[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: patient
Target surface form: patients
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in <t>patients</t> with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The target word "patients" in this medical context refers to people receiving medical treatment for a condition. The passage discusses dosing, medications, and contraindications specifically for individuals undergoing treatment with Alimta. This matches sense 1 (a person who requires medical care), not the linguistic semantic role described in sense 2.

reasoning_content:
Let me analyze the context of the word "patients" in this medical text.

The context discusses:
- Recommended dose of Alimta
- It's given to patients intravenously
- Patients should take corticosteroid and folic acid
- Patients whose blood counts are abnormal
- Patients with moderate or severe kidney problems

This is clearly about people receiving medical treatment/care.

Let me look at the two candidate senses:

1. sense_key=patient%1:18:00:: | definition=a person who requires medical care | examples=the number of emergency patients has grown rapidly
   - This is the straightforward definition of a patient in the medical context
   - A person who requires medical care
   - The examples match perfectly (emergency patients)

2. sense_key=patient%1:10:00:: | definition=the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause | synonyms=affected role, patient role
   - This is a linguistic/grammatical sense
   - It refers to the semantic role in a sentence (like in linguistics)
   - "affected role" suggests this is about grammar/linguistics

In this medical text, "patients" refers to people who receive medical treatment - literal patients in a healthcare context, not the linguistic semantic role.

The word "patients" appears multiple times:
- "patients should take a corticosteroid" - people receiving treatment
- "in patients whose blood counts are abnormal" - people being treated
- "in patients with moderate or severe kidney problems" - people needing treatment

This is clearly sense 1: a person who requires medical care.


attempt_kind: initial

status: success

[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: moderate
Target surface form: moderate
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with <t>moderate</t> or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=moderate%3:00:00:: | definition=being within reasonable or average limits; not excessive or extreme | examples=moderate prices; a moderate income
2. sense_key=moderate%5:00:00:mild:00 | definition=not extreme | synonyms=temperate | examples=a moderate penalty; temperate in his response to criticism
3. sense_key=moderate%5:00:00:temperate:00 | definition=marked by avoidance of extravagance or extremes | synonyms=restrained | examples=moderate in his demands; restrained in his response

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The context describes "moderate...kidney problems" as a level of severity in a clinical classification. The word "moderate" here indicates a degree that is within a reasonable range—not excessive or extreme—positioned between mild and severe. This matches sense 1's definition of "being within reasonable or average limits; not excessive or extreme."

finish_reason: stop

role: assistant

reasoning_content:
Let me analyze the context for the word "moderate" in the medical text about Alimta.

The sentence is: "Alimta is not recommended for use in patients with moderate or severe kidney problems."

In this context, "moderate" is describing the degree or severity of kidney problems. It's being used to indicate a level of severity that falls between mild and severe.

Let me examine the three candidate senses:

1. sense_key=moderate%3:00:00:: | definition=being within reasonable or average limits; not excessive or extreme | examples=moderate prices; a moderate income
   - This is describing something as being within reasonable/average limits
   - The examples (prices, income) are about quantity or degree in neutral contexts

2. sense_key=moderate%5:00:00:mild:00 | definition=not extreme | synonyms=temperate | examples=a moderate penalty; temperate in his response to criticism
   - This defines it as "not extreme"
   - Examples show it being used to describe penalties and responses
   - This fits the idea of severity level

3. sense_key=moderate%5:00:00:temperate:00 | definition=marked by avoidance of extravagance or extremes | synonyms=restrained | examples=moderate in his demands; restrained in his response
   - This describes it as avoiding extravagance or extremes
   - Examples are about personal behavior/demands
   - This is more about personal restraint

In the medical context, "moderate kidney problems" means kidney problems that are of middle severity - not mild, but not severe. This is clearly about a degree or level of severity on a scale.

Sense 1 uses the adjective attributively to describe something being within reasonable limits - this applies here. "Moderate kidney problems" means kidney problems that are within a moderate range of severity.
Sense 2 emphasizes "not extreme" with examples tied to penalties and responses, while sense 3 centers on personal restraint. The first sense best captures the usage here—it directly defines moderate as within reasonable limits and not excessive, which perfectly describes kidney problems positioned between mild and severe on a severity spectrum.

type: thinking

currency: USD


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: severe
Target surface form: severe
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or <t>severe</t> kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=severe%5:00:00:intense:00 | definition=intensely or extremely bad or unpleasant in degree or quality | synonyms=terrible, wicked | examples=severe pain; a severe case of flu
2. sense_key=severe%5:00:00:strong:00 | definition=very strong or vigorous | synonyms=hard, knockout | examples=strong winds; a hard left to the chin
3. sense_key=severe%5:00:00:plain:01 | definition=severely simple | synonyms=austere, stark, stern | examples=a stark interior
4. sense_key=severe%5:00:02:nonindulgent:00 | definition=unsparing and uncompromising in discipline or judgment; - H.G.Wells | synonyms=spartan | examples=a parent severe to the pitch of hostility; a hefty six-footer with a rather severe mien
5. sense_key=severe%5:00:00:critical:03 | definition=causing fear or anxiety by threatening great harm | synonyms=dangerous, grave, grievous, serious, life-threatening | examples=a dangerous operation; a grave situation
6. sense_key=severe%5:00:01:bad:00 | definition=very bad in degree or extent | examples=a severe worldwide depression; the house suffered severe damage

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 5}
```

The word "severe" in this medical context describes kidney problems that are serious and pose significant health risks. This aligns with sense 5, which defines severe as "causing fear or anxiety by threatening great harm" with synonyms including "grave," "serious," and "dangerous." The context emphasizes that Alimta is not recommended for patients with severe kidney problems because of the threat to health, which matches this sense perfectly.

reasoning_content:
Let me analyze the context to determine which sense of "severe" is being used.

The context is about medical recommendations for using Alimta, a medication. The relevant sentence is: "Alimta is not recommended for use in patients with moderate or severe kidney problems."

In this medical context, "severe" is being used to describe the degree or extent of kidney problems. This is talking about how serious or bad the kidney problems are - specifically that they are at a serious/grave level.

Let me go through the senses:

1. "intensely or extremely bad or unpleasant in degree or quality" - This could work, as severe kidney problems would be extremely bad.

2. "very strong or vigorous" - This doesn't fit well. We're not talking about the strength of kidney problems in a physical sense.

3. "severely simple" (austere, stark, stern) - This doesn't apply to kidney problems.

4. "unsparing and uncompromising in discipline or judgment" - This doesn't apply to medical severity.

5. "causing fear or anxiety by threatening great harm" (dangerous, grave, serious, life-threatening) - This fits well. Severe kidney problems would be serious/grave and could threaten great harm.

6. "very bad in degree or extent" - This also fits well, as severe kidney problems would be very bad in extent/degree.

Comparing senses 1, 5, and 6:
- Sense 1 focuses on "intensely or extremely bad or unpleasant"
- Sense 5 emphasizes the threatening/dangerous aspect and includes synonyms like "dangerous, grave, serious, life-threatening"
- Sense 6 is more about "very bad in degree or extent"

In the medical context, "severe kidney problems" refers to kidney problems that are serious/dangerous/grave - indicating a level of severity that could have significant health consequences. This aligns best with sense 5, which includes the synonyms "dangerous, grave, serious" and the definition about threatening great harm.
Sense 6 is broader and more general, but sense 5 better captures the specific medical meaning here. The inclusion of "grave" and "serious" as synonyms, along with the emphasis on threatening harm, makes sense 5 the most precise fit for how "severe" is used in this clinical context.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: problem
Target surface form: problems
Context:
The recommended dose of Alimta is 500 mg per square metre of body surface area (calculated using the patient s height and weight). It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney <t>problems</t>. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Candidate senses:
1. sense_key=problem%1:26:00:: | definition=a state of difficulty that needs to be resolved | synonyms=job | examples=she and her husband are having problems; it is always a job to contact him
2. sense_key=problem%1:10:00:: | definition=a question raised for consideration or solution | examples=our homework consisted of ten problems to solve
3. sense_key=problem%1:09:00:: | definition=a source of difficulty | synonyms=trouble | examples=one trouble after another delayed the job; what's the problem?

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 3}
```

The word "problems" in this medical context refers to kidney conditions or disorders that are sources of difficulty. Sense 3 ("a source of difficulty" with synonym "trouble") best captures this usage, as "kidney problems" denotes medical conditions causing dysfunction or complications. Sense 2 is clearly inapplicable (mathematical/logical problems), and while sense 1 could work, sense 3 is more precise with its "source of difficulty" definition and "trouble" synonym, which naturally aligns with medical pathology.

reasoning_content:
Let me analyze the context where "problems" is used:

"Alimta is not recommended for use in patients with moderate or severe kidney problems."

The word "problems" here refers to medical conditions or difficulties related to kidney function. Let me examine each candidate sense:

1. **sense_key=problem%1:26:00::** - "a state of difficulty that needs to be resolved" with synonyms "job" and examples like "she and her husband are having problems; it is always a job to contact him"
   - This refers to difficulties or troubles in a general sense that need resolution
   - This fits the medical context where kidney problems are conditions that need to be addressed

2. **sense_key=problem%1:10:00::** - "a question raised for consideration or solution" with examples like "our homework consisted of ten problems to solve"
   - This is clearly about mathematical or logical problems/questions
   - This doesn't fit the context at all

3. **sense_key=problem%1:09:00::** - "a source of difficulty" with synonyms "trouble" and examples like "one trouble after another delayed the job; what's the problem?"
   - This refers to something that causes difficulty
   - This fits the medical context - kidney problems are sources of difficulty/dysfunction

Comparing senses 1 and 3:
- Sense 1 emphasizes "a state of difficulty that needs to be resolved"
- Sense 3 emphasizes "a source of difficulty" with synonym "trouble"

In the medical context, "kidney problems" refers to kidney conditions/disorders that are sources of difficulty or dysfunction. This is more aligned with sense 3, which uses the synonym "trouble" and defines it as "a source of difficulty." The example "what's the problem?" also fits naturally in a medical context.

Sense 1 seems more about interpersonal or general situational difficulties, while sense 3 is broader and captures the idea of conditions or issues that cause trouble.

I believe sense 3 is the best fit here.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: more
Target surface form: more
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For <t>more</t> information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=more%3:00:01:: | definition=(comparative of `much' used with mass nouns) a quantifier meaning greater in size or amount or extent or degree | synonyms=more than | examples=more land; more support
2. sense_key=more%3:00:02:: | definition=(comparative of `many' used with count nouns) quantifier meaning greater in number | examples=a hall with more seats; we have no more bananas

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The phrase "For more information" uses "more" as a comparative quantifier modifying the mass noun "information." Since information is uncountable (you cannot say "informations"), this follows the pattern of sense 1, which applies to mass nouns, rather than sense 2, which applies to count nouns.

reasoning_content:
The target word is "more" and I need to determine which sense it refers to in the context: "For <t>more</t> information, see the Summary of Product Characteristics (also part of the EPAR)."

Let me analyze the two candidate senses:

1. Sense 1: (comparative of 'much' used with mass nouns) - "a quantifier meaning greater in size or amount or extent or degree" with examples like "more land; more support"

2. Sense 2: (comparative of 'many' used with count nouns) - "quantifier meaning greater in number" with examples like "a hall with more seats; we have no more bananas"

In the phrase "For more information," the word "information" is a mass noun (uncountable). You would say "more information" not "more informations."

Following the distinction:
- Sense 1 is for mass nouns (much → more)
- Sense 2 is for count nouns (many → more)

Since "information" is a mass noun, the correct sense should be Sense 1.

This fits with the definition of sense 1: it's used with mass nouns and indicates a greater amount or degree of something (in this case, information).


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: information
Target surface form: information
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more <t>information</t>, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=information%1:10:00:: | definition=a message received and understood | synonyms=info
2. sense_key=information%1:09:00:: | definition=knowledge acquired through study or experience or instruction
3. sense_key=information%1:10:02:: | definition=formal accusation of a crime
4. sense_key=information%1:14:00:: | definition=a collection of facts from which conclusions may be drawn | synonyms=data | examples=statistical data
5. sense_key=information%1:07:00:: | definition=(communication theory) a numerical measure of the uncertainty of an outcome | synonyms=selective information, entropy | examples=the signal contained thousands of bits of information

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The phrase "For more information" uses "information" in the sense of knowledge or details that can be received and understood. This is the most common use of the word in technical and instructional contexts, where readers are directed to seek additional details or clarification. Sense 1 ("a message received and understood") best captures this idiomatic usage.

reasoning_content:
Let me analyze the context to determine the best sense for "information" in this passage.

The context is: "For more information, see the Summary of Product Characteristics (also part of the EPAR)."

This is a standard phrase asking the reader to consult additional sources for more details about the topic being discussed (Alimta and its treatment protocols).

Let me evaluate each sense:

1. "a message received and understood" - This is a general definition. Information here is being presented as something the reader can access/seek out for further knowledge.

2. "knowledge acquired through study or experience or instruction" - This could fit, as the Summary of Product Characteristics contains knowledge/details.

3. "formal accusation of a crime" - This is clearly not relevant here. There's no legal context.

4. "a collection of facts from which conclusions may be drawn" - This could fit well. The Summary of Product Characteristics contains facts about the drug that readers can use to understand it better.

5. "(communication theory) a numerical measure of the uncertainty of an outcome" - This is a technical/specialized definition that doesn't apply here.

The phrase "For more information" is a very common expression asking readers to look elsewhere for additional details/facts. The most appropriate sense would be either sense 1 (a message received and understood) or sense 4 (a collection of facts).

Sense 1 is more general and fits the idiomatic usage of "for more information" - it refers to knowledge/details as a message or communication.

Sense 4 specifically emphasizes "facts from which conclusions may be drawn," which also fits well since the Summary of Product Characteristics contains specific facts about the drug.

Actually, sense 1 seems most appropriate for this common usage - "information" as something you seek to "receive and understand" - it's about knowledge or details communicated.

I'll go with sense 1.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: see
Target surface form: see
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=see%2:39:00:: | definition=perceive by sight or have the power to perceive by sight | examples=You have to be a good observer to see all the details; Can you see the bird in that tree?
2. sense_key=see%2:31:01:: | definition=perceive (an idea or situation) mentally | synonyms=understand, realize, realise | examples=Now I see!; I just can't see your point
3. sense_key=see%2:39:02:: | definition=perceive or be contemporaneous with | synonyms=witness, find | examples=We found Republicans winning the offices; You'll see a lot of cheating in this school
4. sense_key=see%2:36:00:: | definition=imagine; conceive of; see in one's mind | synonyms=visualize, visualise, envision, project, fancy, figure | examples=I can't see him on horseback!; I can see what will happen
5. sense_key=see%2:31:00:: | definition=deem to be | synonyms=consider, reckon, view, regard | examples=She views this quite differently from me; I consider her to be shallow
6. sense_key=see%2:31:02:: | definition=get to know or become aware of, usually accidentally | synonyms=learn, hear, get word, get wind, pick up, find out | examples=I learned that she has two grown-up children; I see that you have been promoted
7. sense_key=see%2:39:03:: | definition=see or watch | synonyms=watch, view, catch, take in | examples=view a show on television; This program will be seen all over the world
8. sense_key=see%2:38:00:: | definition=come together | synonyms=meet, run into, encounter, run across, come across | examples=I'll probably see you at the meeting; How nice to see you again!
9. sense_key=see%2:32:00:: | definition=find out, learn, or determine with certainty, usually by making an inquiry or other effort | synonyms=determine, check, find out, ascertain, watch, learn | examples=I want to see whether she speaks French; See whether it works
10. sense_key=see%2:31:03:: | definition=be careful or certain to do something; make certain of something | synonyms=check, insure, see to it, ensure, control, ascertain | examples=He verified that the valves were closed; See that the curtains are closed
11. sense_key=see%2:41:11:: | definition=go to see for professional or business reasons | examples=You should see a lawyer; We had to see a psychiatrist
12. sense_key=see%2:41:12:: | definition=go to see for a social visit | examples=I went to see my friend Mary the other day
13. sense_key=see%2:41:10:: | definition=go to see a place, as for entertainment | synonyms=visit | examples=We went to see the Eiffel Tower in the morning
14. sense_key=see%2:41:14:: | definition=take charge of or deal with | synonyms=attend, take care, look | examples=Could you see about lunch?; I must attend to this matter
15. sense_key=see%2:35:09:: | definition=receive as a specified guest | examples=the doctor will see you now; The minister doesn't see anybody before noon
16. sense_key=see%2:41:00:: | definition=date regularly; have a steady relationship with | synonyms=go steady, go out, date | examples=Did you know that she is seeing an older man?; He is dating his former wife again!
17. sense_key=see%2:39:05:: | definition=see and understand, have a good eye | examples=The artist must first learn to see
18. sense_key=see%2:31:08:: | definition=deliberate or decide | examples=See whether you can come tomorrow; let's see--which movie should we see tonight?
19. sense_key=see%2:39:11:: | definition=observe as if with an eye | examples=The camera saw the burglary and recorded it
20. sense_key=see%2:39:13:: | definition=observe, check out, and look over carefully or inspect | synonyms=examine | examples=The customs agent examined the baggage; I must see your passport before you can enter the country
21. sense_key=see%2:39:12:: | definition=go or live through | synonyms=experience, go through | examples=We had many trials to go through; he saw action in Viet Nam
22. sense_key=see%2:38:03:: | definition=accompany or escort | synonyms=escort | examples=I'll see you to the door
23. sense_key=see%2:33:00:: | definition=match or meet | examples=I saw the bet of one of my fellow players
24. sense_key=see%2:31:13:: | definition=make sense of; assign a meaning to | synonyms=interpret, construe | examples=What message do you see in this letter?; How do you interpret his behavior?

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 9}
```

The word "see" in "For more information, see the Summary of Product Characteristics" is used as an instruction to consult or refer to a document to find out/learn information. This matches sense 9: "find out, learn, or determine with certainty, usually by making an inquiry or other effort" with examples like "I want to see whether she speaks French; See whether it works." The reader is being directed to the document to determine or learn more information.

reasoning_content:
Let me analyze the context for the word "see":

"For more information, <t>see</t> the Summary of Product Characteristics (also part of the EPAR)."

This is a directive/instruction telling the reader to look at/consult/refer to the Summary of Product Characteristics document.

Let me go through the senses:

1. "perceive by sight" - This is literal vision, not applicable here
2. "perceive (an idea or situation) mentally" - understand, realize - Not quite right
3. "perceive or be contemporaneous with" - witness, find - Not right
4. "imagine; conceive of" - Not right
5. "deem to be" - consider, view, regard - Not right
6. "get to know or become aware of" - learn, hear - Not right
7. "see or watch" - watch, view, catch - Not quite
8. "come together" - meet, encounter - Not right
9. "find out, learn, or determine with certainty" - "I want to see whether she speaks French; See whether it works" - Could be relevant, but not quite
10. "be careful or certain to do something; make certain of something" - "See that the curtains are closed" - This is about ensuring something is done, not quite
11. "go to see for professional or business reasons" - Not about going somewhere physically
12. "go to see for a social visit" - Not about social visits
13. "go to see a place, as for entertainment" - Not about visiting places
14. "take charge of or deal with" - "Could you see about lunch?" - This could be relevant in the sense of attending to something
15. "receive as a specified guest" - Not right
16. "date regularly" - Not right
17. "see and understand, have a good eye" - Not right
18. "deliberate or decide" - "See whether you can come tomorrow" - Could be relevant
19. "observe as if with an eye" - Not right
20. "observe, check out, and look over carefully or inspect" - examine - This could work - examining a document
21. "go or live through" - experience - Not right
22. "accompany or escort" - Not right
23. "match or meet" - Not right
24. "make sense of; assign a meaning to" - interpret, construe - Not right

The most natural reading is sense 20 - "examine" or "inspect" - which fits the instruction to consult and review the referenced document for additional details.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: product
Target surface form: Product
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=product%1:06:01:: | definition=commodities offered for sale | synonyms=merchandise, ware | examples=good business depends on having good merchandise; that store offers a variety of products
2. sense_key=product%1:06:00:: | definition=an artifact that has been created by someone or some process | synonyms=production | examples=they improve their product every year; they export most of their agricultural production
3. sense_key=product%1:09:00:: | definition=a quantity obtained by multiplication | synonyms=mathematical product | examples=the product of 2 and 3 is 6
4. sense_key=product%1:27:00:: | definition=a chemical substance formed as a result of a chemical reaction | examples=a product of lime and nitric acid
5. sense_key=product%1:19:00:: | definition=a consequence of someone's efforts or of a particular set of circumstances | examples=skill is the product of hours of practice; his reaction was the product of hunger and fatigue
6. sense_key=product%1:14:00:: | definition=the set of elements common to two or more sets | synonyms=intersection, Cartesian product | examples=the set of red hats is the intersection of the set of hats and the set of red things

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

The context refers to "Summary of Product Characteristics," which is a standard regulatory document for pharmaceutical products. In this medical context, "Product" refers to Alimta as a manufactured pharmaceutical preparation—an artifact created through a chemical/manufacturing process. This matches sense 2 ("an artifact that has been created by someone or some process") better than the commodity/merchandise sense, as the focus is on the creation and characteristics of the pharmaceutical product itself.

reasoning_content:
Let me analyze the context and find the best sense for "Product" in this sentence:

"For more information, see the Summary of <t>Product</t> Characteristics (also part of the EPAR)."

This is referring to pharmaceutical/medical documentation. The sentence is talking about a "Summary of Product Characteristics," which is a standard medical term used for prescribing information about pharmaceutical products.

Let me examine each sense:

1. sense_key=product%1:06:01:: - "commodities offered for sale" - This is about products for sale/merchandise
2. sense_key=product%1:06:00:: - "an artifact that has been created by someone or some process" - A created artifact/production
3. sense_key=product%1:09:00:: - "a quantity obtained by multiplication" - Mathematical product
4. sense_key=product%1:27:00:: - "a chemical substance formed as a result of a chemical reaction" - Chemical product
5. sense_key=product%1:19:00:: - "a consequence of someone's efforts or of a particular set of circumstances" - A consequence/result
6. sense_key=product%1:14:00:: - "the set of elements common to two or more sets" - Mathematical/set theory

In this medical context, "Product" refers to a pharmaceutical product (Alimta). The "Summary of Product Characteristics" is a standard EU regulatory document for pharmaceuticals.

The best fit would be sense 1 or 2:
- Sense 1 (commodities offered for sale/merchandise) fits because pharmaceutical products are indeed goods/medicines offered for sale
- Sense 2 (artifact created by someone or process) also fits as it's something created through a manufacturing/chemical process

Given that this is specifically a pharmaceutical product (a medicine/drug), and that Alimta is a medication that is manufactured and sold, sense 1 "commodities offered for sale" or sense 2 "an artifact that has been created" would both be reasonable.
Sense 1 emphasizes the commercial aspect while sense 2 highlights the manufacturing process. In pharmaceutical regulatory documents, "product" typically denotes something manufactured and distributed as a medicine. I think sense 2 better captures this manufacturing dimension, which is central to how pharmaceuticals are defined in regulatory contexts.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: part
Target surface form: part
Context:
It is given once every three weeks as an intravenous infusion lasting 10 minutes. To reduce side effects, patients should take a corticosteroid and folic acid (a type of vitamin), and receive injections of vitamin B12 during treatment with Alimta. When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR). How does Alimta work?

Candidate senses:
1. sense_key=part%1:24:00:: | definition=something determined in relation to something that includes it | synonyms=portion, component part, component, constituent | examples=he wanted to feel a part of something bigger than himself; I read a portion of the manuscript
2. sense_key=part%1:06:00:: | definition=something less than the whole of a human artifact | synonyms=portion | examples=the rear part of the house; glue the two parts together
3. sense_key=part%1:17:00:: | definition=a portion of a natural object | synonyms=piece | examples=they analyzed the river into three parts; he needed a piece of granite
4. sense_key=part%1:09:02:: | definition=that which concerns a person with regard to a particular role or situation | examples=it requires vigilance on our part; they resisted every effort on his part
5. sense_key=part%1:15:00:: | definition=the extended spatial location of something | synonyms=region | examples=the farming regions of France; religions in all parts of the world
6. sense_key=part%1:04:01:: | definition=the actions and activities assigned to or required or expected of a person or group | synonyms=function, office, role | examples=the function of a teacher; the government must do its part
7. sense_key=part%1:09:01:: | definition=an actor's portrayal of someone in a play | synonyms=character, role, theatrical role, persona | examples=she played the part of Desdemona
8. sense_key=part%1:21:00:: | definition=assets belonging to or due to or contributed by an individual person or group | synonyms=share, portion, percentage | examples=he wanted his share in cash
9. sense_key=part%1:09:00:: | definition=one of the portions into which something is regarded as divided and which together constitute a whole | synonyms=section, division | examples=the written part of the exam; the finance section of the company
10. sense_key=part%1:08:01:: | definition=a line of scalp that can be seen when sections of hair are combed in opposite directions | synonyms=parting | examples=his part was right in the middle
11. sense_key=part%1:10:00:: | definition=the melody carried by a particular voice or instrument in polyphonic music | synonyms=voice | examples=he tried to sing the tenor part
12. sense_key=part%1:04:03:: | definition=the part played by a person in bringing about a result | synonyms=contribution, share | examples=I am proud of my contribution in advancing the project; they all did their share of the work

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

In this context, "part of the EPAR" refers to the Summary of Product Characteristics being a component or constituent of a larger document (the EPAR). This matches sense 1, which defines "part" as "something determined in relation to something that includes it" with synonyms like "portion," "component," and "constituent." The phrase clearly indicates that the Summary is one component within the broader EPAR document.

reasoning_content:
Let me analyze the context where "part" appears in the sentence:

"For more information, see the Summary of Product Characteristics (also <t>part</t> of the EPAR)."

The word "part" here means that the Summary of Product Characteristics is "a part of" or "a component/portion of" the EPAR (European Public Assessment Report).

Let me examine each sense:

1. sense 1: "something determined in relation to something that includes it" - synonyms: portion, component part, component, constituent. Examples mention "a part of something bigger than himself"
2. sense 2: "something less than the whole of a human artifact" - synonyms: portion. Examples: "the rear part of the house"
3. sense 3: "a portion of a natural object" - synonyms: piece. Examples: "they analyzed the river into three parts"
4. sense 4: "that which concerns a person with regard to a particular role or situation"
5. sense 5: "the extended spatial location of something" - region
6. sense 6: "the actions and activities assigned to or required or expected of a person or group"
7. sense 7: "an actor's portrayal of someone in a play"
8. sense 8: "assets belonging to or due to or contributed by an individual person or group"
9. sense 9: "one of the portions into which something is regarded as divided"
10. sense 10: "a line of scalp that can be seen when sections of hair are combed"
11. sense 11: "the melody carried by a particular voice or instrument"
12. sense 12: "the part played by a person in bringing about a result"

In this context, "part of the EPAR" means the Summary of Product Characteristics is a component/portion of the larger EPAR document.
Sense 1 fits most naturally here—the Summary functions as a constituent element within the larger whole, similar to how the example describes wanting to be "part of something bigger." While sense 9 could apply as a divided portion, sense 1 better captures the relationship of this document as an integral component of the EPAR.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The <t>active</t> substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
7. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
13. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 6}
```

The context refers to "the active substance in Alimta" - meaning the substance that exerts a biological effect and produces a therapeutic change. This matches sense 6: "exerting influence or producing a change or effect," which explicitly includes the example "an active ingredient" - a direct parallel to "active substance" in pharmaceutical contexts.

reasoning_content:
Let me analyze the context where "active" appears:

"The active substance in Alimta, pemetrexed, is a cytotoxic medicine..."

Here, "active substance" refers to the component that has a biological effect - it's the substance that is responsible for the drug's action and produces an effect in the body.

Looking at the candidate senses:

1. sense_key=active%3:00:02:: - tending to become more severe (related to disease progression)
2. sense_key=active%5:00:00:operational:00 - military/naval operations
3. sense_key=active%3:00:03:: - disposed to take action or effectuate change
4. sense_key=active%5:00:00:involved:00 - taking part in an activity
5. sense_key=active%3:00:01:: - characterized by energetic activity
6. sense_key=active%3:00:07:: - **exerting influence or producing a change or effect** - examples include "an active ingredient"
7. sense_key=active%3:00:06:: - full of activity or engaged in continuous activity
8. sense_key=active%5:00:00:existent:00 - in operation
9. sense_key=active%3:00:10:: - (of the sun) characterized by sunspots
10. sense_key=active%3:00:09:: - expressing actor in grammar
11. sense_key=active%3:00:00:: - expressing action rather than state of being
12. sense_key=active%3:00:05:: - (of volcanos) capable of erupting
13. sense_key=active%3:00:04:: - (of volcanos) erupting or liable to erupt
14. sense_key=active%3:00:08:: - engaged in full-time work

Sense 6 (active%3:00:07::) is the correct match. The definition "exerting influence or producing a change or effect" with the example "an active ingredient" directly parallels the pharmaceutical usage where pemetrexed is the active substance—the component responsible for the drug's therapeutic effect.

The answer is sense index 6.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: substance
Target surface form: substance
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=substance%1:03:00:: | definition=the real physical matter of which a person or thing consists | examples=DNA is the substance of our genes
2. sense_key=substance%1:09:01:: | definition=the choicest or most essential or most vital part of some idea or experience | synonyms=kernel, core, center, centre, essence, gist | examples=the gist of the prosecutor's argument; the heart and soul of the Republican Party
3. sense_key=substance%1:09:00:: | definition=the idea that is intended | synonyms=meaning | examples=What is the meaning of this proverb?
4. sense_key=substance%1:27:00:: | definition=material of a particular kind or constitution | examples=the immune response recognizes invading substances
5. sense_key=substance%1:21:00:: | definition=considerable capital (wealth or income) | synonyms=means | examples=he is a man of means
6. sense_key=substance%1:10:00:: | definition=what a communication that is about something is about | synonyms=message, content, subject matter
7. sense_key=substance%1:03:01:: | definition=a particular kind or species of matter with uniform properties | examples=shigella is one of the most toxic substances known to man

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 7}
```

The context refers to pemetrexed as "the active substance in Alimta" - meaning a specific chemical compound with defined properties that functions as the active ingredient in the medication. Sense 7 ("a particular kind or species of matter with uniform properties") best captures this usage, where "substance" denotes a distinct chemical or medicinal compound. The example about "shigella is one of the most toxic substances known to man" parallels the medical/toxicological context of the given sentence.

reasoning_content:
Let me analyze the context where "substance" appears:

"The active <t>substance</t> in Alimta, pemetrexed, is a cytotoxic medicine..."

The sentence is saying that pemetrexed is the active substance/ingredient in Alimta. It's referring to a chemical compound that is the main ingredient in the drug.

Let me evaluate each sense:

1. "the real physical matter of which a person or thing consists" - This is about the physical matter/material composition. While pemetrexed is physical matter, this seems more about the composition of something.

2. "the choicest or most essential or most vital part of some idea or experience" - This is about the essence of an idea/experience, not a physical chemical.

3. "the idea that is intended" - This is about meaning/intention, not applicable here.

4. "material of a particular kind or constitution" - This fits. Pemetrexed is "a particular kind of material" that is a medicine/chemical compound. The example "the immune response recognizes invading substances" shows substances as chemical/biological materials.

5. "considerable capital" - This is about wealth, not applicable.

6. "what a communication is about" - This is about subject matter of communication, not applicable.

7. "a particular kind or species of matter with uniform properties" - This also fits well. Pemetrexed is a particular kind of matter with specific properties (it's a cytotoxic medicine). The example "shigella is one of the most toxic substances known to man" shows a biological substance being referred to this way.

Between 4 and 7, they're quite similar. Both refer to a particular kind of material/matter.

Sense 4: "material of a particular kind or constitution" - uses the example of "invading substances" in immunology
Sense 7 seems more precise here since it specifically emphasizes a particular kind or species of matter, and the medical toxicity example aligns closely with pemetrexed being a cytotoxic compound. I'll go with sense 7.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

The target word "medicine" in this context refers to a pharmaceutical substance (pemetrexed) used to treat disease. This aligns with sense 2, which defines medicine as "something that treats or prevents or alleviates the symptoms of disease" with synonyms including "medication, medicament, medicinal drug." The context explicitly describes it as "a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells)," which clearly indicates a therapeutic substance rather than a field of study (sense 1, 3) or punishment (sense 4).

reasoning_content:
Let me analyze the target word "medicine" in the given context.

The context mentions: "pemetrexed, is a cytotoxic <t>medicine</t> (a medicine that kills cells that are dividing, such as cancer cells)"

This is clearly referring to medicine as a pharmaceutical substance or medication used to treat disease.

Let me examine the candidate senses:

1. sense_key=medicine%1:09:00:: - "the branches of medical science that deal with nonsurgical techniques" - This is about medical science/specialty, not the actual substance. Not a match.

2. sense_key=medicine%1:06:00:: - "(medicine) something that treats or prevents or alleviates the symptoms of disease" with synonyms "medication, medicament, medicinal drug" - This matches perfectly. The context is describing pemetrexed as a cytotoxic medicine (a substance that treats disease/cancer by killing cells), which aligns with "something that treats or prevents or alleviates the symptoms of disease."

3. sense_key=medicine%1:04:00:: - "the learned profession that is mastered by graduate training in a medical school..." - This is about the medical profession, not a substance. Not a match.

4. sense_key=medicine%1:04:02:: - "punishment for one's actions" - This is clearly not appropriate here.

The best match is sense 2 (index 2), which refers to medicine as a medication or medicinal drug - a substance used to treat disease. The context explicitly uses this sense when it says pemetrexed "is a cytotoxic medicine (a medicine that kills cells...)".


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: medicine
Target surface form: medicine
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=medicine%1:09:00:: | definition=the branches of medical science that deal with nonsurgical techniques | synonyms=medical specialty
2. sense_key=medicine%1:06:00:: | definition=(medicine) something that treats or prevents or alleviates the symptoms of disease | synonyms=medication, medicament, medicinal drug
3. sense_key=medicine%1:04:00:: | definition=the learned profession that is mastered by graduate training in a medical school and that is devoted to preventing or alleviating or curing diseases and injuries | synonyms=practice of medicine | examples=he studied medicine at Harvard
4. sense_key=medicine%1:04:02:: | definition=punishment for one's actions | synonyms=music | examples=you have to face the music; take your medicine

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

The target word "medicine" refers to pemetrexed, a substance used to treat cancer by killing dividing cells. This matches sense 2, which defines medicine as "something that treats or prevents or alleviates the symptoms of disease" with synonyms including "medication" and "medicinal drug." The context explicitly describes it as a cytotoxic substance with a therapeutic function, which aligns perfectly with this sense.

reasoning_content:
Let me analyze the context where "medicine" appears.

The context is about Alimta, a cancer drug. The relevant sentence is:
"The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a <t>medicine</t> that kills cells that are dividing, such as cancer cells)..."

Here, "medicine" is being used to refer to a substance that treats or prevents disease symptoms. It's specifically referring to pemetrexed, which is a drug/medication used to treat cancer.

Let me evaluate the candidate senses:

1. sense_key=medicine%1:09:00:: - "the branches of medical science that deal with nonsurgical techniques" - This refers to fields/branches of medical science, not a substance. Not applicable.

2. sense_key=medicine%1:06:00:: - "(medicine) something that treats or prevents or alleviates the symptoms of disease" with synonyms "medication, medicament, medicinal drug" - This fits perfectly. A medicine is a substance used to treat disease, which is exactly what pemetrexed is in this context.

3. sense_key=medicine%1:04:00:: - "the learned profession that is mastered by graduate training in a medical school..." - This refers to the profession of medicine, not a medicinal substance. Not applicable.

4. sense_key=medicine%1:04:02:: - "punishment for one's actions" - This is a metaphorical/idiomatic meaning (like "take your medicine" meaning accept punishment). Not applicable here.

The best fit is clearly sense 2: medicine as a substance that treats or prevents disease symptoms - i.e., a medication or drug.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: kill
Target surface form: kills
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that <t>kills</t> cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=kill%2:35:00:: | definition=cause to die; put to death, usually intentionally or knowingly | examples=This man killed several people when he tried to rob a bank; The farmer killed a pig for the holidays
2. sense_key=kill%2:41:01:: | definition=thwart the passage of | synonyms=shoot down, defeat, vote down, vote out | examples=kill a motion; he shot down the student's proposal
3. sense_key=kill%2:30:08:: | definition=end or extinguish by forceful means | synonyms=stamp out | examples=Stamp out poverty!
4. sense_key=kill%2:42:00:: | definition=be fatal | examples=cigarettes kill; drunken driving kills
5. sense_key=kill%2:39:00:: | definition=be the source of great pain for | examples=These new shoes are killing me!
6. sense_key=kill%2:37:00:: | definition=overwhelm with hilarity, pleasure, or admiration | examples=The comedian was so funny, he was killing me!
7. sense_key=kill%2:35:06:: | definition=hit with so much force as to make a return impossible, in racket games | examples=She killed the ball
8. sense_key=kill%2:35:05:: | definition=hit with great force | examples=He killed the ball
9. sense_key=kill%2:35:02:: | definition=deprive of life | examples=AIDS has killed thousands in Africa
10. sense_key=kill%2:35:01:: | definition=cause the death of, without intention | examples=She was killed in the collision of three cars
11. sense_key=kill%2:34:00:: | definition=drink down entirely | synonyms=toss off, pop, bolt down, belt down, pour down, down | examples=He downed three martinis before dinner; She killed a bottle of brandy that night
12. sense_key=kill%2:30:00:: | definition=mark for deletion, rub off, or erase | synonyms=obliterate, wipe out | examples=kill these lines in the President's speech
13. sense_key=kill%2:30:04:: | definition=tire out completely | examples=The daily stress of her work is killing her
14. sense_key=kill%2:30:03:: | definition=cause to cease operating | examples=kill the engine
15. sense_key=kill%2:30:02:: | definition=destroy a vitally essential quality of or in | examples=Eating artichokes kills the taste of all other foods

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 9}
```

The context describes pemetrexed as a cytotoxic medicine that "kills cells that are dividing, such as cancer cells." This is describing the biological deprivation of life from cells. Sense 9, "deprive of life," with its example "AIDS has killed thousands in Africa," best matches this medical/biological context where an agent causes the death of organisms or cells.

reasoning_content:
Let me analyze the context for the word "kills" in this sentence:

"The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells)"

The context is about a medicine that destroys/causes the death of cancer cells. The phrase "cytotoxic medicine" means it's toxic to cells - it causes them to die.

Looking at the candidate senses:

1. "cause to die; put to death, usually intentionally or knowingly" - This is the general sense of killing, but "intentionally or knowingly" doesn't fit well here.

2. "thwart the passage of" - Not relevant; this is about blocking a motion.

3. "end or extinguish by forceful means" - Could work, but it's more about stamping out something like poverty.

4. "be fatal" - This could work - "cigarettes kill; drunken driving kills" suggests this is about being fatal/lethal.

5. "be the source of great pain" - Not relevant.

6. "overwhelm with hilarity" - Not relevant.

7-8. Racket games - Not relevant.

9. "deprive of life" - This seems very relevant. "AIDS has killed thousands in Africa" is about causing death.

10. "cause the death of, without intention" - This is specifically about unintentional death.

11. "drink down entirely" - Not relevant.

12. "mark for deletion" - Not relevant.

13. "tire out completely" - Not relevant.

14. "cause to cease operating" - Not relevant.

15. "destroy a vitally essential quality" - Not relevant.

The best fits are sense 9 ("deprive of life") or sense 1 (general killing). Given that we're talking about a cytotoxic medicine that kills cancer cells, and this is about biological/medical context where the medicine causes death to the cells, sense 9 "deprive of life" seems most appropriate.

Sense 9 aligns with the medical/biological context shown in the example "AIDS has killed thousands in Africa," where both involve something depriving organisms of life at a cellular level. While sense 1 captures the core meaning of causing death, sense 9 better fits this specific biological context.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: cell
Target surface form: cells
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills <t>cells</t> that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=cell%1:06:03:: | definition=any small compartment | examples=the cells of a honeycomb
2. sense_key=cell%1:03:00:: | definition=(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
3. sense_key=cell%1:06:00:: | definition=a device that delivers an electric current as the result of a chemical reaction | synonyms=electric cell
4. sense_key=cell%1:14:00:: | definition=a small unit serving as part of or as the nucleus of a larger political movement | synonyms=cadre
5. sense_key=cell%1:06:04:: | definition=a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver | synonyms=cellular telephone, cellular phone, cellphone, mobile phone
6. sense_key=cell%1:06:02:: | definition=small room in which a monk or nun lives | synonyms=cubicle
7. sense_key=cell%1:06:01:: | definition=a room where a prisoner is kept | synonyms=jail cell, prison cell

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 2}
```

The context clearly indicates biological cells. The passage describes pemetrexed as "a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells)" and refers to "nucleotides (the building blocks of DNA and RNA, the genetic material of cells)." This is explicitly discussing cells as the basic structural and functional units of organisms, which is sense 2.

reasoning_content:
Let me analyze the context to determine the correct sense of "cells" in this medical/pharmaceutical passage.

The passage is discussing Alimta (pemetrexed), which is described as "a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells)". This is clearly referring to biological cells - the basic structural and functional units of organisms that divide and grow.

The context shows:
1. "a medicine that kills cells that are dividing" - this is specifically referring to cells in the biological sense
2. "such as cancer cells" - further clarifies this is biological cells
3. The passage mentions "nucleotides (the building blocks of DNA and RNA, the genetic material of cells)" - again referring to biological cells

Looking at the candidate senses:
1. "any small compartment" - too general, refers to physical compartments like honeycomb
2. "(biology) the basic structural and functional unit of all organisms" - THIS IS THE CORRECT ONE. This matches the context perfectly - we're talking about biological cells that divide, have cancer variants, and contain genetic material (DNA and RNA)
3. "a device that delivers electric current" - not relevant to this context
4. "a small unit serving as part of a larger political movement" - not relevant
5. "a hand-held mobile radiotelephone" - not relevant (informal usage of "cell" but not the intended meaning here)
6. "small room in which a monk or nun lives" - not relevant
7. "a room where a prisoner is kept" - not relevant

The answer is clearly sense 2, which is the biological definition.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: divide
Target surface form: dividing
Context:
When Alimta is given with cisplatin, an anti-emetic medicine (to prevent vomiting) and fluids (to prevent dehydration) should also be given before or after the cisplatin dose. Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are <t>dividing</t>, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells).

Candidate senses:
1. sense_key=divide%2:41:00:: | definition=separate into parts or portions | synonyms=split, split up, separate, dissever, carve up | examples=divide the cake into three equal parts; The British carved up the Ottoman Empire after World War I
2. sense_key=divide%2:31:00:: | definition=perform a division | synonyms=fraction | examples=Can you divide 49 by seven?
3. sense_key=divide%2:42:00:: | definition=act as a barrier between; stand between | synonyms=separate | examples=The mountain range divides the two countries
4. sense_key=divide%2:35:00:: | definition=come apart | synonyms=separate, part | examples=The two pieces that we had glued separated
5. sense_key=divide%2:38:00:: | definition=make a division or separation | synonyms=separate
6. sense_key=divide%2:35:01:: | definition=force, take, or pull apart | synonyms=separate, disunite, part | examples=He separated the fighting children; Moses parted the Red Sea

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
{"sense_index": 6}

The context describes cells that are "dividing" - undergoing the biological process of cell division where cells actively split and separate into daughter cells. Sense 6 ("force, take, or pull apart") best captures this biological meaning, where cells separate during mitosis. The synonyms "separate, disunite, part" align with the process of cell division occurring in cancer cells.

reasoning_content:
Let me analyze the context to determine which sense of "divide" is being used.

The sentence is: "The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells)"

In this context, "dividing" refers to cells that are actively dividing - meaning cells that are undergoing cell division/mitosis, where one cell separates into two cells. The word is describing a biological process where cells are splitting or separating into daughter cells.

Let me consider each sense:

1. "separate into parts or portions" - This is about dividing/splitting something into parts (like dividing a cake). While cell division does involve separation, this sense is more about intentional division into portions.

2. "perform a division" - This is mathematical division (like dividing 49 by 7). Not applicable here.

3. "act as a barrier between" - This is about something standing between two things. Not applicable.

4. "come apart" - This means to separate naturally or accidentally. This could apply to cells coming apart during division.

5. "make a division or separation" - This is about creating a division or separation.

6. "force, take, or pull apart" - This is about forcefully separating something.

The biological context of "cells that are dividing" refers to cells undergoing mitosis/cell division - a process where cells actively separate and split into daughter cells. This is best captured by sense 4 "come apart" or sense 6 "force, take, or pull apart" since cell division involves the actual splitting of cells.

Actually, looking more carefully, "dividing cells" in biology means cells that are in the process of cell division. Sense 4 "come apart" and sense 6 "force, take, or pull apart" both describe this process of separation. Sense 6 seems more precise since cell division involves active pulling apart of cellular components.
However, sense 1 also captures what's happening—a cell separates into two daughter cells. But in biological terminology, sense 6 "force, take, or pull apart" with its synonyms "separate, disunite, part" best describes the active process of cells splitting during mitosis. That's the most fitting sense.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: body
Target surface form: body
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the <t>body</t>, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=body%1:08:00:: | definition=the entire structure of an organism (an animal, plant, or human being) | synonyms=organic structure, physical structure | examples=he felt as if his whole body were on fire
2. sense_key=body%1:14:00:: | definition=a group of persons associated by some common tie or occupation and regarded as an entity | examples=the whole body filed out of the auditorium; the student body
3. sense_key=body%1:08:02:: | definition=a natural object consisting of a dead animal or person | synonyms=dead body | examples=they found the body in the lake
4. sense_key=body%1:17:00:: | definition=an individual 3-dimensional object that has mass and that is distinguishable from other objects | examples=heavenly body
5. sense_key=body%1:08:01:: | definition=the body excluding the head and neck and limbs | synonyms=torso, trunk | examples=they moved their arms and legs and bodies
6. sense_key=body%1:14:02:: | definition=a collection of particulars considered as a system | examples=a body of law; a body of doctrine
7. sense_key=body%1:07:00:: | definition=the property of holding together and retaining its shape | synonyms=consistency, consistence, eubstance | examples=wool has more body than rayon; when the dough has enough consistency it is ready to bake
8. sense_key=body%1:10:00:: | definition=the central message of a communication | examples=the body of the message was short
9. sense_key=body%1:07:01:: | definition=the main mass of a thing
10. sense_key=body%1:06:01:: | definition=a resonating chamber in a musical instrument (as the body of a violin) | synonyms=soundbox
11. sense_key=body%1:06:00:: | definition=the external structure of a vehicle | examples=the body of the car was badly rusted

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 1}
```

The word "body" in this medical context refers to the entire structure of a human organism. The sentence discusses what happens to pemetrexed "in the body" when a person is treated with Alimta, clearly indicating the complete physical organism rather than any other meaning.

reasoning_content:
Let me analyze the context where "body" appears:

"In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells)."

This is clearly referring to a human or animal body in a medical/biological context. The text is discussing what happens to a medicine (pemetrexed) when it's in the body. This is referring to the entire organism or physical structure.

Looking at the candidate senses:
1. "the entire structure of an organism (an animal, plant, or human being)" - This fits perfectly. It's about the entire organism.
2. "a group of persons associated by some common tie" - No, doesn't fit
3. "a natural object consisting of a dead animal or person" - No, this is about a living body
4. "an individual 3-dimensional object that has mass" - Too generic
5. "the body excluding the head and neck and limbs" - No, this refers to the torso/trunk specifically
6. "a collection of particulars considered as a system" - No, this is more abstract
7. "the property of holding together and retaining its shape" - No, this is about consistency
8. "the central message of a communication" - No, not relevant
9. "the main mass of a thing" - Possibly, but less specific
10. "a resonating chamber in a musical instrument" - No, not relevant
11. "the external structure of a vehicle" - No, not relevant

The best fit is sense 1: "the entire structure of an organism (an animal, plant, or human being)" - This is the standard use of "body" in medical/biological contexts referring to the whole organism. The example "he felt as if his whole body were on fire" shows this same type of usage.


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: convert
Target surface form: converted
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is <t>converted</t> into an active form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=convert%2:30:00:: | definition=change from one system to another or to a new plan or policy | synonyms=change over | examples=We converted from 220 to 110 Volt
2. sense_key=convert%2:30:03:: | definition=change the nature, purpose, or function of something | examples=convert lead into gold; convert hotels into jails
3. sense_key=convert%2:30:01:: | definition=change religious beliefs, or adopt a religious belief | examples=She converted to Buddhism
4. sense_key=convert%2:30:02:: | definition=exchange or replace with another, usually of the same kind or category | synonyms=change, exchange, commute | examples=Could you convert my dollars into pounds?; He changed his name
5. sense_key=convert%2:30:07:: | definition=cause to adopt a new or different faith | examples=The missionaries converted the Indian population
6. sense_key=convert%2:33:02:: | definition=score an extra point or points after touchdown by kicking the ball through the uprights or advancing the ball into the end zone | examples=Smith converted and his team won
7. sense_key=convert%2:33:01:: | definition=complete successfully | examples=score a penalty shot or free throw
8. sense_key=convert%2:33:00:: | definition=score (a spare)
9. sense_key=convert%2:32:00:: | definition=make (someone) agree, understand, or realize the truth or validity of something | synonyms=win over, convince | examples=He had finally convinced several customers of the advantages of his product
10. sense_key=convert%2:30:09:: | definition=exchange a penalty for a less severe one | synonyms=commute, exchange
11. sense_key=convert%2:30:04:: | definition=change in nature, purpose, or function; undergo a chemical change | examples=The substance converts to an acid

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 11}
```

The context describes a chemical transformation where pemetrexed undergoes a biological change into an active form. Sense 11 ("change in nature, purpose, or function; undergo a chemical change") is the best fit, as it explicitly addresses chemical changes with the example "The substance converts to an acid," which parallels the biochemical transformation described in the sentence.

reasoning_content:
Let me analyze the context and the senses to find the best fit.

The sentence is: "In the body, pemetrexed is converted into an active form that blocks the activity of the enzymes..."

This is describing a chemical/biological transformation where pemetrexed changes into an active form. This is a chemical process.

Let me look at the candidate senses:

1. "change from one system to another or to a new plan or policy" - Not about chemical transformation
2. "change the nature, purpose, or function of something" - Examples: "convert lead into gold; convert hotels into jails" - This could fit, as it's about changing something into something else
3. "change religious beliefs" - Not applicable
4. "exchange or replace with another" - Could fit, but more about exchanging things
5. "cause to adopt a new or different faith" - Not applicable
6-8. Sports-related senses - Not applicable
9. "make someone agree" - Not applicable
10. "exchange a penalty for a less severe one" - Not applicable
11. "change in nature, purpose, or function; undergo a chemical change" - Examples: "The substance converts to an acid" - This seems perfect for the chemical transformation described

The key phrase is "converted into an active form" - this is clearly a chemical/biological transformation. Sense 11 explicitly mentions "undergo a chemical change" and has an example about substances undergoing conversion.

Sense 2 could also work (change the nature, purpose, or function), but sense 11 is more specific to chemical changes.

The best answer is sense 11 (index 11).


[System] You are an English linguist performing fine-grained Word Sense Disambiguation. WordNet glosses are schematic. Use the sentence context, the examples, and the synonyms to choose the best indexed sense. Do not hedge. Choose the single best indexed sense.

[User]
Target lemma: active
Target surface form: active
Context:
Treatment should be delayed or discontinued, or the dose reduced, in patients whose blood counts are abnormal or who have certain other side effects. Alimta is not recommended for use in patients with moderate or severe kidney problems. For more information, see the Summary of Product Characteristics (also part of the EPAR). How does Alimta work? The active substance in Alimta, pemetrexed, is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells), which belongs to the group antimetabolites. In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides (the building blocks of DNA and RNA, the genetic material of cells). How has Alimta been studied?

Candidate senses:
1. sense_key=active%3:00:02:: | definition=tending to become more severe or wider in scope | examples=active tuberculosis
2. sense_key=active%5:00:00:operational:00 | definition=engaged in or ready for military or naval operations | synonyms=combat-ready, fighting | examples=on active duty; the platoon is combat-ready
3. sense_key=active%3:00:03:: | definition=disposed to take action or effectuate change | examples=a director who takes an active interest in corporate operations; an active antagonism
4. sense_key=active%5:00:00:involved:00 | definition=taking part in an activity | synonyms=participating | examples=an active member of the club; he was politically active
5. sense_key=active%3:00:01:: | definition=characterized by energetic activity | examples=an active toddler; active as a gazelle
6. sense_key=active%3:00:07:: | definition=exerting influence or producing a change or effect | examples=an active ingredient
7. sense_key=active%3:00:06:: | definition=full of activity or engaged in continuous activity | examples=an active seaport; an active bond market
8. sense_key=active%5:00:00:existent:00 | definition=in operation | synonyms=alive | examples=keep hope alive; the tradition was still alive
9. sense_key=active%3:00:10:: | definition=(of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. sense_key=active%3:00:09:: | definition=expressing that the subject of the sentence has the semantic function of actor: | examples=Hemingway favors active constructions
11. sense_key=active%3:00:00:: | definition=(used of verbs (e.g. `to run') and participial adjectives (e.g. `running' in `running water')) expressing action rather than a state of being | synonyms=dynamic
12. sense_key=active%3:00:05:: | definition=(of e.g. volcanos) capable of erupting
13. sense_key=active%3:00:04:: | definition=(of e.g. volcanos) erupting or liable to erupt | examples=active volcanos
14. sense_key=active%3:00:08:: | definition=engaged in full-time work | examples=active duty; though past retirement age he is still active in his profession

Instructions:
1. Choose the single best indexed sense for the target word in context.
2. WordNet glosses are schematic; use the context, synonyms, and examples together.
3. Do not answer with a WordNet sense key.
4. Return only a JSON object exactly like {"sense_index": 3}.

raw_output:
```json
{"sense_index": 6}
```

The word "active" here describes a form of pemetrexed that is capable of producing a biological effect—specifically, blocking enzyme activity. This matches sense 6 ("exerting influence or producing a change or effect"), which is strongly supported by the parallel example "an active ingredient" used in pharmaceutical contexts to denote a substance capable of producing therapeutic effects.

reasoning_content:
Let me analyze the context carefully. The sentence is:

"In the body, pemetrexed is converted into an <t>active</t> form that blocks the activity of the enzymes that are involved in producing nucleotides..."

The word "active" here is describing a form/state of the drug pemetrexed that is capable of blocking enzyme activity. The drug is being converted into a form that "exerts an influence" or "produces a change or effect" - i.e., it becomes chemically/biologically functional and can act on enzymes.

Let me go through the candidate senses:

1. "tending to become more severe" - No, not about disease severity
2. "military/naval operations" - No, not relevant
3. "disposed to take action" - This could work, but it's typically used for people/entities
4. "taking part in activity" - Not the right meaning
5. "energetic activity" - Not right, not about personal energy
6. "exerting influence or producing a change or effect" - YES! This is describing something that produces an effect. An "active form" of a drug is a form that exerts a biological effect/influence
7. "full of activity" - Not quite right
8. "in operation" - This could work, but sense 6 is more precise
9. "sun sunspots" - Not relevant
10. "verb expressing action" - Not relevant
11. "verbs/participles expressing action" - Not relevant
12. "volcanoes capable of erupting" - Not relevant
13. "volcanoes erupting" - Not relevant
14. "full-time work" - Not relevant

The best fit is sense 6: "exerting influence or producing a change or effect | examples=an active ingredient"

This is particularly clear because the example "an active ingredient" is almost exactly parallel to "active form" in the medical/pharmaceutical context. Both refer to a form that is capable of producing an effect.