original and of a kind not seen before" but that might be too strong; sense 5 "other than the former one(s)" might also apply but less likely; sense 6 "unaffected by use" doesn't fit; sense 7 "newfangled" has negative connotation; sense 10 is about crops; etc. The best is sense 1. So answer: {"sense_index": 1}

provider: Wafer


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: finding
Target surface form: findings
Context:
In recent months, researchers have come to believe the two types of cancer genes work in concert: An oncogene may turn proliferating cells malignant only after the tumor-suppressor gene has been damaged. Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new <t>findings</t>. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births.

Candidate senses:
1. sense_key=finding%1:04:00:: | definition=the act of determining the properties of something, usually by research or calculation | synonyms=determination | examples=the determination of molecular structures
2. sense_key=finding%1:04:01:: | definition=the decision of a court on issues of fact or law
3. sense_key=finding%1:17:00:: | definition=something that is found | examples=the findings in the gastrointestinal tract indicate that he died several hours after dinner; an area rich in archaeological findings

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We are given the target lemma "finding" with surface form "findings" in the context: "Bill and Bonnie Quinlan are among the first beneficiaries of the new findings." The context discusses genetic research and discoveries about cancer genes. The word "findings" here refers to the results of research, the discoveries made by scientists. Among the candidate senses: sense 1 is the act of determining properties (like determination of molecular structures), sense 2 is a court decision, sense 3 is something that is found (like archaeological findings). In this context, "new findings" clearly refers to new discoveries or results from research. That matches sense 3: "something that is found." The example given for sense 3 includes "archaeological findings" which is analogous to scientific findings. Sense 1 is about the process of determination, not the result. So the best index is 3.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: couple
Target surface form: couple
Context:
Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., <t>couple</t> knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby.

Candidate senses:
1. sense_key=couple%1:14:00:: | definition=a pair who associate with one another | synonyms=twosome, duo, duet | examples=the engaged couple; an inseparable twosome
2. sense_key=couple%1:14:01:: | definition=a pair of people who live together | synonyms=mates, match | examples=a married couple from Chicago
3. sense_key=couple%1:23:01:: | definition=a small indefinite number | examples=he's coming for a couple of days
4. sense_key=couple%1:23:00:: | definition=two items of the same kind | synonyms=pair, twosome, twain, brace, span, yoke
5. sense_key=couple%1:17:00:: | definition=(physics) something joined by two equal and opposite forces that act along parallel lines

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
We are given a sentence: "The Dedham, Mass., <t>couple</t> knew even before Bonnie became pregnant...". The context is about Bill and Bonnie Quinlan, who are a married couple. They are referred to as "the couple" meaning a pair of people who live together, specifically a married couple. The candidate senses:
1. sense_key=couple%1:14:00:: definition: a pair who associate with one another (synonyms: twosome, duo, duet; examples: the engaged couple; an inseparable twosome)
2. sense_key=couple%1:14:01:: definition: a pair of people who live together (synonyms: mates, match; examples: a married couple from Chicago)
3. sense_key=couple%1:23:01:: definition: a small indefinite number (examples: he's coming for a couple of days)
4. sense_key=couple%1:23:00:: definition: two items of the same kind (synonyms: pair, twosome, twain, brace, span, yoke)
5. sense_key=couple%1:17:00:: definition: (physics) something joined by two equal and opposite forces that act along parallel lines

The context clearly indicates a married couple, so sense 2 (a pair of people who live together) is appropriate. The example given is "a married couple from Chicago" which matches. Sense 1 is also about a pair who associate, but it includes "engaged couple" which is not married but still a pair. However, the context specifies that they are married (Bill and Bonnie Quinlan). Also, the phrase "the Dedham, Mass., couple" implies they live together? Actually, they are a married couple. So sense 2 is more specific. But note: the definition says "a pair of people who live together" and the example is "a married couple from Chicago". So sense 2 seems best.

We must return only the sense index number. The answer should be a JSON object with "sense_index". The indices are based on the order:
1. sense_key=couple%1:14:00:: -> index 1
2. sense_key=couple%1:14:01:: -> index 2
3. sense_key=couple%1:23:01:: -> index 3
4. sense_key=couple%1:23:00:: -> index 4
5. sense_key=couple%1:17:00:: -> index 5

So the correct choice is sense index 2. But wait, the instructions say "Do not answer with a WordNet sense key." So we should output the index number. Also, the user said "Return only a JSON object exactly like {"sense_index": 3}." They gave an example with 3, but we need to choose the correct one. So we output {"sense_index": 2}.{"sense_index": 2}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: couple
Target surface form: couple
Context:
Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., <t>couple</t> knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby.

Candidate senses:
1. sense_key=couple%1:14:00:: | definition=a pair who associate with one another | synonyms=twosome, duo, duet | examples=the engaged couple; an inseparable twosome
2. sense_key=couple%1:14:01:: | definition=a pair of people who live together | synonyms=mates, match | examples=a married couple from Chicago
3. sense_key=couple%1:23:01:: | definition=a small indefinite number | examples=he's coming for a couple of days
4. sense_key=couple%1:23:00:: | definition=two items of the same kind | synonyms=pair, twosome, twain, brace, span, yoke
5. sense_key=couple%1:17:00:: | definition=(physics) something joined by two equal and opposite forces that act along parallel lines

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

[Assistant]
We are given a sentence: "The Dedham, Mass., <t>couple</t> knew even before Bonnie became pregnant...". The context is about Bill and Bonnie Quinlan, who are a married couple. They are referred to as "the couple" meaning a pair of people who live together, specifically a married couple. The candidate senses:
1. sense_key=couple%1:14:00:: definition: a pair who associate with one another (synonyms: twosome, duo, duet; examples: the engaged couple; an inseparable twosome)
2. sense_key=couple%1:14:01:: definition: a pair of people who live together (synonyms: mates, match; examples: a married couple from Chicago)
3. sense_key=couple%1:23:01:: definition: a small indefinite number (examples: he's coming for a couple of days)
4. sense_key=couple%1:23:00:: definition: two items of the same kind (synonyms: pair, twosome, twain, brace, span, yoke)
5. sense_key=couple%1:17:00:: definition: (physics) something joined by two equal and opposite forces that act along parallel lines

The context clearly indicates a married couple, so sense 2 (a pair of people who live together) is appropriate. The example given is "a married couple from Chicago" which matches. Sense 1 is also about a pair who associate, but it includes "engaged couple" which is not married but still a pair. However, the context specifies that they are married (Bill and Bonnie Quinlan). Also, the phrase "the Dedham, Mass., couple" implies they live together? Actually, they are a married couple. So sense 2 is more specific. But note: the definition says "a pair of people who live together" and the example is "a married couple from Chicago". So sense 2 seems best.

We must return only the sense index number. The answer should be a JSON object with "sense_index". The indices are based on the order:
1. sense_key=couple%1:14:00:: -> index 1
2. sense_key=couple%1:14:01:: -> index 2
3. sense_key=couple%1:23:01:: -> index 3
4. sense_key=couple%1:23:00:: -> index 4
5. sense_key=couple%1:17:00:: -> index 5

So the correct choice is sense index 2. But wait, the instructions say "Do not answer with a WordNet sense key." So we should output the index number. Also, the user said "Return only a JSON object exactly like {"sense_index": 3}." They gave an example with 3, but we need to choose the correct one. So we output {"sense_index": 2}.{"sense_index": 2}

[User] Your previous answer was invalid. Choose one candidate index between 1 and 5. Return only valid JSON exactly like {"sense_index": 1}.

reasoning_content: We need to output the index of the best sense. The context clearly indicates a married couple (Bill and Bonnie Quinlan). Sense 2 is "a pair of people who live together" with example "a married couple from Chicago". That fits perfectly. Sense 1 is more general (a pair who associate) but the specific married context points to sense 2. So answer is 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: know
Target surface form: knew
Context:
Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple <t>knew</t> even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby.

Candidate senses:
1. sense_key=know%2:31:01:: | definition=be cognizant or aware of a fact or a specific piece of information; possess knowledge or information about | synonyms=cognize, cognise | examples=I know that the President lied to the people; I want to know who is winning the game!
2. sense_key=know%2:31:03:: | definition=know how to do or perform something | examples=She knows how to knit; Does your husband know how to cook?
3. sense_key=know%2:31:02:: | definition=be aware of the truth of something; have a belief or faith in something; regard as true beyond any doubt | examples=I know that I left the key on the table; Galileo knew that the earth moves around the sun
4. sense_key=know%2:31:00:: | definition=be familiar or acquainted with a person or an object | examples=She doesn't know this composer; Do you know my sister?
5. sense_key=know%2:31:04:: | definition=have firsthand knowledge of states, situations, emotions, or sensations | synonyms=experience, live | examples=I know the feeling!; have you ever known hunger?
6. sense_key=know%2:31:06:: | definition=accept (someone) to be what is claimed or accept his power and authority | synonyms=acknowledge, recognize, recognise | examples=The Crown Prince was acknowledged as the true heir to the throne; We do not recognize your gods
7. sense_key=know%2:31:15:: | definition=have fixed in the mind | examples=I know Latin; This student knows her irregular verbs
8. sense_key=know%2:35:00:: | definition=have sexual intercourse with | synonyms=sleep together, roll in the hay, love, make out, make love, sleep with | examples=This student sleeps with everyone in her dorm; Adam knew Eve
9. sense_key=know%2:31:11:: | definition=know the nature or character of | examples=we all knew her as a big show-off
10. sense_key=know%2:31:12:: | definition=be able to distinguish, recognize as being different | examples=The child knows right from wrong
11. sense_key=know%2:31:14:: | definition=perceive as familiar | examples=I know this voice!

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are given: "Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple <t>knew</t> even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma..."

The target word is "knew". The context indicates that the couple had knowledge of a fact: that any child had a 50% chance of being at risk. This is about being aware of a specific piece of information. Sense 1: "be cognizant or aware of a fact or a specific piece of information; possess knowledge or information about" fits well. Sense 3: "be aware of the truth of something; have a belief or faith in something; regard as true beyond any doubt" also seems similar. But sense 1 explicitly mentions "a fact or a specific piece of information", which matches the probabilistic fact. Sense 3 emphasizes "regard as true beyond any doubt", but here it's a known probability, not necessarily beyond doubt. The example for sense 1: "I know that the President lied to the people" is similar to knowing a fact. The example for sense 3: "Galileo knew that the earth moves around the sun" is also a fact. However, sense 1 is more general for factual knowledge. Also, sense 2 is about knowing how to do something, not applicable. Sense 4 is about being familiar with a person or object, not applicable. Sense 5 is about firsthand experience, not applicable. Sense 6 is about accepting authority, not applicable. Sense 7 is about having fixed in the mind (like knowing a language), not applicable. Sense 8 is sexual, not applicable. Sense 9 is about knowing the nature or character, not applicable. Sense 10 is about distinguishing, not applicable. Sense 11 is about perceiving as familiar, not applicable.

Thus, the best is sense 1. But note: sense 1 and sense 3 are very close. The key difference: sense 1 is "be cognizant or aware of a fact or a specific piece of information", sense 3 is "be aware of the truth of something; have a belief or faith in something; regard as true beyond any doubt". The context says "knew even before... that any child... had a 50% chance". This is a fact, but it's a probabilistic fact. They are aware of this information. I think sense 1 is more appropriate because it's about possessing knowledge of a specific piece of information. Sense 3 might imply a stronger certainty, but here it's a known risk. Also, the example for sense 1 includes "I want to know who is winning the game!" which is about a specific piece of information. So I'll go with sense 1.

Thus, answer: {"sense_index": 1}

provider: Cloudflare


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: even
Target surface form: even
Context:
Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew <t>even</t> before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby.

Candidate senses:
1. sense_key=even%4:02:00:: | definition=used as an intensive especially to indicate something unexpected | examples=even an idiot knows that; declined even to consider the idea
2. sense_key=even%4:02:03:: | definition=in spite of; notwithstanding | examples=even when he is sick, he works; even with his head start she caught up with him
3. sense_key=even%4:02:01:: | definition=to a greater degree or extent; used with comparisons | synonyms=yet, still | examples=looked sick and felt even worse; an even (or still) more interesting problem
4. sense_key=even%4:02:04:: | definition=to the full extent | examples=loyal even unto death

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are given: "The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma". The target word 'even' here is used as an adverb meaning "used as an intensive especially to indicate something unexpected" (sense 1) or "in spite of; notwithstanding" (sense 2)? Let's analyze.

The context: They knew before she became pregnant. The word 'even' emphasizes that they knew at a time before pregnancy, which might be unexpected or emphatic. It is not a comparison (sense 3) or "to the full extent" (sense 4). Sense 1 says "used as an intensive especially to indicate something unexpected" - that fits: they knew even before pregnancy, which is surprising or intensive. Sense 2: "in spite of; notwithstanding" - doesn't fit because it's not contrasting something. So sense 1 is best. But careful: The examples for sense 1: "even an idiot knows that; declined even to consider the idea" - these have 'even' emphasizing the unexpectedness. In our sentence, "even before" emphasizes that they knew prior to pregnancy, which might be unexpected given the usual timing of such knowledge. So sense 1.

Thus answer: {"sense_index": 1}

provider: GMICloud


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: before
Target surface form: before
Context:
Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even <t>before</t> Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby.

Candidate senses:
1. sense_key=before%4:02:03:: | definition=earlier in time; previously | synonyms=earlier | examples=I had known her before; as I said before
2. sense_key=before%4:02:01:: | definition=at or in the front | synonyms=ahead, in front | examples=I see the lights of a town ahead; the road ahead is foggy

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are given the target lemma "before" in the context: "The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma." The target is the word "before" in that phrase. We need to choose between two senses:

Sense 1: earlier in time; previously. Example: "I had known her before; as I said before."
Sense 2: at or in the front. Synonyms: ahead, in front. Example: "I see the lights of a town ahead; the road ahead is foggy."

In the context, "before" is used in a temporal sense: "knew even before Bonnie became pregnant" meaning earlier in time than the pregnancy. So it clearly fits sense 1. Sense 2 is spatial (in front). Therefore, the best sense is sense 1.

Thus, output: {"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: become
Target surface form: became
Context:
Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie <t>became</t> pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby.

Candidate senses:
1. sense_key=become%2:30:00:: | definition=enter or assume a certain state or condition | synonyms=go, get | examples=He became annoyed when he heard the bad news; It must be getting more serious
2. sense_key=become%2:42:01:: | definition=undergo a change or development | synonyms=turn | examples=The water turned into ice; Her former friend became her worst enemy
3. sense_key=become%2:42:00:: | definition=come into existence | examples=What becomes has duration
4. sense_key=become%2:42:03:: | definition=enhance the appearance of | synonyms=suit | examples=Mourning becomes Electra; This behavior doesn't suit you!

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We need to choose the best sense for "became" in the context: "Bonnie became pregnant". The target surface form is "became". The context is about a woman becoming pregnant. Let's examine each sense:

1. sense 1: "enter or assume a certain state or condition" with synonyms "go, get". Examples: "He became annoyed", "It must be getting more serious". This fits "became pregnant" as entering a state of pregnancy.

2. sense 2: "undergo a change or development" with synonym "turn". Examples: "The water turned into ice", "Her former friend became her worst enemy". This also could fit, but "became pregnant" is more about entering a state than a transformation into something else. However, pregnancy is a change.

3. sense 3: "come into existence". Example: "What becomes has duration". This seems more abstract and less fitting for "became pregnant". Pregnancy is a state, not coming into existence.

4. sense 4: "enhance the appearance of" with synonym "suit". Examples: "Mourning becomes Electra", "This behavior doesn't suit you!". Clearly not.

Thus, sense 1 is the best fit. The example "He became annoyed" is similar structure: become + adjective/past participle. "Became pregnant" is similar. Sense 2 might also be plausible, but sense 1 is more specific to entering a state. WordNet often groups "become" as "enter a state" for such uses. So I'll choose sense 1.

Return JSON with sense_index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: pregnant
Target surface form: pregnant
Context:
Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became <t>pregnant</t> in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby.

Candidate senses:
1. sense_key=pregnant%3:00:00:: | definition=carrying developing offspring within the body or being about to produce new life
2. sense_key=pregnant%5:00:00:meaningful:00 | definition=rich in significance or implication | synonyms=meaning, significant | examples=a meaning look
3. sense_key=pregnant%5:00:00:full:00 | definition=filled with or attended with | synonyms=fraught | examples=words fraught with meaning; an incident fraught with danger

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We are given a context where Bonnie became pregnant in 1987. The target word "pregnant" is used in the phrase "Bonnie became pregnant". This clearly refers to carrying a developing offspring. The first sense (sense 1) is "carrying developing offspring within the body or being about to produce new life". The other senses are figurative: meaningful or fraught. The context is literal, about having a child. So the best sense is sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: child
Target surface form: child
Context:
Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any <t>child</t> of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby.

Candidate senses:
1. sense_key=child%1:18:00:: | definition=a young person of either sex | synonyms=kid, youngster, minor, shaver, nipper, small fry | examples=she writes books for children; they're just kids
2. sense_key=child%1:18:01:: | definition=a human offspring (son or daughter) of any age | synonyms=kid | examples=they had three children; they were able to send their kids to college
3. sense_key=child%1:18:06:: | definition=an immature childish person | synonyms=baby | examples=he remained a child in practical matters as long as he lived; stop being a baby!
4. sense_key=child%1:18:07:: | definition=a member of a clan or tribe | examples=the children of Israel

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need to choose the best sense for "child" in the context. The context: "any <t>child</t> of theirs had a 50% chance of being at risk for retinoblastoma". This refers to a biological offspring, i.e., a son or daughter. The sentence discusses inheritance of a damaged gene from parents to offspring. Sense 2 is "a human offspring (son or daughter) of any age". Sense 1 is "a young person of either sex", but here the focus is on offspring, not just young person. The child could be any age, but the context is about genetic inheritance. So sense 2 fits best. Sense 3 is an immature childish person, not relevant. Sense 4 is a member of a clan or tribe, not relevant. Thus answer is sense_index 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: chance
Target surface form: chance
Context:
Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% <t>chance</t> of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby.

Candidate senses:
1. sense_key=chance%1:26:00:: | definition=a possibility due to a favorable combination of circumstances | synonyms=opportunity | examples=the holiday gave us the opportunity to visit Washington; now is your chance
2. sense_key=chance%1:19:00:: | definition=an unknown and unpredictable phenomenon that causes an event to result one way rather than another | synonyms=luck, fortune, hazard | examples=bad luck caused his downfall; we ran into each other by pure chance
3. sense_key=chance%1:04:00:: | definition=a risk involving danger | examples=you take a chance when you let her drive
4. sense_key=chance%1:07:00:: | definition=a measure of how likely it is that some event will occur; a number expressing the ratio of favorable cases to the whole number of cases possible | synonyms=probability | examples=the probability that an unbiased coin will fall with the head up is 0.5
5. sense_key=chance%1:26:01:: | definition=the possibility of future success | synonyms=prospect | examples=his prospects as a writer are excellent

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We are given a sentence: "any child of theirs had a 50% chance of being at risk for retinoblastoma". The word "chance" here refers to a probability, a measure of likelihood. The context includes "50%", which is a numerical probability. Sense 4 is "a measure of how likely it is that some event will occur; a number expressing the ratio of favorable cases to the whole number of cases possible" with synonyms like "probability". The example given for sense 4: "the probability that an unbiased coin will fall with the head up is 0.5". That matches exactly the usage: 50% chance. The other senses don't fit as well. Sense 1 is an opportunity, sense 2 is luck, sense 3 is risk, sense 5 is prospect. So sense 4 is the correct one. Return {"sense_index": 4}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: eye
Target surface form: eye
Context:
Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an <t>eye</t> cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby.

Candidate senses:
1. sense_key=eye%1:08:00:: | definition=the organ of sight | synonyms=oculus, optic
2. sense_key=eye%1:09:00:: | definition=good discernment (either visually or as if visually) | examples=she has an eye for fresh talent; he has an artist's eye
3. sense_key=eye%1:09:01:: | definition=attention to what is seen | examples=he tried to catch her eye
4. sense_key=eye%1:15:00:: | definition=an area that is approximately central within some larger region | synonyms=center, centre, middle, heart | examples=it is in the center of town; they ran forward into the heart of the struggle
5. sense_key=eye%1:06:00:: | definition=a small hole or loop (as in a needle) | examples=the thread wouldn't go through the eye

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are given the target word "eye" in the context: "an <t>eye</t> cancer that occurs about once every 20,000 births." The context also mentions "retinoblastoma" which is a type of eye cancer. So the word "eye" here refers to the organ of sight. Therefore, the best sense is sense 1: "the organ of sight".

The candidate senses:
1. eye%1:08:00:: definition=the organ of sight synonyms=oculus, optic
2. eye%1:09:00:: definition=good discernment (either visually or as if visually)
3. eye%1:09:01:: definition=attention to what is seen
4. eye%1:15:00:: definition=an area that is approximately central within some larger region
5. eye%1:06:00:: definition=a small hole or loop (as in a needle)

Clearly, the context is about a cancer of the eye, so sense 1 is correct.

Thus, the output should be {"sense_index": 1}.

provider: SiliconFlow


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye <t>cancer</t> that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We are given the target lemma "cancer" in a context about medical genetics, tumors, and retinoblastoma. The candidate senses include medical (sense 1), astrology (sense 2, 4), constellation (sense 3), and genus (sense 5). Clearly the context is medical: "eye cancer", "tumor", "genetic tests", "diagnosis". So sense 1 is correct. The question asks to output JSON with sense_index, which is the number of the sense in the list. Sense 1 is the first. So answer: {"sense_index": 1}.

provider: DigitalOcean


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: occur
Target surface form: occurs
Context:
Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that <t>occurs</t> about once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby.

Candidate senses:
1. sense_key=occur%2:30:00:: | definition=come to pass | synonyms=happen, hap, go on, pass off, pass, fall out | examples=What is happening?; The meeting took place off without an incidence
2. sense_key=occur%2:31:00:: | definition=come to one's mind; suggest itself | synonyms=come | examples=It occurred to me that we should hire another secretary; A great idea then came to her
3. sense_key=occur%2:42:03:: | definition=to be found to exist | examples=sexism occurs in many workplaces; precious stones occur in a large area in Brazil

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need to choose the best sense for "occurs" in the context: "an eye cancer that <t>occurs</t> about once every 20,000 births." The context indicates the frequency of occurrence of the cancer. Sense 3 is "to be found to exist" with example "precious stones occur in a large area" which matches the idea of existing or happening with a certain frequency. Sense 1 is "come to pass" which is more about events happening, but here it's about the existence of the cancer. Sense 2 is about coming to mind. So sense 3 is best.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: about
Target surface form: about
Context:
Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs <t>about</t> once every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby.

Candidate senses:
1. sense_key=about%4:02:00:: | definition=(of quantities) imprecise but fairly close to correct | synonyms=approximately, close to, just about, some, roughly, more or less | examples=lasted approximately an hour; in just about a minute
2. sense_key=about%4:02:06:: | definition=all around or on all sides | synonyms=around | examples=dirty clothes lying around (or about); let's look about for help
3. sense_key=about%4:02:01:: | definition=in the area or vicinity | synonyms=around | examples=a few spectators standing about; hanging around
4. sense_key=about%4:02:04:: | definition=used of movement to or among many different places or in no particular direction | synonyms=around | examples=wandering about with no place to go; people were rushing about
5. sense_key=about%4:02:02:: | definition=in or to a reversed position or direction | synonyms=around | examples=about face; suddenly she turned around
6. sense_key=about%4:02:03:: | definition=in rotation or succession | examples=turn about is fair play
7. sense_key=about%4:02:05:: | definition=(of actions or states) slightly short of or not quite accomplished; all but | synonyms=almost, most, nearly, near, nigh, virtually | examples=the job is (just) about done; the baby was almost asleep when the alarm sounded

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are given a context: "that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs <t>about</t> once every 20,000 births."

The word "about" here is used in the sense of "approximately" or "roughly". It indicates a quantity that is imprecise but close to correct. That matches candidate sense 1: "(of quantities) imprecise but fairly close to correct" with synonyms like approximately, close to, just about, some, roughly, more or less. The example "lasted approximately an hour" shows similar usage.

Other senses involve spatial or movement meanings, or "almost" (sense 7). But sense 7 is for "almost" or "nearly" as in "the job is (just) about done", which is different. Here it's about a quantity (once every 20,000 births). So sense 1 is correct.

Thus, the answer is {"sense_index": 1}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: once
Target surface form: once
Context:
Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about <t>once</t> every 20,000 births. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby.

Candidate senses:
1. sense_key=once%4:02:00:: | definition=on one occasion | synonyms=one time, in one case | examples=once I ran into her
2. sense_key=once%4:02:02:: | definition=as soon as | examples=once we are home, we can rest
3. sense_key=once%4:02:01:: | definition=at a previous time | synonyms=formerly, at one time, erstwhile, erst | examples=at one time he loved her; her erstwhile writing

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need to choose the best sense for "once" in the context: "an eye cancer that occurs about once every 20,000 births." Here, "once" means "on one occasion" or "one time" per 20,000 births. That matches sense 1: "on one occasion" (synonyms: one time, in one case). Sense 2 is "as soon as" (temporal conjunction), sense 3 is "at a previous time" (formerly). Clearly sense 1 is correct. So answer: {"sense_index": 1}.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: birth
Target surface form: births
Context:
Like all genes, tumor-suppressor genes are inherited in two copies, one from each parent. Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 <t>births</t>. Mr. Quinlan, 30 years old, knew he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby.

Candidate senses:
1. sense_key=birth%1:28:00:: | definition=the time when something begins (especially life) | examples=they divorced after the birth of the child; his election signaled the birth of a new age
2. sense_key=birth%1:11:00:: | definition=the event of being born | synonyms=nativity, nascency, nascence | examples=they celebrated the birth of their first child
3. sense_key=birth%1:22:00:: | definition=the process of giving birth | synonyms=parturition, giving birth, birthing
4. sense_key=birth%1:24:00:: | definition=the kinship relation of an offspring to the parents | synonyms=parentage
5. sense_key=birth%1:18:00:: | definition=a baby born; an offspring | examples=the overall rate of incidence of Down's syndrome is one in every 800 births

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We are given the target word "births" in the context: "Eye cancer that occurs about once every 20,000 births." The phrase is comparing the frequency of retinoblastoma relative to the number of births (i.e., live births or total births). The definition for sense 5 is "a baby born; an offspring" with example "the overall rate of incidence of Down's syndrome is one in every 800 births." This matches the usage: "once every 20,000 births" meaning per number of babies born. Sense 2 ("the event of being born") could also fit but the phrasing "every 20,000 births" is more naturally interpreted as per number of births (babies) rather than events. Sense 5 specifically describes "a baby born" and the example is parallel. Sense 1, 3, 4 are less appropriate. So the best choice is sense 5.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: know
Target surface form: knew
Context:
Either copy can make the proteins needed to control cell growth, so for cancer to arise, both copies must be impaired. A person who is born with one defective copy of a suppressor gene, or in whom one copy is damaged early in life, is especially prone to cancer because he need only lose the other copy for a cancer to develop. Emerging genetic tests will be able to spot such cancer-susceptible individuals, ushering in what some scientists believe is a new age of predictive cancer diagnosis. Bill and Bonnie Quinlan are among the first beneficiaries of the new findings. The Dedham, Mass., couple knew even before Bonnie became pregnant in 1987 that any child of theirs had a 50% chance of being at risk for retinoblastoma, an eye cancer that occurs about once every 20,000 births. Mr. Quinlan, 30 years old, <t>knew</t> he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old -- after his mother had suffered the same fate when she was a baby. Because of the isolation of the retinoblastoma tumor-suppressor gene, it became possible last January to find out what threat the Quinlan baby faced.

Candidate senses:
1. sense_key=know%2:31:01:: | definition=be cognizant or aware of a fact or a specific piece of information; possess knowledge or information about | synonyms=cognize, cognise | examples=I know that the President lied to the people; I want to know who is winning the game!
2. sense_key=know%2:31:03:: | definition=know how to do or perform something | examples=She knows how to knit; Does your husband know how to cook?
3. sense_key=know%2:31:02:: | definition=be aware of the truth of something; have a belief or faith in something; regard as true beyond any doubt | examples=I know that I left the key on the table; Galileo knew that the earth moves around the sun
4. sense_key=know%2:31:00:: | definition=be familiar or acquainted with a person or an object | examples=She doesn't know this composer; Do you know my sister?
5. sense_key=know%2:31:04:: | definition=have firsthand knowledge of states, situations, emotions, or sensations | synonyms=experience, live | examples=I know the feeling!; have you ever known hunger?
6. sense_key=know%2:31:06:: | definition=accept (someone) to be what is claimed or accept his power and authority | synonyms=acknowledge, recognize, recognise | examples=The Crown Prince was acknowledged as the true heir to the throne; We do not recognize your gods
7. sense_key=know%2:31:15:: | definition=have fixed in the mind | examples=I know Latin; This student knows her irregular verbs
8. sense_key=know%2:35:00:: | definition=have sexual intercourse with | synonyms=sleep together, roll in the hay, love, make out, make love, sleep with | examples=This student sleeps with everyone in her dorm; Adam knew Eve
9. sense_key=know%2:31:11:: | definition=know the nature or character of | examples=we all knew her as a big show-off
10. sense_key=know%2:31:12:: | definition=be able to distinguish, recognize as being different | examples=The child knows right from wrong
11. sense_key=know%2:31:14:: | definition=perceive as familiar | examples=I know this voice!

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need to choose the best sense for "knew" in the given context. The sentence: "Mr. Quinlan, 30 years old, <t>knew</t> he carried a damaged gene, having lost an eye to the rare tumor when he was only two months old..." This is about being aware of a fact (that he carried a damaged gene). The definition in sense 1: "be cognizant or aware of a fact or a specific piece of information; possess knowledge or information about" fits perfectly. Sense 3 is "be aware of the truth of something; have a belief or faith in something; regard as true beyond any doubt" which also fits, but sense 1 seems more general and matches the example "I know that the President lied to the people." Sense 3 might emphasize certainty, but here it's factual knowledge. Sense 2 is about knowing how to do something, not applicable. Sense 4 is being familiar with a person/object. Sense 5 is firsthand experience, but he knows he carries a gene based on medical knowledge not necessarily firsthand experience (he lost an eye, but the knowledge is factual). Sense 6 is acceptance. Sense 7 is having fixed in mind (like memorized), not exactly. Sense 8 is sexual, no. Sense 9 is knowing the nature, but here it's a fact. Sense 10 is distinguish, not. Sense 11 is perceive as familiar, not. Best is sense 1. So output {"sense_index": 1}.