[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: form
Target surface form: form
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=form%1:10:00:: | definition=the phonological or orthographic sound or appearance of a word that can be used to describe or identify something | synonyms=word form, signifier, descriptor | examples=the inflected forms of a word can be represented by a stem and a list of inflections to be attached
2. sense_key=form%1:09:01:: | definition=a category of things distinguished by some common characteristic or quality | synonyms=kind, sort, variety | examples=sculpture is a form of art; what kinds of desserts are there?
3. sense_key=form%1:09:00:: | definition=a perceptual structure | synonyms=shape, pattern | examples=the composition presents problems for students of musical form; a visual pattern must include not only objects but the spaces between them
4. sense_key=form%1:07:01:: | definition=any spatial attributes (especially as defined by outline) | synonyms=shape, configuration, contour, conformation | examples=he could barely make out their shapes
5. sense_key=form%1:08:00:: | definition=alternative names for the body of a human being | synonyms=human body, physical body, material body, soma, build, figure | examples=Leonardo studied the human body; he has a strong physique
6. sense_key=form%1:03:00:: | definition=the spatial arrangement of something as distinct from its substance | synonyms=shape | examples=geometry is the mathematical science of shape
7. sense_key=form%1:07:00:: | definition=the visual appearance of something or someone | synonyms=shape, cast | examples=the delicate cast of his features
8. sense_key=form%1:10:01:: | definition=a printed document with spaces in which to write | examples=he filled out his tax form
9. sense_key=form%1:14:02:: | definition=(biology) a group of organisms within a species that differ in trivial ways from similar groups | synonyms=variant, strain, var. | examples=a new strain of microorganisms
10. sense_key=form%1:10:02:: | definition=an arrangement of the elements in a composition or discourse | examples=the essay was in the form of a dialogue; he first sketches the plot in outline form
11. sense_key=form%1:07:03:: | definition=a particular mode in which something is manifested | examples=his resentment took the form of extreme hostility
12. sense_key=form%1:26:00:: | definition=(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary | synonyms=phase | examples=the reaction occurs in the liquid phase of the system
13. sense_key=form%1:14:00:: | definition=a body of students who are taught together | synonyms=class, grade, course | examples=early morning classes are always sleepy
14. sense_key=form%1:07:02:: | definition=an ability to perform well | examples=he was at the top of his form; the team was off form last night
15. sense_key=form%1:06:00:: | definition=a life-size dummy used to display clothes | synonyms=mannequin, manikin, mannikin, manakin
16. sense_key=form%1:06:01:: | definition=a mold for setting concrete | examples=they built elaborate forms for pouring the foundation

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 11}
```

The context describes pemetrexed being "converted into an active form" that then performs a specific biological function. This is best captured by sense 11, which defines "form" as "a particular mode in which something is manifested." The drug takes on a particular active form/mode once converted in the body, similar to the example "his resentment took the form of extreme hostility." This sense captures how a substance or concept can manifest itself in a specific state or manner.

reasoning_content:
Let me analyze the context carefully. The sentence reads:

"In the body, pemetrexed is converted into an active <t>form</t> that blocks the activity of the enzymes that are involved in producing nucleotides..."

The context is about a drug (pemetrexed) being converted into an "active form" in the body. This is a biological/chemical context where "form" refers to a particular manifestation or state of a substance.

Let me go through the candidate senses:

1. sense_key=form%1:10:00:: - phonological or orthographic appearance (word form) - NOT relevant
2. sense_key=form%1:09:01:: - a category of things (kind, sort, variety) - Could fit, but not quite right
3. sense_key=form%1:09:00:: - a perceptual structure (shape, pattern) - Not quite right
4. sense_key=form%1:07:01:: - spatial attributes (shape, configuration) - Not right
5. sense_key=form%1:08:00:: - human body - Not relevant
6. sense_key=form%1:03:00:: - spatial arrangement as distinct from substance - Could fit
7. sense_key=form%1:07:00:: - visual appearance - Not right
8. sense_key=form%1:10:01:: - printed document - Not relevant
9. sense_key=form%1:14:02:: - biological variant/strain - Could fit
10. sense_key=form%1:10:02:: - arrangement of elements in composition - Not quite right
11. sense_key=form%1:07:03:: - particular mode in which something is manifested - This fits well!
12. sense_key=form%1:26:00:: - distinct state of matter (phase) - This could fit!
13. sense_key=form%1:14:00:: - body of students - Not relevant
14. sense_key=form%1:07:02:: - ability to perform well - Not relevant
15. sense_key=form%1:06:00:: - life-size dummy - Not relevant
16. sense_key=form%1:06:01:: - mold for concrete - Not relevant

The most promising interpretations are sense 11, describing how something manifests in a particular way (like "resentment took the form of hostility"), and sense 12, referring to distinct physical states or phases of matter. Both capture the idea of pemetrexed being converted into a specific chemical state that enables its biological function.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: block
Target surface form: blocks
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that <t>blocks</t> the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=block%2:35:00:: | definition=render unsuitable for passage | synonyms=barricade, blockade, stop, block off, block up, bar | examples=block the way; barricade the streets
2. sense_key=block%2:41:00:: | definition=hinder or prevent the progress or accomplishment of | synonyms=obstruct, blockade, hinder, stymie, stymy, embarrass | examples=His brother blocked him at every turn
3. sense_key=block%2:41:01:: | definition=stop from happening or developing | synonyms=stop, halt, kibosh | examples=Block his election; Halt the process
4. sense_key=block%2:32:00:: | definition=interfere with or prevent the reception of signals | synonyms=jam | examples=Jam the Voice of America; block the signals emitted by this station
5. sense_key=block%2:41:03:: | definition=run on a block system | examples=block trains
6. sense_key=block%2:39:05:: | definition=interrupt the normal function of by means of anesthesia | examples=block a nerve; block a muscle
7. sense_key=block%2:39:00:: | definition=shut out from view or get in the way so as to hide from sight | synonyms=obstruct | examples=The thick curtain blocked the action on the stage; The trees obstruct my view of the mountains
8. sense_key=block%2:35:03:: | definition=stamp or emboss a title or design on a book with a block | examples=block the book cover
9. sense_key=block%2:35:02:: | definition=obstruct | synonyms=stuff, lug, choke up | examples=My nose is all stuffed; Her arteries are blocked
10. sense_key=block%2:35:12:: | definition=block passage through | synonyms=obstruct, obturate, impede, occlude, jam, close up | examples=obstruct the path
11. sense_key=block%2:35:06:: | definition=support, secure, or raise with a block | examples=block a plate for printing; block the wheels of a car
12. sense_key=block%2:33:00:: | definition=impede the movement of (an opponent or a ball) | synonyms=parry, deflect | examples=block an attack
13. sense_key=block%2:31:00:: | definition=be unable to remember | synonyms=forget, blank out, draw a blank | examples=I'm drawing a blank; You are blocking the name of your first wife!
14. sense_key=block%2:30:01:: | definition=shape by using a block | examples=Block a hat; block a garment
15. sense_key=block%2:30:00:: | definition=shape into a block or blocks | examples=block the graphs so one can see the results clearly
16. sense_key=block%2:30:02:: | definition=prohibit the conversion or use of (assets) | synonyms=freeze, immobilize, immobilise | examples=Blocked funds; Freeze the assets of this hostile government

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

finish_reason: stop

role: assistant

reasoning_content:
Let me analyze the context for the word "blocks" (in the form "blocks the activity").

The sentence is: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides..."

This is describing how a medicine works - it prevents the enzymes from functioning normally. The active substance "blocks" the activity of enzymes.

Let me look at the candidate senses:

1. render unsuitable for passage - This is about physical blocking, not applicable.
2. hinder or prevent the progress or accomplishment of - This could work. It's about preventing something from happening.
3. stop from happening or developing - This fits well. The medicine stops the enzyme activity.
4. interfere with or prevent the reception of signals - Not about signals.
5. run on a block system - Not applicable.
6. interrupt the normal function of by means of anesthesia - This is specific to anesthesia, not general.
7. shut out from view - Not applicable.
8. stamp or emboss a title - Not applicable.
9. obstruct - Could work. The medicine obstructs enzyme function.
10. block passage through - Could work for blocking enzymatic activity.
11. support, secure, or raise with a block - Not applicable.
12. impede the movement of - About physical blocking.
13. be unable to remember - Not applicable.
14. shape by using a block - Not applicable.
15. shape into a block or blocks - Not applicable.
16. prohibit the conversion or use of - Not applicable.

The key meaning here is that the medicine prevents or inhibits the enzyme activity. Looking at the senses:

Sense 2: "hinder or prevent the progress or accomplishment of" - This is general and fits inhibiting enzyme function.
Sense 3 captures the idea of stopping enzyme activity from occurring. In medical terminology, "block" often refers to interrupting normal function—like blocking a nerve or muscle—which aligns with how the drug prevents enzymatic processes. The most fitting sense appears to be one that emphasizes inhibition or cessation of function rather than physical obstruction.

type: thinking

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: involved
Target surface form: involved
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=involved%3:00:00:: | definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved; the problems involved
2. sense_key=involved%5:00:00:encumbered:00 | definition=entangled or hindered as if e.g. in mire | synonyms=mired | examples=the difficulties in which the question is involved; brilliant leadership mired in details and confusion
3. sense_key=involved%5:00:00:attached:01 | definition=emotionally involved
4. sense_key=involved%5:00:00:complex:00 | definition=highly complex or intricate and occasionally devious; ; ; ; ; ; ; ; - Sir Walter Scott | synonyms=Byzantine, convoluted, knotty, tangled, tortuous | examples=the Byzantine tax structure; Byzantine methods for holding on to his chairmanship
5. sense_key=involved%5:00:00:enclosed:00 | definition=enveloped | examples=a castle involved in mist; the difficulties in which the question is involved

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The context describes enzymes that are "involved in producing nucleotides," which clearly means enzymes that participate in or are connected with the process of nucleotide production. This matches sense 1's definition of "connected by participation or association or use," as shown in the example "the problems involved" which similarly indicates participation or connection.

reasoning_content:
Let me analyze the context to determine the best sense of "involved" in this sentence:

"In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are <t>involved</t> in producing nucleotides..."

The phrase "enzymes that are involved in producing nucleotides" means enzymes that participate in or are connected to the process of producing nucleotides.

Let me examine each candidate sense:

1. sense_key=involved%3:00:00:: | definition=connected by participation or association or use | examples=we accomplished nothing, simply because of the large number of people involved; the problems involved
   - This definition fits perfectly. "Involved in" means "participating in" or "connected with" the process of producing nucleotides.

2. sense_key=involved%5:00:00:encumbered:00 | definition=entangled or hindered as if e.g. in mire
   - This doesn't fit. The enzymes aren't hindered or trapped.

3. sense_key=involved%5:00:00:attached:01 | definition=emotionally involved
   - This doesn't fit. There's no emotional context here.

4. sense_key=involved%5:00:00:complex:00 | definition=highly complex or intricate and occasionally devious
   - This doesn't fit. We're not describing the enzymes as complex.

5. sense_key=involved%5:00:00:enclosed:00 | definition=enveloped
   - This doesn't fit. The enzymes aren't being enveloped.

The correct sense is sense 1, which refers to being connected through participation or association. The enzymes are "involved in" producing nucleotides means they participate in or are engaged in that process.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: produce
Target surface form: producing
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in <t>producing</t> nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=produce%2:36:02:: | definition=bring forth or yield | synonyms=bring forth | examples=The tree would not produce fruit
2. sense_key=produce%2:36:00:: | definition=create or manufacture a man-made product | synonyms=make, create | examples=We produce more cars than we can sell; The company has been making toys for two centuries
3. sense_key=produce%2:36:03:: | definition=cause to happen, occur or exist | synonyms=bring about, give rise | examples=This procedure produces a curious effect; The new law gave rise to many complaints
4. sense_key=produce%2:39:01:: | definition=bring out for display | synonyms=bring forth | examples=The proud father produced many pictures of his baby; The accused brought forth a letter in court that he claims exonerates him
5. sense_key=produce%2:36:05:: | definition=cultivate by growing, often involving improvements by means of agricultural techniques | synonyms=grow, raise, farm | examples=The Bordeaux region produces great red wines; They produce good ham in Parma
6. sense_key=produce%2:39:00:: | definition=bring onto the market or release | synonyms=bring on, bring out | examples=produce a movie; bring out a book
7. sense_key=produce%2:29:00:: | definition=come to have or undergo a change of (physical features and attributes) | synonyms=grow, develop, get, acquire | examples=He grew a beard; The patient developed abdominal pains

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 3}
```

The context describes how pemetrexed blocks enzymes that are "involved in producing nucleotides." In this biochemical context, "producing" means the enzymes cause or bring about the synthesis of nucleotides—they create these molecular building blocks through their enzymatic activity. This matches sense 3 ("cause to happen, occur or exist"), which captures the idea of enzymatic action causing the generation of nucleotides in the body.

reasoning_content:
Let me analyze the context carefully. The target word is "producing" in this sentence:

"In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

Here, "producing" refers to the creation/generation of nucleotides. Let me examine each candidate sense:

1. "bring forth or yield" - This is more about natural production (like fruit from a tree)
2. "create or manufacture a man-made product" - This is about making products through manufacturing
3. "cause to happen, occur or exist" - This means to cause something to come into being or to bring about
4. "bring out for display" - This is about showing/displaying something
5. "cultivate by growing, often involving improvements by means of agricultural techniques" - This is about agriculture/growing
6. "bring onto the market or release" - This is about releasing products to market
7. "come to have or undergo a change of (physical features and attributes)" - This is about developing/growing physical features

In the medical context, "producing nucleotides" means the enzymes are involved in "causing" or "bringing about" the creation/synthesis of nucleotides. The enzymes synthesize/create nucleotides in a chemical/biological process.

Sense 3 ("cause to happen, occur or exist") seems most appropriate here. The enzymes are involved in causing nucleotides to come into existence through the biological process.

Sense 1 could also work, but it's more about natural yield (like fruit).
Sense 2 is about manufacturing, which could fit.
Sense 3 is about causing something to happen or exist, which fits the biological synthesis context.

I think sense 3 is the best fit because it describes the causal process by which nucleotides come into being through enzymatic activity, without being limited to natural production or manufacturing.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: building_block
Target surface form: building blocks
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the <t>building blocks</t> of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=building_block%1:17:00:: | definition=a single undivided natural thing occurring in the composition of something else | synonyms=unit | examples=units of nucleic acids
2. sense_key=building_block%1:06:00:: | definition=a block of material used in construction work

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The context clearly indicates that nucleotides are the fundamental components or units that compose DNA and RNA. This matches sense 1, which defines "building blocks" as "a single undivided natural thing occurring in the composition of something else" with the example "units of nucleic acids." The literal, physical sense (sense 2) about construction materials is inappropriate in this molecular biology context.

reasoning_content:
Let me analyze the context and the two candidate senses for "building blocks".

Context: "pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

The sentence is explaining that nucleotides are the "building blocks" of DNA and RNA. DNA and RNA are made up of nucleotides as their fundamental components.

Candidate senses:
1. sense_key=building_block%1:17:00:: | definition=a single undivided natural thing occurring in the composition of something else | synonyms=unit | examples=units of nucleic acids
   - This refers to something that is a component or unit used to construct something larger
   - The example "units of nucleic acids" is directly relevant
   - This is the metaphorical sense where "building blocks" means fundamental components

2. sense_key=building_block%1:06:00:: | definition=a block of material used in construction work
   - This is the literal, physical sense referring to actual construction materials
   - This is not appropriate in the context of molecular biology

In the context, nucleotides are described as the "building blocks" of DNA and RNA. This is clearly using the metaphorical sense where building blocks means fundamental components or units that compose something larger - in this case, DNA and RNA molecules.

Sense 1 is the correct choice because:
- It captures the meaning of fundamental components
- The example mentions "units of nucleic acids" which is exactly what we're discussing
- It matches the metaphorical use in molecular biology context

So the answer should be sense_index: 1


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: genetic
Target surface form: genetic
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the <t>genetic</t> material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=genetic%5:00:00:inheritable:00 | definition=occurring among members of a family usually by heredity | synonyms=familial, hereditary, inherited, transmitted, transmissible | examples=an inherited disease; familial traits
2. sense_key=genetic%3:01:02:: | definition=of or relating to or produced by or being a gene | synonyms=genic, genetical | examples=genic combinations; genetic code
3. sense_key=genetic%3:01:01:: | definition=pertaining to or referring to origin | examples=genetic history reconstructs the origins of a literary work
4. sense_key=genetic%3:01:00:: | definition=of or relating to the science of genetics | synonyms=genetical | examples=genetic research

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

The context describes DNA and RNA as "the genetic material of cells." This is using "genetic" in the sense of "of or relating to or produced by or being a gene" (sense 2). DNA and RNA are the physical basis of genes and carry genetic information. This is distinct from sense 1 (hereditary traits in families), sense 3 (historical origins), and sense 4 (the field of genetics as a science).

reasoning_content:
Let me analyze the context to determine which sense of "genetic" is being used.

The context is: "...blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

Here, "genetic material" is referring to DNA and RNA, which are the molecules that carry genetic information in cells. The phrase "genetic material" is a standard biological term that refers to the hereditary material in organisms.

Let me evaluate each sense:

1. sense_key=genetic%5:00:00:inheritable:00 - "occurring among members of a family usually by heredity" - This relates to hereditary traits passed through families. This doesn't quite fit because "genetic material" isn't necessarily about family inheritance or heredity in that sense.

2. sense_key=genetic%3:01:02:: - "of or relating to or produced by or being a gene" - This refers to genes and genetic code. DNA and RNA are indeed related to genes, as they are the physical basis of genes. This could fit.

3. sense_key=genetic%3:01:01:: - "pertaining to or referring to origin" - This is about origins. While DNA/RNA do have to do with the origin of traits, this sense seems more about historical or literary origins.

4. sense_key=genetic%3:01:00:: - "of or relating to the science of genetics" - This refers to the field of genetics as a science. While DNA and RNA are studied in genetics, this is about the science itself, not the material.

The phrase "genetic material" is a standard biological term that specifically refers to DNA and RNA as the physical carriers of hereditary information. This is best captured by sense 2, which refers to genes and what's produced by or relates to genes. DNA and RNA are the physical manifestations of genetic information and genes.

Actually, thinking more carefully: "genetic material" is the standard term in biology for DNA/RNA.

Sense 2 is the right fit—it directly addresses the relationship between genetic material and genes, since DNA and RNA are the actual substance that comprises genes and encodes hereditary information.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: material
Target surface form: material
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic <t>material</t> of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=material%1:27:00:: | definition=the tangible substance that goes into the makeup of a physical object | synonyms=stuff | examples=coal is a hard black material; wheat is the stuff they use to make bread
2. sense_key=material%1:10:00:: | definition=information (data or ideas or observations) that can be used or reworked into a finished form | examples=the archives provided rich material for a definitive biography
3. sense_key=material%1:06:00:: | definition=artifact made by weaving or felting or knitting or crocheting natural or synthetic fibers | synonyms=fabric, cloth, textile | examples=the fabric in the curtains was light and semitransparent; woven cloth originated in Mesopotamia around 5000 BC
4. sense_key=material%1:06:01:: | definition=things needed for doing or making something | examples=writing materials; useful teaching materials
5. sense_key=material%1:18:00:: | definition=a person judged suitable for admission or employment | examples=he was university material; she was vice-presidential material

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
{"sense_index": 1}

The phrase "the genetic material of cells" refers to DNA and RNA as the tangible, physical substances that compose the genetic makeup of cells. This best matches sense 1, which defines material as "the tangible substance that goes into the makeup of a physical object." While DNA and RNA carry genetic information, the context emphasizes them as the physical substance itself ("the building blocks of DNA and RNA"), not as abstract information content.

reasoning_content:
Let me analyze the context carefully. The sentence is:

"pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic <t>material</t> of cells)"

So here "material" refers to the genetic material of cells. Let me consider each sense:

1. sense_key=material%1:27:00:: - "the tangible substance that goes into the makeup of a physical object" - This refers to physical stuff/substance. DNA and RNA are indeed tangible substances that make up cells.

2. sense_key=material%1:10:00:: - "information (data or ideas or observations) that can be used or reworked into a finished form" - This is about information/data that can be processed.

3. sense_key=material%1:06:00:: - "artifact made by weaving or felting..." - This is about fabric/cloth, clearly not applicable.

4. sense_key=material%1:06:01:: - "things needed for doing or making something" - This is about supplies/materials needed for a task.

5. sense_key=material%1:18:00:: - "a person judged suitable for admission or employment" - Not applicable.

In the context "the genetic material of cells," we're talking about DNA and RNA as the substance that makes up the genetic information of cells. This is most clearly sense 1 - the tangible substance that goes into the makeup of a physical object. DNA and RNA are tangible substances.

Actually, wait. Could it be sense 2? "Information (data or ideas or observations)..." DNA and RNA do carry genetic information. But the definition emphasizes "information... that can be used or reworked" which is more about data/information content rather than the physical substance.

Given the context emphasizes "the genetic material of cells," and DNA/RNA are physical molecules (tangible substances), I believe sense 1 (material%1:27:00::) is the best fit.

DNA and RNA function as the physical molecules that form the genetic composition of cells, making sense 1 the most appropriate interpretation.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cells
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of <t>cells</t>). How has Alimta been studied?

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

The context clearly refers to biological cells containing genetic material (DNA and RNA). The passage discusses how pemetrexed works by interfering with nucleotide production, which are the building blocks of genetic material within cells. This is explicitly referring to cells as the basic structural and functional units of living organisms, not compartments in a honeycomb, electrical devices, prison cells, or any other sense.

reasoning_content:
Let me analyze the context to find the best sense for "cells" in this passage.

The context is about Alimta, a medicine, and how it works. The specific sentence is: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

The passage is clearly discussing biology and medicine. It mentions:
- DNA and RNA (genetic material)
- Nucleotides (building blocks of DNA and RNA)
- The fact that cells contain genetic material

This is clearly referring to the biological definition of cells - the basic structural and functional units of living organisms that contain genetic material (DNA and RNA).

Let me check the candidate senses:

1. sense_key=cell%1:06:03:: - "any small compartment" (honeycomb cells) - This is too general and doesn't fit the biological context
2. sense_key=cell%1:03:00:: - "(biology) the basic structural and functional unit of all organisms" - This perfectly matches! This is about biological cells that contain genetic material
3. sense_key=cell%1:06:00:: - "a device that delivers an electric current" - Not relevant
4. sense_key=cell%1:14:00:: - "a small unit serving as part of a larger political movement" - Not relevant
5. sense_key=cell%1:06:04:: - "a hand-held mobile radiotelephone" - Not relevant
6. sense_key=cell%1:06:02:: - "small room in a monastery" - Not relevant
7. sense_key=cell%1:06:01:: - "a room where a prisoner is kept" - Not relevant

The answer is clearly sense 2 (sense_key=cell%1:03:00::), which is the biological definition of cells as the basic structural and functional units of organisms.

The question asks me to return the sense_index, which would be 2 (since it's the second option in the list).


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: study
Target surface form: studied
Context:
Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been <t>studied</t>? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before.

Candidate senses:
1. sense_key=study%2:31:02:: | definition=consider in detail and subject to an analysis in order to discover essential features or meaning | synonyms=analyze, analyse, examine, canvass, canvas | examples=analyze a sonnet by Shakespeare; analyze the evidence in a criminal trial
2. sense_key=study%2:31:03:: | definition=be a student; follow a course of study; be enrolled at an institute of learning
3. sense_key=study%2:39:00:: | definition=give careful consideration to | synonyms=consider | examples=consider the possibility of moving
4. sense_key=study%2:31:00:: | definition=be a student of a certain subject | synonyms=learn, read, take | examples=She is reading for the bar exam
5. sense_key=study%2:31:01:: | definition=learn by reading books | synonyms=hit the books | examples=He is studying geology in his room; I have an exam next week; I must hit the books now
6. sense_key=study%2:31:04:: | definition=think intently and at length, as for spiritual purposes | synonyms=meditate, contemplate | examples=He is meditating in his study

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The word "studied" in this medical context means that Alimta has been examined, analyzed, and investigated in clinical research (in a formal study with 456 patients). This corresponds to sense 1, which defines "study" as "consider in detail and subject to an analysis in order to discover essential features or meaning" with synonyms like "analyze" and "examine." The passive construction "has been studied" refers to the drug being subjected to detailed analysis and investigation in a clinical trial, which aligns with the analytical/investigative sense of the verb.

reasoning_content:
Let me analyze the context for the word "studied" in this medical text.

The sentence is: "How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before."

In this context, "studied" is being used in a passive voice construction, referring to clinical research/testing of a drug. It means that Alimta has been tested/examined/investigated in a clinical trial.

Let me examine each sense:

1. sense_key=study%2:31:02:: - "consider in detail and subject to an analysis in order to discover essential features or meaning" - This is about analyzing something in detail, like analyzing evidence or a work of literature. This could fit.

2. sense_key=study%2:31:03:: - "be a student; follow a course of study; be enrolled at an institute of learning" - This doesn't fit. It's about being a student.

3. sense_key=study%2:39:00:: - "give careful consideration to" - This is more general consideration, similar to sense 1.

4. sense_key=study%2:31:00:: - "be a student of a certain subject" - About studying a subject, doesn't fit.

5. sense_key=study%2:31:01:: - "learn by reading books" - About learning from books, doesn't fit.

6. sense_key=study%2:31:04:: - "think intently and at length, as for spiritual purposes" - About meditation, doesn't fit.

The context is clearly about conducting research/clinical trials. The drug has been "studied" meaning it has been investigated/examined/analyzed in a clinical research setting.

Sense 1 (analyze, examine) seems most appropriate here. "Alimta has been studied in one main study" means it has been examined/investigated/analyzed in a clinical trial.
The most fitting sense is index 1, which captures the meaning of examining and analyzing the drug through clinical investigation.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: treatment
Target surface form: treatment
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the <t>treatment</t> of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=treatment%1:04:00:: | definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) | synonyms=intervention
2. sense_key=treatment%1:04:01:: | definition=the management of someone or something | synonyms=handling | examples=the handling of prisoners; the treatment of water sewage
3. sense_key=treatment%1:07:00:: | definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture
4. sense_key=treatment%1:10:00:: | definition=an extended communication (often interactive) dealing with some particular topic | synonyms=discussion, discourse | examples=the book contains an excellent discussion of modal logic; his treatment of the race question is badly biased

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

content:
```json
{"sense_index": 1}
```

reasoning_content:
The word "treatment" appears in the context of a medical text about Alimta, a cancer medicine. The sentence states: "For the treatment of malignant pleural mesothelioma, Alimta has been studied..."

Let me analyze the candidate senses:

1. sense_key=treatment%1:04:00:: - care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) - synonyms: intervention
   - This is clearly about medical treatment/care
   - This fits perfectly with the context of treating cancer (malignant pleural mesothelioma)

2. sense_key=treatment%1:04:01:: - the management of someone or something - synonyms: handling - examples: the handling of prisoners; the treatment of water sewage
   - This is about management/handling in a more general sense
   - Not specifically medical

3. sense_key=treatment%1:07:00:: - a manner of dealing with something artistically
   - This is about artistic treatment
   - Not relevant here

4. sense_key=treatment%1:10:00:: - an extended communication (often interactive) dealing with some particular topic
   - This is about a discussion/discourse
   - Not relevant here

The context is clearly medical - discussing Alimta's use in treating malignant pleural mesothelioma. Sense 1 is the perfect match because it specifically mentions "medical procedures or applications that are intended to relieve illness or injury" and has "intervention" as a synonym. The synonym "intervention" also fits well in medical contexts.

The answer should be sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: study
Target surface form: studied
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been <t>studied</t> in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=study%2:31:02:: | definition=consider in detail and subject to an analysis in order to discover essential features or meaning | synonyms=analyze, analyse, examine, canvass, canvas | examples=analyze a sonnet by Shakespeare; analyze the evidence in a criminal trial
2. sense_key=study%2:31:03:: | definition=be a student; follow a course of study; be enrolled at an institute of learning
3. sense_key=study%2:39:00:: | definition=give careful consideration to | synonyms=consider | examples=consider the possibility of moving
4. sense_key=study%2:31:00:: | definition=be a student of a certain subject | synonyms=learn, read, take | examples=She is reading for the bar exam
5. sense_key=study%2:31:01:: | definition=learn by reading books | synonyms=hit the books | examples=He is studying geology in his room; I have an exam next week; I must hit the books now
6. sense_key=study%2:31:04:: | definition=think intently and at length, as for spiritual purposes | synonyms=meditate, contemplate | examples=He is meditating in his study

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The context shows that Alimta has been examined and analyzed in detail through a clinical study involving 456 patients. The word "studied" here means to subject something to careful analysis and investigation to discover its features and effects (how the drug works, its efficacy). This matches sense 1, which defines "study" as "consider in detail and subject to an analysis in order to discover essential features or meaning" with synonyms including "analyze" and "examine."

reasoning_content:
Let me analyze the context of the word "studied" in the sentence:

"For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients..."

Here, "studied" is in passive voice and refers to how a medication (Alimta) has been researched or tested/examined in a clinical context. The sentence is saying that Alimta has been subjected to examination/research in a clinical study.

Let me look at each sense:

1. "consider in detail and subject to an analysis in order to discover essential features or meaning" - This fits well. The medication has been analyzed/examined in detail through a study. Synonyms include analyze, examine, which match the context.

2. "be a student; follow a course of study; be enrolled at an institute of learning" - This doesn't fit. The context is about a medication being tested, not about someone being a student.

3. "give careful consideration to" - This could fit somewhat, but it's more general.

4. "be a student of a certain subject" - This doesn't fit. Not about someone studying a subject.

5. "learn by reading books" - Doesn't fit the context at all.

6. "think intently and at length, as for spiritual purposes" - Doesn't fit.

The best fit is sense 1: "consider in detail and subject to an analysis in order to discover essential features or meaning". The medication has been analyzed/examined in detail through a clinical study to determine its effectiveness.

This makes sense with the context: the drug has been investigated/analyzed through a clinical trial to understand how it works and its effects.

So the answer should be sense index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: main
Target surface form: main
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one <t>main</t> study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=main%5:00:00:important:00 | definition=most important element | synonyms=chief, primary, principal, master | examples=the chief aim of living; the main doors were of solid glass
2. sense_key=main%3:00:02:: | definition=(of a clause) capable of standing syntactically alone as a complete sentence | synonyms=independent | examples=the main (or independent) clause in a complex sentence has at least a subject and a verb
3. sense_key=main%5:00:00:intense:00 | definition=of force; of the greatest possible intensity | examples=by main strength

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

content:
```json
{"sense_index": 1}
```

reasoning_content:
Let me analyze the context to determine which sense of "main" is being used.

The context is: "For the treatment of malignant pleural mesothelioma, Alimta has been studied in one <t>main</t> study in 456 patients..."

Here, "main" is describing the study. The sentence is saying that there was one principal/chief/primary study. In this context, "main" is acting as an adjective meaning "most important" or "principal."

Let me examine the three candidate senses:

1. sense_key=main%5:00:00:important:00 | definition=most important element | synonyms=chief, primary, principal, master | examples=the chief aim of living; the main doors were of solid glass

2. sense_key=main%3:00:02:: | definition=(of a clause) capable of standing syntactically alone as a complete sentence | synonyms=independent | examples=the main (or independent) clause in a complex sentence has at least a subject and a verb

3. sense_key=main%5:00:00:intense:00 | definition=of force; of the greatest possible intensity | examples=by main strength

In the sentence, "main" describes "study" - it means the primary or most important study. This clearly matches sense 1, which defines it as "most important element" with synonyms "chief, primary, principal." The examples even include "the main doors" which shows similar usage to our context.

Sense 2 is about grammar - the main clause in a complex sentence. This doesn't apply here.

Sense 3 is about intense force, as in "by main strength." This also doesn't apply.

The best answer is sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: study
Target surface form: study
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main <t>study</t> in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=study%1:04:00:: | definition=a detailed critical inspection | synonyms=survey
2. sense_key=study%1:09:03:: | definition=applying the mind to learning and understanding a subject (especially by reading) | synonyms=work | examples=mastering a second language requires a lot of work; no schools offer graduate study in interior design
3. sense_key=study%1:10:00:: | definition=a written document describing the findings of some individual or group | synonyms=report, written report | examples=this accords with the recent study by Hill and Dale
4. sense_key=study%1:09:04:: | definition=a state of deep mental absorption | examples=she is in a deep study
5. sense_key=study%1:06:00:: | definition=a room used for reading and writing and studying | examples=he knocked lightly on the closed door of the study
6. sense_key=study%1:09:02:: | definition=a branch of knowledge | synonyms=discipline, subject, subject area, subject field, field, field of study | examples=in what discipline is his doctorate?; teachers should be well trained in their subject
7. sense_key=study%1:06:01:: | definition=preliminary drawing for later elaboration | synonyms=sketch | examples=he made several studies before starting to paint
8. sense_key=study%1:09:01:: | definition=attentive consideration and meditation | synonyms=cogitation | examples=after much cogitation he rejected the offer
9. sense_key=study%1:18:00:: | definition=someone who memorizes quickly and easily (as the lines for a part in a play) | examples=he is a quick study
10. sense_key=study%1:10:01:: | definition=a composition intended to develop one aspect of the performer's technique | examples=a study in spiccato bowing

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 3}
```

content:
```json
{"sense_index": 3}
```

reasoning_content:
Let me analyze the context to find the best sense for "study" in this sentence:

"For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before."

The sentence is talking about a clinical trial/research where a medicine (Alimta) was tested in 456 patients to see if it works. The context shows "Alimta has been studied in one main study" - this is referring to a research investigation or clinical trial.

Let me look at the candidate senses:

1. sense_key=study%1:04:00:: | definition=a detailed critical inspection | synonyms=survey
   - This could work - a clinical trial is a detailed critical inspection of a drug's efficacy

2. sense_key=study%1:09:03:: | definition=applying the mind to learning and understanding a subject (especially by reading)
   - Not appropriate here - it's not about learning by reading

3. sense_key=study%1:10:00:: | definition=a written document describing the findings of some individual or group | synonyms=report, written report | examples=this accords with the recent study by Hill and Dale
   - This is very fitting. A clinical study is a written document/report describing findings of a research investigation

4. sense_key=study%1:09:04:: | definition=a state of deep mental absorption
   - Not appropriate

5. sense_key=study%1:06:00:: | definition=a room used for reading and writing and studying
   - Not appropriate

6. sense_key=study%1:09:02:: | definition=a branch of knowledge
   - Not appropriate

7. sense_key=study%1:06:01:: | definition=preliminary drawing for later elaboration
   - Not appropriate

8. sense_key=study%1:09:01:: | definition=attentive consideration and meditation
   - Not appropriate

9. sense_key=study%1:18:00:: | definition=someone who memorizes quickly and easily
   - Not appropriate

10. sense_key=study%1:10:01:: | definition=a composition intended to develop one aspect of the performer's technique
   - Not appropriate

The best match is sense 3 (study%1:10:00::), which refers to "a written document describing the findings of some individual or group." In medical contexts, a "study" typically refers to a research study or clinical trial, which is indeed a formal investigation that produces findings documented in a report. The answer should be 3.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 <t>patients</t> who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The context clearly refers to actual people receiving medical care in a clinical trial for mesothelioma treatment. The phrase "456 patients who had not received chemotherapy for their disease before" describes real individuals requiring medical treatment, which matches sense 1: "a person who requires medical care." Sense 2 refers to a grammatical/semantic role, not the concrete meaning intended here.

reasoning_content:
Let me analyze the context to determine which sense of "patients" is being used.

The sentence is: "For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before."

Looking at the two candidate senses:

1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly

2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

In this context, "patients" refers to actual people who require medical care and are being studied in a clinical trial for treatment of mesothelioma. These are real persons who are receiving or have received medical treatment.

Sense 1 is about "a person who requires medical care" - this fits perfectly with the context. The patients are people requiring medical care for mesothelioma, and they're being studied in a clinical trial.

Sense 2 is about a semantic/grammatical role - "the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause." This is a linguistic/grammatical sense, not referring to actual people receiving medical care.

The context clearly uses "patients" to refer to actual people receiving medical treatment, so sense 1 is the correct choice.

Sense 1 is the first sense listed, so the answer should be:
{"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: before
Target surface form: before
Context:
For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease <t>before</t>. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone.

Candidate senses:
1. sense_key=before%4:02:03:: | definition=earlier in time; previously | synonyms=earlier | examples=I had known her before; as I said before
2. sense_key=before%4:02:01:: | definition=at or in the front | synonyms=ahead, in front | examples=I see the lights of a town ahead; the road ahead is foggy

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The word "before" in this context refers to a time earlier than when the study was conducted. The sentence states that patients "had not received chemotherapy for their disease before," meaning they had not received it previously. This matches sense 1 ("earlier in time; previously") rather than sense 2 ("at or in the front"), which pertains to spatial positioning.

reasoning_content:
Let me analyze the context of the word "before" in the sentence:

"For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before."

The word "before" here is referring to a time point that is earlier than the current time or the time being discussed. It means "previously" or "earlier in time" - the patients had not received chemotherapy prior to the study.

Let me look at the two candidate senses:

1. "earlier in time; previously" with examples like "I had known her before; as I said before" - This clearly fits the context. The patients had not received chemotherapy before (previously).

2. "at or in the front" with synonyms "ahead, in front" - This doesn't fit the context at all. The sentence is not talking about spatial positioning or direction.

The correct sense is clearly sense 1 - "before" is being used in its temporal meaning to indicate something that happened previously.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: effect
Target surface form: effects
Context:
How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The <t>effects</t> of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past.

Candidate senses:
1. sense_key=effect%1:19:00:: | definition=a phenomenon that follows and is caused by some previous phenomenon | synonyms=consequence, outcome, result, event, issue, upshot | examples=the magnetic effect was greater when the rod was lengthwise; his decision had depressing consequences for business
2. sense_key=effect%1:07:00:: | definition=an outward appearance | synonyms=impression | examples=he made a good impression; I wanted to create an impression of success
3. sense_key=effect%1:09:00:: | definition=an impression (especially one that is artificial or contrived) | examples=he just did it for effect
4. sense_key=effect%1:10:00:: | definition=the central meaning or theme of a speech or literary work | synonyms=essence, burden, core, gist
5. sense_key=effect%1:07:01:: | definition=(of a law) having legal validity | synonyms=force | examples=the law is still in effect
6. sense_key=effect%1:26:00:: | definition=a symptom caused by an illness or a drug | examples=the effects of sleep loss; the effect of the anesthetic

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
Let me analyze the context to determine which sense of "effects" is being used.

The context is discussing a medical study about Alimta (pemetrexed), a cancer medicine. The specific passage is:

"The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel..."

Here, "effects" refers to the results or outcomes of using the medicine - specifically, how well the treatment works compared to other treatments. This is clearly about the consequences or outcomes of using Alimta.

Let me evaluate the candidate senses:

1. **sense_key=effect%1:19:00::** - "a phenomenon that follows and is caused by some previous phenomenon" with synonyms: consequence, outcome, result, event, issue, upshot. This fits perfectly - the effects of Alimta refer to the outcomes/results of using this medicine.

2. **sense_key=effect%1:07:00::** - "an outward appearance" - doesn't fit the context.

3. **sense_key=effect%1:09:00::** - "an impression (especially one that is artificial or contrived)" - doesn't fit.

4. **sense_key=effect%1:10:00::** - "the central meaning or theme of a speech or literary work" - doesn't fit.

5. **sense_key=effect%1:07:01::** - "(of a law) having legal validity" - doesn't fit.

6. **sense_key=effect%1:26:00::** - "a symptom caused by an illness or a drug" - this could also fit in a medical context, as effects of drugs are symptoms. However, in this context, we're talking about the therapeutic effects or outcomes of the treatment, not necessarily adverse symptoms.
Sense 1 is the best fit since the passage emphasizes comparing treatment results across different clinical approaches rather than cataloging drug-induced symptoms. The study's focus on comparative outcomes of Alimta versus alternative therapies points to the meaning of effects as results or consequences.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: compare
Target surface form: compared
Context:
How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were <t>compared</t> with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past.

Candidate senses:
1. sense_key=compare%2:31:00:: | definition=examine and note the similarities or differences of | examples=John compared his haircut to his friend's; We compared notes after we had both seen the movie
2. sense_key=compare%2:42:00:: | definition=be comparable | examples=This car does not compare with our line of Mercedes
3. sense_key=compare%2:31:01:: | definition=consider or describe as similar, equal, or analogous | synonyms=liken, equate | examples=We can compare the Han dynasty to the Romans; You cannot equate success in financial matters with greed
4. sense_key=compare%2:32:00:: | definition=to form the comparative or superlative form on an adjective or adverb

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The context describes a scientific study where researchers are examining and noting the differences between the effects of Alimta combined with cisplatin versus cisplatin alone. This matches sense 1 ("examine and note the similarities or differences of"), which is the standard usage in medical research contexts when evaluating and contrasting treatment outcomes.

reasoning_content:
Let me analyze the context and the target word "compared" to determine the best sense.

In the context, the sentence is: "The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone."

This is in a medical/scientific context where they are examining and noting the similarities or differences between the effects of two treatments: Alimta+cisplatin versus cisplatin alone.

Let me examine each sense:

1. "examine and note the similarities or differences of" - This is exactly what's happening in the context. They are comparing the effects of two different treatments to see how they differ.

2. "be comparable" - This doesn't fit. The sentence structure is passive voice "were compared with" not a statement about whether things are comparable.

3. "consider or describe as similar, equal, or analogous" - This could work, but the context suggests they're examining differences, not necessarily describing them as similar or equal.

4. "to form the comparative or superlative form on an adjective or adverb" - This is about grammar and doesn't apply here.

The most appropriate sense is #1 because:
- It matches the scientific context where they're examining and noting similarities/differences between two treatments
- The example "John compared his haircut to his friend's" is similar in structure to "compared [effects] with [other effects]"
- This is the standard usage in scientific studies where you compare different treatments to evaluate their relative effectiveness

The answer is sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: treatment
Target surface form: treatment
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the <t>treatment</t> of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=treatment%1:04:00:: | definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) | synonyms=intervention
2. sense_key=treatment%1:04:01:: | definition=the management of someone or something | synonyms=handling | examples=the handling of prisoners; the treatment of water sewage
3. sense_key=treatment%1:07:00:: | definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture
4. sense_key=treatment%1:10:00:: | definition=an extended communication (often interactive) dealing with some particular topic | synonyms=discussion, discourse | examples=the book contains an excellent discussion of modal logic; his treatment of the race question is badly biased

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The context is clearly about medical intervention for cancer. The phrase "treatment of non-small cell lung cancer" refers to medical procedures and applications (specifically pharmaceutical interventions with Alimta) intended to relieve illness. Sense 1 explicitly defines treatment as "care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)" with the synonym "intervention," which perfectly matches this medical usage.

reasoning_content:
Let me analyze the context and the candidate senses for the word "treatment" in this medical text.

The sentence is: "For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel..."

Looking at the context:
- This is about medical procedures and medications used to address a disease
- The text discusses "treatment of malignant pleural mesothelioma" and "treatment of non-small cell lung cancer"
- The surrounding context is all about medicines, cancer therapy, and medical interventions

Now let me analyze each sense:

1. sense_key=treatment%1:04:00:: | definition=care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury) | synonyms=intervention
   - This is clearly about medical procedures/applications intended to relieve illness
   - The definition explicitly mentions medical procedures
   - This fits perfectly with the context of treating cancer with drugs

2. sense_key=treatment%1:04:01:: | definition=the management of someone or something | synonyms=handling | examples=the handling of prisoners; the treatment of water sewage
   - This is more general "management" of something
   - While it could fit, the examples (prisoners, water sewage) don't match the medical context

3. sense_key=treatment%1:07:00:: | definition=a manner of dealing with something artistically | examples=his treatment of space borrows from Italian architecture
   - This is clearly about artistic treatment
   - Not relevant to the medical context

4. sense_key=treatment%1:10:00:: | definition=an extended communication (often interactive) dealing with some particular topic | synonyms=discussion, discourse
   - This is about discussing a topic
   - Not relevant to the medical context

The best fit is clearly sense 1 (sense_index: 1), which specifically mentions "medical procedures or applications that are intended to relieve illness or injury" - exactly what the context is about.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cell
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small <t>cell</t> lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

The target word "cell" in "non-small cell lung cancer" refers to the biological sense—the basic structural and functional unit of organisms. In medical terminology, "non-small cell lung cancer" is a classification of lung cancer distinguished by the size and type of cancerous cells. This is clearly the biological meaning (sense 2), not compartments, electrical devices, rooms, or mobile phones.

reasoning_content:
The context is about medical treatment, specifically about cancer medicine (Alimta). Let me analyze the target word "cell" in the phrase "non-small cell lung cancer."

Looking at the candidate senses:
1. Any small compartment (like honeycomb cells) - not relevant
2. The basic structural and functional unit of all organisms (biology) - this is the biological unit
3. Electric cell device - not relevant
4. Small unit in political movement - not relevant
5. Mobile phone - not relevant
6. Monk's room - not relevant
7. Prison cell - not relevant

In the context of "non-small cell lung cancer," the term "cell" clearly refers to biological cells. "Non-small cell lung cancer" is a medical term referring to lung cancer where the cancer cells are not small cell type (as opposed to small cell lung cancer). This is definitely referring to the biological unit - the basic structural and functional unit of organisms.

So the answer should be sense 2: "the basic structural and functional unit of all organisms."


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: effect
Target surface form: effects
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the <t>effects</t> of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=effect%1:19:00:: | definition=a phenomenon that follows and is caused by some previous phenomenon | synonyms=consequence, outcome, result, event, issue, upshot | examples=the magnetic effect was greater when the rod was lengthwise; his decision had depressing consequences for business
2. sense_key=effect%1:07:00:: | definition=an outward appearance | synonyms=impression | examples=he made a good impression; I wanted to create an impression of success
3. sense_key=effect%1:09:00:: | definition=an impression (especially one that is artificial or contrived) | examples=he just did it for effect
4. sense_key=effect%1:10:00:: | definition=the central meaning or theme of a speech or literary work | synonyms=essence, burden, core, gist
5. sense_key=effect%1:07:01:: | definition=(of a law) having legal validity | synonyms=force | examples=the law is still in effect
6. sense_key=effect%1:26:00:: | definition=a symptom caused by an illness or a drug | examples=the effects of sleep loss; the effect of the anesthetic

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The word "effects" in this context refers to the **results or outcomes** of using Alimta as a treatment. The passage is describing how the therapeutic results/consequences of Alimta were measured and compared with other medications in clinical studies. This matches sense 1 (effect%1:19:00::), which defines effect as "a phenomenon that follows and is caused by some previous phenomenon" with synonyms including "consequence, outcome, result."

reasoning_content:
Let me analyze the context to determine which sense of "effects" is being used.

In the sentence: "For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study..."

The word "effects" here refers to the results or outcomes of using Alimta as a treatment. The text is comparing how well Alimta works versus docetaxel.

Let me examine each sense:

1. sense_key=effect%1:19:00:: - "a phenomenon that follows and is caused by some previous phenomenon" | "consequence, outcome, result, event, issue, upshot" - This fits! The effects (results/consequences) of using Alimta are being compared.

2. sense_key=effect%1:07:00:: - "an outward appearance" - This doesn't fit. We're not talking about appearance.

3. sense_key=effect%1:09:00:: - "an impression (especially one that is artificial or contrived)" - Doesn't fit.

4. sense_key=effect%1:10:00:: - "the central meaning or theme of a speech or literary work" - Doesn't fit.

5. sense_key=effect%1:07:01:: - "(of a law) having legal validity" - Doesn't fit.

6. sense_key=effect%1:26:00:: - "a symptom caused by an illness or a drug" - This could potentially fit since we're talking about drug effects, but in context, "effects" refers more to the therapeutic outcomes/results of the treatment rather than side effects or symptoms.

The best fit is sense 1, which relates to "consequences, outcomes, results" - the effects of the treatment are being measured and compared.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: compare
Target surface form: compared
Context:
The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied? For the treatment of malignant pleural mesothelioma, Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before. The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone. For the treatment of non-small cell lung cancer, the effects of Alimta were <t>compared</t> with those of docetaxel (another anticancer medicine) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past. Alimta was also compared with gemcitabine (another anticancer medicine), both in combination with cisplatin, in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past.

Candidate senses:
1. sense_key=compare%2:31:00:: | definition=examine and note the similarities or differences of | examples=John compared his haircut to his friend's; We compared notes after we had both seen the movie
2. sense_key=compare%2:42:00:: | definition=be comparable | examples=This car does not compare with our line of Mercedes
3. sense_key=compare%2:31:01:: | definition=consider or describe as similar, equal, or analogous | synonyms=liken, equate | examples=We can compare the Han dynasty to the Romans; You cannot equate success in financial matters with greed
4. sense_key=compare%2:32:00:: | definition=to form the comparative or superlative form on an adjective or adverb

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The context describes a medical study where the effects of Alimta are being examined and their similarities or differences noted relative to docetaxel. This matches sense 1: "examine and note the similarities or differences of." The sentence exemplifies objective comparison of treatment effects in a research setting, which aligns with the example "John compared his haircut to his friend's."

reasoning_content:
Let me analyze the context and the target word "compared" to determine which sense is most appropriate.

Context analysis:
The sentence is: "For the treatment of non-small cell lung cancer, the effects of Alimta were compared with those of docetaxel (another anticancer medicine) in one study involving 571 patients..."

This is about a medical study where the effects of one drug (Alimta) are being compared with another drug (docetaxel).

Let me look at each sense:

1. Sense 1: "examine and note the similarities or differences of" - This fits well. In a study, you examine and note the similarities or differences between the effects of two drugs.

2. Sense 2: "be comparable" - This is about whether something can be compared (whether it's similar enough to compare). This doesn't fit as well because the sentence is actively comparing, not asking if something is comparable.

3. Sense 3: "consider or describe as similar, equal, or analogous" - This involves describing things as similar or equal. While the context does involve comparing effects, the focus isn't necessarily on describing them as similar, but rather on examining differences and similarities objectively.

4. Sense 4: "to form the comparative or superlative form on an adjective or adverb" - This is about grammar (comparative/superlative forms like "bigger", "biggest"). This doesn't fit at all.

The best fit is Sense 1: "examine and note the similarities or differences of". In the context of a medical study comparing drug effects, the researchers are examining and noting both similarities and differences between the two treatments.

The answer should be 1.