[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: convert
Target surface form: converted
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=convert%2:30:00:: | definition=change from one system to another or to a new plan or policy | synonyms=change over | examples=We converted from 220 to 110 Volt
2. sense_key=convert%2:30:03:: | definition=change the nature, purpose, or function of something | examples=convert lead into gold; convert hotels into jails
3. sense_key=convert%2:30:01:: | definition=change religious beliefs, or adopt a religious belief | examples=She converted to Buddhism
4. sense_key=convert%2:30:02:: | definition=exchange or replace with another, usually of the same kind or category | synonyms=change, exchange, commute | examples=Could you convert my dollars into pounds?; He changed his name
5. sense_key=convert%2:30:07:: | definition=cause to adopt a new or different faith | examples=The missionaries converted the Indian population
6. sense_key=convert%2:33:02:: | definition=score an extra point or points after touchdown by kicking the ball through the uprights or advancing the ball into the end zone | examples=Smith converted and his team won
7. sense_key=convert%2:33:01:: | definition=complete successfully | examples=score a penalty shot or free throw
8. sense_key=convert%2:33:00:: | definition=score (a spare)
9. sense_key=convert%2:32:00:: | definition=make (someone) agree, understand, or realize the truth or validity of something | synonyms=win over, convince | examples=He had finally convinced several customers of the advantages of his product
10. sense_key=convert%2:30:09:: | definition=exchange a penalty for a less severe one | synonyms=commute, exchange
11. sense_key=convert%2:30:04:: | definition=change in nature, purpose, or function; undergo a chemical change | examples=The substance converts to an acid

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output: We are given the target word "converted" in the context: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes..." This is about a chemical transformation. The candidate senses include several. Sense 11: "convert%2:30:04::" has definition: "change in nature, purpose, or function; undergo a chemical change" with example "The substance converts to an acid". That matches well. Also sense 2: "change the nature, purpose, or function of something" with examples like "convert lead into gold" also fits but sense 2 is more about changing function, while sense 11 specifically mentions "undergo a chemical change". The context says "converted into an active form" which is a chemical change. So sense 11 is best. However, note that sense keys have numbers. The candidate list shows sense 11 as index 11? Actually the list: 1 through 11. The last one is sense 11: "convert%2:30:04::" with definition "change in nature, purpose, or function; undergo a chemical change". That is most appropriate. So answer should be {"sense_index": 11}. But check: there is also sense 2: "change the nature, purpose, or function of something" but that doesn't explicitly mention chemical change. The example "convert lead into gold" is alchemy, but still a chemical change? Actually it's a transformation. But sense 11 is more specific to chemical change. Since the context is about a drug being converted into active form, it's a chemical process. So sense 11 is best.{"sense_index": 11}


status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: convert
Target surface form: converted
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=convert%2:30:00:: | definition=change from one system to another or to a new plan or policy | synonyms=change over | examples=We converted from 220 to 110 Volt
2. sense_key=convert%2:30:03:: | definition=change the nature, purpose, or function of something | examples=convert lead into gold; convert hotels into jails
3. sense_key=convert%2:30:01:: | definition=change religious beliefs, or adopt a religious belief | examples=She converted to Buddhism
4. sense_key=convert%2:30:02:: | definition=exchange or replace with another, usually of the same kind or category | synonyms=change, exchange, commute | examples=Could you convert my dollars into pounds?; He changed his name
5. sense_key=convert%2:30:07:: | definition=cause to adopt a new or different faith | examples=The missionaries converted the Indian population
6. sense_key=convert%2:33:02:: | definition=score an extra point or points after touchdown by kicking the ball through the uprights or advancing the ball into the end zone | examples=Smith converted and his team won
7. sense_key=convert%2:33:01:: | definition=complete successfully | examples=score a penalty shot or free throw
8. sense_key=convert%2:33:00:: | definition=score (a spare)
9. sense_key=convert%2:32:00:: | definition=make (someone) agree, understand, or realize the truth or validity of something | synonyms=win over, convince | examples=He had finally convinced several customers of the advantages of his product
10. sense_key=convert%2:30:09:: | definition=exchange a penalty for a less severe one | synonyms=commute, exchange
11. sense_key=convert%2:30:04:: | definition=change in nature, purpose, or function; undergo a chemical change | examples=The substance converts to an acid

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

[Assistant] We are given the target word "converted" in the context: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes..." This is about a chemical transformation. The candidate senses include several. Sense 11: "convert%2:30:04::" has definition: "change in nature, purpose, or function; undergo a chemical change" with example "The substance converts to an acid". That matches well. Also sense 2: "change the nature, purpose, or function of something" with examples like "convert lead into gold" also fits but sense 2 is more about changing function, while sense 11 specifically mentions "undergo a chemical change". The context says "converted into an active form" which is a chemical change. So sense 11 is best. However, note that sense keys have numbers. The candidate list shows sense 11 as index 11? Actually the list: 1 through 11. The last one is sense 11: "convert%2:30:04::" with definition "change in nature, purpose, or function; undergo a chemical change". That is most appropriate. So answer should be {"sense_index": 11}. But check: there is also sense 2: "change the nature, purpose, or function of something" but that doesn't explicitly mention chemical change. The example "convert lead into gold" is alchemy, but still a chemical change? Actually it's a transformation. But sense 11 is more specific to chemical change. Since the context is about a drug being converted into active form, it's a chemical process. So sense 11 is best.{"sense_index": 11}

[User] Your previous answer was invalid. Choose one candidate index between 1 and 11. Return only valid JSON exactly like {"sense_index": 1}.

finish_reason: stop

role: assistant

reasoning_content: We need to choose the best sense for "converted" in context: "pemetrexed is converted into an active form that blocks the activity of the enzymes..." This is a chemical change. Among the senses, sense 11 is defined as "change in nature, purpose, or function; undergo a chemical change" with example "The substance converts to an acid." That fits perfectly. Sense 2 is "change the nature, purpose, or function of something" but doesn't specifically mention chemical change, though "convert lead into gold" is a chemical transformation. However, sense 11 explicitly includes "undergo a chemical change." So sense 11 is the best. But the user says my previous answer was invalid, and asks to choose between 1 and 11. Perhaps the indexing is off? The list shows 11 senses, numbered 1 through 11. I previously answered {"sense_index": 11}. That should be valid. But maybe the system expects a different format? Let me re-read: "Return only a valid JSON exactly like {"sense_index": 1}". So I need to output the number. I'll stick with 11.

format: unknown

native_finish_reason: stop

provider: Parasail

currency: USD


attempt_kind: initial

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
7. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
13. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need to choose the best sense for "active" in the context: "pemetrexed is converted into an active form that blocks the activity of the enzymes..." The phrase "active form" refers to a form that exerts influence or produces a change or effect, i.e., the substance becomes chemically active. Sense 6: "exerting influence or producing a change or effect" with example "an active ingredient" matches perfectly. Also sense 6 is defined as "exerting influence or producing a change or effect". The context is about a drug being converted into a form that blocks enzymes, so it's producing a change. So sense_index 6.

provider: GMICloud


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: form
Target surface form: form
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=form%1:10:00:: | definition=the phonological or orthographic sound or appearance of a word that can be used to describe or identify something | synonyms=word form, signifier, descriptor | examples=the inflected forms of a word can be represented by a stem and a list of inflections to be attached
2. sense_key=form%1:09:01:: | definition=a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety | examples=sculpture is a form of art; what kinds of desserts are there?
3. sense_key=form%1:09:00:: | definition=a perceptual structure | synonyms=shape, pattern | examples=the composition presents problems for students of musical form; a visual pattern must include not only objects but the spaces between them
4. sense_key=form%1:07:01:: | definition=any spatial attributes (especially as defined by outline) | synonyms=shape, configuration, contour, conformation | examples=he could barely make out their shapes
5. sense_key=form%1:08:00:: | definition=alternative names for the body of a human being | synonyms=human body, physical body, material body, soma, build, figure | examples=Leonardo studied the human body; he has a strong physique
6. sense_key=form%1:03:00:: | definition=the spatial arrangement of something as distinct from its substance | synonyms=shape | examples=geometry is the mathematical science of shape
7. sense_key=form%1:07:00:: | definition=the visual appearance of something or someone | synonyms=shape, cast | examples=the delicate cast of his features
8. sense_key=form%1:10:01:: | definition=a printed document with spaces in which to write | examples=he filled out his tax form
9. sense_key=form%1:14:02:: | definition=(biology) a group of organisms within a species that differ in trivial ways from similar groups | synonyms=variant, strain, var. | examples=a new strain of microorganisms
10. sense_key=form%1:10:02:: | definition=an arrangement of the elements in a composition or discourse | examples=the essay was in the form of a dialogue; he first sketches the plot in outline form
11. sense_key=form%1:07:03:: | definition=a particular mode in which something is manifested | examples=his resentment took the form of extreme hostility
12. sense_key=form%1:26:00:: | definition=(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary | synonyms=phase | examples=the reaction occurs in the liquid phase of the system
13. sense_key=form%1:14:00:: | definition=a body of students who are taught together | synonyms=class, grade, course | examples=early morning classes are always sleepy
14. sense_key=form%1:07:02:: | definition=an ability to perform well | examples=he was at the top of his form; the team was off form last night
15. sense_key=form%1:06:00:: | definition=a life-size dummy used to display clothes | synonyms=mannequin, manikin, mannikin, manakin
16. sense_key=form%1:06:01:: | definition=a mold for setting concrete | examples=they built elaborate forms for pouring the foundation

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We are given the sentence: "In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides..." The word "form" here refers to a particular mode or state in which something is manifested. Specifically, the active form of the drug means the chemical state or configuration that is biologically active. Sense 11: "a particular mode in which something is manifested" fits perfectly. Sense 12 (phase) might also be considered, but "form" here is not about physical state (solid/liquid/gas) but about an active variant of the molecule. Sense 2 (kind/sort) is also plausible, but sense 11 is more precise because it refers to a mode of manifestation. Also, the example "his resentment took the form of extreme hostility" aligns with the idea of converting into an active form. Therefore, sense index 11 is best.

provider: Baidu


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: block
Target surface form: blocks
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=block%2:35:00:: | definition=render unsuitable for passage | synonyms=barricade, blockade, stop, block off, block up, bar | examples=block the way; barricade the streets
2. sense_key=block%2:41:00:: | definition=hinder or prevent the progress or accomplishment of | synonyms=obstruct, blockade, hinder, stymie, stymy, embarrass | examples=His brother blocked him at every turn
3. sense_key=block%2:41:01:: | definition=stop from happening or developing | synonyms=stop, halt, kibosh | examples=Block his election; Halt the process
4. sense_key=block%2:32:00:: | definition=interfere with or prevent the reception of signals | synonyms=jam | examples=Jam the Voice of America; block the signals emitted by this station
5. sense_key=block%2:41:03:: | definition=run on a block system | examples=block trains
6. sense_key=block%2:39:05:: | definition=interrupt the normal function of by means of anesthesia | examples=block a nerve; block a muscle
7. sense_key=block%2:39:00:: | definition=shut out from view or get in the way so as to hide from sight | synonyms=obstruct | examples=The thick curtain blocked the action on the stage; The trees obstruct my view of the mountains
8. sense_key=block%2:35:03:: | definition=stamp or emboss a title or design on a book with a block | examples=block the book cover
9. sense_key=block%2:35:02:: | definition=obstruct | synonyms=stuff, lug, choke up | examples=My nose is all stuffed; Her arteries are blocked
10. sense_key=block%2:35:12:: | definition=block passage through | synonyms=obstruct, obturate, impede, occlude, jam, close up | examples=obstruct the path
11. sense_key=block%2:35:06:: | definition=support, secure, or raise with a block | examples=block a plate for printing; block the wheels of a car
12. sense_key=block%2:33:00:: | definition=impede the movement of (an opponent or a ball) | synonyms=parry, deflect | examples=block an attack
13. sense_key=block%2:31:00:: | definition=be unable to remember | synonyms=forget, blank out, draw a blank | examples=I'm drawing a blank; You are blocking the name of your first wife!
14. sense_key=block%2:30:01:: | definition=shape by using a block | examples=Block a hat; block a garment
15. sense_key=block%2:30:00:: | definition=shape into a block or blocks | examples=block the graphs so one can see the results clearly
16. sense_key=block%2:30:02:: | definition=prohibit the conversion or use of (assets) | synonyms=freeze, immobilize, immobilise | examples=Blocked funds; Freeze the assets of this hostile government

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We are given the target word "blocks" in context: "pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides". The context is about a drug that inhibits enzyme activity. Among the senses, we need to find the one that best matches "prevents the activity of enzymes". Sense 3: "stop from happening or developing" with synonyms "stop, halt, kibosh" and example "Block his election; Halt the process". That fits well: the drug blocks (stops) the activity of enzymes. Sense 2: "hinder or prevent the progress or accomplishment of" also fits, but the example "His brother blocked him at every turn" is more about obstructing a person's efforts. Sense 1 is about physical passage, sense 4 about signals, sense 9 about obstruction of passages like arteries, sense 10 about block passage through, etc. The context is about enzymatic activity, which is a process. Sense 3 explicitly says "stop from happening or developing" which matches blocking enzyme activity. Therefore, sense_index 3 is best.

provider: Morph


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: involved
Target surface form: involved
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=involved%3:00:00:: | definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved; the problems involved
2. sense_key=involved%5:00:00:encumbered:00 | definition=entangled or hindered as if e.g. in mire | synonyms=mired | examples=the difficulties in which the question is involved; brilliant leadership mired in details and confusion
3. sense_key=involved%5:00:00:attached:01 | definition=emotionally involved
4. sense_key=involved%5:00:00:complex:00 | definition=highly complex or intricate and occasionally devious; ; ; ; ; ; ; ; - Sir Walter Scott | synonyms=Byzantine, convoluted, knotty, tangled, tortuous | examples=the Byzantine tax structure; Byzantine methods for holding on to his chairmanship
5. sense_key=involved%5:00:00:enclosed:00 | definition=enveloped | examples=a castle involved in mist; the difficulties in which the question is involved

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We are given the target lemma "involved" in the context: "blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides". This describes enzymes that participate in a process. The sense should be about participation or association. Sense 1 is "connected by participation or association or use" with examples that include "the problems involved". That fits. Sense 2 is about being entangled or hindered, which doesn't fit. Sense 3 is emotionally involved, not applicable. Sense 4 is complex/intricate, not applicable. Sense 5 is enveloped, not applicable. So the best sense is 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: produce
Target surface form: producing
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in <t>producing</t> nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=produce%2:36:02:: | definition=bring forth or yield | synonyms=bring forth | examples=The tree would not produce fruit
2. sense_key=produce%2:36:00:: | definition=create or manufacture a man-made product | synonyms=make, create | examples=We produce more cars than we can sell; The company has been making toys for two centuries
3. sense_key=produce%2:36:03:: | definition=cause to happen, occur or exist | synonyms=bring about, give rise | examples=This procedure produces a curious effect; The new law gave rise to many complaints
4. sense_key=produce%2:39:01:: | definition=bring out for display | synonyms=bring forth | examples=The proud father produced many pictures of his baby; The accused brought forth a letter in court that he claims exonerates him
5. sense_key=produce%2:36:05:: | definition=cultivate by growing, often involving improvements by means of agricultural techniques | synonyms=grow, raise, farm | examples=The Bordeaux region produces great red wines; They produce good ham in Parma
6. sense_key=produce%2:39:00:: | definition=bring onto the market or release | synonyms=bring on, bring out | examples=produce a movie; bring out a book
7. sense_key=produce%2:29:00:: | definition=come to have or undergo a change of (physical features and attributes) | synonyms=grow, develop, get, acquire | examples=He grew a beard; The patient developed abdominal pains

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We need to determine the correct sense of "producing" in the context: "blocking the activity of the enzymes that are involved in producing nucleotides". The target is about the biological process of creating nucleotides. Let's review candidate senses:

1. bring forth or yield (like fruit) - not quite, because it's about biological production but more like yielding fruit.
2. create or manufacture a man-made product - nucleotides are not man-made in this context; they are created by enzymes in the body.
3. cause to happen, occur or exist - this could fit as the enzymes cause nucleotides to exist.
4. bring out for display - no.
5. cultivate by growing - agricultural, not biological molecular.
6. bring onto the market or release - no.
7. come to have or undergo a change - like growing a beard, not exactly.

The best fit is sense 3: cause to happen, occur or exist. The enzymes cause the existence of nucleotides. The example "This procedure produces a curious effect" shows a similar causative meaning. So sense index 3.

provider: Alibaba


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: building_block
Target surface form: building blocks
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the <t>building blocks</t> of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=building_block%1:17:00:: | definition=a single undivided natural thing occurring in the composition of something else | synonyms=unit | examples=units of nucleic acids
2. sense_key=building_block%1:06:00:: | definition=a block of material used in construction work

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need to choose between sense 1 and sense 2. The context: "nucleotides (the building blocks of DNA and RNA)". This refers to the fundamental components of DNA/RNA, i.e., units. Sense 1: "a single undivided natural thing occurring in the composition of something else" with example "units of nucleic acids". That matches perfectly. Sense 2 is about construction material. So sense 1 is correct. The answer should be {"sense_index": 1}.

provider: Cloudflare


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: genetic
Target surface form: genetic
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the <t>genetic</t> material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=genetic%5:00:00:inheritable:00 | definition=occurring among members of a family usually by heredity | synonyms=familial, hereditary, inherited, transmitted, transmissible | examples=an inherited disease; familial traits
2. sense_key=genetic%3:01:02:: | definition=of or relating to or produced by or being a gene | synonyms=genic, genetical | examples=genic combinations; genetic code
3. sense_key=genetic%3:01:01:: | definition=pertaining to or referring to origin | examples=genetic history reconstructs the origins of a literary work
4. sense_key=genetic%3:01:00:: | definition=of or relating to the science of genetics | synonyms=genetical | examples=genetic research

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We need to determine the correct sense of "genetic" in the context. The phrase is "the genetic material of cells". This refers to DNA and RNA, which are the hereditary material. The context says "producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)." So it's referring to the material that carries genetic information. Among the senses:

Sense 1: occurring among members of a family usually by heredity - not directly about material, more about familial traits.

Sense 2: of or relating to or produced by or being a gene - this fits well because genetic material is the material of genes. Synonyms: genic, genetical. Example: "genetic code" is analogous to genetic material.

Sense 3: pertaining to or referring to origin - not relevant here.

Sense 4: of or relating to the science of genetics - broader, but the context is about the material itself, not the science.

Thus sense 2 is best. So index = 2.

provider: AtlasCloud


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: material
Target surface form: material
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic <t>material</t> of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=material%1:27:00:: | definition=the tangible substance that goes into the makeup of a physical object | synonyms=stuff | examples=coal is a hard black material; wheat is the stuff they use to make bread
2. sense_key=material%1:10:00:: | definition=information (data or ideas or observations) that can be used or reworked into a finished form | examples=the archives provided rich material for a definitive biography
3. sense_key=material%1:06:00:: | definition=artifact made by weaving or felting or knitting or crocheting natural or synthetic fibers | synonyms=fabric, cloth, textile | examples=the fabric in the curtains was light and semitransparent; woven cloth originated in Mesopotamia around 5000 BC
4. sense_key=material%1:06:01:: | definition=things needed for doing or making something | examples=writing materials; useful teaching materials
5. sense_key=material%1:18:00:: | definition=a person judged suitable for admission or employment | examples=he was university material; she was vice-presidential material

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
We are given the sentence: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)." The target word is "material" and it appears in the phrase "the genetic material of cells". Here, "genetic material" refers to DNA and RNA, which are the substances that carry genetic information. This is not about physical substance used in making objects (sense 1), nor information/data (sense 2), nor fabric (sense 3), nor things needed for doing something (sense 4), nor a person suitable for employment (sense 5). The term "genetic material" is a standard biological term meaning the DNA and RNA that carry genetic information. However, looking at the definitions: sense 1 says "the tangible substance that goes into the makeup of a physical object". DNA and RNA are tangible substances that make up the genetic material. The synonyms include "stuff". The example "coal is a hard black material" is similar. This seems to fit best. Sense 2 is about information, but genetic material is not just information; it is the physical molecule. Sense 1 is about the physical substance. So sense 1 is the best match.

Thus, the sense index is 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cells
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of <t>cells</t>). How has Alimta been studied?

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We are given a target surface form "cells" in a context about Alimta (pemetrexed) and its mechanism of action. The context mentions "cells that are dividing, such as cancer cells" and "the genetic material of cells". Clearly, this is referring to biological cells, the basic structural and functional unit of organisms. Sense 2 is the biological sense. The other senses (compartments, electric cell, political unit, mobile phone, monk's room, prison cell) do not fit. So the best sense is index 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: study
Target surface form: studied
Context:
Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been <t>studied</t>? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before.

Candidate senses:
1. sense_key=study%2:31:02:: | definition=consider in detail and subject to an analysis in order to discover essential features or meaning | synonyms=analyze, analyse, examine, canvass, canvas | examples=analyze a sonnet by Shakespeare; analyze the evidence in a criminal trial
2. sense_key=study%2:31:03:: | definition=be a student; follow a course of study; be enrolled at an institute of learning
3. sense_key=study%2:39:00:: | definition=give careful consideration to | synonyms=consider | examples=consider the possibility of moving
4. sense_key=study%2:31:00:: | definition=be a student of a certain subject | synonyms=learn, read, take | examples=She is reading for the bar exam
5. sense_key=study%2:31:01:: | definition=learn by reading books | synonyms=hit the books | examples=He is studying geology in his room; I have an exam next week; I must hit the books now
6. sense_key=study%2:31:04:: | definition=think intently and at length, as for spiritual purposes | synonyms=meditate, contemplate | examples=He is meditating in his study

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We are given: "How has Alimta been <t>studied</t>?" The context is about a medical study: "Alimta has been studied in one main study in 456 patients..." This clearly refers to conducting a clinical trial or investigation. Among the senses: sense 1 is "consider in detail and subject to an analysis", which fits clinical research. Sense 2,3,4,5,6 are about being a student, learning, meditating, etc. The best match is sense 1 (analyze, examine). So sense_index=1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: treatment
Target surface form: treatment
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the <t>treatment</t> of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=treatment%1:04:00:: | definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) | synonyms=intervention
2. sense_key=treatment%1:04:01:: | definition=the management of someone or something | synonyms=handling | examples=the handling of prisoners; the treatment of water sewage
3. sense_key=treatment%1:07:00:: | definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture
4. sense_key=treatment%1:10:00:: | definition=an extended communication (often interactive) dealing with some particular topic | synonyms=discussion, discourse | examples=the book contains an excellent discussion of modal logic; his treatment of the race question is badly biased

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We are given: "For the <t>treatment</t> of malignant pleural mesothelioma, Alimta has been studied..." The context is medical: treatment of a disease. This matches sense 1: "care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)". The synonyms include "intervention". So sense 1 is the best.

provider: DigitalOcean


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: study
Target surface form: studied
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been <t>studied</t> in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=study%2:31:02:: | definition=consider in detail and subject to an analysis in order to discover essential features or meaning | synonyms=analyze, analyse, examine, canvass, canvas | examples=analyze a sonnet by Shakespeare; analyze the evidence in a criminal trial
2. sense_key=study%2:31:03:: | definition=be a student; follow a course of study; be enrolled at an institute of learning
3. sense_key=study%2:39:00:: | definition=give careful consideration to | synonyms=consider | examples=consider the possibility of moving
4. sense_key=study%2:31:00:: | definition=be a student of a certain subject | synonyms=learn, read, take | examples=She is reading for the bar exam
5. sense_key=study%2:31:01:: | definition=learn by reading books | synonyms=hit the books | examples=He is studying geology in his room; I have an exam next week; I must hit the books now
6. sense_key=study%2:31:04:: | definition=think intently and at length, as for spiritual purposes | synonyms=meditate, contemplate | examples=He is meditating in his study

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We are given the target word "studied" in the context: "How has Alimta been studied? ... Alimta has been studied in one main study ..." The context is about a clinical trial or research study. The sense here is about conducting a scientific investigation, not about a student studying. Among the candidate senses, sense 1 (study%2:31:02::) is about analyzing or examining in detail to discover essential features or meaning. That fits the context of a clinical study. The other senses are about being a student, considering, or meditating. So the best sense is sense 1. But we need to return the sense_index. In the list, sense 1 corresponds to index 1. However, in the JSON example they gave {"sense_index": 3}, which is just an example. So we will return {"sense_index": 1}.

provider: WandB


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: main
Target surface form: main
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one <t>main</t> study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=main%5:00:00:important:00 | definition=most important element | synonyms=chief, primary, principal, master | examples=the chief aim of living; the main doors were of solid glass
2. sense_key=main%3:00:02:: | definition=(of a clause) capable of standing syntactically alone as a complete sentence | synonyms=independent | examples=the main (or independent) clause in a complex sentence has at least a subject and a verb
3. sense_key=main%5:00:00:intense:00 | definition=of force; of the greatest possible intensity | examples=by main strength

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We are given a target word "main" in a context about a medical study. The sentence says: "For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients..." The word "main" here modifies "study" and means it is the primary or most important study among others. This matches sense 1: "most important element" with synonyms chief, primary, principal. Sense 2 is about grammatical clauses, not relevant. Sense 3 is about intensity of force ("by main strength"), which does not fit. So the best sense is index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: study
Target surface form: study
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main <t>study</t> in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=study%1:04:00:: | definition=a detailed critical inspection | synonyms=survey
2. sense_key=study%1:09:03:: | definition=applying the mind to learning and understanding a subject (especially by reading) | synonyms=work | examples=mastering a second language requires a lot of work; no schools offer graduate study in interior design
3. sense_key=study%1:10:00:: | definition=a written document describing the findings of some individual or group | synonyms=report, written report | examples=this accords with the recent study by Hill and Dale
4. sense_key=study%1:09:04:: | definition=a state of deep mental absorption | examples=she is in a deep study
5. sense_key=study%1:06:00:: | definition=a room used for reading and writing and studying | examples=he knocked lightly on the closed door of the study
6. sense_key=study%1:09:02:: | definition=a branch of knowledge | synonyms=discipline, subject, subject area, subject field, field, field of study | examples=in what discipline is his doctorate?; teachers should be well trained in their subject
7. sense_key=study%1:06:01:: | definition=preliminary drawing for later elaboration | synonyms=sketch | examples=he made several studies before starting to paint
8. sense_key=study%1:09:01:: | definition=attentive consideration and meditation | synonyms=cogitation | examples=after much cogitation he rejected the offer
9. sense_key=study%1:18:00:: | definition=someone who memorizes quickly and easily (as the lines for a part in a play) | examples=he is a quick study
10. sense_key=study%1:10:01:: | definition=a composition intended to develop one aspect of the performer's technique | examples=a study in spiccato bowing

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
We are given a context: "How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main <t>study</t> in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone."

The target word is "study" in the phrase "one main study". It refers to a clinical trial or a research study. Among the candidate senses:

1. sense_key=study%1:04:00:: | definition=a detailed critical inspection | synonyms=survey
2. sense_key=study%1:09:03:: | definition=applying the mind to learning and understanding a subject (especially by reading) | synonyms=work
3. sense_key=study%1:10:00:: | definition=a written document describing the findings of some individual or group | synonyms=report, written report
4. sense_key=study%1:09:04:: | definition=a state of deep mental absorption
5. sense_key=study%1:06:00:: | definition=a room used for reading and writing and studying
6. sense_key=study%1:09:02:: | definition=a branch of knowledge
7. sense_key=study%1:06:01:: | definition=preliminary drawing for later elaboration
8. sense_key=study%1:09:01:: | definition=attentive consideration and meditation
9. sense_key=study%1:18:00:: | definition=someone who memorizes quickly and easily
10. sense_key=study%1:10:01:: | definition=a composition intended to develop one aspect of the performer's technique

The context is about a clinical trial or research study. It is a specific investigation, typically a "study" as a research project. Sense 1: "a detailed critical inspection" might fit, but sense 3: "a written document describing the findings" also fits, but here it's described as "one main study" in 456 patients, which is likely referring to the actual research project (the clinical trial) rather than the written report. However, the phrase "study" is used as a noun to refer to the research project itself. In medical contexts, "study" often refers to a clinical trial or research study. Sense 1: "a detailed critical inspection" (survey) might be a bit too broad. Sense 3: "a written document" is more specific, but here it's not necessarily the document; it's the research study. The example for sense 3: "this accords with the recent study by Hill and Dale" often refers to a research project or its report. In common usage, "study" can mean both the research and the report. But given the context: "Alimta has been studied in one main study" - the word "study" here refers to the research investigation, not the written document. However, the sense "a detailed critical inspection" (sense 1) might also work. Let's check the synonyms: "survey" for sense 1. A survey is a type of study, but not exactly a clinical trial. The context is a clinical trial. Sense 3: "report, written report" is more about the document. But the sentence says "in one main study" which implies the research itself. Often in medical literature, "study" refers to a clinical trial. I think sense 1 is broader. But also note sense 8: "attentive consideration and meditation" doesn't fit. Sense 2: "applying the mind to learning" is more like studying as an activity. So the best is likely sense 1 or sense 3. Let's examine WordNet gloss: 1: "a detailed critical inspection" - that could be a clinical trial where you inspect the effects. But the example for sense 1 is not given. For sense 3, the example: "this accords with the recent study by Hill and Dale" - that is typically a research report. However, "study" can also refer to the research itself. In many contexts, "study" as a noun can mean a research project. I think sense 1 is more appropriate because it's about inspection, but sense 3 is about a document. However, the phrase "one main study" suggests a specific research project. I'll go with sense 3 because it's often used to refer to a research study in scientific contexts. But let's see the definition: "a written document describing the findings" - that is a report. But here, it's the study itself, not the document. Often people say "a study" meaning the research. In fact, WordNet has sense "study%1:04:00::" with "survey" - that might be closer to "study" as in "clinical study". Actually, a "survey" is a type of study. But I think sense 3 is more common for a clinical trial. However, I need to be precise. Another clue: the context says "How has Alimta been studied?" and then "Alimta has been studied in one main study". That is a bit redundant, but the word "study" here is the same as the verb "studied". The verb "studied" could lead to noun "study" meaning the research. I think sense 1 is "a detailed critical inspection" - that fits the idea of a clinical trial where you inspect the effects. But sense 3 is more about the report. Given that the sentence says "in one main study" and then "456 patients", it is the actual trial, not a report. However, often the report is also called a study. I'll check the examples: for sense 3, "this accords with the recent study by Hill and Dale" - that is usually a reference to a published paper, but the study itself is the research. So it's ambiguous. I think sense 1 might be better: "a detailed critical inspection" - like a survey, but a clinical trial is a type of inspection. However, I recall that in WordNet, the sense for clinical trial might be under "study" as a noun. Actually, sense 1 is "survey" which is a type of study, but not necessarily the same as a clinical trial. Sense 3 is "report" which is a document. I think the most common sense for "study" in the context of a clinical trial is sense 1 (critical inspection) because you are inspecting the effects. But let's see the synonyms: survey. A clinical trial is not typically called a survey. It's called a trial or study. I'm leaning towards sense 3 because it's a written document, but the context says "in one main study" - that is the research itself, not just the document. Perhaps sense 1 is more appropriate because it refers to the act of inspecting. Actually, the definition for sense 1: "a detailed critical inspection" - that could be a clinical trial. The example for sense 1 is not given. For sense 3, the example is about a study by Hill and Dale - that is typically a research paper. But in common language, "study" can refer to both. I think sense 3 is more specific to a research study as a document. However, the sentence "Alimta has been studied in one main study" - the first "studied" is verb, the second "study" is noun. The noun "study" here refers to the research project, not the document. So I think sense 1 is the best: a detailed critical inspection (of the drug). Alternatively, sense 9 and 10 are clearly wrong. So I'll go with sense 1.

But wait, there is also sense 8: "attentive consideration and meditation" - no. So between 1 and 3, I think 1 is more accurate for a clinical trial. However, "study" as in "a study" is often used to mean a research project, and WordNet might categorize that under "study%1:04:00::" as "survey"? Actually, survey is a broad term. In medical contexts, "study" is a type of research. I think sense 3 is "report, written report" which is the output, not the process. The process is more like "study" as in "research study". So I'll choose sense 1.

Let's double-check the context: "How has Alimta been studied? ... in one main study ..." - the study is the actual clinical trial. So sense 1: "a detailed critical inspection" - that fits. Sense 3: "a written document" - that would be the report of the study, but the study itself is the trial. So I think sense 1 is better.

Thus, answer: {"sense_index": 1}{"sense_index": 1}

provider: Wafer


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: study
Target surface form: study
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main <t>study</t> in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=study%1:04:00:: | definition=a detailed critical inspection | synonyms=survey
2. sense_key=study%1:09:03:: | definition=applying the mind to learning and understanding a subject (especially by reading) | synonyms=work | examples=mastering a second language requires a lot of work; no schools offer graduate study in interior design
3. sense_key=study%1:10:00:: | definition=a written document describing the findings of some individual or group | synonyms=report, written report | examples=this accords with the recent study by Hill and Dale
4. sense_key=study%1:09:04:: | definition=a state of deep mental absorption | examples=she is in a deep study
5. sense_key=study%1:06:00:: | definition=a room used for reading and writing and studying | examples=he knocked lightly on the closed door of the study
6. sense_key=study%1:09:02:: | definition=a branch of knowledge | synonyms=discipline, subject, subject area, subject field, field, field of study | examples=in what discipline is his doctorate?; teachers should be well trained in their subject
7. sense_key=study%1:06:01:: | definition=preliminary drawing for later elaboration | synonyms=sketch | examples=he made several studies before starting to paint
8. sense_key=study%1:09:01:: | definition=attentive consideration and meditation | synonyms=cogitation | examples=after much cogitation he rejected the offer
9. sense_key=study%1:18:00:: | definition=someone who memorizes quickly and easily (as the lines for a part in a play) | examples=he is a quick study
10. sense_key=study%1:10:01:: | definition=a composition intended to develop one aspect of the performer's technique | examples=a study in spiccato bowing

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

[Assistant]
We are given a context: "How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main <t>study</t> in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone."

The target word is "study" in the phrase "one main study". It refers to a clinical trial or a research study. Among the candidate senses:

1. sense_key=study%1:04:00:: | definition=a detailed critical inspection | synonyms=survey
2. sense_key=study%1:09:03:: | definition=applying the mind to learning and understanding a subject (especially by reading) | synonyms=work
3. sense_key=study%1:10:00:: | definition=a written document describing the findings of some individual or group | synonyms=report, written report
4. sense_key=study%1:09:04:: | definition=a state of deep mental absorption
5. sense_key=study%1:06:00:: | definition=a room used for reading and writing and studying
6. sense_key=study%1:09:02:: | definition=a branch of knowledge
7. sense_key=study%1:06:01:: | definition=preliminary drawing for later elaboration
8. sense_key=study%1:09:01:: | definition=attentive consideration and meditation
9. sense_key=study%1:18:00:: | definition=someone who memorizes quickly and easily
10. sense_key=study%1:10:01:: | definition=a composition intended to develop one aspect of the performer's technique

The context is about a clinical trial or research study. It is a specific investigation, typically a "study" as a research project. Sense 1: "a detailed critical inspection" might fit, but sense 3: "a written document describing the findings" also fits, but here it's described as "one main study" in 456 patients, which is likely referring to the actual research project (the clinical trial) rather than the written report. However, the phrase "study" is used as a noun to refer to the research project itself. In medical contexts, "study" often refers to a clinical trial or research study. Sense 1: "a detailed critical inspection" (survey) might be a bit too broad. Sense 3: "a written document" is more specific, but here it's not necessarily the document; it's the research study. The example for sense 3: "this accords with the recent study by Hill and Dale" often refers to a research project or its report. In common usage, "study" can mean both the research and the report. But given the context: "Alimta has been studied in one main study" - the word "study" here refers to the research investigation, not the written document. However, the sense "a detailed critical inspection" (sense 1) might also work. Let's check the synonyms: "survey" for sense 1. A survey is a type of study, but not exactly a clinical trial. The context is a clinical trial. Sense 3: "report, written report" is more about the document. But the sentence says "in one main study" which implies the research itself. Often in medical literature, "study" refers to a clinical trial. I think sense 1 is broader. But also note sense 8: "attentive consideration and meditation" doesn't fit. Sense 2: "applying the mind to learning" is more like studying as an activity. So the best is likely sense 1 or sense 3. Let's examine WordNet gloss: 1: "a detailed critical inspection" - that could be a clinical trial where you inspect the effects. But the example for sense 1 is not given. For sense 3, the example: "this accords with the recent study by Hill and Dale" - that is typically a research report. However, "study" can also refer to the research itself. In many contexts, "study" as a noun can mean a research project. I think sense 1 is more appropriate because it's about inspection, but sense 3 is about a document. However, the phrase "one main study" suggests a specific research project. I'll go with sense 3 because it's often used to refer to a research study in scientific contexts. But let's see the definition: "a written document describing the findings" - that is a report. But here, it's the study itself, not the document. Often people say "a study" meaning the research. In fact, WordNet has sense "study%1:04:00::" with "survey" - that might be closer to "study" as in "clinical study". Actually, a "survey" is a type of study. But I think sense 3 is more common for a clinical trial. However, I need to be precise. Another clue: the context says "How has Alimta been studied?" and then "Alimta has been studied in one main study". That is a bit redundant, but the word "study" here is the same as the verb "studied". The verb "studied" could lead to noun "study" meaning the research. I think sense 1 is "a detailed critical inspection" - that fits the idea of a clinical trial where you inspect the effects. But sense 3 is more about the report. Given that the sentence says "in one main study" and then "456 patients", it is the actual trial, not a report. However, often the report is also called a study. I'll check the examples: for sense 3, "this accords with the recent study by Hill and Dale" - that is usually a reference to a published paper, but the study itself is the research. So it's ambiguous. I think sense 1 might be better: "a detailed critical inspection" - like a survey, but a clinical trial is a type of inspection. However, I recall that in WordNet, the sense for clinical trial might be under "study" as a noun. Actually, sense 1 is "survey" which is a type of study, but not necessarily the same as a clinical trial. Sense 3 is "report" which is a document. I think the most common sense for "study" in the context of a clinical trial is sense 1 (critical inspection) because you are inspecting the effects. But let's see the synonyms: survey. A clinical trial is not typically called a survey. It's called a trial or study. I'm leaning towards sense 3 because it's a written document, but the context says "in one main study" - that is the research itself, not just the document. Perhaps sense 1 is more appropriate because it refers to the act of inspecting. Actually, the definition for sense 1: "a detailed critical inspection" - that could be a clinical trial. The example for sense 1 is not given. For sense 3, the example is about a study by Hill and Dale - that is typically a research paper. But in common language, "study" can refer to both. I think sense 3 is more specific to a research study as a document. However, the sentence "Alimta has been studied in one main study" - the first "studied" is verb, the second "study" is noun. The noun "study" here refers to the research project, not the document. So I think sense 1 is the best: a detailed critical inspection (of the drug). Alternatively, sense 9 and 10 are clearly wrong. So I'll go with sense 1.

But wait, there is also sense 8: "attentive consideration and meditation" - no. So between 1 and 3, I think 1 is more accurate for a clinical trial. However, "study" as in "a study" is often used to mean a research project, and WordNet might categorize that under "study%1:04:00::" as "survey"? Actually, survey is a broad term. In medical contexts, "study" is a type of research. I think sense 3 is "report, written report" which is the output, not the process. The process is more like "study" as in "research study". So I'll choose sense 1.

Let's double-check the context: "How has Alimta been studied? ... in one main study ..." - the study is the actual clinical trial. So sense 1: "a detailed critical inspection" - that fits. Sense 3: "a written document" - that would be the report of the study, but the study itself is the trial. So I think sense 1 is better.

Thus, answer: {"sense_index": 1}{"sense_index": 1}

[User] Your previous answer was invalid. Choose one candidate index between 1 and 10. Return only valid JSON exactly like {"sense_index": 1}.

reasoning_content:
We need to choose the best sense for "study" in the given context. The context describes a clinical trial: "Alimta has been studied in one main study in 456 patients." This is a research study, a clinical investigation. Among the senses:

1. "a detailed critical inspection" (survey) - could fit, but "survey" is not exactly a clinical trial.
2. "applying the mind to learning and understanding a subject (especially by reading)" - not applicable.
3. "a written document describing the findings of some individual or group" - this is a report, but the context says "study" as the investigation itself.
4. "a state of deep mental absorption" - no.
5. "a room used for reading and writing and studying" - no.
6. "a branch of knowledge" - no.
7. "preliminary drawing for later elaboration" - no.
8. "attentive consideration and meditation" - no.
9. "someone who memorizes quickly and easily" - no.
10. "a composition intended to develop one aspect of the performer's technique" - no.

The best fit is sense 1: "a detailed critical inspection". In medical research, a "study" is indeed a systematic investigation. Sense 3 is about the document, not the investigation itself. The context refers to the actual clinical trial. So sense_index is 1.

provider: Io Net


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 <t>patients</t> who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need to choose between sense 1 (person requiring medical care) and sense 2 (semantic role). The context is about a medical treatment study involving patients with mesothelioma. Clearly, "patients" refers to people receiving medical care. So sense 1 is correct.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: before
Target surface form: before
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease <t>before</t>. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=before%4:02:03:: | definition=earlier in time; previously | synonyms=earlier | examples=I had known her before; as I said before
2. sense_key=before%4:02:01:: | definition=at or in the front | synonyms=ahead, in front | examples=I see the lights of a town ahead; the road ahead is foggy

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need to choose between two senses. The context: "456 patients who had not received chemotherapy for their disease <t>before</t>." This means earlier in time, previously. The second sense is about spatial front. So sense 1 is correct.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: effect
Target surface form: effects
Context:
How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The <t>effects</t> of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past.

Candidate senses:
1. sense_key=effect%1:19:00:: | definition=a phenomenon that follows and is caused by some previous phenomenon | synonyms=consequence, outcome, result, event, issue, upshot | examples=the magnetic effect was greater when the rod was lengthwise; his decision had depressing consequences for business
2. sense_key=effect%1:07:00:: | definition=an outward appearance | synonyms=impression | examples=he made a good impression; I wanted to create an impression of success
3. sense_key=effect%1:09:00:: | definition=an impression (especially one that is artificial or contrived) | examples=he just did it for effect
4. sense_key=effect%1:10:00:: | definition=the central meaning or theme of a speech or literary work | synonyms=essence, burden, core, gist
5. sense_key=effect%1:07:01:: | definition=(of a law) having legal validity | synonyms=force | examples=the law is still in effect
6. sense_key=effect%1:26:00:: | definition=a symptom caused by an illness or a drug | examples=the effects of sleep loss; the effect of the anesthetic

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need to choose the best sense for "effects" in the given context. The context discusses the Alimta drug and its effects compared to other treatments. The target phrase is "The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone." Also later: "the effects of Alimta were compared with those of docetaxel." Here "effects" refers to outcomes or results of the treatment, specifically the therapeutic outcomes or consequences. This aligns with sense 1: "a phenomenon that follows and is caused by some previous phenomenon" (synonyms: consequence, outcome, result). Sense 6: "a symptom caused by an illness or a drug" could also be plausible, but the context is about comparing efficacy in clinical studies, not just symptoms. The examples for sense 6 are "the effects of sleep loss; the effect of the anesthetic" which are more about specific symptoms. But in the text, they are comparing overall outcomes (e.g., effects on disease). Sense 1 is more general and fits better. Also note the synonyms: consequence, outcome, result. The word "effects" here means the results or outcomes of the drug. So sense 1 is best.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: compare
Target surface form: compared
Context:
How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were <t>compared</t> with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past.

Candidate senses:
1. sense_key=compare%2:31:00:: | definition=examine and note the similarities or differences of | examples=John compared his haircut to his friend's; We compared notes after we had both seen the movie
2. sense_key=compare%2:42:00:: | definition=be comparable | examples=This car does not compare with our line of Mercedes
3. sense_key=compare%2:31:01:: | definition=consider or describe as similar, equal, or analogous | synonyms=liken, equate | examples=We can compare the Han dynasty to the Romans; You cannot equate success in financial matters with greed
4. sense_key=compare%2:32:00:: | definition=to form the comparative or superlative form on an adjective or adverb

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output: We need to choose the best sense for "compared" in the context. The context is about a study comparing the effects of Alimta in combination with cisplatin versus cisplatin alone. This is an examination of similarities or differences between two treatments. So it's sense 1: "examine and note the similarities or differences". The examples given: "John compared his haircut to his friend's" and "We compared notes" fit. Sense 2 is about being comparable (like "this car does not compare"), sense 3 is about likening or equating (like "we can compare the Han dynasty to the Romans"), sense 4 is grammatical. The context is clearly about comparing two treatments in a study, so sense 1 is appropriate. Thus answer: {"sense_index": 1}.{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: compare
Target surface form: compared
Context:
How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were <t>compared</t> with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past.

Candidate senses:
1. sense_key=compare%2:31:00:: | definition=examine and note the similarities or differences of | examples=John compared his haircut to his friend's; We compared notes after we had both seen the movie
2. sense_key=compare%2:42:00:: | definition=be comparable | examples=This car does not compare with our line of Mercedes
3. sense_key=compare%2:31:01:: | definition=consider or describe as similar, equal, or analogous | synonyms=liken, equate | examples=We can compare the Han dynasty to the Romans; You cannot equate success in financial matters with greed
4. sense_key=compare%2:32:00:: | definition=to form the comparative or superlative form on an adjective or adverb

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

[Assistant] We need to choose the best sense for "compared" in the context. The context is about a study comparing the effects of Alimta in combination with cisplatin versus cisplatin alone. This is an examination of similarities or differences between two treatments. So it's sense 1: "examine and note the similarities or differences". The examples given: "John compared his haircut to his friend's" and "We compared notes" fit. Sense 2 is about being comparable (like "this car does not compare"), sense 3 is about likening or equating (like "we can compare the Han dynasty to the Romans"), sense 4 is grammatical. The context is clearly about comparing two treatments in a study, so sense 1 is appropriate. Thus answer: {"sense_index": 1}.{"sense_index": 1}

[User] Your previous answer was invalid. Choose one candidate index between 1 and 4. Return only valid JSON exactly like {"sense_index": 1}.

reasoning_content: We need to correct the previous answer. The target word is "compared" in the context: "The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone." This is about examining similarities or differences, which is sense 1: "examine and note the similarities or differences of". So sense index is 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: treatment
Target surface form: treatment
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the <t>treatment</t> of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=treatment%1:04:00:: | definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) | synonyms=intervention
2. sense_key=treatment%1:04:01:: | definition=the management of someone or something | synonyms=handling | examples=the handling of prisoners; the treatment of water sewage
3. sense_key=treatment%1:07:00:: | definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture
4. sense_key=treatment%1:10:00:: | definition=an extended communication (often interactive) dealing with some particular topic | synonyms=discussion, discourse | examples=the book contains an excellent discussion of modal logic; his treatment of the race question is badly biased

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We are given a target word "treatment" in the context of medical treatment for cancer. The context clearly refers to medical care for diseases like malignant pleural mesothelioma and non-small cell lung cancer. The first sense (sense 1) is "care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)". This matches perfectly. The other senses are about management (sense 2), artistic manner (sense 3), and discussion (sense 4). None of those fit. So the answer is sense index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cell
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small <t>cell</t> lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content: We need to choose the best sense for "cell" in the context. The context talks about "non-small cell lung cancer" which is a type of lung cancer. The word "cell" here refers to a biological cell. The candidate senses: sense 2 is biology: basic structural and functional unit of all organisms. That matches. Other senses are about compartments, electric cells, political units, mobile phones, monk rooms, prison cells. Clearly sense 2 is correct. So answer {"sense_index": 2}.

provider: StreamLake