[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
If you want more information on the basis of the CHMP recommendations, read the Scientific Discussion (also part of the EPAR). What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (<t>cancer</t> of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The context clearly discusses cancer in a medical/oncological sense. The document describes Alimta being used to treat malignant tumors (pleural mesothelioma and non-small cell lung cancer), with explicit references to abnormal cell growth, spread to other parts of the body, and chemotherapy. This matches sense 1, which defines cancer as "any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream." The other senses relate to astrology and zoology, which are completely irrelevant to this medical context.

reasoning_content:
Let me analyze the context to find the correct sense for "cancer" in this medical document.

The context clearly discusses:
- A medication (Alimta) containing pemetrexed
- Treatment of "two types of cancer"
- Specific mentions: "pleural mesothelioma (cancer of the lining of the lungs...)"
- "advanced or metastatic non-small cell lung cancer"
- Discussion of chemotherapy (medicines for cancer)
- References to malignant tumors, uncontrolled cell division, and spread to other body parts

This is clearly a medical/oncological context where "cancer" refers to a disease - malignant tumors caused by abnormal cell division.

Looking at the candidate senses:

1. sense_key=cancer%1:26:00:: - "any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream" - This is the MEDICAL sense. Synonyms: malignant neoplastic disease. This matches perfectly with the context.

2. sense_key=cancer%1:18:00:: - A person born under the Cancer zodiac sign. Not relevant.

3. sense_key=cancer%1:17:00:: - A zodiacal constellation. Not relevant.

4. sense_key=cancer%1:15:00:: - The fourth sign of the zodiac. Not relevant.

5. sense_key=cancer%1:05:00:: - A genus of crabs. Not relevant.

The answer is clearly sense 1, which is the medical sense of cancer as a malignant disease/tumor.

The sense_index would be 1.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: lining
Target surface form: lining
Context:
If you want more information on the basis of the CHMP recommendations, read the Scientific Discussion (also part of the EPAR). What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the <t>lining</t> of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells.

Candidate senses:
1. sense_key=lining%1:06:00:: | definition=a protective covering that protects an inside surface | synonyms=liner
2. sense_key=lining%1:06:01:: | definition=a piece of cloth that is used as the inside surface of a garment | synonyms=liner
3. sense_key=lining%1:04:01:: | definition=providing something with a surface of a different material | synonyms=facing
4. sense_key=lining%1:04:00:: | definition=the act of attaching an inside lining (to a garment or curtain etc.)

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The context refers to the pleural membrane, which is the biological tissue covering the lungs. This matches sense 1's definition of "a protective covering that protects an inside surface" - the pleural lining is indeed a protective membrane covering the inside surface of the lung cavity. Senses 2-4 are not applicable as they refer either to clothing/textile applications or to the action of lining rather than the anatomical structure itself.

finish_reason: stop

role: assistant

reasoning_content:
Let me analyze the context and candidate senses for the word "lining" in this medical text.

Context: "pleural mesothelioma (cancer of the <t>lining</t> of the lungs that is usually caused by exposure to asbestos)"

The sentence is describing the anatomical structure - specifically the membrane or protective tissue that covers the lungs. This is the pleura, which is a biological covering/membrane.

Let me evaluate each sense:

1. sense_key=lining%1:06:00:: | definition=a protective covering that protects an inside surface | synonyms=liner
   - This refers to a protective covering on the inside surface of something
   - In the medical context, the pleural lining is indeed a protective membrane covering the lungs

2. sense_key=lining%1:06:01:: | definition=a piece of cloth that is used as the inside surface of a garment | synonyms=liner
   - This is specifically about fabric used in clothing
   - Not applicable to lung anatomy

3. sense_key=lining%1:04:01:: | definition=providing something with a surface of a different material | synonyms=facing
   - This is about the action of adding a surface
   - Not the noun referring to the anatomical structure itself

4. sense_key=lining%1:04:00:: | definition=the act of attaching an inside lining (to a garment or curtain etc.)
   - This is about the process/action
   - Not the noun referring to the anatomical structure

The best fit is sense 1: "a protective covering that protects an inside surface" because:
- The pleural lining is a protective covering
- It covers/protects the inner surface of the lungs
- The definition matches the anatomical usage perfectly
- This is the correct sense index to select.

type: thinking

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cause
Target surface form: caused
Context:
If you want more information on the basis of the CHMP recommendations, read the Scientific Discussion (also part of the EPAR). What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually <t>caused</t> by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells.

Candidate senses:
1. sense_key=cause%2:36:00:: | definition=give rise to; cause to happen or occur, not always intentionally | synonyms=do, make | examples=cause a commotion; make a stir
2. sense_key=cause%2:32:00:: | definition=cause to do; cause to act in a specified manner | synonyms=induce, stimulate, have, get, make | examples=The ads induced me to buy a VCR; My children finally got me to buy a computer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

content:
```json
{"sense_index": 1}
```

reasoning_content:
Let me analyze the context and the two candidate senses for the word "caused" in this medical text.

The sentence is: "pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos)"

Let me understand what "caused" means here:
- The cancer is "caused by exposure to asbestos"
- This means that exposure to asbestos "gives rise to" or "brings about" the development of pleural mesothelioma
- It's describing a causal relationship where the exposure results in the cancer

Now let me look at the two senses:

Sense 1: "give rise to; cause to happen or occur, not always intentionally"
- Synonyms: do, make
- Examples: cause a commotion; make a stir
- Definition focuses on causing something to happen or occur

Sense 2: "cause to do; cause to act in a specified manner"
- Synonyms: induce, stimulate, have, get, make
- Examples: The ads induced me to buy a VCR; My children finally got me to buy a computer
- Definition focuses on causing someone/something to perform an action

In the context "caused by exposure to asbestos," the exposure is causing the disease to develop. This is about one event/condition bringing about another event/condition (the cancer occurring), not about causing something to perform an action.

Sense 1 is clearly the better fit because:
- It describes "give rise to" and "cause to happen or occur"
- The cancer is caused (brought about) by exposure to asbestos
- This is about an event/condition coming into being

Sense 2 would be more about causing someone or something to do something actively, which doesn't apply here.

The answer should be sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: use
Target surface form: used
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is <t>used</t> together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=use%2:34:01:: | definition=put into service; make work or employ for a particular purpose or for its inherent or natural purpose | synonyms=utilize, utilise, apply, employ | examples=use your head!; we only use Spanish at home
2. sense_key=use%2:34:02:: | definition=take or consume (regularly or habitually) | synonyms=habituate | examples=She uses drugs rarely
3. sense_key=use%2:34:00:: | definition=use up, consume fully | synonyms=expend | examples=The legislature expended its time on school questions
4. sense_key=use%2:41:14:: | definition=seek or achieve an end by using to one's advantage | examples=She uses her influential friends to get jobs; The president's wife used her good connections
5. sense_key=use%2:41:04:: | definition=avail oneself to | synonyms=practice, apply | examples=apply a principle; practice a religion
6. sense_key=use%2:41:03:: | definition=habitually do something (use only in the past tense) | examples=She used to call her mother every week but now she calls only occasionally; I used to get sick when I ate in that dining hall

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The context describes Alimta being employed or put into service for a specific purpose—treating cancer. The phrase "Alimta is used together with cisplatin" indicates the medication is being applied/employed for its therapeutic purpose, which matches sense 1: "put into service; make work or employ for a particular purpose." This is the standard medical/technical usage where a substance is applied to accomplish a specific goal, rather than consumption (sense 2), depletion (sense 3), manipulation (sense 4), or habitual past actions (sense 6).

reasoning_content:
Let me analyze the context to determine which sense of "used" is being employed.

The target sentence is: "Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable..."

Let's examine each candidate sense:

1. sense_key=use%2:34:01:: - "put into service; make work or employ for a particular purpose" - This is about employing something for a purpose. In the context, Alimta is being employed/used to treat cancer. This fits well.

2. sense_key=use%2:34:02:: - "take or consume (regularly or habitually)" - This is about consuming something. While drugs/medicines can be consumed, this sense emphasizes regular or habitual consumption, particularly of substances. The example "She uses drugs rarely" shows this is about consuming substances.

3. sense_key=use%2:34:00:: - "use up, consume fully" - This means to deplete or exhaust something. The context doesn't suggest Alimta is being consumed or depleted.

4. sense_key=use%2:41:14:: - "seek or achieve an end by using to one's advantage" - This is about using something manipulatively to gain an advantage. The context doesn't suggest this.

5. sense_key=use%2:41:04:: - "avail oneself to; practice, apply" - This could work but is less direct than sense 1.

6. sense_key=use%2:41:03:: - "habitually do something (use only in the past tense)" - This is specifically for past habitual actions. While "used" is past tense, the context is not describing a habitual past action but rather the function/purpose of the medicine.

The best fit is sense 1: "put into service; make work or employ for a particular purpose". Alimta is being put into service/employed to treat cancer. This is the straightforward medical application sense.
The sense index is 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer <t>medicine</t>) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

The target word "medicine" refers to cisplatin, which is described as "another anticancer medicine." In this medical context, the word clearly denotes a medicinal drug or medication used to treat disease symptoms (cancer), making it sense 2: "something that treats or prevents or alleviates the symptoms of disease."

reasoning_content:
Let me analyze the context and the candidate senses.

The target word is "medicine" and it appears in this context:
"Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable..."

The word "medicine" here is clearly referring to a medicinal substance or drug - specifically cisplatin is described as "another anticancer medicine."

Let me look at the candidate senses:

1. sense_key=medicine%1:09:00:: - "the branches of medical science that deal with nonsurgical techniques" (medical specialty) - This doesn't fit. The context isn't talking about medical specialties.

2. sense_key=medicine%1:06:00:: - "(medicine) something that treats or prevents or alleviates the symptoms of disease" with synonyms "medication, medicament, medicinal drug" - This fits perfectly. Cisplatin is a medicinal drug used to treat cancer.

3. sense_key=medicine%1:04:00:: - "the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries" (practice of medicine) - This would refer to the profession or field of medicine, not a specific drug.

4. sense_key=medicine%1:04:02:: - "punishment for one's actions" (synonyms: music) - This is clearly not relevant to the context.

The answer is sense 2. The word "medicine" in this context refers to a medicinal drug or medication (cisplatin), which treats or prevents or alleviates symptoms of disease.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the <t>cancer</t> is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The context clearly refers to cancer as a medical condition. The passage discusses malignant growths (pleural mesothelioma and non-small cell lung cancer), describes uncontrolled cell division and spread to other parts of the body, and discusses treatment with anticancer medicines. This matches sense 1 perfectly: "any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream."

reasoning_content:
The target word is "cancer" in the context of medical information about Alimta, a drug used to treat pleural mesothelioma and non-small cell lung cancer.

Looking at the context:
- The passage is about Alimta, a medicine
- It discusses "cancer of the lining of the lungs"
- It mentions "pleural mesothelioma (cancer of the lining of the lungs...)"
- It discusses "advanced or metastatic non-small cell lung cancer"
- The passage uses phrases like "malignant growth or tumor"

This is clearly referring to a medical condition - a disease involving abnormal and uncontrolled cell division.

Let me review the candidate senses:
1. "any malignant growth or tumor caused by abnormal and uncontrolled cell division" - This matches perfectly with the medical context
2. A person born under the sign of Cancer (astrology) - Not relevant
3. A zodiacal constellation - Not relevant
4. The fourth sign of the zodiac - Not relevant
5. Type genus of the family Cancridae (a crab genus) - Not relevant

The answer is clearly sense 1, which is the medical definition of cancer as a malignant neoplastic disease.

The sense_index should be 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: remove
Target surface form: removed
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be <t>removed</t> by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=remove%2:30:00:: | definition=remove something concrete, as by lifting, pushing, or taking off, or remove something abstract | synonyms=take, take away, withdraw | examples=remove a threat; remove a wrapper
2. sense_key=remove%2:41:00:: | definition=remove from a position or an office
3. sense_key=remove%2:40:00:: | definition=dispose of | synonyms=get rid of | examples=Get rid of these old shoes!; The company got rid of all the dead wood
4. sense_key=remove%2:41:02:: | definition=cause to leave | synonyms=take out, move out | examples=The teacher took the children out of the classroom
5. sense_key=remove%2:38:00:: | definition=shift the position or location of, as for business, legal, educational, or military purposes | synonyms=transfer | examples=He removed his children to the countryside; Remove the troops to the forest surrounding the city
6. sense_key=remove%2:30:01:: | definition=go away or leave | synonyms=absent | examples=He absented himself
7. sense_key=remove%2:41:01:: | definition=kill intentionally and with premeditation | synonyms=murder, slay, hit, dispatch, bump off, off | examples=The mafia boss ordered his enemies murdered
8. sense_key=remove%2:30:02:: | definition=get rid of something abstract | synonyms=take away | examples=The death of her mother removed the last obstacle to their marriage; God takes away your sins

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The context refers to cancer that "cannot be removed by surgery alone." In this medical/surgical context, "removed" means to physically take out or excise the tumor/cancer tissue through surgical intervention. This aligns with sense 1, which describes removing something concrete by lifting, pushing, or taking off—exactly what surgical removal of a tumor entails.

reasoning_content:
Let me analyze the context where "removed" appears:

"Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone)"

The context indicates that "removed" refers to cancer that cannot be taken away or eliminated by surgery alone.

Let me examine the candidate senses:

1. sense_key=remove%2:30:00:: - "remove something concrete, as by lifting, pushing, or taking off, or remove something abstract" - This fits - you can remove something concrete (like a tumor/cancer).

2. sense_key=remove%2:41:00:: - "remove from a position or an office" - This is about removing someone from office, doesn't fit.

3. sense_key=remove%2:40:00:: - "dispose of" - Similar to sense 1, but more about getting rid of/disposing.

4. sense_key=remove%2:41:02:: - "cause to leave" - This is about people leaving, doesn't fit.

5. sense_key=remove%2:38:00:: - "shift the position or location of" - This is about moving something to a different place, doesn't quite fit.

6. sense_key=remove%2:30:01:: - "go away or leave" - This is intransitive, doesn't fit.

7. sense_key=remove%2:41:01:: - "kill intentionally and with premeditation" - This is slang for murder, doesn't fit.

8. sense_key=remove%2:30:02:: - "get rid of something abstract" - This is specifically about abstract things, but the context is about removing a concrete tumor.

The best fit is sense 1: "remove something concrete, as by lifting, pushing, or taking off, or remove something abstract" - because in the medical context, you're literally trying to remove the cancer/tumor through surgery.
Sense 3 about disposing could work too, but sense 1 more precisely captures the surgical act of excising the tumor. In this medical context, "removed" specifically means to surgically extract the cancer, which aligns directly with physically taking something off or out.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: surgery
Target surface form: surgery
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by <t>surgery</t> alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=surgery%1:09:00:: | definition=the branch of medical science that treats disease or injury by operative procedures | examples=he is professor of surgery at the Harvard Medical School
2. sense_key=surgery%1:06:01:: | definition=a room where a doctor or dentist can be consulted | examples=he read the warning in the doctor's surgery
3. sense_key=surgery%1:06:00:: | definition=a room in a hospital equipped for the performance of surgical operations | synonyms=operating room, OR, operating theater, operating theatre | examples=great care is taken to keep the operating rooms aseptic
4. sense_key=surgery%1:04:01:: | definition=a medical procedure involving an incision with instruments; performed to repair damage or arrest disease in a living body | synonyms=operation, surgical operation, surgical procedure, surgical process | examples=they will schedule the operation as soon as an operating room is available; he died while undergoing surgery

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 4}
```

The context describes cancer that "cannot be removed by surgery alone," clearly referring to a surgical procedure/operation as a medical intervention to treat the disease. This matches sense 4, which defines surgery as "a medical procedure involving an incision with instruments; performed to repair damage or arrest disease in a living body," with synonyms including operation, surgical operation, and surgical procedure.

reasoning_content:
Let me analyze the context and the target word "surgery" to determine which sense is most appropriate.

The context is from a medical document about Alimta, a cancer treatment. The sentence containing "surgery" is:
"Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone)"

This is discussing whether the cancer can be removed by a procedure. The document is explaining that Alimta is used when the cancer cannot be removed by surgery alone - meaning a surgical procedure/operation cannot fully remove it.

Let me examine each sense:

1. sense_key=surgery%1:09:00:: - "the branch of medical science that treats disease or injury by operative procedures" - This is about surgery as a field/discipline. The context is not discussing surgery as a medical branch, but rather surgery as a procedure for treatment.

2. sense_key=surgery%1:06:01:: - "a room where a doctor or dentist can be consulted" - This refers to a doctor's office/surgery room. This doesn't fit the context at all.

3. sense_key=surgery%1:06:00:: - "a room in a hospital equipped for the performance of surgical operations" - This is about an operating room. The context is not discussing a physical room but a procedure.

4. sense_key=surgery%1:04:01:: - "a medical procedure involving an incision with instruments; performed to repair damage or arrest disease in a living body" - This refers to surgery as a procedure/operation. The synonyms include "operation, surgical operation, surgical procedure." The context "cannot be removed by surgery alone" refers to a surgical procedure/operation that could potentially remove the cancer.

The context clearly indicates "surgery" refers to a medical procedure that could potentially remove the cancer. This matches sense 4 perfectly.
The correct sense is sense 4, which captures surgery as a specific medical intervention rather than a location or medical discipline.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: alone
Target surface form: alone
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery <t>alone</t>) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=alone%5:00:00:unsocial:00 | definition=isolated from others | examples=could be alone in a crowded room; was alone with her thoughts
2. sense_key=alone%5:00:00:unaccompanied:00 | definition=lacking companions or companionship | synonyms=lone, lonely, solitary | examples=he was alone when we met him; she is alone much of the time
3. sense_key=alone%5:00:00:exclusive:00 | definition=exclusive of anyone or anything else | synonyms=only | examples=she alone believed him; cannot live by bread alone
4. sense_key=alone%5:00:00:incomparable:00 | definition=radically distinctive and without equal | synonyms=unique, unequaled, unequalled, unparalleled | examples=he is alone in the field of microbiology; this theory is altogether alone in its penetration of the problem

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 3}
```

The word "alone" in "cannot be removed by surgery alone" uses the exclusive sense meaning "only" or "exclusively." The cancer cannot be removed by surgery exclusively (on its own), indicating that additional treatment (cisplatin) is needed. This matches sense 3's definition of "exclusive of anyone or anything else" with the synonym "only."

reasoning_content:
Let me analyze the context and the candidate senses for the word "alone" in this medical text.

The sentence in question is: "Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone)"

The word "alone" here is being used to mean "solely" or "by itself" - meaning that surgery alone (meaning surgery on its own, without other treatments) cannot remove the cancer.

Let me check each sense:

1. sense_key=alone%5:00:00:unsocial:00 - "isolated from others" - This doesn't fit. The context isn't about being isolated or socially separated.

2. sense_key=alone%5:00:00:unaccompanied:00 - "lacking companions or companionship" - This doesn't fit either. The context isn't about lacking companionship.

3. sense_key=alone%5:00:00:exclusive:00 - "exclusive of anyone or anything else" with synonyms "only" - This fits! The example "she alone believed him" or "cannot live by bread alone" shows that "alone" means "exclusively" or "only". In the context, "cannot be removed by surgery alone" means "cannot be removed by surgery exclusively/only" - i.e., surgery by itself cannot remove the cancer.

4. sense_key=alone%5:00:00:incomparable:00 - "radically distinctive and without equal" - This doesn't fit the context.

The best match is sense 3, which uses "alone" to mean "exclusively" or "only". The context "cannot be removed by surgery alone" means surgery exclusively/only cannot remove the cancer.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: spread
Target surface form: spread
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has <t>spread</t>, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=spread%2:35:00:: | definition=distribute or disperse widely | synonyms=distribute | examples=The invaders spread their language all over the country
2. sense_key=spread%2:35:07:: | definition=become distributed or widespread | synonyms=propagate | examples=the infection spread; Optimism spread among the population
3. sense_key=spread%2:42:00:: | definition=spread across or over | synonyms=overspread | examples=A big oil spot spread across the water
4. sense_key=spread%2:35:03:: | definition=spread out or open from a closed or folded state | synonyms=unfold, spread out, open | examples=open the map; spread your arms
5. sense_key=spread%2:32:00:: | definition=cause to become widely known | synonyms=circulate, circularize, circularise, distribute, disseminate, propagate | examples=spread information; circulate a rumor
6. sense_key=spread%2:32:02:: | definition=become widely known and passed on | synonyms=go around, circulate | examples=the rumor spread; the story went around in the office
7. sense_key=spread%2:38:00:: | definition=strew or distribute over an area | synonyms=scatter, spread out | examples=He spread fertilizer over the lawn; scatter cards across the table
8. sense_key=spread%2:38:02:: | definition=move outward | synonyms=diffuse, spread out, fan out | examples=The soldiers fanned out
9. sense_key=spread%2:35:12:: | definition=cover by spreading something over | examples=spread the bread with cheese
10. sense_key=spread%2:35:13:: | definition=distribute over a surface in a layer | examples=spread cheese on a piece of bread

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

The context describes cancer that "has spread, or is likely to spread easily, to other parts of the body." This refers to cancer becoming distributed or widespread throughout the body. Sense 2 ("become distributed or widespread") with its example "the infection spread" is the most appropriate match for this medical usage, where a disease/condition becomes distributed across multiple body parts.

reasoning_content:
Let me analyze the context to determine the best sense for "spread" in this medical document about Alimta.

The sentence is: "Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body)"

Here, "spread" refers to cancer that has spread to other parts of the body. This is about the cancer becoming distributed or widespread in the body.

Let me look at the candidate senses:

1. distribute or disperse widely - Example: "The invaders spread their language all over the country"
2. become distributed or widespread - Example: "the infection spread; Optimism spread among the population"
3. spread across or over - Example: "A big oil spot spread across the water"
4. spread out or open from a closed or folded state - Example: "open the map; spread your arms"
5. cause to become widely known - Example: "spread information; circulate a rumor"
6. become widely known and passed on - Example: "the rumor spread; the story went around in the office"
7. strew or distribute over an area - Example: "He spread fertilizer over the lawn; scatter cards across the table"
8. move outward - Example: "The soldiers fanned out"
9. cover by spreading something over - Example: "spread the bread with cheese"
10. distribute over a surface in a layer - Example: "spread cheese on a piece of bread"

In the medical context, "the cancer has spread, or is likely to spread easily, to other parts of the body" - this is about the cancer becoming distributed or widespread throughout the body. The infection spreading example in sense 2 is very similar to this medical context.

Sense 2 "become distributed or widespread" with examples "the infection spread; Optimism spread among the population" is the best match. The infection spreading is directly analogous to cancer spreading to other parts of the body.
The answer is sense index 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: likely
Target surface form: likely
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is <t>likely</t> to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=likely%3:00:00:: | definition=has a good chance of being the case or of coming about | examples=these services are likely to be available to us all before long; she is likely to forget
2. sense_key=likely%3:00:04:: | definition=likely but not certain to be or become true or real | synonyms=probable | examples=a likely result; he foresaw a probable loss
3. sense_key=likely%5:00:00:prospective:00 | definition=expected to become or be; in prospect | synonyms=potential | examples=potential clients
4. sense_key=likely%5:00:00:credible:00 | definition=within the realm of credibility | examples=not a very likely excuse

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The context shows "likely" being used to describe the probability that cancer "will spread" to other parts of the body. This matches sense 1, which means "has a good chance of being the case or of coming about," as evidenced by the examples "these services are likely to be available" and "she is likely to forget." The word describes a probable or probable future event in the medical context.

reasoning_content:
Let me analyze the context and the candidate senses for the word "likely".

The sentence is: "Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body)"

In this context, "likely" is describing the probability that cancer "will spread" to other parts of the body. It's being used as an adjective meaning "probable" or "having a good chance of happening."

Let me examine each sense:

1. sense_key=likely%3:00:00:: - "has a good chance of being the case or of coming about" with examples like "these services are likely to be available" and "she is likely to forget". This fits the context perfectly - the cancer is likely (has a good chance) to spread.

2. sense_key=likely%3:00:04:: - "likely but not certain to be or become true or real" with synonym "probable" and examples like "a likely result" and "he foresaw a probable loss". This also seems very similar to sense 1.

3. sense_key=likely%5:00:00:prospective:00 - "expected to become or be; in prospect" with synonym "potential". This is more about what is expected or in prospect, which doesn't quite fit.

4. sense_key=likely%5:00:00:credible:00 - "within the realm of credibility". This is about whether something is believable/credible, which doesn't fit the context.

Between senses 1 and 2, they're very similar. Both refer to probability. However, sense 1 ("has a good chance of being the case or of coming about") seems to be the more general and primary sense, while sense 2 appears to be a variant with "probable" as a synonym. Given the context of "is likely to spread", sense 1 seems like the best fit.
The sense index for sense 1 would be 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: spread
Target surface form: spread
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to <t>spread</t> easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=spread%2:35:00:: | definition=distribute or disperse widely | synonyms=distribute | examples=The invaders spread their language all over the country
2. sense_key=spread%2:35:07:: | definition=become distributed or widespread | synonyms=propagate | examples=the infection spread; Optimism spread among the population
3. sense_key=spread%2:42:00:: | definition=spread across or over | synonyms=overspread | examples=A big oil spot spread across the water
4. sense_key=spread%2:35:03:: | definition=spread out or open from a closed or folded state | synonyms=unfold, spread out, open | examples=open the map; spread your arms
5. sense_key=spread%2:32:00:: | definition=cause to become widely known | synonyms=circulate, circularize, circularise, distribute, disseminate, propagate | examples=spread information; circulate a rumor
6. sense_key=spread%2:32:02:: | definition=become widely known and passed on | synonyms=go around, circulate | examples=the rumor spread; the story went around in the office
7. sense_key=spread%2:38:00:: | definition=strew or distribute over an area | synonyms=scatter, spread out | examples=He spread fertilizer over the lawn; scatter cards across the table
8. sense_key=spread%2:38:02:: | definition=move outward | synonyms=diffuse, spread out, fan out | examples=The soldiers fanned out
9. sense_key=spread%2:35:12:: | definition=cover by spreading something over | examples=spread the bread with cheese
10. sense_key=spread%2:35:13:: | definition=distribute over a surface in a layer | examples=spread cheese on a piece of bread

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

reasoning_content:
Let me analyze the context to understand which sense of "spread" is being used.

The sentence is: "Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body)"

So we're talking about cancer that "has spread, or is likely to spread easily, to other parts of the body."

This is describing the movement/distribution of cancer cells to different parts of the body. The cancer is moving from one location to other parts.

Let me look at the candidate senses:

1. "distribute or disperse widely" - This is about actively distributing something. Example: "The invaders spread their language all over the country" - this is more about the invaders actively spreading language.

2. "become distributed or widespread" - This is about something becoming distributed or widespread. Examples: "the infection spread; Optimism spread among the population" - this is intransitive/passive, where something spreads on its own. The infection spreading is very similar to cancer spreading.

3. "spread across or over" - spatial spreading. Example: "A big oil spot spread across the water"

4. "spread out or open from a closed or folded state" - This is about opening or unfolding. Not relevant here.

5. "cause to become widely known" - This is about information/rumors. Not about physical spreading.

6. "become widely known and passed on" - Again about information. Not relevant.

7. "strew or distribute over an area" - This is about scattering. More intentional. Not quite right.

8. "move outward" - This could work, but it's more about spatial movement in directions.

9. "cover by spreading something over" - Not relevant, this is about applying something.

10. "distribute over a surface in a layer" - Not relevant, this is about applying in a layer.

The cancer "spreading" to other parts of the body is similar to an infection spreading.

The disease becomes distributed across different body parts through its own progression, without external intervention. This aligns with sense 2: "become distributed or widespread," just like how an infection spreads on its own.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: easily
Target surface form: easily
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread <t>easily</t>, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=easily%4:02:01:: | definition=with ease (`easy' is sometimes used informally for `easily') | synonyms=easy | examples=she was easily excited; was easily confused
2. sense_key=easily%4:02:06:: | definition=without question | examples=easily the best book she's written
3. sense_key=easily%4:02:05:: | definition=indicating high probability; in all likelihood | synonyms=well | examples=I might well do it; a mistake that could easily have ended in disaster

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The word "easily" in this context describes how the malignant cancer is likely to spread to other parts of the body. It indicates that the cancer spreads without difficulty or resistance, which aligns with sense 1 ("with ease"). The examples provided ("she was easily excited; was easily confused") show the same usage pattern where "easily" modifies how readily or without difficulty something occurs.

reasoning_content:
Let me analyze the context and candidate senses for the word "easily."

Context: "cancer... that is likely to spread easily, to other parts of the body"

This sentence is describing how a cancer is likely to spread - it's saying the cancer is likely to spread in an easy manner (without difficulty), or is readily able to spread to other parts of the body.

Let me look at each candidate:

1. sense_key=easily%4:02:01:: | definition=with ease (`easy' is sometimes used informally for `easily') | synonyms=easy | examples=she was easily excited; was easily confused
   - This means "with ease" - something done or happening readily without difficulty
   - The cancer spreading easily = spreading without difficulty/readily

2. sense_key=easily%4:02:06:: | definition=without question | examples=easily the best book she's written
   - This means "undoubtedly" or "clearly" - used when something is obviously or certainly true
   - This doesn't fit well with "spread easily"

3. sense_key=easily%4:02:05:: | definition=indicating high probability; in all likelihood | synonyms=well | examples=I might well do it; a mistake that could easily have ended in disaster
   - This indicates probability - "could easily have ended in disaster" means "could well have/probably would have"
   - But in our context "is likely to spread easily" - this seems more about the manner of spreading rather than probability

Looking at the context again: "is likely to spread easily, to other parts of the body"

The word "easily" here describes HOW the cancer spreads - it spreads without resistance/difficulty. This matches sense 1, which is "with ease."

Actually, wait. Let me reconsider sense 3. "is likely to spread easily" could be interpreted as "is likely to spread (with high probability)" where "easily" modifies "spread" to indicate probability... But that seems less natural.
Sense 1 best captures the meaning—the cancer spreads without resistance or difficulty to other parts of the body.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: other
Target surface form: other
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to <t>other</t> parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=other%3:00:00:: | definition=not the same one or ones already mentioned or implied; - the White Queen | examples=today isn't any other day; the construction of highways and other public works
2. sense_key=other%5:00:00:past:00 | definition=recently past | examples=the other evening
3. sense_key=other%5:00:02:past:00 | definition=belonging to the distant past | synonyms=early, former | examples=the early inhabitants of Europe; former generations
4. sense_key=other%5:00:00:strange:00 | definition=very unusual; different in character or quality from the normal or expected; - Lance Morrow | examples=a strange, other dimension...where his powers seemed to fail

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The word "other" in this context means "not the same one or ones already mentioned or implied." The passage discusses cancer spreading to "other parts of the body"—referring to body parts different from the lungs/pleural lining already mentioned. This matches sense 1's definition and examples perfectly (e.g., "the construction of highways and other public works" where "other" refers to works not yet specified).

reasoning_content:
Let me analyze the context for the word "other" in this sentence:

"Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body)"

In this context, "other" is referring to parts of the body that are different from the primary location mentioned. The cancer spreads to parts of the body that are not the originally mentioned site.

Let me examine each sense:

1. sense_key=other%3:00:00:: - "not the same one or ones already mentioned or implied" - This describes something that is different from what was already mentioned. In the context, "other parts" means parts of the body that are different from the lungs/lining mentioned. This fits perfectly.

2. sense_key=other%5:00:00:past:00 - "recently past" - This doesn't fit at all.

3. sense_key=other%5:00:02:past:00 - "belonging to the distant past" - This doesn't fit at all.

4. sense_key=other%5:00:00:strange:00 - "very unusual; different in character or quality from the normal or expected" - While "other" can mean different/unusual, this sense implies something strange or unusual in character, which doesn't fit the medical context here.

The best fit is sense 1, which is about something not being the same as what was already mentioned or implied. The phrase "other parts of the body" clearly refers to body parts that are different from the lungs (which was the primary focus).

The answer is 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: part
Target surface form: parts
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other <t>parts</t> of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=part%1:24:00:: | definition=something determined in relation to something that includes it | synonyms=portion, component part, component, constituent | examples=he wanted to feel a part of something bigger than himself; I read a portion of the manuscript
2. sense_key=part%1:06:00:: | definition=something less than the whole of a human artifact | synonyms=portion | examples=the rear part of the house; glue the two parts together
3. sense_key=part%1:17:00:: | definition=a portion of a natural object | synonyms=piece | examples=they analyzed the river into three parts; he needed a piece of granite
4. sense_key=part%1:09:02:: | definition=that which concerns a person with regard to a particular role or situation | examples=it requires vigilance on our part; they resisted every effort on his part
5. sense_key=part%1:15:00:: | definition=the extended spatial location of something | synonyms=region | examples=the farming regions of France; religions in all parts of the world
6. sense_key=part%1:04:01:: | definition=the actions and activities assigned to or required or expected of a person or group | synonyms=function, office, role | examples=the function of a teacher; the government must do its part
7. sense_key=part%1:09:01:: | definition=an actor's portrayal of someone in a play | synonyms=character, role, theatrical role, persona | examples=she played the part of Desdemona
8. sense_key=part%1:21:00:: | definition=assets belonging to or due to or contributed by an individual person or group | synonyms=share, portion, percentage | examples=he wanted his share in cash
9. sense_key=part%1:09:00:: | definition=one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division | examples=the written part of the exam; the finance section of the company
10. sense_key=part%1:08:01:: | definition=a line of scalp that can be seen when sections of hair are combed in opposite directions | synonyms=parting | examples=his part was right in the middle
11. sense_key=part%1:10:00:: | definition=the melody carried by a particular voice or instrument in polyphonic music | synonyms=voice | examples=he tried to sing the tenor part
12. sense_key=part%1:04:03:: | definition=the part played by a person in bringing about a result | synonyms=contribution, share | examples=I am proud of my contribution in advancing the project; they all did their share of the work

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 5}
```

The word "parts" in "spread easily, to other parts of the body" refers to different regions or locations within the body. Sense 5 with the definition "the extended spatial location of something" and the synonym "region" best captures this meaning. The example "religions in all parts of the world" parallels the usage here, where "parts" denotes geographic/spatial divisions.

reasoning_content:
Let me analyze the context for the word "parts" in this medical text.

The relevant sentence is: "Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body)"

Here, "parts" refers to different regions or locations in the body. The cancer has spread or is likely to spread to other areas of the body.

Let me examine the candidate senses:

1. **sense 1** - component/portion of something larger - not quite right, this is about being a component part

2. **sense 2** - something less than the whole of a human artifact - not right, the body is not an artifact

3. **sense 3** - a portion of a natural object - this could work, as the body is natural, but it's more about discrete pieces

4. **sense 4** - concern regarding a role - not applicable here

5. **sense 5** - the extended spatial location of something; synonyms=region - This seems very appropriate! The definition explicitly mentions "region" as a synonym, and the examples include "religions in all parts of the world" which is very similar to "other parts of the body"

6. **sense 6** - actions/activities assigned to a person - not applicable

7. **sense 7** - actor's role - not applicable

8. **sense 8** - assets/share - not applicable

9. **sense 9** - portions into which something is divided - could work but more about abstract division

10. **sense 10** - hair part - not applicable

11. **sense 11** - music part - not applicable

12. **sense 12** - contribution - not applicable

The best match is **sense 5** - "the extended spatial location of something" with synonym "region" and examples like "religions in all parts of the world". This perfectly fits "other parts of the body" meaning different regions/locations within the body.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: body
Target surface form: body
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the <t>body</t>), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=body%1:08:00:: | definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
2. sense_key=body%1:14:00:: | definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium; the student body
3. sense_key=body%1:08:02:: | definition=a natural object consisting of a dead animal or person | synonyms=dead body | examples=they found the body in the lake
4. sense_key=body%1:17:00:: | definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. sense_key=body%1:08:01:: | definition=the body excluding the head and neck and limbs | synonyms=torso, trunk | examples=they moved their arms and legs and bodies
6. sense_key=body%1:14:02:: | definition=a collection of particulars considered as a system | examples=a body of law; a body of doctrine
7. sense_key=body%1:07:00:: | definition=the property of holding together and retaining its shape | synonyms=consistency, consistence, eubstance | examples=wool has more body than rayon; when the dough has enough consistency it is ready to bake
8. sense_key=body%1:10:00:: | definition=the central message of a communication | examples=the body of the message was short
9. sense_key=body%1:07:01:: | definition=the main mass of a thing
10. sense_key=body%1:06:01:: | definition=a resonating chamber in a musical instrument (as the body of a violin) | synonyms=soundbox
11. sense_key=body%1:06:00:: | definition=the external structure of a vehicle | examples=the body of the car was badly rusted

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The context discusses cancer potentially spreading "to other parts of the body." This refers to the entire physical structure of an organism (the human body), which is definition 1. The phrase indicates concern about the disease spreading throughout the whole person's physical structure, matching the sense "the entire structure of an organism (an animal, plant, or human being)."

reasoning_content:
Let me analyze the context to determine the correct sense of "body" in this medical document about Alimta.

The sentence is: "Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells."

In this context, "body" refers to the entire physical structure of a person or organism - specifically, the human body that could have cancer spread to various parts. This is referring to the whole organism.

Looking at the candidate senses:
1. sense_key=body%1:08:00:: | definition=the entire structure of an organism (an animal, plant, or human being) | examples=he felt as if his whole body were on fire - This fits perfectly. "Other parts of the body" refers to the entire structure of the organism.

2. sense_key=body%1:14:00:: | definition=a group of persons associated by some common tie or occupation and regarded as an entity - Not applicable here

3. sense_key=body%1:08:02:: | definition=a natural object consisting of a dead animal or person - Not applicable, we're talking about living organisms

4. sense_key=body%1:17:00:: | definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects - Too general/broad

5. sense_key=body%1:08:01:: | definition=the body excluding the head and neck and limbs - This is torso/trunk, which is too specific. The context is about cancer spreading to "other parts" which could mean the whole body.

6. sense_key=body%1:14:02:: | definition=a collection of particulars considered as a system - Not applicable
The remaining senses don't apply to this medical usage. Sense 1 is the clear match—it captures the complete organism and aligns with how the text discusses cancer potentially spreading throughout different regions. The answer is sense index 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in <t>patients</t> who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The word "patients" in this context refers to actual people receiving medical care for cancer treatment. The text is discussing a medication (Alimta) and describing which people (those who have not received chemotherapy) should use it. This is a straightforward use of "patient" as a noun meaning a person who requires medical care, not a linguistic/grammatical semantic role.

reasoning_content:
Let me analyze the context and the two candidate senses for "patients" in this medical text.

The sentence reads: "Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in <t>patients</t> who have not received chemotherapy..."

Let me look at both senses:

1. Sense 1: "a person who requires medical care" - This is a straightforward noun sense referring to people who are receiving medical treatment or care. Examples include "the number of emergency patients has grown rapidly." This makes sense in the context - the text is talking about people who need medical treatment for cancer.

2. Sense 2: "the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause" - This is a linguistic/grammatical sense referring to the semantic role of a patient in a clause. The synonyms are "affected role, patient role."

In the given context, "patients" is being used as a noun to refer to actual people who are receiving medical treatment. The word is used concretely to identify the group of people for whom the medication is intended. This is clearly sense 1 - a person who requires medical care.

Sense 2 is a linguistic/semantic role term, not a concrete reference to people. It wouldn't be used this way in a medical text describing a medication.

The answer should be sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicines
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (<t>medicines</t> for cancer) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

The context "medicines for cancer" clearly refers to substances or medications used to treat disease. The phrase describes chemotherapy drugs (like pemetrexed in Alimta and cisplatin) that are used to alleviate or treat cancer symptoms. This matches sense 2, which defines medicine as "something that treats or prevents or alleviates the symptoms of disease" with synonyms medication, medicament, and medicinal drug.

reasoning_content:
Let me analyze the context to find the best sense for "medicines" in the phrase "medicines for cancer".

The sentence reads: "Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable... in patients who have not received chemotherapy (<t>medicines</t> for cancer) before..."

The context is about medical treatment. The word "medicines" is explicitly referring to "medicines for cancer" - these are substances used to treat cancer.

Let me examine the candidate senses:

1. sense_key=medicine%1:09:00:: - "the branches of medical science that deal with nonsurgical techniques" - This refers to medical specialties, not to medications themselves. Not appropriate.

2. sense_key=medicine%1:06:00:: - "(medicine) something that treats or prevents or alleviates the symptoms of disease" with synonyms "medication, medicament, medicinal drug" - This is the definition of a substance/medication used to treat disease. The examples would be medications like chemotherapy drugs. This fits perfectly.

3. sense_key=medicine%1:04:00:: - "the learned profession that is mastered by graduate training in a medical school..." - This refers to the profession or field of medicine, not medications. Not appropriate.

4. sense_key=medicine%1:04:02:: - "punishment for one's actions" - This is a metaphorical usage. Not relevant here.

In this context, "medicines for cancer" clearly refers to substances or medications used to treat cancer. This is sense 2, which defines medicine as "something that treats or prevents or alleviates the symptoms of disease."

The answer should be {"sense_index": 2}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cancer
Target surface form: cancer
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for <t>cancer</t>) before advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=cancer%1:26:00:: | definition=any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream | synonyms=malignant neoplastic disease
2. sense_key=cancer%1:18:00:: | definition=(astrology) a person who is born while the sun is in Cancer | synonyms=Crab
3. sense_key=cancer%1:17:00:: | definition=a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
4. sense_key=cancer%1:15:00:: | definition=the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 | synonyms=Cancer the Crab, Crab
5. sense_key=cancer%1:05:00:: | definition=type genus of the family Cancridae | synonyms=genus Cancer

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The target word "cancer" appears in a medical/pharmaceutical context describing treatments for malignant tumors. The passage discusses "medicines for cancer," "anticancer medicine," "malignant" growth, and "unresectable" tumors. This clearly refers to sense 1, which defines cancer as "any malignant growth or tumor caused by abnormal and uncontrolled cell division," which matches the medical disease context perfectly. The other senses (zodiacal constellation, astrological sign, crab genus) are completely incompatible with this medical context.

reasoning_content:
The target word is "cancer" in the context of medical/pharmaceutical information about Alimta, a cancer treatment drug.

Let me analyze the context:
- The sentence is: "medicines for cancer"
- This is clearly about disease, specifically malignant tumors
- The broader context is about treating cancer with chemotherapy and anticancer medicines

Now let me look at the candidate senses:

1. sense_key=cancer%1:26:00:: - "any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream" - This is the medical/disease definition. Synonyms: malignant neoplastic disease

2. sense_key=cancer%1:18:00:: - "(astrology) a person who is born while the sun is in Cancer" - This is about astrological signs for people

3. sense_key=cancer%1:17:00:: - "a small zodiacal constellation in the northern hemisphere; between Leo and Gemini" - This is about the constellation

4. sense_key=cancer%1:15:00:: - "the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22" - This is about the zodiac sign

5. sense_key=cancer%1:05:00:: - "type genus of the family Cancridae" - This is about the genus of crabs

In this medical context about treating cancer with anticancer medicines and chemotherapy, the only sense that makes sense is sense 1 - the medical definition of cancer as a malignant growth or tumor.

The answer should be: {"sense_index": 1}


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: advanced
Target surface form: advanced
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before <t>advanced</t> or metastatic non-small cell lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=advanced%5:00:00:precocious:00 | definition=farther along in physical or mental development | examples=the child's skeletal age was classified as `advanced'; children in the advanced classes in elementary school read far above grade average
2. sense_key=advanced%5:00:00:late:02 | definition=comparatively late in a course of development | examples=the illness had reached an advanced stage; an advanced state of exhaustion
3. sense_key=advanced%5:00:00:progressive:01 | definition=ahead of the times | synonyms=forward-looking, innovative, modern | examples=the advanced teaching methods; had advanced views on the subject
4. sense_key=advanced%5:00:02:high:02 | definition=at a higher level in training or knowledge or skill | examples=an advanced degree; an advanced text in physics
5. sense_key=advanced%5:00:00:high-tech:00 | definition=ahead in development; complex or intricate | synonyms=sophisticated | examples=advanced technology; a sophisticated electronic control system
6. sense_key=advanced%5:00:00:late:00 | definition=far along in time | synonyms=ripe | examples=a man of advanced age; advanced in years
7. sense_key=advanced%5:00:00:civilized:00 | definition=(of societies) highly developed especially in technology or industry | examples=advanced societies; an advanced country technologically
8. sense_key=advanced%5:00:00:front:00 | definition=situated ahead or going before | synonyms=advance, in advance | examples=an advance party; at that time the most advanced outpost was still east of the Rockies

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

The word "advanced" in this context describes cancer that is "comparatively late in a course of development." The phrase "advanced or metastatic non-small cell lung cancer" indicates a cancer in a later stage of progression. This directly matches sense 2, which includes the exemplar "the illness had reached an advanced stage," making it semantically identical to the medical context describing the progression of the disease.

reasoning_content:
Let me analyze the context and the candidate senses for the word "advanced" in this medical document about Alimta.

The context is: "advanced or metastatic non-small cell lung cancer that is not affecting the squamous cells"

This is describing a stage of cancer - specifically discussing cancer that is at a later stage of development/progression.

Let me look at each sense:

1. "farther along in physical or mental development" - This refers to development/maturity of a child or person, not applicable here
2. "comparatively late in a course of development" - This is about something being in a later stage of development/progression. The example "the illness had reached an advanced stage" is directly relevant!
3. "ahead of the times" - This is about being innovative or modern, not relevant to cancer description
4. "at a higher level in training or knowledge or skill" - This is about education/training level, not relevant
5. "ahead in development; complex or intricate" - This is about technological advancement or complexity, not relevant
6. "far along in time" - This is about age or time passed, not directly about disease progression
7. "highly developed especially in technology or industry" - This is about societal/technological development, not relevant
8. "situated ahead or going before" - This is about physical position, not relevant

The key phrase is "advanced or metastatic non-small cell lung cancer" - this is describing a cancer that has progressed to a later stage. The cancer is advanced in its progression/development.

Sense 2 seems most appropriate: "comparatively late in a course of development" with the example "the illness had reached an advanced stage" - this is nearly identical to our context.

The answer should be sense index 2.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cell
Context:
What is Alimta? Alimta is a powder that is made up into a solution for infusion (drip into a vein). It contains the active substance pemetrexed. What is Alimta used for? Alimta is used to treat two types of cancer: pleural mesothelioma (cancer of the lining of the lungs that is usually caused by exposure to asbestos). Alimta is used together with cisplatin (another anticancer medicine) when the cancer is unresectable (cannot be removed by surgery alone) and malignant (has spread, or is likely to spread easily, to other parts of the body), in patients who have not received chemotherapy (medicines for cancer) before advanced or metastatic non-small <t>cell</t> lung cancer that is not affecting the squamous cells. Alimta is used in combination with cisplatin in patients who have not been treated before, and on its own in patients who have received another type of chemotherapy in the past.

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

The context discusses "non-small cell lung cancer," which is a medical classification referring to cancer cells that are not small cell carcinoma. In this medical/biological context, "cell" refers to the basic structural and functional unit of living organisms - the fundamental biological unit. This clearly corresponds to sense 2 rather than any other option (compartments, electrical devices, mobile phones, etc.).

reasoning_content:
The target word is "cell" in the context of medical/pharmaceutical text discussing Alimta cancer treatment. The phrase is "non-small cell lung cancer".

Let me analyze the candidate senses:

1. sense_key=cell%1:06:03:: - "any small compartment" (like in honeycomb) - This is about physical compartments
2. sense_key=cell%1:03:00:: - "(biology) the basic structural and functional unit of all organisms" - This is about biological cells, the basic unit of life
3. sense_key=cell%1:06:00:: - "a device that delivers an electric current" - This is about electrical cells
4. sense_key=cell%1:14:00:: - "a small unit serving as part of or as the nucleus of a larger political movement" - This is about organizational cells
5. sense_key=cell%1:06:04:: - "a hand-held mobile radiotelephone" - This is about mobile phones
6. sense_key=cell%1:06:02:: - "small room in which a monk or nun lives" - This is about monastic cells
7. sense_key=cell%1:06:01:: - "a room where a prisoner is kept" - This is about prison cells

In the medical context of "non-small cell lung cancer," the text is referring to a type of lung cancer based on the size/type of cancer cells. "Non-small cell" refers to lung cancer cells that are not small cell carcinoma. This is clearly referring to biological cells - the basic structural and functional units of organisms.

The answer is sense 2: cell%1:03:00:: which is "the basic structural and functional unit of all organisms"